CN113181323A

CN113181323A - Traditional Chinese medicine composition for treating nephrotic syndrome and application thereof

Info

Publication number: CN113181323A
Application number: CN202110337647.3A
Authority: CN
Inventors: 何灵芝; 吴满满; 甘安平; 朱秀芳; 张缘
Original assignee: First Affiliated Hospital of ZCMU
Current assignee: First Affiliated Hospital of ZCMU
Priority date: 2021-03-30
Filing date: 2021-03-30
Publication date: 2021-07-30

Abstract

The invention discloses a traditional Chinese medicine composition for treating nephrotic syndrome and application thereof, wherein the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 12-20 parts of radix rehmanniae recen, 12-15 parts of yam, 9-12 parts of dogwood, 6-12 parts of cinnamon, 5-15 parts of prepared monkshood, 9-15 parts of medicinal cyathula root, 9-12 parts of earthworm, 9-12 parts of morinda officinalis and 3-9 parts of baked ginger. The traditional Chinese medicine composition provided by the invention adopts an external acupoint application form, is administered through skin, promotes medicine absorption by applying, realizes acupoint stimulation, achieves the effects of warming kidney and strengthening spleen, promoting blood circulation and removing obstruction in channels, and inducing diuresis to alleviate edema, further reduces proteinuria, improves hypoproteinemia, reduces edema, improves the immune function of a patient, and achieves a treatment effect. The medicine is safe, has no toxic or side effect, is simple and convenient to operate, has direct curative effect, low price and good patient compliance.

Description

Traditional Chinese medicine composition for treating nephrotic syndrome and application thereof

(I) technical field

The invention relates to a traditional Chinese medicine composition for treating nephrotic syndrome and an application method thereof.

(II) background of the invention

Nephrotic Syndrome (NS) is a common clinical sign of increased glomerular basement membrane permeability caused by a variety of causes, and is clinically manifested mainly as: high amounts of urine protein, high edema, hyperlipidemia, and hypoproteinemia (i.e., "high, low"). The large amount of urine protein, i.e. 24 hours urine protein quantification > 3.5 g. Hypoproteinemia, i.e., plasma albumin less than 30 g/L. NS can be divided into attack and remission. Modern medicine is generally used therapeutically to control the progression of the disease by helping patients to improve their diet, induce diuresis to reduce edema, reduce urinary protein, hormones, immunosuppressants, and the like. However, the hormone and immunosuppressant drugs have unique effects and use methods, and have more side effects, such as body changes of lunar face, buffalo back and the like and changes of mental symptoms, so that the economic, physical and psychological stresses of patients are increased, the social adaptation ability is reduced, negative emotions such as anxiety and depression are increased, and the life quality of the patients is further reduced.

The immune function of a patient with nephrotic syndrome is generally low, the patient is easy to relapse after being relieved, the kidney burden is increased and the kidney function is damaged after the patient relapses for many times, severe patients can also induce fatal complications such as acute renal failure, cardiac failure, severe infection, thromboembolic syndrome and the like, the patient needs to be maintained by dialysis in the later period, and even the critical patient threatens the life at any time.

The external treatment method of traditional Chinese medicine is one of the traditional Chinese medicine treatment methods, just as in Ri \28729andJ-Wen: the theory of external treatment, i.e. the theory of internal treatment, the medicine for external treatment, i.e. the medicine for internal treatment, and the different Fa Er, well elaborates the principle of external treatment of internal diseases by external treatment in traditional Chinese medicine. Therefore, on the basis of the conventional treatment of the original western medicine, the traditional Chinese medicine is adopted for treating the nephropathy by external application, so that the kidney injury can be relieved, the burden of the digestive tract can be relieved, the immunologic function of a patient can be improved, and the traditional Chinese medicine has no toxic or side effect, so that the traditional Chinese medicine is consistently pursued by the masses of medicine.

In conclusion, the problem to be solved at present is to find a formula for effectively treating nephrotic syndrome by traditional Chinese medicine external treatment.

Disclosure of the invention

The invention aims to provide a traditional Chinese medicine composition for treating nephrotic syndrome and an application method thereof.

The technical scheme adopted by the invention is as follows:

the invention provides a traditional Chinese medicine composition for treating nephrotic syndrome, which is prepared from the following raw materials in parts by weight: 12-20 parts of radix rehmanniae recen, 12-15 parts of yam, 9-12 parts of dogwood, 6-12 parts of cinnamon, 5-15 parts of prepared monkshood, 9-15 parts of medicinal cyathula root, 9-12 parts of earthworm, 9-12 parts of morinda officinalis and 3-9 parts of baked ginger.

In one embodiment of the invention, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15 parts of radix rehmanniae recen, 15 parts of Chinese yam, 10 parts of dogwood, 10 parts of cinnamon, 10 parts of prepared aconite root, 10 parts of medicinal cyathula root, 10 parts of earthworm, 10 parts of morinda officinalis and 5 parts of baked ginger.

In one embodiment of the invention, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20 parts of radix rehmanniae recen, 15 parts of Chinese yam, 12 parts of dogwood, 12 parts of cinnamon, 15 parts of prepared aconite root, 15 parts of medicinal cyathula root, 12 parts of earthworm, 12 parts of morinda officinalis and 9 parts of baked ginger.

In another embodiment of the invention, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 12 parts of radix rehmanniae recen, 12 parts of yam, 9 parts of dogwood, 6 parts of cinnamon, 5 parts of prepared aconite root, 9 parts of medicinal cyathula root, 9 parts of earthworm, 9 parts of morinda officinalis and 3 parts of baked ginger.

The invention also provides a patch prepared from the traditional Chinese medicine composition, which is prepared by the following method: grinding the raw materials into powder according to the formula amount, mixing, adding rice vinegar and honey, and blending into paste, wherein force is required to be applied uniformly during blending to ensure that the powder is fully mixed with the honey and the rice vinegar; the prepared medicinal paste is required to be neither dry nor wet, and neither flowable nor caking, and an appropriate amount of medicinal paste is taken out and respectively kneaded into spheres with diameters of 0.6-1.0cm to be used as traditional Chinese medicine lumps; placing the prepared Chinese medicinal ball on a patch of 2cm × 2cm to obtain patch; the mass ratio of the rice vinegar to the honey is 1.5: 1, the total adding amount of the rice vinegar and the honey is 1/4-1/3 of the total mass of the medicine.

The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for treating nephrotic syndrome, wherein the medicine is in a form of application.

The application method of the invention comprises the following steps: respectively sticking on Shenshu (double side), Jingmen (double side), Guanyuan, moisture, Pishu (double side), Geshu (double side), Zusanli (double side), Fuliu (double side), Taixi (double side); the plaster is applied for 2 hours for the first time, then each time is 4 hours, and the plaster is applied once every 7 days for 8 times as a course of treatment; if itching, pain, swelling, etc. appear, it can be removed in advance to avoid blister and desquamation; can be used for normal bath after 6 hours; it is not suitable for eating uncooked, cold, greasy, spicy food in the same day. Rest, wind-cold prevention and emotion regulation; after being applied, if skin vesicles appear on the local part, the skin vesicles can be absorbed by the patient without treatment. If the blister is large, the local protection is enhanced, the infection is avoided, the iodophor is used for disinfection, the liquid in the blister is removed, sterile gauze is covered, the drying is kept, and the bathing is forbidden within 6 hours after the application.

The traditional Chinese medicine composition and the selection of the acupuncture points provided by the invention are formed by accumulating more than 30 years of clinical experience of famous traditional Chinese medicine experts, and the clinical verification for many years proves that the traditional Chinese medicine composition has the advantages of definite effect, simplicity and convenience in operation, safety and reliability.

The single raw material of the invention has the following functions and effects:

dried rehmannia root: cold in nature and sweet in taste. It enters heart, liver and kidney meridians. The efficacy is as follows: clear heat and cool blood, nourish yin and promote the production of body fluid. Can be used for treating heat entering nutrient-blood, epidemic febrile disease, macula, hematemesis, epistaxis, yin injury due to fever, crimson tongue, polydipsia, constipation due to body fluid consumption, fever due to yin deficiency, bone steaming, fatigue, internal heat, and diabetes.

Yam; mild in nature and sweet in taste. It enters spleen, lung and kidney meridians. The efficacy is as follows: tonify spleen and stomach, promote the production of body fluid and nourish lung, tonify kidney and astringe essence. Can be used for treating spleen deficiency, anorexia, chronic diarrhea, lung deficiency, cough, asthma, spermatorrhea, leukorrhagia, frequent micturition, and diabetes due to deficiency heat. The bran-parched rhizoma Dioscoreae has effects of invigorating spleen and invigorating stomach. It is also indicated for spleen deficiency, poor appetite, diarrhea, loose stool and leukorrhagia.

Dogwood fruit; slightly warm in nature, sour and astringent in taste. It enters liver and kidney meridians. The efficacy is as follows: tonify liver and kidney, astringe and induce depletion. Can be used for treating vertigo, tinnitus, soreness of waist and knees, sexual impotence, spermatorrhea, enuresis, frequent micturition, metrorrhagia, leukorrhagia, sweating, asthenia, internal heat, and diabetes.

Cinnamon: big and hot in nature, pungent and sweet in flavor. It enters kidney, spleen, heart and liver meridians. The efficacy is as follows: tonify fire and strengthen yang, induce fire to return to original, dispel cold to alleviate pain, and warm and dredge meridians. Can be used for treating sexual impotence, cold womb, cold pain of waist and knee, asthma due to kidney deficiency, floating of deficient yang, giddiness, conjunctival congestion, cold pain of heart and abdomen, vomiting and diarrhea due to deficiency cold, cold hernia, abdominal pain, dysmenorrhea, and amenorrhea.

Preparing monkshood: large heat in nature, pungent and sweet in flavor; is toxic. It enters heart, kidney and spleen meridians. The efficacy is as follows: reviving yang and rescuing from collapse, tonifying fire and supporting yang, dispelling cold and relieving pain. Can be used for treating yang exhaustion, collapse, cold limbs, slight pulse, deficiency of heart-yang, thoracic obstruction, cardialgia, asthenia cold, emesis, diarrhea, abdominal psychroalgia, kidney yang deficiency, sexual impotence, cold womb, yin cold edema, yang deficiency, exogenous pathogenic factor, and arthralgia due to cold-dampness.

Radix cyathulae: mild in nature, sweet and slightly bitter in taste. It enters liver and kidney meridians. The efficacy is as follows: dispel stasis, dredge meridians, dredge joints, induce diuresis and treat stranguria. Can be used for treating amenorrhea, abdominal mass, pain of placenta, traumatic injury, rheumatalgia, foot flaccidity, spasm of muscles, hematuria, and stranguria with blood.

Morinda officinalis: slightly warm in nature, sweet and pungent in flavor. It enters kidney and liver meridians. The efficacy is as follows: tonify kidney yang, strengthen tendons and bones, dispel wind-damp. Can be used for treating sexual impotence, spermatorrhea, infertility due to cold womb, menoxenia, cold pain of lower abdomen, rheumatic arthralgia, and flaccidity of tendons and bones.

Baked ginger: hot in nature and pungent in flavor. It enters spleen, stomach and kidney meridians. The efficacy is as follows: warm meridians to stop bleeding, warm middle energizer to alleviate pain. Can be used for treating yang deficiency, hemorrhage, hematemesis, metrorrhagia, metrostaxis, spleen and stomach deficiency cold, abdominal pain, vomiting and diarrhea.

Earthworm: cold in nature and salty in taste. It enters liver, spleen and bladder meridians. The efficacy is as follows: clear heat and calm fright, dredge meridians, relieve asthma and induce diuresis. Can be used for treating hyperpyrexia, unconsciousness, convulsive epilepsy, convulsion, arthralgia, numbness of limbs, hemiplegia, cough and asthma due to lung heat, edema, and oliguria.

Honey: mild in nature and sweet in taste. It enters lung, spleen and large intestine meridians. The efficacy is as follows: tonify middle energizer, moisten dryness, alleviate pain, remove toxicity; promoting tissue regeneration and healing wound for external use. Can be used for treating abdominal pain, dry cough due to lung dryness, constipation due to intestinal dryness, and toxic materials of radix Aconiti Kusnezoffii; it is indicated for sores and ulcers, scald due to hot water or fire.

Rice vinegar: warm in nature, sour and bitter in taste. Entering liver and stomach meridians; the efficacy is as follows: disperse blood stasis, stop bleeding, remove toxicity and kill parasites. Can be used for treating puerperal blood dizziness, jaundice, yellow sweat, hematemesis, epistaxis, hematochezia, carbuncle, cellulitis, sore, and swelling, and also can relieve fish and vegetable poisoning.

The invention adopts the principle of combining raw materials:

the traditional Chinese medicine composition adopted by the invention can be divided into the categories of edema, turbid urine and the like according to the characteristics of nephrotic syndrome, the basic pathogenesis of the traditional Chinese medicine composition is based on spleen-kidney deficiency, and the symptoms of spleen-kidney yang deficiency, blood stasis blocking collaterals and water-dampness retention are mainly caused by the onset of the disease, just as in the cloud of Jingyue quan Shu: "Water is the extreme yin, so it is in the kidney; water disturbs earth, so it is localized in the spleen. Spleen deficiency can prevent water from controlling soil; kidney deficiency can cause water deficiency leading to recklessly flow. Deficiency of spleen yang, dysfunction of transportation and transformation, and excessive dampness; insufficiency of kidney yang, failing to warm and nourish spleen-earth and water failing to dominate, aggravate the water-fluid distribution disorder. Blood stasis is a product of insufficient yang qi and a cause of pathological products, and can block qi movement and adversely affect the movement of yang qi. Therefore, the cinnamon with large pungent and large heat and the prepared aconite root are taken as monarch drugs to warm the kidney, strengthen the spleen and strengthen yang, and the kidney yang is the root of the yang qi of the whole body of the human body, so as to achieve the purpose of fundamentally warming; the raw rehmannia root, the dogwood, the yam, the medicinal cyathula root, the medicinal indianmulberry root and the earthworm are used as ministerial medicaments, wherein the raw rehmannia root, the dogwood and the yam play roles in tonifying kidney, nourishing yin, securing essence, tonifying qi and strengthening spleen, so-called 'seeking yang from yin', and the medicinal indianmulberry root, the earthworm and the medicinal cyathula root play roles in promoting blood circulation, removing blood stasis, dredging collaterals, warming kidney, inducing diuresis and relieving swelling; the processed ginger and the rice vinegar are used as adjuvant drugs, the processed ginger assists in preparing monkshood and cinnamon to strengthen yang, benefit spleen and warm kidney, and the rice vinegar assists in activating blood circulation and dissipating blood stasis of morinda officinalis, earthworm and medicinal cyathula root; the honey is used as a guiding drug to play a role in harmonizing the drugs and prevent the skin from being damaged by the pungent and hot property of the prepared aconite. The composition of the invention has the effects of warming kidney and strengthening spleen, promoting blood circulation and removing obstruction in channels, and inducing diuresis to alleviate edema.

The invention has the following acupuncture point selection:

the selection of the acupoints is mainly based on the point combination of Shu and alarm, Ben Jing and Point combination, the point selection of the exterior and interior meridians and the empirical points, among which Shenshu is the back Shu point of the kidney where the essence-qi of the zang-fu organs is infused and converged on the back of the human body, from which the cold-damp qi of the kidney is transported to the bladder meridian of the foot Taiyang and excreted out of the body through sweat, urine and feces. Jingmen is the alarm point of kidney, mainly indicated for the unfavorable channel of water, the essential point for tonifying kidney and inducing diuresis, and the gate of water flow in and out, in combination with Shenshu, has the wonderful actions of invigorating spleen, treating stranguria, warming yang and tonifying kidney. Re-flowing is the channel point of kidney meridian, Taixi is the original and transport point of kidney meridian, and the combination of them can tonify kidney, nourish yin, induce diuresis to alleviate edema, and tonify innate life. Pishu and Geshu are acupoints on bladder meridian of foot Taiyang of the exterior and interior of kidney, and Pishu is matched with Zusanli and Guanyuan to supplement qi and strengthen yang, thus reinforcing water, strengthening spleen and stomach and helping acquired days; geshu is called as blood vessel and can activate blood and dissipate blood stasis, unblock meridians. The water is located on the midline of the front part of the human body and at the points of the conception vessel, and has the effects of promoting diuresis, regulating qi and relieving pain.

Compared with the prior art, the invention has the following beneficial effects:

the traditional Chinese medicine composition provided by the invention adopts an external acupoint application form, is administered through skin, promotes medicine absorption by applying, realizes acupoint stimulation, achieves the effects of warming kidney and strengthening spleen, promoting blood circulation and removing obstruction in channels, and inducing diuresis to alleviate edema, further reduces proteinuria, improves hypoproteinemia, reduces edema, improves the immune function of a patient, and achieves a treatment effect. The medicine is safe, has no toxic or side effect, is simple and convenient to operate, has direct curative effect, low price and good patient compliance.

(IV) detailed description

The invention will be further described with reference to specific examples, but the scope of the invention is not limited thereto:

the medicinal materials used in the invention are collected and prepared according to the 2015 edition of Chinese pharmacopoeia.

Example 1 Chinese medicinal composition and method of use

1. Preparing an article: chinese medicinal ball, therapeutic bowl, patch, rice vinegar, and Mel

The traditional Chinese medicine composition comprises the following components in parts by weight: 15 parts of radix rehmanniae recen, 15 parts of Chinese yam, 10 parts of dogwood, 10 parts of cinnamon, 10 parts of prepared aconite root, 10 parts of medicinal cyathula root, 10 parts of earthworm, 10 parts of morinda officinalis and 5 parts of baked ginger.

2. Preparing the traditional Chinese medicines:

weighing 15g of radix rehmanniae recen, 15g of Chinese yam, 10g of dogwood, 10g of cinnamon, 10g of prepared monkshood, 10g of medicinal cyathula root, 10g of earthworm, 10g of medicinal indianmulberry root and 5g of baked ginger according to the formula amount, respectively grinding into powder (the diameter is 0.5mm-1.5mm), mixing, adding 30g of a mixture of rice vinegar and honey (the mass ratio of the rice vinegar to the honey is 1.5: 1), mixing into paste, uniformly applying force during paste mixing, and fully mixing the medicine powder with the honey and the rice vinegar. The paste is prepared by kneading into 0.6-1.0cm spherical shape.

3. Selecting acupuncture points:

shenshu (bilateral), Jingmen (bilateral), Guanyuan, Shu, Pishu (bilateral), Geshu (bilateral), Zusanli (bilateral), Fuliu (bilateral), Taixi (bilateral). Order the patient to take the sitting position or the supine position to expose the acupuncture points.

4. Acupoint application

A. The prepared traditional Chinese medicine ball is placed on a plaster of 2cm multiplied by 2cm and is sequentially pasted on Guanyuan, Shu, Shenshu, Jingmen, Pishu, Geshu, Zusanli, Fuliu and Taixi acupuncture points (all the acupuncture points are pasted).

B. The plaster is applied for 2 hours for the first time, and then each time is 4 hours, and the plaster is applied every 7 days for 8 times as a course of treatment. If itching, pain, swelling, etc. appear, it can be removed in advance to avoid blister and desquamation. Can be used for bathing after 6 hours.

C. It is not suitable for eating uncooked, cold, greasy, spicy food in the same day. Rest, wind-cold-proof and emotional activities.

D. After being applied, if skin vesicles appear on the local part, the skin vesicles can be absorbed by the patient without treatment. If the blister is large, the local protection is enhanced, the infection is avoided, the iodophor is used for disinfection, the liquid in the blister is removed, sterile gauze is covered, the drying is kept, and the bathing is forbidden within 6 hours after the application.

5. Case 1

Shen somewhere, man, 59 years old, "repeat foam urine with edema of both lower limbs for more than 10 years", the patient has no obvious inducement before more than 10 years and edema of both lower limbs with foam increase in urine, and the urine protein +++ "is looked for in local hospital. The clinic of a Hangzhou hospital, carrying out renal biopsy puncture, and showing the pathology: mesangial proliferative glomerulonephritis. After the patient is subjected to prednisone acetate and tacrolimus combined maintenance immunotherapy and symptomatic support therapy such as blood pressure reduction, blood sugar reduction, lipid regulation, kidney protection, stomach protection and the like, the long-term urinary protein fluctuates from + -to + +. The patients are weak in constitution, have symptoms of increased urinary foam, nocturia for 2-3 times, easy fatigue and weakness, soreness and pain of waist and back, abdominal fullness and distention, loose stool, no edema of lower limbs, pale and white tongue, thin and white fur with tooth marks and thready pulse.

And (4) acupoint application. It is administered once every 7 days for 8 weeks as a treatment course. Before use: 0.845g of 24-hour urinary protein and 31.0g/L of serum albumin; after use: 0.578g of 24-hour urine protein and 33.9g/L of serum albumin. The patients have the symptoms of improvement of hypoproteinemia, obvious reduction of urine foam, nocturia for 1 time, improvement of lumbago and basic shaping of excrement. The patients have stable kidney disease after half a year of follow-up.

Example 2

The formula of the traditional Chinese medicine in the embodiment 1 is changed into the following formula: 20g of radix rehmanniae recen, 15g of yam, 12g of dogwood, 12g of cinnamon, 15g of prepared aconite root, 15g of medicinal cyathula root, 12g of earthworm, 12g of morinda officinalis and 9g of baked ginger.

The acupoint application and method of use of example 1 was used.

Case 2, yao a certain, woman, 57 years old, "edema of both lower limbs occurred repeatedly for 17 years", edema of both lower limbs appeared after the patient had tired 17 years ago, hospitalization in a certain third hospital in hangzhou city, urine protein ++++, kidney biopsy puncture show: glomeruli were slightly diseased. Is used for glucocorticoid therapy, diuresis for promoting detumescence, ARB for controlling albuminuria, BAILING Capsule, nephritis for protecting kidney, and edema relieving. After discharge, the patient has urine protein fluctuation from + + to + + +, and is treated with prednisone and cyclosporine, urine protein is not reduced, and edema of lower limbs occurs repeatedly. When the physician visits the clinic, the physician is marked by edema of the lower limbs, depression of the lower limbs, and even lower back, abdominal distention, loose stool, lusterless complexion, poor spirit, poor appetite, poor sleep, pale tongue, white and greasy coating, and deep and slow pulse.

The patient uses the preparation of the invention for 1 course of treatment on the basis of the original western medicine treatment scheme. Before use: 3.6g of 24-hour urine protein and 19.3g/L of serum albumin; after use: 2.4g of 24-hour urine protein and 21.9g/L of serum albumin. After patients complain of the invention, the waist has warm feeling, the spirit is improved, the stool is basically formed, the edema of the lower limbs is relieved, the stomach is accommodated, and the urine protein is reduced.

Example 3

The formula of the traditional Chinese medicine in the embodiment 1 is changed into the following formula: 12g of radix rehmanniae recen, 12g of yam, 9g of dogwood, 6g of cinnamon, 5g of prepared aconite root, 9g of medicinal cyathula root, 9g of earthworm, 9g of morinda officinalis and 3g of baked ginger.

The acupoint application and method of use of example 1 was used.

Case 3, Zhai some, male, age 32, and "edema of both lower limbs for half a year, aggravated for 1 week". The patient had edema of both lower limbs after tiredness for half a year, accompanied by soreness and weakness of the waist and sensation of coldness, and slightly relieved after rest, which was not considered at that time. Before 1 week, the patient becomes more edematous after staying up, the depression is obvious and not easy to recover, and the foam in the urine is increased, the fatigue is obvious and no dizziness exists. Local hospital admission: qualitative urine protein +++, 20g/L plasma albumin, renal biopsy aspiration, pathological indication: stage three of membranous nephropathy. After the treatment of the cyclosporine and the prednisone tablet, the nephropathy of a patient is partially relieved, the 24-hour urine protein is 3.6g, the plasma albumin is 38.1g/L, the proteinuria is repeated, the stool is normal, the tongue is pale, the fur is thin, and the pulse is deep and fine.

Based on the original treatment, the preparation of the invention is used for 1 course of treatment. And (4) rechecking after use: 3.2g of urine protein and 41.3g/L of plasma albumin in 24 hours. The patients feel the symptoms of waist soreness and hypodynamia improved, urine protein is reduced, and plasma albumin is recovered to be normal.

Example 4

The formula, the acupoint application and the use method of example 1 were adopted.

Case 4, wu somebody, woman, age 74, "repeat urine foam for more than 1 year", patient had no obvious inducement to urine foam and mild edema of lower limbs more than 1 year ago, and the first hospital affiliated to zhejiang university was called for kidney activity: the antibody quantification of the serum PLA2R is 65.638IU/mL, tacrolimus is taken orally for 4 months at 1mg earlier and 0.5mg later, tripterygium wilfordii is taken orally for 1 month after 100mg bid, and the membranous nephropathy is not relieved. The patient feels cramp and palpitation and discomfort when feeling the lower limbs. The blood test is conventional, the liver and kidney function is normal, the electrocardiogram is very different, the quantity of urine protein is 4.46g in 24 hours, and the quantity of plasma albumin is 29.1 g/L.

The treatment is continued with an immunosuppressive regimen using the formulation of the invention for 1 course. And (4) rechecking after use: the amount of urinary protein was 3.4g and plasma albumin 25.8g/L at 24 hours. Lower limb cramps, palpitation, discomfort and reduced urinary foam.

Example 5

The acupoint application and method of use of example 1 was used.

In case 5, Wangzhi, male, age 55, the patient had edema of both lower limbs with increased urinary foam for more than 3 months before the cold, but did not pay attention to the edema of both lower limbs with increased urinary foam after the cold for more than 3 months. After 2 months, patients have eyelid swelling, and are diagnosed in local hospitals in Hubei province, and the disease condition is controlled by looking for urine protein + + +, serum creatinine 97.1umol/L and albumin 19.2g/L, taking Jinshuibao and furosemide. The patient had a reduced conscious edema. To clarify the cause of the disease, the patients were examined live in renal puncture in a hospital in Ningbo city: stage II membranous nephropathy. Immunofluorescence: PLA2R (+/-), IgG + + + diffuse, globular, presenting fine granular silence along the capillary loops. After the treatment of methylprednisolone tablets and tacrolimus, the edema of the lower limbs of the patient is resolved, the urine protein is still + + +, the tongue is pale red, the fur is white and greasy, and the pulse is wiry.

The patient requires 2 courses of treatment with the formulation of the invention, before use: the amount of urinary protein was 4.8g and plasma albumin was 19.2g/L at 24 hours. After use: the amount of urinary protein was 4.1g at 24 hours, and the amount of plasma albumin was 24.9 g/L. After the composition is used, patients have improved conscious spirit, increased physical strength, reduced urine protein and increased plasma albumin.

Example 6

The acupoint application and method of use of example 1 was used.

In case 6, a certain Chinese pulsatilla root, a woman in the age of 56 years, edema of both lower limbs with foam urine for more than 7 years, urine protein + + +, slight edema of the whole body with a small amount of foam urine when the patient is examined 7 years ago, and the previous history of hepatitis B. The physician needs to diagnose the pathological symptoms of kidney biopsy in a third hospital in Hangzhou city: atypical membranous nephropathy. When the nephrotic syndrome caused by hepatitis B is considered, entecavir is used for resisting virus, and the double-Bott is used for reducing blood pressure by combining the surrogate writing, the Lipitor is used for reducing blood pressure and the traditional Chinese medicine is used for treating, so that the condition is improved. In 2019, 1 and 29 days, the patient is diagnosed with fever and cough in the hospital in Songyang county, the patient is diagnosed with lung infection, and is given antibiotic anti-infection and oseltamivir antiviral, and the patient has severe edema of lower limbs, and then the patient is transferred to the hospital, and the fever and cough are improved after anti-infection treatment. And (3) detecting urine protein + + +, continuously not relieving, carrying out immunosuppression on the patient by combining 40mg of methylprednisolone and 1mg q12h of tacrolimus, increasing the blood concentration in diltiazem, improving the lower limb edema of the patient, reducing the urine protein, and maintaining the concentration to be + to + +. The patients are weak in constitution, easy to catch cold, pale tongue with white fur, thin and white fur and thready pulse.

After the preparation of the invention is used for 1 course of treatment, the quantity of the urine protein is 0.726g in 24 hours, and the quantity of the plasma albumin is 41.9 g/L. After use: the amount of urine protein was 0.398g and plasma albumin was 42.2g/L at 24 hours. The patients with follow-up visit are half a year, the nephropathy is stable, the urine protein is reduced, and no cold appears.

Example 7

In case 7, a certain Chinese herb, named Henan Yi and woman, aged 65, shows that the protein in urine is more than 7 years old, and the patient in 7 years shows that the protein in urine is positive, the patient is hospitalized in a local hospital, the pathological condition of renal biopsy suggests membranous nephropathy, the patient is regularly treated with prednisone and cyclosporine for immunosuppression, the patient before 3 years is treated with protein in urine turned to negative, and then the patient is treated with Bailing capsule, Maixuekang and the like, so that the disease condition can be controlled. The patient has no obvious discomfort symptom, and has the symptoms of stomach reception, sleep peace, pale red tongue with thin coating and deep and thready pulse.

The preparation of the invention is used for 1 course of treatment, before use: the amount of urinary protein was 0.23g and plasma albumin was 36.8g/L at 24 hours. After use: the amount of urine protein was 0.16g and plasma albumin was 44.0g/L at 24 hours. The plasma albumin of the patient is obviously improved.

Example 8

The acupoint application and method of use of example 1 was used.

In case 8, Chua is somebody, male and 64 years old, "urine test is abnormal for 1 year after physical examination", kidney puncture biopsy shows second-stage membranous nephropathy, and after treatment with immunosuppressive regimen, proteinuria is repeated, sunken edema of both lower limbs, dark red tongue with thin and white fur, and deep and thready pulse.

2 months after using the formulation of the invention, before use: 7.1g of 24-hour urine protein and 18.3g/L of serum albumin; after use: 5.0g of 24-hour urine protein and 19.0g/L of serum albumin. After the medicine is used, the lower limb edema of a patient is relieved, the symptoms of waist soreness and weakness are improved, and the nocturia frequency is reduced from 5 times to 2 times per night.

Example 9

Case 9, old somebody, woman, age 58, "repeat urine foam increase for more than 2 years". The patients found that the urine foam is increased and the urine volume is basically normal 2 years ago, and the patients occasionally suffer edema of the lower limbs after fatigue. Nephrotic syndrome is considered in the local hospital for diagnosis, renal biopsy indicates membranous nephropathy, and the patient takes cyclosporin 75mg bid for more than 9 months, so that the nephropathy is partially relieved, the patient feels self-complaint and is afraid of cold, loose stool is thin, the patient feels pale with tongue, thin fur and thready pulse are 4-5 times a day.

The original western medicine treatment scheme is temporarily unchanged, and the preparation of the invention is used for 1 course of treatment. Before use: 3.2g of 24-hour urine protein and 37.3g/L of serum albumin; after use: 2.7g of 24-hour urine protein and 37.7g/L of serum albumin. After the medicine is used, the symptoms of cold intolerance and loose stool of patients are improved, and the urine protein is reduced. The patients have stable disease condition after half a year of follow-up visit.

Example 10

In case 10, old woman and 59 years old, the patient had no obvious induction of soreness and weakness of waist and urine with increased urine foam for more than 19 years before 19 years, and the patient had an increased urine foam with soreness and weakness of waist and urine, and had a certain three hospitals in Hangzhou, urine protein + + +, and renal biopsy after the disease indicated membranous nephropathy. Then, through the treatment of Chinese and western medicines, the urine protein is maintained between + and +++, and the kidney function is normal. Patients still feel uncomfortable, soreness and weakness of waist, poor sleep, poor spirit, obvious edema of lower limbs after fatigue, slight relief after rest, pale red tongue with greasy coating and thready pulse.

The patient uses the preparation of the invention for 1 course of treatment, before using: 0.648g of 24-hour urine protein and 18.9g/L of serum albumin; after use: 0.712g of 24-hour urine protein and 22.0g/L of serum albumin. After the application, the patient has reduced soreness and weakness, improved spirit and good sleep.

Example 11

Case 11, a certain queen, a woman, 58 years old, "recurrent urine foam increase with edema of both lower limbs for more than 1 year", patient had no obvious inducement for the occurrence of lower limb urine foam increase with edema of both lower limbs before 1 year, normal urine volume, occasional feelings of debilitation, soreness and weakness of waist and knees, no frequent and urgent urination, no macroscopic hematuria, renal biopsy was shown to the affiliated shaoyifu hospital of Zhejiang university: the atypical membranous nephropathy is treated by mellea and cyclosporine immunosuppression, ambowei antihypertensive, urine protein reduction, insulin hypoglycemic and other symptomatic support treatments, and the symptoms of the patient are improved before. But the lower limbs are slightly edematous, accompanied by foamy urine, poor sleep and nocturia for 2-3 times per day, and the weight is reduced by about 10Kg in the last year.

The preparation of the invention is used for 1 course of treatment on the basis of the original treatment, and before the use: 5.8g of 24-hour urine protein and 22.1g/L of serum albumin; after use: 3.1g of 24-hour urine protein and 25.6g/L of serum albumin. After the composition is used, urine protein of a patient is reduced, the body weight is basically stable, and hypodynamia and hypoproteinemia are improved. The lower limb edema did not recur after half a year of follow-up.

Claims

1. A traditional Chinese medicine composition for treating nephrotic syndrome is characterized by being prepared from the following raw materials in parts by weight: 12-20 parts of radix rehmanniae recen, 12-15 parts of yam, 9-12 parts of dogwood, 6-12 parts of cinnamon, 5-15 parts of prepared monkshood, 9-15 parts of medicinal cyathula root, 9-12 parts of earthworm, 9-12 parts of morinda officinalis and 3-9 parts of baked ginger.

2. The traditional Chinese medicine composition of claim 1, wherein the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15 parts of radix rehmanniae recen, 15 parts of Chinese yam, 10 parts of dogwood, 10 parts of cinnamon, 10 parts of prepared aconite root, 10 parts of medicinal cyathula root, 10 parts of earthworm, 10 parts of morinda officinalis and 5 parts of baked ginger.

3. The traditional Chinese medicine composition of claim 1, wherein the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20 parts of radix rehmanniae recen, 15 parts of Chinese yam, 12 parts of dogwood, 12 parts of cinnamon, 15 parts of prepared aconite root, 15 parts of medicinal cyathula root, 12 parts of earthworm, 12 parts of morinda officinalis and 9 parts of baked ginger.

4. The traditional Chinese medicine composition of claim 1, wherein the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 12 parts of radix rehmanniae recen, 12 parts of yam, 9 parts of dogwood, 6 parts of cinnamon, 5 parts of prepared aconite root, 9 parts of medicinal cyathula root, 9 parts of earthworm, 9 parts of morinda officinalis and 3 parts of baked ginger.

5. A patch prepared from the Chinese medicinal composition of claim 1.

6. A patch according to claim 5, wherein said patch is prepared by the following method: grinding the raw materials of the traditional Chinese medicine composition into powder according to the formula amount, mixing, adding rice vinegar and honey, blending into paste, and rubbing into a spherical shape to obtain a traditional Chinese medicine bolus; placing the Chinese medicinal ball on the patch, and making into patch.

7. A patch according to claim 6, wherein the ratio of rice vinegar to honey is 1.5: 1, the total adding amount of the rice vinegar and the honey is 1/4-1/3 of the total mass of the medicine.

8. The use of the composition of claim 1 in the preparation of a medicament for the treatment of nephrotic syndrome.