CN105168746B - A kind of nursing medicine for the treatment of infantile oxyuriasis and preparation method thereof - Google Patents
A kind of nursing medicine for the treatment of infantile oxyuriasis and preparation method thereof Download PDFInfo
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- CN105168746B CN105168746B CN201510545956.4A CN201510545956A CN105168746B CN 105168746 B CN105168746 B CN 105168746B CN 201510545956 A CN201510545956 A CN 201510545956A CN 105168746 B CN105168746 B CN 105168746B
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Abstract
The invention belongs to medical art, be specifically related to a kind of nursing medicine for the treatment of infantile oxyuriasis and preparation method thereof.The components such as described nursing medicine is by Fructus Ulmus preparatium, Rhizoma Osmundae, Poria, Rhizoma Dioscoreae, the Fructus Kochiae, Radix Gentianae, Herba Portulacae, Radix Paeoniae Rubra form.Nursing medicine of the present invention has killing parasites for relieving itching, spleen benefiting and stimulating the appetite, the significant curative effect of heat-clearing and toxic substances removing, disease enterobiasis is disturbed to the especially insufficiency of the spleen worm of enterobiasis and has extremely strong pertinent nursing effect, through clinical practice checking, its determined curative effect, onset is rapid, there is not toxic and side effects and untoward reaction, can be used as nursing for treating enterobiasis particularly insufficiency of the spleen worm disturb the active drug of disease enterobiasis.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of nursing medicine for the treatment of infantile oxyuriasis and preparation method thereof.
Background technology
Enterobiasis is food owing to eating band pinworm egg or causes owing to sucking the bad habits such as finger, is one of Childhood common Enterozoa disease.Because gradient of infection is different, can heterotopic parasitism be there is again, therefore clinically can non-evident sympton, or show different sings and symptomses.Modal performance is perianal itch, especially to attach most importance to night.Can gastrointestinal dysfunction be caused during severe infection, occur vomiting, diarrhoea, heating, stomachache etc.This disease is everlasting in child and is mutually propagated, and repeated infection, makes infant sleep disorder, and spirit is irritated, and diet is abnormal, serious shadow children's health.If cured not in time, the female worm of minority can enter anus again or pierce youngest daughter's vagina, urethra heterotopic parasitism infection, can cause the diseases such as urethritis, vaginitis, endometritis, salpingitis.
The traditional Chinese medical science is thought, enterobiasis etiology and pathology is unhygienic diet, retention of damp-heat in the interior, and taste lose strong, and consumption of a specified duration hinders vigour.Ming Dynasty's " medical science six wants worm door " is said " damp and hot for a long time strongly fragrant, then infested "." by few wind syndrome caused by excess of YANG originally, retention and fumigation of damp-heat inside the body forms worm ", " hungry full inappropriate, the middle part of gastric cavity deficiency of vital energy, damp and hot mistake fortune, therefore raw parasites " are said by the Qing Dynasty " the logical worm of Zhang Shi doctor ".Chinese traditional treatment enterobiasis, long and rich experience, and modern clinic is still widely used.And treatment by Chinese herbs has dialectical treating, multipath onset, the feature that adverse reaction rate is low, late result is good, therefore in conjunction with modern Chinese medicine theory of development, from improving curative effect of medication, reducing the angle of side effect and relapse rate, the Chinese medicine preparation of the treatment enterobiasis that development curative effect is more definite is necessary.
Summary of the invention
The invention provides a kind of nursing medicine for the treatment of enterobiasis, its safety is high, effective, can be used as nursing enterobiasis particularly insufficiency of the spleen worm disturb the ideal medicament of disease enterobiasis.Chinese medicine preparation prescription of the present invention is rigorous, and compatibility science is easy to prepare, and patient compliance is good, and toxic and side effects is little, clinic promotion and application.
For achieving the above object, technical scheme provided by the invention is the nursing medicine of described treatment enterobiasis, and the composition and ratio of its crude drug is: Fructus Ulmus preparatium 12-16g, Rhizoma Osmundae 8-12g, Poria 8-10g, Rhizoma Dioscoreae 10-12g, Fructus Kochiae 6-8g, Radix Gentianae 4-6g, Herba Portulacae 8-10g, Radix Paeoniae Rubra 8-10g.
The preferred technical scheme of the present invention is, nursing medicine of the present invention is obtained by the material medicine of following weight proportion: Fructus Ulmus preparatium 14g, Rhizoma Osmundae 10g, Poria 9g, Rhizoma Dioscoreae 11g, Fructus Kochiae 7g, Radix Gentianae 5g, Herba Portulacae 9g, Radix Paeoniae Rubra 9g.
Present invention also offers the preparation method of described nursing medicine, specifically comprise: take above Chinese medicine component according to aforesaid weight and pulverize respectively, decoct 2 times after soaking 3h, add medicine gross weight 6-8 water doubly at every turn, decoct 2-4 hour, merge decoction liquor, filter; When filtrate concentrates 75 DEG C, relative density is the extractum of 1.11-1.21, and cold drying, pulverized 100-120 mesh sieve, adds pharmaceutically acceptable excipients make clinical acceptable dosage form through normal process steps.
Nursing medicine of the present invention can be prepared into oral formulations, as tablet, capsule or granule, is preferably granule.
The present invention also asks the purposes protecting above-mentioned nursing medicine in the medicine of preparation treatment enterobiasis.Particularly the purposes in the medicine of disease enterobiasis is disturbed in described nursing pharmaceutical preparation the insufficiency of the spleen worm of preparation treatment.
Present invention also offers the clinical observation of described nursing Drug therapy enterobiasis:
1, diagnostic criteria:
Diagnostic criteria according to enterobiasis in " enterobiasis Chinese traditional medical diagnose guide " is formulated: perianal itch, night, more so crissum or people just saw pinworm, and night grinds one's teeth in sleep, inappetence, shallow complexion, emaciated physique, stomachache, dysphoria, insomnia, frequent micturition, the symptoms such as the enuresis.Girl can have pruritus prejudice external genitalia, external genitalia rubescent, can show the complication such as vulvitis, vaginitis, urethritis, anus erosion in mountain.
Syndrome Differentiation of Traditional Chinese Medicine is that insufficiency of the spleen worm disturbs card, and disease is seen: pruritus ani, uneasy sleeping at night, loss of appetite, emaciated physique, light red tongue.
2, physical data:
120 routine infants all accord with enterobiasis diagnostic criteria in " enterobiasis Chinese traditional medical diagnose guide ".Wherein man 68 example, female 52 example; Wherein less than 3 years old 12 example, 3 ~ 7 years old 85 example, 7 ~ 14 years old 23 example, 5.4 years old mean age; Merge perianal infection, rotten to the corn sepage, the example in eczema sample shower 45.Be divided into treatment group and matched group at random, each 60 examples, the physical data such as 2 groups of case ages, courses of disease, through statistical procedures there was no significant difference, have comparability.
3, Therapeutic Method:
Matched group: take " zental " sheet treatment that SmithKline Pharmaceuticals Ltd of Tianjin Sino-U.S. produces, every sheet 200mg, 3-5 year 200mg/ time, 6-8 year 400mg/ time, evening every day auf nuechternen Magen einnehmen 1 time, a course for the treatment of on the 4th.
Treatment group: take granule prepared by embodiment 3, containing crude drug amount 0.5g, every day 2 times, each 1 bag, takes, a course for the treatment of on the 4th for every bag after meal half an hour.
Be eczema sample shower for the rotten to the corn sepage of perianal infection, be separately applied to crissum with 10% sulfur ointment.
The urine smell of patient's diet, pungent, stimulating food during nursing for treating, as fish and shrimp, Carnis Canitis, Carnis caprae seu ovis, Sanguis sus domestica, Folium Allii tuberosi, Herba Alii fistulosi, Bulbus Allii, Fructus Capsici etc.; Trousers should be loose, and keep dry and comfortable, pruritus should not be scratched; Every morning cleans skin around the rectum with soap warm water, and the underwear pants changed should steaming and decocting or the rear Exposure to Sunlight parasite killing of boiled water immersion.
4, the standard of curative effect evaluation:
Cure: transference cure, continuous 3 hinge anuses are wiped method mirror and are picked up and do not find worm's ovum;
Take a turn for the better: symptom is improved, and microscopy can find worm's ovum;
Invalid: symptom is without improvement, and microscopy finds worm's ovum.
Total effective rate=cure rate+obvious effective rate.
6, therapeutic effect:
120 routine patients, without coming off, exiting case, all complete clinical observation.
After the course for the treatment of, observation and comparison is carried out to the therapeutic effect of two groups of patients, the routine patient of matched group 60,16 examples are cured, and 23 examples take a turn for the better, 21 examples are invalid, total effective rate 65%, the routine patient for the treatment of group 60,35 examples are cured, 21 examples take a turn for the better, 4 examples are invalid, and total effective rate 93.3%, treatment group therapeutic effect is obviously better than matched group.Concrete clinical efficacy the results are shown in following table.
Two groups of Clinical efficacy comparisons
| Group | n | Cure | Take a turn for the better | Invalid | Total effective rate |
| Matched group | 60 | 16 | 23 | 22 | 65％ |
| Treatment group | 60 | 35 | 21 | 4 | 93.3％ |
The above results shows, after enterobiasis patient the application of the invention nursing Drug therapy, symptom can significantly improve, and in addition, treatment group before the treatment rear body weight, heart rate, blood pressure is showed no obvious change.Treatment group does not find obvious adverse events in whole therapeutic process.Illustrate that nursing medicine of the present invention particularly disturbs determined curative effect in disease enterobiasis the insufficiency of the spleen worm of nursing nursing enterobiasis thus, safety is high, can be used as the nursing medicine for the treatment of enterobiasis, is worth studying and applying further.
The present invention, relative to prior art, has following clear superiority:
Nursing medicament composing prescription of the present invention mainly develops according to the pathogenic characteristic of enterobiasis patient, Fructus Ulmus preparatium in side, Rhizoma Osmundae, eliminating stagnated food and killing intestinal worms; Poria, Rhizoma Dioscoreae, strengthening the spleen and nourishing the stomach, mind tranquilizing and the heart calming; The Fructus Kochiae, Radix Gentianae, heat clearing away, damp eliminating, antipruritic; Herba Portulacae, Radix Paeoniae Rubra, heat-clearing and toxic substances removing, cooling blood for hemostasis, repairing ulcer face.All medicines share has killing parasites for relieving itching, spleen benefiting and stimulating the appetite, the significant curative effect of heat-clearing and toxic substances removing, and disturbing disease enterobiasis to the especially insufficiency of the spleen worm of enterobiasis has extremely strong pertinent nursing effect.Through clinical practice checking, its determined curative effect, mild in medicine property and, do not occur toxic and side effects and untoward reaction, safety coefficient is high.
Further, in nursing medicine of the present invention, the function of each crude drug cures mainly:
Fructus Ulmus preparatium is pungent, bitter, flat.Eliminating stagnated food and killing intestinal worms.For infantile malnutrition, ascariasis, enterobiasis.
Rhizoma Osmundae, bitter, cool.Enter liver, stomach warp.Kill ascarid, silk ribbon, pinworm, heat clearing away, removing toxic substances, removing heat from blood, hemostasis.Control anemopyretic cold.Warm macule, spits blood, epistaxis, discharging fresh blood stool, dysentery, metrorrhagia, leukorrhagia, skin infection, hematuria, menorrhagia, and knife injury is hemorrhage, ascarid, rich worm, taeniasis, artificial abortion, postpartum hemorrhage.
Poria is sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Rhizoma Dioscoreae, sweet, flat.Enter lung, spleen, kidney channel.Spleen invigorating, tonifying the lung, reinforces the kidney, benefit essence.Control diarrhea due to hypofunction of the spleen, chronic dysentery, cough due to consumptive disease, quench one's thirst, seminal emission, leukorrhagia, frequent micturition.Spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.Breath with cough for insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat quench one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.
The Fructus Kochiae is pungent, bitter, cold.Return kidney, urinary bladder channel.Clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.For difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.
Radix Gentianae, bitter, cold.Return liver, gallbladder meridian.Heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire.For jaundice due to damp-heat, swelling of the vulva pudendal pruritus, leukorrhagia, persistent erection of the penis, eczema pruritus, conjunctival congestion, deaf, hypochondriac pain, bitter taste, convulsion with spasms.
Herba Portulacae, acid, cold.Return liver, large intestine channel.Heat-clearing and toxic substances removing, cooling blood for hemostasis.For toxic-heat and blood stasis, carbuncle furuncle, eczema, erysipelas, snake bite and insect sting, has blood in stool, hemorrhoidal bleeding, metrostaxis.
Radix Paeoniae Rubra, bitter, be slightly cold.Return Liver Channel.Clearing away heat and cooling blood, eliminating stasis to stop pain.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea ， mass in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle skin infection.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, but the present invention is not limited only to following specific embodiment.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1 tablet
The each raw material of the present invention is taken: Fructus Ulmus preparatium 14g, Rhizoma Osmundae 10g, Poria 9g, Rhizoma Dioscoreae 11g, Fructus Kochiae 7g, Radix Gentianae 5g, Herba Portulacae 9g, Radix Paeoniae Rubra 9g by following weight proportion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid weight to pulverize respectively, decoct 2 times after soaking 3h, add the water of medicine gross weight 6 times at every turn, decoct 2 hours, merge decoction liquor, filter; When filtrate concentrates 75 DEG C, relative density is the extractum of 1.11-1.21, and cold drying, pulverized 100-120 mesh sieve, adds pharmaceutically acceptable excipients make tablet through normal process steps.
When using the present invention to nurse with Drug therapy enterobiasis, take prepared tablet, every sheet contains crude drug amount 0.15g, every day 2 times, each 2-4 sheet, one after each meal.
Embodiment 2 capsule
The each raw material of the present invention is taken: Fructus Ulmus preparatium 14g, Rhizoma Osmundae 10g, Poria 9g, Rhizoma Dioscoreae 11g, Fructus Kochiae 7g, Radix Gentianae 5g, Herba Portulacae 9g, Radix Paeoniae Rubra 9g by following weight proportion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid weight to pulverize respectively, decoct 2 times after soaking 3h, add the water of medicine gross weight 7 times at every turn, decoct 3 hours, merge decoction liquor, filter; When filtrate concentrates 75 DEG C, relative density is the extractum of 1.11-1.21, and cold drying, pulverized 100-120 mesh sieve, adds pharmaceutically acceptable excipients make capsule through normal process steps.
When using the present invention to nurse with Drug therapy enterobiasis, take prepared capsule, every contains crude drug amount 0.15g, and every day 2 times, each 2-4 grain, takes after meal half an hour.
Embodiment 3 granule
The each raw material of the present invention is taken: Fructus Ulmus preparatium 14g, Rhizoma Osmundae 10g, Poria 9g, Rhizoma Dioscoreae 11g, Fructus Kochiae 7g, Radix Gentianae 5g, Herba Portulacae 9g, Radix Paeoniae Rubra 9g by following weight proportion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid weight to pulverize respectively, decoct 2 times after soaking 3h, add the water of medicine gross weight 6 times at every turn, decoct 4 hours, merge decoction liquor, filter; When filtrate concentrates 75 DEG C, relative density is the extractum of 1.11-1.21, and cold drying, pulverized 100-120 mesh sieve, adds pharmaceutically acceptable excipients make granule through normal process steps.
When using Chinese medicine preparation of the present invention to treat enterobiasis, take prepared granule, containing crude drug amount 0.5g, every day 2 times, each 1 bag, take half an hour after meal for every bag.
Embodiment 4 granule
The each raw material of the present invention is taken: Fructus Ulmus preparatium 12g, Rhizoma Osmundae 8g, Poria 8g, Rhizoma Dioscoreae 10g, Fructus Kochiae 6g, Radix Gentianae 4g, Herba Portulacae 8g, Radix Paeoniae Rubra 8g by following weight proportion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid weight to pulverize respectively, decoct 2 times after soaking 3h, add the water of medicine gross weight 6 times at every turn, decoct 2 hours, merge decoction liquor, filter; When filtrate concentrates 75 DEG C, relative density is the extractum of 1.11-1.21, and cold drying, pulverized 100-120 mesh sieve, adds pharmaceutically acceptable excipients make granule through normal process steps.
When using Chinese medicine preparation of the present invention to treat enterobiasis, take prepared granule, containing crude drug amount 0.5g, every day 2 times, each 1 bag, take half an hour after meal for every bag.
Embodiment 5 granule
The each raw material of the present invention is taken: Fructus Ulmus preparatium 16g, Rhizoma Osmundae 12g, Poria 10g, Rhizoma Dioscoreae 12g, Fructus Kochiae 8g, Radix Gentianae 6g, Herba Portulacae 10g, Radix Paeoniae Rubra 10g by following weight proportion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid weight to pulverize respectively, decoct 2 times after soaking 3h, add the water of medicine gross weight 8 times at every turn, decoct 4 hours, merge decoction liquor, filter; When filtrate concentrates 75 DEG C, relative density is the extractum of 1.11-1.21, and cold drying, pulverized 100-120 mesh sieve, adds pharmaceutically acceptable excipients make granule through normal process steps.
When using Chinese medicine preparation of the present invention to treat enterobiasis, take prepared granule, containing crude drug amount 0.5g, every day 2 times, each 1 bag, take half an hour after meal for every bag.
Claims (7)
1. treat a nursing medicine for enterobiasis, it is characterized in that, the composition and ratio of its crude drug is: Fructus Ulmus preparatium 12-16g, Rhizoma Osmundae 8-12g, Poria 8-10g, Rhizoma Dioscoreae 10-12g, Fructus Kochiae 6-8g, Radix Gentianae 4-6g, Herba Portulacae 8-10g, Radix Paeoniae Rubra 8-10g.
2. nursing medicine as claimed in claim 1, it is characterized in that, the composition and ratio of its crude drug is: Fructus Ulmus preparatium 14g, Rhizoma Osmundae 10g, Poria 9g, Rhizoma Dioscoreae 11g, Fructus Kochiae 7g, Radix Gentianae 5g, Herba Portulacae 9g, Radix Paeoniae Rubra 9g.
3. a kind of nursing medicine for the treatment of enterobiasis as claimed in claim 1 or 2, it is characterized in that, the preparation method of described pharmaceutical composition comprises following steps: take above Chinese medicinal components according to aforesaid weight and pulverize respectively, decoct 2 times after soaking 3h, add medicine gross weight 6-8 water doubly at every turn, decoct 2-4 hour, merge decoction liquor, filter; When filtrate concentrates 75 DEG C, relative density is the extractum of 1.11-1.21, and cold drying, pulverized 100-120 mesh sieve, adds pharmaceutically acceptable excipients make clinical acceptable dosage form through normal process steps.
4. a kind of nursing medicine for the treatment of enterobiasis as claimed in claim 3, it is characterized in that, described nursing medicine can be made into oral formulations.
5. a kind of nursing medicine for the treatment of enterobiasis as claimed in claim 4, it is characterized in that, described oral formulations is tablet, capsule or granule.
6. the purposes of nursing medicine as claimed in claim 1 or 2 in the nursing medicine of preparation treatment enterobiasis.
7. the purposes in the nursing medicine of disease enterobiasis disturbed by nursing medicine as claimed in claim 1 or 2 the insufficiency of the spleen worm of preparation treatment.
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| CN102233110B (en) * | 2010-04-28 | 2012-08-22 | 丁奇 | Chinese medicinal paste for treating enterobiasis and preparation method thereof |
| CN103417883A (en) * | 2013-08-06 | 2013-12-04 | 天津太平洋制药有限公司 | Medicine for treating pinworm |
| CN104042988A (en) * | 2014-06-11 | 2014-09-17 | 孟兆玉 | Preparation for treating eczema and preparation method thereof |
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Effective date of registration: 20171208 Address after: Nanjing road 226100 Jiangsu Sijia town of Haimen city of Nantong province No. 78 Patentee after: HAIMEN RUITAI TEXTILE TECHNOLOGY Co.,Ltd. Address before: 202, room 1, building 2, No. 131 Ping'an Road, Lanshan District, Shandong, Linyi, 276000 Patentee before: Liu Haiyan |