CN101862376B - Medicament for treating oviduct obstructive infertility and preparation method thereof - Google Patents
Medicament for treating oviduct obstructive infertility and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicament for treating oviduct obstructive infertility and a preparation method thereof. In the medicament, suberect spatholobus stem, ovientvine, sargentgloryvine stem, Chinese starjasmine stem, Japanese honeysuckle stem, caulis polygoni multiflori, marsdenia tenacissima, millettia reticulata benth., common fibraurea stem and astragalus are taken as raw materials, and according to different properties of the medicaments, the medicaments are pulverized, concentrated, extracted, dried, repulverized and blended in proportion and mixed with a pharmaceutically-acceptable carrier or a pharmaceutically-acceptable excipient to prepare various formulations. The medicament for treating the oviduct obstructive infertility has the advantages of unique formula and preparation method, obvious treatment effect and no toxic or side effect.
Description
(1) technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of oviduct obstructive sterility, particularly relating to a kind of is the treatment oviduct obstructive sterility medicine that raw material is made with Chinese medicine, and the preparation method of this medicine.
(2) background technology
Female acyesis belongs to common clinical, and its sickness rate accounts for the women of child-bearing age's 10%, and the trend that increases is year by year arranged.Oviduct obstructive sterility accounts for 1/3 of infertility.The pathological changes reason is based on inflammation, but non-inflammatory disorders (as endometriosis) rate is also very important in gradually increase.China's medical circle traditional treatment salpingemphraxis adopts methods such as antibiotic medicine, coaxial pipe mediation art more.Because of salpingemphraxis mostly is caused by chronic salpingitis, the reason that antibiotic therapy is unsatisfactory, the one, antibiotic has produced drug resistance, and the 2nd, antibiotic diseased region more difficult to get access; Coaxial pipe mediation art and fallopian tube feel intubate mediation art (Luo Lilan. infertile and sterile. second edition. the People's Health Publisher, 2009:208), just higher to the logical again success rate of fallopian tube proximal occlusion, effect to the far-end salpingemphraxis is unsatisfactory, and easily causes fallopian tube perforation, stomachache, complication such as hemorrhage; Salpingemphraxis operation reopening operation, though certain curative effect is arranged, wound is big, success rate is low; Treatment by Chinese herbs still has the integrally-regulated superiority of whole body except that local therapeutic effects, but heat-clearing and detoxifying herb treatment is adopted in treatment by Chinese herbs more, and fever, detoxicating and treating is unsatisfactory, because the Chinese medical discrimination majority is not due to the pyretic toxicity; Even adopt the blood-activating and stasis-removing treatment, also be general blood-activating stasis-removing kind Chinese medicine, the effect of its dredging oviduct lags far behind liana kind Chinese herbs.Other trouble of boiling medicine, the constant deficiency of taking medicine.Though the medicine of many treatment oviduct obstructive sterilityes is arranged at present, obtained some curative effects, but cure rate is still undesirable.So people are still seeking a kind ofly to treat the oviduct obstructive sterility better effects if, and do not have toxic and side effects, the Chinese medicine of being convenient to take.
(3) summary of the invention
Technical problem to be solved by this invention provides a kind of medicine for the treatment of oviduct obstructive sterility, and this medicine can effectively improve the actual cure rate of oviduct obstructive sterility, is convenient to orally, and has no side effect.
Another technical problem to be solved by this invention provides the preparation method of this medicine.
Technical problem to be solved by this invention is to realize by the following technical solutions:
The inventor thinks that through clinical practice for many years and experimentation mostly the basic pathogenesis of oviduct obstructive sterility is the stagnation of blood stasis venation, again according to Ming Dynasty's " book on Chinese herbal medicine converges and says " institute's cloud: " genus of all tendrils; all can stimulate the menstrual flow " into network, fallopian tube is just like a rattan, theory according to traditional Chinese medical science classification according to manifestation, and in conjunction with the clinical practice experience of using liana kind Chinese herbs for many years, find that liana kind Chinese herbs truly has promoting blood circulation to restore menstrual flow preferably, the merit of dredging oviduct, so founded treatment rule based on blood circulation promoting and blood stasis dispelling, under the guidance of this treatment rule with liana kind Chinese herbs prescription in addition.Medicine of the present invention is made (consumption is a weight portion) by following raw materials according:
0.5～1.5 part of 0.5～1.5 portion of Caulis Sargentodoxae of 0.5～1.5 part of Caulis Sinomenii of Caulis Spatholobi
0.5～1.5 part of 0.5～3 part of Caulis Polygoni Multiflori of 0.5～1.5 part of Caulis Lonicerae of Caulis Trachelospermi
0.5～6 part of 0.5～3 portion of Caulis Fibraureae of 0.5～3 part of Yunnan Caulis Spatholobi of Caulis Marsdeniae Tenacissimae
0.5～3 part of the Radix Astragali
We use Caulis Spatholobi, Yunnan Caulis Spatholobi blood circulation promoting and enriching, dredging the meridian; Caulis Sargentodoxae is invigorated blood circulation, heat-clearing and toxic substances removing; Caulis Sinomenii, Caulis Trachelospermi, Caulis Lonicerae the meridian dredging, but Caulis Lonicerae and heat-clearing and toxic substances removing; Phlegm-damp is pressed from both sides in prolonged illness more, eliminates the phlegm with Caulis Marsdeniae Tenacissimae, and heat-clearing and toxic substances removing; The Caulis Fibraureae heat-clearing and toxic substances removing, the pathogenic fire purging relieving constipation; The Caulis Polygoni Multiflori nourishing blood to tranquillize the mind, collateral dredging; Radix Astragali tonifying Qi and lifting yang, inducing diuresis to remove edema promotes the production of body fluid and nourishes blood, the stagnant blood stasis dispelling of row, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation.Rattan class medicine quality coordination of potent and mild therapies, both the cloudy gas on ground nourishes, YANG in universe gas profit is moistened again, be able to stoop or to stand, kind meridians and collaterals dredging, so it is long-pending kind to remove the venation stasis of blood, venation is led to, blood stasis goes, and plays blood circulation promoting and blood stasis dispelling altogether, the give birth merit of unicorn of siphunculus.
The preferred weight proportioning of preparation medicine of the present invention is:
1.5 parts of 1.5 portions of Caulis Sargentodoxae of 1.5 parts of Caulis Sinomeniis of Caulis Spatholobi
1.5 parts of 3 parts of Caulis Polygoni Multiflori of 1.5 parts of Caulis Loniceraes of Caulis Trachelospermi
6 parts of 3 portions of Caulis Fibraureaes of 3 parts of Yunnan Caulis Spatholobis of Caulis Marsdeniae Tenacissimae
3 parts of the Radixs Astragali
The optimum weight proportioning of medicine of the present invention is:
1.5 parts of 1 portion of Caulis Sargentodoxae of 1.5 parts of Caulis Sinomeniis of Caulis Spatholobi
1 part of 1 part of Caulis Polygoni Multiflori of 1 part of Caulis Lonicerae of Caulis Trachelospermi
1 part of 3 portions of Caulis Fibraureae of 1 part of Yunnan Caulis Spatholobi of Caulis Marsdeniae Tenacissimae
1.5 parts of the Radixs Astragali
The source of the Chinese crude drug that above-mentioned best preferred embodiment is mentioned is as follows:
Caulis Sargentodoxae: be the dry rattan of Lardizabalaceae plant Caulis Sargentodoxae.Heat-clearing and toxic substances removing is arranged, invigorate blood circulation, the effect of wind-expelling pain-stopping.
Caulis Spatholobi: be the dry rattan of leguminous plant spatholobus suberectus.Blood circulation promoting and enriching is arranged, menstruction regulating and pain relieving, the effect of relaxing muscles and tendons and activating QI and blood in the collateral.
Yunnan Caulis Spatholobi: for Namas in the Magnoliacea plant distinguish the flavor of the son dry rattan.Blood circulation promoting and enriching is arranged, menstruction regulating and pain relieving, the effect of channels sootheing and network vessel quickening.
Caulis Fibraureae: be the dry rattan of menispermaceous plants Caulis Fibraureae.Heat-clearing and toxic substances removing is arranged, the effect of pathogenic fire purging relieving constipation.
Caulis Marsdeniae Tenacissimae: be the dry rattan of asclepiadaceae plant Caulis Marsdeniae Tenacissimae.Relieving cough and asthma is arranged, eliminate the phlegm, lactogenesis, the effect of heat-clearing and toxic substances removing.
Caulis Polygoni Multiflori: be the dry rattan of polygonum multiflorum thunb.Nourishing blood to tranquillize the mind is arranged, the effect of dispelling wind and removing obstruction in the collateral.
Caulis Sinomenii: be the dry rattan of menispermaceous plants Sinomenium acutum and hair Sinomenium acutum.Wind-damp dispelling is arranged, the meridian dredging, the effect of diuresis.
Caulis Trachelospermi: be the dry zone leaf rattan of apocynaceae plant trachelospermum jasminoide.Dispelling wind and removing obstruction in the collateral is arranged, removing heat from blood repercussive effect.
Caulis Lonicerae: be the caprifoliaceae plant dry stem branch of Radix Ophiopogonis.Heat-clearing and toxic substances removing is arranged, the effect of dispelling wind collateral dredging.
The Radix Astragali: be the dry root of leguminous plant Radix Astagali or Radix Astragali.Tonifying Qi and lifting yang is arranged, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema promotes the production of body fluid and nourishes blood, the stagnant blood stasis dispelling of row, expelling pus and toxin by strengthening QI, the effect of expelling pus and promoting granulation.
The title of the used medicine of the present invention, effect all are recorded in the Pharmacopoeia of the People's Republic of China: version in 2010. and one one.
The preparation technology of medicine of the present invention: above-mentioned raw materials directly can be pulverized or through the refining active component that obtains treating the oviduct obstructive sterility medicine of the extraction of the conventional extractive technique in this area such as decoction and alcohol sedimentation technique or ethanol extract from water precipitation as the present invention.Described active component can be made various pharmaceutical formulations such as powder, pill, tablet, oral liquid, granule, capsule etc. with pharmaceutically acceptable carrier or excipient composition.Wherein said pharmaceutically acceptable carrier or excipient are selected according to different dosage forms, and these used carriers or excipient can determine for the those of ordinary skill of pharmaceutical field.
Medicine of the present invention can prepare according to following three kinds of methods:
First method comprises the following steps: to take by weighing raw materials of traditional Chinese medicinal materials according to above-mentioned consumption; Above-mentioned Chinese crude drug is dried and crushed into fine powder as active component; Then above-mentioned active component is made various dosage forms with pharmaceutically acceptable excipient.
Second method comprises the following steps: to take by weighing raw materials of traditional Chinese medicinal materials according to above-mentioned consumption; Caulis Spatholobi, Yunnan Caulis Spatholobi are decocted with water 3 times, each 1.5 hours, filter, merging filtrate, evaporation and concentration is being dried and crushed into fine powder to the thick paste shape with Caulis Sinomenii, Caulis Sargentodoxae, Caulis Trachelospermi, Caulis Lonicerae, Caulis Polygoni Multiflori, Caulis Marsdeniae Tenacissimae, Caulis Fibraureae, the Radix Astragali, with above-mentioned thick paste mixing, drying is ground into fine powder; As active component; Above-mentioned active component is made various dosage forms with excipient pharmaceutically.
The third method comprises the following steps: to take by weighing Chinese crude drug according to above-mentioned consumption; Decoct with water three times, each 1～2 hour, filter, merging filtrate, evaporation and concentration is to the thick paste shape, makes various dosage forms as active component and pharmaceutically acceptable carrier or excipient.
Beneficial effect of the present invention:
The medical usage of pharmaceutical composition of the present invention: be used for oviduct obstructive sterility; Pharmacological effect: blood circulation promoting and blood stasis dispelling, the siphunculus unicorn of giving birth; Effective dose: medicine of the present invention is with dosage form every day of first method preparation 3 times, each 6～9 grams; Dosage form every day of second method preparation 3 times, each 5 grams; Dosage form every day of the third method preparation 3 times, each 1.2 grams; Using method: warm water is taken after mixing it with water.
Through the more than ten years clinical trial certificate, the preparation of pharmaceutical composition of the present invention is fairly obvious to the oviduct obstructive sterility curative effect, and does not see toxic and side effects, sees following test for details.
The test example: thing of the present invention is to the clinical efficacy of treatment oviduct obstructive sterility
1 clinical data
(1) this disease Western medicine diagnose standard and the Chinese medical discrimination standard [1] (genus syndrome of blood stasis) developed and published by Ministry of Health of the People's Republic of China of diagnostic criteria.
Western medicine diagnose standard: the diagnostic criteria that salpingitis is barrenness caused
1. hysterosalpingography confirm that obstruction of fallopian tube is smooth, obstruction or hydrops etc.;
2. do hydrotubation under the laparoscopy, confirm that obstruction of fallopian tube is smooth or obstructed, and adhesion in the pelvic cavity;
3. logical liquid or ventilate 2 times all obstructed.
More than have 1 to be consistent and can to diagnose in 3.
Chinese medical discrimination: syndrome of blood stasis
1. wedding is infertile for a long time;
2. how many delayed menstrual cyclees differs through amount, and the color purple has piece;
3. lack abdomen pain apart from pressing, face through more so;
4. tongue is dim a petechia;
5. stringy pulse or puckery.
Below 1. item adds all the other in every 3, and is promptly diagnosable.
(2) this disease of developing and publishing by Ministry of Health of the People's Republic of China of test case standard is included the case standard in and is got rid of the case standard
[1]
Include the case standard in:
1. meet infertility diagnosis and Chinese medical discrimination person.
2. former, secondary sterility all need (to contain 2 years) more than 2 years contraception person not.
3. Mr. and Mrs should live together, and separation person should have the above time of half a year to live together every year, and sexual life is normal.
4. bridegroom's or husband's side reproductive function is normal.
Get rid of case standard (comprising inadaptation or rejecting standard):
1. infertile due to congenital physiological defect or the deformity.
2. infertile due to the inherited genetic factors.
3. confirm person due to endometriosis, adenomyosis, hysteromyoma, the uterine hypoplasia on inspection.
4. bridegroom's or husband's side reproductive function is unusual.
5. the age is person below 22 years old or more than 45 years old.
6. be associated with the serious primary disease of cardiovascular, liver, kidney and hemopoietic system, the psychotic.
7. to research drug allergy person.
8. do not meet the standard of including in, not medication in accordance with regulations can't be judged that curative effect or data are not congruent to affect the treatment or safety judgement person.
(3) observation index is observed by this disease safety observation and health giving quality that Ministry of Health of the People's Republic of China develops and publishes
[1]Requirement is done.
Safety observation:
1. general health check-up project.
2. blood, urine, just routine test.
3. the heart, liver, kidney function test.
Health giving quality observation:
1. pregnant situation and card Hou Bianhua.
2. the unobstructed inspection of fallopian tube: preferably make lipiodol angiography or acoustic contrast, logical liquid, ventilation also check can, but every inspection should be got rid of the false obstruction that fallopian tubal spasm causes.
3. laparoscopy is led to the liquid test to understand the pelvic cavity situation and to do under peritoneoscope.
(4) physical data totally 120 routine oviduct obstructive sterility reception tests, minimum 24 years old of age, maximum 39 years old, average 29 years old; The marriage time is the shortest 2 years, and is the longest 18 years, all patients' diagnosis all in the recent period through hysterosalpingography confirm that obstruction of fallopian tube is smooth, obstruction or hydrops.The clinical symptoms that enters this research patient all has infertile more than 2 years after marriage; How many delayed menstrual cyclees differs through amount, and the color purple has piece; Few abdomen pain is apart from pressing, and faces through more so; Tongue is dim petechia; Stringy pulse or symptom such as puckery are syndrome of blood stasis.
2 Therapeutic Method
Give the embodiment of the invention 1 prepared pill during treatment, each 9g, every day 3 times.Not drug withdrawal in menstrual period.3 months was 1 course of treatment, generally serve on 3 courses of treatment.
3 therapeutic outcomes
(1) this disease curative effect determinate standard of developing and publishing by Ministry of Health of the People's Republic of China of criterion of therapeutical effect
[1]Judge curative effect.
Recovery from illness: treat back 2 years with interior pregnant person.
Invalid: 2 years not pregnant persons after treating continuously.
(2) therapeutic effect 90 examples of fully recovering, invalid 30 examples.Be not judged to be in the 30 invalid examples through unobstructed person's 15 examples of hysterosalpingography confirmation fallopian tube though wherein become pregnant.
This side of clinical observation has better curative effect to the blood stasis oviduct obstructive sterility, and does not see toxic and side effects.
List of references
1. Ministry of Health of the People's Republic of China. new Chinese medicine clinical research guideline. (first collection). Beijing: 1993; 276～280
(4) specific embodiment
Further describe the present invention by the following examples.
Embodiment 1: the preparation of pill
Take by weighing these raw materials of traditional Chinese medicinal materials according to following consumption:
1.5 parts of 1.5 portions of Caulis Sargentodoxae of 1.5 parts of Caulis Sinomeniis of Caulis Spatholobi
1.5 parts of 3 parts of Caulis Polygoni Multiflori of 1.5 parts of Caulis Loniceraes of Caulis Trachelospermi
6 parts of 3 portions of Caulis Fibraureaes of 3 parts of Yunnan Caulis Spatholobis of Caulis Marsdeniae Tenacissimae
3 parts of the Radixs Astragali
Caulis Spatholobi, Yunnan Caulis Spatholobi are decocted with water 3 times, each 1.5 hours, filter merging filtrate, evaporation and concentration is to the thick paste shape, Caulis Sinomenii, Caulis Sargentodoxae, Caulis Trachelospermi, Caulis Lonicerae, Caulis Polygoni Multiflori, Caulis Marsdeniae Tenacissimae, Caulis Fibraureae, the Radix Astragali are being dried and crushed into fine powder, with above-mentioned thick paste mixing, drying, be ground into fine powder, with above-mentioned thick paste mixing, drying is ground into fine powder; Mixing, the general micropill of making of water, drying is made.
Implementation column 2: the preparation of pill
Take by weighing these raw materials of traditional Chinese medicinal materials according to following consumption:
1.5 parts of 1.5 portions of Caulis Sargentodoxae of 1.5 parts of Caulis Sinomeniis of Caulis Spatholobi
1.5 parts of 3 parts of Caulis Polygoni Multiflori of 1.5 parts of Caulis Loniceraes of Caulis Trachelospermi
6 parts of 3 portions of Caulis Fibraureaes of 3 parts of Yunnan Caulis Spatholobis of Caulis Marsdeniae Tenacissimae
3 parts of the Radixs Astragali
With above-mentioned Chinese crude drug; Decoct with water three times, each 1～2 hour, filter, merging filtrate, evaporation and concentration is to the thick paste shape, and drying is ground into fine powder; Mixing, the general micropill of making of water, drying is made.
Implementation column 3: the preparation of pill
Take by weighing these raw materials of traditional Chinese medicinal materials according to following consumption:
1.5 parts of 1.5 portions of Caulis Sargentodoxae of 1.5 parts of Caulis Sinomeniis of Caulis Spatholobi
1.5 parts of 3 parts of Caulis Polygoni Multiflori of 1.5 parts of Caulis Loniceraes of Caulis Trachelospermi
6 parts of 3 portions of Caulis Fibraureaes of 3 parts of Yunnan Caulis Spatholobis of Caulis Marsdeniae Tenacissimae
3 parts of the Radixs Astragali
Above-mentioned Chinese crude drug is dried and crushed into fine powder.Mixing, the general micropill of making of water, drying is made.
Embodiment 4: the preparation of tablet
Take by weighing these raw materials of traditional Chinese medicinal materials according to following consumption:
1.5 parts of 1 portion of Caulis Sargentodoxae of 1.5 parts of Caulis Sinomeniis of Caulis Spatholobi
1 part of 1 part of Caulis Polygoni Multiflori of 1 part of Caulis Lonicerae of Caulis Trachelospermi
1 part of 3 portions of Caulis Fibraureae of 1 part of Yunnan Caulis Spatholobi of Caulis Marsdeniae Tenacissimae
1.5 parts of the Radixs Astragali
Caulis Spatholobi, Yunnan Caulis Spatholobi are decocted with water 3 times, each 1.5 hours, filter, merging filtrate, evaporation and concentration is being dried and crushed into fine powder to the thick paste shape with Caulis Sinomenii, Caulis Sargentodoxae, Caulis Trachelospermi, Caulis Lonicerae, Caulis Polygoni Multiflori, Caulis Marsdeniae Tenacissimae, Caulis Fibraureae, the Radix Astragali, with above-mentioned thick paste mixing, drying is ground into fine powder; Add an amount of adjuvant, mixing is granulated, and compacting is made in flakes.
Embodiment 5: the preparation of tablet
Take by weighing these raw materials of traditional Chinese medicinal materials according to following consumption:
1.5 parts of 1 portion of Caulis Sargentodoxae of 1.5 parts of Caulis Sinomeniis of Caulis Spatholobi
1 part of 1 part of Caulis Polygoni Multiflori of 1 part of Caulis Lonicerae of Caulis Trachelospermi
1 part of 3 portions of Caulis Fibraureae of 1 part of Yunnan Caulis Spatholobi of Caulis Marsdeniae Tenacissimae
1.5 parts of the Radixs Astragali
With above-mentioned Chinese crude drug; Decoct with water three times, each 1～2 hour, filter, merging filtrate, evaporation and concentration is to the thick paste shape, and drying is ground into fine powder; Mixing adds an amount of adjuvant, and mixing is granulated, and compacting is made in flakes.
Embodiment 6: the preparation of tablet
Take by weighing these raw materials of traditional Chinese medicinal materials according to following consumption:
1.5 parts of 1 portion of Caulis Sargentodoxae of 1.5 parts of Caulis Sinomeniis of Caulis Spatholobi
1 part of 1 part of Caulis Polygoni Multiflori of 1 part of Caulis Lonicerae of Caulis Trachelospermi
1 part of 3 portions of Caulis Fibraureae of 1 part of Yunnan Caulis Spatholobi of Caulis Marsdeniae Tenacissimae
1.5 parts of the Radixs Astragali
Above-mentioned Chinese crude drug is dried and crushed into fine powder.Add an amount of adjuvant, mixing is granulated, and compacting is made in flakes.
Embodiment 7: the preparation of powder
Take by weighing these raw materials of traditional Chinese medicinal materials according to following consumption:
1.5 parts of 1 portion of Caulis Sargentodoxae of 1.5 parts of Caulis Sinomeniis of Caulis Spatholobi
1 part of 1 part of Caulis Polygoni Multiflori of 1 part of Caulis Lonicerae of Caulis Trachelospermi
1 part of 3 portions of Caulis Fibraureae of 1 part of Yunnan Caulis Spatholobi of Caulis Marsdeniae Tenacissimae
1.5 parts of the Radixs Astragali
Caulis Spatholobi, Yunnan Caulis Spatholobi are decocted with water 3 times, each 1.5 hours, filter, merging filtrate, evaporation and concentration is being dried and crushed into fine powder to the thick paste shape with Caulis Sinomenii, Caulis Sargentodoxae, Caulis Trachelospermi, Caulis Lonicerae, Caulis Polygoni Multiflori, Caulis Marsdeniae Tenacissimae, Caulis Fibraureae, the Radix Astragali, with above-mentioned thick paste mixing, drying is ground into fine powder and makes.
Embodiment 8: the preparation of powder
Take by weighing these raw materials of traditional Chinese medicinal materials according to following consumption:
1.5 parts of 1 portion of Caulis Sargentodoxae of 1.5 parts of Caulis Sinomeniis of Caulis Spatholobi
1 part of 1 part of Caulis Polygoni Multiflori of 1 part of Caulis Lonicerae of Caulis Trachelospermi
1 part of 3 portions of Caulis Fibraureae of 1 part of Yunnan Caulis Spatholobi of Caulis Marsdeniae Tenacissimae
1.5 parts of the Radixs Astragali
Above-mentioned Chinese crude drug is dried and crushed into fine powder, and mixing is made.
Embodiment 9: the preparation of capsule
Take by weighing these raw materials of traditional Chinese medicinal materials according to following consumption:
1.5 parts of 1 portion of Caulis Sargentodoxae of 1.5 parts of Caulis Sinomeniis of Caulis Spatholobi
1 part of 1 part of Caulis Polygoni Multiflori of 1 part of Caulis Lonicerae of Caulis Trachelospermi
1 part of 3 portions of Caulis Fibraureae of 1 part of Yunnan Caulis Spatholobi of Caulis Marsdeniae Tenacissimae
1.5 parts of the Radixs Astragali
Caulis Spatholobi, Yunnan Caulis Spatholobi are decocted with water 3 times, each 1.5 hours, filter, merging filtrate, evaporation and concentration are being dried and crushed into fine powder to the thick paste shape with Caulis Sinomenii, Caulis Sargentodoxae, Caulis Trachelospermi, Caulis Lonicerae, Caulis Polygoni Multiflori, Caulis Marsdeniae Tenacissimae, Caulis Fibraureae, the Radix Astragali, with above-mentioned thick paste mixing, drying is ground into fine powder, the hard capsule case of packing into.
Embodiment 10: capsular preparation
Take by weighing these raw materials of traditional Chinese medicinal materials according to following consumption:
1.5 parts of 1 portion of Caulis Sargentodoxae of 1.5 parts of Caulis Sinomeniis of Caulis Spatholobi
1 part of 1 part of Caulis Polygoni Multiflori of 1 part of Caulis Lonicerae of Caulis Trachelospermi
1 part of 3 portions of Caulis Fibraureae of 1 part of Yunnan Caulis Spatholobi of Caulis Marsdeniae Tenacissimae
1.5 parts of the Radixs Astragali
Above-mentioned Chinese crude drug is dried and crushed into fine powder, mixing, the hard capsule case of packing into.
Claims (6)
1. medicine for the treatment of oviduct obstructive sterility is characterized in that it is the medicament of being made by following weight proportion raw material and pharmaceutically acceptable excipient:
2. according to the medicine of the described treatment oviduct obstructive sterility of claim 1, wherein the weight proportion of each raw material is:
3. according to the medicine of the described treatment oviduct obstructive sterility of claim 1, wherein the weight proportion of each raw material is:
4. the preparation method of any one described medicine of claim 1～3 is characterized in that comprising the following steps:
(1) takes by weighing raw materials of traditional Chinese medicinal materials according to above-mentioned consumption;
(2) above-mentioned Chinese crude drug is dried and crushed into fine powder;
(3) above-mentioned fine powder is made various regular dosage forms with pharmaceutically acceptable excipient.
5. the preparation method of each described medicine of claim 1～3 is characterized in that comprising the following steps:
(1) takes by weighing raw materials of traditional Chinese medicinal materials according to above-mentioned consumption;
(2) Caulis Spatholobi, Yunnan Caulis Spatholobi are decocted with water 3 times, each 1.5 hours, filter, merging filtrate, evaporation and concentration is being dried and crushed into fine powder to the thick paste shape with Caulis Sinomenii, Caulis Sargentodoxae, Caulis Trachelospermi, Caulis Lonicerae, Caulis Polygoni Multiflori, Caulis Marsdeniae Tenacissimae, Caulis Fibraureae, the Radix Astragali, with above-mentioned thick paste mixing, drying is ground into fine powder;
(3) above-mentioned fine powder is made various regular dosage forms with pharmaceutically acceptable excipient.
6. the preparation method of each described medicine of claim 1～3 is characterized in that comprising the following steps:
(1) takes by weighing raw materials of traditional Chinese medicinal materials according to above-mentioned consumption;
(2) decoct with water three times, each 1～2 hour, filter, merging filtrate, evaporation and concentration is to the thick paste shape;
(3) above-mentioned thick paste shape is made various regular dosage forms with pharmaceutically acceptable excipient.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2010102154947A CN101862376B (en) | 2010-07-02 | 2010-07-02 | Medicament for treating oviduct obstructive infertility and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010102154947A CN101862376B (en) | 2010-07-02 | 2010-07-02 | Medicament for treating oviduct obstructive infertility and preparation method thereof |
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| CN101862376B true CN101862376B (en) | 2011-09-07 |
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| CN103893340B (en) * | 2014-03-26 | 2015-12-30 | 王景美 | A kind of Chinese medicine preparation for the treatment of cold blood stasis type oviduct obstructive sterility |
| CN118370781A (en) * | 2024-05-16 | 2024-07-23 | 广西壮族自治区中医药研究院 | Antioxidant and anti-inflammatory active component of sargentgloryvine stem, and preparation method and application thereof |
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