CN103028045B - Externally applied traditional Chinese medicine composition for treating acute eczema and preparation method of traditional Chinese medicine composition - Google Patents
Externally applied traditional Chinese medicine composition for treating acute eczema and preparation method of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention provides an externally applied traditional Chinese medicine composition for treating acute eczema. The traditional Chinese medicine composition comprises rhubarb, radix scutellariae, fructus kochiae, incised notopterygium, folium isatidis, rhizoma picrorhizae, herba eupatorii, catechu, fructus cnidii, seaweed, ampelopsis japonica, murraya paniculata, radix paeoniae alba, periostracum cicada, grand torreya seeds, hawthorn leaves, rhizoma bletillae, Chinese lobelia, caulis spatholobi, saffron, Chinese angelica, myrrh and rhizoma corydalis decumbentis. The composition can overcome defects such as recurrence and tolerance caused by western medicine such as glucocorticoid ointments, and has the advantages of relieving skin lesion symptoms, reducing the recurrence rate, shortening the treatment time and improving the curative effect compared with the western medicine such as the glucocorticoid ointments.
Description
Technical field
The present invention relates to Chinese medicine technical field, relate in particular to a kind of external medicine composition that is used for the treatment of acute eczema and preparation method thereof.
Background technology
Eczema is a kind of anaphylactic disease, and its reason may be relevant with allergic constitution with sensitinogen or allergy, is a kind of common diseases associated with inflammation of department of dermatologry, clinical many with erythra form, be easy to ooze out course of disease delay, easily recurrence is feature, and violent pruritus is its cardinal symptom.Caused by multiple internal and external factor, its exopathogenic factor is relevant with weather, the articles for daily use contact, diet etc., endogenous cause of ill is relevant with anxiety, fatigue, insomnia, endocrine, digestive functional disturbance, dysbolismus etc., in recent years, because air pollution, social pressure increase, the factors such as industrialization degree expands, the change of dietary structure, the sickness rate of eczema has the trend raising year by year, eczema has been an important public health problem in the world now, has a strong impact on patient's physical and mental health and quality of life.
Eczema is divided into acute eczema, subacute eczema and chronic eczema according to the course of disease, wherein, acute stage,, eczema accounted for 15% of Dermatology Outpatient Department amount, it has taking papulovesicle as master the tendency of oozing out, severe patient can general the whole body and acute pruritus can form because scratching again rotten to the corn then infection to patient body and psychology and all cause very large misery, if treatment can change subacute and chronic eczema not in time, course of disease protracted course of disease, very itches unbearably.
Doctor trained in Western medicine is thought acute eczema generally and allergy has certain relation, the treatment of acute eczema is divided into local topical and system orally taken for curing at present, orally taken for curing is mainly antihistamine drug, external used medicine is mainly glucocorticoid ointment, but such ointment Reusability easily causes hormone dependence syndrome, make on the contrary eczema repeatedly show effect, in addition, drug resistance is a very large problem of such medicine of puzzlement always.
External treatment occupies unique status in Chinese medicine treatment acute eczema, by local topical medicine, can make the efficacy of a drug sick institute that goes directly, and treats pointed and feasibility.External medicine composition can make aspect acute eczema local vascular shrink in treatment, and hyperemia alleviates, sepage reduce and reach antiinflammatory, antipruritic, suppress the object of oozing out, the disease of not only can going directly institute, by thoroughly reaching knee joint reason, happy passages through which vital energy circulates, QI and blood regulating, the righting local directly therapeutical effect of mechanism performance such as get rid of evils, can also pass through flesh Teng hair key, go deep into internal organs, play the effect of Chinese medicine, and external medicine composition is percutaneous dosing, is not subject to gastrointestinal enzyme, Digestive system, the impact of the factors such as pH value.
The present invention is exactly on the basis of theory of Chinese medical science, a kind of external medicine composition that is used for the treatment of acute eczema is proposed, it can overcome the defect such as Relapse rate, drug resistance that the Western medicine medicines such as glucocorticoid ointment bring, and alleviating, the aspects such as skin lesion symptom, reduction relapse rate, shortening treatment time, raising curative effect are with the obvious advantage with respect to Western medicine such as glucocorticoid ointment.
Summary of the invention
Technical problem to be solved by this invention is, a kind of external medicine composition that is used for the treatment of acute eczema is proposed, it can overcome the defect such as Relapse rate, drug resistance that the Western medicine medicines such as glucocorticoid ointment bring, and alleviating, the aspects such as skin lesion symptom, reduction relapse rate, shortening treatment time, raising curative effect are with the obvious advantage with respect to Western medicine such as glucocorticoid ointment.
In order to solve the problems of the technologies described above, the invention provides a kind of external medicine composition that is used for the treatment of acute eczema, its crude drug comprises: Radix Et Rhizoma Rhei, Radix Scutellariae, the Fructus Kochiae, Rhizoma Et Radix Notopterygii, Folium Isatidis, Rhizoma Picrorhizae, Herba Eupatorii, catechu, Fructus Cnidii, Sargassum, Radix Ampelopsis, Folium Et Cacumen Murrayae, the Radix Paeoniae Alba, Periostracum Cicadae, Semen Torreyae, Folium Crataegi, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Lobeliae Chinensis, Caulis Spatholobi, Stigma Croci, Radix Angelicae Sinensis, Myrrha, Rhizoma Corydalis Decumbentis.
Wherein, in described external medicine composition, the weight portion of each crude drug is respectively Radix Et Rhizoma Rhei 30 weight portion ~ 40 weight portions, Radix Scutellariae 75 weight portion ~ 85 weight portions, the Fructus Kochiae 30 weight portion ~ 40 weight portions, Rhizoma Et Radix Notopterygii 20 weight portion ~ 30 weight portions, Folium Isatidis 60 weight portion ~ 70 weight portions, Rhizoma Picrorhizae 25 weight portion ~ 35 weight portions, Herba Eupatorii 15 weight portion ~ 25 weight portions, catechu 20 weight portion ~ 30 weight portions, Fructus Cnidii 30 weight portion ~ 40 weight portions, Sargassum 20 weight portion ~ 30 weight portions, Radix Ampelopsis 25 weight portion ~ 35 weight portions, Folium Et Cacumen Murrayae 20 weight portion ~ 30 weight portions, the Radix Paeoniae Alba 75 weight portion ~ 85 weight portions, Periostracum Cicadae 15 weight portion ~ 25 weight portions, Semen Torreyae 10 weight portion ~ 20 weight portions, Folium Crataegi 25 weight portion ~ 35 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 20 weight portion ~ 30 weight portions, Herba Lobeliae Chinensis 35 weight portion ~ 45 weight portions, Caulis Spatholobi 45 weight portion ~ 55 weight portions, Stigma Croci 30 weight portion ~ 40 weight portions, Radix Angelicae Sinensis 50 weight portion ~ 60 weight portions, Myrrha 25 weight portion ~ 35 weight portions, Rhizoma Corydalis Decumbentis 20 weight portion ~ 30 weight portions.
Wherein, in described external medicine composition, the weight portion of each crude drug is respectively Radix Et Rhizoma Rhei 33 weight portion ~ 37 weight portions, Radix Scutellariae 78 weight portion ~ 82 weight portions, the Fructus Kochiae 33 weight portion ~ 37 weight portions, Rhizoma Et Radix Notopterygii 23 weight portion ~ 27 weight portions, Folium Isatidis 63 weight portion ~ 67 weight portions, Rhizoma Picrorhizae 28 weight portion ~ 32 weight portions, Herba Eupatorii 18 weight portion ~ 22 weight portions, catechu 23 weight portion ~ 27 weight portions, Fructus Cnidii 33 weight portion ~ 37 weight portions, Sargassum 23 weight portion ~ 27 weight portions, Radix Ampelopsis 28 weight portion ~ 32 weight portions, Folium Et Cacumen Murrayae 23 weight portion ~ 27 weight portions, the Radix Paeoniae Alba 78 weight portion ~ 82 weight portions, Periostracum Cicadae 18 weight portion ~ 22 weight portions, Semen Torreyae 13 weight portion ~ 17 weight portions, Folium Crataegi 28 weight portion ~ 32 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 23 weight portion ~ 27 weight portions, Herba Lobeliae Chinensis 38 weight portion ~ 42 weight portions, Caulis Spatholobi 48 weight portion ~ 52 weight portions, Stigma Croci 33 weight portion ~ 37 weight portions, Radix Angelicae Sinensis 53 weight portion ~ 57 weight portions, Myrrha 28 weight portion ~ 32 weight portions, Rhizoma Corydalis Decumbentis 23 weight portion ~ 27 weight portions.
Wherein, in described external medicine composition, the weight portion of each crude drug is respectively Radix Et Rhizoma Rhei 35 weight portions, Radix Scutellariae 80 weight portions, the Fructus Kochiae 35 weight portions, Rhizoma Et Radix Notopterygii 25 weight portions, Folium Isatidis 65 weight portions, Rhizoma Picrorhizae 30 weight portions, Herba Eupatorii 20 weight portions, catechu 25 weight portions, Fructus Cnidii 35 weight portions, Sargassum 25 weight portions, Radix Ampelopsis 30 weight portions, Folium Et Cacumen Murrayae 25 weight portions, the Radix Paeoniae Alba 80 weight portions, Periostracum Cicadae 20 weight portions, Semen Torreyae 15 weight portions, Folium Crataegi 30 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 25 weight portions, Herba Lobeliae Chinensis 40 weight portions, Caulis Spatholobi 50 weight portions, Stigma Croci 35 weight portions, Radix Angelicae Sinensis 55 weight portions, Myrrha 30 weight portions, Rhizoma Corydalis Decumbentis 25 weight portions.
Wherein, the dosage form of described external medicine composition can be washing liquid, unguentum, oil preparation, liniment, tincture, cream, gel.
The present invention also provides the preparation method of above-mentioned external medicine composition, and in the time that the dosage form of described external medicine composition is washing liquid, it is specially:
Described each crude drug component is mixed in proportion, add the distilled water with respect to 6 ~ 8 times of mixture qualities, first soak 20min ~ 40min, pour in volatile oil extractor, the way of distillation is extracted volatile oil 4 ~ 6h, obtain volatile oil, remaining water extraction liquid filters, obtain filtrate, in filtering residue, again add the distilled water with respect to 3 ~ 5 times of its quality, decoct 2h ~ 3h, the decoction liquor obtaining is filtered again, obtain filtrate, filtrate is merged, adding determining alcohol is that to account for total liquor capacity be 40% ~ 50% (V/V) for 70% ~ 80% ethanol to alcohol volume content, add the volatile oil obtaining above, stir, regulating pH value is 7.0 ~ 7.5, leave standstill precipitate with ethanol, filter, filtrate is concentrated into without alcohol taste, adding distilled water to crude drug concentration is 1g/ml ~ 2g/ml, obtain washing liquid.
The present invention also provides the preparation method of above-mentioned external medicine composition, and in the time that the dosage form of described external medicine composition is liniment, it is specially:
The first step, is mixed in proportion each crude drug component in described external medicine composition, adds normal hexane, and extraction obtains oils and fats;
Second step, crude drug mixture after oil and grease extracting is dried and removed normal hexane, add the ethanol with respect to 2 ~ 4 times of determining alcohols 70% ~ 80% of crude drug mixture quality, heating and refluxing extraction 2 ~ 3 times, each 2 ~ 4h that extracts, extracting solution merges, filters, and adds glycerol, obtain solution, the weight portion that glycerol adds is 0.5 weight portion ~ 1 weight portion with respect to 100 weight portion crude drug mixture;
The 3rd step, the oils and fats that the first step is obtained mixes with lecithin, azone, grinds altogether dissolving into powder, obtains oil solution, and the quality of the lecithin adding is 0.5 times ~ 1 times of oil quality, and the azone quality adding is 0.2 times ~ 0.4 times of oil quality;
The 4th step, the oils and fats that the 3rd step is obtained joins in the solution of second step acquisition, sealing, 40 DEG C of insulated and stirred 20min ~ 30min, obtain liniment.
Wherein, the described first step is further specially each crude drug component of described external medicine composition is mixed in proportion, and packs in extractor, adds normal hexane to just flooding, soak 40min ~ 60min, under agitation extract 40min ~ 60min, emit n-hexane extract, then re-extract once, combining extraction liquid, filter, normal hexane is reclaimed in evaporation, obtains oils and fats.
The present invention also provides the using method of washing liquid prepared by above-mentioned external medicine composition preparation method, and it is specially:
After soaking medicinal liquid according to skin lesion size with hospital gauze, soak is in the 20min ~ 30min of skin lesion place.
The present invention also provides the application of above-mentioned external medicine composition in the medicine for the preparation for the treatment of acute eczema.
Beneficial effect of the present invention:
The external medicine composition that is used for the treatment of acute eczema provided by the invention can overcome the defect such as Relapse rate, drug resistance that the Western medicine medicines such as glucocorticoid ointment bring, and alleviating, the aspects such as skin lesion symptom, reduction relapse rate, shortening treatment time, raising curative effect are with the obvious advantage with respect to Western medicine such as glucocorticoid ointment.
Detailed description of the invention
Ancient medicine recognizes that external treatment is very important to acute eczema very early, the method for surgery, and the heaviest external treatment, the external treatment medicine sick institute that can go directly, its curative effect and effect are that many internal treatments are irreplaceable, often can receive the effect of getting twice the result with half the effort.Eczema belongs to the traditional Chinese medical science " eczema of lower limb " category, and exopathogenic factor is main mainly with wind, wet, heat, and damp-heat accumulation, fills in space between skin and muscles, and contamination skin is sent out as eczema, and wind is contained and itched, and wind benefaction and number becomes, therefore acute eczema play is itched, is contaminated general, the heresy that has matter for deep that wets, moist glutinous greasy, therefore protracted inflammation, repeatedly outbreak, damp and hotly accumulate hematozemia impairment of YIN of a specified duration, cause again insufficiency of the spleen blood dry, failure of skin and muscle to be nourished so plumpness chap, touchingly do not heal, primary disease is relevant with damp, wet can intrinsic heat, send out as damp and hot card, the wet impairment of the spleen of a specified duration, heat is impairment of YIN, there is erythema in damp and hot accumulateing in skin, pustule, pruritus is more than ", excess syndrome (rheumatic fever) is the main pathogenesis of acute eczema, its machine can be summarized as rheumatism pathogenic heat contamination, eczema is many because natural endowment is not resistance to, wind, wet, pathogenic heat hinders in skin and causes, acute stage, mostly is damp and hot invasion human body and gives birth to, therefore, adopt external medicine composition detoxifying and relieving itching, promoting tissue regeneration and ulcer healing, promoting blood circulation and detumescence, be beneficial to Drug Percutaneous Absorption and enter epidermis, improve local drug concentration, make the medicine affected part of going directly, performance is efficient, quick-acting clinical effectiveness.
In addition, although acute eczema occurs in human body flesh table, have substantial connection with people's entirety, it is often associated with internal organs problem, and many internal organs problems, can occur acute eczema at body surface.In Huangdi's Internal Classics, record the treatment rule of " treatment by oral administration of medicines external treatment is arranged side by side for treating the internal disease internally, external treatment being used for the disease on the exterior of the body ", " doctor's system source and course " medium cloud: " the heaviest external treatment of card of surgery ", the doctor of Qing Dynasty Wu Shangxian was once pointed out in " Li Yue Pianwen, Rhymed Discourse for Topical Remedies ": " reason of external treatment, the i.e. reason for the treatment of by oral administration of medicines; the medicine of external treatment; that is the medicine for the treatment of by oral administration of medicines, different person's method ear, medical knowledge pharmacology earless; external treatment medication generally; all medicines of this treatment by oral administration of medicines, and wherein have pleasant place, method is for it also." external medicine composition can pass through flesh Teng hair key, gos deep into internal organs, thereby realize the treatment to internal organs problem.
Based on above-mentioned theory of Chinese medical science, external medicine composition of the present invention is taking detoxifying and relieving itching, promoting tissue regeneration and ulcer healing, promoting blood circulation and detumescence, blood enriching and dryness moistening as Therapeutic Principle, the function that it has antiinflammatory, antipyretic, antiallergic action, immunomodulating, reduction capillary permeability, improve microcirculation, short histiocyte recovers, can excite nerve and cardiovascular system, dredging the meridian QI and blood regulating, improve local nutriture and whole body function, thereby reach therapeutic purposes.
The crude drug of this external medicine composition comprises: Radix Et Rhizoma Rhei, Radix Scutellariae, the Fructus Kochiae, Rhizoma Et Radix Notopterygii, Folium Isatidis, Rhizoma Picrorhizae, Herba Eupatorii, catechu, Fructus Cnidii, Sargassum, Radix Ampelopsis, Folium Et Cacumen Murrayae, the Radix Paeoniae Alba, Periostracum Cicadae, Semen Torreyae, Folium Crataegi, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Lobeliae Chinensis, Caulis Spatholobi, Stigma Croci, Radix Angelicae Sinensis, Myrrha, Rhizoma Corydalis Decumbentis.
Preferably, described external medicine composition is only made up of above-mentioned raw materials medicine component.
Fang Zhong, Radix Et Rhizoma Rhei blood circulation promoting and blood stasis dispelling, purging fire and cooling blood, Radix Scutellariae has the effect of killing superficial microbes, also has antiallergic action, immunosuppressive action, Fructus Kochiae removing dampness and detoxicating is antipruritic, the Rhizoma Et Radix Notopterygii cold expelling that induces sweat, expelling wind and dampness, Folium Isatidis, Rhizoma Picrorhizae speckle removing removing heat from blood, removing toxic substances heat clearing away, Herba Eupatorii removing dampness by means of aromatics, the appetizing of being amusing, the hemostasis of catechu removing dampness sore, Fructus Cnidii dampness is dispeled the wind, killing parasites for relieving itching, Sargassum hard masses softening and resolving, inducing diuresis to remove edema, Radix Ampelopsis heat-clearing and toxic substances removing, expelling pus and promoting granulation, Folium Et Cacumen Murrayae promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis, the merit of Periostracum Cicadae Pi Dapi, one can strengthen the merit of dispelling wind for relieving itching, and two can remove damp and waste heat between skin, Semen Torreyae killing insect and eliminating accumulation, Folium Crataegi blood circulation promoting and blood stasis dispelling, regulate the flow of vital energy and promote blood circulation, Pseudobulbus Bletillae (Rhizoma Bletillae) astringing to arrest bleeding, detumescence and promoting granulation, Herba Lobeliae Chinensis heat-clearing and toxic substances removing, inducing diuresis to remove edema, Stigma Croci blood circulation promoting and blood stasis dispelling, removing pathogenic heat from blood and toxic substance from the body, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Caulis Spatholobi nourishing blood and promoting blood circulation, the analgesic therapy of Myrrha dissipating blood stasis, detumescence and promoting granulation, Rhizoma Corydalis Decumbentis relaxing muscles and tendons and activating QI and blood in the collateral, expelling wind and removing dampness, all medicines share, and realize detoxifying and relieving itching, promoting tissue regeneration and ulcer healing, promoting blood circulation and detumescence, effect of blood enriching and dryness moistening.
In described external medicine composition, the weight portion of each crude drug is respectively:
Radix Et Rhizoma Rhei 30 weight portion ~ 40 weight portions, Radix Scutellariae 75 weight portion ~ 85 weight portions, the Fructus Kochiae 30 weight portion ~ 40 weight portions, Rhizoma Et Radix Notopterygii 20 weight portion ~ 30 weight portions, Folium Isatidis 60 weight portion ~ 70 weight portions, Rhizoma Picrorhizae 25 weight portion ~ 35 weight portions, Herba Eupatorii 15 weight portion ~ 25 weight portions, catechu 20 weight portion ~ 30 weight portions, Fructus Cnidii 30 weight portion ~ 40 weight portions, Sargassum 20 weight portion ~ 30 weight portions, Radix Ampelopsis 25 weight portion ~ 35 weight portions, Folium Et Cacumen Murrayae 20 weight portion ~ 30 weight portions, the Radix Paeoniae Alba 75 weight portion ~ 85 weight portions, Periostracum Cicadae 15 weight portion ~ 25 weight portions, Semen Torreyae 10 weight portion ~ 20 weight portions, Folium Crataegi 25 weight portion ~ 35 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 20 weight portion ~ 30 weight portions, Herba Lobeliae Chinensis 35 weight portion ~ 45 weight portions, Caulis Spatholobi 45 weight portion ~ 55 weight portions, Stigma Croci 30 weight portion ~ 40 weight portions, Radix Angelicae Sinensis 50 weight portion ~ 60 weight portions, Myrrha 25 weight portion ~ 35 weight portions, Rhizoma Corydalis Decumbentis 20 weight portion ~ 30 weight portions.
In described external medicine composition, the weight portion of each crude drug is further preferably respectively:
Radix Et Rhizoma Rhei 33 weight portion ~ 37 weight portions, Radix Scutellariae 78 weight portion ~ 82 weight portions, the Fructus Kochiae 33 weight portion ~ 37 weight portions, Rhizoma Et Radix Notopterygii 23 weight portion ~ 27 weight portions, Folium Isatidis 63 weight portion ~ 67 weight portions, Rhizoma Picrorhizae 28 weight portion ~ 32 weight portions, Herba Eupatorii 18 weight portion ~ 22 weight portions, catechu 23 weight portion ~ 27 weight portions, Fructus Cnidii 33 weight portion ~ 37 weight portions, Sargassum 23 weight portion ~ 27 weight portions, Radix Ampelopsis 28 weight portion ~ 32 weight portions, Folium Et Cacumen Murrayae 23 weight portion ~ 27 weight portions, the Radix Paeoniae Alba 78 weight portion ~ 82 weight portions, Periostracum Cicadae 18 weight portion ~ 22 weight portions, Semen Torreyae 13 weight portion ~ 17 weight portions, Folium Crataegi 28 weight portion ~ 32 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 23 weight portion ~ 27 weight portions, Herba Lobeliae Chinensis 38 weight portion ~ 42 weight portions, Caulis Spatholobi 48 weight portion ~ 52 weight portions, Stigma Croci 33 weight portion ~ 37 weight portions, Radix Angelicae Sinensis 53 weight portion ~ 57 weight portions, Myrrha 28 weight portion ~ 32 weight portions, Rhizoma Corydalis Decumbentis 23 weight portion ~ 27 weight portions.
In described external medicine composition, the weight portion of each crude drug is most preferably respectively:
Radix Et Rhizoma Rhei 35 weight portions, Radix Scutellariae 80 weight portions, the Fructus Kochiae 35 weight portions, Rhizoma Et Radix Notopterygii 25 weight portions, Folium Isatidis 65 weight portions, Rhizoma Picrorhizae 30 weight portions, Herba Eupatorii 20 weight portions, catechu 25 weight portions, Fructus Cnidii 35 weight portions, Sargassum 25 weight portions, Radix Ampelopsis 30 weight portions, Folium Et Cacumen Murrayae 25 weight portions, the Radix Paeoniae Alba 80 weight portions, Periostracum Cicadae 20 weight portions, Semen Torreyae 15 weight portions, Folium Crataegi 30 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 25 weight portions, Herba Lobeliae Chinensis 40 weight portions, Caulis Spatholobi 50 weight portions, Stigma Croci 35 weight portions, Radix Angelicae Sinensis 55 weight portions, Myrrha 30 weight portions, Rhizoma Corydalis Decumbentis 25 weight portions.
The pharmacology of each crude drug is as follows:
Radix Et Rhizoma Rhei: latin name Rhei Radix etRhizoma, bitter in the mouth, cold in nature, return stomach warp; Large intestine channel; Liver Channel; Spleen channel, have attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Effect of removing toxic substances, cures mainly excess-heat constipation; The accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhea; Edema abdominal distention; Dysuria; Conjunctival congestion; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Gastropyretic vomiting; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Blood-retention; Amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Lump in the abdomen; Traumatic injury; Pyretic toxicity carbuncle and ulcer; Erysipelas; The cards such as scald.
Radix Scutellariae: latin name Scutellariae Radix, bitter in the mouth, cold in nature, enters the heart, lung, stomach, gallbladder, large intestine channel, has heat clearing and damp drying, and eliminating fire and detoxication is antiabortive, and the effect of hemostasis is mainly used in diarrhoea, dysentery, jaundice, pyretic stranguria due to damp and hot; Cough due to lung-heat, thirsty pharyngalgia, also can be used for excessive fetal movement due to heat in pregnancy, and pyretic toxicity pathogenic fire is invaded the swollen card of carbuncle sore poison of excessive skin.
The Fructus Kochiae: latin name KochiaeFructus, cold in nature, acrid in the mouth, hardship, have clearing away heat-damp and promoting diuresis, and effect of dispelling wind for relieving itching cures mainly the cards such as difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.
Rhizoma Et Radix Notopterygii: latin name NotopterygiiRhizoma etRadix, acrid in the mouth, hardship, warm in nature, enter kidney, urinary bladder channel, there is effect of the cold expelling that induces sweat, expelling wind and dampness, pain relieving, there is the wet exterior syndrome of wind and cold folder, disease is seen fever with aversion to cold, headache as is wrapped up in, neck rigid back pain, and limbs are heavy, the cards such as joint is ached, anemofrigid-damp arthralgia.
Folium Isatidis: latin name IsatidsFolium, bitter in the mouth, property Great Cold, GUIXIN, liver, gallbladder, stomach warp, have antipyretic and detoxicated, cooling blood and dissolving purpura, effect of jaundice eliminating, the excess-heat can clearing heat in QI system dividing, can separate again the pyretic toxicity of blood system, the high febrile perspiration being mainly used in due to pestilence calentura goes out, excessive thirst taking fluids profusely; The speckle that fire-toxin is flourishing is gone mad, the symptoms such as haematemesis; The unconsciousness due to high fever of measles, rash color is purple dark; Dampness-heat in the liver and gallbladder is accumulate the jaundice of steaming; The deafness and tinnitus of liver and gall fire liter; The cards such as pharyngalgia due to fire stagnation pyretic toxicity, aphtha of the mouth and tongue, hepatitis.
Rhizoma Picrorhizae: latin name Picrorhizae Rhizoma, bitter in the mouth, cold in nature, return liver, stomach, large intestine channel, there is reducing the asthenic fever, dispelling fever with infantile malnutrition, effect of clearing away damp-heat, cures mainly osteopyrexia and fever, children's's infantile malnutrition with fever, damp-heat dysentery, jaundice dark coloured urine, the cards such as swelling and pain of hemorrhoid.
Herba Eupatorii: acrid in the mouth, property is flat, returns spleen, stomach, lung meridian, has expelling summer-heat and damp, ward off dirty and in effect, cure mainly heat-damp in summer, cold and heat headache, accumulates in moistening, gastral cavity painful abdominal mass is not hungry, nausea and vomiting is sweet greasy in mouthful, disappears and truly waits card.
Catechu: bitter in the mouth, puckery, cold nature, returns lung meridian, has effect of removing dampness promoting tissue regeneration and ulcer healing, for ulcer being unable to heal, eczema, aphtha, falls cards such as flutterring the pain of injury, traumatic hemorrhage.
Fructus Cnidii: latin name Cnidi Fructus, acrid in the mouth, hardship, warm in nature, enter kidney channel, there is the effect of warming the kidney to invigorate YANG, removing dampness and killing parasites, dispelling wind for relieving itching, the impotence in male, the woman's cold womb that cause for kidney yang deficiency are infertile, the cards such as cold-damp leukorrhagia or chills and pain of the waist and kness.
Sargassum: bitter in the mouth, salty, cold in nature, return liver, stomach, kidney channel, there is eliminating phlegm and softening indurated mass eliminating stagnation, effect of inducing diuresis to remove edema, cures mainly thyromegaly, a submental lymph nodes tuberculosis.Eliminating stagnation gas carbuncle, abdomen inner product piece, distending pain, the ring of abdomen hollow.Also can descend 12 kinds of edema, treat between skin and gather sudden and violent bursting, stay depressed heat, diuresis.
Radix Ampelopsis: latin name Ampelopsis Radix, bitter in the mouth, cold nature, GUIXIN, stomach warp, have effect of heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, expelling pus and promoting granulation, cures mainly the cards such as carbuncle carbuncle on the back, furuncle, burn and scald.
Folium Et Cacumen Murrayae: latin name Murrayae Folium etCacumen, acrid in the mouth, micro-hardship, warm in nature, slightly poisonous, there is effect of promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis, for stomachache, rheumatic arthralgia, treating swelling and pain by traumatic injury, fracture, sore and toxic, venom, the cards such as eczema
The Radix Paeoniae Alba: latin name Paeoniae RadixAlba, bitter in the mouth, acid, cool in nature; enter liver, spleen channel, there is nourishing blood to suppress the hyperactive liver, slow middle pain relieving; yin fluid astringing is received effect of antiperspirant, cures mainly the breast abdomen pain over the hypochondriac region, dysentery stomachache; spontaneous sweating; fever due to yin deficiency, menoxenia, metrorrhagia; be with inferior card, the Radix Paeoniae Alba has good liver-protective effect.
Periostracum Cicadae: latin name Cicadae Periostracum, sweet in the mouth, lung, the Liver Channel of returning cold in nature, there is a surname's wind heat extraction, rash, sore-throat relieving, effect of spasmolytic, cure mainly affection due to external wind and heat or epidemic febrile disease from the beginning of due to heating, cough, pharyngalgia, pharynx mute, measles is thoroughly sent out not smooth, rubella pruritus, wind-heat of liver channel, the cards such as the many tears of conjunctival congestion.
Semen Torreyae: latin name Torreyae Semen, sweet in the mouth, property is flat, returns lung, stomach, large intestine channel, has killing insect and eliminating accumulation, nourishing the lung to arrest cough, effect of loosening bowel to relieve constipation, cures mainly ancylostomiasis, ascariasis, abdominal pain due to worm stagnation, infantile malnutrition, soap cough, the cards such as constipation.
Folium Crataegi: latin name Crataegi Folium, sour in the mouth, property is flat, returns Liver Channel, has blood circulation promoting and blood stasis dispelling, regulates the flow of vital energy and promotes blood circulation, and changes effect of turbid blood fat reducing, cures mainly qi depression to blood stasis, obstruction of qi in the chest and cardialgia, chest distress, palpitation and amnesia, vertigo and tinnitus, the cards such as hyperlipidemia.
Pseudobulbus Bletillae (Rhizoma Bletillae): latin name BletillacRhizoma, bitter in the mouth, sweet, puckery, cold nature, returns lung, liver, stomach warp; there is tonifying the lung hemostasis, detumescence and promoting granulation, effect of sore, cures mainly lung and hinders hemoptysis; epistaxis, incised wound is hemorrhage, swollen ulcer drug; ulcer pain, soup fire is burnt, the cards such as rhagadia manus et pedis; Pseudobulbus Bletillae (Rhizoma Bletillae) includes Rhizoma Bletillae gel, can make leukocyte recruitment, forms artificial thrombosis; reach the effect of rapid hemostasis, the phlegmatic temperament that Pseudobulbus Bletillae (Rhizoma Bletillae) contains, can cover formation thin film at wound surface and reach hemorrhage of protection and stop blooding.
Herba Lobeliae Chinensis: latin name LobeliaeChinensis Herba, acrid in the mouth, property is flat, and GUIXIN, small intestinal, lung meridian have effect of heat-clearing and toxic substances removing, inducing diuresis to remove edema, cure mainly the cards such as snake bite and insect sting, jaundice due to damp-heat, eczema eczema, carbuncle furuncle.
Caulis Spatholobi: latin name SpatholobiCaulis, bitter in the mouth, sweet, warm in nature, enter liver, kidney channel, there is blood vessel dilating, enrich blood and invigorate blood circulation, regulating menstruation, effect of relaxing muscles and tendons and activating QI and blood in the collateral, platelet aggregation is had to obvious inhibitory action, promote animal kidney and the total phosphorus metabolism in uterus, being mainly used in treating blood deficiency has the menoxenia of silt, limbs pain is meciless, the cards such as soreness of the waist and knees, pain.
Stigma Croci: latin name CrociStigma, sweet in the mouth, property is flat, energy blood circulation promoting and blood stasis dispelling, dispersing stagnation and relieving accumulation of pathogens, pain relieving.Be used for the treatment of troubled thoughts pent-up, chest and diaphragm painful abdominal mass is vexed, spits blood, and typhoid fever is gone mad, frightened fear in a trance, women's amenorrhea, and stasis menoxenia, prolonged lochia, blood stasis is had a pain, measles, the cards such as traumatic injury.
Radix Angelicae Sinensis: latin name AngelicaeSinensis Radix, sweet in the mouth, pungent, warm in nature, enter liver, the heart, spleen channel, having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation, cures mainly having a dizzy spell of deficiency of heart-blood, fatigue and weakness, shortness of breath and palpitation, sea of blood inanition, the menoxenia of the cold and deficiency of CHONG and REN meridians or congestion retardance, dysmenorrhoea, produces or stomachache, and other blood stasis are had a pain and the card such as the constipation of deficiency of YIN insufficiency of blood dryness of the intestine, its can improve uterus blood circulation, alleviate pelvic congestion, relieving dysmenorrhea.
Myrrha: latin name Myrrha, bitter in the mouth, pungent, property is flat, enters liver, spleen, the heart, kidney channel, has effect of promoting blood circulation and stopping pain, detumescence and promoting granulation, cures mainly the cards such as breast abdomen stasis of blood pain, dysmenorrhea, amenorrhea, lump in the abdomen, traumatic injury, carbuncle skin infection, acute appendicitis, conjunctival congestion and swelling pain.
Rhizoma Corydalis Decumbentis: latin name CorydalisDecumbentisRhizoma, bitter in the mouth, micro-pungent, warm in nature, returns Liver Channel, has promoting blood circulation to remove obstruction in the collateral, and effect of promoting the circulation of QI to relieve pain, cures mainly apoplectic hemiplegia, injury from falling down, rheumatic arthritis, the cards such as sciatica.
The dosage form of described external medicine composition can be washing liquid, unguentum, oil preparation, liniment, tincture, cream, gel, and acute eczema sepage is more, conventionally adopt washing liquid, liniment, can make local vascular shrink, hyperemia alleviates, sepage reduce and reach antiinflammatory, antipruritic, suppress the object of oozing out.
In the time that the dosage form of described external medicine composition is washing liquid, its preparation method is specially:
Described each crude drug component is mixed in proportion, add the distilled water with respect to 6 ~ 8 times of mixture qualities, first soak 20min ~ 40min, pour in volatile oil extractor, the way of distillation is extracted volatile oil 4 ~ 6h, obtain volatile oil, remaining water extraction liquid filters, obtain filtrate, in filtering residue, again add the distilled water with respect to 3 ~ 5 times of its quality, decoct 2h ~ 3h, the decoction liquor obtaining is filtered again, obtain filtrate, filtrate is merged, adding determining alcohol is that to account for total liquor capacity be 40% ~ 50% (V/V) for 70% ~ 80% ethanol to alcohol volume content, add the volatile oil obtaining above, stir, regulating pH value is 7.0 ~ 7.5, leave standstill precipitate with ethanol, filter, filtrate is concentrated into without alcohol taste, adding distilled water to crude drug concentration is 1g/ml ~ 2g/ml, obtain washing liquid.
The present invention also provides the using method of above-mentioned washing liquid, is specially:
After soaking medicinal liquid according to skin lesion size with hospital gauze, soak is in the 20min ~ 30min of skin lesion place.
In the time that the dosage form of described external medicine composition is liniment, its preparation method is specially:
The first step, described crude drug component is mixed in proportion, packs in extractor, add normal hexane to just flooding, soak 40min ~ 60min, under agitation extract 40min ~ 60min, emit n-hexane extract, then re-extract once, combining extraction liquid, filter, normal hexane is reclaimed in evaporation, obtains oils and fats;
Second step, crude drug mixture after oil and grease extracting is dried and removed normal hexane, add the ethanol with respect to 2 ~ 4 times of determining alcohols 70% ~ 80% of crude drug mixture quality, heating and refluxing extraction 2 ~ 3 times, each 2 ~ 4h that extracts, extracting solution merges, filters, and adds glycerol, obtain solution, the weight portion that glycerol adds is 0.5 weight portion ~ 1 weight portion with respect to 100 weight portion crude drug mixture;
The 3rd step, the oils and fats that the first step is obtained mixes with lecithin, azone, grinds altogether dissolving into powder, obtains oil solution, and the quality of the lecithin adding is 0.5 times ~ 1 times of oil quality, and the azone quality adding is 0.2 times ~ 0.4 times of oil quality;
The 4th step, the oil solution that the 3rd step is obtained joins in the solution of second step acquisition, sealing, 40 DEG C of insulated and stirred 20min ~ 30min, obtain liniment.
The present invention also provides the application of above-mentioned external medicine composition in the medicine for the preparation for the treatment of acute eczema.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
The concrete preparation of embodiment 1 washing liquid 1
By Radix Et Rhizoma Rhei 35g, Radix Scutellariae 80g, Fructus Kochiae 35g, Rhizoma Et Radix Notopterygii 25g, Folium Isatidis 65g, Rhizoma Picrorhizae 30g, Herba Eupatorii 20g, catechu 25g, Fructus Cnidii 35g, Sargassum 25g, Radix Ampelopsis 30g, Folium Et Cacumen Murrayae 25g, Radix Paeoniae Alba 80g, Periostracum Cicadae 20g, Semen Torreyae 15g, Folium Crataegi 30g, Pseudobulbus Bletillae (Rhizoma Bletillae) 25g, Herba Lobeliae Chinensis 40g, Caulis Spatholobi 50g, Stigma Croci 35g, Radix Angelicae Sinensis 55g, Myrrha 30g, Rhizoma Corydalis Decumbentis 25g mixes, and adds the distilled water of 6kg, first soaks 40min, pour in volatile oil extractor, the way of distillation is extracted volatile oil 6h, obtains volatile oil, remaining water extraction liquid filters, obtain filtrate, in filtering residue, again add the distilled water of 2kg, decoct 3h, the decoction liquor obtaining is filtered again, obtain filtrate, filtrate is merged, adding determining alcohol is that to account for total liquor capacity be 50% (V/V) for 80% ethanol to alcohol volume content, add the volatile oil obtaining above, stir, regulating pH value is 7.0, leaves standstill precipitate with ethanol, filter, filtrate is concentrated into without alcohol taste, and adding distilled water to crude drug concentration is 1g/ml, obtains washing liquid 1.
The concrete preparation of embodiment 2 washing liquids 2
By Radix Et Rhizoma Rhei 33g, Radix Scutellariae 78g, Fructus Kochiae 33g, Rhizoma Et Radix Notopterygii 23g, Folium Isatidis 63g, Rhizoma Picrorhizae 28g, Herba Eupatorii 18g, catechu 23g, Fructus Cnidii 33g, Sargassum 23g, Radix Ampelopsis 28g, Folium Et Cacumen Murrayae 23g, Radix Paeoniae Alba 78g, Periostracum Cicadae 18g, Semen Torreyae 13g, Folium Crataegi 28g, Pseudobulbus Bletillae (Rhizoma Bletillae) 23g, Herba Lobeliae Chinensis 38g, Caulis Spatholobi 48g, Stigma Croci 33g, Radix Angelicae Sinensis 53g, Myrrha 28g, Rhizoma Corydalis Decumbentis 23g mixes, and adds the distilled water of 6kg, first soaks 40min, pour in volatile oil extractor, the way of distillation is extracted volatile oil 6h, obtains volatile oil, remaining water extraction liquid filters, obtain filtrate, in filtering residue, again add the distilled water of 2kg, decoct 3h, the decoction liquor obtaining is filtered again, obtain filtrate, filtrate is merged, adding determining alcohol is that to account for total liquor capacity be 50% (V/V) for 80% ethanol to alcohol volume content, add the volatile oil obtaining above, stir, regulating pH value is 7.0, leaves standstill precipitate with ethanol, filter, filtrate is concentrated into without alcohol taste, and adding distilled water to crude drug concentration is 1g/ml, obtains washing liquid 2.
The concrete preparation of embodiment 3 washing liquids 3
By Radix Et Rhizoma Rhei 37g, Radix Scutellariae 82g, Fructus Kochiae 37g, Rhizoma Et Radix Notopterygii 27g, Folium Isatidis 67g, Rhizoma Picrorhizae 32g, Herba Eupatorii 22g, catechu 27g, Fructus Cnidii 37g, Sargassum 27g, Radix Ampelopsis 32g, Folium Et Cacumen Murrayae 27g, Radix Paeoniae Alba 82g, Periostracum Cicadae 22g, Semen Torreyae 17g, Folium Crataegi 32g, Pseudobulbus Bletillae (Rhizoma Bletillae) 27g, Herba Lobeliae Chinensis 42g, Caulis Spatholobi 52g, Stigma Croci 37g, Radix Angelicae Sinensis 57g, Myrrha 32g, Rhizoma Corydalis Decumbentis 27g mixes, and adds the distilled water of 6kg, first soaks 40min, pour in volatile oil extractor, the way of distillation is extracted volatile oil 6h, obtains volatile oil, remaining water extraction liquid filters, obtain filtrate, in filtering residue, again add the distilled water of 2kg, decoct 3h, the decoction liquor obtaining is filtered again, obtain filtrate, filtrate is merged, adding determining alcohol is that to account for total liquor capacity be 50% (V/V) for 80% ethanol to alcohol volume content, add the volatile oil obtaining above, stir, regulating pH value is 7.0, leaves standstill precipitate with ethanol, filter, filtrate is concentrated into without alcohol taste, and adding distilled water to crude drug concentration is 1g/ml, obtains washing liquid 3.
The concrete preparation of embodiment 4 liniments 1
By Radix Et Rhizoma Rhei 35g, Radix Scutellariae 80g, Fructus Kochiae 35g, Rhizoma Et Radix Notopterygii 25g, Folium Isatidis 65g, Rhizoma Picrorhizae 30g, Herba Eupatorii 20g, catechu 25g, Fructus Cnidii 35g, Sargassum 25g, Radix Ampelopsis 30g, Folium Et Cacumen Murrayae 25g, Radix Paeoniae Alba 80g, Periostracum Cicadae 20g, Semen Torreyae 15g, Folium Crataegi 30g, Pseudobulbus Bletillae (Rhizoma Bletillae) 25g, Herba Lobeliae Chinensis 40g, Caulis Spatholobi 50g, Stigma Croci 35g, Radix Angelicae Sinensis 55g, Myrrha 30g, Rhizoma Corydalis Decumbentis 25g mixes, and packs in extractor, adds normal hexane to just flooding, soak 60min, under agitation extract 60min, emit n-hexane extract, once, combining extraction liquid, filters re-extract again, normal hexane is reclaimed in evaporation, obtains oils and fats, and the crude drug mixture after oil and grease extracting is dried and removed normal hexane, add the ethanol of 2.5kg determining alcohol 80%, heating and refluxing extraction 3 times is extracted 4h at every turn, and extracting solution merges, filter, add 5g glycerol, obtain solution, by the oils and fats obtaining above with respect to the lecithin of 0.5 times of its quality, the azone of 0.3 times mixes, and grinds altogether dissolving into powder, obtains oil solution, oil solution is joined in the solution obtaining above, and sealing, 40 DEG C of insulated and stirred 30min, obtain liniment.
Embodiment 5 acute toxicity testings
50 of Cavia porcelluss (being provided by Qingdao City's laboratory animal and zoopery center) are provided, male and female half and half, body weight is 250g ~ 300g, be divided into 5 groups, every group 10, wherein 1 group of Cavia porcellus is blank group, smear respectively washing liquid 1 prepared by 0.70ml/kg embodiment 1 to embodiment 3 to washing liquid 3 (smearing method of washing liquid is: after soaking medicinal liquid according to skin lesion size hospital gauze, soak is in the 30min of skin lesion place) for other four groups, smear liniment 1 prepared by 0.70ml/kg embodiment 4, 24h before administration, by spinal column both sides, back unhairing (losing hair or feathers with 10% sodium sulfide after first cropping), scope is slightly larger than 6 × 6cm.After unhairing, 24h checks that whether skin of unhairing is injured, injured skin should not be made the toxicity test of intact skin, the making of damaged skin adopts coarse sandpaper that unhairing is sterilized to skin abrasion taking Seepage blood as degree, then smear washing liquid and liniment at unhairing place, after 24h, start to observe general reaction situation, continuously 7d.Record the body weight of animal, skin and hair, the variation of eye and mucosa, the observation of poisoning manifestations is identical with the acute toxicity testing of whole body administration.To there being the animal of death, dissect in time, there is macroscopic pathological changes to carry out histopathologic examination, result shows, in 7d, the animal mental status, activity, breathing, diet, feces and body weight gain are all normal, without performances such as secretions increases, without animal dead, observation period finishes to put to death spoil perusal, and administration group group and matched group Cavia porcellus are showed no internal organs ANOMALOUS VARIATIONS.
Embodiment 6 long term toxicity tests
50 of Cavia porcelluss (being provided by Qingdao City's laboratory animal and zoopery center) are provided, male and female half and half, body weight is 250g ~ 300g, be divided into 5 groups, every group 10, wherein smear intact skin for two groups, smear respectively washing liquid 1 (smearing method as described in Example 5) and liniment 1, the applying amount of washing liquid is 0.70ml/kg, the applying amount of powder is 0.70ml/kg, smear damaged skin for two groups, smear respectively washing liquid 1 and liniment 1, the applying amount of washing liquid is 0.70ml/kg, the applying amount of liniment is 0.70g/kg, remaining one group is matched group, Cavia porcellus is spinal column both sides, 24h back unhairing before administration, area is slightly larger than 6cm × 6cm.The making of damaged skin adopts coarse sandpaper scratch ， taking Seepage blood as degree, and then, by group administration, be administered once every day, contacts skin 6h at every turn, successive administration 30d.Observe every day such as administration local skin and animal behavior activity, the mental status, food-intake, feces character etc.Within every 3 days, weigh once, and adjust dosage by body weight.24h after last administration, puts to death 6 animals for every group and carries out hematology, blood biochemical and the inspection of pathology indices.Remaining animal does drug withdrawal and recovers to observe after 15d, all puts to death, and detects indices.Result demonstration, there is not abnormal change in above every observation index, or animal dead.Perusal: splanchnocoel is without oozing of blood, organ administration group and the matched group comparisons such as the heart, liver, kidney, the aspects such as its color and luster, size, form are all without significant difference.Histological observation: it is normal that the heart, liver, nephridial tissue structure are respectively organized in administration, do not find obvious pathological change with matched group.
Embodiment 7 Experiments of Zoology
Animal
280 of kunming mices (being provided by Qingdao City's laboratory animal and zoopery center), female half and half, body weight 18～22g, be divided into immediately 14 groups, every group 20, wherein 7 groups are used for observing the impact of xylol induced mice auricle edema, be respectively blank group, model control group, positive controls, treatment group 1 to treatment group 4,7 groups are used for observing the impact of mice delayed hypersensitivity, are respectively blank group, model control group, positive controls, treatment group 5 to treatment group 8.
Reagent
Dimethylbenzene: Qingdao He Bang Chemical Co., Ltd. provides; Dinitrochlorobenzene (DNCB): Qingdao He Bang Chemical Co., Ltd. provides; Acetone: Qingdao He Bang Chemical Co., Ltd. provides; When experiment, acetone is mixed with to 1% and 5% DNFB (DNCB) acetone soln; Histamine phosphate: Jin Sui bio tech ltd, Shanghai provides; CGRP test kit: Beijing Fu Rui bio-engineering corporation.
Medicine
Treatment group 1 mice is smeared washing liquid 1 prepared by the embodiment of the present invention 1, treatment group 2 mices are smeared washing liquid 2 prepared by the embodiment of the present invention 2, treatment group 3 mices are smeared washing liquid 3 prepared by the embodiment of the present invention 3, applying amount is 0.05ml/, treatment group 4 is smeared liniment 1 prepared by the embodiment of the present invention 4, applying amount is 0.05ml/, the smearing method of washing liquid as described in Example 5, positive controls fluocinonide ointment, applying amount is 0.05ml/, and model control group and blank group give isometric normal saline.
Statistical method
Measurement data adopts
represent, between group, relatively adopt χ
2inspection, all data all adopt the processing of SPSS12.0 statistical software.
Method and result
The impact of xylol induced mice auricle edema
When experiment, each treatment group and positive controls are all smeared administration in auris dextra portion, every day 1 time, continuous 7 days, washing liquid applying amount is 0.05ml/, liniment applying amount is 0.05ml/, 30min after last administration, wash away medicine with distilled water, clean with dry cotton ball, except blank group, all the other each groups are all dripped dimethylbenzene 50 μ l two sides before and after mouse right ear and are caused inflammation, after 1h, put to death mice, punch in mice left and right ears same area with card punch (8mm), and the weight of point another name both sides auricle, taking the difference of two auricle weight as swelling, calculate each group of swelling, carry out statistical procedures, the results are shown in Table 1.
The impact of the acute ear swelling of table 1 medicine xylol induced mice
| Group | n | Ear swelling degree (mg) |
| Model control group | 20 | 6.67±1.26 |
| Positive controls | 20 | 4.29±0.92 |
| Treatment group 1 | 20 | 1.08±0.39 |
| Treatment group 2 | 20 | 1.49±0.29 |
| Treatment group 3 | 20 | 1.37±0.58 |
| Treatment group 4 | 20 | 1.15±0.41 |
| Blank group | 20 | 0.33±0.05 |
As can be seen from Table 1, adopt the mice ear due to Chinese medicine composition xylol of the present invention to have remarkable inhibitory action.
The impact of the mice delayed hypersensitivity on DNFB (DNCB) induction
Test the 1st day to model control group, positive controls, treatment group 5 the mouse web portion unhairing to treatment group 8, the about 2cm × 2cm of scope, and evenly smear abdominal part sensitized mice with 5%DNCB solution 0.1ml.Strengthening in the 2nd day 1 time.After sensitization 7 days, then excite modeling success with 1%DNCB acetone soln 0.1ml.
After exciting, each group of medicinal liquid is coated with to each mouse right ear, after 24h, put to death mice, blank group and DNCB model group normal saline gavage, every day gavage, treatment group 5 mouse right ears are smeared washing liquid 1 prepared by the embodiment of the present invention 1, treatment group 6 mouse right ears are smeared washing liquid 2 prepared by the embodiment of the present invention 2, treatment group 7 mouse right ears are smeared washing liquid 3 prepared by the embodiment of the present invention 3, applying amount is 0.5ml/, treatment group 8 mouse right ears are smeared liniment 1 prepared by the embodiment of the present invention 4, applying amount is 0.5ml/, positive controls is taken fluocinonide ointment, applying amount is 0.05g/, every day 2 times, continuous 7 days.Put to death card punch (diameter 8mm) for mice and take off left and right auricle, scales/electronic balance weighing amount, taking the difference of two ear weight as swelling, (1) calculate each group of swelling, (2) plasma C GRP concentration: get blood 1ml through eyeball, inject the test tube of 10%EDTA and aprotinin, mix, 40 DEG C, 3000r/min, 10min separated plasma, by the concentration of putting the method for exempting from and measure CGRP.Carry out statistical procedures, the results are shown in Table 2 and table 3.
The anti-Delayed onset allergy of table 2 medicine (type Ⅳ allergy) effect
| Group | n | Ear swelling degree (mg) |
| Model control group | 20 | 7.03±0.91 |
| Positive controls | 20 | 4.51±0.60 |
| Treatment group 5 | 20 | 1.27±0.38 |
| Treatment group 6 | 20 | 1.63±0.73 |
| Treatment group 7 | 20 | 1.46±0.52 |
| Treatment group 8 | 20 | 1.38±0.47 |
| Blank group | 20 | 0.33±0.10 |
The impact of table 3 on plasma C GRP
| Group | n | CGRP(pg/mL) |
| Model control group | 20 | 13.91±2.03 |
| Positive controls | 20 | 26.39±1.83 |
| Treatment group 5 | 20 | 36.02±2.47 |
| Treatment group 6 | 20 | 30.63±1.59 |
| Treatment group 7 | 20 | 31.09±1.21 |
| Treatment group 8 | 20 | 34.37±1.52 |
| Blank group | 20 | 38.07±1.51 |
Can find out from table 2 and table 3, adopt Chinese medicine composition of the present invention can significantly suppress mice Delayed onset allergy.
The impact of medicine on Cavia porcellus local skin pruritus
60 of healthy guinea pigs, (being provided by Qingdao City's laboratory animal and zoopery center), male and female half and half, body weight is 250g ~ 300g, is divided at random 6 groups by body weight, 10 every group.If model control group, positive controls, treatment group 9 is to treatment group 12, model control group gives isometric normal saline, every day 1 time, continuous 7 days, shave after hair to the each group of right back instep of Cavia porcellus, smear shaving washing liquid and the powder that hair place adopts the present invention to prepare, treatment group 9 is smeared washing liquid 1 prepared by embodiment 1, treatment group 10 is smeared washing liquid 2 prepared by embodiment 2, treatment group 11 is smeared washing liquid 3 prepared by embodiment 3, treatment group 12 is smeared liniment 1 prepared by embodiment 4, the smearing method of washing liquid illustrates in embodiment 5, positive controls is smeared fluocinonide ointment, washing liquid 1 to the applying amount of washing liquid 3 is 0.05ml/, the applying amount of powder 1 and fluocinonide ointment is 0.05ml/, 1h after last administration in the 7th day, abrading right back instep with coarse sandpaper shaves hair and sentences slight oozing of blood degree of being, the about 1m of area
2after 10min, start at wound surface Chu Di 0.01% histamine phosphate's solution, 0.05ml/ only, after this comply with 0.02%, 0.03%, 0.04% every 3min ... progressive concentration is 0.05ml/ only at every turn, until occur that Cavia porcellus later adds metapedes instep, finally there is histamine phosphate's total amount that Cavia porcellus given while later licking metapedes instep, (μ is g) as itch-threshold, the itch-threshold of record relatively more each group, carries out statistical disposition, the results are shown in Table 4.
The impact of table 4 medicine on Cavia porcellus local skin pruritus
| Group | n | (μ g) for the threshold value of itching |
| Model control group | 10 | 39.60±2.49 |
| Positive controls | 10 | 81.03±3.17 |
| Treatment group 9 | 10 | 135.09±2.26 |
| Treatment group 10 | 10 | 113.78±2.03 |
| Treatment group 11 | 10 | 115.62±2.91 |
| Treatment group 12 | 10 | 129.87±3.02 |
As can be seen from Table 4, adopt Chinese medicine composition of the present invention to there is good itching-relieving action.
Embodiment 8 clinical experiments
Diagnosis basis
All cases meets the diagnostic criteria of the acute eczema in " traditional Chinese medical science disease Standardization of diagnosis and curative effect " (publication in 1994) that " skin cypridology " (People's Health Publisher publish, 2002) and State Administration of Traditional Chinese Medicine issue.
Physical data
Select the acute eczema between in March, 2010 ~ 2011 year December to suffer from 159 examples, wherein male 82 examples, female's 77 examples, 18～67 years old age, the course of disease 3～10 days, average 7 days.Be divided at random treatment group (90 example) and matched group (69 example).Treatment group and matched group patient be in sex, the age, and the course of disease, skin lesion, the aspect there was no significant differences such as symptom have comparability.Above patient's Western medicine diagnose standard and tcm diagnosis standard all meet acute eczema.Exclusion standard: 1. Pregnant and lactant women; 2. merge serious systemic disease; 3. concurrent infection; 4. couple observation drug allergy person; 5. within nearly one week, used antihistamine drug therapist; 6. in nearly 2 weeks, used corticosteroid hormone person.
Therapeutic Method
The washing liquid 1 that treatment group is used the embodiment of the present invention 1 to prepare is treated, after soaking medicinal liquid according to skin lesion size with hospital gauze, soak is in the 30min of skin lesion place, every day 3 times, matched group skin lesion is coated with PIKANG SHUANG outside place, there are erosion, the person of oozing out, 3% boric acid solution soak, every day 3 times, 1 course for the treatment of on the equal 7th, be used in conjunction 2 courses for the treatment of.
Therapeutic evaluation
By eczema area and severity index (EASI method) standards of grading to erythema, plumpness, skin lesion scope and lichenization carry out 4 grades of scoring: 0=without, 1=is slight, 2=moderate, 3=severe.Pruritus scoring: acute pruritus, affecting live and work is 3 points; Pruritus but to restrain oneself be 2 points; Slight pruritus is 1 point; It is 0 point without gargalesthesia.Symptom integral decline index (SSRI)=[integration before (the rear integration of integration-treatment before treatment)/treatment] × 100%.Recovery from illness: SSRI >=95%, pruritus disappears; Effective: SSRI=60% ~ 94%, pruritus obviously alleviates; Effective: SSRI=20% ~ 59%, pruritus alleviates; Invalid: SSRI<20%, pruritus is front or aggravation with treatment.Using recovery from illness, effective and effective percent as total effective rate.After treating 2 courses for the treatment of, carry out efficacy evaluation.
Statistical method
Measurement data adopts X ± s to represent, relatively adopts χ between group
2inspection, all data all adopt the processing of SPSS12.0 statistical software.
Result
2 groups of Clinical efficacy comparisons, the results are shown in Table 5.
The comparison of table 52 group patient clinical curative effect
| Group | n | Recovery from illness | Effective | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 90 | 32 | 20 | 23 | 15 | 83.3 |
| Matched group | 69 | 16 | 19 | 13 | 21 | 69.6 |
Before and after treatment, EASI integral contrast, the results are shown in Table 6.
EASI integral contrast before and after the treatment of table 62 group
| Group | n | Before treatment | After treatment |
| Treatment group | 90 | 8.1±1.6 | 3.7±0.5 |
| Matched group | 69 | 7.7±0.4 | 5.5±0.7 |
Can find out from table 5 and table 6, adopt the effect of external medicine composition of the present invention treatment will be significantly better than adopting treatment with western.
Cured person is followed up a case by regular visits to recurrence comparison in 6 months, in table 7.
Table 7 cured person is followed up a case by regular visits to recurrence comparison in 6 months
| Group | Recovery from illness number | Recurrence number | Relapse rate (%) |
| Treatment group | 57 | 4 | 7.02 |
| Treatment group | 32 | 5 | 15.63 |
As can be seen from Table 7, adopt patient's the relapse rate of external medicine composition of the present invention treatment much lower with respect to Western medicine group, prove that it is difficult for recurrence.
2 groups of patient's prurituss disappear, the comparison of deflorescence time, in table 8.
Table 8 patient pruritus disappears, the deflorescence time
| Group | n | Pruritus extinction time (d) | The deflorescence time (d) |
| Treatment group | 120 | 5.2±0.7 | 6.4±1.1 |
| Matched group | 110 | 7.2±1.2 | 9.5±1.6 |
Table 8 can be found out, adopts external medicine composition treatment of the present invention can shorten pruritus extinction time and deflorescence time.
All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing amendment, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only preferred embodiment of the present invention, is not the restriction of the present invention being made to other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (8)
1. an external medicine composition that is used for the treatment of acute eczema, is characterized in that: the crude drug in described Chinese medicine composition is only made up of Radix Et Rhizoma Rhei, Radix Scutellariae, the Fructus Kochiae, Rhizoma Et Radix Notopterygii, Folium Isatidis, Rhizoma Picrorhizae, Herba Eupatorii, catechu, Fructus Cnidii, Sargassum, Radix Ampelopsis, Folium Et Cacumen Murrayae, the Radix Paeoniae Alba, Periostracum Cicadae, Semen Torreyae, Folium Crataegi, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Lobeliae Chinensis, Caulis Spatholobi, Stigma Croci, Radix Angelicae Sinensis, Myrrha, Rhizoma Corydalis Decumbentis;
In described external medicine composition, the weight portion of each crude drug is respectively Radix Et Rhizoma Rhei 30 weight portion～40 weight portions, Radix Scutellariae 75 weight portion～85 weight portions, the Fructus Kochiae 30 weight portion～40 weight portions, Rhizoma Et Radix Notopterygii 20 weight portion～30 weight portions, Folium Isatidis 60 weight portion～70 weight portions, Rhizoma Picrorhizae 25 weight portion～35 weight portions, Herba Eupatorii 15 weight portion～25 weight portions, catechu 20 weight portion～30 weight portions, Fructus Cnidii 30 weight portion～40 weight portions, Sargassum 20 weight portion～30 weight portions, Radix Ampelopsis 25 weight portion～35 weight portions, Folium Et Cacumen Murrayae 20 weight portion～30 weight portions, the Radix Paeoniae Alba 75 weight portion～85 weight portions, Periostracum Cicadae 15 weight portion～25 weight portions, Semen Torreyae 10 weight portion～20 weight portions, Folium Crataegi 25 weight portion～35 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 20 weight portion～30 weight portions, Herba Lobeliae Chinensis 35 weight portion～45 weight portions, Caulis Spatholobi 45 weight portion～55 weight portions, Stigma Croci 30 weight portion～40 weight portions, Radix Angelicae Sinensis 50 weight portion～60 weight portions, Myrrha 25 weight portion～35 weight portions, Rhizoma Corydalis Decumbentis 20 weight portion～30 weight portions.
2. external medicine composition as claimed in claim 1, is characterized in that: in described external medicine composition, the weight portion of each crude drug is respectively Radix Et Rhizoma Rhei 33 weight portion～37 weight portions, Radix Scutellariae 78 weight portion～82 weight portions, the Fructus Kochiae 33 weight portion～37 weight portions, Rhizoma Et Radix Notopterygii 23 weight portion～27 weight portions, Folium Isatidis 63 weight portion～67 weight portions, Rhizoma Picrorhizae 28 weight portion～32 weight portions, Herba Eupatorii 18 weight portion～22 weight portions, catechu 23 weight portion～27 weight portions, Fructus Cnidii 33 weight portion～37 weight portions, Sargassum 23 weight portion～27 weight portions, Radix Ampelopsis 28 weight portion～32 weight portions, Folium Et Cacumen Murrayae 23 weight portion～27 weight portions, the Radix Paeoniae Alba 78 weight portion～82 weight portions, Periostracum Cicadae 18 weight portion～22 weight portions, Semen Torreyae 13 weight portion～17 weight portions, Folium Crataegi 28 weight portion～32 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 23 weight portion～27 weight portions, Herba Lobeliae Chinensis 38 weight portion～42 weight portions, Caulis Spatholobi 48 weight portion～52 weight portions, Stigma Croci 33 weight portion～37 weight portions, Radix Angelicae Sinensis 53 weight portion～57 weight portions, Myrrha 28 weight portion～32 weight portions, Rhizoma Corydalis Decumbentis 23 weight portion～27 weight portions.
3. external medicine composition as claimed in claim 1 or 2, it is characterized in that: in described external medicine composition, the weight portion of each crude drug is respectively Radix Et Rhizoma Rhei 35 weight portions, Radix Scutellariae 80 weight portions, the Fructus Kochiae 35 weight portions, Rhizoma Et Radix Notopterygii 25 weight portions, Folium Isatidis 65 weight portions, Rhizoma Picrorhizae 30 weight portions, Herba Eupatorii 20 weight portions, catechu 25 weight portions, Fructus Cnidii 35 weight portions, Sargassum 25 weight portions, Radix Ampelopsis 30 weight portions, Folium Et Cacumen Murrayae 25 weight portions, the Radix Paeoniae Alba 80 weight portions, Periostracum Cicadae 20 weight portions, Semen Torreyae 15 weight portions, Folium Crataegi 30 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 25 weight portions, Herba Lobeliae Chinensis 40 weight portions, Caulis Spatholobi 50 weight portions, Stigma Croci 35 weight portions, Radix Angelicae Sinensis 55 weight portions, Myrrha 30 weight portions, Rhizoma Corydalis Decumbentis 25 weight portions.
4. external medicine composition as claimed in claim 1 or 2, is characterized in that: the dosage form of described external medicine composition is washing liquid, unguentum, oil preparation, liniment, tincture, cream, gel.
5. the preparation method of the external medicine composition described in claim 1 or 2, is characterized in that: in the time that the dosage form of described external medicine composition is washing liquid, is specially,
Described each crude drug component is mixed in proportion, add the distilled water with respect to 6～8 times of mixture qualities, first soak 20min～40min, pour in volatile oil extractor, the way of distillation is extracted volatile oil 4～6h, obtain volatile oil, remaining water extraction liquid filters, obtain filtrate, in filtering residue, again add the distilled water with respect to 3～5 times of its quality, decoct 2h～3h, the decoction liquor obtaining is filtered again, obtain filtrate, filtrate is merged, adding determining alcohol is that to account for total liquor capacity be 40%～50% (V/V) for 70%～80% ethanol to alcohol volume content, add the volatile oil obtaining above, stir, regulating pH value is 7.0～7.5, leave standstill precipitate with ethanol, filter, filtrate is concentrated into without alcohol taste, adding distilled water to crude drug concentration is 1g/ml～2g/ml, obtain washing liquid.
6. the preparation method of the external medicine composition described in claim 1 or 2, is characterized in that: in the time that the dosage form of described external medicine composition is liniment, is specially,
The first step, is mixed in proportion each crude drug component in described external medicine composition, adds normal hexane, and extraction obtains oils and fats;
Second step, crude drug mixture after oil and grease extracting is dried and removed normal hexane, add the ethanol with respect to 2～4 times of determining alcohols 70%～80% of crude drug mixture quality, heating and refluxing extraction 2～3 times, each 2～4h that extracts, extracting solution merges, filters, and adds glycerol, obtain solution, the weight portion that glycerol adds is 0.5 weight portion～1 weight portion with respect to 100 weight portion crude drug mixture;
The 3rd step, the oils and fats that the first step is obtained mixes with lecithin, azone, grinds altogether dissolving into powder, obtains oil solution, and the quality of the lecithin adding is 0.5 times～1 times of oil quality, and the azone quality adding is 0.2 times～0.4 times of oil quality;
The 4th step, the oils and fats that the 3rd step is obtained joins in the solution of second step acquisition, sealing, 40 DEG C of insulated and stirred 20min～30min, obtain liniment.
7. the preparation method of external medicine composition claimed in claim 6, it is characterized in that: the described first step is further specially each crude drug component of described external medicine composition is mixed in proportion, and packs in extractor, add normal hexane to just flooding, soak 40min～60min, under agitation extract 40min～60min, emit n-hexane extract, then re-extract once, combining extraction liquid, filter, normal hexane is reclaimed in evaporation, obtains oils and fats.
8. the application of external medicine composition in the medicine for the preparation for the treatment of acute eczema described in claim 1 or 2.
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| CN101904998A (en) * | 2009-06-08 | 2010-12-08 | 罗兴富 | Special medicament for treating dermatophytosis and preparation method thereof |
| CN101797298A (en) * | 2010-04-22 | 2010-08-11 | 潘�清 | Ointment for treating eczema and preparation method thereof |
| CN102233085A (en) * | 2010-10-01 | 2011-11-09 | 刘叙光 | External application drug for treating skin diseases |
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