CN102068616B - Medicament for treating gynecological diseases and preparation method - Google Patents
Medicament for treating gynecological diseases and preparation method Download PDFInfo
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Abstract
The invention relates to a medicament for treating gynecological diseases and a preparation method, and the medicament is mainly prepared by the following active ingredients in parts by weight: 160-420 parts of bletilla striata, 160-420 parts of saffron, 180-450 parts of radix fici, 180-450 parts of longtube ground Ivy herb, 136-387 parts of Chinese gentian, 136-387 parts of twotooth achyranthes root, 136-387 parts of barbed skullcap herb, 136-387 parts of balsamiferou blumea herb, 136-387 parts of frankincense, 80-230 parts of figwort root, 65-230 parts of membranaceus beautyleaf root, 106-350 parts of Chinese taxillus twig, 106-350 parts of anemone clematis stem and 106-350 parts of plantain seed. Although the formula of the invention is complex, the medicament is applicable to various clinical symptoms, the treatment effect is stable, and the medicament is mainly used for treating irregular menstruation, dysmenorrhea, vaginitis, annexitis, pelvic inflammatory disease and endometritis of women caused by damp-heat stagnation. The formula composition is performed according to traditional Chinese medicine theory, so that the medicament can not only play a treatment role, but also avoid side effects.
Description
Technical field
The present invention relates to the Chinese medicine technical field of medicine, relate to a kind of drug compound preparation and method for preparing that is used to treat menoxenia, dysmenorrhea, adnexitis, pelvic inflammatory disease and endometritis due to the damp-heat accumulation in particular.
Background technology
Since the women experience menstruation in life, breed, physiological process such as nurture, women's physiological characteristics is also just determining the specificity of women's pathological changes.Current have more than 49% the women of child-bearing age in various degree suffer from gynaecopathia, and married women's sickness rate is up to 76%, and in rising trend.The main pathogenesis that gynaecopathia takes place; Promptly not normal with function, disorder of QI and blood, meridians damage are main; The dashing of eight extra-channel, core, superintend and direct, the direct or indirect damage of band and uterus, vessels of the uterus and collaterals of the uterus; Be the pathogenic characteristic that causes gynaecopathia to take place, gynaecopathia is how common with mass formed by blood stasis, such as dysmenorrhea, amenorrhea, metrorrhagia etc.; Because of caused by liver and kidney deficiency often causes the cold womb of suffering from a deficiency of the kidney, chills and pain of the waist and kness, leukorrhagia.
Chinese medicine preparation treatment gynecological diseases has special advantages, and treatment by Chinese herbs is with regulating YIN and YANG, tonifying for deficiency syndrome, reducing for the excess syndrome, recovery organic whole relative equilibrium, for treating the basic of disease.At present, clinical Amino-Cerv kind is more, and is how in the majority with treatment inflammation class medicine, relates to types such as Western medicine, Chinese patent medicine, Chinese medicine and western medicine mixture.Often a lot of gynaecopathias are multiple former thereby extremely, and generally only separately to a kind of disease, when various disease conditions took place jointly, the patient then need take high amount of drug every day to Western medicine.The Chinese medicine of some present treatment gynaecopathias also all emphasizes particularly on different fields; Therapeutic domain is narrow; Be regulating menstruation like some but can not treat dysmenorrhea; Some is treated inflammation but can not treat leukorrheal diseases etc., and present treatment by Chinese herbs, and dose is big, the therapeutic effect problem of unstable, so therapeutic effect is also satisfied people's will not to the utmost.
Summary of the invention
The present invention overcomes the defective of above-mentioned existence, the pharmaceutical composition of the treatment gynaecopathia that purpose is that a kind of good effect, short treating period are provided, dose is little, expense is low, have no side effect, take safety, therapeutic domain is wider.Medicine of the present invention has been given full play to the synergistic magical curative effect of Chinese medicine, in the performance to the symptom of various gynecological diseases clinically and patient's sign, has summed up pharmaceutical composition of the present invention, controls to mend and lays equal stress on, and in treatment, has the effect of blood yiqi concurrently.
The characteristics that the present invention treats the medicine of gynaecopathia are that said medicine is the medicament of being processed by following each raw material of Chinese medicine by weight:
180~450 parts of 160~420 parts of Herba Fici Simplicissimae of 160~420 parts of Stigma Crocis of the Pseudobulbus Bletillae (Rhizoma Bletillae)
136~387 parts of 136~387 parts of Radix Achyranthis Bidentataes of 180~450 parts of Radix Gentianae of Herba Glechomae
136~387 parts of 136~387 parts of Olibanums of 136~387 parts of Herba Blumeae Balsamiferaes of Herba Scutellariae Barbatae
106~350 parts of 65~230 parts of Herba Taxillis of 80~230 parts of Radix calophylli membranacei of Radix Picriae felterrae
106~350 parts of 106~350 portions of Semen Plantaginiss of river wooden barrel
Medicine of the present invention can be formulated by following each raw material of Chinese medicine:
350 parts of 340 parts of Herba Fici Simplicissimae of 340 parts of Stigma Crocis of the Pseudobulbus Bletillae (Rhizoma Bletillae)
242 parts of 242 parts of Radix Achyranthis Bidentataes of 350 parts of Radix Gentianae of Herba Glechomae
242 parts of 242 parts of Olibanums of 242 parts of Herba Blumeae Balsamiferaes of Herba Scutellariae Barbatae
235 parts of 108 parts of Herba Taxillis of 120 parts of Radix calophylli membranacei of Radix Picriae felterrae
235 parts of 235 portions of Semen Plantaginiss of river wooden barrel
The process for preparing medicine that the present invention treats gynaecopathia may further comprise the steps:
1. get 340 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, be ground into Pseudobulbus Bletillae (Rhizoma Bletillae) powder;
2. with Stigma Croci, Herba Fici Simplicissimae, Herba Glechomae, Radix Gentianae, Radix Achyranthis Bidentatae, Herba Scutellariae Barbatae, Herba Blumeae Balsamiferae, Olibanum, Radix Picriae felterrae, Radix calophylli membranacei, Herba Taxilli, river wooden barrel, Semen Plantaginis totally 13 the flavor medicines add successively 10 times the amount and 8 times of water gagings decoct respectively once; Decocted 5 hours for the first time; Decocted 4 hours for the second time; Merge to decoct, filter, filtrating is evaporated to relative density under-0.075Mpa, 80 degrees celsius be 1.15~1.16 clear paste;
3. with step 1. in gained Pseudobulbus Bletillae (Rhizoma Bletillae) powder and step 2. middle gained the clear paste mixing, with a 0.075Mpa, 80 degrees centigrade condition drying under reduced pressure, pulverize medicated powder;
4. with step 3. in gained medicated powder and suitable adjuvant through granulation, tabletting, coating, tablet.
Above umber is parts by weight.
The traditional Chinese medical science thinks that the generation dominant mechanism of menoxenia is visceral dysfunction, disharmony between QI and blood, and the damage that causes dashing wantonly two arteries and veins, the Therapeutic Principle focuses on adjusting meridian and stopping leukorrhea to effect a permanent cure.Mostly the dysmenorrhea morbidity is qi depression to blood stasis, it is attacked by the cold and evil, and damp-heat accumulation, the anxious grade of vessels of the uterus contraction causes obstruction of the uterine collateral.Adnexitis, pelvic inflammatory disease, endometritis etc. be mostly that the place has retention of damp-heat in the interior, the multiple abscess part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, retardance QI and blood, alluvial to dash to appoint or puerperal in menstrual period surplus blood not to the greatest extent, experience damp and hot heresy, damp and hot and the blood knot of fighting is down to suffering from abdominal pain.Make a general survey of above-mentioned disease, though the symptom performance has nothing in common with each other, the etiology and pathogenesis of its morbidity has gone common part.
Treat in the Chinese medicine preparation that gynaecopathia puts in the present invention: Pseudobulbus Bletillae (Rhizoma Bletillae) meridian distribution of property and flavor, bitter, sweet, puckery, be slightly cold, return lung, liver, stomach warp, astringing to arrest bleeding, detumescence end flesh.Stigma Croci sweet in the mouth property is flat, blood circulation promoting and blood stasis dispelling, dissipating blood stasis relieving accumulation of pathogens, pain relieving.The Herba Fici Simplicissimae invigorating the spleen for eliminating dampness, regulating qi to disperse stagnation, relaxing muscles and tendons and activating QI and blood in the collateral.The Herba Glechomae cold nature, bitter in the mouth, little hardship, the heat-clearing and toxic substances removing dissipating blood stasis for subsidence of swelling, dampness removing is treating stranguria.The Radix Gentianae bitter in the mouth is returned liver, gallbladder meridian, controls swelling of the vulva pudendal pruritus, damp-heat vaginal discharge.Radix Achyranthis Bidentatae dissipating blood stasis blood, subduing inflammation.The hot temperature of Herba Blumeae Balsamiferae property, bitter in the mouth, expelling wind and removing dampness, promoting blood circulation to remove blood stasis, killing parasites for relieving itching, refreshmentization is turbid, Xin Xiang walks to scurry, inducting the medicines into affected channel.The river wooden barrel is ignited descending.Semen Plantaginis promoting diuresis to eliminate damp pathogen and Herba Scutellariae Barbatae, Radix Picriae felterrae, Radix calophylli membranacei, Herba Taxilli share clearing heat and expelling damp and leukorrhagia stopping.How through the gynaecopathia that internal organs imbalance of YIN and YANG due to wet, heat, cold, wind, the poison is caused of ruling together have clearing away heat-damp and promoting diuresis, dampness blood stasis dispelling, putrefaction removing removing toxic substances, nourishing the liver and kidney, strengthen the spleen and stomach, the function of warming YANG to expel cold.
With the above-mentioned raw materials medicament mixed together, process tablet, according to the rule of " identification of etiology according to differenciation of symptoms and signs "; With remedying defects and rectifying errors, equilibrium between yin and yang is criterion, on prescription, stresses " monarch, minister, help, make " reasonable compatibility medicine, each other to correct its bias; Eliminate or reduction toxicity; Increase curative effect, bring into play the comprehensive function of complementing each other or opposing each other and yet also complement each other between each medicine, make it extremely remarkable on wholistic therapy.
Compared with prior art, beneficial effect of the present invention is embodied in:
1, compatibility of the present invention rationally, select medicine to forbid, all medicines share, bring out the best in each other, effect is remarkable, play heat-clearing and toxic substances removing altogether, the effect of adjusting meridian and stopping leukorrhea.Starting with from conscience, spleen four dirty physiological characteristicies, is main with the treatment gynaecopathia, is aim with YIN and YANG balance regulating, strengthening vital QI to eliminate pathogenic factors, has possessed the effect of nourishing blood and promoting blood circulation, Yiqi and vein recovery, enriching yin and nourishing kidney.
2, preparation technology of the present invention makes medicine to be suitable for disease more; Short treating period has no side effect, and its curative effect is significantly improved; Greatly facilitate taking of patient, menoxenia, dysmenorrhea, adnexitis, pelvic inflammatory disease and endometritis, cervicitis, pruritus vulvae are had effect preferably.
Though present composition prescription is complicated; But be suitable for the various clinical symptom, control to mend and lay equal stress on, solved now a lot of medicine for gynecopathy and had only simple therapeutic purposes; So often the patient is dirty owing to medicine property of medicine fine horse damages other devices suddenly; The present invention carries out prescription according to traditional Chinese medical theory, and on consumption, carries out scientific matching, makes the present invention can play therapeutical effect and does not worry that again medicine can cause side effect.Simultaneously, modern pharmacological research and clinical research result show that determined curative effect of the present invention has no side effect.
The safety research test of pharmaceutical composition of the present invention:
1, studies on acute toxicity: healthy rat and mice single oral are respectively irritated the medicine that stomach gives treatment gynaecopathia of the present invention, tangible acute toxic reaction do not occur, also do not cause animal dead.Filling stomach dosage is 100 times of clinical plan consumption.Tangible acute toxic reaction does not appear in mice, and rat occurs having loose bowels just, reactions such as movable minimizing, and the acute toxicity target organ is liver and spleen.
2, six months toxicity tests of rat: continuous six months of rat per os is respectively treated the medicinal tablet of gynaecopathia, is respectively 200,100 and 50 times of clinical plan consumption.Any tangible toxicity all do not occur whole experimental session male and female rat, do not cause animal dead yet.Three dose groups to rat body weight increase, ingesting, drinking water does not all have obviously influence.It is a drug withdrawal inspection in month that about the 3rd month of mid-term of administration, about the 6th month of next day of drug withdrawal and convalescent period finish; Three dose groups do not have obvious influence to the organ weights and the coefficient in each stage, and answer is seen and any pathomorphology and Histological change are not all seen by histopathologic examination yet.
Above toxicologic study result indicates that the medicine of treatment gynaecopathia of the present invention has higher safety.
The present invention controls clinical trial to dialectical the executing that patients such as various common gynecological diseases such as menoxenia, dysmenorrhea, adnexitis, pelvic inflammatory disease have carried out traditional Chinese medical science typing, according to the clinical observation record:
Case 1, patient main suit: cause menoxenia because of putting intrauterine device, menstrual period are indefinite to protract the time, light coloured menses, and have soreness of the waist and knees, clear and thin leucorrhea, dizziness and tinnitus, mood confusing, do not like to contact with the people.Treatment: the medicinal tablet of oral above-mentioned treatment gynaecopathia, day clothes 3 times, a 5g, 20 days is a course of treatment.Soreness of the waist and knees, dizziness and tinnitus obviously alleviate after taking medicine four, five days.Take medicine menstrual cycle rule after two courses of treatment, through blood red, passed through in every month 6 days promptly clean, malaise symptoms all disappears, recovery from illness.Follow up a case by regular visits to not recurrence.
Case 2, patient main suit: suffer from chronic pelvic inflammatory disease.Treatment: the medicinal tablet of oral above-mentioned treatment gynaecopathia, day clothes 3 times, a 5g, 20 days is a course of treatment, and after taking medicine four days leucorrhea obviously reduces, and lower abdomen is not bitterly.Taking medicine, all senses of discomfort help digestion after two courses of treatment, recovery from illness.Follow up a case by regular visits to not recurrence.
Case 3, patient main suit: external genital often has pruritus, leucorrhoea grow in quantity, and leucorrhea is a lark, and sexual life has pain.Gynecological's test under microscope is confirmed as trichomonal vaginitis, and is positive.Treatment: the medicinal tablet of oral above-mentioned treatment gynaecopathia, day clothes 3 times, a 5g, 20 days is a course of treatment.Pruritus vulvae is controlled after taking medicine two days, and leucorrhea obviously reduces after seven days, after the course of treatment of taking medicine leucorrhea inspection negative, all senses of discomfort disappear, recovery from illness.
Case 4, patient main suit: chronic pelvic inflammatory disease, behind western medical treatment, recur, showing as leucorrhea increases, and sacrum portion pain, especially intermenstrual period and the sexual life postemphasis of lower abdomen and waist often can not played spirit, headache, insomnia, weak, can not work contentedly.Treatment: the tablet of oral above-mentioned treatment gynaecopathia, day clothes 3 times, a 5g, 20 days is a course of treatment.After taking medicine 5 days leucorrhea obviously reduces, and general malaise sx, lower abdomen are not bitterly.Taking medicine, all senses of discomfort disappear after two courses of treatment, recovery from illness.Follow up a case by regular visits to not recurrence.
The specific embodiment
Below in conjunction with specific embodiment the present invention is done further replenishing, but do not limit the present invention in any way.The present embodiment batching is:
350 parts of 340 parts of Herba Fici Simplicissimae of 340 parts of Stigma Crocis of the Pseudobulbus Bletillae (Rhizoma Bletillae)
242 parts of 242 parts of Radix Achyranthis Bidentataes of 350 parts of Radix Gentianae of Herba Glechomae
242 parts of 242 parts of Olibanums of 242 parts of Herba Blumeae Balsamiferaes of Herba Scutellariae Barbatae
235 parts of 108 parts of Herba Taxillis of 120 parts of Radix calophylli membranacei of Radix Picriae felterrae
235 parts of 235 portions of Semen Plantaginiss of river wooden barrel
Concrete preparation operation as follows:
1. get 340 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, be ground into Pseudobulbus Bletillae (Rhizoma Bletillae) powder;
2. with Stigma Croci, Herba Fici Simplicissimae, Herba Glechomae, Radix Gentianae, Radix Achyranthis Bidentatae, Herba Scutellariae Barbatae, Herba Blumeae Balsamiferae, Olibanum, Radix Picriae felterrae, Radix calophylli membranacei, Herba Taxilli, river wooden barrel, Semen Plantaginis totally 13 the flavor medicines add successively 10 times the amount and 8 times of water gagings decoct respectively once; Decocted 5 hours for the first time; Decocted 4 hours for the second time; Merge to decoct, filter, filtrating is evaporated to relative density under-0.075Mpa, 80 degrees celsius be 1.15~1.16 clear paste;
3. with step 1. in gained Pseudobulbus Bletillae (Rhizoma Bletillae) powder and step 2. middle gained the clear paste mixing, with-0.075Mpa, 80 degrees centigrade condition drying under reduced pressure, pulverize medicated powder;
4. with step 3. in gained medicated powder and suitable adjuvant through granulation, tabletting, coating, tablet.
Be suitable for disease: be used to treat menoxenia, dysmenorrhea, vaginitis, adnexitis, pelvic inflammatory disease and endometritis etc. due to the damp-heat accumulation.
Consumption: three times on the one, a 5g took this medicament 15g altogether on the 1st.
Claims (4)
1. medicine of treating gynaecopathia is characterized in that it is the medicament of being processed by the medical material of following weight proportioning:
180~450 parts of 160~420 parts of Herba Fici Simplicissimae of 160~420 parts of Stigma Crocis of the Pseudobulbus Bletillae (Rhizoma Bletillae)
136~387 parts of 136~387 parts of Radix Achyranthis Bidentataes of 180~450 parts of Radix Gentianae of Herba Glechomae
136~387 parts of 136~387 parts of Olibanums of 136~387 parts of Herba Blumeae Balsamiferaes of Herba Scutellariae Barbatae
106~350 parts of 65~230 parts of Herba Taxillis of 80~230 parts of Radix calophylli membranacei of Radix Picriae felterrae
106~350 parts of 106~350 portions of Semen Plantaginiss of Caulis Clematidis Armandii
2. a kind of medicine of treating gynaecopathia according to claim 1 is characterized in that this medicine is to be processed by the raw material of following weight portion:
350 parts of 340 parts of Herba Fici Simplicissimae of 340 parts of Stigma Crocis of the Pseudobulbus Bletillae (Rhizoma Bletillae)
242 parts of 242 parts of Radix Achyranthis Bidentataes of 350 parts of Radix Gentianae of Herba Glechomae
242 parts of 242 parts of Olibanums of 242 parts of Herba Blumeae Balsamiferaes of Herba Scutellariae Barbatae
235 parts of 108 parts of Herba Taxillis of 120 parts of Radix calophylli membranacei of Radix Picriae felterrae
235 parts of 235 portions of Semen Plantaginiss of Caulis Clematidis Armandii
3. the method for preparing of a treatment medicine for gynecopathy as claimed in claim 2 is characterized in that operating as follows:
1. get 340 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, be ground into Pseudobulbus Bletillae (Rhizoma Bletillae) powder;
2. with Stigma Croci, Herba Fici Simplicissimae, Herba Glechomae, Radix Gentianae, Radix Achyranthis Bidentatae, Herba Scutellariae Barbatae, Herba Blumeae Balsamiferae, Olibanum, Radix Picriae felterrae, Radix calophylli membranacei, Herba Taxilli, Caulis Clematidis Armandii, Semen Plantaginis totally 13 the flavor medicines add successively 10 times the amount and 8 times of water gagings decoct respectively once; Decocted 5 hours for the first time; Decocted 4 hours for the second time; Merge to decoct, filter, filtrating is evaporated to relative density under-0.075Mpa, 80 degrees celsius be 1.15~1.16 clear paste;
3. with step 1. in gained Pseudobulbus Bletillae (Rhizoma Bletillae) powder and step 2. middle gained the clear paste mixing, with-0.075Mpa, 80 degrees centigrade condition drying under reduced pressure, pulverize medicated powder;
4. with step 3. in gained medicated powder and suitable adjuvant through granulation, tabletting, coating, tablet.
4. a kind of method for preparing of treating medicine for gynecopathy according to claim 3 is characterized in that: can manufacture tablet, capsule, granule or pill by the pharmaceutics processing method.
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CN103301353B (en) * | 2013-07-01 | 2015-03-11 | 刘晓晖 | Pharmaceutical composition for treating atrophic vaginitis |
CN103301354B (en) * | 2013-07-01 | 2015-03-04 | 王莉莉 | Preparation method of powder for treating infantile vaginitis |
CN108686132A (en) * | 2018-08-27 | 2018-10-23 | 韦幸艺 | A kind of Chinese herbal medicine formula for treating gynaecological disease |
CN113274458A (en) * | 2021-06-11 | 2021-08-20 | 田纪红 | Medicine for treating gynecopathy |
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CN1634319A (en) * | 2004-10-18 | 2005-07-06 | 广西梧州制药(集团)股份有限公司 | Chinese traditional medicine compound preparation for treating gynecopathy and preparation method thereof |
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CN101879294B (en) * | 2010-06-29 | 2012-05-09 | 刘性祥 | Chinese medicinal composition for treating uterus cold |
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张奎军等.慢性前列腺炎中医治疗进展.《辽宁中医杂志》.2005,(第01期), * |
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