CN101884770A - Chinese medicinal preparation for treating urolithiasis and preparation method thereof - Google Patents
Chinese medicinal preparation for treating urolithiasis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal preparation for treating urolithiasis, which is prepared from niter, chicken's gizzard-membrane, alum, gardenia jasminoides, Japanese climbing fern spore, longhairy antenoron herb, cluster mallow fruit, herba pyrrosiae, virgate wormwood herb, amber, cuttlebone, pangolin scales, cowherb seed, spreading hedyotis herb, frankincense, myrrh, white paeony root, lalang grass rhizome, clematis root, corydalis root, radix curcumae, talc, pink herb, medicinal cyathula root, giant knotweed rhizome, astragalus, mongolian dandelion herb, mole cricket, plantain seed, herba polygoni avicularis, yellow croaker ear-stone, common burreed rhizome, zedoary, gleditsia thorn, dried orange peel, ephedra, oriental waterplantain rhizome, chinese waxgourd peel, notoginseng root, agaric, Chinese eaglewood, akebia stem, rhubarb and India madder root in a certain weight ratio. The Chinese medicinal preparation can be prepared into any common oral administration formulation. In a formula of the Chinese medicinal preparation, the medicaments have the good synergistic effect on the curative effect through reasonable compatibility, so the effects of inducing diuresis, treating stranguria and removing urinary calculus are achieved better, and the symptoms are removed. Compared with the prior art, the Chinese medicinal preparation has the advantages of quick response, high cure rate, relapse prevention, no toxic or side effect, low treatment cost and easy acceptance by patients.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine preparation for the treatment of urinary calculus and preparation method thereof.
Background technology
Urinary calculus is the Iithiasic general name in each position of urinary system, is the commonly encountered diseases of urinary system.According to the difference at position, calculus place, be divided into renal calculus, ureteral calculus, vesical calculus, calculus of urethra.The formation of primary disease and environmental factors, general pathological changes and diseases of urinary system have substantial connection.Its typical clinical shows visible waist angina abdominis, hematuria, or the symptom of blocking and infecting with urinary systems such as frequent micturition, urgent micturition, dysureas.The urinary calculus healthhazard mainly shows the local damage of calculus to urinary tract, and calculus causes urinary tract obstruction and concurrent urinary tract infection.Little calculus can move in urinary tract, and the urinary tract mucosa that frays easily causes bleeding, renal colic.The huge gallstone of bigger fixed Cornu Cervi type though pain is not severe, can be oppressed urinary tract mucosa for a long time, makes epithelial damage, tissue ulcer, so that calculus and ureter tube wall form adhesion, serious also may cause renal function depletion.At present, treating this disease has three kinds of methods: 1) operative treatment, and this method is bigger to patient's wound, and the relapse rate height, and the patient does not adopt this method treatment mostly.2) external stone crushing, the medical expense height, lithotrity effect is also not ideal sometimes, and relapse rate is up to more than 30%.3) treatment by Chinese herbs, expense is low, it is little that the patient is damaged, and mostly adopts this method treatment.But this sick Chinese medicine preparation of state's internal therapy all can not reach ideal therapeutic effect.
Summary of the invention
So still there is demand in the Chinese medicine preparation that the mankind better treat urinary calculus to curative effect, up to now, also do not find the report of any relevant pharmaceutical composition of the present invention, the inventor studies repeatedly through a large amount of clinical practices, finally find the Chinese medicine preparation of the treatment urinary calculus of better efficacy, finished the present invention.The object of the invention provides little, the treating both the principal and secondary aspects of a disease of a kind of side effect, can more effectively treat the Chinese medicine preparation of first and recurrent urinary calculus.Another object of the present invention has been to provide the preparation method of this Chinese medicine preparation.
The consumption of drug component of the present invention is that inventor's process gropes to sum up to get for a long time in a large number, and each amounts of components all has curative effect preferably in the following weight parts scope: 5～7 parts on Sal Nitri, 2～4 parts of Endothelium Corneum Gigeriae Galli, 5～7 parts of Alumens, 1～3 part of Fructus Gardeniae, 2～4 parts of Spora Lygodii, 5～7 parts of Herba Lysimachiaes, 3～5 parts of Semen Abutilis, 4～6 parts of Folium Pyrrosiae, 4～6 parts of Herba Artemisiae Scopariaes, 1～2 part of succinum, 2～3 parts of Endoconcha Sepiaes, 0.5～1.5 part of Squama Manis, 3～5 parts of Semen Vaccariae, 4～5 parts of Herba Hedyotidis Diffusaes, 0.5～1.5 part of Olibanum, 0.5～1.5 part of Myrrha, 3～5 parts of the Radix Paeoniae Albas, 5～7 parts of Rhizoma Imperataes, 5～7 parts of Radix Clematidis, 1～3 part of Rhizoma Corydalis, 3～5 parts of Radix Curcumaes, 3～5 parts in Talcum, 4～6 parts of Herba Dianthis, 3～5 parts of Radix Cyathulaes, 3～5 parts of Rhizoma Polygoni Cuspidati, 4～6 parts of the Radixs Astragali, 3～5 parts of Herba Taraxacis, 3～5 parts of Gryllotalpas, 4～6 parts of Semen Plantaginiss, 3～5 parts of Herba Polygoni Avicularis, 1～3 part of Asteriscus Pseudosciaenae, 0.5～1.5 part of rhizoma sparganic, 0.5～1.5 part of Rhizoma Curcumae, 2～3 parts of Spina Gleditsiae, 3～5 parts of Pericarpium Citri Reticulataes, 1～2 part in Herba Ephedrae, 3～4 parts of Rhizoma Alismatis, 3～4 parts of Exocarpium Benincasaes, 0.5～1.5 part of Radix Notoginseng, 3～5 parts of Polyporus, 0.2～0.8 part of Lignum Aquilariae Resinatum, 0.5～1.5 part of Caulis Akebiae, 0.5～1.5 part of Radix Et Rhizoma Rhei, 2～3 parts in Radix Rubiae.
Be preferably: 5 parts on Sal Nitri, 4 parts of Endothelium Corneum Gigeriae Galli, 5 parts of Alumens, 2 parts of Fructus Gardeniaes, 4 parts of Spora Lygodii, 5 parts of Herba Lysimachiaes, 3 parts of Semen Abutilis, 4 parts of Folium Pyrrosiae, 4 parts of Herba Artemisiae Scopariaes, 1.5 parts of succinums, 2 parts of Endoconcha Sepiaes, 1 part of Squama Manis, 3 parts of Semen Vaccariae, 4 parts of Herba Hedyotidis Diffusaes, 1 part of Olibanum, 1 part of Myrrha, 3 parts of the Radix Paeoniae Albas, 5 parts of Rhizoma Imperataes, 5 parts of Radix Clematidis, 2 parts of Rhizoma Corydalis, 3 parts of Radix Curcumaes, 3 parts in Talcum, 4 parts of Herba Dianthis, 3 parts of Radix Cyathulaes, 3 parts of Rhizoma Polygoni Cuspidati, 4 parts of the Radixs Astragali, 5 parts of Herba Taraxacis, 3 parts of Gryllotalpas, 5 parts of Semen Plantaginiss, 5 parts of Herba Polygoni Avicularis, 3 parts of Asteriscus Pseudosciaenaes, 1 part of rhizoma sparganic, 1 part of Rhizoma Curcumae, 2 parts of Spina Gleditsiae, 3 parts of Pericarpium Citri Reticulataes, 1 part in Herba Ephedrae, 4 parts of Rhizoma Alismatis, 3 parts of Exocarpium Benincasaes, 1 part of Radix Notoginseng, 3 parts of Polyporus, 0.5 part of Lignum Aquilariae Resinatum, 1 part of Caulis Akebiae, 1 part of Radix Et Rhizoma Rhei, 2 parts in Radix Rubiae.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any routine dosage form for oral administration.
Preferably, the preparation method of medicine of the present invention is as follows:
After described materials of weight proportions medicine Squama Manis, Olibanum, Myrrha, Rhizoma Corydalis concocted with conventional method, standby; With described materials of weight proportions medicine Sal Nitri, Endothelium Corneum Gigeriae Galli, Alumen, Fructus Gardeniae, Spora Lygodii, Herba Lysimachiae, Semen Abutili, Folium Pyrrosiae, Herba Artemisiae Scopariae, succinum, Endoconcha Sepiae, Semen Vaccariae, Herba Hedyotidis Diffusae, the Radix Paeoniae Alba, Rhizoma Imperatae, Radix Clematidis, Radix Curcumae, Talcum, Herba Dianthi, Radix Cyathulae, Rhizoma Polygoni Cuspidati, the Radix Astragali, Herba Taraxaci, Gryllotalpa, Semen Plantaginis, Herba Polygoni Avicularis, Asteriscus Pseudosciaenae, rhizoma sparganic, Rhizoma Curcumae, Spina Gleditsiae, Pericarpium Citri Reticulatae, Herba Ephedrae, Rhizoma Alismatis, Exocarpium Benincasae, Radix Notoginseng, Polyporus, Lignum Aquilariae Resinatum, Caulis Akebiae, Radix Et Rhizoma Rhei, the Squama Manis of Radix Rubiae after the back and the process of preparing Chinese medicine are handled in cleaning, Olibanum, Myrrha, Rhizoma Corydalis mixes, grind, cross 80 mesh sieves, get fine powder, sterilization incapsulates and gets final product.
Medicament selection Sal Nitri of the present invention, Endothelium Corneum Gigeriae Galli, Alumen, Fructus Gardeniae, Spora Lygodii, Herba Lysimachiae, Semen Abutili, Folium Pyrrosiae, Herba Artemisiae Scopariae, succinum, Endoconcha Sepiae, Squama Manis, Semen Vaccariae, Herba Hedyotidis Diffusae, Olibanum, Myrrha, the Radix Paeoniae Alba, Rhizoma Imperatae, Radix Clematidis, Rhizoma Corydalis, Radix Curcumae, Talcum, Herba Dianthi, Radix Cyathulae, Rhizoma Polygoni Cuspidati, the Radix Astragali, Herba Taraxaci, Gryllotalpa, Semen Plantaginis, Herba Polygoni Avicularis, Asteriscus Pseudosciaenae, rhizoma sparganic, Rhizoma Curcumae, Spina Gleditsiae, Pericarpium Citri Reticulatae, Herba Ephedrae, Rhizoma Alismatis, Exocarpium Benincasae, Radix Notoginseng, Polyporus, Lignum Aquilariae Resinatum, Caulis Akebiae, Radix Et Rhizoma Rhei and Radix Rubiae make up; Make each efficacy of drugs produce synergism these drug regimens, thereby better reach inducing diuresis for treating stranguria syndrome urinary calculus removing effect.
In the present invention, each crude drug function is as follows:
Sal Nitri: have another name called Sal Nitri, [property of medicine] is bitter, salty, and is cold.Return spleen, stomach, liver, kidney, large intestine channel.Anticancer, clearing away summer-heat eliminating stagnation, antiinflammatory detumescent relieve internal heat.
Endothelium Corneum Gigeriae Galli: [property hide return through] is sweet, and be cold.Return spleen, stomach, small intestinal, urinary bladder channel.[effect] promoting digestion and invigorating the stomach, arresting seminal emission; Energy is part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels damp-heat in the urinary bladder clearly, and the merit for the treatment of stranguria fossil is arranged, and is one of Iithiasic choice drug of clinical treatment.
Alumen: sour-puckery flavor cold in nature, return lung, liver, spleen, stomach, large intestine channel has stronger astriction.In recent years studies confirm that Alumen has antibiotic, effects such as anti-trichomonas vaginitis.The traditional Chinese medical science is mainly used in hemostasis antidiarrheal, the detoxifcation parasite killing; Treat damp and hot jaundice that causes and stranguria caused by urinary stone specially good effect is arranged.
The Fructus Gardeniae effect is that the pathogenic fire purging relieving restlessness is arranged, clearing away heat-damp and promoting diuresis, the effect of removing pathogenic heat from blood and toxic substance from the body, significant feature is that to be used for calentura vexed, gloomy, dry disturb not peaceful, jaundice, calculus due to the dampness-heat in the liver and gallbladder pent-up, the haematemesis of bleeding due to blood-heat, knob blood, hematuria etc.
Spora Lygodii: nature and flavor: cold in nature, sweet in the mouth.Return bladder, small intestine meridian.Eliminating damp-heat, treating stranguria pain relieving.Be used for pyretic stranguria, sand Stranguria, stranguria with blood, stranguria marked by chyluria, Urethra astringent pain.
Herba Lysimachiae has heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, and the effect of dampness removing jaundice eliminating can be used for pyretic stranguria, and husky the pouring urinated and puckeryly had a pain jaundice dark coloured urine, carbuncle furuncle, venom, liver and bile stone, diseases such as lithangiuria.Also have calculus, antibacterial, antiinflammatory action all has inhibitory action to humoral immunization, cellular immunization; According to the study, Herba Lysimachiae has the promotion ureteral peristalsis, increases the urine flow, reduces urine calcium, urate excretion, effectively suppresses the effect that calcium oxalate stone forms.
Semen Abutili is sweet cold sliding sharp, can relieving stranguria by diuresis, again can stimulating milk secretion, intestine moistening, and difficulty in urination and defecation person is all suitable.Be one of clinical treatment calculus of lower urinary tract common drug.
Folium Pyrrosiae, relieving stranguria by diuresis, lung heat clearing expels the heat-evil.Control and drench pain, hematuria, lithangiuria, nephritis, metrorrhagia, dysentery, cough due to lung-heat, chronic tracheitis, incised wound, carbuncle.
Herba Artemisiae Scopariae: nature and flavor cold nature, acrid in the mouth, hardship.Function cures mainly clearing away damp-heat, the jaundice eliminating subcutaneous ulcer.Be used for jaundice oliguria, eczema pruritus, infectious jaundice type hepatitis, cholelithiasis etc.
Succinum [meridian distribution of property and flavor] is sweet, and is flat, [function cures mainly] calmness, and diuresis is invigorated blood circulation.Be used for infantile convulsion, epilepsy, cardiopalmus, insomnia, dysuria, dysurea, hematuria, amenorrhea, stranguria caused by urinary stone etc.
The effect dehumidifying of Endoconcha Sepiae, antacid, skin ulcer is held back in hemostasis.The acid regurgitation that treats for stomachache is told, nosebleed, hematemesis, has blood in stool, and bleeding not during menses, amenorrhea due to blood depletion, the stomachache lump in the abdomen, the intermittent fever of deficiency type dysentery, skin ulcer is rotted in the erosion of the vulva; All diseases due to the kind clear damp-heat in lower-JIAO.
Squama Manis nature and flavor salty in the mouth; The cold nature function cures mainly: blood circulation promoting and dispersing pathogen accumulation; The stimulating milk secretion of stimulating the menstrual flow; Eliminating carbuncle is burst hard.Main blood stasis amenorrhea; Lump in the abdomen; Rheumatic arthralgia; Agalactia; Carbuncle, scrofula, the reaction of eliminating or reduce inflammation alleviates tissue edema or cicatrix.
Semen Vaccariae: meridian distribution of property and flavor] hardship, flat.Return liver, the stomach warp.[effect] promoting blood circulation to restore menstrual flow, stimulating milk secretion eliminating carbuncle, inducing diuresis for treating stranguria syndrome.Compendium of Material Medica is loaded with logical plug effect, and it is satisfied to be used to infraction property curative effect of disease.
Herba Hedyotidis Diffusae: return through, the heart; Liver; Spleen; Large intestine channel; Function cures mainly: heat-clearing and toxic substances removing; Dampness removing.Main dyspnea and cough due to lung-heat; Laryngopharynx swelling and pain; The intestinal carbuncle; The furuncle and phyma skin infection; Venom; The puckery pain of pyretic stranguria; Edema; Dysentery; The intestinal inflammation; Jaundice due to damp-heat; Cancerous protuberance.
Olibanum: arduous, temperature.Cure mainly: regulating qi and activating blood, analgesic therapy chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.
Myrrha; [effect]: the blood blood stasis removing that looses, subduing swelling and relieving pain
The Radix Paeoniae Alba, picric acid, cold.[function cures mainly] nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia; The relieve muscle spasms effect is arranged.
Rhizoma Imperatae [meridian distribution of property and flavor] is hot, bitter, and is cold.Return liver, the heart, lung meridian.[function cures mainly] regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.Be used for the amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, the calentura coma, epilepsy is gone mad, the jaundice dark coloured urine; Reach diseases such as sand Stranguria, stranguria caused by urinary stone, stranguria with blood.
Radix Curcumae [nature and flavor] is arduous, cold.[function cures mainly] promoting QI circulation for relieving depression, the removing heat from blood removing blood stasis with potent drugs.Be one of cholagogic and lithagogue common drug.
Talcum, [nature and flavor with return through] are sweet, light, and are cold.Return bladder, lung, stomach warp.[function with cure mainly] inducing diuresis for treating stranguria syndrome, clearing away summer-heat, skin ulcer is held back in damp eliminating.Be used for pyretic stranguria, stranguria caused by urinary stone is urinated hot puckery pain, heat-damp in summer excessive thirst, damp and hot watery diarrhea; External treatment eczema, eczema, miliaria.Be used for diseases such as dysuria, the puckery pain of pouring drop, can join product such as Semen Plantaginis, Caulis Akebiae; Be used for the damp and hot watery diarrhea that causes, can cooperate Poria, Semen Coicis, Semen Plantaginis to be equal to usefulness.
Herba Dianthi [performance] hardship, cold.GUIXIN, small intestine meridian.[effect] inducing diuresis for treating stranguria syndrome, removing blood stasis stimulates the menstrual flow, the clinical disease that is mainly used in the treatment dysuria, drenches puckery pain of drop and blood stasis amenorrhea.
Radix Cyathulae, nature and flavor with return through, sweet, little hardship, flat.Return liver, kidney channel.Function with cure mainly eliminating blood stasis and inducing menstruation, easing joint movement, inducing diuresis for treating stranguria syndrome.Be used for the amenorrhea lump in the abdomen, retention of placenta, arthralgia, flaccidity of the lower limbs clonic spasm of the muscle, hematuria stranguria with blood, injury from falling down.
The little hardship of Rhizoma Polygoni Cuspidati [nature and flavor with return through] is slightly cold.Return liver, gallbladder, lung meridian.[function with cure mainly] heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.Be used for arthralgia, jaundice due to damp-heat, amenorrhea ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus.
The Radix Astragali has effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting.
The Herba Taraxaci bitter but sweet flavor is cold in nature, returns liver, kidney channel, energy heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, the merit of dampness removing 3 pouring.
Gryllotalpa [meridian distribution of property and flavor] is salty, and is cold.Slightly poisonous.Return bladder, large intestine, small intestine meridian.[function cures mainly] diuretic, relieving constipation.It is swollen to harness the river, stranguria caused by urinary stone, dysuria, scrofula, carbuncle malignant boil.
The Semen Plantaginis nature and flavor are sweet; Light; Cold nature.Gui Jing: return lung; Liver; Kidney; Urinary bladder channel.Function cures mainly: clearing away heat and promoting diuresis; Eliminating dampness by diuresis antidiarrheal; Make eye bright; Eliminate the phlegm.Main dysuria; The stranguria with turbid discharge leukorrhagia; The edema distension; The heat-damp in summer dysentery; Conjunctival congestion is hidden from view; The expectorant heat syndrome cough is breathed heavily.
The Herba Polygoni Avicularis hardship is slightly cold.Return urinary bladder channel.This product hardship is fallen row, the tonneau bladder, bitter dry again can the parasite killing removing damp to relieve itching, be mainly used in and drench pain and eczema.
Asteriscus Pseudosciaenae [nature and flavor] " the medical center bun is wanted ": " salty, flat." [function cures mainly] fossil, treating stranguria, antiinflammatory.Control stranguria caused by urinary stone, dysuria, otitis media, rhinitis, sinusitis with purulent discharge.
Rhizoma sparganic [meridian distribution of property and flavor] is hot, bitter, and is flat.Return liver, spleen channel.The circulation of qi promoting of [function cures mainly] removing blood stasis, the removing food stagnancy pain relieving.Be used for the lump in the abdomen mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain.
Rhizoma Curcumae [meridian distribution of property and flavor] is hot, bitter, temperature.Return liver, spleen channel.Effect cures mainly, and 1) the removing blood stasis promoting the circulation of QI to relieve pain.
2) long-pending eliminating stagnation: this product can the pain relieving of circulation of qi promoting removing food stagnancy, is used for eating accumulation, the breast abdominal distention is vexed has a pain.3) removing blood stasis, women's amenorrhea, or the phlegm-damp congestion lump in the abdomen addiction piece that condenses and form.4) promoting the circulation of QI to relieve pain: be suitable for drinking and eating irregularly, the card of gastral cavity abdomen overflow pain.Suitable compatibility, deficient syndrome, the case of a physically strong patient running a high fever all can.
Spina Gleditsiae nature and flavor and function suffering, temperature.Return liver, stomach warp, the evacuation of pus of drawing out pus by applying a plaster to the affected part, promoting blood circulation and detumescence.Be used for carbuncle, sore, pus do not become to burst scabies.Be tcm clinical practice fossil medicine commonly used.
Pericarpium Citri Reticulatae: meridian distribution of property and flavor temperature; Hot, bitter; Return spleen, lung meridian function to cure mainly, regulating qi-flowing for strengthening spleen, in the accent, dampness is reduced phlegm.Cure mainly the distension and fullness in the abdomen of stagnation of QI in spleen and stomach or pain, dyspepsia.Abdominal distention uncomfortable in chest, indigestion and loss of appetite loose stool in the turbid damp resistance.Phlegm-damp is stopped up the cough and asthma of lung.
Herba Ephedrae, [nature and flavor with return through] are hot, little hardship, temperature.Return lung, urinary bladder channel.[function with cure mainly] diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.
The Rhizoma Alismatis nature and flavor are sweet; Light; Cold in nature, function cures mainly, promoting diuresis to eliminate damp pathogen; It is treating stranguria to expel the heat-evil.Main dysuria; The puckery pain of pyretic stranguria; The edema distension; Have loose bowels; Dizziness due to fluid-retention; Seminal emission.Studies have shown that: Rhizoma Alismatis suppresses calcium oxalate crystal growth and cohesion, reduces formation, the precipitation of calcium oxalate crystal in the renal tubules, suppresses the formation of renal calculus.
Exocarpium Benincasae, nature and flavor are cool in nature, sweet in the mouth.Function cures mainly, inducing diuresis to remove edema.Be used for edema distension, dysuria, thirsty, the oliguria with reddish urine of administration's heat.
Radix Notoginseng, nature and flavor: warm in nature, sweet in the mouth, little hardship.Function cures mainly: dissipating blood stasis hemostasis, subduing swelling and relieving pain.Be used for various inside and outside hemorrhage, breast ventral spine pain, tumbling and swelling.
Polyporus sweet in the mouth, light, flat, return kidney, urinary bladder channel.Promoting diuresis to eliminate damp pathogen.Control dysuria, edema, have loose bowels stranguria with turbid discharge, leukorrhagia.
The Lignum Aquilariae Resinatum meridian distribution of property and flavor, arduous, temperature.[effect] sending down the abnormal ascending QI warming middle-JIAO, the warming the kidney improving inspiration by invigorating kidney-QI.
Caulis Akebiae, [effect]: pathogenic fire purging row water.Promoting blood circulation.[curing mainly]: control hot urination, stranguria with turbid discharge, edema, irritable feverish sensation in the chest, sore throat pharyngalgia, inflexible pain all over, women's amenorrhea, galactostasis.
Radix Et Rhizoma Rhei has attacks effects such as stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, detoxifcation calculus.
Radix Rubiae has the effect of cooling blood for hemostasis, blood circulation promoting and blood stasis dispelling.Cure mainly diseases such as heat in blood spitting of blood, postpartum stagnation stomachache, traumatic injury, rheumatic arthralgia.
Urinary calculus is to occur in a kind of pathologic mineralising in the human body, calculus mainly is made up of mineral crystal and substrate two parts, crystalline solid supersaturation and substrate allosteric are the main prerequisite that forms calculus in the urine, the formation of its calculus is along with crystalline component (or claiming into the stone factor) in the urine changes and the dynamic process of variation with degraded, crystallised component and/or saturation during if the people for a change urinates, change over the stone condition, just can stop and reverse the pathology mineralization process, and then prevent that calculus from forming and promoting to have formed the dissolving and the discharge of calculus, Sal Nitri, Alumen, succinum, Talcum, natural mineral such as Asteriscus Pseudosciaenae directly change crystalline component and physicochemical property in the urine, Squama Manis, Olibanum, Myrrha, Rhizoma Corydalis, rhizoma sparganic, Rhizoma Curcumae etc. are eliminated lithogenous local infection, inflammation, unfavorable factors such as cicatrix, Spora Lygodii, Herba Lysimachiae, Herba Dianthi, clearing away heat-damp and promoting diuresis such as Herba Taraxaci are treating stranguria, Radix Clematidis, Rhizoma Alismatis, Polyporus etc. are alleviated smooth muscle and sphincterismus, diuresis and expelling stone.All medicines are collaborative to improve glomerular filtration rate, suppresses saline crystallization formation and cohesion, reduces crystalline component concentration coefficient in the urine, promotes litholysis and discharge, and can prevent the formation of calculus.
Prescription of the present invention is the reasonable compatibility by above all medicines, makes each herbal medicine produce good synergism on curative effect, thereby better reaches inducing diuresis for treating stranguria syndrome urinary calculus removing effect, makes calculus be dissolved discharge.Compared with prior art, the present invention has instant effect, cure rate height, is difficult for recurrence, has no side effect the low acceptable advantage of patient of treatment cost.
The specific embodiment
With following embodiment the present invention is described, but the present invention is not subjected to the restriction of these embodiment, the crude drug among the embodiment is to calculate with weight g.
Embodiment one
Medicine of the present invention is made by following materials of weight proportions medicine: Sal Nitri 500g, Endothelium Corneum Gigeriae Galli 400g, Alumen 500g, Fructus Gardeniae 200g, Spora Lygodii 400g, Herba Lysimachiae 500g, Semen Abutili 300g, Folium Pyrrosiae 400g, Herba Artemisiae Scopariae 400g, succinum 150g, Endoconcha Sepiae 200g, Squama Manis 100g, Semen Vaccariae 300g, Herba Hedyotidis Diffusae 400g, Olibanum 100g, Myrrha 100g, Radix Paeoniae Alba 300g, Rhizoma Imperatae 500g, Radix Clematidis 500g, Rhizoma Corydalis 200g, Radix Curcumae 300g, Talcum 300g, Herba Dianthi 400g, Radix Cyathulae 300g, Rhizoma Polygoni Cuspidati 300g, Radix Astragali 400g, Herba Taraxaci 500g, Gryllotalpa 300g, Semen Plantaginis 500g, Herba Polygoni Avicularis 500g, Asteriscus Pseudosciaenae 300g, rhizoma sparganic 100g, Rhizoma Curcumae 100g, Spina Gleditsiae 200g, Pericarpium Citri Reticulatae 300g, Herba Ephedrae 100g, Rhizoma Alismatis 400g, Exocarpium Benincasae 300g, Radix Notoginseng 100g, Polyporus 300g, Lignum Aquilariae Resinatum 50g, Caulis Akebiae 100g, Radix Et Rhizoma Rhei 100g, Radix Rubiae 200g.
Embodiment two:
Medicine of the present invention is made by following materials of weight proportions medicine: Sal Nitri 600g, Endothelium Corneum Gigeriae Galli 300g, Alumen 700g, Fructus Gardeniae 200g, Spora Lygodii 300g, Herba Lysimachiae 700g, Semen Abutili 400g, Folium Pyrrosiae 500g, Herba Artemisiae Scopariae 500g, succinum 150g, Endoconcha Sepiae 250g, Squama Manis 100g, Semen Vaccariae 400g, Herba Hedyotidis Diffusae 350g, Olibanum 100g, Myrrha 100g, Radix Paeoniae Alba 400g, Rhizoma Imperatae 700g, Radix Clematidis 700g, Rhizoma Corydalis 200g, Radix Curcumae 400g, Talcum 400g, Herba Dianthi 500g, Radix Cyathulae 400g, Rhizoma Polygoni Cuspidati 400g, Radix Astragali 500g, Herba Taraxaci 400g, Gryllotalpa 400g, Semen Plantaginis 500g, Herba Polygoni Avicularis 400g, Asteriscus Pseudosciaenae 200g, rhizoma sparganic 100g, Rhizoma Curcumae 100g, Spina Gleditsiae 250g, Pericarpium Citri Reticulatae 400g, Herba Ephedrae 150g, Rhizoma Alismatis 350g, Exocarpium Benincasae 350g, Radix Notoginseng 100g, Polyporus 400g, Lignum Aquilariae Resinatum 50g, Caulis Akebiae 100g, Radix Et Rhizoma Rhei 100g, Radix Rubiae 250g.
Embodiment three:
Medicine of the present invention is made by following materials of weight proportions medicine: Sal Nitri 700g, Endothelium Corneum Gigeriae Galli 400g, Alumen 700g, Fructus Gardeniae 300g, Spora Lygodii 400g, Herba Lysimachiae 700g, Semen Abutili 500g, Folium Pyrrosiae 600g, Herba Artemisiae Scopariae 600g, succinum 200g, Endoconcha Sepiae 300g, Squama Manis 150g, Semen Vaccariae 500g, Herba Hedyotidis Diffusae 500g, Olibanum 150g, Myrrha 150g, Radix Paeoniae Alba 500g, Rhizoma Imperatae 700g, Radix Clematidis 700g, Rhizoma Corydalis 300g, Radix Curcumae 500g, Talcum 500g, Herba Dianthi 600g, Radix Cyathulae 500g, Rhizoma Polygoni Cuspidati 500g, Radix Astragali 600g, Herba Taraxaci 500g, Gryllotalpa 500g, Semen Plantaginis 600g, Herba Polygoni Avicularis 500g, Asteriscus Pseudosciaenae 300g, rhizoma sparganic 150g, Rhizoma Curcumae 150g, Spina Gleditsiae 300g, Pericarpium Citri Reticulatae 500g, Herba Ephedrae 200g, Rhizoma Alismatis 400g, Exocarpium Benincasae 400g, Radix Notoginseng 150g, Polyporus 500g, Lignum Aquilariae Resinatum 80g, Caulis Akebiae 150g, Radix Et Rhizoma Rhei 150g, Radix Rubiae 300g.
The preparation method of medicine of the present invention is as follows:
After described materials of weight proportions medicine Squama Manis, Olibanum, Myrrha, Rhizoma Corydalis concocted with conventional method, standby; With described materials of weight proportions medicine Sal Nitri, Endothelium Corneum Gigeriae Galli, Alumen, Fructus Gardeniae, Spora Lygodii, Herba Lysimachiae, Semen Abutili, Folium Pyrrosiae, Herba Artemisiae Scopariae, succinum, Endoconcha Sepiae, Semen Vaccariae, Herba Hedyotidis Diffusae, the Radix Paeoniae Alba, Rhizoma Imperatae, Radix Clematidis, Radix Curcumae, Talcum, Herba Dianthi, Radix Cyathulae, Rhizoma Polygoni Cuspidati, the Radix Astragali, Herba Taraxaci, Gryllotalpa, Semen Plantaginis, Herba Polygoni Avicularis, Asteriscus Pseudosciaenae, rhizoma sparganic, Rhizoma Curcumae, Spina Gleditsiae, Pericarpium Citri Reticulatae, Herba Ephedrae, Rhizoma Alismatis, Exocarpium Benincasae, Radix Notoginseng, Polyporus, Lignum Aquilariae Resinatum, Caulis Akebiae, Radix Et Rhizoma Rhei, the Squama Manis of Radix Rubiae after the back and the process of preparing Chinese medicine are handled in cleaning, Olibanum, Myrrha, Rhizoma Corydalis mixes, grind, cross 80 mesh sieves, get fine powder, sterilization, incapsulate and get final product every heavy 0.5g of capsule.
Medicine of the present invention can be prepared into any peroral dosage form commonly used, as: pill, powder, tablet, capsule, oral agents etc.
The clinical observation of medicine of the present invention
To being reluctant or the urinary calculus patient of the ultrasonic external stone crushing of incompatibility treatment uses medicine of the present invention and carries out dissolution therapy and inquire into, to accept the out-patient for medical treatment and amount to 3862 examples, complete data person 1546 examples wherein are summarized as follows:
1, physical data
Diagnostic criteria meets " huang jiasi surgery " (the 7th edition) rated condition: the patient has or no conscious sympton, with B ultrasonic, X line or/CT finds calculus shape, companion or do not accompany in the urine that to discharge the sandstone granule be confirmed cases, wherein go up lithangiuria 1478 examples, calculus of lower urinary tract 68 examples, male 1269 examples, woman's 277 examples, the oldest 76 years old, minimum 2 years old 4 months, 34 years old mean age; One-sided calculus 1341 examples, bilateral calculus 205 examples; The minimum 5mm of calculus diameter, maximum 26 * 18mm is full of renal pelvis and is Cornu Cervi shape person 47 examples; The patient merges heavier stomach patient 74 examples simultaneously, coronary heart disease 29 examples, calculus of bile duct patient 157 examples, hypertension 18 examples, diabetes 17 examples, cyst of kidney 7 examples, other disease 56 examples; Be recurrent cases person's 1006 examples, lithotripsy in treatment person 727 examples once.Find when nearly 1/3rd cases are community's physical examination in addition.Press tcm syndrome differentiation and typing: Qi-stagnation type 326 examples, blood stasis type 433 examples, damp-heat type 302 examples, renal deficiency type 34 examples, nearly 1/5th cases do not have disease and can debate.
2, materials and methods
Select high-quality genuine traditional Chinese medicine material for use: Sal Nitri, Endothelium Corneum Gigeriae Galli, Alumen, Fructus Gardeniae, Spora Lygodii, Herba Lysimachiae, Semen Abutili, Folium Pyrrosiae, Herba Artemisiae Scopariae, succinum, Endoconcha Sepiae, Squama Manis, Semen Vaccariae, Herba Hedyotidis Diffusae, Olibanum, Myrrha, the Radix Paeoniae Alba, Rhizoma Imperatae, Radix Clematidis, Rhizoma Corydalis, Radix Curcumae, Talcum, Herba Dianthi, Radix Cyathulae, Rhizoma Polygoni Cuspidati, the Radix Astragali, Herba Taraxaci, Gryllotalpa, Semen Plantaginis, Herba Polygoni Avicularis, Asteriscus Pseudosciaenae, rhizoma sparganic, Rhizoma Curcumae, Spina Gleditsiae, Pericarpium Citri Reticulatae, Herba Ephedrae, Rhizoma Alismatis, Exocarpium Benincasae, Radix Notoginseng, Polyporus, Lignum Aquilariae Resinatum, Caulis Akebiae, 42 flavors such as Radix Et Rhizoma Rhei and Radix Rubiae, the clean after drying of handling, pulverized powder is crossed No. 5 80 mesh sieves, dress No. zero hard capsule, every heavy 0.5g of capsule, the width of cloth packages spare after penetrating sterilization.No matter what type differential diagnosis in tcm belongs to and which kind of composition calculus is doctor trained in Western medicine be judged as, the unified each 4-5 grain of adult that adopts, and every day 3 times, warm boiled water after the meal, child's consumption reduces by half, and 10 days was 1 course of treatment.Routine examination liver, renal function, myocardial enzymes, electrocardiogram and hematuria routine before and after taking medicine.Operated by rotary motion: one course of treatment of the above every 1mm of calculus diameter 3mm, the calculus diameter is long more the big more course of treatment, and period in a medicine is checked B ultrasonic 1 time per at least 3 courses of treatment, observes the litholysis degree.As occurring the calculus phenomenon in the drug administration process, the heavier person of pain continues intravenous drip can for 20mg intramuscular injection of Progesterone pin or mountain Liang rock alkali injection, till disappearing to pain.Later stage follows up a case by regular visits to same employing phone form and carries out.
3, result
Curative effect determinate standard: clinical cure: symptom, sign complete obiteration, imaging examination calculus shadow disappears; Produce effects: symptom and sign disappears substantially, and imaging examination calculus shadow dwindles or calculus quantity reduces more than 60%; Invalid: symptom and sign and image check do not have change or change not remarkable.Efficacy result sees Table:
1546 example treatment information slips
Attached: 1, less than 30 days is by 30 days, and less than 60 days is by 60 days, by that analogy more than 30 days.
2, preceding 60 days healing persons are the first example of curing the disease without rubble.
This is organized 2 examples and takes medicine that curative effect does not significantly change operation into more than 8 months, surplusly all obtains healing.Cure rate reaches 99.75%, and wherein healing person accounts for 91.6% in 5 months.Lithodialysis efficient average out to per course of treatment of 0.2～0.6mm, the calculus volume is big more, the time is of a specified duration more, many persons are long more the course of treatment more through the external stone crushing number of times, and are invalid to calculus in the cyst of kidney.Do not observe the heart, liver, kidney and the performance of blood aspect toxic reaction in the drug administration process.Do not find skin allergy and obvious side effect of digestive tract case, do not have more than 95% " calculus phenomenon " that calculus disappears in " unconsciously ".The person that has been combined the cholelithiasis receives the effect of killing two birds with one stone, effective percentage nearly 98%.The present invention is particularly useful for the invalid and all kinds recurrent case of rubble, and 80% above patient does not have the calculus reaction takes place, no intestinal, blood, skin and the heart, liver, kidney poison precursor reactant.Clinical safe in utilization, be convenient to promote.
Claims (3)
1. a Chinese medicine preparation for the treatment of urinary calculus is characterized in that it is to be made by following raw medicaments in portion by weight: 5～7 parts on Sal Nitri, 2～4 parts of Endothelium Corneum Gigeriae Galli, 5～7 parts of Alumens, 1～3 part of Fructus Gardeniae, 2～4 parts of Spora Lygodii, 5～7 parts of Herba Lysimachiaes, 3～5 parts of Semen Abutilis, 4～6 parts of Folium Pyrrosiae, 4～6 parts of Herba Artemisiae Scopariaes, 1～2 part of succinum, 2～3 parts of Endoconcha Sepiaes, 0.5～1.5 part of Squama Manis, 3～5 parts of Semen Vaccariae, 4～5 parts of Herba Hedyotidis Diffusaes, 0.5～1.5 part of Olibanum, 0.5～1.5 part of Myrrha, 3～5 parts of the Radix Paeoniae Albas, 5～7 parts of Rhizoma Imperataes, 5～7 parts of Radix Clematidis, 1～3 part of Rhizoma Corydalis, 3～5 parts of Radix Curcumaes, 3～5 parts in Talcum, 4～6 parts of Herba Dianthis, 3～5 parts of Radix Cyathulaes, 3～5 parts of Rhizoma Polygoni Cuspidati, 4～6 parts of the Radixs Astragali, 3～5 parts of Herba Taraxacis, 3～5 parts of Gryllotalpas, 4～6 parts of Semen Plantaginiss, 3～5 parts of Herba Polygoni Avicularis, 1～3 part of Asteriscus Pseudosciaenae, 0.5～1.5 part of rhizoma sparganic, 0.5～1.5 part of Rhizoma Curcumae, 2～3 parts of Spina Gleditsiae, 3～5 parts of Pericarpium Citri Reticulataes, 1～2 part in Herba Ephedrae, 3～4 parts of Rhizoma Alismatis, 3～4 parts of Exocarpium Benincasaes, 0.5～1.5 part of Radix Notoginseng, 3～5 parts of Polyporus, 0.2～0.8 part of Lignum Aquilariae Resinatum, 0.5～1.5 part of Caulis Akebiae, 0.5～1.5 part of Radix Et Rhizoma Rhei, 2～3 parts in Radix Rubiae.
2. according to the described a kind of Chinese medicine preparation for the treatment of urinary calculus of claim 1, it is characterized in that it is to be made by following raw medicaments in portion by weight: 5 parts on Sal Nitri, 4 parts of Endothelium Corneum Gigeriae Galli, 5 parts of Alumens, 2 parts of Fructus Gardeniaes, 4 parts of Spora Lygodii, 5 parts of Herba Lysimachiaes, 3 parts of Semen Abutilis, 4 parts of Folium Pyrrosiae, 4 parts of Herba Artemisiae Scopariaes, 1.5 parts of succinums, 2 parts of Endoconcha Sepiaes, 1 part of Squama Manis, 3 parts of Semen Vaccariae, 4 parts of Herba Hedyotidis Diffusaes, 1 part of Olibanum, 1 part of Myrrha, 3 parts of the Radix Paeoniae Albas, 5 parts of Rhizoma Imperataes, 5 parts of Radix Clematidis, 2 parts of Rhizoma Corydalis, 3 parts of Radix Curcumaes, 3 parts in Talcum, 4 parts of Herba Dianthis, 3 parts of Radix Cyathulaes, 3 parts of Rhizoma Polygoni Cuspidati, 4 parts of the Radixs Astragali, 5 parts of Herba Taraxacis, 3 parts of Gryllotalpas, 5 parts of Semen Plantaginiss, 5 parts of Herba Polygoni Avicularis, 3 parts of Asteriscus Pseudosciaenaes, 1 part of rhizoma sparganic, 1 part of Rhizoma Curcumae, 2 parts of Spina Gleditsiae, 3 parts of Pericarpium Citri Reticulataes, 1 part in Herba Ephedrae, 4 parts of Rhizoma Alismatis, 3 parts of Exocarpium Benincasaes, 1 part of Radix Notoginseng, 3 parts of Polyporus, 0.5 part of Lignum Aquilariae Resinatum, 1 part of Caulis Akebiae, 1 part of Radix Et Rhizoma Rhei, 2 parts in Radix Rubiae.
3. preparation method for the treatment of the urinary calculus Chinese medicine preparation as claimed in claim 1 or 2, this preparation method is as follows:
After described materials of weight proportions medicine Squama Manis, Olibanum, Myrrha, Rhizoma Corydalis concocted with conventional method, standby; With described materials of weight proportions medicine Sal Nitri, Endothelium Corneum Gigeriae Galli, Alumen, Fructus Gardeniae, Spora Lygodii, Herba Lysimachiae, Semen Abutili, Folium Pyrrosiae, Herba Artemisiae Scopariae, succinum, Endoconcha Sepiae, Semen Vaccariae, Herba Hedyotidis Diffusae, the Radix Paeoniae Alba, Rhizoma Imperatae, Radix Clematidis, Radix Curcumae, Talcum, Herba Dianthi, Radix Cyathulae, Rhizoma Polygoni Cuspidati, the Radix Astragali, Herba Taraxaci, Gryllotalpa, Semen Plantaginis, Herba Polygoni Avicularis, Asteriscus Pseudosciaenae, rhizoma sparganic, Rhizoma Curcumae, Spina Gleditsiae, Pericarpium Citri Reticulatae, Herba Ephedrae, Rhizoma Alismatis, Exocarpium Benincasae, Radix Notoginseng, Polyporus, Lignum Aquilariae Resinatum, Caulis Akebiae, Radix Et Rhizoma Rhei, the Squama Manis of Radix Rubiae after the back and the process of preparing Chinese medicine are handled in cleaning, Olibanum, Myrrha, Rhizoma Corydalis mixes, grind, cross 80 mesh sieves, get fine powder, sterilization incapsulates and gets final product.
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