CN103028045A - Externally applied traditional Chinese medicine composition for treating acute eczema and preparation method of traditional Chinese medicine composition - Google Patents
Externally applied traditional Chinese medicine composition for treating acute eczema and preparation method of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention provides an externally applied traditional Chinese medicine composition for treating acute eczema. The traditional Chinese medicine composition comprises rhubarb, radix scutellariae, fructus kochiae, incised notopterygium, folium isatidis, rhizoma picrorhizae, herba eupatorii, catechu, fructus cnidii, seaweed, ampelopsis japonica, murraya paniculata, radix paeoniae alba, periostracum cicada, grand torreya seeds, hawthorn leaves, rhizoma bletillae, Chinese lobelia, caulis spatholobi, saffron, Chinese angelica, myrrh and rhizoma corydalis decumbentis. The composition can overcome defects such as recurrence and tolerance caused by western medicine such as glucocorticoid ointments, and has the advantages of relieving skin lesion symptoms, reducing the recurrence rate, shortening the treatment time and improving the curative effect compared with the western medicine such as the glucocorticoid ointments.
Description
Technical field
The present invention relates to the Chinese medicine technical field, relate in particular to a kind of external medicine composition that is used for the treatment of acute eczema and preparation method thereof.
Background technology
Eczema is a kind of anaphylactic disease, and its reason may be relevant with allergic constitution with sensitinogen or allergy, is a kind of common diseases associated with inflammation of department of dermatologry, clinical many with the erythra form, be easy to ooze out course of disease delay, easily recurrence is feature, and violent pruritus is its cardinal symptom.Caused by multiple internal and external factor, its exopathogenic factor is relevant with weather, the articles for daily use contact, diet etc., endogenous cause of ill is relevant with anxiety, fatigue, insomnia, endocrine, digestive functional disturbance, dysbolismus etc., in recent years, because air pollution, social pressure increase, industrialization degree enlarges, the factors such as change of dietary structure, and the sickness rate of eczema has the trend that raises year by year, eczema has been important public health problem in the world now, has a strong impact on patient's physical and mental health and quality of life.
Eczema is divided into acute eczema, subacute eczema and chronic eczema according to the course of disease, wherein, acute stage,, eczema accounted for 15% of Dermatology Outpatient Department amount, it has the tendency of oozing out take papulovesicle as the master, severe patient can general the whole body and acute pruritus can form because scratching again rotten to the corn then the infection to patient body and psychology and all cause very large misery, if untimely treatment can change subacute and chronic eczema, course of disease protracted course of disease is very itched unbearably.
Doctor trained in Western medicine is thought acute eczema generally and allergy has certain relation, the treatment of acute eczema is divided into local topical and system's orally taken for curing at present, orally taken for curing is mainly antihistamine drug, external used medicine mainly is glucocorticoid ointment, but such ointment Reusability causes the hormone dependence syndrome easily, eczema is shown effect repeatedly, and in addition, drug resistance is a very large problem of such medicine of puzzlement always.
External treatment occupies unique status in Chinese medicine treatment acute eczema, by the local topical medicine, can make the efficacy of a drug sick institute that goes directly, and treats pointed and feasibility.External medicine composition can make aspect the acute eczema local vascular shrink in treatment, and hyperemia alleviates, sepage reduce and reach antiinflammatory, antipruritic, suppress the purpose of oozing out, the disease of not only can going directly institute is by thoroughly reaching knee joint reason, happy passages through which vital energy circulates, QI and blood regulating, the righting local directly therapeutical effect of mechanism performance such as get rid of evils can also pass through flesh Teng hair key, go deep into internal organs, play the effect of Chinese medicine, and external medicine composition is percutaneous dosing, is not subjected to gastrointestinal enzyme, Digestive system, the impact of the factors such as pH value.
The present invention is exactly on the basis of theory of Chinese medical science, a kind of external medicine composition that is used for the treatment of acute eczema is proposed, it can overcome the defectives such as Relapse rate that the Western medicine medicine such as glucocorticoid ointment brings, drug resistance, alleviate the skin lesion symptom, reduce relapse rate, shorten treatment time, to improve the aspect such as curative effect with the obvious advantage with respect to Western medicine such as glucocorticoid ointment.
Summary of the invention
Technical problem to be solved by this invention is, a kind of external medicine composition that is used for the treatment of acute eczema is proposed, it can overcome the defectives such as Relapse rate that the Western medicine medicine such as glucocorticoid ointment brings, drug resistance, alleviate the skin lesion symptom, reduce relapse rate, shorten treatment time, to improve the aspect such as curative effect with the obvious advantage with respect to Western medicine such as glucocorticoid ointment.
In order to solve the problems of the technologies described above, the invention provides a kind of external medicine composition that is used for the treatment of acute eczema, its crude drug comprises: Radix Et Rhizoma Rhei, Radix Scutellariae, the Fructus Kochiae, Rhizoma Et Radix Notopterygii, Folium Isatidis, Rhizoma Picrorhizae, Herba Eupatorii, catechu, Fructus Cnidii, Sargassum, Radix Ampelopsis, Folium Et Cacumen Murrayae, the Radix Paeoniae Alba, Periostracum Cicadae, Semen Torreyae, Folium Crataegi, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Lobeliae Chinensis, Caulis Spatholobi, Stigma Croci, Radix Angelicae Sinensis, Myrrha, Rhizoma Corydalis Decumbentis.
Wherein, the weight portion of each crude drug is respectively Radix Et Rhizoma Rhei 30 weight portions ~ 40 weight portions in the described external medicine composition, Radix Scutellariae 75 weight portions ~ 85 weight portions, the Fructus Kochiae 30 weight portions ~ 40 weight portions, Rhizoma Et Radix Notopterygii 20 weight portions ~ 30 weight portions, Folium Isatidis 60 weight portions ~ 70 weight portions, Rhizoma Picrorhizae 25 weight portions ~ 35 weight portions, Herba Eupatorii 15 weight portions ~ 25 weight portions, catechu 20 weight portions ~ 30 weight portions, Fructus Cnidii 30 weight portions ~ 40 weight portions, Sargassum 20 weight portions ~ 30 weight portions, Radix Ampelopsis 25 weight portions ~ 35 weight portions, Folium Et Cacumen Murrayae 20 weight portions ~ 30 weight portions, the Radix Paeoniae Alba 75 weight portions ~ 85 weight portions, Periostracum Cicadae 15 weight portions ~ 25 weight portions, Semen Torreyae 10 weight portions ~ 20 weight portions, Folium Crataegi 25 weight portions ~ 35 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 20 weight portions ~ 30 weight portions, Herba Lobeliae Chinensis 35 weight portions ~ 45 weight portions, Caulis Spatholobi 45 weight portions ~ 55 weight portions, Stigma Croci 30 weight portions ~ 40 weight portions, Radix Angelicae Sinensis 50 weight portions ~ 60 weight portions, Myrrha 25 weight portions ~ 35 weight portions, Rhizoma Corydalis Decumbentis 20 weight portions ~ 30 weight portions.
Wherein, the weight portion of each crude drug is respectively Radix Et Rhizoma Rhei 33 weight portions ~ 37 weight portions in the described external medicine composition, Radix Scutellariae 78 weight portions ~ 82 weight portions, the Fructus Kochiae 33 weight portions ~ 37 weight portions, Rhizoma Et Radix Notopterygii 23 weight portions ~ 27 weight portions, Folium Isatidis 63 weight portions ~ 67 weight portions, Rhizoma Picrorhizae 28 weight portions ~ 32 weight portions, Herba Eupatorii 18 weight portions ~ 22 weight portions, catechu 23 weight portions ~ 27 weight portions, Fructus Cnidii 33 weight portions ~ 37 weight portions, Sargassum 23 weight portions ~ 27 weight portions, Radix Ampelopsis 28 weight portions ~ 32 weight portions, Folium Et Cacumen Murrayae 23 weight portions ~ 27 weight portions, the Radix Paeoniae Alba 78 weight portions ~ 82 weight portions, Periostracum Cicadae 18 weight portions ~ 22 weight portions, Semen Torreyae 13 weight portions ~ 17 weight portions, Folium Crataegi 28 weight portions ~ 32 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 23 weight portions ~ 27 weight portions, Herba Lobeliae Chinensis 38 weight portions ~ 42 weight portions, Caulis Spatholobi 48 weight portions ~ 52 weight portions, Stigma Croci 33 weight portions ~ 37 weight portions, Radix Angelicae Sinensis 53 weight portions ~ 57 weight portions, Myrrha 28 weight portions ~ 32 weight portions, Rhizoma Corydalis Decumbentis 23 weight portions ~ 27 weight portions.
Wherein, the weight portion of each crude drug is respectively Radix Et Rhizoma Rhei 35 weight portions in the described external medicine composition, Radix Scutellariae 80 weight portions, the Fructus Kochiae 35 weight portions, Rhizoma Et Radix Notopterygii 25 weight portions, Folium Isatidis 65 weight portions, Rhizoma Picrorhizae 30 weight portions, Herba Eupatorii 20 weight portions, catechu 25 weight portions, Fructus Cnidii 35 weight portions, Sargassum 25 weight portions, Radix Ampelopsis 30 weight portions, Folium Et Cacumen Murrayae 25 weight portions, the Radix Paeoniae Alba 80 weight portions, Periostracum Cicadae 20 weight portions, Semen Torreyae 15 weight portions, Folium Crataegi 30 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 25 weight portions, Herba Lobeliae Chinensis 40 weight portions, Caulis Spatholobi 50 weight portions, Stigma Croci 35 weight portions, Radix Angelicae Sinensis 55 weight portions, Myrrha 30 weight portions, Rhizoma Corydalis Decumbentis 25 weight portions.
Wherein, the dosage form of described external medicine composition can be washing liquid, unguentum, oil preparation, liniment, tincture, cream, gel.
The present invention also provides the preparation method of above-mentioned external medicine composition, and when the dosage form of described external medicine composition was washing liquid, it was specially:
Described each crude drug component is mixed in proportion, adding is with respect to the distilled water of 6 ~ 8 times of mixture qualities, soak first 20min ~ 40min, pour in the volatile oil extractor, the way of distillation is extracted volatile oil 4 ~ 6h, obtains volatile oil, remaining water extraction liquid filters, obtain filtrate, in filtering residue, again add the distilled water with respect to 3 ~ 5 times of its quality, decoct 2h ~ 3h, the decoction liquor that obtains is filtered again, obtain filtrate, filtrate is merged, adding determining alcohol and be 70% ~ 80% ethanol to alcohol volume content, to account for total liquor capacity be 40% ~ 50% (V/V), add the volatile oil that obtains previously, stir, regulating pH value is 7.0 ~ 7.5, leaves standstill precipitate with ethanol, filter, filtrate is concentrated into without the alcohol flavor, and adding distilled water to crude drug concentration is 1g/ml ~ 2g/ml, obtains washing liquid.
The present invention also provides the preparation method of above-mentioned external medicine composition, and when the dosage form of described external medicine composition was liniment, it was specially:
The first step is mixed in proportion each crude drug component in the described external medicine composition, adds normal hexane, and extraction obtains oils and fats;
Second step, normal hexane is removed in the oven dry of crude drug mixture behind the oil and grease extracting, adding is with respect to the ethanol of 2 ~ 4 times of determining alcohols 70% ~ 80% of crude drug mixture quality, heating and refluxing extraction 2 ~ 3 times, each 2 ~ 4h that extracts, extracting solution merges, filters, and adds glycerol, obtain solution, the weight portion that glycerol adds is 0.5 weight portion ~ 1 weight portion with respect to 100 weight portion crude drug mixture;
In the 3rd step, the oils and fats that the first step is obtained mixes with lecithin, azone, grinds altogether dissolving into powder, gets oil solution, and the quality of the lecithin that adds is 0.5 times ~ 1 times of oil quality, and the azone quality that adds is 0.2 times ~ 0.4 times of oil quality;
In the 4th step, the oils and fats that the 3rd step was obtained joins in the solution of second step acquisition, sealing, and 40 ℃ of insulated and stirred 20min ~ 30min obtain liniment.
Wherein, each crude drug component that the described first step further is specially described external medicine composition is mixed in proportion, and in the extractor of packing into, adds normal hexane to just flooding, soak 40min ~ 60min, under agitation extract 40min ~ 60min, emit n-hexane extract, re-extract once again, combining extraction liquid, filter, normal hexane is reclaimed in evaporation, obtains oils and fats.
The present invention also provides the using method of the washing liquid of above-mentioned external medicine composition preparation method preparation, and it is specially:
Soak is in the 20min ~ 30min of skin lesion place after soaking medicinal liquid according to the skin lesion size with hospital gauze.
The present invention also provide above-mentioned external medicine composition for the preparation of the treatment acute eczema medicine in application.
Beneficial effect of the present invention:
The external medicine composition that is used for the treatment of acute eczema provided by the invention can overcome the defectives such as Relapse rate that the Western medicine medicine such as glucocorticoid ointment brings, drug resistance, alleviate the skin lesion symptom, reduce relapse rate, shorten treatment time, to improve the aspect such as curative effect with the obvious advantage with respect to Western medicine such as glucocorticoid ointment.
The specific embodiment
Ancient medicine recognizes that very early external treatment is very important to acute eczema, the method for surgery, and the heaviest external treatment, the external treatment medicine sick institute that can go directly, its curative effect and effect are that many internal treatments are irreplaceable, often can receive the effect of getting twice the result with half the effort.Eczema belongs to the traditional Chinese medical science " eczema of lower limb " category, and exopathogenic factor is main mainly with wind, wet, heat, and damp-heat accumulation fills in space between skin and muscles, and the contamination skin is sent out and is that eczema, wind are contained and then itches, and wind benefaction and number becomes so the acute eczema play is itched, is contaminated general; Wet is the deep heresy that matter is arranged, moist glutinous greasy, so protracted inflammation, repeatedly outbreak; Damp and hotly accumulate hematozemia impairment of YIN of a specified duration, cause again insufficiency of the spleen blood dry, failure of skin and muscle to be nourished is not touchingly healed so plumpness is chapped, and primary disease is relevant with damp, but wet intrinsic heat, sending out is damp and hot card, the wet then impairment of the spleen of a specified duration, and heat is impairment of YIN then, erythema then appears in damp and hot accumulateing in skin, pustule, pruritus is more than ", excess syndrome (rheumatic fever) is the main pathogenesis of acute eczema; its machine can be summarized as rheumatism pathogenic heat contamination; eczema is many because natural endowment is not anti-, wind; wet; that pathogenic heat hinders in skin and causes, and acute stage then mostly is damp and hot invasion human body and gives birth to; therefore, adopt the external medicine composition detoxifying and relieving itching, promoting tissue regeneration and ulcer healing, promoting blood circulation and detumescence is beneficial to Drug Percutaneous Absorption and enters epidermis, improves local drug concentration, make the medicine affected part of going directly, performance is efficient, quick-acting clinical effectiveness.
In addition, although acute eczema occurs in human body flesh table, with people's integral body substantial connection is arranged, it often is associated with the internal organs problem, and many internal organs problems can acute eczema occur at body surface.Record the treatment rule of " the treatment by oral administration of medicines external treatment is arranged side by side for treating the internal disease internally, external treatment being used for the disease on the exterior of the body " in the Huangdi's Internal Classics, " doctor system source and course " medium cloud: " the heaviest external treatment of card of surgery ", doctor family an of Qing Dynasty Wu Shangxian was once pointed out in " Li Yue Pianwen, Rhymed Discourse for Topical Remedies ": " reason of external treatment, the i.e. reason for the treatment of by oral administration of medicines; the medicine of external treatment; that is the medicine for the treatment of by oral administration of medicines, different person's method ear, medical knowledge pharmacology earless; generally external treatment medication; medicines of this treatment by oral administration of medicines all, and pleasant place is wherein arranged, then method is for it also." external medicine composition can pass through flesh Teng hair key, gos deep into internal organs, thereby realize the treatment to the internal organs problem.
Based on above-mentioned theory of Chinese medical science, external medicine composition of the present invention is take detoxifying and relieving itching, promoting tissue regeneration and ulcer healing, promoting blood circulation and detumescence, blood enriching and dryness moistening as the Therapeutic Principle, the function that it has antiinflammatory, analgesic, antiallergic action, immunomodulating, reduction capillary permeability, improve microcirculation, short histiocyte recovers, can excite nerve and cardiovascular system, the dredging the meridian QI and blood regulating, improve local nutriture and whole body function, thereby reach therapeutic purposes.
The crude drug of this external medicine composition comprises: Radix Et Rhizoma Rhei, Radix Scutellariae, the Fructus Kochiae, Rhizoma Et Radix Notopterygii, Folium Isatidis, Rhizoma Picrorhizae, Herba Eupatorii, catechu, Fructus Cnidii, Sargassum, Radix Ampelopsis, Folium Et Cacumen Murrayae, the Radix Paeoniae Alba, Periostracum Cicadae, Semen Torreyae, Folium Crataegi, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Lobeliae Chinensis, Caulis Spatholobi, Stigma Croci, Radix Angelicae Sinensis, Myrrha, Rhizoma Corydalis Decumbentis.
Preferably, described external medicine composition only is made of above-mentioned raw materials medicine component.
In the side, the Radix Et Rhizoma Rhei blood circulation promoting and blood stasis dispelling, purging fire and cooling blood, Radix Scutellariae have the effect of killing superficial microbes, also has antiallergic action, immunosuppressive action, Fructus Kochiae removing dampness and detoxicating is antipruritic, the Rhizoma Et Radix Notopterygii cold expelling that induces sweat, expelling wind and dampness, Folium Isatidis, Rhizoma Picrorhizae speckle removing removing heat from blood, the detoxifcation heat clearing away, the Herba Eupatorii removing dampness by means of aromatics, the appetizing of being amusing, the hemostasis of catechu removing dampness sore, Fructus Cnidii dampness is dispeled the wind, killing parasites for relieving itching, Sargassum hard masses softening and resolving, inducing diuresis to remove edema, the Radix Ampelopsis heat-clearing and toxic substances removing, expelling pus and promoting granulation, the Folium Et Cacumen Murrayae promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis, the merit of Periostracum Cicadae Pi Dapi, one can strengthen the merit of dispelling wind for relieving itching, and two can remove damp and waste heat between skin, the Semen Torreyae killing insect and eliminating accumulation, the Folium Crataegi blood circulation promoting and blood stasis dispelling, regulate the flow of vital energy and promote blood circulation, the Pseudobulbus Bletillae (Rhizoma Bletillae) astringing to arrest bleeding, detumescence and promoting granulation, the Herba Lobeliae Chinensis heat-clearing and toxic substances removing, inducing diuresis to remove edema, the Stigma Croci blood circulation promoting and blood stasis dispelling, removing pathogenic heat from blood and toxic substance from the body, Radix Angelicae Sinensis, the Radix Paeoniae Alba, the Caulis Spatholobi nourishing blood and promoting blood circulation, the analgesic therapy of Myrrha dissipating blood stasis, detumescence and promoting granulation, the Rhizoma Corydalis Decumbentis relaxing muscles and tendons and activating QI and blood in the collateral, expelling wind and removing dampness, all medicines share, and realize detoxifying and relieving itching, promoting tissue regeneration and ulcer healing, promoting blood circulation and detumescence, the effect of blood enriching and dryness moistening.
The weight portion of each crude drug is respectively in the described external medicine composition:
Radix Et Rhizoma Rhei 30 weight portions ~ 40 weight portions, Radix Scutellariae 75 weight portions ~ 85 weight portions, the Fructus Kochiae 30 weight portions ~ 40 weight portions, Rhizoma Et Radix Notopterygii 20 weight portions ~ 30 weight portions, Folium Isatidis 60 weight portions ~ 70 weight portions, Rhizoma Picrorhizae 25 weight portions ~ 35 weight portions, Herba Eupatorii 15 weight portions ~ 25 weight portions, catechu 20 weight portions ~ 30 weight portions, Fructus Cnidii 30 weight portions ~ 40 weight portions, Sargassum 20 weight portions ~ 30 weight portions, Radix Ampelopsis 25 weight portions ~ 35 weight portions, Folium Et Cacumen Murrayae 20 weight portions ~ 30 weight portions, the Radix Paeoniae Alba 75 weight portions ~ 85 weight portions, Periostracum Cicadae 15 weight portions ~ 25 weight portions, Semen Torreyae 10 weight portions ~ 20 weight portions, Folium Crataegi 25 weight portions ~ 35 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 20 weight portions ~ 30 weight portions, Herba Lobeliae Chinensis 35 weight portions ~ 45 weight portions, Caulis Spatholobi 45 weight portions ~ 55 weight portions, Stigma Croci 30 weight portions ~ 40 weight portions, Radix Angelicae Sinensis 50 weight portions ~ 60 weight portions, Myrrha 25 weight portions ~ 35 weight portions, Rhizoma Corydalis Decumbentis 20 weight portions ~ 30 weight portions.
The weight portion of each crude drug further preferably is respectively in the described external medicine composition:
Radix Et Rhizoma Rhei 33 weight portions ~ 37 weight portions, Radix Scutellariae 78 weight portions ~ 82 weight portions, the Fructus Kochiae 33 weight portions ~ 37 weight portions, Rhizoma Et Radix Notopterygii 23 weight portions ~ 27 weight portions, Folium Isatidis 63 weight portions ~ 67 weight portions, Rhizoma Picrorhizae 28 weight portions ~ 32 weight portions, Herba Eupatorii 18 weight portions ~ 22 weight portions, catechu 23 weight portions ~ 27 weight portions, Fructus Cnidii 33 weight portions ~ 37 weight portions, Sargassum 23 weight portions ~ 27 weight portions, Radix Ampelopsis 28 weight portions ~ 32 weight portions, Folium Et Cacumen Murrayae 23 weight portions ~ 27 weight portions, the Radix Paeoniae Alba 78 weight portions ~ 82 weight portions, Periostracum Cicadae 18 weight portions ~ 22 weight portions, Semen Torreyae 13 weight portions ~ 17 weight portions, Folium Crataegi 28 weight portions ~ 32 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 23 weight portions ~ 27 weight portions, Herba Lobeliae Chinensis 38 weight portions ~ 42 weight portions, Caulis Spatholobi 48 weight portions ~ 52 weight portions, Stigma Croci 33 weight portions ~ 37 weight portions, Radix Angelicae Sinensis 53 weight portions ~ 57 weight portions, Myrrha 28 weight portions ~ 32 weight portions, Rhizoma Corydalis Decumbentis 23 weight portions ~ 27 weight portions.
The weight portion of each crude drug most preferably is respectively in the described external medicine composition:
Radix Et Rhizoma Rhei 35 weight portions, Radix Scutellariae 80 weight portions, the Fructus Kochiae 35 weight portions, Rhizoma Et Radix Notopterygii 25 weight portions, Folium Isatidis 65 weight portions, Rhizoma Picrorhizae 30 weight portions, Herba Eupatorii 20 weight portions, catechu 25 weight portions, Fructus Cnidii 35 weight portions, Sargassum 25 weight portions, Radix Ampelopsis 30 weight portions, Folium Et Cacumen Murrayae 25 weight portions, the Radix Paeoniae Alba 80 weight portions, Periostracum Cicadae 20 weight portions, Semen Torreyae 15 weight portions, Folium Crataegi 30 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 25 weight portions, Herba Lobeliae Chinensis 40 weight portions, Caulis Spatholobi 50 weight portions, Stigma Croci 35 weight portions, Radix Angelicae Sinensis 55 weight portions, Myrrha 30 weight portions, Rhizoma Corydalis Decumbentis 25 weight portions.
The pharmacology of each crude drug is as follows:
Radix Et Rhizoma Rhei: latin name Rhei Radix etRhizoma, bitter in the mouth, cold in nature, return the stomach warp; Large intestine channel; Liver Channel; Spleen channel, have attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; The effect of detoxifcation cures mainly the excess-heat constipation; The accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhea; The edema abdominal distention; Dysuria; Conjunctival congestion; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Gastropyretic vomiting; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Blood-retention; Amenorrhea; The stasis of blood stagnated and suffered from abdominal pain puerperal; Lump in the abdomen; Traumatic injury; Pyretic toxicity carbuncle and ulcer; Erysipelas; The cards such as scald.
Radix Scutellariae: latin name Scutellariae Radix, bitter in the mouth, cold in nature enters the heart, lung, stomach, gallbladder, large intestine channel, and heat clearing and damp drying is arranged, and eliminating fire and detoxication is antiabortive, and the effect of hemostasis is mainly used in diarrhoea, dysentery, jaundice, pyretic stranguria due to damp and hot; The cough due to lung-heat, thirsty pharyngalgia also can be used for excessive fetal movement due to heat in pregnancy, and the pyretic toxicity pathogenic fire is invaded the swollen card of carbuncle sore poison of excessive skin.
The Fructus Kochiae: latin name KochiaeFructus, cold in nature, acrid in the mouth, hardship have clearing away heat-damp and promoting diuresis, and the effect of dispelling wind for relieving itching cures mainly the cards such as difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.
Rhizoma Et Radix Notopterygii: latin name NotopterygiiRhizoma etRadix, acrid in the mouth, hardship, warm in nature, enter kidney, urinary bladder channel, have the effect of the cold expelling that induces sweat, expelling wind and dampness, pain relieving, has the wet exterior syndrome of wind and cold folder, disease is seen fever with aversion to cold, headache as is wrapped up in, neck rigid back pain, and limbs are heavy, joint is ached, the cards such as anemofrigid-damp arthralgia.
Folium Isatidis: latin name IsatidsFolium, bitter in the mouth, property Great Cold, GUIXIN, liver, gallbladder, stomach warp have antipyretic and detoxicated, cooling blood and dissolving purpura, the effect of jaundice eliminating, the excess-heat that can clearing heat in QI system divides, can separate again the pyretic toxicity of blood system, the high febrile perspiration that is mainly used in due to the pestilence calentura goes out the excessive thirst taking fluids profusely; The speckle of sending out that fire-toxin is flourishing is gone mad the symptoms such as haematemesis; The unconsciousness due to high fever of measles, the rash color is purple dark; Dampness-heat in the liver and gallbladder is accumulate the jaundice of steaming; The deafness and tinnitus of liver and gall fire liter; The cards such as the pharyngalgia due to the fire stagnation pyretic toxicity, aphtha of the mouth and tongue, hepatitis.
Rhizoma Picrorhizae: latin name Picrorhizae Rhizoma, bitter in the mouth, cold in nature, return liver, stomach, large intestine channel, have reducing the asthenic fever, dispelling fever with infantile malnutrition, the effect of clearing away damp-heat cures mainly osteopyrexia and fever, children's's infantile malnutrition with fever, damp-heat dysentery, jaundice dark coloured urine, the cards such as swelling and pain of hemorrhoid.
Herba Eupatorii: acrid in the mouth, property is flat, returns spleen, stomach, lung meridian has expelling summer-heat and damp, ward off dirty and in effect, cure mainly heat-damp in summer, the cold and heat headache is accumulate in moistening, the gastral cavity painful abdominal mass is not hungry, nausea and vomiting is sweet greasy in mouthful, disappears and truly waits card.
Catechu: bitter in the mouth, puckery, cold nature is returned lung meridian, has the effect of removing dampness promoting tissue regeneration and ulcer healing, is used for ulcer being unable to heal, eczema, aphtha is fallen cards such as pouncing on the pain of injury, traumatic hemorrhage.
Fructus Cnidii: latin name Cnidi Fructus, acrid in the mouth, hardship, warm in nature, enter kidney channel, have the effect of warming the kidney to invigorate YANG, removing dampness and killing parasites, dispelling wind for relieving itching, infertile for impotence in male, woman's cold womb that kidney yang deficiency causes, the cards such as cold-damp leukorrhagia or chills and pain of the waist and kness.
Sargassum: bitter in the mouth, salty, cold in nature, return liver, stomach, kidney channel, have the eliminating phlegm and softening indurated mass eliminating stagnation, the effect of inducing diuresis to remove edema cures mainly thyromegaly, a submental lymph nodes tuberculosis.Eliminating stagnation gas carbuncle, abdomen inner product piece, distending pain, the ring of abdomen hollow.Also can descend 12 kinds of edema, treat and gather sudden and violent bursting between skin, stay depressed heat, diuresis.
Radix Ampelopsis: latin name Ampelopsis Radix, bitter in the mouth, cold nature, GUIXIN, stomach warp have the effect of heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, expelling pus and promoting granulation, cure mainly the cards such as carbuncle carbuncle on the back, furuncle, burn and scald.
Folium Et Cacumen Murrayae: latin name Murrayae Folium etCacumen, acrid in the mouth, little hardship, warm in nature, slightly poisonous, have the effect of promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis, be used for stomachache, rheumatic arthralgia, treating swelling and pain by traumatic injury, fracture, sore and toxic, venom, the cards such as eczema
The Radix Paeoniae Alba: latin name Paeoniae RadixAlba, bitter in the mouth, acid, cool in nature; enter liver, spleen channel, have nourishing blood to suppress the hyperactive liver, slow middle pain relieving; yin fluid astringing is received the effect of antiperspirant, cures mainly the breast abdomen pain over the hypochondriac region, dysentery stomachache; spontaneous sweating; fever due to yin deficiency, menoxenia, metrorrhagia; be with inferior card, the Radix Paeoniae Alba has good liver-protective effect.
Periostracum Cicadae: latin name Cicadae Periostracum, sweet in the mouth, lung, the Liver Channel of returning cold in nature, has a surname's wind heat extraction, rash, sore-throat relieving, the effect of spasmolytic, cure mainly affection due to external wind and heat or epidemic febrile disease from the beginning of due to heating, cough, pharyngalgia, pharynx mute, measles is sent out not smooth thoroughly, the rubella pruritus, wind-heat of liver channel, the cards such as the many tears of conjunctival congestion.
Semen Torreyae: latin name Torreyae Semen, sweet in the mouth, property is flat, returns lung, stomach, large intestine channel, has killing insect and eliminating accumulation, nourishing the lung to arrest cough, the effect of loosening bowel to relieve constipation cures mainly ancylostomiasis, ascariasis, abdominal pain due to worm stagnation, infantile malnutrition, soap cough, the cards such as constipation.
Folium Crataegi: latin name Crataegi Folium, sour in the mouth, property is flat, returns Liver Channel, has blood circulation promoting and blood stasis dispelling, regulates the flow of vital energy and promotes blood circulation, and changes the effect of turbid blood fat reducing, cures mainly qi depression to blood stasis, obstruction of qi in the chest and cardialgia, chest distress, palpitation and amnesia, vertigo and tinnitus, the cards such as hyperlipidemia.
Pseudobulbus Bletillae (Rhizoma Bletillae): latin name BletillacRhizoma, bitter in the mouth, sweet, puckery, cold nature is returned lung, liver, stomach warp; have the tonifying the lung hemostasis, detumescence and promoting granulation, the effect of sore cures mainly lung and hinders hemoptysis; epistaxis, incised wound is hemorrhage, swollen ulcer drug; ulcer pain, the soup fire is burnt, the cards such as rhagadia manus et pedis; Pseudobulbus Bletillae (Rhizoma Bletillae) includes Rhizoma Bletillae gel, can make leukocyte recruitment, forms artificial thrombosis; reach the effect of rapid hemostasis, the phlegmatic temperament that Pseudobulbus Bletillae (Rhizoma Bletillae) contains can cover form thin film at wound surface and reach hemorrhage of protection and stop blooding.
Herba Lobeliae Chinensis: latin name LobeliaeChinensis Herba, acrid in the mouth, property is flat, and GUIXIN, small intestinal, lung meridian have the effect of heat-clearing and toxic substances removing, inducing diuresis to remove edema, cure mainly the cards such as snake bite and insect sting, jaundice due to damp-heat, eczema eczema, carbuncle furuncle.
Caulis Spatholobi: latin name SpatholobiCaulis, bitter in the mouth, sweet, warm in nature, enter liver, kidney channel, blood vessel dilating is arranged, enrich blood and invigorate blood circulation, regulating menstruation, the effect of relaxing muscles and tendons and activating QI and blood in the collateral, platelet aggregation there is obvious inhibitory action, promotes animal kidney and the total phosphorus metabolism in uterus, be mainly used in treating the menoxenia that blood deficiency has silt, limbs pain is meciless, the cards such as soreness of the waist and knees, pain.
Stigma Croci: latin name CrociStigma, sweet in the mouth, property is flat, energy blood circulation promoting and blood stasis dispelling, dispersing stagnation and relieving accumulation of pathogens, pain relieving.Be used for the treatment of troubled thoughts pent-up, the chest and diaphragm painful abdominal mass is vexed, spits blood, and typhoid fever is gone mad, and is frightened fear in a trance, women's amenorrhea, and the stasis menoxenia, prolonged lochia, blood stasis is had a pain, measles, the cards such as traumatic injury.
Radix Angelicae Sinensis: latin name AngelicaeSinensis Radix, sweet in the mouth, suffering, warm in nature, enter liver, the heart, spleen channel, having enriches blood invigorates blood circulation menstruction regulating and pain relieving, the effect of loosening bowel to relieve constipation cures mainly having a dizzy spell of deficiency of heart-blood, fatigue and weakness, shortness of breath and palpitation, the sea of blood is hollow, the menoxenia of the cold and deficiency of CHONG and REN meridians or congestion retardance, dysmenorrhoea is produced or stomachache, and other blood stasis are had a pain and the cards such as constipation of deficiency of YIN insufficiency of blood dryness of the intestine, its can improve the uterus blood circulation, alleviate pelvic congestion, relieving dysmenorrhea.
Myrrha: latin name Myrrha, bitter in the mouth, suffering, property is flat, enters liver, spleen, the heart, kidney channel, and the effect of promoting blood circulation and stopping pain, detumescence and promoting granulation is arranged, and cures mainly the cards such as breast abdomen stasis of blood pain, dysmenorrhea, amenorrhea, lump in the abdomen, traumatic injury, carbuncle skin infection, acute appendicitis, conjunctival congestion and swelling pain.
Rhizoma Corydalis Decumbentis: latin name CorydalisDecumbentisRhizoma, bitter in the mouth, little suffering, warm in nature, return Liver Channel, have promoting blood circulation to remove obstruction in the collateral, the effect of promoting the circulation of QI to relieve pain cures mainly apoplectic hemiplegia, injury from falling down, rheumatic arthritis, the cards such as sciatica.
The dosage form of described external medicine composition can be washing liquid, unguentum, oil preparation, liniment, tincture, cream, gel, and the acute eczema sepage is more, usually adopt washing liquid, liniment, local vascular is shunk, and hyperemia alleviates, sepage reduce and reach antiinflammatory, antipruritic, suppress the purpose of oozing out.
When the dosage form of described external medicine composition was washing liquid, its preparation method was specially:
Described each crude drug component is mixed in proportion, adding is with respect to the distilled water of 6 ~ 8 times of mixture qualities, soak first 20min ~ 40min, pour in the volatile oil extractor, the way of distillation is extracted volatile oil 4 ~ 6h, obtains volatile oil, remaining water extraction liquid filters, obtain filtrate, in filtering residue, again add the distilled water with respect to 3 ~ 5 times of its quality, decoct 2h ~ 3h, the decoction liquor that obtains is filtered again, obtain filtrate, filtrate is merged, adding determining alcohol and be 70% ~ 80% ethanol to alcohol volume content, to account for total liquor capacity be 40% ~ 50% (V/V), add the volatile oil that obtains previously, stir, regulating pH value is 7.0 ~ 7.5, leaves standstill precipitate with ethanol, filter, filtrate is concentrated into without the alcohol flavor, and adding distilled water to crude drug concentration is 1g/ml ~ 2g/ml, obtains washing liquid.
The present invention also provides the using method of above-mentioned washing liquid, is specially:
Soak is in the 20min ~ 30min of skin lesion place after soaking medicinal liquid according to the skin lesion size with hospital gauze.
When the dosage form of described external medicine composition was liniment, its preparation method was specially:
The first step, described crude drug component is mixed in proportion, in the extractor of packing into, adds normal hexane to just flooding, soak 40min ~ 60min, under agitation extract 40min ~ 60min, emit n-hexane extract, re-extract once again, combining extraction liquid, filter, normal hexane is reclaimed in evaporation, obtains oils and fats;
Second step, normal hexane is removed in the oven dry of crude drug mixture behind the oil and grease extracting, adding is with respect to the ethanol of 2 ~ 4 times of determining alcohols 70% ~ 80% of crude drug mixture quality, heating and refluxing extraction 2 ~ 3 times, each 2 ~ 4h that extracts, extracting solution merges, filters, and adds glycerol, obtain solution, the weight portion that glycerol adds is 0.5 weight portion ~ 1 weight portion with respect to 100 weight portion crude drug mixture;
In the 3rd step, the oils and fats that the first step is obtained mixes with lecithin, azone, grinds altogether dissolving into powder, gets oil solution, and the quality of the lecithin that adds is 0.5 times ~ 1 times of oil quality, and the azone quality that adds is 0.2 times ~ 0.4 times of oil quality;
In the 4th step, the oil solution that the 3rd step was obtained joins in the solution of second step acquisition, sealing, and 40 ℃ of insulated and stirred 20min ~ 30min obtain liniment.
The present invention also provide above-mentioned external medicine composition for the preparation of the treatment acute eczema medicine in application.
Below adopt embodiment to describe embodiments of the present invention in detail, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can fully understand and implements according to this.
The concrete preparation of embodiment 1 washing liquid 1
With Radix Et Rhizoma Rhei 35g, Radix Scutellariae 80g, Fructus Kochiae 35g, Rhizoma Et Radix Notopterygii 25g, Folium Isatidis 65g, Rhizoma Picrorhizae 30g, Herba Eupatorii 20g, catechu 25g, Fructus Cnidii 35g, Sargassum 25g, Radix Ampelopsis 30g, Folium Et Cacumen Murrayae 25g, Radix Paeoniae Alba 80g, Periostracum Cicadae 20g, Semen Torreyae 15g, Folium Crataegi 30g, Pseudobulbus Bletillae (Rhizoma Bletillae) 25g, Herba Lobeliae Chinensis 40g, Caulis Spatholobi 50g, Stigma Croci 35g, Radix Angelicae Sinensis 55g, Myrrha 30g, Rhizoma Corydalis Decumbentis 25g mixes, the distilled water that adds 6kg, soak first 40min, pour in the volatile oil extractor, the way of distillation is extracted volatile oil 6h, obtain volatile oil, remaining water extraction liquid filters, obtain filtrate, in filtering residue, again add the distilled water of 2kg, decoct 3h, the decoction liquor that obtains is filtered again, obtain filtrate, filtrate is merged, adding determining alcohol and be 80% ethanol to alcohol volume content, to account for total liquor capacity be 50% (V/V), add the volatile oil that obtains previously, stir, regulating pH value is 7.0, leaves standstill precipitate with ethanol, filter, filtrate is concentrated into without the alcohol flavor, and adding distilled water to crude drug concentration is 1g/ml, obtains washing liquid 1.
The concrete preparation of embodiment 2 washing liquids 2
With Radix Et Rhizoma Rhei 33g, Radix Scutellariae 78g, Fructus Kochiae 33g, Rhizoma Et Radix Notopterygii 23g, Folium Isatidis 63g, Rhizoma Picrorhizae 28g, Herba Eupatorii 18g, catechu 23g, Fructus Cnidii 33g, Sargassum 23g, Radix Ampelopsis 28g, Folium Et Cacumen Murrayae 23g, Radix Paeoniae Alba 78g, Periostracum Cicadae 18g, Semen Torreyae 13g, Folium Crataegi 28g, Pseudobulbus Bletillae (Rhizoma Bletillae) 23g, Herba Lobeliae Chinensis 38g, Caulis Spatholobi 48g, Stigma Croci 33g, Radix Angelicae Sinensis 53g, Myrrha 28g, Rhizoma Corydalis Decumbentis 23g mixes, the distilled water that adds 6kg, soak first 40min, pour in the volatile oil extractor, the way of distillation is extracted volatile oil 6h, obtain volatile oil, remaining water extraction liquid filters, obtain filtrate, in filtering residue, again add the distilled water of 2kg, decoct 3h, the decoction liquor that obtains is filtered again, obtain filtrate, filtrate is merged, adding determining alcohol and be 80% ethanol to alcohol volume content, to account for total liquor capacity be 50% (V/V), add the volatile oil that obtains previously, stir, regulating pH value is 7.0, leaves standstill precipitate with ethanol, filter, filtrate is concentrated into without the alcohol flavor, and adding distilled water to crude drug concentration is 1g/ml, obtains washing liquid 2.
The concrete preparation of embodiment 3 washing liquids 3
With Radix Et Rhizoma Rhei 37g, Radix Scutellariae 82g, Fructus Kochiae 37g, Rhizoma Et Radix Notopterygii 27g, Folium Isatidis 67g, Rhizoma Picrorhizae 32g, Herba Eupatorii 22g, catechu 27g, Fructus Cnidii 37g, Sargassum 27g, Radix Ampelopsis 32g, Folium Et Cacumen Murrayae 27g, Radix Paeoniae Alba 82g, Periostracum Cicadae 22g, Semen Torreyae 17g, Folium Crataegi 32g, Pseudobulbus Bletillae (Rhizoma Bletillae) 27g, Herba Lobeliae Chinensis 42g, Caulis Spatholobi 52g, Stigma Croci 37g, Radix Angelicae Sinensis 57g, Myrrha 32g, Rhizoma Corydalis Decumbentis 27g mixes, the distilled water that adds 6kg, soak first 40min, pour in the volatile oil extractor, the way of distillation is extracted volatile oil 6h, obtain volatile oil, remaining water extraction liquid filters, obtain filtrate, in filtering residue, again add the distilled water of 2kg, decoct 3h, the decoction liquor that obtains is filtered again, obtain filtrate, filtrate is merged, adding determining alcohol and be 80% ethanol to alcohol volume content, to account for total liquor capacity be 50% (V/V), add the volatile oil that obtains previously, stir, regulating pH value is 7.0, leaves standstill precipitate with ethanol, filter, filtrate is concentrated into without the alcohol flavor, and adding distilled water to crude drug concentration is 1g/ml, obtains washing liquid 3.
The concrete preparation of embodiment 4 liniments 1
With Radix Et Rhizoma Rhei 35g, Radix Scutellariae 80g, Fructus Kochiae 35g, Rhizoma Et Radix Notopterygii 25g, Folium Isatidis 65g, Rhizoma Picrorhizae 30g, Herba Eupatorii 20g, catechu 25g, Fructus Cnidii 35g, Sargassum 25g, Radix Ampelopsis 30g, Folium Et Cacumen Murrayae 25g, Radix Paeoniae Alba 80g, Periostracum Cicadae 20g, Semen Torreyae 15g, Folium Crataegi 30g, Pseudobulbus Bletillae (Rhizoma Bletillae) 25g, Herba Lobeliae Chinensis 40g, Caulis Spatholobi 50g, Stigma Croci 35g, Radix Angelicae Sinensis 55g, Myrrha 30g, Rhizoma Corydalis Decumbentis 25g mixes, pack in the extractor, add normal hexane to just flooding, soak 60min, under agitation extract 60min, emit n-hexane extract, re-extract once again, combining extraction liquid, filter, normal hexane is reclaimed in evaporation, obtain oils and fats, normal hexane is removed in the oven dry of crude drug mixture behind the oil and grease extracting, the ethanol that adds 2.5kg determining alcohol 80%, heating and refluxing extraction 3 times, each 4h that extracts, extracting solution merges, filter, add 5g glycerol, obtain solution, with the oils and fats that obtains previously and lecithin with respect to 0.5 times of its quality, 0.3 azone doubly mixes, grind altogether dissolving into powder, get oil solution, oil solution is joined in the solution that obtains previously, sealing, 40 ℃ of insulated and stirred 30min obtain liniment.
Embodiment 5 acute toxicity testings
50 of Cavia porcelluss (being provided by Qingdao City's laboratory animal and zoopery center) are provided, male and female half and half, body weight is 250g ~ 300g, be divided into 5 groups, every group 10, wherein 1 group of Cavia porcellus is the blank group, other four groups of washing liquids 1 of smearing respectively 0.70ml/kg embodiment 1 to embodiment 3 preparation are to washing liquid 3 (smearing method of washing liquid is: soak is in the 30min of skin lesion place after soaking medicinal liquid according to the skin lesion size with hospital gauze), smear the liniment 1 of 0.70ml/kg embodiment 4 preparations, 24h before administration, with spinal column both sides, back unhairing (losing hair or feathers with 10% sodium sulfide after the first cropping), scope is slightly larger than 6 * 6cm.24h checks whether skin of unhairing is injured after the unhairing, injured skin should not be made the toxicity test of intact skin, the making of damaged skin adopts coarse sandpaper that unhairing is sterilized skin abrasion take Seepage blood as degree, then smear washing liquid and liniment at the unhairing place, begin to observe the general reaction situation behind the 24h, continuously 7d.The body weight of record animal, skin and hair, the variation of eye and mucosa, the observation of poisoning manifestations is identical with the acute toxicity testing of whole body administration.To the animal of death is arranged, in time dissect, there is macroscopic pathological changes to carry out histopathologic examination, the result shows, the animal mental status, activity, breathing, diet, feces and body weight gain are all normal in the 7d, without performances such as secretions increases, without animal dead, observation period finishes to put to death the spoil perusal, and administration group group and matched group Cavia porcellus are showed no the internal organs ANOMALOUS VARIATIONS.
Embodiment 6 long term toxicity tests
50 of Cavia porcelluss (being provided by Qingdao City's laboratory animal and zoopery center) are provided, male and female half and half, body weight is 250g ~ 300g, be divided into 5 groups, every group 10, wherein smear intact skin for two groups, smear respectively washing liquid 1 (smearing method as described in Example 5) and liniment 1, the applying amount of washing liquid is 0.70ml/kg, the applying amount of powder is 0.70ml/kg, smear damaged skin for two groups, smear respectively washing liquid 1 and liniment 1, the applying amount of washing liquid is 0.70ml/kg, the applying amount of liniment is 0.70g/kg, remaining one group is matched group, and Cavia porcellus is spinal column both sides, 24h back unhairing before administration, and area is slightly larger than 6cm * 6cm.The making of damaged skin adopts coarse sandpaper scratch ， take Seepage blood as degree, and then by the group administration, be administered once every day, contacts skin 6h at every turn, successive administration 30d.Observe every day such as administration local skin and animal behavior activity, the mental status, food-intake, feces character etc.Weighed once in per 3 days, and adjust dosage by body weight.24h after the last administration puts to death 6 animals for every group and carries out hematology, blood biochemical and the inspection of pathology indices.Remaining animal is all put to death after making drug withdrawal recovery observation 15d, detects indices.The result shows, more than every observation index abnormal change does not appear, or animal dead.Perusal: splanchnocoel is without oozing of blood, the organ administration group such as the heart, liver, kidney and matched group relatively, the aspects such as its color and luster, size, form are all without significant difference.Histological observation: it is normal that the heart, liver, nephridial tissue structure are respectively organized in administration, do not find obvious pathological change with matched group.
Embodiment 7 Experiments of Zoology
Animal
280 of kunming mices (being provided by Qingdao City's laboratory animal and zoopery center), female half and half, body weight 18～22g, be divided into immediately 14 groups, every group 20, wherein 7 groups of impacts that are used for observing xylol induced mice auricle edema are respectively blank group, model control group, positive controls, treatment group 1 to treatment group 4,7 groups of impacts that are used for observing the mice delayed hypersensitivity are respectively blank group, model control group, positive controls, treatment group 5 to treatment group 8.
Reagent
Dimethylbenzene: Qingdao and nation's chemical industry company limited provide; Dinitrochlorobenzene (DNCB): Qingdao and nation's chemical industry company limited provide; Acetone: Qingdao and nation's chemical industry company limited provide; During experiment acetone is mixed with 1% and 5% DNFB (DNCB) acetone soln; Histamine phosphate: Shanghai gold fringe bio tech ltd provides; CGRP test kit: Beijing Fu Rui bio-engineering corporation.
Medicine
Treatment group 1 mice is smeared the washing liquid 1 of the embodiment of the invention 1 preparation, treatment group 2 mices are smeared the washing liquid 2 of the embodiment of the invention 2 preparations, treatment group 3 mices are smeared the washing liquid 3 of the embodiment of the invention 3 preparations, applying amount is 0.05ml/, treatment group 4 is smeared the liniment 1 of the embodiment of the invention 4 preparations, applying amount is 0.05ml/, the smearing method of washing liquid as described in Example 5, the positive controls fluocinonide ointment, applying amount is 0.05ml/, and model control group and blank group give isometric normal saline.
Statistical method
Measurement data adopts
χ is relatively adopted in expression between group
2Check, all data all adopt the SPSS12.0 statistical software to process.
Method and result
The impact of xylol induced mice auricle edema
During experiment, each treatment group and positive controls are all smeared administration in auris dextra section, every day 1 time, continuous 7 days, the washing liquid applying amount was 0.05ml/, and the liniment applying amount is 0.05ml/, 30min after the last administration, with distilled water flush away medicine, clean with dry cotton ball, except the blank group, all the other each groups are all dripped dimethylbenzene 50 μ l in two sides, mouse right ear front and back and are caused inflammation, put to death mice behind the 1h, punch in mice left and right sides ears same area with card punch (8mm), and the weight of minute another name both sides auricle, take the difference of two auricle weight as swelling, calculate and respectively organize swelling, carry out statistical procedures, the results are shown in Table 1.
The impact of the acute ear swelling of table 1 medicine xylol induced mice
| Group | n | Ear swelling degree (mg) |
| Model control group | 20 | 6.67±1.26 |
| Positive controls | 20 | 4.29±0.92 |
| Treatment group 1 | 20 | 1.08±0.39 |
| Treatment group 2 | 20 | 1.49±0.29 |
| Treatment group 3 | 20 | 1.37±0.58 |
| Treatment group 4 | 20 | 1.15±0.41 |
| The blank group | 20 | 0.33±0.05 |
As can be seen from Table 1, adopt the mice ear due to the Chinese medicine composition xylol of the present invention that remarkable inhibitory action is arranged.
The impact of the mice delayed hypersensitivity that DNFB (DNCB) is induced
Test the 1st day to model control group, positive controls, the treatment group 5 mouse web portion unhairing to treatment group 8, the about 2cm * 2cm of scope, and evenly smear the abdominal part sensitized mice with 5%DNCB solution 0.1ml.Strengthened 1 time in the 2nd day.After the sensitization 7 days, excite again the modeling success with 1%DNCB acetone soln 0.1ml.
After exciting each group medicinal liquid is coated with each mouse right ear, put to death mice behind the 24h, blank group and DNCB model group normal saline gavage, every day gavage, treatment group 5 mouse right ears are smeared the washing liquid 1 of the embodiment of the invention 1 preparation, treatment group 6 mouse right ears are smeared the washing liquid 2 of the embodiment of the invention 2 preparations, treatment group 7 mouse right ears are smeared the washing liquid 3 of the embodiment of the invention 3 preparations, applying amount is 0.5ml/, and treatment group 8 mouse right ears are smeared the liniment 1 of the embodiment of the invention 4 preparations, and applying amount is 0.5ml/, positive controls is taken fluocinonide ointment, applying amount is 0.05g/, every day 2 times, continuous 7 days.Put to death mice and take off left and right sides auricle with card punch (diameter 8mm), the scales/electronic balance weighing amount, take the difference of two ear weight as swelling, (1) swelling is respectively organized in calculating, (2) plasma C GRP concentration: get blood 1ml through eyeball, inject the test tube of 10%EDTA and aprotinin, mixing, 40 ℃, 3000r/min, 10min separated plasma are with the concentration of putting the method for exempting from and measure CGRP.Carry out statistical procedures, the results are shown in Table 2 and table 3.
The anti-Delayed onset allergy of table 2 medicine (type Ⅳ allergy) effect
| Group | n | Ear swelling degree (mg) |
| Model control group | 20 | 7.03±0.91 |
| Positive controls | 20 | 4.51±0.60 |
| Treatment group 5 | 20 | 1.27±0.38 |
| Treatment group 6 | 20 | 1.63±0.73 |
| Treatment group 7 | 20 | 1.46±0.52 |
| Treatment group 8 | 20 | 1.38±0.47 |
| The blank group | 20 | 0.33±0.10 |
Table 3 is on the impact of plasma C GRP
| Group | n | CGRP(pg/mL) |
| Model control group | 20 | 13.91±2.03 |
| Positive controls | 20 | 26.39±1.83 |
| Treatment group 5 | 20 | 36.02±2.47 |
| Treatment group 6 | 20 | 30.63±1.59 |
| Treatment group 7 | 20 | 31.09±1.21 |
| Treatment group 8 | 20 | 34.37±1.52 |
| The blank group | 20 | 38.07±1.51 |
Can find out from table 2 and table 3, adopt Chinese medicine composition of the present invention can significantly suppress mice Delayed onset allergy.
Medicine is on the impact of Cavia porcellus local skin pruritus
60 of healthy guinea pigs, (being provided by Qingdao City's laboratory animal and zoopery center), male and female half and half, body weight are 250g ~ 300g, are divided at random 6 groups by body weight, 10 every group.If model control group, positive controls, treatment group 9 is to treatment group 12, model control group gives isometric normal saline, every day 1 time, continuous 7 days, after shaving hair to each group Cavia porcellus right back instep, adopt washing liquid and the powder of the present invention's preparation to smear shaving the hair place, treatment group 9 is smeared the washing liquid 1 of embodiment 1 preparation, treatment group 10 is smeared the washing liquid 2 of embodiment 2 preparations, treatment group 11 is smeared the washing liquid 3 of embodiment 3 preparations, and treatment group 12 is smeared the liniment 1 of embodiment 4 preparations, and the smearing method of washing liquid illustrates in embodiment 5, positive controls is smeared fluocinonide ointment, washing liquid 1 is 0.05ml/ to the applying amount of washing liquid 3, and the applying amount of powder 1 and fluocinonide ointment is 0.05ml/, 1h after last administration in the 7th day, abrading right back instep with coarse sandpaper shaves hair and sentences slight oozing of blood degree of being, the about 1m of area
20.01% histamine phosphate's solution is dripped in beginning behind the 10min at the wound surface place, 0.05ml/ only, after this comply with 0.02%, 0.03%, 0.04% every 3min ... progressive concentration only is 0.05ml/ at every turn, later adds the metapedes instep until Cavia porcellus occurs, take histamine phosphate's total amount (μ g) of occurring at last being given when Cavia porcellus later licks the metapedes instep as itch-threshold, record and itch-threshold of relatively respectively organizing carry out statistical disposition, the results are shown in Table 4.
Table 4 medicine is on the impact of Cavia porcellus local skin pruritus
| Group | n | The threshold value of itching (μ g) |
| Model control group | 10 | 39.60±2.49 |
| Positive controls | 10 | 81.03±3.17 |
| Treatment group 9 | 10 | 135.09±2.26 |
| Treatment group 10 | 10 | 113.78±2.03 |
| Treatment group 11 | 10 | 115.62±2.91 |
| Treatment group 12 | 10 | 129.87±3.02 |
As can be seen from Table 4, adopt Chinese medicine composition of the present invention to have good itching-relieving action.
Embodiment 8 clinical experiments
Diagnosis basis
All cases meets the diagnostic criteria of the acute eczema in " traditional Chinese medical science disease Standardization of diagnosis and curative effect " (publication in 1994) that " skin cypridology " (People's Health Publisher publish, 2002) and State Administration of Traditional Chinese Medicine issue.
Physical data
Select the acute eczema between year December of March ~ 2011 in 2010 to suffer from 159 examples, male 82 examples wherein, women 77 examples, 18～67 years old age, the course of disease 3～10 days, average 7 days.Be divided at random treatment group (90 example) and matched group (69 example).Treatment group and matched group patient be in sex, the age, and the course of disease, skin lesion, the aspect there was no significant differences such as symptom have comparability.Above patient's Western medicine diagnose standard and tcm diagnosis standard all meet acute eczema.Exclusion standard: 1. Pregnant and lactant women; 2. merge serious systemic disease; 3. concurrent infection; 4. to observing drug allergy person; 5. a nearly week was used the antihistamine drug therapist; 6. used the corticosteroid hormone person in nearly 2 weeks.
Therapeutic Method
Treatment group is used washing liquid 1 treatment of the embodiment of the invention 1 preparation, soak is in the 30min of skin lesion place after soaking medicinal liquid according to the skin lesion size with hospital gauze, every day 3 times, the matched group skin lesion is coated with PIKANG SHUANG outside the place, erosion, the person of oozing out are arranged, 3% boric acid solution soak, every day 3 times, 1 course for the treatment of on the equal 7th, be used in conjunction 2 courses for the treatment of.
Therapeutic evaluation
By eczema area and severity index (EASI method) standards of grading to erythema, plumpness, skin lesion scope and lichenization carry out 4 grades of scoring: 0=without, 1=is slight, 2=moderate, 3=severe.The pruritus scoring: acute pruritus, affecting live and work is 3 minutes; Pruritus but to restrain oneself be 2 minutes; Slight pruritus is 1 minute; It is 0 minute without gargalesthesia.Symptom integral decline index (SSRI)=[integration before (integration after integration before the treatment-treatment)/treatment] * 100%.Recovery from illness: SSRI 〉=95%, pruritus disappears; Produce effects: SSRI=60% ~ 94%, pruritus obviously alleviates; Effectively: SSRI=20% ~ 59%, pruritus alleviates; Invalid: SSRI＜20%, pruritus is front or aggravation with treatment.With recovery from illness, produce effects and effectively percent as total effective rate.Carry out efficacy evaluation after treating 2 courses for the treatment of.
Statistical method
Measurement data adopts X ± s to represent, relatively adopts χ between group
2Check, all data all adopt the SPSS12.0 statistical software to process.
The result
2 groups of Clinical efficacy comparisons the results are shown in Table 5.
Table 52 group patient clinical curative effect relatively
| Group | n | Recovery from illness | Produce effects | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 90 | 32 | 20 | 23 | 15 | 83.3 |
| Matched group | 69 | 16 | 19 | 13 | 21 | 69.6 |
The EASI integral contrast the results are shown in Table 6 before and after the treatment.
EASI integral contrast before and after the treatment of table 62 group
| Group | n | Before the treatment | After the treatment |
| Treatment group | 90 | 8.1±1.6 | 3.7±0.5 |
| Matched group | 69 | 7.7±0.4 | 5.5±0.7 |
Can find out that from table 5 and table 6 effect that adopts external medicine composition of the present invention to treat will be significantly better than adopting treatment with western.
Cured person is followed up a case by regular visits to 6 months recurrences relatively, sees Table 7.
Table 7 cured person is followed up a case by regular visits to 6 months recurrences relatively
| Group | The recovery from illness number | The recurrence number | Relapse rate (%) |
| Treatment group | 57 | 4 | 7.02 |
| Treatment group | 32 | 5 | 15.63 |
As can be seen from Table 7, adopt patient's the relapse rate of external medicine composition of the present invention treatment much lower with respect to the Western medicine group, prove that it is difficult for recurrence.
2 groups of patient's prurituss disappear, the comparison of deflorescence time, see Table 8.
Table 8 patient pruritus disappears, the deflorescence time
| Group | n | Pruritus extinction time (d) | The deflorescence time (d) |
| Treatment group | 120 | 5.2±0.7 | 6.4±1.1 |
| Matched group | 110 | 7.2±1.2 | 9.5±1.6 |
Table 8 can be found out, adopts external medicine composition treatment of the present invention can shorten pruritus extinction time and deflorescence time.
This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away to any simple modification, equivalent variations and remodeling that above embodiment does, still belongs to the protection domain of technical solution of the present invention according to technical spirit of the present invention.
Claims (10)
1. external medicine composition that is used for the treatment of acute eczema, it is characterized in that: the crude drug in the described Chinese medicine composition comprises Radix Et Rhizoma Rhei, Radix Scutellariae, the Fructus Kochiae, Rhizoma Et Radix Notopterygii, Folium Isatidis, Rhizoma Picrorhizae, Herba Eupatorii, catechu, Fructus Cnidii, Sargassum, Radix Ampelopsis, Folium Et Cacumen Murrayae, the Radix Paeoniae Alba, Periostracum Cicadae, Semen Torreyae, Folium Crataegi, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Lobeliae Chinensis, Caulis Spatholobi, Stigma Croci, Radix Angelicae Sinensis, Myrrha, Rhizoma Corydalis Decumbentis.
2. external medicine composition as claimed in claim 1, it is characterized in that: the weight portion of each crude drug is respectively Radix Et Rhizoma Rhei 30 weight portions ~ 40 weight portions in the described external medicine composition, Radix Scutellariae 75 weight portions ~ 85 weight portions, the Fructus Kochiae 30 weight portions ~ 40 weight portions, Rhizoma Et Radix Notopterygii 20 weight portions ~ 30 weight portions, Folium Isatidis 60 weight portions ~ 70 weight portions, Rhizoma Picrorhizae 25 weight portions ~ 35 weight portions, Herba Eupatorii 15 weight portions ~ 25 weight portions, catechu 20 weight portions ~ 30 weight portions, Fructus Cnidii 30 weight portions ~ 40 weight portions, Sargassum 20 weight portions ~ 30 weight portions, Radix Ampelopsis 25 weight portions ~ 35 weight portions, Folium Et Cacumen Murrayae 20 weight portions ~ 30 weight portions, the Radix Paeoniae Alba 75 weight portions ~ 85 weight portions, Periostracum Cicadae 15 weight portions ~ 25 weight portions, Semen Torreyae 10 weight portions ~ 20 weight portions, Folium Crataegi 25 weight portions ~ 35 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 20 weight portions ~ 30 weight portions, Herba Lobeliae Chinensis 35 weight portions ~ 45 weight portions, Caulis Spatholobi 45 weight portions ~ 55 weight portions, Stigma Croci 30 weight portions ~ 40 weight portions, Radix Angelicae Sinensis 50 weight portions ~ 60 weight portions, Myrrha 25 weight portions ~ 35 weight portions, Rhizoma Corydalis Decumbentis 20 weight portions ~ 30 weight portions.
3. external medicine composition as claimed in claim 1 or 2, it is characterized in that: the weight portion of each crude drug is respectively Radix Et Rhizoma Rhei 33 weight portions ~ 37 weight portions in the described external medicine composition, Radix Scutellariae 78 weight portions ~ 82 weight portions, the Fructus Kochiae 33 weight portions ~ 37 weight portions, Rhizoma Et Radix Notopterygii 23 weight portions ~ 27 weight portions, Folium Isatidis 63 weight portions ~ 67 weight portions, Rhizoma Picrorhizae 28 weight portions ~ 32 weight portions, Herba Eupatorii 18 weight portions ~ 22 weight portions, catechu 23 weight portions ~ 27 weight portions, Fructus Cnidii 33 weight portions ~ 37 weight portions, Sargassum 23 weight portions ~ 27 weight portions, Radix Ampelopsis 28 weight portions ~ 32 weight portions, Folium Et Cacumen Murrayae 23 weight portions ~ 27 weight portions, the Radix Paeoniae Alba 78 weight portions ~ 82 weight portions, Periostracum Cicadae 18 weight portions ~ 22 weight portions, Semen Torreyae 13 weight portions ~ 17 weight portions, Folium Crataegi 28 weight portions ~ 32 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 23 weight portions ~ 27 weight portions, Herba Lobeliae Chinensis 38 weight portions ~ 42 weight portions, Caulis Spatholobi 48 weight portions ~ 52 weight portions, Stigma Croci 33 weight portions ~ 37 weight portions, Radix Angelicae Sinensis 53 weight portions ~ 57 weight portions, Myrrha 28 weight portions ~ 32 weight portions, Rhizoma Corydalis Decumbentis 23 weight portions ~ 27 weight portions.
4. such as the described external medicine composition of claims 1 to 3, it is characterized in that: the weight portion of each crude drug is respectively Radix Et Rhizoma Rhei 35 weight portions in the described external medicine composition, Radix Scutellariae 80 weight portions, the Fructus Kochiae 35 weight portions, Rhizoma Et Radix Notopterygii 25 weight portions, Folium Isatidis 65 weight portions, Rhizoma Picrorhizae 30 weight portions, Herba Eupatorii 20 weight portions, catechu 25 weight portions, Fructus Cnidii 35 weight portions, Sargassum 25 weight portions, Radix Ampelopsis 30 weight portions, Folium Et Cacumen Murrayae 25 weight portions, the Radix Paeoniae Alba 80 weight portions, Periostracum Cicadae 20 weight portions, Semen Torreyae 15 weight portions, Folium Crataegi 30 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 25 weight portions, Herba Lobeliae Chinensis 40 weight portions, Caulis Spatholobi 50 weight portions, Stigma Croci 35 weight portions, Radix Angelicae Sinensis 55 weight portions, Myrrha 30 weight portions, Rhizoma Corydalis Decumbentis 25 weight portions.
5. such as the described external medicine composition of claim 1 to 4, it is characterized in that: the dosage form of described external medicine composition can be washing liquid, unguentum, oil preparation, liniment, tincture, cream, gel.
6. the preparation method of the described external medicine composition of claim 1 to 5 is characterized in that: when the dosage form of described external medicine composition is washing liquid, is specially,
Described each crude drug component is mixed in proportion, adding is with respect to the distilled water of 6 ~ 8 times of mixture qualities, soak first 20min ~ 40min, pour in the volatile oil extractor, the way of distillation is extracted volatile oil 4 ~ 6h, obtains volatile oil, remaining water extraction liquid filters, obtain filtrate, in filtering residue, again add the distilled water with respect to 3 ~ 5 times of its quality, decoct 2h ~ 3h, the decoction liquor that obtains is filtered again, obtain filtrate, filtrate is merged, adding determining alcohol and be 70% ~ 80% ethanol to alcohol volume content, to account for total liquor capacity be 40% ~ 50% (V/V), add the volatile oil that obtains previously, stir, regulating pH value is 7.0 ~ 7.5, leaves standstill precipitate with ethanol, filter, filtrate is concentrated into without the alcohol flavor, and adding distilled water to crude drug concentration is 1g/ml ~ 2g/ml, obtains washing liquid.
7. the preparation method of the described external medicine composition of claim 1 to 5 is characterized in that: when the dosage form of described external medicine composition is liniment, is specially,
The first step is mixed in proportion each crude drug component in the described external medicine composition, adds normal hexane, and extraction obtains oils and fats;
Second step, normal hexane is removed in the oven dry of crude drug mixture behind the oil and grease extracting, adding is with respect to the ethanol of 2 ~ 4 times of determining alcohols 70% ~ 80% of crude drug mixture quality, heating and refluxing extraction 2 ~ 3 times, each 2 ~ 4h that extracts, extracting solution merges, filters, and adds glycerol, obtain solution, the weight portion that glycerol adds is 0.5 weight portion ~ 1 weight portion with respect to 100 weight portion crude drug mixture;
In the 3rd step, the oils and fats that the first step is obtained mixes with lecithin, azone, grinds altogether dissolving into powder, gets oil solution, and the quality of the lecithin that adds is 0.5 times ~ 1 times of oil quality, and the azone quality that adds is 0.2 times ~ 0.4 times of oil quality;
In the 4th step, the oils and fats that the 3rd step was obtained joins in the solution of second step acquisition, sealing, and 40 ℃ of insulated and stirred 20min ~ 30min obtain liniment.
8. the preparation method of external medicine composition claimed in claim 7, it is characterized in that: each crude drug component that the described first step further is specially described external medicine composition is mixed in proportion, and in the extractor of packing into, adds normal hexane to just flooding, soak 40min ~ 60min, under agitation extract 40min ~ 60min, emit n-hexane extract, re-extract once again, combining extraction liquid, filter, normal hexane is reclaimed in evaporation, obtains oils and fats.
9. the using method of the washing liquid of the described external medicine composition preparation method of claim 6 preparation, the spy is characterised in that, is specially:
Soak is in the 20min ~ 30min of skin lesion place after soaking medicinal liquid according to the skin lesion size with hospital gauze.
The described external medicine composition of claim 1 to 5 for the preparation of the treatment acute eczema medicine in application.
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| CN110327441A (en) * | 2019-06-18 | 2019-10-15 | 山东中医药大学第二附属医院 | A kind of Chinese medicine line spices directly acting on body surface and preparation method |
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