CN102133273A - Traditional Chinese medicine lipid-lowing and aperient capsule and preparation method thereof - Google Patents
Traditional Chinese medicine lipid-lowing and aperient capsule and preparation method thereof Download PDFInfo
- Publication number
- CN102133273A CN102133273A CN201110041148.6A CN201110041148A CN102133273A CN 102133273 A CN102133273 A CN 102133273A CN 201110041148 A CN201110041148 A CN 201110041148A CN 102133273 A CN102133273 A CN 102133273A
- Authority
- CN
- China
- Prior art keywords
- radix
- parts
- chinese medicine
- fine powder
- capsule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a novel traditional Chinese medicine lipid-lowing and aperient capsule and a preparation method thereof, and belongs to the field of traditional Chinese medicines. Rhubarb, weathered sodium sulfate, ginseng, lucid ganoderma, cinnamon and liquoric root are taken as raw materials, and are combined according to different pharmacological properties and physicochemical properties of active ingredients of the traditional Chinese medicines in a certain ratio to be prepared into a clinical medicinal formulation. The Chinese medicinal composition is clinically used for diseases such as hyperlipidemia, constipation, abdominal distention and anorexia, obesity and the like caused by gastrointestinal excess heat and spleen-Qi deficiency, the total effective rate for treating the hyperlipemia is 97.8 percent, and the total recovery rate and the effective rate for treating habitual constipation are 100 percent.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, belong to the field of Chinese medicines, be specifically related to a kind of Chinese medicine blood fat reducing relieving constipation capsule and preparation method thereof.
Background technology
Constipation is a kind of commonly encountered diseases, not a kind of disease of especially severe outwardly, but in fact except bring huge misery and worry to the patient, had a strong impact on outside quality of life, also can not in time discharge because of the refuse in the intestinal, cause a large amount of noxious substances in intestinal, to accumulate for a long time, thereby bring out a series of other diseases.In addition, for hepatopath, hyperpietic, because constipation Overexertion when making defecation, serious life-threatening burst accident such as bring out that arteries breaks easily.So constipation is an immeasurable serious disease.The medicine that is used for the treatment of at present constipation clinically has osmotic laxative, irritant laxative, emollient laxative, permeability caccagogue etc., though certain effect is all arranged, mostly is and cures the symptoms, not the disease, even cause some side effect.So still need the more safe and effective relieving constipation medicine of research and development.
Hyperlipidemia also is a kind of very harmful commonly encountered diseases, is the main cause of bringing out cardio cerebrovascular affection, the sickness rate height.The medicine ubiquity that uses clinically is than big toxic and side effects at present.
Chinese medicine is the national treasure of China, has accumulated the experience of many treatment constipation in secular medical practice, has obtained effect preferably.On theory of Chinese medical science, the constipation majority is owing to gastrointestinal excess-heat, temper are lost due to the void, adopts the Chinese medicine composition of the QI invigorating of reducing phlegm and internal heat to nurse one's health, and can fundamentally treat constipation, the achievement that the present invention obtains from this exploration just.
Summary of the invention
The object of the invention is to provide a kind of can fundamentally treat hyperlipidemia, constipation, and the Chinese medicine composition that has no side effect; Another purpose is to provide its preparation method.
Be to realize the object of the invention, it is that preparation of raw material forms that the present invention selects following Chinese medicine component for use, and each component is in weight portion:
Radix Et Rhizoma Rhei 32---50 parts of 320 parts of Matrii Sulfas Exsiccatus 8---80 parts of Radix Ginsengs 5---
Ganoderma 1---75 parts of 10 portions of Cortex Cinnamomis 2.5---25 portions of Radix Glycyrrhizaes 7.5---.
Above component is preferred:
15 parts in 5 portions of Radix Glycyrrhizaes of 2 portions of Cortex Cinnamomis of 10 portions of Ganodermas of 16 parts of Radix Ginsengs of 64 parts of Matrii Sulfas Exsiccatus of Radix Et Rhizoma Rhei.
In the Chinese medicine composition of the present invention, per 0.5 gram contains Radix Et Rhizoma Rhei with emodin (C
15H
10O
5) and chrysophanol (C
15H
10O
4) the total amount meter, must not be less than 2.70 milligrams.Per 0.5 gram contains Radix Ginseng with the ginsenoside Rg in the described Chinese medicine composition
1Be no less than 0.17 milligram with ginsenoside Re's total amount meter.Per 0.5 gram glycyrrhizic acid content is no less than 6.0 milligrams in the described Chinese medicine composition.Radix Et Rhizoma Rhei, ginsenoside Rg
1With the assay method of ginsenoside Re, glycyrrhizic acid be high-efficient liquid phase technique.
Chinese medicine composition of the present invention prepares by following method:
Get the formula ratio Radix Glycyrrhizae, clean remove impurity, be ground into fine powder, add its 6-10 times of water gagings, supersound extraction, filter cleaner, the filtrate decompression vacuum concentration gets thick paste, drying is pulverized, sieve fine powder; Get the formula ratio Radix Et Rhizoma Rhei, add its 6-10 times amount ethanol, supersound extraction, filter cleaner is concentrated near doing, and drying is pulverized, and sieves, and it is standby to get emodin and chrysophanol fine powder; Get recipe quantity Matrii Sulfas Exsiccatus, Cortex Cinnamomi respectively roguing pulverize, sieve to such an extent that Matrii Sulfas Exsiccatus and Cortex Cinnamomi fine powder are standby; Get recipe quantity Radix Ginseng, Ganoderma, micronizing gets fine powder after the roguing respectively; With above-mentioned six kinds of Chinese medicine fine powder uniform mixing, irradiation sterilization adds magnesium stearate, makes capsule or tablet.
This Chinese medicine composition of the present invention has purging heat to relax the bowels, invigorating the spleen and benefiting QI function, be used for the intestines and stomach excess-heat, temper clinically and lose diseases such as hyperlipidemia due to the void, constipation, abdominal distension and anorexia, obesity, can fundamentally treat constipation, and have no side effect, has the good clinical effect, treatment hyperlipidemia total effective rate reaches 97.8%, treatment total cure rate of habitual constipation and obvious effective rate 100%.
The specific embodiment
For better illustrating as follows for embodiment to the present invention:
Embodiment 1
Choose: 64 parts of Radix Et Rhizoma Rhei, 16 parts of Matrii Sulfas Exsiccatus, 10 parts of Radix Ginsengs, 2 parts of Ganodermas, 5 parts of Cortex Cinnamomis, Radix Glycyrrhizae is Chinese medicine composition raw material of the present invention for 15 parts.Preparation method is as follows:
Get the formula ratio Radix Glycyrrhizae, clean remove impurity, be ground into fine powder, add its 10 times of water gagings, 50 ℃ of supersound extraction 60 minutes (ultrasonic power 50W, supersonic frequency 30KHz), filter cleaner, the filtrate decompression vacuum concentration, vacuum ﹣ 0.08Mpa, temperature gets thick paste, 75-85 ℃ of dryings for 60 ℃, pulverize, cross 160 mesh sieves and get fine powder.Get the formula ratio Radix Et Rhizoma Rhei, add its 10 times amount ethanol, 70 ℃ of supersound extraction 2 hours (ultrasonic power 50W, supersonic frequency 30KHZ), filter and remove residue, 60 ℃ of normal pressures of filtrate are concentrated near dried, 60-65 ℃ of dryings of solids, pulverize, cross 160 mesh sieves, it is standby to get emodin and chrysophanol fine powder.
Get recipe quantity Matrii Sulfas Exsiccatus and Cortex Cinnamomi and distinguish the roguing pulverizing, it is standby that mistake 80 mesh sieves get the Matrii Sulfas Exsiccatus fine powder.Get recipe quantity Radix Ginseng, Ganoderma, micronizing gets fine powder after the roguing respectively.With above-mentioned six kinds of Chinese medicine fine powder uniform mixing, irradiation sterilization adds Chinese medicine gross weight 1% magnesium stearate, makes the capsule of 0.5 gram/grain, packing.
Contain emodin with emodin (C in this product every (0.5 gram)
15H
10O
5) and chrysophanol (C
15H
10O
4) total amount be no less than 2.70 milligrams.
Radix Et Rhizoma Rhei Determination on content method is a high-efficient liquid phase technique:
Chromatographic condition and system suitability test: with octadecylsilane chemically bonded silica is filler; Methanol-0.1% phosphoric acid solution (88:12) is a mobile phase; The detection wavelength is 254nm, and number of theoretical plate calculates by the emodin peak should be not less than 3500.
The preparation of reference substance solution: precision takes by weighing emodin, each 10mg of chrysophanol reference substance, puts respectively in the 50ml measuring bottle, with dissolve with methanol and be diluted to scale, shakes up; Precision is measured emodin solution 1ml, chrysophanol solution 2ml respectively, puts respectively in the same 250ml measuring bottle, adds methanol to scale, shakes up, and promptly gets (contain among the every 1ml of emodin among 8 μ g, the every 1ml of chrysophanol and contain 16 μ g).
The preparation of need testing solution: get the content under this product quantity variance item, mixing is got 0.2g, the accurate title, decide, and puts in the tool plug conical flask, the accurate methanol 25ml that adds, close plug claims to decide weight, reflux 30 minutes, put coldly, claim again to decide weight, supply the weight that subtracts mistake with methanol, shake up, filter, precision is measured filtrate 5ml, put in the round-bottomed flask, fling to methanol, add the 2.5mol/L sulfuric acid solution, supersound process 5 minutes adds chloroform 10ml again, reflux 1 hour, cooling in the dislocation separatory funnel, is used the minimum of chloroform washing container, washing liquid is incorporated in the separatory funnel, divides and gets chloroform layer, acid solution chloroform extraction 2 times, each 8ml, combined chloroform liquid dewaters in right amount with anhydrous sodium sulfate, in the chloroform solution dislocation tool plug conical flask, fling to chloroform, the accurate methanol 10ml that adds of residue, claim to decide weight, put slight fever dissolved residue in the water-bath, put cold after, claim again to decide weight, supply the weight that subtracts mistake, shake up with methanol, filter, get subsequent filtrate, promptly.
Algoscopy: accurate respectively reference substance solution and each 20 μ l of need testing solution of drawing, inject chromatograph of liquid, measure, promptly.
Per 0.5 gram contains the ginsenoside Rg in this product
1(C
42H
72O
14) and ginsenoside Re (C
48H
82O
18) total amount be no less than 0.17 milligram.
The ginsenoside Rg
1With ginsenoside Re's assay method be high-efficient liquid phase technique:
Chromatographic condition and system suitability test: with the octadecylsilane chemically bonded silica is filler; With the acetonitrile is mobile phase A, is Mobile phase B with water, and the regulation in the according to the form below is carried out gradient elution; The detection wavelength is 203nm.Number of theoretical plate is by the ginsenoside Rg
1The peak calculates should be not less than 6000.
The preparation of reference substance solution: precision takes by weighing the ginsenoside Rg
1Reference substance, ginsenoside Re's reference substance add methanol and make the mixed solution that every 1ml contains 0.2mg, shake up, promptly.
The preparation of need testing solution: get the about 1g of this product powder (crossing sieve No. four), the accurate title, decide, and puts in the apparatus,Soxhlet's, added the chloroform reflux 3 hours, and discarded chloroform liquid, medicinal residues volatilize solvent, move in the 100ml conical flask together with filtration paper cylinder, precision adds water-saturated n-butanol 50ml, close plug, and placement is spent the night, supersound process (power 250W, frequency 50Khz) 30 minutes, filter, discard filtrate just, precision is measured subsequent filtrate 25ml, put evaporate to dryness in the evaporating dish, residue adds dissolve with methanol and is transferred in the 5ml measuring bottle, adds methanol and is diluted to scale, shake up, filter, get subsequent filtrate, promptly.
Algoscopy: the accurate respectively reference substance solution 10 μ l that draw, inject chromatograph of liquid, measure, promptly.
The per 0.5 gram glycyrrhizic acid (C of this product
21H
22O
2) content must not be less than 6.0 milligrams.
The glycyrrhizic acid content assay method is a high-efficient liquid phase technique:
Chromatographic condition and system suitability test: with the octadecylsilane chemically bonded silica is filler; With the acetonitrile is mobile phase A, is Mobile phase B with 0.05% phosphoric acid solution, and the regulation in the according to the form below is carried out gradient elution; The detection wavelength is 237nm.Number of theoretical plate calculates by the liquirtin peak should be not less than 5000.
The preparation of reference substance solution: extracting liquorice acid ammonium reference substance is an amount of, and accurate the title decides, and adds 70% ethanol and makes the solution that every 1ml contains ammonium glycyrrhizinate 0.2mg respectively, promptly gets (glycyrrhizic acid weight=ammonium glycyrrhizinate weight/1.0207).
The preparation of need testing solution: get the about 0.2g of this product powder (crossing sieve No. three), the accurate title, decide, and puts in the tool plug conical flask, the accurate 70% ethanol 100ml that adds, close plug claims to decide weight, supersound process (power 250W, frequency 40Khz) 30 minutes is put cold, claim to decide weight again, supply the weight that subtracts mistake with 70% ethanol, shake up, filter, get subsequent filtrate, promptly.
Algoscopy: precision is drawn reference substance solution and is supplied each 10 μ l of test agent solution respectively, and the injection chromatograph of liquid is measured, promptly.
Embodiment 2
Choose: 168 parts of Radix Et Rhizoma Rhei, 30 parts of Matrii Sulfas Exsiccatus, 20 parts of Radix Ginsengs, 5 parts of Ganodermas, 25 parts of Cortex Cinnamomis, 30 parts in Radix Glycyrrhizae is Chinese medicine composition raw material of the present invention.Preparation method is as follows:
Get the formula ratio Radix Glycyrrhizae, clean remove impurity, be ground into fine powder, add its 8 times of water gagings, 50 ℃ of supersound extraction 80 minutes (ultrasonic power 50W, supersonic frequency 30KHz), filter cleaner, the filtrate decompression vacuum concentration, vacuum ﹣ 0.06Mpa, temperature gets thick paste, 75-85 ℃ of dryings for 70 ℃, pulverize, cross 160 mesh sieves and get fine powder.Get the formula ratio Radix Et Rhizoma Rhei, add its 8 times amount ethanol, 60 ℃ of supersound extraction 3 hours (ultrasonic power 50W, supersonic frequency 30KHZ), filter and remove residue, 65 ℃ of normal pressures of filtrate are concentrated near dried, 60-65 ℃ of dryings, pulverize, cross 160 mesh sieves, it is standby to get emodin and chrysophanol fine powder.
Get the roguing pulverizing respectively of recipe quantity Matrii Sulfas Exsiccatus, Cortex Cinnamomi, mistake 80 mesh sieves get Matrii Sulfas Exsiccatus and the Cortex Cinnamomi fine powder is standby.Get recipe quantity Radix Ginseng, Ganoderma, micronizing gets fine powder after the roguing respectively.With above-mentioned six kinds of Chinese medicine fine powder uniform mixing, irradiation sterilization adds the magnesium stearate of Chinese medicine gross weight 1%, makes the capsule of 0.5 gram/grain, packing.
Contain emodin with emodin (C in per 0.5 gram of this product
15H
10O
5) and chrysophanol (C
15H
10O
4) total amount be no less than 2.70 milligrams.Contain the ginsenoside Rg
1(C
42H
72O
14) and ginsenoside Re (C
48H
82O
18) total amount be no less than 0.17 milligram.Glycyrrhizic acid (C
21H
22O
2) content is no less than 6.0 milligrams.
Assay method is with embodiment 1.
Embodiment 3
Choose: 200 parts of Radix Et Rhizoma Rhei, 24 parts of Matrii Sulfas Exsiccatus, 16 parts of Radix Ginsengs, 3.5 parts of Ganodermas, 10 parts of Cortex Cinnamomis, 23 parts in Radix Glycyrrhizae is Chinese medicine composition raw material of the present invention.Preparation method is as follows:
Get the formula ratio Radix Glycyrrhizae, clean remove impurity, be ground into fine powder, add its 6 times of water gagings, 50 ℃ of supersound extraction 120 minutes (ultrasonic power 50W, supersonic frequency 30KHz), filter cleaner, the filtrate decompression vacuum concentration, vacuum ﹣ 0.065Mpa, temperature gets thick paste, 75-85 ℃ of dryings for 60-70 ℃, pulverize, cross 160 mesh sieves and get fine powder.Get the formula ratio Radix Et Rhizoma Rhei, add its 6 times amount ethanol, 55 ℃ of supersound extraction 4 hours (ultrasonic power 50W, supersonic frequency 30KHZ), filter and remove residue, 65 ℃ of normal pressures of filtrate are concentrated near dried, 60-65 ℃ of dryings, pulverize, cross 160 mesh sieves, it is standby to get emodin and chrysophanol fine powder.
Get the roguing pulverizing respectively of recipe quantity Matrii Sulfas Exsiccatus, Cortex Cinnamomi, 80 mesh sieves get Matrii Sulfas Exsiccatus excessively, the Cortex Cinnamomi fine powder is standby.Get recipe quantity Radix Ginseng, Ganoderma, micronizing gets fine powder after the roguing respectively.With above-mentioned six kinds of Chinese medicine fine powder uniform mixing, irradiation sterilization adds 1% magnesium stearate of Chinese medicine gross weight, makes the tablet of 0.5 gram/grain, packing.
Contain emodin with emodin (C in per 0.5 gram of this product
15H
10O
5) and chrysophanol (C
15H
10O
4) total amount be no less than 2.70 milligrams.Contain the ginsenoside Rg
1(C
42H
72O
14) and ginsenoside Re (C
48H
82O
18) total amount be no less than 0.17 milligram.Glycyrrhizic acid (C
21H
22O
2) content is no less than 6.0 milligrams.
Assay method is with embodiment 1.
Embodiment 4
Choose: 240 parts of Radix Et Rhizoma Rhei, 64 parts of Matrii Sulfas Exsiccatus, 40 parts of Radix Ginsengs, 5.5 parts of Ganodermas, 20 parts of Cortex Cinnamomis, 60 parts in Radix Glycyrrhizae is Chinese medicine composition raw material of the present invention.Preparation method is as follows:
Get the formula ratio Radix Glycyrrhizae, clean remove impurity, be ground into fine powder, add its 8 times of water gagings, 50 ℃ of supersound extraction 100 minutes (ultrasonic power 50W, supersonic frequency 30KHz), filter cleaner, the filtrate decompression vacuum concentration, vacuum ﹣ 0.07Mpa, temperature gets thick paste, 75-85 ℃ of dryings for 65-75 ℃, pulverize, cross 160 mesh sieves and get fine powder.Get the formula ratio Radix Et Rhizoma Rhei, add its 8 times amount ethanol, 70 ℃ of supersound extraction 2 hours (ultrasonic power 50W, supersonic frequency 30KHZ), filter and remove residue, filtrate is evaporated to closely for 50 ℃ and does 60-65 ℃ of dryings, pulverize, cross 160 mesh sieves, it is standby to get emodin and chrysophanol fine powder.
Get the roguing pulverizing respectively of recipe quantity Matrii Sulfas Exsiccatus, Cortex Cinnamomi, mistake 80 mesh sieves get Matrii Sulfas Exsiccatus and the Cortex Cinnamomi fine powder is standby.Get recipe quantity Radix Ginseng, Ganoderma, micronizing gets fine powder after the roguing respectively.With above-mentioned six kinds of Chinese medicine fine powder uniform mixing, irradiation sterilization adds the magnesium stearate of Chinese medicine gross weight 1%, makes the capsule of 0.5 gram/grain, packing.
Contain emodin with emodin (C in per 0.5 gram of this product
15H
10O
5) and chrysophanol (C
15H
10O
4) total amount be no less than 2.70 milligrams.Contain the ginsenoside Rg
1(C
42H
72O
14) and ginsenoside Re (C
48H
82O
18) total amount be no less than 0.17 milligram.Glycyrrhizic acid (C
21H
22O
2) content is no less than 6.0 milligrams.
Assay method is with embodiment 1.
Embodiment 5
Choose: 190 parts of Radix Et Rhizoma Rhei, 48 parts of Matrii Sulfas Exsiccatus, 30 parts of Radix Ginsengs, 6 parts of Ganodermas, 15 parts of Cortex Cinnamomis, 45 parts in Radix Glycyrrhizae is Chinese medicine composition raw material of the present invention.Preparation method is as follows:
Get the formula ratio Radix Glycyrrhizae, clean remove impurity, be ground into fine powder, add its 10 times of water gagings, 50 ℃ of supersound extraction 70 minutes (ultrasonic power 50W, supersonic frequency 30KHz), filter cleaner, the filtrate decompression vacuum concentration, vacuum ﹣ 0.065Mpa, temperature gets thick paste, 75-85 ℃ of dryings for 70-80 ℃, pulverize, cross 160 mesh sieves and get fine powder.Get the formula ratio Radix Et Rhizoma Rhei, add 7 times of amount ethanol, 65 ℃ of supersound extraction 3.5 hours (ultrasonic power 50W, supersonic frequency 30KHZ), filter and remove residue, filtrate is evaporated to closely for 55 ℃ and does 60-65 ℃ of dryings, pulverize, cross 160 mesh sieves, it is standby to get emodin and chrysophanol fine powder.
Get the roguing pulverizing respectively of recipe quantity Matrii Sulfas Exsiccatus, Cortex Cinnamomi, mistake 80 mesh sieves get Matrii Sulfas Exsiccatus and the Cortex Cinnamomi fine powder is standby.Get recipe quantity Radix Ginseng, Ganoderma, micronizing gets fine powder after the roguing respectively.With above-mentioned six kinds of Chinese medicine fine powder uniform mixing, irradiation sterilization adds the magnesium stearate of Chinese medicine gross weight 1%, makes the coated tablet of 0.25 gram/grain, packing.
Contain emodin with emodin (C in per 0.5 gram of this product
15H
10O
5) and chrysophanol (C
15H
10O
4) total amount must not be less than 2.70 milligrams.Contain the ginsenoside Rg
1(C
42H
72O
14) and ginsenoside Re (C
48H
82O
18) total amount be no less than 0.17 milligram.Glycyrrhizic acid (C
21H
22O
2) content is no less than 6.0 milligrams.
Assay method is with embodiment 1.
Chinese medicine composition blood fat reducing relieving constipation capsule of the present invention (pharmaceutical formulation: capsule, every 0.5g) clinical test results is as follows:
Treatment hyperlipidemia clinical test results:
Case is selected:
Select case 360 examples altogether, 120 examples of wherein being in hospital, non-140 examples of being in hospital.In selected case, male's 220 examples, women's 140 examples, 36 years old of age minimum, maximum 68 years old, 52 years old mean age.
Therapeutic Method: oral, each 6, each once serve on five days sooner or later, adjusts dosage according to clinical symptoms after five days, and 4 weeks were a course of treatment, added up curative effect after the course of treatment.
Curative effect observation: blood fat is measured in blood drawing.
Clinical development standard: with reference to the hyperlipidemia criterion of therapeutical effect of regulation in " People's Republic of China's traditional Chinese medical science industry standard disease of tcm diagnosis criterion of therapeutical effect " (State Administration of Traditional Chinese Medicine's in June, 1994 issue).
Clinical test results:
Treatment constipation clinical test results:
Case is selected:
Select case 300 examples altogether, 61 examples of wherein being in hospital, non-239 examples of being in hospital.In the selected case, male's 180 examples, women's 120 examples, 36 years old of age minimum, maximum 72 years old, 59 years old mean age.
Therapeutic Method: oral, each 6, one day 2 times, 1 week was a course of treatment, adjusted dosage according to clinical symptoms, added up curative effect after the course of treatment.
Curative effect observation: defecation frequency, defecation time, just matter first, defecation effort situation, Asiatic water closet pan time.
Clinical development standard: with reference to the constipation criterion of therapeutical effect of regulation in " People's Republic of China's traditional Chinese medical science industry standard disease of tcm diagnosis criterion of therapeutical effect " (State Administration of Traditional Chinese Medicine's in June, 1994 issue).
Clinical test results:
Effective case 290 examples, result such as following table:
Model case:
1, Chen, the man, 52 years old, the cadre, dizziness, tired, abdominal distention is month surplus, health check-up: refreshing clear, obesity, cardiopulmonary are no abnormal, and abdominal distention is and soft, and liver, palpation of spleen are not noted, BP15/10.5Kpa, red tongue, moist and slippery fur is greasy, arteries and veins bone number.The three fat TC6.4mmol/L that have a blood test, TG2.9 mmol/L, HDL-C0.52 mmol/L, diagnosis: hyperlipemia (Chinese medical discrimination: expectorant is turbid to be checked), take blood fat reducing relieving constipation capsule, each 6, every day 2 times, service once second day ante cibum sooner or later, defecate 5 times, the abdomen hypodynia is advised its decrement, beginning in the 3rd day, each 3, every day 2 times, early, took medicine in one hour after the supper, stool is multiple normal, and stomachache disappears, around serveing on, above-mentioned symptom obviously alleviates, check blood fat TC5.6mmol/L, TG1.7 mmol/L, HDL-C1.1 mmol/L, thin white fur of tongue, stringy pulse is slow, reaches the clinic control standard.
2, what certain, the man, 63 years old, the cadre because of recurrent dizziness 2 years, increased the weight of two days, after being in hospital, had a medical check-up: refreshing clear, swallow red, heart rate 82 times/minute, A
2＞P
2, two lungs are no abnormal, and abdomen is soft, 0.5cm under the liver rib.The fat TC6.5mmol/L that has a blood test, TG7.29 mmol/L, HDL-C1.85 mmol/L, promptly take blood fat reducing relieving constipation capsule, every day 2 times, each 6, change every day 1 time after 5 days into, serve on for 4 weeks, dizziness, Mental fatigue, numb limbs and tense tendons obviously improves, the fat TC3.5mmol/L that has a blood test, TG1.51 mmol/L, HDL-C2.6 mmol/L reaches the clinic control standard.
3, Ke so-and-so, woman, 53 years old, teacher.Time sense is dizzy, numb limbs and tense tendons and sleeping not good enough 2 years, and often have constipation or defecation not smooth.Health check-up: the fat bodily form, BP20/12.5Kpa, heart rate 74 times/minute, rule is whole, no pathologic noise, two lungs are clear, and abdomen is flat soft, and the liver spleen does not reach, and it is normal that extremity are looked into muscular strength, and the tendon reflection exists, and does not draw the pathology neural reflex.Survey body weight 58.9kg, the fat TC7.27mmol/L that has a blood test, TG2.31 mmol/L receives treatment, give oral blood fat reducing relieving constipation capsule, begin each 6, every day early, service once before the supper, serve on 5 days, fasting meat in these 5 days, bean product, change into after 5 days sleep every day before 6 of clothes, continued clothes 23 days, patient's back second all symptoms of taking medicine begin to alleviate, especially alleviate obviously with dizziness, symptom disappears substantially after the 3rd week, and period in a medicine has laxativeness, and drug withdrawal continues after 1-2 days to take medicine again during diarrhoea, finish the back body weight course of treatment and reduce to 57.0kg, TC is 4.58mmol/L, and TG is 1.67 mmol/L, reaches the clinic control standard.
4, beam so-and-so, woman, 52 years old, peasant.Constipation 15 years, defecation time once was the sheep stool shape in 5-7 days more, at ordinary times with inferior belly gas pain, time companion's bleeding hemorrhoids.Have a medical check-up: refreshing clear, cardiopulmonary are no abnormal, and abdomen is soft, and the liver spleen does not touch, and left lower quadrant can touch hard scybalum, no tenderness, and red tongue, yellow fur is done, slippery and rapid pulse.Diagnosis: habitual constipation (functional constipation disease), give blood fat reducing relieving constipation capsule oral, each 6, divide early, evening is oral on an empty stomach every day 2 times, serve on three days after.Defecate every day 3-5 times, with slight stomachache, yellowish urine, medication changes each 3 into, every day 2 times, early, late (medicine) being taken before meal once, serve on 3 days, stool is shaped once a day, nothing stomachache, body of the tongue are changeed light red, yellow commentaries on classics and are approached white, moderate pulse, clinical symptom disappearance, the tongue arteries and veins is normal, blood, routine urinalysis are checked no abnormal, reach the clinical recovery standard.
Claims (6)
1. a Chinese medicine blood fat reducing relieving constipation capsule is characterized in that, is prepared from by following raw materials according, and each component is in weight portion:
Radix Et Rhizoma Rhei 32---50 parts of 320 parts of Matrii Sulfas Exsiccatus 8---80 parts of Radix Ginsengs 5---
Ganoderma 1---75 parts of 10 portions of Cortex Cinnamomis 2.5---25 portions of Radix Glycyrrhizaes 7.5---.
2. according to claims 1 described Chinese medicinal capsule, it is characterized in that crude drug is preferably as follows component:
15 parts in 5 portions of Radix Glycyrrhizaes of 2 portions of Cortex Cinnamomis of 10 portions of Ganodermas of 16 parts of Radix Ginsengs of 64 parts of Matrii Sulfas Exsiccatus of Radix Et Rhizoma Rhei.
3. according to claims 1 or 2 described Chinese medicinal capsules, it is characterized in that per 0.5 gram contains Radix Et Rhizoma Rhei and is no less than 2.70 milligrams in the total amount of emodin and chrysophanol in the described Chinese medicine composition.
4. according to claims 1 or 2 described Chinese medicinal capsules, it is characterized in that per 0.5 gram contains Radix Ginseng with the ginsenoside Rg in the described Chinese medicine composition
1Be no less than 0.17 milligram with ginsenoside Re's total amount meter.
5. according to claims 1 or 2 described Chinese medicinal capsules, it is characterized in that per 0.5 gram glycyrrhizic acid content is no less than 6.0 milligrams in the described Chinese medicine composition.
6. one of them described Chinese medicinal capsule of preparation claims 1-5 is characterized in that, prepares by following step:
Get the formula ratio Radix Glycyrrhizae, clean remove impurity, be ground into fine powder, add its 6-10 times of water gagings, supersound extraction, filter cleaner, the filtrate decompression vacuum concentration gets thick paste, drying is pulverized, sieve fine powder; Get the formula ratio Radix Et Rhizoma Rhei, add its 6-10 times amount ethanol, supersound extraction, filter cleaner is concentrated near doing, and drying is pulverized, and sieves, and it is standby to get emodin and chrysophanol fine powder; Get recipe quantity Matrii Sulfas Exsiccatus, Cortex Cinnamomi respectively roguing pulverize, sieve to such an extent that Matrii Sulfas Exsiccatus and Cortex Cinnamomi fine powder are standby; Get recipe quantity Radix Ginseng, Ganoderma, micronizing gets fine powder after the roguing respectively; With above-mentioned six kinds of Chinese medicine fine powder uniform mixing, irradiation sterilization adds magnesium stearate, makes capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100411486A CN102133273B (en) | 2010-12-29 | 2011-02-21 | Traditional Chinese medicine lipid-lowing and catharsis capsule and preparation method thereof |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010610619.6 | 2010-12-29 | ||
| CN201010610619 | 2010-12-29 | ||
| CN2011100411486A CN102133273B (en) | 2010-12-29 | 2011-02-21 | Traditional Chinese medicine lipid-lowing and catharsis capsule and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102133273A true CN102133273A (en) | 2011-07-27 |
| CN102133273B CN102133273B (en) | 2012-10-31 |
Family
ID=44293286
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011100411486A Active CN102133273B (en) | 2010-12-29 | 2011-02-21 | Traditional Chinese medicine lipid-lowing and catharsis capsule and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102133273B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103316122A (en) * | 2012-03-21 | 2013-09-25 | 四川荣州动物药业有限公司 | Preparation method for ultramicro powder of pig-strengthening powder |
| CN103550227A (en) * | 2013-11-22 | 2014-02-05 | 李文芝 | Method for treating diabetes by combining traditional Chinese medicine and western medicine |
| CN104351801A (en) * | 2014-10-24 | 2015-02-18 | 桂林丰润莱生物科技有限公司 | Sweet tea food capable of reducing blood fat and preparation method of sweet tea food |
| CN104706838A (en) * | 2015-03-26 | 2015-06-17 | 王凯 | Preparation method of blood-activating, stasis-removing, lipid-lowering and fat-reducing capsule |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1887334A (en) * | 2005-06-27 | 2007-01-03 | 成都康弘科技实业（集团）有限公司 | Cathartic medicine composition |
-
2011
- 2011-02-21 CN CN2011100411486A patent/CN102133273B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1887334A (en) * | 2005-06-27 | 2007-01-03 | 成都康弘科技实业（集团）有限公司 | Cathartic medicine composition |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103316122A (en) * | 2012-03-21 | 2013-09-25 | 四川荣州动物药业有限公司 | Preparation method for ultramicro powder of pig-strengthening powder |
| CN103550227A (en) * | 2013-11-22 | 2014-02-05 | 李文芝 | Method for treating diabetes by combining traditional Chinese medicine and western medicine |
| CN104351801A (en) * | 2014-10-24 | 2015-02-18 | 桂林丰润莱生物科技有限公司 | Sweet tea food capable of reducing blood fat and preparation method of sweet tea food |
| CN104706838A (en) * | 2015-03-26 | 2015-06-17 | 王凯 | Preparation method of blood-activating, stasis-removing, lipid-lowering and fat-reducing capsule |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102133273B (en) | 2012-10-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109674958B (en) | Traditional Chinese medicine composition with effect of reducing uric acid and preparation method and application thereof | |
| WO2007009291A1 (en) | A pharmaceutical composition of traditional chineses medicine for treating rheumatoid arthritis and preparation thereof | |
| WO2007006203A1 (en) | A capsule formulation for treating hypertension and coronary heart disease and process for preparation thereof | |
| CN104922543A (en) | Medicine composite for treating amenorrhea and preparation method thereof | |
| CN102626468B (en) | Traditional Chinese medicine combination for treating hepatitis B and preparing method and application thereof | |
| CN102133273B (en) | Traditional Chinese medicine lipid-lowing and catharsis capsule and preparation method thereof | |
| CN104436065A (en) | Traditional Chinese medicine for treating or preventing radiographic contrast nephropathy for imaging department and preparation method | |
| CN101461932B (en) | Medicament composition for treating children's damp-heat diarrhea induced by spleen insufficiency and preparation method thereof | |
| CN100571761C (en) | A kind of Chinese medicine composition and preparation method for the treatment of hepatopathy | |
| CN103690582A (en) | Composition containing dendrobium polysaccharide and atractylodes oil and application thereof | |
| CN101485835B (en) | Medicament composition for treating ostarthritis as well as preparation method and detection method | |
| CN101020016B (en) | Medicine for treating fracture and injured tendon and its preparation | |
| CN105434840A (en) | Manufacturing method for Chuanshentong preparation | |
| CN100333758C (en) | Gout resisting Chinese medicine composition and its prepn process | |
| CN1246031C (en) | Chinese patent drug-Fuyan capsdule for treating chronic pelvic inflammation | |
| CN101850065A (en) | Chinese medicinal composition for treating gout | |
| CN107519430A (en) | A kind of Chinese medicine composition for treating PBC and its preparation method and application | |
| CN100482266C (en) | Medical composite prepared by sarcandra and oldenlandia | |
| CN101837093A (en) | Chinese medicinal composition for curing gout | |
| CN111588763A (en) | Thrombus dredging medicine, preparation method and content determination method | |
| CN105012522A (en) | Kidney-nourishing brain-fortifying traditional Chinese medicine, preparation method and purpose | |
| CN1977888B (en) | Medicinal composition of baicalin, ganoderma lucidum and salvia miltrorrhiza | |
| CN115957272B (en) | Pharmaceutical composition for eliminating dampness, preparation and application thereof | |
| CN103191243A (en) | Application of medicament composition composed of coptis chinensis and fructus evodiae and preparation method of medicament composition | |
| CN108704036A (en) | A kind of Chinese traditional compound medicine and preparation method thereof for treating gout |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| PP01 | Preservation of patent right |
Effective date of registration: 20190809 Granted publication date: 20121031 |
|
| PP01 | Preservation of patent right | ||
| PD01 | Discharge of preservation of patent |
Date of cancellation: 20220809 Granted publication date: 20121031 |
|
| PD01 | Discharge of preservation of patent | ||
| PP01 | Preservation of patent right |
Effective date of registration: 20220809 Granted publication date: 20121031 |
|
| PP01 | Preservation of patent right |