CN103830426A - Traditional Chinese medicine composition for treating angiitis - Google Patents
Traditional Chinese medicine composition for treating angiitis Download PDFInfo
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- CN103830426A CN103830426A CN201410123314.0A CN201410123314A CN103830426A CN 103830426 A CN103830426 A CN 103830426A CN 201410123314 A CN201410123314 A CN 201410123314A CN 103830426 A CN103830426 A CN 103830426A
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Abstract
The invention provides a traditional Chinese medicine composition for treating angiitis. The composition comprises components such as beautiful millettia root, prepared rehmannia glutinosa, angelica sinensis, achyranthes root, caulis spatholobi, oldenlandia diffusa, zanthoxylum nitidum and anemonis raddeanae. Compared with a traditional Chinese medicine mixture which is frequently used in clinical application, the traditional Chinese medicine composition provided by the invention is good in stability, guaranteed in medicine effect and convenient to use since an extraction, purification and preparation process is combined with traditional Chinese medicine theories and clinical application requirements.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to one and be used for the treatment of vasculitic Chinese medicine composition.
Background technology
Thromboangiitis obliterans (vasculitis) is one of peripheral arterial occlusive disease common type, that one betides the medium and small arteriovenous aseptic vascular inflammation disease of extremity, mainly involve the little medium vessels of distal limbs, nerve, especially lower limb vascular, its blood vessel wall can produce stage and nonsuppurative inflammation, often, with intracavity thrombosis, can cause limbs and occur the diseases such as row of crossing mountains at pain, ischemia, intermittence, when serious, can cause extremity ulcer or necrosis.Patient Duo Yin treats and is unsuccessfully forced to amputation, and disability has a strong impact on quality of life of patient, has brought white elephant to patient family and society.Its course of disease is slow, and etiology unknown has now become one of disease that current era difficulty captures.
The clinical treatment measure that vasculitis is taked at present has traditional remedies, operative treatment, vascular treatment method (vasodilation art, reconstructive vascular operation), gene therapy, immunization therapy, blood purification etc.All there is limitation in various degree in existing Therapeutic Method, vasculitic therapeutic effect is not satisfactory clinically.Reduce the difficult problem that such disease amputation rate causing and quality of life of improving patient becomes vascular operation treatment and the solution of internal medicine treatment urgent need.Fully the natural resources of Chinese medicinal materials of development and utilization China's abundant, selects rational medical material to study, and effectively brings into play Chinese medicine advantage, and to preventing and treating, vasculitis has important practical significance and social meaning.
Summary of the invention
The object of the invention is the technical problem that will solve for above, provide a kind of and can effectively treat that vasculitis, active constituent content are high, steady quality, patient's Chinese medicine composition easy to use.
To achieve these goals, the invention provides one and treat vasculitic Chinese medicine composition, it comprises following component: Millettia Speciosa 2 weight portions, Radix Rehmanniae Preparata 2 weight portions, Radix Angelicae Sinensis 1 weight portion, Radix Achyranthis Bidentatae 1 weight portion, Caulis Spatholobi 2 weight portions, Herba Hedyotidis Diffusae 1 weight portion, Radix Zanthoxyli 1 weight portion, Rhizoma Anemones Raddeanae 1 weight portion;
And make according to following steps:
Step 1: get Millettia Speciosa, Radix Angelicae Sinensis, after soaking, use extraction by steam distillation volatile oil, the volatile oil of acquisition is formed to volatile oil beta cyclodextrin inclusion complex with beta-cyclodextrin inclusion compound, aqueous solution after distillation filters, for subsequent use, in medicinal residues, add Rhizoma Anemones Raddeanae, Caulis Spatholobi, then add alcohol reflux, filter, filtrate recycling ethanol concentrating under reduced pressure become clear paste A for subsequent use;
Step 2: get Radix Rehmanniae Preparata, Radix Achyranthis Bidentatae, Herba Hedyotidis Diffusae, Radix Zanthoxyli, add supersound extraction after the water soaking of pH=3～4.5, extracting liquid filtering is for subsequent use to container; To the water that continues to add pH=6～8 in medicinal residues, supersound extraction, extracting liquid filtering is for subsequent use to container; Again to the water that continues to add pH=8～9 in medicinal residues, supersound extraction, extracting liquid filtering is for subsequent use to container; Merge the aqueous solution after filtrate and the distillation that obtains of step 1 of extracting for three times, concentrating under reduced pressure becomes clear paste B for subsequent use;
Step 3: the clear paste B that the clear paste A that step 1 is obtained and step 2 obtain mixes, and vacuum dehydrating at lower temperature, is ground into fine powder, adds volatile oil beta cyclodextrin inclusion complex and the proper auxiliary materials that step 1 obtains to be prepared into granule.
Preferably, in step 1, be 7:1 for soaking the water of Millettia Speciosa and Radix Angelicae Sinensis and the volume ratio of medical material.
Preferably, in step 1, be 4:1 for the beta-schardinger dextrin-of enclose and the volume ratio of volatile oil.
Preferably, in step 1, medicinal residues add Rhizoma Anemones Raddeanae, Caulis Spatholobi, add 60% alcohol reflux 3 times of 8 times of volumes, each 2 hours at every turn.
Preferably, in step 2, when each supersound extraction, the water adding and the volume ratio of medicinal residues are 8:1.
Preferably, in step 2, when supersound extraction, add the water soaking of pH=3.5 after 0.5 hour, to carry out supersound extraction for the first time.
Preferably, in step 2, when supersound extraction, add the water of pH=7 for the second time.
Preferably, in step 2, when supersound extraction, add the water of pH=8.5 for the third time.
Preferably, in step 2, the time of each supersound extraction is 1 hour.
As most preferred a kind of embodiment, Chinese medicine composition of the present invention makes according to following steps:
Step 1: get Millettia Speciosa, Radix Angelicae Sinensis, add the water soaking of 7 times of medical material volumes after 0.5 hour, with 1.5 hours extraction volatile oil of steam distillation distillation, the volatile oil obtaining is formed to volatile oil beta cyclodextrin inclusion complex with 4 times of amount beta-cyclodextrin inclusion compounds, aqueous solution after distillation filters, for subsequent use, in medicinal residues, add Rhizoma Anemones Raddeanae, Caulis Spatholobi, add 60% alcohol reflux 3 times of 8 times of volumes at every turn, each 2 hours, filter, after filtrate merges, reclaiming ethanol and becoming relative density at 60 ℃ of concentrating under reduced pressure is that 1.20 clear paste A is for subsequent use;
Step 2: get Radix Rehmanniae Preparata, Radix Achyranthis Bidentatae, Herba Hedyotidis Diffusae, Radix Zanthoxyli, the water soaking of pH=3.5 that adds 8 times of volumes supersound extraction 1 hour after 0.5 hour, extracting liquid filtering is for subsequent use to container; To the water that continues the pH=7 that adds 8 times of volumes in medicinal residues, supersound extraction 1 hour, extracting liquid filtering is for subsequent use to container; Again to the water that continues the pH=8.5 that adds 8 times of volumes in medicinal residues, supersound extraction 1 hour, extracting liquid filtering is for subsequent use to container; Merge the aqueous solution after filtrate and the distillation that obtains of step 1 of extracting for three times, becoming relative density at 60 ℃ of concentrating under reduced pressure is that 1.20 clear paste B is for subsequent use;
Step 3: the clear paste B that the clear paste A that step 1 is obtained and step 2 obtain mixes, and vacuum dehydrating at lower temperature, is ground into fine powder, adds volatile oil beta cyclodextrin inclusion complex and the proper auxiliary materials that step 1 obtains to be prepared into granule.
Millettia Speciosa is the root of pulse family Millettia plant beautiful millettia Millettia specisoa Champ., and nature and flavor are sweet, flat.Main effect tonify deficiency lung moistening, strong muscle is active.
Radix Rehmanniae Preparata is that the tuber of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa is concocted and formed through processing, and nature and flavor are sweet, tepor.Return liver, kidney channel.Main effect YIN nourishing of enriching blood, beneficial essence is filled out marrow.
When being classified as the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels., nature and flavor sweet, acrid, warm.Return liver, the heart, spleen channel.Main effect is enriched blood and is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Radix Achyranthis Bidentatae is the dry root of amaranthaceous plant Radix Achyranthis Bidentatae Achyranthes bidentata Blume., and nature and flavor hardship, acid are flat.Return liver, kidney channel.Main effect invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.
Caulis Spatholobi is the dry rattan of leguminous plant spatholobus suberectus (Caulis Sargentodoxae, Radix seu Caulis Verntilaginis Leiocarpae, SANYE Caulis Spatholobi, nine layers of wind) Spatholobus suberectus Dunn.Nature and flavor hardship, sweet, temperature.Return liver, kidney channel.Main effect is enriched blood, invigorates blood circulation, and dredging collateral.
Herba Hedyotidis Diffusae is the herb of Rubiaceae plants of Hedyotis Herba Hedyotidis Diffusae Hedyotis diffusa Willd.Nature and flavor are sweet, light, cool.Return stomach, large intestine, small intestine meridian.Main effect is heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain
Radix Zanthoxyli is root or the branch and leaf of rutaceae Radix Zanthoxyli Zanthoxylum nitidum (Roxb.) DC., and nature and flavor are arduous, and temperature is slightly poisonous.Main effect dispelling wind and removing obstruction in the collateral, removing dampness to relieve pain, subduing swelling and detoxicating.
Rhizoma Anemones Raddeanae is the dry rhizome of ranunculaceae plant anemone raddeana Regel Anemone raddeana Regel.Nature and flavor are pungent, heat; Poisonous.Return spleen channel.Main effect is wind-damp dispelling, subduing inflammation.
Chinese medicine composition of the present invention is made up of eight taste Chinese crude drugs such as Millettia Speciosa, Radix Angelicae Sinensis, Caulis Spatholobis, reasonable recipe; Wherein in Millettia Speciosa, Radix Angelicae Sinensis two taste medical materials, contain a large amount of volatile oil, water solublity and alcohol dissolubility effective ingredient, by traditional Chinese medicine theory, Radix Angelicae Sinensis sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, invigorating middle warmer has, in row, has benefit, is key medicine in blood; Therefore its volatile ingredient should be one of main composition, thus first carried out after extraction by steam distillation volatile oil, and adopt beta-cyclodextrin inclusion compound, to guarantee the operability of its stability and subsequent technique.Aqueous solution is continued to employ, and then medicinal residues is carried out together with Rhizoma Anemones Raddeanae, Caulis Spatholobi to alcohol extraction.So both can reduce operating procedure, can extract as far as possible again effective ingredient.
Herba Hedyotidis Diffusae, Radix Zanthoxyli, Radix Rehmanniae Preparata, Radix Achyranthis Bidentatae four taste Chinese crude drugs, its main component is respectively organic acid, alkaloid, polysaccharide, sterol etc., the present invention adopts the water of three kinds of different pH to carry out ultrasonic extract at low temperature successively, realize the mixed extraction of " functional component ", both guaranteed the activity of functional component, also reduce separating out of invalid impurity, played refining object.
Cold drying after above extract is mixed, add after volatile oil beta cyclodextrin inclusion complex and proper auxiliary materials with the agent of existing method granulation, after adding warm water to dissolve when use, take, easy to use, both the unstability of having avoided liquid preparation to store, meet again " soup person swing also " of Chinese medicine, the effect feature of decoction for removing serious disease.
Visible, provided by the inventionly be used for the treatment of vasculitic Chinese medicine preparation compared with herb mixture conventional in clinical practice, it extracts purification, preparation process combines traditional Chinese medicine theory and clinical practice requirement, and stability is better, drug effect is more guaranteed, uses more convenient.
The specific embodiment
Below in conjunction with specific embodiment, technical scheme of the present invention is described in further detail, but protection scope of the present invention is not limited in following examples.
Embodiment 1
Weigh each component by following formula: Millettia Speciosa 12g, Radix Rehmanniae Preparata 12g, Radix Angelicae Sinensis 6g, Radix Achyranthis Bidentatae 6g, Caulis Spatholobi 12g, Herba Hedyotidis Diffusae 6g, Radix Zanthoxyli 6g, Rhizoma Anemones Raddeanae 6g.
Prepare according to the following steps Chinese medicine preparation:
1. get Millettia Speciosa, Radix Angelicae Sinensis, add the water soaking of 7 times of medical material volumes after 0.5 hour, with 1.5 hours extraction volatile oil of steam distillation distillation, the volatile oil obtaining is formed to volatile oil beta cyclodextrin inclusion complex with 4 times of amount beta-cyclodextrin inclusion compounds, aqueous solution after distillation filters, for subsequent use, in medicinal residues, add Rhizoma Anemones Raddeanae, Caulis Spatholobi, add 60% alcohol reflux 3 times of 8 times of volumes at every turn, each 2 hours, filter, after filtrate merges, reclaiming ethanol and becoming relative density at 60 ℃ of concentrating under reduced pressure is that 1.20 clear paste A is for subsequent use;
2. get Radix Rehmanniae Preparata, Radix Achyranthis Bidentatae, Herba Hedyotidis Diffusae, Radix Zanthoxyli, the water soaking of pH=3.5 that adds 8 times of volumes supersound extraction 1 hour after 0.5 hour, extracting liquid filtering is for subsequent use to container; To the water that continues the pH=7 that adds 8 times of volumes in medicinal residues, supersound extraction 1 hour, extracting liquid filtering is for subsequent use to container; Again to the water that continues the pH=8.5 that adds 8 times of volumes in medicinal residues, supersound extraction 1 hour, extracting liquid filtering is for subsequent use to container; Merge the aqueous solution after filtrate and the distillation that obtains of step 1 of extracting for three times, becoming relative density at 60 ℃ of concentrating under reduced pressure is that 1.20 clear paste B is for subsequent use;
3. the clear paste B that clear paste A step 1 being obtained and step 2 obtain mixes, and vacuum dehydrating at lower temperature, is ground into fine powder, adds volatile oil beta cyclodextrin inclusion complex and the appropriate Icing Sugar that step 1 obtains to be prepared into according to a conventional method granule.
Embodiment 2
Weigh each component by following formula: Millettia Speciosa 12g, Radix Rehmanniae Preparata 12g, Radix Angelicae Sinensis 6g, Radix Achyranthis Bidentatae 6g, Caulis Spatholobi 12g, Herba Hedyotidis Diffusae 6g, Radix Zanthoxyli 6g, Rhizoma Anemones Raddeanae 6g.
Prepare according to the following steps Chinese medicine preparation:
1. get Millettia Speciosa, Radix Angelicae Sinensis, add the water soaking of 7 times of medical material volumes after 0.5 hour, with 1.5 hours extraction volatile oil of steam distillation distillation, the volatile oil obtaining is formed to volatile oil beta cyclodextrin inclusion complex with 4 times of amount beta-cyclodextrin inclusion compounds, aqueous solution after distillation filters, for subsequent use, in medicinal residues, add Rhizoma Anemones Raddeanae, Caulis Spatholobi, add 60% alcohol reflux 3 times of 8 times of volumes at every turn, each 2 hours, filter, after filtrate merges, reclaiming ethanol and becoming relative density at 60 ℃ of concentrating under reduced pressure is that 1.20 clear paste A is for subsequent use;
2. get Radix Rehmanniae Preparata, Radix Achyranthis Bidentatae, Herba Hedyotidis Diffusae, Radix Zanthoxyli, the water soaking of pH=3 that adds 8 times of volumes supersound extraction 1 hour after 0.5 hour, extracting liquid filtering is for subsequent use to container; To the water that continues the pH=6 that adds 8 times of volumes in medicinal residues, supersound extraction 1 hour, extracting liquid filtering is for subsequent use to container; Again to the water that continues the pH=9 that adds 8 times of volumes in medicinal residues, supersound extraction 1 hour, extracting liquid filtering is for subsequent use to container; Merge the aqueous solution after filtrate and the distillation that obtains of step 1 of extracting for three times, becoming relative density at 60 ℃ of concentrating under reduced pressure is that 1.20 clear paste B is for subsequent use;
3. the clear paste B that clear paste A step 1 being obtained and step 2 obtain mixes, and vacuum dehydrating at lower temperature, is ground into fine powder, adds volatile oil beta cyclodextrin inclusion complex and the appropriate Icing Sugar that step 1 obtains to be prepared into according to a conventional method granule.
Embodiment 3
Weigh each component by following formula: Millettia Speciosa 12g, Radix Rehmanniae Preparata 12g, Radix Angelicae Sinensis 6g, Radix Achyranthis Bidentatae 6g, Caulis Spatholobi 12g, Herba Hedyotidis Diffusae 6g, Radix Zanthoxyli 6g, Rhizoma Anemones Raddeanae 6g.
Prepare according to the following steps Chinese medicine preparation:
1. get Millettia Speciosa, Radix Angelicae Sinensis, add the water soaking of 7 times of medical material volumes after 0.5 hour, with 1.5 hours extraction volatile oil of steam distillation distillation, the volatile oil obtaining is formed to volatile oil beta cyclodextrin inclusion complex with 4 times of amount beta-cyclodextrin inclusion compounds, aqueous solution after distillation filters, for subsequent use, in medicinal residues, add Rhizoma Anemones Raddeanae, Caulis Spatholobi, add 60% alcohol reflux 3 times of 8 times of volumes at every turn, each 2 hours, filter, after filtrate merges, reclaiming ethanol and becoming relative density at 60 ℃ of concentrating under reduced pressure is that 1.20 clear paste A is for subsequent use;
2. get Radix Rehmanniae Preparata, Radix Achyranthis Bidentatae, Herba Hedyotidis Diffusae, Radix Zanthoxyli, the water soaking of pH=4.5 that adds 8 times of volumes supersound extraction 1 hour after 0.5 hour, extracting liquid filtering is for subsequent use to container; To the water that continues the pH=8 that adds 8 times of volumes in medicinal residues, supersound extraction 1 hour, extracting liquid filtering is for subsequent use to container; Again to the water that continues the pH=8 that adds 8 times of volumes in medicinal residues, supersound extraction 1 hour, extracting liquid filtering is for subsequent use to container; Merge the aqueous solution after filtrate and the distillation that obtains of step 1 of extracting for three times, becoming relative density at 60 ℃ of concentrating under reduced pressure is that 1.20 clear paste B is for subsequent use;
3. the clear paste B that clear paste A step 1 being obtained and step 2 obtain mixes, and vacuum dehydrating at lower temperature, is ground into fine powder, adds volatile oil beta cyclodextrin inclusion complex and the appropriate Icing Sugar that step 1 obtains to be prepared into according to a conventional method granule.
Comparative example (mixture)
Water decocting preparation technique routinely, take Millettia Speciosa 12g, Radix Rehmanniae Preparata 12g, Radix Angelicae Sinensis 6g, Radix Achyranthis Bidentatae 6g, Caulis Spatholobi 12g, Herba Hedyotidis Diffusae 6g, Radix Zanthoxyli 6g, Rhizoma Anemones Raddeanae 6g, add appropriate water boiling and extraction 3 times, each 1.5 hours, merge 3 times extracting solution, filter, the concentrated solution that it is 0.66g/ml that filtrate decompression is concentrated into containing crude drug amount, fill, sterilizing, to obtain final product.
Functional component assay and stability study:
The mixture that comparative example is obtained and the granule being obtained by embodiment 1～3 carry out active constituent content measuring and stability study, with the useful technique effect that illustrates that the present invention is reached.
1. the active constituent content of high effective liquid chromatography for measuring sample:
(1) active constituent content measuring of the granule sample of embodiment 1～3: take 5 hydroxymethyl furfural, ferulic acid, catalpol, formononetin, Raddeanin A, ecdysterone, woodruff acid, nitidine chloride as reference substance, octadecylsilane chemically bonded silica is filler, take acetonitrile-water (0.1% phosphoric acid) as mobile phase, gradient elution, all-wave is long to be detected; Take granule 0.5g, accurately weighed, be placed in conical flask, add 50ml methanol, supersound extraction 30 minutes, taking-up lets cool, and filters, and uses methanol wash residue, and filtrate moves into 50ml volumetric flask,, shakes up to 50ml by methanol constant volume; The accurate 20 μ l need testing solution injection liquid chromatographies of drawing, measure, and to obtain final product.
(2) active constituent content measuring of comparative example mixture sample: take 5 hydroxymethyl furfural, ferulic acid, catalpol, formononetin, Raddeanin A, ecdysterone, woodruff acid, nitidine chloride as reference substance, octadecylsilane chemically bonded silica is filler, take acetonitrile-water (0.1% phosphoric acid) as mobile phase, gradient elution, all-wave is long to be detected; The accurate mixture 10ml that draws, is placed in evaporating dish, and water bath method, adds 40ml methanol, supersound extraction 30 minutes, and taking-up lets cool, and filters, and uses methanol wash residue, and filtrate moves into 50ml volumetric flask,, shakes up to 50ml by methanol constant volume; The accurate 20 μ l need testing solution injection liquid chromatographies of drawing, measure, and to obtain final product.
2. gas chromatography determination volatile component content:
(1) the granule sample of embodiment 1～3: take australene as reference substance, capillary chromatographic column, headspace sampling, 240 ℃ of injector temperatures, detector temperature is 260 ℃, carrier gas is helium; Precision takes 1.0g sample, adds water dissolution, and ultrasonic 30 minutes, water was settled to 50ml, proceeded to headspace sampling bottle after shaking up, and jumped a queue, and put into head-space sampler auto injection, mensuration, to obtain final product.
(2) comparative example mixture sample: take australene as reference substance, capillary chromatographic column, headspace sampling, 240 ℃ of injector temperatures, detector temperature is 260 ℃, carrier gas is helium; The accurate mixture 10ml that draws, water is settled to 50ml, proceeds to headspace sampling bottle after shaking up, and jumps a queue, and puts into head-space sampler auto injection, mensuration, to obtain final product.
3. sample stability research:
(1) the granule sample of embodiment 1～3: granule sample is enclosed to conventional granulates agent complex pocket, prepare 3 batches, carry out the room temperature test that keeps sample for a long time by the method for " Chinese Pharmacopoeia " appendix stability study guideline, respectively in outward appearance, the character of 0,3,6 month observation preparation.
(2) comparative example mixture sample: get 3 batches of mixture samples and carry out the room temperature test that keeps sample for a long time by the method for " Chinese Pharmacopoeia " appendix stability study guideline, outward appearance, the character of observing preparation at 0,3,6 month respectively.
4. result of study:
After measured, the active constituent content of each sample is as shown in table 1, table 2:
Table 1 high effective liquid chromatography for measuring active constituent content (μ g/g)
Table 2 gas chromatography is measured volatile component content
| Sample | Batch | Australene content (μ g/g) |
| Embodiment 1 | 5 | 1.3 |
| Embodiment 2 | 5 | 1.1 |
| Embodiment 3 | 5 | 1.2 |
| Comparative example mixture | 5 | 0.2 |
As seen from the above table, preparation of the present invention is compared with common mixture, and active constituent content is high, and drug effect is better.
In addition,, through long-term reserved sample observing, comparative example mixture sample engenders precipitation, color burn after storing; And the granule sample of the embodiment of the present invention 1～3 without occurring hardening, metachromatism, stability significantly improves.
The test of pesticide effectiveness
According to clarifying a diagnosis about the diagnostic criteria of superficial thrombophlebitis in " peripheral vascular disease Chinese and western medicine diagnostics ".Outpatient service and inpatient be totally 200 examples, wherein extremity superficial thrombophlebitis 100 examples, migration superficial thrombophlebitis 40 examples, breast stomach wall superficial thrombophlebitis 60 examples, age 20～65, male 120 examples, female's 80 examples.Be divided at random two groups.Wherein treatment group 100 examples, matched group 100 examples, between two groups, the physical data such as age, the course of disease, the state of an illness is through check no significant difference.
Therapeutic Method
Matched group: acute stage is given oral aspirin, antibiotics, nonsteroidal antiinflammatory drug, vitamin C, compound recipe bromelain sheet etc., and chronic phase is given In Rutin Compound Tablets, Radix Notoginseng total glucosides tablet etc.
Treatment group: add on the basis of matched group and take after mixing it with water with embodiment 1～3 gained Chinese medicine preparation warm water, each 5g, every day 2 times; 15d is 1 course for the treatment of, after the 5d of interval, carries out the next course for the treatment of.
Criterion of therapeutical effect: formulate with reference to " peripheral vascular disease Chinese and western medicine diagnostics ".Fully recover: local red and swollen heat pain and hard rope bar disappear, non-pigment calmness, it is normal that body temperature and leukocyte recover, nothing recurrence in 1 year; Effective: the disappearance of swelling and ache, rope bar does not absorb completely, has pigmentation, nothing recurrence in half a year; Effective: swell and ache and alleviate, have tenderness, rope bar exists, without dwindling; Invalid: above symptom and sign is without change, or outbreak repeatedly.Therapeutic outcome is in table 3.
Curative effect comparison after the each group treatment of table 3
Visible, in each course of disease group, treatment group total effective rate is up to 98%, and its curative effect is obviously better than matched group, and the course of disease is shorter, and curative effect is better.
Claims (9)
1. the vasculitic Chinese medicine composition for the treatment of, is characterized in that comprising following component: Millettia Speciosa 2 weight portions, Radix Rehmanniae Preparata 2 weight portions, Radix Angelicae Sinensis 1 weight portion, Radix Achyranthis Bidentatae 1 weight portion, Caulis Spatholobi 2 weight portions, Herba Hedyotidis Diffusae 1 weight portion, Radix Zanthoxyli 1 weight portion, Rhizoma Anemones Raddeanae 1 weight portion;
And make according to following steps:
Step 1: get Millettia Speciosa, Radix Angelicae Sinensis, after soaking, use extraction by steam distillation volatile oil, the volatile oil of acquisition is formed to volatile oil beta cyclodextrin inclusion complex with beta-cyclodextrin inclusion compound, aqueous solution after distillation filters, for subsequent use, in medicinal residues, add Rhizoma Anemones Raddeanae, Caulis Spatholobi, then add alcohol reflux, filter, filtrate recycling ethanol concentrating under reduced pressure become clear paste A for subsequent use;
Step 2: get Radix Rehmanniae Preparata, Radix Achyranthis Bidentatae, Herba Hedyotidis Diffusae, Radix Zanthoxyli, add supersound extraction after the water soaking of pH=3～4.5, extracting liquid filtering is for subsequent use to container; To the water that continues to add pH=6～8 in medicinal residues, supersound extraction, extracting liquid filtering is for subsequent use to container; Again to the water that continues to add pH=8～9 in medicinal residues, supersound extraction, extracting liquid filtering is for subsequent use to container; Merge the aqueous solution after filtrate and the distillation that obtains of step 1 of extracting for three times, concentrating under reduced pressure becomes clear paste B for subsequent use;
Step 3: the clear paste B that the clear paste A that step 1 is obtained and step 2 obtain mixes, and vacuum dehydrating at lower temperature, is ground into fine powder, adds volatile oil beta cyclodextrin inclusion complex and the proper auxiliary materials that step 1 obtains to be prepared into granule.
2. Chinese medicine composition according to claim 1, is characterized in that: in step 1, be 7:1 for soaking the water of Millettia Speciosa and Radix Angelicae Sinensis and the volume ratio of medical material.
3. Chinese medicine composition according to claim 1, is characterized in that: in step 1, be 4:1 for the beta-schardinger dextrin-of enclose and the volume ratio of volatile oil.
4. Chinese medicine composition according to claim 1, is characterized in that: in step 1, medicinal residues add Rhizoma Anemones Raddeanae, Caulis Spatholobi, adds 60% alcohol reflux 3 times of 8 times of volumes, each 2 hours at every turn.
5. Chinese medicine composition according to claim 1, is characterized in that: in step 2, when each supersound extraction, the water adding and the volume ratio of medicinal residues are 8:1.
6. Chinese medicine composition according to claim 1, is characterized in that: in step 2, when supersound extraction, add the water soaking of pH=3.5 after 0.5 hour, to carry out supersound extraction for the first time.
7. Chinese medicine composition according to claim 1, is characterized in that: in step 2, when supersound extraction, add the water of pH=7 for the second time.
8. Chinese medicine composition according to claim 1, is characterized in that: in step 2, when supersound extraction, add the water of pH=8.5 for the third time.
9. Chinese medicine composition according to claim 1, is characterized in that: in step 2, the time of each supersound extraction is 1 hour.
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| CN111214580A (en) * | 2020-03-18 | 2020-06-02 | 广州市中医医院（广州市中医中药研究所） | Chinese medicinal preparation for treating thromboangiitis obliterans by oral administration and external application, and preparation method and application thereof |
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| CN111214580A (en) * | 2020-03-18 | 2020-06-02 | 广州市中医医院（广州市中医中药研究所） | Chinese medicinal preparation for treating thromboangiitis obliterans by oral administration and external application, and preparation method and application thereof |
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