CN102671169B - Traditional Chinese medicine for treating acute pelvic inflammatory disease and preparation method - Google Patents
Traditional Chinese medicine for treating acute pelvic inflammatory disease and preparation method Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for treating acute pelvic inflammatory disease. The traditional Chinese medicine comprises drugs for oral administration and drugs for external use, wherein the drugs for oral administration comprise rhizoma anemarrhenae, leaf of purpleflower holly, red ginseng, baked ginger, cogongrass rhizome, Oldenlandia diffusa, bighead atractylodes rhizome, Angelica sinensis, arillus longan, eclipta and Radix Ophiopogonis; and the drugs for external use comprise Rhodiola rosea, Carthamus tinctorious, Selaginella tamariscina, radix tinosporae, swertia mileensis, Rhizoma dioscoreae hypoglaucae, Erigeron breviscapus, cortex acanthopanacis, oriental wormwood, scutellaria baicalensis and borneol. By treating the acute pelvic inflammatory disease with the novel traditional Chinese medicine provided by the invention, subsiding of inflammation can be accelerated, thus, the course of treatment is shortened, the recovery rate is improved, and the recrudescence of the disease is avoided. The traditional Chinese medicine provided by the invention has the advantages of no toxic or side effects, no tolerance, and low price.
Description
Technical field
The present invention relates to the technology of pharmaceutical engineering field, relate in particular to a kind of for oral administration and external application Chinese medicine that is used for the treatment of acute pelvic inflammatory disease.
Background technology
Pelvic inflammatory disease (pelvic inflammatory disease, PID) refers on the women reproductive tract and the inflammation of connective tissue on every side thereof, mainly contains endometritis, salpingitis, tubo-ovarian cyst, pelvioperitonitis.Pelvic inflammatory disease mostly occurring in property active phase, the women of menstruation is arranged.According to national hospital leave hospital the investigation result, 15～28 years old age bracket women PID annual admission rates 49.3/10000 (being respectively 31.4/10000 and 48.6/10000 at 15～19 and 25～29 age group), in the U.S., annual cost because of PID is estimated between 800,000,000 dollars to 3,000,000,000 dollars.
Pelvic inflammatory disease is divided into again acute pelvic inflammatory disease and chronic pelvic inflammatory disease.Acute pelvic inflammatory disease refers to female internal genital organs and the acute inflammation that occurs of connective tissue, pelvic peritoneum on every side thereof, can be confined to a position, also can fall ill simultaneously at several positions.The acute pelvic inflammatory disease development can cause diffuse peritonitis, septicemia, septic shock, but the severe patient threat to life.If acute pelvic inflammatory disease fails to obtain in time correct treatment, can develop into pelvic inflammatory disease sequela (sequelae of PID) due to disorganization, extensively adhesion, hypertrophy and cicatrization.The leaving over change and can cause of salpingitis and adnexitis: salpingemphraxis, fallopian tube increase slightly; Fallopian tube ovary Adhesion formation fallopian tube ovary lump; Fimbriated extremity of fallopian locking, serous effusion are built up and are formed hydrosalpinx; The pus of pyosalpinx or tubo-ovarian abscess absorbs, and is replaced forming hydrosalpinx or tubo-ovarian cyst by serous effusion.Hydrops fallopian tube smooth surface, tube wall is very thin, because mesosalpinx can not enlarge and corresponding prolongation with the growth of hydrops fallopian tube cyst wall, therefore the hydrops fallopian tube is to the mesentery lateral bend, likeness in form sausage or be the distillation ampuliform of bent neck, backward curling, can dissociate or with surrounding tissue, the adhesion of film sample be arranged.
Master, sacrum ligament hypertrophy, thickening are changed in leaving over of inflammation of pelvic connective tissue, if pathological changes is extensive, the uterus are fixed.The clinical manifestation of pelvic inflammatory disease sequela can be (1), infertile: fallopian tube adhesion is blocked and can be caused infertilely, and after acute pelvic inflammatory disease, infertile incidence rate is 20%～30%.(2), ectopic pregnancy: after pelvic inflammatory disease, the ectopic pregnancy incidence rate is 8～10 times of normal women.These symptoms and sign reach the burden that increases economically the patient in spirit, have a strong impact on patient's life and work.So how to amass point-device treatment acute pelvic inflammatory disease, the generation that reduces the pelvic inflammatory disease sequela is the key for the treatment of pelvic inflammatory disease, and the active treatment of this acute pelvic inflammatory disease causes increasing scholar's attention and research.
Take antibiotic therapy as main, in time correct antibiotic therapy can be removed pathogen to doctor trained in Western medicine, improves symptom and sign, reduces sequela aspect the treatment acute pelvic inflammatory disease.Need use in conjunction when selecting antibiotic, and use antibiotic comparatively reasonable according to patient's drug sensitive experiment, but the doctor needs namely to give antibiotic therapy usually before obtaining laboratory result, therefore, initial therapy is rule of thumb selected antibiotic often.Because doctor trained in Western medicine majority in treatment is empirical medication, and mostly being penicillins, metronidazole and two kinds of Antibiotic combinations of erythromycin series uses, when the use in conjunction poor effect, be difficult to treat disorganization, extensively adhesion, hypertrophy and cicatrix because inflammatory infiltration causes, and finally develop into the pelvic inflammatory disease sequela.
Summary of the invention
Technical problem to be solved by this invention is, overcome the deficiency of existing western medical treatment acute pelvic inflammatory disease, adopt Novel Chinese medicine medicine treatment acute pelvic inflammatory disease, it can accelerate inflammation and disappear, thereby Shorten the Treatment Process, improve cure rate, and the state of an illness is not repeatedly, Chinese medicine of the present invention has no side effect, has no drug resistance, low price.
Ask in order to solve above-mentioned technology, the invention provides a kind of Chinese medicine for the treatment of acute pelvic inflammatory disease, it comprises: endo-medicine is, the Rhizoma Anemarrhenae, Ilex purpurea Hassk.[I.chinensis Sims, Radix Ginseng Rubra, Rhizoma Zingiberis Preparatum, Rhizoma Imperatae, Herba Hedyotidis Diffusae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Arillus Longan, Herba Ecliptae, Radix Ophiopogonis;
External used medicine is, Radix Rhodiolae, Flos Carthami, Herba Selaginellae, Radix Tinosporae, Herba Swertiae Mileensis, Rhizoma Dioscoreae Hypoglaucae, Herba Erigerontis, Cortex Acanthopancis, Herba Artemisiae Scopariae, Radix Scutellariae, Borneolum Syntheticum.
Wherein, the ratio of weight and number of each component in described Chinese medicine is:
Endo-medicine is, the Rhizoma Anemarrhenae 60～70 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 35～45 weight portions, Radix Ginseng Rubra 10～20 weight portions, Rhizoma Zingiberis Preparatum 25～35 weight portions, Rhizoma Imperatae 22～32 weight portions, Herba Hedyotidis Diffusae 6～12 weight portions, the Rhizoma Atractylodis Macrocephalae 13～21 weight portions, Radix Angelicae Sinensis 14～20 weight portions, Arillus Longan 8～16 weight portions, Herba Ecliptae 12～18 weight portions, Radix Ophiopogonis 9～15 weight portion.
Wherein, the ratio of weight and number of each component in described Chinese medicine is:
External used medicine is, Radix Rhodiolae 25～35 weight portions, Flos Carthami 50～60 weight portions, Herba Selaginellae 20～30 weight portions, Radix Tinosporae 16～22 weight portions, Herba Swertiae Mileensis 12～18 weight portions, Rhizoma Dioscoreae Hypoglaucae 10～16 weight portions, Herba Erigerontis 24～30 weight portions, Cortex Acanthopancis 8～15 weight portions, Herba Artemisiae Scopariae 12～18 weight portions, Radix Scutellariae 10～16 weight portions, Borneolum Syntheticum 6～10 weight portions.
Wherein, the ratio of weight and number of each component in described Chinese medicine is more preferably:
Endo-medicine is, the Rhizoma Anemarrhenae 65～70 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 40～45 weight portions, Radix Ginseng Rubra 15～20 weight portions, Rhizoma Zingiberis Preparatum 30～35 weight portions, Rhizoma Imperatae 28～32 weight portions, Herba Hedyotidis Diffusae 8～12 weight portions, the Rhizoma Atractylodis Macrocephalae 17～21 weight portions, Radix Angelicae Sinensis 16～20 weight portions, Arillus Longan 12～16 weight portions, Herba Ecliptae 15～18 weight portions, Radix Ophiopogonis 12～15 weight portion.
Wherein, the ratio of weight and number of each component in described Chinese medicine is more preferably:
External used medicine is, Radix Rhodiolae 30～35 weight portions, Flos Carthami 55～60 weight portions, Herba Selaginellae 25～30 weight portions, Radix Tinosporae 20～22 weight portions, Herba Swertiae Mileensis 16～18 weight portions, Rhizoma Dioscoreae Hypoglaucae 13～16 weight portions, Herba Erigerontis 27～30 weight portions, Cortex Acanthopancis 12～15 weight portions, Herba Artemisiae Scopariae 15～18 weight portions, Radix Scutellariae 12～16 weight portions, Borneolum Syntheticum 8～10 weight portions.
Wherein, the ratio of weight and number of each component in described Chinese medicine further is preferably:
Endo-medicine is, the Rhizoma Anemarrhenae 68 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 42 weight portions, Radix Ginseng Rubra 18 weight portions, Rhizoma Zingiberis Preparatum 33 weight portions, Rhizoma Imperatae 30 weight portions, Herba Hedyotidis Diffusae 10 weight portions, the Rhizoma Atractylodis Macrocephalae 19 weight portions, Radix Angelicae Sinensis 18 weight portions, Arillus Longan 14 weight portions, Herba Ecliptae 16 weight portions, Radix Ophiopogonis 14 weight portion.
Wherein, the ratio of weight and number of each component in described Chinese medicine further is preferably:
External used medicine is, Radix Rhodiolae 32 weight portions, Flos Carthami 58 weight portions, Herba Selaginellae 27 weight portions, Radix Tinosporae 21 weight portions, Herba Swertiae Mileensis 17 weight portions, Rhizoma Dioscoreae Hypoglaucae 14 weight portions, Herba Erigerontis 29 weight portions, Cortex Acanthopancis 14 weight portions, Herba Artemisiae Scopariae 16 weight portions, Radix Scutellariae 14 weight portions, Borneolum Syntheticum 9 weight portions.
The present invention also provides the preparation method of above-mentioned Chinese medicine, and the dosage form of the external used medicine of described Chinese medicine is cleanout fluid, and its preparation method comprises the following steps,
the first step, each component of described external used medicine is mixed in proportion, adding determining alcohol with respect to 2～4 times of mixture qualities is 70～80% ethanol, reflux 1～3 hour, extract 2～3 times, merge extractive liquid, filter and obtain alcohol extract, the alcohol extract concentrating under reduced pressure, be recycled to without the alcohol flavor, the medicinal residues that filter to obtain add the distilled water of 4～8 times of the mixture qualities that form with respect to each component of external used medicine again, decocted 1～3 hour, decoct 2～3 times, filter respectively, merging filtrate gets water extraction liquid, water extraction liquid concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract that obtains previously, further concentrating under reduced pressure, desolventizing, dry, obtain and get dry extract,
Second step, the dried cream that the first step is obtained is placed on pulverizes 1～2 hour in super micron mill, pulverize, and sieves, and obtains 600 orders～800 purpose micropowders;
The 3rd step was dissolved in the micropowders that obtains in distilled water with respect to 3～5 times of its quality, and slow fire boiling 2～4 hours is filtered, and filtrate is cleanout fluid.
The present invention also provides the preparation method of above-mentioned Chinese medicine, and the preparation method of the endo-medicine of described Chinese medicine comprises the following steps,
the first step, each component of described endo-medicine is mixed in proportion, adding determining alcohol with respect to 2～4 times of mixture qualities is 70～80% ethanol, reflux 1～3 hour, extract 2～3 times, merge extractive liquid, filter and obtain alcohol extract, the alcohol extract concentrating under reduced pressure, be recycled to without the alcohol flavor, the medicinal residues that filter to obtain add the distilled water of 4～8 times of the mixture qualities that form with respect to each component of external used medicine again, decocted 1～3 hour, decoct 2～3 times, filter respectively, merging filtrate gets water extraction liquid, water extraction liquid concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract that obtains previously, further concentrating under reduced pressure, desolventizing, dry, obtain and get dry extract,
Second step, the dried cream that the first step is obtained is placed on pulverizes 1～2 hour in super micron mill, pulverize, and sieves, and obtains 600 orders～800 purpose micropowders;
In the 3rd step, the micropowders that second step is obtained is the preparation method of dosage form routinely, is prepared into various dosage forms.
Wherein, when the dosage form of described endo-medicine was tablet, described the 3rd step was specially the micropowders that second step is obtained, and added microcrystalline Cellulose with respect to 0.1～0.3 times of its quality, 0.05～0.15 times of lactose, the starch 60g of 0.1～0.3 times, sieve, mix homogeneously is granulated, drying, add with respect to 0.005～0.05 times of magnesium stearate of micropowders quality, granulate, tabletting is made 1000.
Wherein, when the dosage form of described endo-medicine is oral liquid, described the 3rd step is specially the sucrose that adds with respect to 0.05～0.1 times of its quality in the micropowders that second step obtains, 0.005～0.01 times of sodium benzoate, mix homogeneously, add again with respect to the water of 3～5 times of micropowders quality and make, sterilization, packing gets final product.
Wherein, when the dosage form of described endo-medicine was capsule, described the 3rd step was specially in the micropowders that second step obtains and adds successively Pulvis Talci, magnesium stearate, carries out mixing and processes, and namely gets capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15～0.5: 0.15～0.5, and described capsule 's content is incapsulated in housing, namely get the capsule finished product.
Beneficial effect of the present invention:
Adopts new medicine of the present invention treatment acute pelvic inflammatory disease, can accelerate inflammation and disappear, thereby Shorten the Treatment Process improve cure rate, and the state of an illness is not repeatedly, Chinese medicine of the present invention have have no side effect, have no drug resistance, low-cost advantage.
The specific embodiment
The traditional Chinese medical science is thought after the many disposal of performing the operation in puerperal, post-abortion, uterine cavity of acute pelvic inflammatory disease, or menstrual hygiene health care improper when, evil poison is taken advantage of a weak point in opponent's defence and is attacked, delay Yu Chongren and uterus venation, with the QI and blood knot of fighting mutually, evil quadrature is striven, and heating stomachache, the flourishing slough pyogenesis of evil poison, even general is acute peritonitis, septic shock.The etiology and pathogenesis of acute pelvic inflammatory disease can be divided into: 1, excessive noxious heat: menstrual period, puerperal, post-abortion, and surgical injury, weak born of the same parents are empty, insufficiency of vital energy and blood, chamber does not save, and invades in evil poison, and the visitor is in uterus, stagnantly appoints in punching, and poison is made in heat-transformation, causes high heat stomachache not peaceful; 2, Accumulation of Dampness Heat and Blood Stasis: through row puerperal, remaining blood is unclean, invades in damp and hot, fights mutually with remaining blood, rushes the retardance of conception vessel network, and stasis is not smooth, and blood stasis and damp and hot interior knot, stagnant in few abdomen, suffers from abdominal pain leukorrhagia with the passing of time, and touching difficulty heals.
therefore, the present invention treats acute pelvic inflammatory disease take heat-clearing and toxic substances removing as main, the damp eliminating blood stasis dispelling is auxiliary, by the heat-clearing and detoxifying herb composition to various bacteria, virus has inhibition, the effect of killing, the energy anti-inflammation, antiviral, increase phagocytic function, the immunocompetence of enhancing body to infecting, the blood-activating and stasis-removing composition has obvious reduction hair cell vascular permeability to reduce inflammatory exudation, suppress the connective tissue proliferation effect, can improve blood circulation and tissue metabolism, nutrition, fortifying fibre protein dissolution enzymatic activity, promote inflammation to absorb, tissue repair and regeneration, and coordinate heat-clearing and toxic substances removing medicine performance antiinflammatory by immune system, detumescence, the effects such as analgesia, two class components are share, make the anti-inflammation increased functionality, adhesion organization is softening, be beneficial to absorption and do not stay future trouble, avoid simultaneously causing the human body dysbacteriosis to cause that he is sick because of long-term a large amount of antibiotic that use.
Chinese medicine of the present invention has improved patient's immunity greatly, and its whole symptom and sign is improved, can Shorten the Treatment Process, improve curative effect, from alleviating economically and mentally patient's burden, reduce the trend that transfers chronic pelvic inflammatory disease to, more be conducive to treatment and the prognosis of acute pelvic inflammatory disease.
Based on above-mentioned theory, the invention provides a kind of Chinese medicine for the treatment of acute pelvic inflammatory disease, it comprises: endo-medicine is, the Rhizoma Anemarrhenae, Ilex purpurea Hassk.[I.chinensis Sims, Radix Ginseng Rubra, Rhizoma Zingiberis Preparatum, Rhizoma Imperatae, Herba Hedyotidis Diffusae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Arillus Longan, Herba Ecliptae, Radix Ophiopogonis;
External used medicine is, Radix Rhodiolae, Flos Carthami, Herba Selaginellae, Radix Tinosporae, Herba Swertiae Mileensis, Rhizoma Dioscoreae Hypoglaucae, Herba Erigerontis, Cortex Acanthopancis, Herba Artemisiae Scopariae, Radix Scutellariae, Borneolum Syntheticum.
Wherein, the ratio of weight and number of each component in described Chinese medicine is:
Endo-medicine is, the Rhizoma Anemarrhenae 60～70 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 35～45 weight portions, Radix Ginseng Rubra 10～20 weight portions, Rhizoma Zingiberis Preparatum 25～35 weight portions, Rhizoma Imperatae 22～32 weight portions, Herba Hedyotidis Diffusae 6～12 weight portions, the Rhizoma Atractylodis Macrocephalae 13～21 weight portions, Radix Angelicae Sinensis 14～20 weight portions, Arillus Longan 8～16 weight portions, Herba Ecliptae 12～18 weight portions, Radix Ophiopogonis 9～15 weight portion;
External used medicine is, Radix Rhodiolae 25～35 weight portions, Flos Carthami 50～60 weight portions, Herba Selaginellae 20～30 weight portions, Radix Tinosporae 16～22 weight portions, Herba Swertiae Mileensis 12～18 weight portions, Rhizoma Dioscoreae Hypoglaucae 10～16 weight portions, Herba Erigerontis 24～30 weight portions, Cortex Acanthopancis 8～15 weight portions, Herba Artemisiae Scopariae 12～18 weight portions, Radix Scutellariae 10～16 weight portions, Borneolum Syntheticum 6～10 weight portions.
Wherein, the ratio of weight and number of each component in described Chinese medicine is more preferably:
Endo-medicine is, the Rhizoma Anemarrhenae 65～70 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 40～45 weight portions, Radix Ginseng Rubra 15～20 weight portions, Rhizoma Zingiberis Preparatum 30～35 weight portions, Rhizoma Imperatae 28～32 weight portions, Herba Hedyotidis Diffusae 8～12 weight portions, the Rhizoma Atractylodis Macrocephalae 17～21 weight portions, Radix Angelicae Sinensis 16～20 weight portions, Arillus Longan 12～16 weight portions, Herba Ecliptae 15～18 weight portions, Radix Ophiopogonis 12～15 weight portion;
External used medicine is, Radix Rhodiolae 30～35 weight portions, Flos Carthami 55～60 weight portions, Herba Selaginellae 25～30 weight portions, Radix Tinosporae 20～22 weight portions, Herba Swertiae Mileensis 16～18 weight portions, Rhizoma Dioscoreae Hypoglaucae 13～16 weight portions, Herba Erigerontis 27～30 weight portions, Cortex Acanthopancis 12～15 weight portions, Herba Artemisiae Scopariae 15～18 weight portions, Radix Scutellariae 12～16 weight portions, Borneolum Syntheticum 8～10 weight portions.
Wherein, the ratio of weight and number of each component in described Chinese medicine is more preferably:
Endo-medicine is, the Rhizoma Anemarrhenae 68 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 42 weight portions, Radix Ginseng Rubra 18 weight portions, Rhizoma Zingiberis Preparatum 33 weight portions, Rhizoma Imperatae 30 weight portions, Herba Hedyotidis Diffusae 10 weight portions, the Rhizoma Atractylodis Macrocephalae 19 weight portions, Radix Angelicae Sinensis 18 weight portions, Arillus Longan 14 weight portions, Herba Ecliptae 16 weight portions, Radix Ophiopogonis 14 weight portion;
External used medicine is, Radix Rhodiolae 32 weight portions, Flos Carthami 58 weight portions, Herba Selaginellae 27 weight portions, Radix Tinosporae 21 weight portions, Herba Swertiae Mileensis 17 weight portions, Rhizoma Dioscoreae Hypoglaucae 14 weight portions, Herba Erigerontis 29 weight portions, Cortex Acanthopancis 14 weight portions, Herba Artemisiae Scopariae 16 weight portions, Radix Scutellariae 14 weight portions, Borneolum Syntheticum 9 weight portions.
The present invention also provides the preparation method of above-mentioned Chinese medicine, and wherein, the dosage form of described external used medicine is cleanout fluid, and its preparation method comprises the following steps,
the first step, each component of described external used medicine is mixed in proportion, adding determining alcohol with respect to 2～4 times of mixture qualities is 70～80% ethanol, reflux 1～3 hour, extract 2～3 times, merge extractive liquid, filter and obtain alcohol extract, the alcohol extract concentrating under reduced pressure, be recycled to without the alcohol flavor, the medicinal residues that filter to obtain add the distilled water of 4～8 times of the mixture qualities that form with respect to each component of external used medicine again, decocted 1～3 hour, decoct 2～3 times, filter respectively, merging filtrate gets water extraction liquid, water extraction liquid concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract that obtains previously, further concentrating under reduced pressure, desolventizing, dry, obtain and get dry extract,
Second step, the dried cream that the first step is obtained is placed on pulverizes 1～2 hour in super micron mill, pulverize, and sieves, and obtains 600 orders～800 purpose micropowders;
The 3rd step was dissolved in the micropowders that obtains in distilled water with respect to 3～5 times of its quality, and slow fire boiling 2～4 hours is filtered, and filtrate is cleanout fluid.
The present invention also provides the preparation method of above-mentioned Chinese medicine, and wherein, the dosage form of described endo-medicine is tablet, and its preparation method comprises the following steps,
the first step, each component of described endo-medicine is mixed in proportion, adding determining alcohol with respect to 2～4 times of mixture qualities is 70～80% ethanol, reflux 1～3 hour, extract 2～3 times, merge extractive liquid, filter and obtain alcohol extract, the alcohol extract concentrating under reduced pressure, be recycled to without the alcohol flavor, the medicinal residues that filter to obtain add the distilled water of 4～8 times of the mixture qualities that form with respect to each component of external used medicine again, decocted 1～3 hour, decoct 2～3 times, filter respectively, merging filtrate gets water extraction liquid, water extraction liquid concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract that obtains previously, further concentrating under reduced pressure, desolventizing, dry, obtain and get dry extract,
Second step, the dried cream that the first step is obtained is placed on pulverizes 1～2 hour in super micron mill, pulverize, and sieves, and obtains 600 orders～800 purpose micropowders;
The 3rd step, micropowders with the second step acquisition, add microcrystalline Cellulose with respect to 0.1～0.3 times of its quality, 0.05～0.15 times of lactose, the starch of 0.1～0.3 times, sieve, mix homogeneously, granulate, drying adds with respect to 0.005～0.05 times of magnesium stearate of micropowders quality, granulate, tabletting is made 1000.
The present invention also provides the preparation method of above-mentioned Chinese medicine, and wherein, the dosage form of described endo-medicine is oral liquid, and its preparation method comprises the following steps,
the first step, each component of described endo-medicine is mixed in proportion, adding determining alcohol with respect to 2～4 times of mixture qualities is 70～80% ethanol, reflux 1～3 hour, extract 2～3 times, merge extractive liquid, filter and obtain alcohol extract, the alcohol extract concentrating under reduced pressure, be recycled to without the alcohol flavor, the medicinal residues that filter to obtain add the distilled water of 4～8 times of the mixture qualities that form with respect to each component of external used medicine again, decocted 1～3 hour, decoct 2～3 times, filter respectively, merging filtrate gets water extraction liquid, water extraction liquid concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract that obtains previously, further concentrating under reduced pressure, desolventizing, dry, obtain and get dry extract,
Second step, the dried cream that the first step is obtained is placed on pulverizes 1～2 hour in super micron mill, pulverize, and sieves, and obtains 600 orders～800 purpose micropowders;
The 3rd step added the sucrose with respect to 0.05～0.1 times of its quality in the micropowders that second step obtains, 0.005～0.01 times of sodium benzoate, and mix homogeneously, then add with respect to the water of 3～5 times of micropowders quality and make, sterilization, packing gets final product.
The present invention also provides the preparation method of above-mentioned Chinese medicine, and wherein, the dosage form of described endo-medicine is capsule, and its preparation method comprises the following steps,
the first step, each component of described endo-medicine is mixed in proportion, adding determining alcohol with respect to 2～4 times of mixture qualities is 70～80% ethanol, reflux 1～3 hour, extract 2～3 times, merge extractive liquid, filter and obtain alcohol extract, the alcohol extract concentrating under reduced pressure, be recycled to without the alcohol flavor, the medicinal residues that filter to obtain add the distilled water of 4～8 times of the mixture qualities that form with respect to each component of external used medicine again, decocted 1～3 hour, decoct 2～3 times, filter respectively, merging filtrate gets water extraction liquid, water extraction liquid concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract that obtains previously, further concentrating under reduced pressure, desolventizing, dry, obtain and get dry extract,
Second step, the dried cream that the first step is obtained is placed on pulverizes 1～2 hour in super micron mill, pulverize, and sieves, and obtains 600 orders～800 purpose micropowders;
The 3rd step added Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, carry out mixing and process, and namely got capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15～0.5: 0.15～0.5, and described capsule 's content is incapsulated in housing, namely get the capsule finished product.
In endo-medicine, each component pharmacology is as follows:
The Rhizoma Anemarrhenae: bitter in the mouth, sweet, cold in nature, enter lung, stomach, kidney channel, the relieving restlessness of purging heat is arranged, the effect of nourshing Yin and drynsessmoistening prescription, clearing away lung-heat to relieve cough cures mainly fever caused by exogenous pathogenic factors, and high heat is irritated, lung-heat type cough, the interior-heat symptom such as quench one's thirst; Its bitter cold matter profit, the property sedimentation can heat clearing away, can promote the production of body fluid again, kindly controls warm pathogenic factor and enters edema caused by disorder of QI, the intenseness of heat impairment of body fluid; Also be used for the treatment of diabetes; Phlegm-heat obstructing in the lung and breathing heavily, the xeropulmonary cough, expectorant is few unfavorable; Hyperactivity of fire caused by deficiency of YIN, the symptoms such as hyperactivity of deficient fire.
Ilex purpurea Hassk.[I.chinensis Sims: bitter in the mouth, cold in nature, return lung, large intestine, urinary bladder channel, have heat-clearing and toxic substances removing, the effect of promoting blood circulation and hemostasis is used for chronic tracheitis, pyelonephritis, bacillary dysentery; Burn and scald is controlled in external, ulcer of the lower limb, and leprelcosis, extra earning is hemorrhage, cold injury, mastitis, the cards such as chapped skin.
Radix Ginseng Rubra: sweet in the mouth, little hardship, warm in nature, return spleen, lung, heart channel, have strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and the effect of nourishing qi to stop is used for weak body and prostration, cold extremities faint pulse, QI failing to control blood, metrostaxis; Heart failure, the cards such as cardiogenic shock.
Rhizoma Zingiberis Preparatum: acrid in the mouth, hot in nature, return spleen, stomach, kidney, the heart, lung meridian, have warming spleen and stomach for dispelling cold, the effect of warming the meridian for stopping bleeding is used for Deficiency and coldness of spleen and stomach, and stomachache is vomited and diarrhoea, and tells the nosebleed metrorrhagia, the yang deficiency card such as lose blood.
Rhizoma Imperatae: sweet in the mouth, cold in nature, enter lung, stomach, small intestine meridian, have cooling blood for hemostasis, the clearing away heat and promoting diuresis effect cures mainly heat in blood and spits blood, epistaxis spitting of blood, hematuria, metrorrhagia, purpura, calentura excessive thirst, gastric heat vomiting, dyspnea and cough due to lung-heat, the puckery pain of dribbling urination, edema, the cards such as jaundice.
Herba Hedyotidis Diffusae: bitter in the mouth, sweet, cold in nature, enter the heart, liver, spleen, large intestine channel has heat-clearing and toxic substances removing, the effect of promoting diuresis to eliminate damp pathogen is used for dyspnea and cough due to lung-heat, laryngopharynx swelling and pain, acute appendicitis, furuncle and phyma skin infection, venom, the puckery pain of pyretic stranguria, edema, dysentery, enteritis, jaundice due to damp-heat, the cards such as cancerous protuberance.
The Rhizoma Atractylodis Macrocephalae: sweet in the mouth, hardship, warm in nature, enter spleen, stomach warp, the spleen reinforcing promoting the circulation of QI is arranged, the dampness diuretic, strengthening superficial resistance to stop perspiration, the effect that activating the spleen is moisturized is mainly used in the feeling of fullness diarrhoea due to dysfunction of the spleen in transportation, QI failing to transform into body fluid, the phlegm retention edema; The vexed lazy speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; The cards such as solid in the playing of deficiency of the spleen causing weakness of QI, sweating due to debility spontaneous perspiration.
Radix Angelicae Sinensis: sweet in the mouth, suffering, warm in nature, enter liver, the heart, spleen channel, enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, the effect of loosening bowel to relieve constipation is mainly used in blood and invigorates blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for the cards such as blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
Arillus Longan: warm in nature, distinguish the flavor of sweet, have invigorating the heart and spleen, the effect of nourishing blood to tranquillize the mind is used for the cards such as insufficiency of vital energy and blood, severe palpitation, forgetful insomnia, blood deficiency and yellow complexion.
Herba Ecliptae: sweet in the mouth, acid, cold in nature, return liver, kidney channel, play not liver and kidney tonifying, the effect of cooling blood for hemostasis is used for having a dizzy spell due to the hepatic and renal YIN deficiency, blurring of vision, soreness of the waist and knees; Being suitable for the deficiency of YIN has hot person, is used for the treatment of the haematemesis of accumulated heat in stomach, the symptoms such as the hemoptysis of injury of blood vessel of the lung by heat.
Radix Ophiopogonis: sweet in the mouth, little hardship, cold nature, GUIXIN, lung, stomach warp have YIN nourishing and the production of body fluid promoting, and the effect that lung moistening clears away heart-fire is used for dryness of the lung dry cough, and deficiency of YIN consumptive disease is coughed, the sore throat pharyngalgia, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, the cards such as dryness of the intestine constipation.
In external used medicine, each component pharmacology is as follows:
Radix Rhodiolae: sweet in the mouth, hardship, property is flat, returns lung, heart channel, has benefiting QI for activating blood circulation, and the effect of promoting blood circulation and relievining asthma is used for blood stasis due to qi deficiency, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, the cards such as asthenia asthma.
Flos Carthami: warm in nature, acrid in the mouth enters, the heart, Liver Channel, has promoting blood circulation to restore menstrual flow, and the effect of stasis-dispelling and pain-killing is used for amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, injury from falling down, the skin infection disease such as swell and ache.
Herba Selaginellae: acrid in the mouth, property is flat, returns liver, heart channel, has the effect of promoting blood circulation to restore menstrual flow, is used for amenorrhea dysmenorrhea ， WEIJIA mass in the abdomen, and injury from falling down is spitted blood, and metrorrhagia is had blood in stool, the cards such as proctoptosis.
Radix Tinosporae: bitter in the mouth, cold in nature, return lung, large intestine channel, have heat-clearing and toxic substances removing, the effect of relieving sore throat and pain is used for laryngopharynx swelling and pain, and the carbuncle furunculosis is had loose bowels, dysentery, the cards such as gastral cavity abdomen burning pain.
Herba Swertiae Mileensis: bitter in the mouth, cold in nature, return liver, gallbladder, urinary bladder channel, have heat-clearing and toxic substances removing, the effect of dampness removing jaundice eliminating cures mainly jaundice due to damp-heat; The puckery pain of pyretic stranguria; Damp-heat dysentery; Leucorrhea with red and white discharge; Influenza; The malaria heating; Acute gastritis; Acute pharyngolaryngitis; The cards such as acute tonsillitis.
Rhizoma Dioscoreae Hypoglaucae: bitter in the mouth, property is flat, enters liver, stomach, urinary bladder channel, has a dampness removing turbid, wind-damp dispelling, the effect of heat-clearing and toxic substances removing is used for stranguria marked by chyluria, nebulousurine, leukorrhagia, rheumatic arthralgia, soreness of waist and knee joint, bottom sore swollen toxin, the cards such as eczema.
Herba Erigerontis: acrid in the mouth, little hardship, warm in nature, have expelling cold and relieving exterior syndrome, expelling wind and removing dampness, the effect of activating collaterals to relieve pain is used for headache due to common cold, toothache, stomachache, rheumatalgia, the paralysis that cerebrovascular accident causes, the cards such as osteomyelitis.
Cortex Acanthopancis: acrid in the mouth, hardship, warm in nature, return liver, kidney channel, have wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening, the effect of the arteries and veins of invigorating blood circulation is used for anemofrigid-damp arthralgia; Lumbocrural pain; The muscles and bones flaccidity is soft; Children's's walking retardation in children; Body void is frail; Traumatic injury; Fracture; Edema; Foot gas; The uncontrolled urination card such as itch.
Herba Artemisiae Scopariae: bitter in the mouth, suffering, cold nature enters spleen, stomach, liver, gallbladder meridian, has clearing away damp-heat, and the effect of jaundice eliminating subcutaneous ulcer is used for jaundice, and no matter damp and hot YANG jaundice or cold-damp YIN jaundice all can be used, and also can be applicable to due to fever disease in summer or hygropyrexia the cards such as oliguria with reddish urine.
Radix Scutellariae: bitter in the mouth, cold in nature, enter the heart, lung, stomach, gallbladder, large intestine channel, heat clearing and damp drying is arranged, eliminating fire and detoxication, antiabortive, the effect of hemostasis is mainly used in diarrhoea, dysentery, jaundice, pyretic stranguria due to damp and hot; The cough due to lung-heat, thirsty pharyngalgia also can be used for excessive fetal movement due to heat in pregnancy, and the pyretic toxicity pathogenic fire is invaded the swollen card of carbuncle sore poison of excessive skin.
Borneolum Syntheticum: acrid in the mouth, hardship, cool in nature, enter the heart, lung meridian, have logical all keys, loose stagnated fire, removing nebula makes eye bright, the effect of reducing swelling and alleviating pain cures mainly the apoplexy locked mouth, calentura coma, infantile convulsion expectorant fan, deafness with qi stagnation, sore throat, aphtha, otitis media, carbuncle, hemorrhoid, order is the nebula film also, the cards such as enterobiasis.
Below adopt embodiment to describe embodiments of the present invention in detail, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
External used medicine cleanout fluid in the Chinese medicine of embodiment 1 the present invention's preparation
with Radix Rhodiolae 32g, Flos Carthami 58g, Herba Selaginellae 27g, Radix Tinosporae 21g, Herba Swertiae Mileensis 17g, Rhizoma Dioscoreae Hypoglaucae 14g, Herba Erigerontis 29g, Cortex Acanthopancis 14g, Herba Artemisiae Scopariae 16g, Radix Scutellariae 14g, Borneolum Syntheticum 9g mixes, the determining alcohol that adds 750g is 80% ethanol, reflux 2 hours, extract 3 times, merge extractive liquid, filter and obtain alcohol extract, the alcohol extract concentrating under reduced pressure, be recycled to without the alcohol flavor, filter the distilled water that the medicinal residues that obtain add 1300g again, the each decoction 2 hours, decoct altogether 3 times, filter respectively, merging filtrate gets water extraction liquid, water extraction liquid concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract that obtains previously, further concentrating under reduced pressure, desolventizing, dry, obtain and get dry extract, the dried cream that obtains is placed in super micron mill pulverized 2 hours, pulverize, sieve, obtain 800 purpose micropowders, the micropowders that obtains is dissolved in the distilled water of 1000g, slow fire boiling 3 hours, filter, filtrate is cleanout fluid.
Endo-medicine tablet in the Chinese medicine of embodiment 2 the present invention's preparations
with Rhizoma Anemarrhenae 68g, Ilex purpurea Hassk.[I.chinensis Sims 42g, Radix Ginseng Rubra 18g, Rhizoma Zingiberis Preparatum 33g, Rhizoma Imperatae 30g, Herba Hedyotidis Diffusae 10g, Rhizoma Atractylodis Macrocephalae 19g, Radix Angelicae Sinensis 18g, Arillus Longan 14g, Herba Ecliptae 16g, Radix Ophiopogonis, 14g mixed, the determining alcohol that adds 850g is 80% ethanol, reflux 2 hours, extract 3 times, merge extractive liquid,, filter and obtain alcohol extract, the alcohol extract concentrating under reduced pressure, be recycled to without the alcohol flavor, filter the distilled water that the medicinal residues that obtain add 1500g again, the each decoction 2 hours, decoct 3 times, filter respectively, merging filtrate gets water extraction liquid, water extraction liquid concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract that obtains previously, further concentrating under reduced pressure, desolventizing, dry, obtain and get dry extract, the dried cream that obtains is placed in super micron mill pulverized 2 hours, pulverize, sieve, obtain 800 purpose micropowders, with the micropowders that obtains, the microcrystalline Cellulose that adds 30g, the 20g lactose, the starch of 30g sieves, and mix homogeneously is granulated, and drying adds the 3g magnesium stearate, granulate, and tabletting is made 1000.
Endo-medicine oral liquid in the Chinese medicine of embodiment 3 the present invention's preparations
with Rhizoma Anemarrhenae 68g, Ilex purpurea Hassk.[I.chinensis Sims 42g, Radix Ginseng Rubra 18g, Rhizoma Zingiberis Preparatum 33g, Rhizoma Imperatae 30g, Herba Hedyotidis Diffusae 10g, Rhizoma Atractylodis Macrocephalae 19g, Radix Angelicae Sinensis 18g, Arillus Longan 14g, Herba Ecliptae 16g, Radix Ophiopogonis, 14g mixed, the determining alcohol that adds 850g is 80% ethanol, reflux 2 hours, extract 3 times, merge extractive liquid, filter and obtain alcohol extract, the alcohol extract concentrating under reduced pressure, be recycled to without the alcohol flavor, filter the distilled water that the medicinal residues that obtain add 1500g again, the each decoction 2 hours, decoct 3 times, filter respectively, merging filtrate gets water extraction liquid, water extraction liquid concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract that obtains previously, further concentrating under reduced pressure, desolventizing, dry, obtain and get dry extract, the dried cream that obtains is placed in super micron mill pulverized 2 hours, pulverize, sieve, obtain 800 purpose micropowders, the sucrose of 25g will be added in the micropowders that obtain, the 2g sodium benzoate, mix homogeneously, the water that adds again 1100g is made, sterilization, packing gets final product.
Endo-medicine capsule in the Chinese medicine of embodiment 4 the present invention's preparations
with Rhizoma Anemarrhenae 68g, Ilex purpurea Hassk.[I.chinensis Sims 42g, Radix Ginseng Rubra 18g, Rhizoma Zingiberis Preparatum 33g, Rhizoma Imperatae 30g, Herba Hedyotidis Diffusae 10g, Rhizoma Atractylodis Macrocephalae 19g, Radix Angelicae Sinensis 18g, Arillus Longan 14g, Herba Ecliptae 16g, Radix Ophiopogonis, 14g mixed, the determining alcohol that adds 850g is 80% ethanol, reflux 2 hours, extract 3 times, merge extractive liquid,, filter and obtain alcohol extract, the alcohol extract concentrating under reduced pressure, be recycled to without the alcohol flavor, filter the distilled water that the medicinal residues that obtain add 1500g again, the each decoction 2 hours, decoct 3 times, filter respectively, merging filtrate gets water extraction liquid, water extraction liquid concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract that obtains previously, further concentrating under reduced pressure, desolventizing, dry, obtain and get dry extract, the dried cream that obtains is placed in super micron mill pulverized 2 hours, pulverize, sieve, obtain 800 purpose micropowders, add successively the 0.8g Pulvis Talci in the micropowders that obtains, 0.8g magnesium stearate is carried out mixing and is processed, and namely gets capsule 's content, and described capsule 's content is incapsulated in housing, namely gets the capsule finished product.
Clinical experiment
1.1 basic clinical data
The acute pelvic inflammatory disease patient that accept for medical treatment this clinical experiment employing the court is totally 276 examples, is divided at random 2 groups, treatment group 200 examples, 22～49 years old age, average 35.5 years old.5～16d, on average 10.5d are in hospital; Western medicine group 76 examples, 20～42 years old age, average 31 years old.Length of stay 7～22d, the diagnostic criteria of average 14.5d acute pelvic inflammatory disease is with reference to U.S. CDC (CDC) in 2002 diagnostic criteria.Syndrome Differentiation of Traditional Chinese Medicine is divided into noxious dampness and stops up Sheng type, warm stasis type with reference to the Standards of Chinese Medical Syndrome Differentiation of pelvic inflammatory disease in " new Chinese medicine guideline of clinical investigations ".
Two groups of patients of clinical symptoms and sign all show obvious lower abdominal pain, aggravate the shiver with cold that occurs together simultaneously, heating when fatigue and sexual intercourse.Most of patient is with leucorrhoea grow in quantity and abnormal flavour.Inducement mostly is suffers from cold menstrual period, unclean sexual intercourse or miscarriage etc.The obvious tenderness of the lower abdomen of having a medical check-up, peritoneal irritation sign is positive.The obvious tenderness of gynecologial examination palace body or adnexa, list or bilateral attachment area all thicken, tenderness or lay one's hand on and tenderness property enclosed mass.The auxiliary examination all cases all points out list or bilateral attachment area to thicken in various degree through ultrasound diagnosis, and broadening or inflammatory mass even have hydrosalpinx (empyema), the performance that pelvic hydrops exists.The laboratory checks leucocytosis.
1.2 Therapeutic Method
Matched group adopts intravenous drip ampicillin sulbactam+amikacin+metronidazole, and 1 time/d, 7～10d is 1 course for the treatment of, after withdraw the previous remark and take antibiotic 7d after treatment.
Treatment group adopts the endo-medicine oral liquid of the embodiment of the present invention 3 preparations, each 100ml, every day 3 times, adopt simultaneously the external used medicine cleanout fluid of the mode external embodiment of the present invention 1 preparation of coloclysis, namely choose cleanout fluid 100ml, retention enema, temperature (40 ± 1) ℃, 1 time/d, 7～10d is 1 course for the treatment of.Patient's empty bladder is got lateral position, with enemator, warm medicinal liquid 100ml is slowly poured in intestinal retention enema.
1.3 statistical method
Adopt SPSS 16.0 softwares to carry out statistical analysis.
1.4 evaluation criterion
Cure: the clinical symptoms sign all disappears, and B ultrasonic shows that list or bilateral adnexa recover normal, and inflammatory masses of pelvic cavity and inflammatory exudate all disappear.Take a turn for the better: the clinical symptoms sign is clearly better, and B ultrasonic shows that list or bilateral adnexa increase slightly and take a favorable turn, and inflammatory masses of pelvic cavity and inflammatory exudate dwindle or reduce 〉=and 1/3.Invalid: the clinical symptoms sign is without improvement, and B ultrasonic shows that list or bilateral inflammatory masses of ovarian appendages inflammatory exudate are without improvement.
1.5 result sees Table 1
Table 1 liang group patient clinical curative effect is (%) relatively
| Group | Number of cases | Cure | Take a turn for the better | Invalid | Total effective rate |
| Treatment group | 200 | 153 | 43 | 4 | 98％ |
| Matched group | 76 | 20 | 38 | 18 | 76.3％ |
Table 1 can find out, the curative effect for the treatment of group of the present invention will be significantly better than matched group.
This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, is not to be the present invention to be done the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away to any simple modification, equivalent variations and remodeling that above embodiment does, still belongs to the protection domain of technical solution of the present invention according to technical spirit of the present invention.
Claims (7)
1. a Chinese medicine for the treatment of acute pelvic inflammatory disease, is characterized in that, comprising: endo-medicine is, the Rhizoma Anemarrhenae, Ilex purpurea Hassk.[I.chinensis Sims, Radix Ginseng Rubra, Rhizoma Zingiberis Preparatum, Rhizoma Imperatae, Herba Hedyotidis Diffusae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Arillus Longan, Herba Ecliptae, Radix Ophiopogonis;
External used medicine is, Radix Rhodiolae, Flos Carthami, Herba Selaginellae, Radix Tinosporae, Herba Swertiae Mileensis, Rhizoma Dioscoreae Hypoglaucae, Herba Erigerontis, Cortex Acanthopancis, Herba Artemisiae Scopariae, Radix Scutellariae, Borneolum Syntheticum;
The ratio of weight and number of each component in described Chinese medicine is,
Endo-medicine is, the Rhizoma Anemarrhenae 60～70 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 35～45 weight portions, Radix Ginseng Rubra 10～20 weight portions, Rhizoma Zingiberis Preparatum 25～35 weight portions, Rhizoma Imperatae 22～32 weight portions, Herba Hedyotidis Diffusae 6～12 weight portions, the Rhizoma Atractylodis Macrocephalae 13～21 weight portions, Radix Angelicae Sinensis 14～20 weight portions, Arillus Longan 8～16 weight portions, Herba Ecliptae 12～18 weight portions, Radix Ophiopogonis 9～15 weight portion;
External used medicine is, Radix Rhodiolae 25～35 weight portions, Flos Carthami 50～60 weight portions, Herba Selaginellae 20～30 weight portions, Radix Tinosporae 16～22 weight portions, Herba Swertiae Mileensis 12～18 weight portions, Rhizoma Dioscoreae Hypoglaucae 10～16 weight portions, Herba Erigerontis 24～30 weight portions, Cortex Acanthopancis 8～15 weight portions, Herba Artemisiae Scopariae 12～18 weight portions, Radix Scutellariae 10～16 weight portions, Borneolum Syntheticum 6～10 weight portions.
2. Chinese medicine as claimed in claim 1 is characterized in that: the ratio of weight and number of each component in described Chinese medicine is,
Endo-medicine is, the Rhizoma Anemarrhenae 65～70 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 40～45 weight portions, Radix Ginseng Rubra 15～20 weight portions, Rhizoma Zingiberis Preparatum 30～35 weight portions, Rhizoma Imperatae 28～32 weight portions, Herba Hedyotidis Diffusae 8～12 weight portions, the Rhizoma Atractylodis Macrocephalae 17～21 weight portions, Radix Angelicae Sinensis 16～20 weight portions, Arillus Longan 12～16 weight portions, Herba Ecliptae 15～18 weight portions, Radix Ophiopogonis 12～15 weight portion.
3. Chinese medicine as claimed in claim 1 or 2 is characterized in that: the ratio of weight and number of each component in described Chinese medicine is,
External used medicine is, Radix Rhodiolae 30～35 weight portions, Flos Carthami 55～60 weight portions, Herba Selaginellae 25～30 weight portions, Radix Tinosporae 20～22 weight portions, Herba Swertiae Mileensis 16～18 weight portions, Rhizoma Dioscoreae Hypoglaucae 13～16 weight portions, Herba Erigerontis 27～30 weight portions, Cortex Acanthopancis 12～15 weight portions, Herba Artemisiae Scopariae 15～18 weight portions, Radix Scutellariae 12～16 weight portions, Borneolum Syntheticum 8～10 weight portions.
4. the preparation method of Chinese medicine as claimed in claim 1 or 2 is characterized in that:
The dosage form of the external used medicine of described Chinese medicine is cleanout fluid, and its preparation method comprises the following steps,
the first step, each component of described external used medicine is mixed in proportion, adding determining alcohol with respect to 2～4 times of mixture qualities is 70～80% ethanol, reflux 1～3 hour, extract 2～3 times, merge extractive liquid, filter and obtain alcohol extract, the alcohol extract concentrating under reduced pressure, be recycled to without the alcohol flavor, the medicinal residues that filter to obtain add the distilled water of 4～8 times of the mixture qualities that form with respect to each component of external used medicine again, decocted 1～3 hour, decoct 2～3 times, filter respectively, merging filtrate gets water extraction liquid, water extraction liquid concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract that obtains previously, further concentrating under reduced pressure, desolventizing, dry, obtain and get dry extract,
Second step, the dried cream that the first step is obtained is placed on pulverizes 1～2 hour in super micron mill, pulverize, and sieves, and obtains 600 orders～800 purpose micropowders;
The 3rd step was dissolved in the micropowders that obtains in distilled water with respect to 3～5 times of its quality, and slow fire boiling 2～4 hours is filtered, and filtrate is cleanout fluid.
5. the preparation method of Chinese medicine as claimed in claim 1 or 2 is characterized in that:
The preparation method of the endo-medicine of described Chinese medicine comprises the following steps,
the first step, each component of described endo-medicine is mixed in proportion, adding determining alcohol with respect to 2～4 times of mixture qualities is 70～80% ethanol, reflux 1～3 hour, extract 2～3 times, merge extractive liquid, filter and obtain alcohol extract, the alcohol extract concentrating under reduced pressure, be recycled to without the alcohol flavor, the medicinal residues that filter to obtain add the distilled water of 4～8 times of the mixture qualities that form with respect to each component of external used medicine again, decocted 1～3 hour, decoct 2～3 times, filter respectively, merging filtrate gets water extraction liquid, water extraction liquid concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract that obtains previously, further concentrating under reduced pressure, desolventizing, dry, obtain and get dry extract,
Second step, the dried cream that the first step is obtained is placed on pulverizes 1～2 hour in super micron mill, pulverize, and sieves, and obtains 600 orders～800 purpose micropowders;
In the 3rd step, the micropowders that second step is obtained is the preparation method of dosage form routinely, is prepared into various dosage forms.
6. the preparation method of Chinese medicine as claimed in claim 5 is characterized in that:
When the dosage form of described endo-medicine is oral liquid, described the 3rd step is specially the sucrose that adds with respect to 0.05～0.1 times of its quality in the micropowders that second step obtains, 0.005～0.01 times of sodium benzoate, mix homogeneously, add again with respect to the water of 3～5 times of micropowders quality and make, sterilization, packing gets final product.
7. the preparation method of Chinese medicine as claimed in claim 5 is characterized in that:
When the dosage form of described endo-medicine was capsule, described the 3rd step was specially in the micropowders that second step obtains and adds successively Pulvis Talci, magnesium stearate, carries out mixing and processes, and namely gets capsule 's content;
Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15～0.5: 0.15～0.5, and described capsule 's content is incapsulated in housing, namely get the capsule finished product.
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