CN102671169A - Traditional Chinese medicine for treating acute pelvic inflammatory disease and preparation method - Google Patents
Traditional Chinese medicine for treating acute pelvic inflammatory disease and preparation method Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for treating acute pelvic inflammatory disease. The traditional Chinese medicine comprises drugs for oral administration and drugs for external use, wherein the drugs for oral administration comprise rhizoma anemarrhenae, leaf of purpleflower holly, red ginseng, baked ginger, cogongrass rhizome, Oldenlandia diffusa, bighead atractylodes rhizome, Angelica sinensis, arillus longan, eclipta and Radix Ophiopogonis; and the drugs for external use comprise Rhodiola rosea, Carthamus tinctorious, Selaginella tamariscina, radix tinosporae, swertia mileensis, Rhizoma dioscoreae hypoglaucae, Erigeron breviscapus, cortex acanthopanacis, oriental wormwood, scutellaria baicalensis and borneol. By treating the acute pelvic inflammatory disease with the novel traditional Chinese medicine provided by the invention, subsiding of inflammation can be accelerated, thus, the course of treatment is shortened, the recovery rate is improved, and the recrudescence of the disease is avoided. The traditional Chinese medicine provided by the invention has the advantages of no toxic or side effects, no tolerance, and low price.
Description
Technical field
The present invention relates to the pharmaceutical engineering technical field, relate in particular to a kind of for oral administration and external Chinese medicine that is used to treat acute pelvic inflammatory disease.
Background technology
(pelvic inflammatory disease PID) refers on the women reproductive tract and the inflammation of connective tissue on every side thereof to pelvic inflammatory disease, mainly contains endometritis, salpingitis, tubo-ovarian cyst, pelvioperitonitis.Pelvic inflammatory disease mostly occurring in property active phase, the women of menstruation is arranged.According to national hospital leave hospital the investigation the result; 15～28 years old age bracket women PID annual admission rates 49.3/10000 (being respectively 31.4/10000 and 48.6/10000) at 15～19 and 25～29 age group; In the U.S., annual cost because of PID is estimated between 800,000,000 dollars to 3,000,000,000 dollars.
Pelvic inflammatory disease is divided into acute pelvic inflammatory disease and chronic pelvic inflammatory disease again.Acute pelvic inflammatory disease is meant female internal genital organs and the acute inflammation that takes place of connective tissue, pelvic peritoneum on every side thereof, can be confined to a position, also can fall ill simultaneously at several positions.The acute pelvic inflammatory disease development can cause diffuse peritonitis, septicemia, septic shock, but the severe patient threat to life.If acute pelvic inflammatory disease fails to obtain correct treatment in time, can develop into pelvic inflammatory disease sequela (sequelae of PID) owing to disorganization, extensively adhesion, hypertrophy and cicatrization.The leaving over change and can cause of salpingitis and adnexitis: salpingemphraxis, fallopian tube increase slightly; The adhesion of fallopian tube ovary forms the fallopian tube Ovarian Tumor; Fimbriated extremity of fallopian locking, serous effusion are built up and are formed hydrosalpinx; The pus of pyosalpinx or tubo-ovarian abscess absorbs, and is replaced forming hydrosalpinx or tubo-ovarian cyst by serous effusion.Hydrops fallopian tube smooth surface, tube wall is very thin, because mesosalpinx can not enlarge and corresponding prolongation with the growth of hydrops fallopian tube cyst wall; So the hydrops fallopian tube is bent to the mesentery lateral bending; Likeness in form sausage or be the distillation ampuliform of bent neck curls backward, can dissociate or with surrounding tissue the adhesion of film appearance is arranged.
Master, sacrum ligament hypertrophy, thickening are changed in leaving over of inflammation of pelvic connective tissue, if pathological changes is extensive, can make fixed uterus.The clinical manifestation of pelvic inflammatory disease sequela can be (1), infertile: fallopian tube adhesion is blocked and can be caused infertilely, and infertile incidence rate is 20%～30% after the acute pelvic inflammatory disease.(2), ectopic pregnancy: the ectopic pregnancy incidence rate is 8～10 times of normal women after the pelvic inflammatory disease.These symptoms and sign reach the burden that increases the patient economically in spirit, have a strong impact on patient's life and work.So correct treatment acute pelvic inflammatory disease how actively, the generation that reduces the pelvic inflammatory disease sequela is the key of treatment pelvic inflammatory disease, and the active treatment of this acute pelvic inflammatory disease causes the attention and the research of more and more scholars.
Doctor trained in Western medicine is being main with antibiotic therapy aspect the treatment acute pelvic inflammatory disease, and in time correct antibiotic therapy can be removed pathogen, improves symptom and sign, reduces sequela.Need Combined application when selecting antibiotic, and use antibiotic comparatively reasonable according to patient's drug sensitive experiment, but the doctor needs before obtaining laboratory result, promptly to give antibiotic therapy usually, therefore, initial therapy is rule of thumb selected antibiotic often.Because doctor trained in Western medicine majority in treatment is empirical medication; And be mostly PCs, metronidazole and two kinds of antibiotic Combined application of erythromycin series; When the Combined application poor effect; Be difficult to treat disorganization, extensively adhesion, hypertrophy and cicatrix, and finally develop into the pelvic inflammatory disease sequela because of inflammatory infiltration causes.
Summary of the invention
Technical problem to be solved by this invention is; Overcome the deficiency of existing western medical treatment acute pelvic inflammatory disease, adopt novel Chinese medicine acute pelvic inflammatory disease, it can quicken inflammation and disappear; Thereby shorten the course of treatment; Improve cure rate, and the state of an illness is not repeatedly, Chinese medicine of the present invention has no side effect, has no drug resistance, low price.
Ask that in order to solve above-mentioned technology the invention provides a kind of Chinese medicine of treating acute pelvic inflammatory disease, it comprises: endo-medicine is the Rhizoma Anemarrhenae, Ilex purpurea Hassk.[I.chinensis Sims, Radix Ginseng Rubra, Rhizoma Zingiberis Preparatum, Rhizoma Imperatae, Herba Hedyotidis Diffusae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Arillus Longan, Herba Ecliptae, Radix Ophiopogonis;
External used medicine is Radix Rhodiolae, Flos Carthami, Herba Selaginellae, Radix Tinosporae, Herba Swertiae Mileensis, Rhizoma Dioscoreae Hypoglaucae, Herba Erigerontis, Cortex Acanthopancis, Herba Artemisiae Scopariae, Radix Scutellariae, Borneolum Syntheticum.
Wherein, the ratio of weight and number of each component in the said Chinese medicine is:
Endo-medicine does, the Rhizoma Anemarrhenae 60～70 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 35～45 weight portions, Radix Ginseng Rubra 10～20 weight portions, Rhizoma Zingiberis Preparatum 25～35 weight portions, Rhizoma Imperatae 22～32 weight portions, Herba Hedyotidis Diffusae 6～12 weight portions, the Rhizoma Atractylodis Macrocephalae 13～21 weight portions, Radix Angelicae Sinensis 14～20 weight portions, Arillus Longan 8～16 weight portions, Herba Ecliptae 12～18 weight portions, Radix Ophiopogonis 9～15 weight portion.
Wherein, the ratio of weight and number of each component in the said Chinese medicine is:
External used medicine is Radix Rhodiolae 25～35 weight portions, Flos Carthami 50～60 weight portions, Herba Selaginellae 20～30 weight portions, Radix Tinosporae 16～22 weight portions, Herba Swertiae Mileensis 12～18 weight portions, Rhizoma Dioscoreae Hypoglaucae 10～16 weight portions, Herba Erigerontis 24～30 weight portions, Cortex Acanthopancis 8～15 weight portions, Herba Artemisiae Scopariae 12～18 weight portions, Radix Scutellariae 10～16 weight portions, Borneolum Syntheticum 6～10 weight portions.
Wherein, the ratio of weight and number of each component in the said Chinese medicine further is preferably:
Endo-medicine does, the Rhizoma Anemarrhenae 65～70 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 40～45 weight portions, Radix Ginseng Rubra 15～20 weight portions, Rhizoma Zingiberis Preparatum 30～35 weight portions, Rhizoma Imperatae 28～32 weight portions, Herba Hedyotidis Diffusae 8～12 weight portions, the Rhizoma Atractylodis Macrocephalae 17～21 weight portions, Radix Angelicae Sinensis 16～20 weight portions, Arillus Longan 12～16 weight portions, Herba Ecliptae 15～18 weight portions, Radix Ophiopogonis 12～15 weight portion.
Wherein, the ratio of weight and number of each component in the said Chinese medicine further is preferably:
External used medicine is Radix Rhodiolae 30～35 weight portions, Flos Carthami 55～60 weight portions, Herba Selaginellae 25～30 weight portions, Radix Tinosporae 20～22 weight portions, Herba Swertiae Mileensis 16～18 weight portions, Rhizoma Dioscoreae Hypoglaucae 13～16 weight portions, Herba Erigerontis 27～30 weight portions, Cortex Acanthopancis 12～15 weight portions, Herba Artemisiae Scopariae 15～18 weight portions, Radix Scutellariae 12～16 weight portions, Borneolum Syntheticum 8～10 weight portions.
Wherein, the ratio of weight and number of each component in the said Chinese medicine further is preferably:
Endo-medicine does, the Rhizoma Anemarrhenae 68 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 42 weight portions, Radix Ginseng Rubra 18 weight portions, Rhizoma Zingiberis Preparatum 33 weight portions, Rhizoma Imperatae 30 weight portions, Herba Hedyotidis Diffusae 10 weight portions, the Rhizoma Atractylodis Macrocephalae 19 weight portions, Radix Angelicae Sinensis 18 weight portions, Arillus Longan 14 weight portions, Herba Ecliptae 16 weight portions, Radix Ophiopogonis 14 weight portion.
Wherein, the ratio of weight and number of each component in the said Chinese medicine further is preferably:
External used medicine is Radix Rhodiolae 32 weight portions, Flos Carthami 58 weight portions, Herba Selaginellae 27 weight portions, Radix Tinosporae 21 weight portions, Herba Swertiae Mileensis 17 weight portions, Rhizoma Dioscoreae Hypoglaucae 14 weight portions, Herba Erigerontis 29 weight portions, Cortex Acanthopancis 14 weight portions, Herba Artemisiae Scopariae 16 weight portions, Radix Scutellariae 14 weight portions, Borneolum Syntheticum 9 weight portions.
The present invention also provides above-mentioned preparation method of Chinese medicine, and the dosage form of the external used medicine of said Chinese medicine is a cleanout fluid, and its preparation method may further comprise the steps,
The first step with each component proportional mixing of said external used medicine, adds determining alcohol with respect to 2～4 times of mixture qualities and is 70～80% ethanol, reflux 1～3 hour; Extract 2～3 times, merge extractive liquid, filters and obtains alcohol extract, alcohol extract concentrating under reduced pressure; Being recycled to does not have the alcohol flavor, filters the distilled water that the medicinal residues that obtain add 4～8 times of the mixture qualities formed with respect to each component of external used medicine again, decocts 1～3 hour, decocts 2～3 times; Filter respectively, merging filtrate gets the water extract, water extract concentrating under reduced pressure, and the concentrated solution of the alcohol extract that obtains with the front mixes; Further concentrating under reduced pressure removes and desolvates, and drying obtains and gets dry extract;
In second step, the dried cream that the first step is obtained is placed on pulverizes 1～2 hour in the super micron mill, pulverize, and sieves, and obtains 600 orders～800 purpose micropowders;
The 3rd step was dissolved in the micropowders that obtains in the distilled water with respect to 3～5 times of its quality, and slow fire boiling 2～4 hours is filtered, and filtrating is cleanout fluid.
The present invention also provides above-mentioned preparation method of Chinese medicine, and the method for preparing of the endo-medicine of said Chinese medicine may further comprise the steps,
The first step with each component proportional mixing of said endo-medicine, adds determining alcohol with respect to 2～4 times of mixture qualities and is 70～80% ethanol, reflux 1～3 hour; Extract 2～3 times, merge extractive liquid, filters and obtains alcohol extract, alcohol extract concentrating under reduced pressure; Being recycled to does not have the alcohol flavor, filters the distilled water that the medicinal residues that obtain add 4～8 times of the mixture qualities formed with respect to each component of external used medicine again, decocts 1～3 hour, decocts 2～3 times; Filter respectively, merging filtrate gets the water extract, water extract concentrating under reduced pressure, and the concentrated solution of the alcohol extract that obtains with the front mixes; Further concentrating under reduced pressure removes and desolvates, and drying obtains and gets dry extract;
In second step, the dried cream that the first step is obtained is placed on pulverizes 1～2 hour in the super micron mill, pulverize, and sieves, and obtains 600 orders～800 purpose micropowders;
In the 3rd step, the method for preparing with the micropowders of second step acquisition is pressed regular dosage form is prepared into various dosage forms.
Wherein, when the dosage form of said endo-medicine was tablet, said the 3rd step was specially the micropowders that second step was obtained; Adding is sieved mix homogeneously with respect to the microcrystalline Cellulose of 0.1～0.3 times of its quality, 0.05～0.15 times of lactose, 0.1～0.3 times starch 60g; Granulate, drying adds with respect to 0.005～0.05 times of magnesium stearate of micropowders quality; Granulate, tabletting is processed 1000.
Wherein, When the dosage form of said endo-medicine was oral liquid, said the 3rd step was specially in the micropowders that obtains in second step and adds the sucrose with respect to 0.05～0.1 times of its quality, 0.005～0.01 times of sodium benzoate; Mix homogeneously; Add again with respect to the water of 3～5 times of micropowders quality and process, sterilization, packing gets final product.
Wherein, when the dosage form of said endo-medicine was capsule, said the 3rd step was specially in the micropowders that obtains in second step and adds Pulvis Talci, magnesium stearate successively, carries out mixing and handles, and promptly gets capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15～0.5: 0.15～0.5, and described capsule 's content is incapsulated in the housing, promptly get the capsule finished product.
Beneficial effect of the present invention:
Adopt new medicine of the present invention treatment acute pelvic inflammatory disease, can quicken inflammation and disappear, thereby shorten the course of treatment, improve cure rate, and the state of an illness is not repeatedly, Chinese medicine of the present invention have have no side effect, have no drug resistance, low-cost advantage.
The specific embodiment
The traditional Chinese medical science is thought the many surgical site postpones in puerperal, post-abortion, uterine cavity of acute pelvic inflammatory disease, or the menstrual hygiene health care improper when, the invasion and attack of taking advantage of a weak point in opponent's defence of evil poison; Delay Yu Chongren and uterus venation; With the QI and blood knot of fighting mutually, evil quadrature is striven, and heating stomachache; The flourishing then slough pyogenesis of evil poison, even general be acute peritonitis, septic shock.The etiology and pathogenesis of acute pelvic inflammatory disease can be divided into: 1, excessive noxious heat: menstrual period, puerperal, post-abortion, and surgical injury, weak born of the same parents are empty, insufficiency of vital energy and blood, chamber does not save, and invades in the evil poison, and the visitor stagnates and appoints in dashing in uterus, and poison is made in heat-transformation, and it is not peaceful to cause hyperpyrexia stomachache; 2, damp and hot stasis of blood knot: through row puerperal, surplus blood is unclean, invades in damp and hot, fights mutually with surplus blood, and towards the retardance of conception vessel network, stasis of blood knot is not smooth, then blood stasis with damp and hot in knot, stagnate in few abdomen, then suffer from abdominal pain leukorrhagia with the passing of time, touching difficulty heals.
Therefore, it is main with heat-clearing and toxic substances removing that the present invention treats acute pelvic inflammatory disease, and the damp eliminating blood stasis dispelling is auxilliary; Through the effect that the heat-clearing and detoxifying herb composition has inhibition, kills various bacteria, virus, ability anti-inflammation, antiviral; Increase phagocytic function, the immunocompetence of enhancing body to infecting, the blood-activating and stasis-removing composition has obvious reduction hair cell vascular permeability to reduce inflammatory exudation; Suppress the connective tissue proliferation effect, can improve local blood circulation and tissue metabolism, nutrition, fortifying fibre protein dissolution enzymatic activity; Promote inflammation to absorb, tissue repair and regeneration, and coordinate the heat-clearing and toxic substances removing medicine through immune system and bring into play effects such as antiinflammatory, detumescence, analgesia; Two types of components are share, and make the anti-inflammation increased functionality, and adhesion organization is softening; Be beneficial to absorption and do not stay future trouble, avoid simultaneously causing the human body dysbacteriosis to cause that his is sick because of long-term a large amount of antibiotic that use.
Chinese medicine of the present invention has improved patient's immunity greatly, and its whole symptom and sign is improved, and can shorten the course of treatment; Improve curative effect; From alleviating patient's burden economically and mentally, reduce the trend that transfers chronic pelvic inflammatory disease to, more help the treatment and the prognosis of acute pelvic inflammatory disease.
Based on above-mentioned theory, the invention provides a kind of Chinese medicine of treating acute pelvic inflammatory disease, it comprises: endo-medicine is the Rhizoma Anemarrhenae, Ilex purpurea Hassk.[I.chinensis Sims, Radix Ginseng Rubra, Rhizoma Zingiberis Preparatum, Rhizoma Imperatae, Herba Hedyotidis Diffusae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Arillus Longan, Herba Ecliptae, Radix Ophiopogonis;
External used medicine is Radix Rhodiolae, Flos Carthami, Herba Selaginellae, Radix Tinosporae, Herba Swertiae Mileensis, Rhizoma Dioscoreae Hypoglaucae, Herba Erigerontis, Cortex Acanthopancis, Herba Artemisiae Scopariae, Radix Scutellariae, Borneolum Syntheticum.
Wherein, the ratio of weight and number of each component in the said Chinese medicine is:
Endo-medicine does, the Rhizoma Anemarrhenae 60～70 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 35～45 weight portions, Radix Ginseng Rubra 10～20 weight portions, Rhizoma Zingiberis Preparatum 25～35 weight portions, Rhizoma Imperatae 22～32 weight portions, Herba Hedyotidis Diffusae 6～12 weight portions, the Rhizoma Atractylodis Macrocephalae 13～21 weight portions, Radix Angelicae Sinensis 14～20 weight portions, Arillus Longan 8～16 weight portions, Herba Ecliptae 12～18 weight portions, Radix Ophiopogonis 9～15 weight portion;
External used medicine is Radix Rhodiolae 25～35 weight portions, Flos Carthami 50～60 weight portions, Herba Selaginellae 20～30 weight portions, Radix Tinosporae 16～22 weight portions, Herba Swertiae Mileensis 12～18 weight portions, Rhizoma Dioscoreae Hypoglaucae 10～16 weight portions, Herba Erigerontis 24～30 weight portions, Cortex Acanthopancis 8～15 weight portions, Herba Artemisiae Scopariae 12～18 weight portions, Radix Scutellariae 10～16 weight portions, Borneolum Syntheticum 6～10 weight portions.
Wherein, the ratio of weight and number of each component in the said Chinese medicine further is preferably:
Endo-medicine does, the Rhizoma Anemarrhenae 65～70 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 40～45 weight portions, Radix Ginseng Rubra 15～20 weight portions, Rhizoma Zingiberis Preparatum 30～35 weight portions, Rhizoma Imperatae 28～32 weight portions, Herba Hedyotidis Diffusae 8～12 weight portions, the Rhizoma Atractylodis Macrocephalae 17～21 weight portions, Radix Angelicae Sinensis 16～20 weight portions, Arillus Longan 12～16 weight portions, Herba Ecliptae 15～18 weight portions, Radix Ophiopogonis 12～15 weight portion;
External used medicine is Radix Rhodiolae 30～35 weight portions, Flos Carthami 55～60 weight portions, Herba Selaginellae 25～30 weight portions, Radix Tinosporae 20～22 weight portions, Herba Swertiae Mileensis 16～18 weight portions, Rhizoma Dioscoreae Hypoglaucae 13～16 weight portions, Herba Erigerontis 27～30 weight portions, Cortex Acanthopancis 12～15 weight portions, Herba Artemisiae Scopariae 15～18 weight portions, Radix Scutellariae 12～16 weight portions, Borneolum Syntheticum 8～10 weight portions.
Wherein, the ratio of weight and number of each component in the said Chinese medicine further is preferably:
Endo-medicine does, the Rhizoma Anemarrhenae 68 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 42 weight portions, Radix Ginseng Rubra 18 weight portions, Rhizoma Zingiberis Preparatum 33 weight portions, Rhizoma Imperatae 30 weight portions, Herba Hedyotidis Diffusae 10 weight portions, the Rhizoma Atractylodis Macrocephalae 19 weight portions, Radix Angelicae Sinensis 18 weight portions, Arillus Longan 14 weight portions, Herba Ecliptae 16 weight portions, Radix Ophiopogonis 14 weight portion;
External used medicine is Radix Rhodiolae 32 weight portions, Flos Carthami 58 weight portions, Herba Selaginellae 27 weight portions, Radix Tinosporae 21 weight portions, Herba Swertiae Mileensis 17 weight portions, Rhizoma Dioscoreae Hypoglaucae 14 weight portions, Herba Erigerontis 29 weight portions, Cortex Acanthopancis 14 weight portions, Herba Artemisiae Scopariae 16 weight portions, Radix Scutellariae 14 weight portions, Borneolum Syntheticum 9 weight portions.
The present invention also provides above-mentioned preparation method of Chinese medicine, and wherein, the dosage form of said external used medicine is a cleanout fluid, and its preparation method may further comprise the steps,
The first step with each component proportional mixing of said external used medicine, adds determining alcohol with respect to 2～4 times of mixture qualities and is 70～80% ethanol, reflux 1～3 hour; Extract 2～3 times, merge extractive liquid, filters and obtains alcohol extract, alcohol extract concentrating under reduced pressure; Being recycled to does not have the alcohol flavor, filters the distilled water that the medicinal residues that obtain add 4～8 times of the mixture qualities formed with respect to each component of external used medicine again, decocts 1～3 hour, decocts 2～3 times; Filter respectively, merging filtrate gets the water extract, water extract concentrating under reduced pressure, and the concentrated solution of the alcohol extract that obtains with the front mixes; Further concentrating under reduced pressure removes and desolvates, and drying obtains and gets dry extract;
In second step, the dried cream that the first step is obtained is placed on pulverizes 1～2 hour in the super micron mill, pulverize, and sieves, and obtains 600 orders～800 purpose micropowders;
The 3rd step was dissolved in the micropowders that obtains in the distilled water with respect to 3～5 times of its quality, and slow fire boiling 2～4 hours is filtered, and filtrating is cleanout fluid.
The present invention also provides above-mentioned preparation method of Chinese medicine, and wherein, the dosage form of said endo-medicine is a tablet, and its preparation method may further comprise the steps,
The first step with each component proportional mixing of said endo-medicine, adds determining alcohol with respect to 2～4 times of mixture qualities and is 70～80% ethanol, reflux 1～3 hour; Extract 2～3 times, merge extractive liquid, filters and obtains alcohol extract, alcohol extract concentrating under reduced pressure; Being recycled to does not have the alcohol flavor, filters the distilled water that the medicinal residues that obtain add 4～8 times of the mixture qualities formed with respect to each component of external used medicine again, decocts 1～3 hour, decocts 2～3 times; Filter respectively, merging filtrate gets the water extract, water extract concentrating under reduced pressure, and the concentrated solution of the alcohol extract that obtains with the front mixes; Further concentrating under reduced pressure removes and desolvates, and drying obtains and gets dry extract;
In second step, the dried cream that the first step is obtained is placed on pulverizes 1～2 hour in the super micron mill, pulverize, and sieves, and obtains 600 orders～800 purpose micropowders;
In the 3rd step,, add microcrystalline Cellulose with respect to 0.1～0.3 times of its quality, 0.05～0.15 times of lactose, 0.1～0.3 times starch with the micropowders that second step obtained; Sieve, mix homogeneously is granulated; Drying adds with respect to 0.005～0.05 times of magnesium stearate of micropowders quality, granulate; Tabletting is processed 1000.
The present invention also provides above-mentioned preparation method of Chinese medicine, and wherein, the dosage form of said endo-medicine is an oral liquid, and its preparation method may further comprise the steps,
The first step with each component proportional mixing of said endo-medicine, adds determining alcohol with respect to 2～4 times of mixture qualities and is 70～80% ethanol, reflux 1～3 hour; Extract 2～3 times, merge extractive liquid, filters and obtains alcohol extract, alcohol extract concentrating under reduced pressure; Being recycled to does not have the alcohol flavor, filters the distilled water that the medicinal residues that obtain add 4～8 times of the mixture qualities formed with respect to each component of external used medicine again, decocts 1～3 hour, decocts 2～3 times; Filter respectively, merging filtrate gets the water extract, water extract concentrating under reduced pressure, and the concentrated solution of the alcohol extract that obtains with the front mixes; Further concentrating under reduced pressure removes and desolvates, and drying obtains and gets dry extract;
In second step, the dried cream that the first step is obtained is placed on pulverizes 1～2 hour in the super micron mill, pulverize, and sieves, and obtains 600 orders～800 purpose micropowders;
The 3rd step added the sucrose with respect to 0.05～0.1 times of its quality in the micropowders of second step acquisition, 0.005～0.01 times of sodium benzoate, and mix homogeneously adds with respect to the water of 3～5 times of micropowders quality again and processes, sterilization, packing gets final product.
The present invention also provides above-mentioned preparation method of Chinese medicine, and wherein, the dosage form of said endo-medicine is a capsule, and its preparation method may further comprise the steps,
The first step with each component proportional mixing of said endo-medicine, adds determining alcohol with respect to 2～4 times of mixture qualities and is 70～80% ethanol, reflux 1～3 hour; Extract 2～3 times, merge extractive liquid, filters and obtains alcohol extract, alcohol extract concentrating under reduced pressure; Being recycled to does not have the alcohol flavor, filters the distilled water that the medicinal residues that obtain add 4～8 times of the mixture qualities formed with respect to each component of external used medicine again, decocts 1～3 hour, decocts 2～3 times; Filter respectively, merging filtrate gets the water extract, water extract concentrating under reduced pressure, and the concentrated solution of the alcohol extract that obtains with the front mixes; Further concentrating under reduced pressure removes and desolvates, and drying obtains and gets dry extract;
In second step, the dried cream that the first step is obtained is placed on pulverizes 1～2 hour in the super micron mill, pulverize, and sieves, and obtains 600 orders～800 purpose micropowders;
The 3rd step added Pulvis Talci, magnesium stearate successively in the micropowders of second step acquisition, carry out mixing and handle, and promptly got capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15～0.5: 0.15～0.5, and described capsule 's content is incapsulated in the housing, promptly get the capsule finished product.
Each component pharmacology is following in the endo-medicine:
The Rhizoma Anemarrhenae: bitter in the mouth, sweet, cold in nature, go into lung, stomach, kidney channel, the relieving restlessness of purging heat is arranged, the effect of nourshing Yin and drynsessmoistening prescription, clearing away lung-heat to relieve cough cures mainly fever caused by exogenous pathogenic factors, and hyperpyrexia is irritated, lung-heat type cough, interior-heat symptom such as quench one's thirst; Its bitter cold matter profit, the property sedimentation can heat clearing away, can promote the production of body fluid again, kindly controls warm pathogenic factor and goes into edema caused by disorder of QI, the intenseness of heat impairment of body fluid; Also be used to treat diabetes; Phlegm-heat obstructing in the lung and breathing heavily, the xeropulmonary cough, expectorant is few unfavorable; Hyperactivity of fire caused by deficiency of YIN, symptoms such as hyperactivity of deficient fire.
Ilex purpurea Hassk.[I.chinensis Sims: bitter in the mouth, cold in nature, return lung, large intestine, urinary bladder channel, have heat-clearing and toxic substances removing, the effect of promoting blood circulation and hemostasis is used for chronic tracheitis, pyelonephritis, bacillary dysentery; Burn and scald is controlled in external, ulcer of the lower limb, and leprelcosis, extra earning is hemorrhage, cold injury, mastitis, cards such as chapped skin.
Radix Ginseng Rubra: sweet in the mouth, little hardship, warm in nature, return spleen, lung, heart channel, have strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and the effect of nourishing qi to stop is used for weak body and prostration, cold extremities faint pulse, QI failing to control blood, metrostaxis; Heart failure, cards such as cardiogenic shock.
Rhizoma Zingiberis Preparatum: acrid in the mouth, hot in nature, return spleen, stomach, kidney, the heart, lung meridian, have warming spleen and stomach for dispelling cold, the effect of warming the meridian for stopping bleeding is used for Deficiency and coldness of spleen and stomach, and stomachache is vomited and diarrhoea, and tells the nosebleed metrorrhagia, yang deficiency card such as lose blood.
Rhizoma Imperatae: sweet in the mouth, cold in nature, go into lung, stomach, small intestine meridian, have cooling blood for hemostasis, the clearing away heat and promoting diuresis effect cures mainly heat in blood and spits blood, epistaxis spitting of blood, hematuria, metrorrhagia, purpura, calentura excessive thirst, gastric heat vomiting, dyspnea and cough due to lung-heat, the puckery pain of dribbling urination, edema, cards such as jaundice.
Herba Hedyotidis Diffusae: bitter in the mouth, sweet, cold in nature, go into the heart, liver, spleen, large intestine channel has heat-clearing and toxic substances removing; The effect of promoting diuresis to eliminate damp pathogen is used for dyspnea and cough due to lung-heat, laryngopharynx swelling and pain, acute appendicitis, furuncle and phyma skin infection, venom; The puckery pain of pyretic stranguria, edema, dysentery, enteritis, jaundice due to damp-heat, cards such as cancerous protuberance.
The Rhizoma Atractylodis Macrocephalae: sweet in the mouth, hardship, warm in nature, go into spleen, stomach warp, the spleen reinforcing promoting the circulation of QI is arranged, the dampness diuretic, strengthening superficial resistance to stop perspiration, the effect that activating the spleen is moisturized is mainly used in the feeling of fullness diarrhoea due to dysfunction of the spleen in transportation, the QI failing to transform into body fluid, the phlegm retention edema; The vexed lazy speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; Cards such as solid in the playing of deficiency of the spleen causing weakness of QI, sweating due to debility spontaneous perspiration.
Radix Angelicae Sinensis: sweet in the mouth, suffering, warm in nature, go into liver, the heart, spleen channel, enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, the effect of loosening bowel to relieve constipation is mainly used in blood and invigorates blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for cards such as blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
Arillus Longan: warm in nature, it is sweet to distinguish the flavor of, and has invigorating the heart and spleen, and the effect of nourishing blood to tranquillize the mind is used for cards such as insufficiency of vital energy and blood, severe palpitation, forgetful insomnia, blood deficiency and yellow complexion.
Herba Ecliptae: sweet in the mouth, acid, cold in nature, return liver, kidney channel, play not liver and kidney tonifying, the effect of cooling blood for hemostasis is used for having a dizzy spell due to the hepatic and renal YIN deficiency, blurring of vision, soreness of the waist and knees; Being suitable for the deficiency of YIN has hot person, is used for treating the haematemesis of the long-pending heat of stomach, symptoms such as the hemoptysis of injury of blood vessel of the lung by heat.
Radix Ophiopogonis: sweet in the mouth, little hardship, cold nature, GUIXIN, lung, stomach warp have YIN nourishing and the production of body fluid promoting, and the effect that lung moistening clears away heart-fire is used for dryness of the lung dry cough, and deficiency of YIN consumptive disease is coughed, the sore throat pharyngalgia, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, cards such as dryness of the intestine constipation.
Each component pharmacology is following in the external used medicine:
Radix Rhodiolae: sweet in the mouth, hardship, property is flat, returns lung, heart channel, has benefiting QI for activating blood circulation, and the effect of promoting blood circulation and relievining asthma is used for blood stasis due to qi deficiency, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, cards such as asthenia asthma.
Flos Carthami: warm in nature, acrid in the mouth is gone into, the heart, Liver Channel, has promoting blood circulation to restore menstrual flow, and the effect of stasis-dispelling and pain-killing is used for amenorrhea, dysmenorrhea, and lochia is not all right, lump in the abdomen mass in the abdomen, injury from falling down, skin infection disease such as swell and ache.
Herba Selaginellae: acrid in the mouth, property is flat, returns liver, heart channel, has the effect of promoting blood circulation to restore menstrual flow, is used for amenorrhea dysmenorrhea ， WEIJIA mass in the abdomen, and injury from falling down is spitted blood, and metrorrhagia is had blood in stool, cards such as proctoptosis.
Radix Tinosporae: bitter in the mouth, cold in nature, return lung, large intestine channel, have heat-clearing and toxic substances removing, the effect of relieving sore throat and pain is used for laryngopharynx swelling and pain, and the carbuncle furunculosis is had loose bowels, dysentery, cards such as gastral cavity abdomen burning pain.
Herba Swertiae Mileensis: bitter in the mouth, cold in nature, return liver, gallbladder, urinary bladder channel, have heat-clearing and toxic substances removing, the effect of dampness removing jaundice eliminating cures mainly jaundice due to damp-heat; The puckery pain of pyretic stranguria; Damp-heat dysentery; Leucorrhea with red and white discharge; Influenza; The malaria heating; Acute gastritis; Acute pharyngolaryngitis; Cards such as acute tonsillitis.
Rhizoma Dioscoreae Hypoglaucae: bitter in the mouth, property is flat, goes into liver, stomach, urinary bladder channel, and it is turbid to have a dampness removing, wind-damp dispelling, the effect of heat-clearing and toxic substances removing is used for stranguria marked by chyluria, nebulousurine, leukorrhagia, rheumatic arthralgia, soreness of waist and knee joint, bottom sore swollen toxin, cards such as eczema.
Herba Erigerontis: acrid in the mouth, little hardship, warm in nature, have expelling cold and relieving exterior syndrome, expelling wind and removing dampness, the effect of activating collaterals to relieve pain is used for headache due to common cold, toothache, stomachache, rheumatalgia, the paralysis that cerebrovascular accident causes, cards such as osteomyelitis.
Cortex Acanthopancis: acrid in the mouth, hardship, warm in nature, return liver, kidney channel, have wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening, the effect of the arteries and veins of invigorating blood circulation is used for anemofrigid-damp arthralgia; Lumbocrural pain; The muscles and bones flaccidity is soft; Children's's walking retardation in children; Body void is frail; Traumatic injury; Fracture; Edema; Foot gas; Uncontrolled urination card such as itch.
Herba Artemisiae Scopariae: bitter in the mouth, suffering, cold nature is gone into spleen, stomach, liver, gallbladder meridian, has clearing away damp-heat, and the effect of jaundice eliminating subcutaneous ulcer is used for jaundice, and no matter damp and hot YANG jaundice or cold-damp YIN jaundice all can be used, and also can be applicable to card such as oliguria with reddish urine due to fever disease in summer or the hygropyrexia.
Radix Scutellariae: bitter in the mouth, cold in nature, go into the heart, lung, stomach, gallbladder, large intestine channel, heat clearing and damp drying is arranged, eliminating fire and detoxication, antiabortive, the hemostatic effect is mainly used in diarrhoea, dysentery, jaundice, pyretic stranguria due to damp and hot; The cough due to lung-heat, thirsty pharyngalgia also can be used for excessive fetal movement due to heat in pregnancy, and the pyretic toxicity pathogenic fire is invaded the swollen card of carbuncle sore poison of excessive skin.
Borneolum Syntheticum: acrid in the mouth, hardship, cool in nature, go into the heart, lung meridian, have logical all keys, the stagnated fire of loosing goes nebula to make eye bright; The effect of reducing swelling and alleviating pain cures mainly the apoplexy locked mouth, calentura coma, infantile convulsion expectorant fan, deafness with qi stagnation, sore throat; Aphtha, otitis media, carbuncle, hemorrhoid, order is the nebula film also, cards such as enterobiasis.
Below adopt embodiment to specify embodiment of the present invention, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can make much of and implement according to this.
External used medicine cleanout fluid in the Chinese medicine of embodiment 1 the present invention preparation
Radix Rhodiolae 32g, Flos Carthami 58g, Herba Selaginellae 27g, Radix Tinosporae 21g, Herba Swertiae Mileensis 17g, Rhizoma Dioscoreae Hypoglaucae 14g, Herba Erigerontis 29g, Cortex Acanthopancis 14g, Herba Artemisiae Scopariae 16g, Radix Scutellariae 14g, Borneolum Syntheticum 9g are mixed, and the determining alcohol that adds 750g is 80% ethanol, and reflux 2 hours is extracted 3 times; Merge extractive liquid, filters and obtains alcohol extract, the alcohol extract concentrating under reduced pressure, and being recycled to does not have the alcohol flavor; Filter the distilled water that the medicinal residues that obtain add 1300g again, decocted 2 hours at every turn, decoct altogether 3 times, filter respectively; Merging filtrate gets the water extract, water extract concentrating under reduced pressure, and the concentrated solution of the alcohol extract that obtains with the front mixes further concentrating under reduced pressure; Remove and to desolvate, drying obtains and gets dry extract, and the dried cream that obtains is placed in the super micron mill pulverized 2 hours; Pulverize, sieve, obtain 800 purpose micropowders, the micropowders that obtains is dissolved in the distilled water of 1000g; Slow fire boiling 3 hours is filtered, and filtrating is cleanout fluid.
Endo-medicine tablet in the Chinese medicine of embodiment 2 the present invention preparation
With Rhizoma Anemarrhenae 68g, Ilex purpurea Hassk.[I.chinensis Sims 42g, Radix Ginseng Rubra 18g, Rhizoma Zingiberis Preparatum 33g, Rhizoma Imperatae 30g, Herba Hedyotidis Diffusae 10g, Rhizoma Atractylodis Macrocephalae 19g, Radix Angelicae Sinensis 18g, Arillus Longan 14g, Herba Ecliptae 16g, 14g mixing Radix Ophiopogonis, the determining alcohol that adds 850g is 80% ethanol, and reflux 2 hours is extracted merge extractive liquid, 3 times; Filter and obtain alcohol extract, the alcohol extract concentrating under reduced pressure, being recycled to does not have the alcohol flavor, filters the distilled water that the medicinal residues that obtain add 1500g again, decocts 2 hours at every turn; Decoct 3 times, filter respectively, merging filtrate gets the water extract, water extract concentrating under reduced pressure, and the concentrated solution of the alcohol extract that obtains with the front mixes; Further concentrating under reduced pressure removes and desolvates, and drying obtains and gets dry extract, and the dried cream that obtains is placed in the super micron mill pulverized 2 hours; Pulverize, sieve, obtain 800 purpose micropowders, with the micropowders that obtains, the starch of the microcrystalline Cellulose of adding 30g, 20g lactose, 30g; Sieve, mix homogeneously is granulated drying; Add the 3g magnesium stearate, granulate, tabletting is processed 1000.
Endo-medicine oral liquid in the Chinese medicine of embodiment 3 the present invention preparation
With Rhizoma Anemarrhenae 68g, Ilex purpurea Hassk.[I.chinensis Sims 42g, Radix Ginseng Rubra 18g, Rhizoma Zingiberis Preparatum 33g, Rhizoma Imperatae 30g, Herba Hedyotidis Diffusae 10g, Rhizoma Atractylodis Macrocephalae 19g, Radix Angelicae Sinensis 18g, Arillus Longan 14g, Herba Ecliptae 16g, 14g mixing Radix Ophiopogonis, the determining alcohol that adds 850g is 80% ethanol, and reflux 2 hours is extracted merge extractive liquid, 3 times; Filter and obtain alcohol extract, the alcohol extract concentrating under reduced pressure, being recycled to does not have the alcohol flavor, filters the distilled water that the medicinal residues that obtain add 1500g again; The each decoction 2 hours decocts 3 times, filters respectively, and merging filtrate gets the water extract; Water extract concentrating under reduced pressure, the concentrated solution of the alcohol extract that obtains with the front mixes, and further concentrating under reduced pressure is except that desolvating; Drying obtains and gets dry extract, and the dried cream that obtains is placed in the super micron mill pulverized 2 hours, pulverizes; Sieve, obtain 800 purpose micropowders, with the sucrose that adds 25g in the micropowders that obtains, 2g sodium benzoate; Mix homogeneously, the water that adds 1100g is again processed, sterilization, packing gets final product.
Endo-medicine capsule in the Chinese medicine of embodiment 4 the present invention preparation
With Rhizoma Anemarrhenae 68g, Ilex purpurea Hassk.[I.chinensis Sims 42g, Radix Ginseng Rubra 18g, Rhizoma Zingiberis Preparatum 33g, Rhizoma Imperatae 30g, Herba Hedyotidis Diffusae 10g, Rhizoma Atractylodis Macrocephalae 19g, Radix Angelicae Sinensis 18g, Arillus Longan 14g, Herba Ecliptae 16g, 14g mixing Radix Ophiopogonis, the determining alcohol that adds 850g is 80% ethanol, and reflux 2 hours is extracted 3 times; Merge extractive liquid, filters and obtains alcohol extract, the alcohol extract concentrating under reduced pressure, and being recycled to does not have the alcohol flavor; Filter the distilled water that the medicinal residues that obtain add 1500g again, decocted 2 hours at every turn, decoct 3 times, filter respectively; Merging filtrate gets the water extract, water extract concentrating under reduced pressure, and the concentrated solution of the alcohol extract that obtains with the front mixes further concentrating under reduced pressure; Remove and to desolvate, drying obtains and gets dry extract, and the dried cream that obtains is placed in the super micron mill pulverized 2 hours; Pulverize, sieve, obtain 800 purpose micropowders, in the micropowders that obtains, add 0.8g Pulvis Talci, 0.8g magnesium stearate successively; Carry out mixing and handle, promptly get capsule 's content, described capsule 's content is incapsulated in the housing, promptly get the capsule finished product.
Clinical experiment
1.1 basic clinical data
The acute pelvic inflammatory disease patient that accept for medical treatment this clinical experiment employing the court is totally 276 examples, is divided into 2 groups at random, and 200 examples are organized in treatment, 22～49 years old age, average 35.5 years old.5～16d, on average 10.5d are in hospital; Western medicine group 76 examples, 20～42 years old age, average 31 years old.Length of stay 7～22d, the diagnostic criteria of average 14.5d acute pelvic inflammatory disease is with reference to U.S. CDC (CDC) in 2002 diagnostic criteria.The Chinese medical discrimination typing is divided into noxious dampness and stops up Sheng type, warm stasis of blood junction type with reference to the Chinese medical discrimination standard of pelvic inflammatory disease in " new Chinese medicine clinical research guideline ".
Two groups of patients of clinical symptoms and sign all show obvious lower abdominal pain, aggravate the shiver with cold that occurs together simultaneously, heating when fatigue and sexual intercourse.Most of patient is with leucorrhoea grow in quantity and abnormal flavour.Mostly inducement is to suffer from cold menstrual period, unclean sexual intercourse or miscarriage etc.The obvious tenderness of the lower abdomen of having a medical check-up, peritoneal irritation sign is positive.The obvious tenderness of gynecologial examination palace body or adnexa, list or bilateral attachment area all thicken, tenderness or lay one's hand on and tenderness property enclosed mass.The whole cases of auxiliary examination all point out list or bilateral attachment area to thicken in various degree through ultrasound diagnosis, broadening or inflammatory mass, even hydrosalpinx (empyema) is arranged, the performance that pelvic hydrops exists.Laboratory inspection leukocyte increases.
1.2 Therapeutic Method
Matched group adopts intravenous drip ampicillin sulbactam+amikacin+metronidazole, and 1 time/d, 7～10d is 1 course of treatment, after the clothes antibiotic 7d after treatment of withdrawing the previous remark.
The treatment group adopts the endo-medicine oral liquid of the embodiment of the invention 3 preparations, each 100ml, every day 3 times; Adopt the external used medicine cleanout fluid of the mode external embodiment of the invention 1 preparation of coloclysis simultaneously; Promptly choose cleanout fluid 100ml, retention enema, temperature (40 ± 1) ℃; 1 time/d, 7～10d is 1 course of treatment.Patient's emptying bladder is got lateral position, slowly pours into warm medicinal liquid 100ml in the intestinal retention enema with enemator.
1.3 statistical method
Adopt SPSS 16.0 softwares to carry out statistical analysis.
1.4 evaluation criterion
Cure: the clinical symptoms sign all disappears, and B ultrasonic shows that list or bilateral adnexa recover normal, and inflammatory masses of pelvic cavity and inflammatory exudate all disappear.Take a turn for the better: the clinical symptoms sign is clearly better, and B ultrasonic shows that list or bilateral adnexa increase slightly and take a favorable turn, and inflammatory masses of pelvic cavity and inflammatory exudate dwindle or reduce >=and 1/3.Invalid: the clinical symptoms sign does not have improvement, and B ultrasonic shows that list or bilateral inflammatory masses of ovarian appendages inflammatory exudate do not have improvement.
1.5 the result sees table 1
Table 1 liang group patient clinical efficacy is (%) relatively
| Group | The example number | Cure | Take a turn for the better | Invalid | Total effective rate |
| The treatment group | 200 | 153 | 43 | 4 | 98％ |
| Matched group | 76 | 20 | 38 | 18 | 76.3％ |
Table 1 can find out that the curative effect of treatment group of the present invention will obviously be better than matched group.
This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any professional and technical personnel of being familiar with possibly utilize the technology contents of above-mentioned announcement to change or be modified as the equivalent embodiment of equivalent variations.But everyly do not break away from technical scheme content of the present invention, to any simple modification, equivalent variations and remodeling that above embodiment did, still belong to the protection domain of technical scheme of the present invention according to technical spirit of the present invention.
Claims (10)
1. a Chinese medicine of treating acute pelvic inflammatory disease is characterized in that, comprising: endo-medicine is the Rhizoma Anemarrhenae, Ilex purpurea Hassk.[I.chinensis Sims, Radix Ginseng Rubra, Rhizoma Zingiberis Preparatum, Rhizoma Imperatae, Herba Hedyotidis Diffusae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Arillus Longan, Herba Ecliptae, Radix Ophiopogonis;
External used medicine is Radix Rhodiolae, Flos Carthami, Herba Selaginellae, Radix Tinosporae, Herba Swertiae Mileensis, Rhizoma Dioscoreae Hypoglaucae, Herba Erigerontis, Cortex Acanthopancis, Herba Artemisiae Scopariae, Radix Scutellariae, Borneolum Syntheticum.
2. Chinese medicine as claimed in claim 1 is characterized in that: the ratio of weight and number of each component in the said Chinese medicine does,
Endo-medicine does, the Rhizoma Anemarrhenae 60～70 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 35～45 weight portions, Radix Ginseng Rubra 10～20 weight portions, Rhizoma Zingiberis Preparatum 25～35 weight portions, Rhizoma Imperatae 22～32 weight portions, Herba Hedyotidis Diffusae 6～12 weight portions, the Rhizoma Atractylodis Macrocephalae 13～21 weight portions, Radix Angelicae Sinensis 14～20 weight portions, Arillus Longan 8～16 weight portions, Herba Ecliptae 12～18 weight portions, Radix Ophiopogonis 9～15 weight portion.
3. according to claim 1 or claim 2 Chinese medicine is characterized in that: the ratio of weight and number of each component in the said Chinese medicine does,
External used medicine is Radix Rhodiolae 25～35 weight portions, Flos Carthami 50～60 weight portions, Herba Selaginellae 20～30 weight portions, Radix Tinosporae 16～22 weight portions, Herba Swertiae Mileensis 12～18 weight portions, Rhizoma Dioscoreae Hypoglaucae 10～16 weight portions, Herba Erigerontis 24～30 weight portions, Cortex Acanthopancis 8～15 weight portions, Herba Artemisiae Scopariae 12～18 weight portions, Radix Scutellariae 10～16 weight portions, Borneolum Syntheticum 6～10 weight portions.
4. like the described Chinese medicine of claim 1 to 3, it is characterized in that: the ratio of weight and number of each component in the said Chinese medicine does,
Endo-medicine does, the Rhizoma Anemarrhenae 65～70 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 40～45 weight portions, Radix Ginseng Rubra 15～20 weight portions, Rhizoma Zingiberis Preparatum 30～35 weight portions, Rhizoma Imperatae 28～32 weight portions, Herba Hedyotidis Diffusae 8～12 weight portions, the Rhizoma Atractylodis Macrocephalae 17～21 weight portions, Radix Angelicae Sinensis 16～20 weight portions, Arillus Longan 12～16 weight portions, Herba Ecliptae 15～18 weight portions, Radix Ophiopogonis 12～15 weight portion.
5. like the described Chinese medicine of claim 1 to 4, it is characterized in that: the ratio of weight and number of each component in the said Chinese medicine does,
External used medicine is Radix Rhodiolae 30～35 weight portions, Flos Carthami 55～60 weight portions, Herba Selaginellae 25～30 weight portions, Radix Tinosporae 20～22 weight portions, Herba Swertiae Mileensis 16～18 weight portions, Rhizoma Dioscoreae Hypoglaucae 13～16 weight portions, Herba Erigerontis 27～30 weight portions, Cortex Acanthopancis 12～15 weight portions, Herba Artemisiae Scopariae 15～18 weight portions, Radix Scutellariae 12～16 weight portions, Borneolum Syntheticum 8～10 weight portions.
6. like the described preparation method of Chinese medicine of claim 1 to 5, it is characterized in that:
The dosage form of the external used medicine of said Chinese medicine is a cleanout fluid, and its preparation method may further comprise the steps,
The first step with each component proportional mixing of said external used medicine, adds determining alcohol with respect to 2～4 times of mixture qualities and is 70～80% ethanol, reflux 1～3 hour; Extract 2～3 times, merge extractive liquid, filters and obtains alcohol extract, alcohol extract concentrating under reduced pressure; Being recycled to does not have the alcohol flavor, filters the distilled water that the medicinal residues that obtain add 4～8 times of the mixture qualities formed with respect to each component of external used medicine again, decocts 1～3 hour, decocts 2～3 times; Filter respectively, merging filtrate gets the water extract, water extract concentrating under reduced pressure, and the concentrated solution of the alcohol extract that obtains with the front mixes; Further concentrating under reduced pressure removes and desolvates, and drying obtains and gets dry extract;
In second step, the dried cream that the first step is obtained is placed on pulverizes 1～2 hour in the super micron mill, pulverize, and sieves, and obtains 600 orders～800 purpose micropowders;
The 3rd step was dissolved in the micropowders that obtains in the distilled water with respect to 3～5 times of its quality, and slow fire boiling 2～4 hours is filtered, and filtrating is cleanout fluid.
7. like the described preparation method of Chinese medicine of claim 1 to 5, it is characterized in that:
The method for preparing of the endo-medicine of said Chinese medicine may further comprise the steps,
The first step with each component proportional mixing of said endo-medicine, adds determining alcohol with respect to 2～4 times of mixture qualities and is 70～80% ethanol, reflux 1～3 hour; Extract 2～3 times, merge extractive liquid, filters and obtains alcohol extract, alcohol extract concentrating under reduced pressure; Being recycled to does not have the alcohol flavor, filters the distilled water that the medicinal residues that obtain add 4～8 times of the mixture qualities formed with respect to each component of external used medicine again, decocts 1～3 hour, decocts 2～3 times; Filter respectively, merging filtrate gets the water extract, water extract concentrating under reduced pressure, and the concentrated solution of the alcohol extract that obtains with the front mixes; Further concentrating under reduced pressure removes and desolvates, and drying obtains and gets dry extract;
In second step, the dried cream that the first step is obtained is placed on pulverizes 1～2 hour in the super micron mill, pulverize, and sieves, and obtains 600 orders～800 purpose micropowders;
In the 3rd step, the method for preparing with the micropowders of second step acquisition is pressed regular dosage form is prepared into various dosage forms.
8. preparation method of Chinese medicine as claimed in claim 7 is characterized in that:
When the dosage form of said endo-medicine was tablet, said the 3rd step was specially the micropowders that second step was obtained, and added microcrystalline Cellulose with respect to 0.1～0.3 times of its quality, 0.05～0.15 times of lactose, 0.1～0.3 times starch 60g; Sieve, mix homogeneously is granulated; Drying adds with respect to 0.005～0.05 times of magnesium stearate of micropowders quality, granulate; Tabletting is processed 1000.
9. preparation method of Chinese medicine as claimed in claim 7 is characterized in that:
When the dosage form of said endo-medicine is oral liquid; Said the 3rd step is specially in the micropowders that obtains in second step and adds the sucrose with respect to 0.05～0.1 times of its quality; 0.005～0.01 times of sodium benzoate, mix homogeneously adds with respect to the water of 3～5 times of micropowders quality again and processes; Sterilization, packing gets final product.
10. preparation method of Chinese medicine as claimed in claim 7 is characterized in that:
When the dosage form of said endo-medicine was capsule, said the 3rd step was specially in the micropowders that obtains in second step and adds Pulvis Talci, magnesium stearate successively, carries out mixing and handles, and promptly gets capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15～0.5: 0.15～0.5, and described capsule 's content is incapsulated in the housing, promptly get the capsule finished product.
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| CN103446476A (en) * | 2013-08-14 | 2013-12-18 | 马靖已 | Traditional Chinese medicine composition for treating pelvic inflammation |
| CN104623216A (en) * | 2013-11-20 | 2015-05-20 | 蒋梅 | Drug for treating chronic pelvic inflammatory disease |
| CN104922498A (en) * | 2015-05-20 | 2015-09-23 | 王震 | Traditional Chinese medicine for treating pelvic inflammation |
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