CN109833411A - A kind of rose essence oil and preparation method thereof for alleviating dysmenorrhea - Google Patents
A kind of rose essence oil and preparation method thereof for alleviating dysmenorrhea Download PDFInfo
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Abstract
The present invention provides a kind of rose essence oil and preparation method thereof for alleviating dysmenorrhea, belongs to essential oil composition technical field.The rose essence oil includes the raw material of following mass fraction: rose hip oil 30%-50%, sunflower oil 30%-40%, yam extract 3%-7%, Pelargonium roseum extract 2%-6%, aloe 3%-5%, Leonurus extract 1%-6%, angelica extract 2%-5%, Rhizoma Chuanxiong extract 1%-4%, Rosa Damascana 1%-4%, root of three-nerved spicebush essential oil 0.5%-1.5%, vitamin E 0.5%-1.5%.The present invention has obvious spasmolysis to the spasm of isolated uterine smooth muscle, and has apparent analgesic activity, can significantly reduce women menses prostaglandin level, have preferable relaxation effect to dysmenorrhea.
Description
Technical field
The invention belongs to essential oil composition technical fields, and in particular to a kind of rose essence for alleviating dysmenorrhea is oily and its prepares
Method.
Background technique
Menstrual cycle is wane and wax of yin and yang, the embodiment of the qi and blood variation rhythm and pace of moving things during female pathology.Chinese medicine think dysmenorrhea mostly because
Menstrual period sense is cold to paddle, and cold-damp invading in the interior,inward invasion of cold-damp uterus, menses are stagnated by cold-dampness, and discharge is unsmooth, not general rule pain.Treatment for dysmenorrhea,
It is treated frequently with analgesic, calmness and prostaglandin inhibitor, although taking effect quick, side effect is big, and curative effect is difficult to hold
Long.Dysmenorrhea is one of most common gynaecology's symptom, refers to before and after passing through or lower abdominal pain, falling inflation occurs in the menstrual period, with the soreness of waist
Or other are uncomfortable, serious symptom influences quality of life person.Dysmenorrhea is divided into primary dysmenorrhea and secondary two class, and primary dysmenorrhea refers to
Dysmenorrhea of the reproductive organs without organic disease accounts for 90% or more dysmenorrhea；Acquired dysmenorrhea refers to as caused by pelvic cavity organic disease
Dysmenorrhea.The cause of disease: the generation of 1. primary dysmenorrheas is mainly increased with endometrium Prostaglandin when menstruation related.PGF2 α contains
The main reason for amount causes dysmenorrhea when increasing.PGF2 alpha content height can cause the too strong contraction of uterine smooth muscle, and vasopasm causes
Uterus ischemic, anoxia state and there is dysmenorrhea.2. the increasing of the substances such as vasopressing, endogenous oxytocin and beta-endorphin
Add.3. spirit, neural factors.Symptom main cause: having a weak heart, and blood supply can not be made to body tip position.Anaemia, qi and blood are not
Foot, ferroheme and red blood cell are relatively low.There are obstruction, or fever, flu etc. that can all influence brain centres nerve in blood vessel, leads to trick
Dysmenorrhea.Sympathetic nerve function is out of joint, tighten muscle can not to the cold, generates thermal energy with cold-resistant.
Now there is the drug for treating the illness many and diverse on the market, but because Western medicine preparation is long there are treatment time, side effect is big, easy
Repeatedly, effect is undesirable, is increasingly abandoned by people；As the saying goes: " there's no such thing as a totally safe medicine." Chinese herbal medicine is even used, also can
The burden of the internal organs such as stomach, liver, kidney is aggravated, and plants essential oil molecule can absorb nerve by skin, on the one hand, dominating neural rises
To the neururgic function of adjusting；On the other hand, blood is entered by blood circulation and is delivered directly to each position of whole body, to rise
To the effect for alleviating symptom.
Summary of the invention
The present invention by providing a kind of rose essence oil and preparation method thereof for alleviating dysmenorrhea, solve using Chinese medicine or
Western medicine dysmenorrhea, the problem that effect is undesirable and side effect is big, by rational allocation essence oil formula, through vitro skin or
Respiratory system absorbs the purpose for playing and alleviating dysmenorrhea symptom.
To achieve the above object, the technical solution of the invention is as follows:
A kind of rose essence oil for alleviating dysmenorrhea, the raw material including following mass fraction: rose hip oil 30%-50%, certain herbaceous plants with big flowers
Flower seed oil 30%-40%, yam extract 3%-7%, Pelargonium roseum extract 2%-6%, aloe 3%-5%, benefit are female
Careless extract 1%-6%, angelica extract 2%-5%, Rhizoma Chuanxiong extract 1%-4%, Rosa Damascana 1%-4%, root of three-nerved spicebush essential oil
0.5%-1.5%, vitamin E 0.5%-1.5%.
Preferably, the raw material including following mass fraction: rose hip oil 40%, sunflower oil 35%, yam extract
5%, Pelargonium roseum extract 4%, aloe 3.5%, Leonurus extract 3%, angelica extract 3%, Rhizoma Chuanxiong extract
2%, Rosa Damascana 2.5%, root of three-nerved spicebush essential oil 1%, vitamin E 1%.
The present invention also provides a kind of preparation methods of rose essence oil for alleviating dysmenorrhea, comprising the following steps:
S1: rose hip oil is weighed by quality proportioning, sunflower oil is put into clean agitated kettle and stirs at low speed；
S2: vitamin E, yam extract, aloe, Pelargonium roseum extract, Radix Angelicae Sinensis successively are weighed by quality proportioning
Agitated kettle was added in extract, Rhizoma Chuanxiong extract, Leonurus extract, root of three-nerved spicebush essential oil, with moderate-speed mixer 20-30 minutes；
S3: weighing Rosa Damascana by quality proportioning and be added in agitated kettle, continues to stop stirring after moderate-speed mixer 8-15 minutes
It mixes；
S4: filtering removes impurity；
S5: filling to get finished product after still aging 24 hours.
Preferably, it is stirred in the step S1 with the speed of 20-40r/min.
Preferably, it is stirred 25 minutes in the step S2 with the speed of 80-100r/min.
Preferably, it is stirred 10 minutes in the step S3 with the speed of 80-100r/min.
Preferably, filtered on buchner funnel is used in the step S4.
Have effects that in inventive formulation raw material following:
Rose hip oil and sunflower oil have the function of moisturizing the skin；Vitamin E has work that is anti-oxidant, removing free radical
With；Yam extract has the function of nourishing qi and blood；Aloe plays the role of antiphlogistic antibacterial；Pelargonium roseum extract has antibacterial
The effect of analgesic；Angelica extract plays the role of menstruction regulating and pain relieving；Rhizoma Chuanxiong extract plays the role of activating microcirculation and removing stasis medicinal；Leonurus extract
There are promoting blood circulation for regulating menstruation, the effect of skin maintenance and cosmetic benefits；Root of three-nerved spicebush essential oil plays the role of promoting qi circulation and relieving pain；Rosa Damascana have adjust female incretion,
The effect nourished uterus, alleviate dysmenorrhea, skin maintenance and cosmetic benefits.
The beneficial effects of the present invention are:
(1) it in the rose essence oil formula of alleviation dysmenorrhea of the invention, is given birth to by using rose hip oil, sunflower oil, dimension
Plain E, yam extract, aloe, Pelargonium roseum extract, angelica extract, Rhizoma Chuanxiong extract, Leonurus extract, crow
The coordinated of medicine essential oil and Rosa Damascana, it is common to play the effect for alleviating dysmenorrhea, not only there is very strong fat-soluble and infiltration
Ability can be such that body quickly absorbs, by external medication, alleviation dysmenorrhea that can be safe and efficient.
(2) preparation method of the rose essence oil provided by the invention for alleviating dysmenorrhea is simple, easy to operate, can be suitable for
Industrialized production, high production efficiency.
Specific embodiment
For a better understanding of the technical solution of the present invention, below in conjunction with specific embodiment to technology of the invention
Scheme is described in detail.
In following embodiment, the rose essence oil of the alleviation dysmenorrhea, the raw material including following mass fraction: fructus rosae
Oily 30%-50%, sunflower oil 30%-40%, yam extract 3%-7%, Pelargonium roseum extract 2%-6%, aloe
Oily 3%-5%, Leonurus extract 1%-6%, angelica extract 2%-5%, Rhizoma Chuanxiong extract 1%-4%, Rosa Damascana
1%-4%, root of three-nerved spicebush essential oil 0.5%-1.5%, vitamin E 0.5%-1.5%.
The preparation method of the rose essence oil of the alleviation dysmenorrhea, comprising the following steps:
S1: rose hip oil is weighed by quality proportioning, sunflower oil is put into clean agitated kettle with the speed of 20-40r/min
Degree stirs evenly；
S2: vitamin E, yam extract, aloe, Pelargonium roseum extract, Radix Angelicae Sinensis successively are weighed by quality proportioning
Agitated kettle is added in extract, Rhizoma Chuanxiong extract, Leonurus extract, root of three-nerved spicebush essential oil, stirs 20- with the speed of 80-100r/min
30 minutes；
S3: weighing Rosa Damascana by quality proportioning and be added in agitated kettle, continues to stir 8-15 with the speed of 80-100r/min
Stop stirring after minute；
S4: using filtered on buchner funnel, removes impurity；
S5: filling to get finished product after still aging 24 hours.
Embodiment 1
A kind of rose essence oil for alleviating dysmenorrhea, the raw material including following mass fraction: rose hip oil 38%, sunflower oil
30%, yam extract 7%, Pelargonium roseum extract 2%, aloe 5%, Leonurus extract 4%, angelica extract
5%, Rhizoma Chuanxiong extract 1%, Rosa Damascana 3%, root of three-nerved spicebush essential oil 1.5%, vitamin E 1%.
The preparation method of the rose essence oil of the alleviation dysmenorrhea, comprising the following steps:
S1: rose hip oil is weighed by quality proportioning, sunflower oil is put into clean agitated kettle and is stirred with the speed of 20r/min
It mixes uniformly；
S2: vitamin E, yam extract, aloe, Pelargonium roseum extract, Radix Angelicae Sinensis successively are weighed by quality proportioning
Agitated kettle is added in extract, Rhizoma Chuanxiong extract, Leonurus extract, root of three-nerved spicebush essential oil, is stirred 30 minutes with the speed of 90r/min；
S3: weighing Rosa Damascana by quality proportioning and be added in agitated kettle, continues after being stirred 12 minutes with the speed of 80r/min
Stop stirring；
S4: using filtered on buchner funnel, removes impurity；
S5: filling to get finished product after still aging 24 hours.
Embodiment 2
A kind of rose essence oil for alleviating dysmenorrhea, the raw material including following mass fraction: rose hip oil 50%, sunflower oil
35%, yam extract 3%, Pelargonium roseum extract 5%, aloe 3%, Leonurus extract 6%, angelica extract
2%, Rhizoma Chuanxiong extract 3%, Rosa Damascana 4%, root of three-nerved spicebush essential oil 0.5%, vitamin E 1.5%.
The preparation method of the rose essence oil of the alleviation dysmenorrhea, comprising the following steps:
S1: rose hip oil is weighed by quality proportioning, sunflower oil is put into clean agitated kettle and is stirred with the speed of 30r/min
It mixes uniformly；
S2: vitamin E, yam extract, aloe, Pelargonium roseum extract, Radix Angelicae Sinensis successively are weighed by quality proportioning
Agitated kettle is added in extract, Rhizoma Chuanxiong extract, Leonurus extract, root of three-nerved spicebush essential oil, is stirred 20 minutes with the speed of 100r/min；
S3: weighing Rosa Damascana by quality proportioning and be added in agitated kettle, continues after being stirred 15 minutes with the speed of 90r/min
Stop stirring；
S4: using filtered on buchner funnel, removes impurity；
S5: filling to get finished product after still aging 24 hours.
Embodiment 3
A kind of rose essence oil for alleviating dysmenorrhea, the raw material including following mass fraction: rose hip oil 30%, sunflower oil
40%, yam extract 5%, Pelargonium roseum extract 6%, aloe 4%, Leonurus extract 1%, angelica extract
4%, Rhizoma Chuanxiong extract 4%, Rosa Damascana 1%, root of three-nerved spicebush essential oil 1%, vitamin E 0.5%.
The preparation method of the rose essence oil of the alleviation dysmenorrhea, comprising the following steps:
S1: rose hip oil is weighed by quality proportioning, sunflower oil is put into clean agitated kettle and is stirred with the speed of 40r/min
It mixes uniformly；
S2: vitamin E, yam extract, aloe, Pelargonium roseum extract, Radix Angelicae Sinensis successively are weighed by quality proportioning
Agitated kettle is added in extract, Rhizoma Chuanxiong extract, Leonurus extract, root of three-nerved spicebush essential oil, is stirred 25 minutes with the speed of 80r/min；
S3: weighing Rosa Damascana by quality proportioning and be added in agitated kettle, continues after being stirred 8 minutes with the speed of 100r/min
Stop stirring；
S4: using filtered on buchner funnel, removes impurity；
S5: filling to get finished product after still aging 24 hours.
Embodiment 4
A kind of rose essence oil for alleviating dysmenorrhea, the raw material including following mass fraction: rose hip oil 40%, sunflower oil
35%, yam extract 5%, Pelargonium roseum extract 4%, aloe 3.5%, Leonurus extract 3%, angelica extract
3%, Rhizoma Chuanxiong extract 2%, Rosa Damascana 2.5%, root of three-nerved spicebush essential oil 1%, vitamin E 1%.
The preparation method of the rose essence oil of the alleviation dysmenorrhea, comprising the following steps:
S1: rose hip oil is weighed by quality proportioning, sunflower oil is put into clean agitated kettle and is stirred with the speed of 30r/min
It mixes uniformly；
S2: vitamin E, yam extract, aloe, Pelargonium roseum extract, Radix Angelicae Sinensis successively are weighed by quality proportioning
Agitated kettle is added in extract, Rhizoma Chuanxiong extract, Leonurus extract, root of three-nerved spicebush essential oil, is stirred 30 minutes with the speed of 80r/min；
S3: weighing Rosa Damascana by quality proportioning and be added in agitated kettle, continues with the speed stirring of 80r/min after ten minutes
Stop stirring；
S4: using filtered on buchner funnel, removes impurity；
S5: filling to get finished product after still aging 24 hours.
In order to verify effect of the invention, it is illustrated by following tests case:
Test example 1
Selection Healthy female non-pregnant rat 90, is randomly divided into 6 groups, every group 15,0.2mg/100g skin is given before experiment
Lower injection diethylstilbestrol takes uterus, clip uterus 2cm, by it with the rapid solution of ether inhalation anesthesia after injection 3 days 1 time a day
It is placed in the sulculus for filling 30ml Rockwell liquid, water-bath is kept for 35-37 DEG C, and oxygen is passed through into slot, is recorded and analyzed with bio signal
System records normal contraction curve, and the rose essence oil 1g/kg in embodiment 1-4 is added in experimental group, and control group is given commercially available
Herba Leonuri granule 1g/kg, blank control group give the distilled water 1g/kg of same dose, uterotonic frequency before and after observation medication
Rate, amplitude, the results are shown in Table 1.
Uterotonic frequency, amplitude contrast table before and after 1 medication of table
| Group | Frequency (secondary/10 points) | Amplitude (mm) |
| Embodiment 1 | 4.56±3.21 | 3.86±1.21 |
| Embodiment 2 | 4.85±2.36 | 3.76±2.31 |
| Embodiment 3 | 5.12±1.25 | 4.02±1.13 |
| Embodiment 4 | 4.55±2.42 | 3.68±1.14 |
| Control group | 6.32±1.35 | 4.24±1.08 |
| Blank control group | 9.54±2.38 | 6.32±1.22 |
The above result shows that rose essence oil is relative to control group drug to uterus made from 1-4 of the embodiment of the present invention
Spasmolysis becomes apparent from (P < 0.05), and rose essence oil made from embodiment 4 to alleviate uterine smooth muscle contractive effect most
It is good.
Test example 2
Taking weight is mouse 60 of 20-25g, is randomly divided into 3 groups, and every group 20, blank control group gives distilled water, real
Test the rose essence oil that group gives embodiment 4, control group gives Herba Leonuri granule, when test respectively by different pharmaceutical 50mg/ only,
It smears at mouse web portion skin of unhairing, the acetum 0.2ml/ of mouse difference abdominal cavity registration 0.6% only, is seen after one hour
The pain writhing number in every mouse 10 minutes is examined, the results are shown in Table shown in 2.
The writhing number table of comparisons in 2 each group mouse of table 10 minutes
| Group | Writhing number | Writhing response incidence (%) |
| Experimental group | 5.25±4.63 | 70 |
| Control group | 5.83±4.52 | 80 |
| Blank control group | 15.75±4.38 | 100 |
As seen from the above table, experimental group is compared with blank control group, can significantly reduce the writhing number of mouse, surface have compared with
Good analgesic effect.
Test example 3
80 people of female patient with dysmenorrhea history is selected, the age is 18-30 years old, experimental group and each 40 people of control group are set,
Experimental group patient smears the rose essence oil of the embodiment of the present invention 4 when dysmenorrhea in its underbelly, and control group smears equivalent
Distilled water detects and records the horizontal through pretherapy and post-treatment menses prostaglandin (PGF2a) of patient, the results are shown in Table shown in 3.
Table 3 is horizontal (x ± s, pg/ml) through pretherapy and post-treatment menses prostaglandin (PGF2a)
The above result shows that experimental group can significantly reduce prostaglandin level after the treatment, illustrate rose of the invention
Essential oils have preferable relaxation effect to dysmenorrhea.
From the above test example it is found that the present invention at least has the effect that
1. the spasm of pair isolated uterine smooth muscle has obvious spasmolysis；
2. having apparent analgesic activity；
3. women menses prostaglandin level can be significantly reduced, there is preferable relaxation effect to dysmenorrhea.
The above description is only an embodiment of the present invention, is not intended to limit the scope of the invention, all to utilize this hair
Equivalent transformation made by bright description is applied directly or indirectly in other relevant technical fields, is similarly included in
In scope of patent protection of the invention.
Claims (7)
1. a kind of rose essence oil for alleviating dysmenorrhea, which is characterized in that the raw material including following mass fraction: rose hip oil
30%-50%, sunflower oil 30%-40%, yam extract 3%-7%, Pelargonium roseum extract 2%-6%, aloe
3%-5%, Leonurus extract 1%-6%, angelica extract 2%-5%, Rhizoma Chuanxiong extract 1%-4%, Rosa Damascana 1%-
4%, root of three-nerved spicebush essential oil 0.5%-1.5%, vitamin E 0.5%-1.5%.
2. the rose essence oil according to claim 1 for alleviating dysmenorrhea, which is characterized in that the original including following mass fraction
Material: rose hip oil 40%, sunflower oil 35%, yam extract 5%, Pelargonium roseum extract 4%, aloe 3.5%, benefit
Brittle Falsepimpernel Herb extract 3%, angelica extract 3%, Rhizoma Chuanxiong extract 2%, Rosa Damascana 2.5%, root of three-nerved spicebush essential oil 1%, vitamin E
1%.
3. a kind of preparation method of the rose essence oil according to claim 1 or 2 for alleviating dysmenorrhea, which is characterized in that packet
Include following steps:
S1: rose hip oil is weighed by quality proportioning, sunflower oil is put into clean agitated kettle and stirs at low speed；
S2: vitamin E, yam extract, aloe, Pelargonium roseum extract, Radix Angelicae Sinensis successively are weighed by quality proportioning and is extracted
Agitated kettle was added in object, Rhizoma Chuanxiong extract, Leonurus extract, root of three-nerved spicebush essential oil, with moderate-speed mixer 20-30 minutes；
S3: weighing Rosa Damascana by quality proportioning and be added in agitated kettle, continues to stop stirring after moderate-speed mixer 8-15 minutes；
S4: filtering removes impurity；
S5: filling to get finished product after still aging 24 hours.
4. the preparation method of the rose essence oil according to claim 3 for alleviating dysmenorrhea, which is characterized in that the step S1
In stirred with the speed of 20-40r/min.
5. the preparation method of the rose essence oil according to claim 3 for alleviating dysmenorrhea, which is characterized in that the step S2
In stirred 25 minutes with the speed of 80-100r/min.
6. the preparation method of the rose essence oil according to claim 3 for alleviating dysmenorrhea, which is characterized in that the step S3
In stirred 10 minutes with the speed of 80-100r/min.
7. the preparation method of the rose essence oil according to claim 3 for alleviating dysmenorrhea, which is characterized in that the step S4
It is middle to use filtered on buchner funnel.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111298088A (en) * | 2020-04-03 | 2020-06-19 | 联康卫仕健康管理(厦门)有限公司 | Spray for rapidly solving dysmenorrhea |
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| CN108815488A (en) * | 2018-08-10 | 2018-11-16 | 江西中医药大学 | Treat compound essential oil preparation of dysmenorrhea and preparation method thereof and application method |
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2019
- 2019-03-15 CN CN201910197740.1A patent/CN109833411A/en active Pending
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| CN103006852A (en) * | 2011-09-26 | 2013-04-03 | 姚水莲 | Composite essential oil for relieving pain |
| CN106806877A (en) * | 2015-12-02 | 2017-06-09 | 所以（深圳）互联网科技有限责任公司 | Improve dysmenorrhoea Chinese medicine composition and preparation method thereof and drinks |
| CN107137499A (en) * | 2017-05-19 | 2017-09-08 | 广州传世生物科技有限公司 | It is a kind of to nurse one's health the hot compress powder bag that body supplements vigour |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111298088A (en) * | 2020-04-03 | 2020-06-19 | 联康卫仕健康管理(厦门)有限公司 | Spray for rapidly solving dysmenorrhea |
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Application publication date: 20190604 |