CN102727676A - Traditional Chinese herbal composition for treating allergic purpura as well as preparation method and application thereof - Google Patents
Traditional Chinese herbal composition for treating allergic purpura as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese herbal composition for treating allergic purpura and a method for preparing the same. The traditional Chinese herbal composition is prepared from 8 active pharmaceutical ingredients of suberect spatholobus stem, eclipta alba, leonurus, lithospermum, common ducksmeat herb, cortex dictamni, mulberry bark and schizonepeta according to a certain weight ratio. The traditional Chinese herbal composition has a good curative effect on allergic purpura.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition that is used to treat anaphylactoid purpura.
Background technology
Anaphylactoid purpura is called Heng-Shu syndrome (HSP) again; Be a kind of more common blood capillary allergy hemorrhage, because of body to some sensitizer generation allergy, cause capillary fragility and permeability to increase; Blood extravasation produces skin, mucosa and some organ hemorrhage.Other irritated performances of vasodilation, the urticaria etc. of can occurring together simultaneously.The reason that causes anaphylactoid purpura to take place is many, it is generally acknowledged with the absorption of antibacterial and viral infection, parasitic infection, animal proteinum and to take factor such as medicine relevant, and pathogeny does; Idiosyncrasy receives the influence of above-mentioned factor; And cause immune dysfunction, form immune complex and be deposited on capillary wall, and then cause extensive Capillaritis; Make capillary permeability increase blood extravasation.Anaphylactoid purpura can betide any age, is more common in teenager, and male's morbidity is slightly more than the women, and spring, autumn fall ill more.Clinical manifestation is skin petechia, ecchymosis, and pruritus is continuous, outbreak repeatedly, and prolonged difficulty is more; Often there is the upper respiratory tract infection history in 1-3 week before onset; In addition, anaphylactoid purpura if treatment is untimely, thoroughly or the state of an illness show effect repeatedly, finally can cause kidney damage, even develop into anaphy lactoid purpura nephritis, bring very big misery to the patient.
In the doctor trained in Western medicine clinical treatment,, often be difficult to confirm the definite cause of disease and inducement owing to the reason that causes anaphylactoid purpura is more; Therapeutic scheme is many with antihistaminic; Such as cimetidine, loratadine, chlorphenamine etc., and adrenocortical hormone, be main such as prednisolone acetate etc.When using these Drug therapys, the inherent side effect of medicine will be difficult to avoid.
According to Traditional Chinese medical theory, anaphylactoid purpura belongs to categories such as " mass formed by blood stasis ", " hemorrhagic disease with purpura ", " macule " basically.Its etiology and pathogenesis is concluded three aspects, and the one, exopathogen invasion and attack, the 2nd, injury due to diet, the 3rd, caused by liver and kidney deficiency, differentiation of symptoms and signs for classification of syndrome are divided into generally that wind heat hinders that network, gastrointestinal are damp and hot, bleeding due to blood-heat, QI failing to control blood, hyperactivity of fire caused by deficiency of YIN, the hepatic and renal YIN deficiency and deficiency of qi and blood etc.At present the traditional Chinese medical science is to the treatment of anaphylactoid purpura, generally to different differentiation of symptoms and signs for classification of syndrome, with eliminating evil be main, be basic method of treatment with the heat-clearing and toxic substances removing method of dispeling the wind, though these side's medicines produce effect, the prescription thinking is an a corner relatively all, curative effect is also unsatisfactory.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition that is used to treat anaphylactoid purpura.
The inventor provides following technical scheme through years of researches and clinical practice:
A kind of Chinese medicine composition that is used to treat anaphylactoid purpura, the crude drug of said Chinese medicine composition consists of:
Caulis Spatholobi 20-40 weight portion, Herba Ecliptae 10-25 weight portion, Herba Leonuri 10-25 weight portion, Radix Arnebiae (Radix Lithospermi) 5-15 weight portion, Herba Spirodelae grass 5-15 weight portion, Cortex Dictamni 5-15 weight portion, Cortex Mori 5-15 weight portion, Herba Schizonepetae 5-10 weight portion.
The optimized technical scheme according to the present invention, the crude drug of said Chinese medicine composition consists of:
Caulis Spatholobi 40 weight portions, Herba Ecliptae 20 weight portions, Herba Leonuri 20 weight portions, Radix Arnebiae (Radix Lithospermi) 12 weight portions, Herba Spirodelae grass 12 weight portions, Cortex Dictamni 12 weight portions, Cortex Mori 12 weight portions, Herba Schizonepetae 8 weight portions.
Another optimized technical scheme according to the present invention, the crude drug of said Chinese medicine composition consists of:
Caulis Spatholobi 35 weight portions, Herba Ecliptae 15 weight portions, Herba Leonuri 15 weight portions, Radix Arnebiae (Radix Lithospermi) 10 weight portions, Herba Spirodelae grass 10 weight portions, Cortex Dictamni 10 weight portions, Cortex Mori 10 weight portions, Herba Schizonepetae 6 weight portions.
Another optimized technical scheme according to the present invention, the crude drug of said Chinese medicine composition consists of:
Caulis Spatholobi 30 weight portions, Herba Ecliptae 10 weight portions, Herba Leonuri 10 weight portions, Radix Arnebiae (Radix Lithospermi) 10 weight portions, Herba Spirodelae grass 10 weight portions, Cortex Dictamni 10 weight portions, Cortex Mori 10 weight portions, Herba Schizonepetae 10 weight portions.
The present invention also provides the method for preparing of said Chinese medicine composition.
Preferred embodiment a kind of according to the present invention, the method for preparing of said Chinese medicine composition comprises:
Get said eight flavor medical materials, extracting in water 1-4 time, each amount of water are that 5-10 doubly measures (by weight, down together), and each extraction time is 1-3 hour, filters, and merging filtrate concentrates, and the gained extract dry is pulverized.The gained extract powder can further add conventional adjuvant or not add adjuvant, processes pharmaceutically acceptable dosage form.
Preferably, the method for preparing of said Chinese medicine composition comprises:
Get said eight flavor medical materials, extracting in water 3 times, amount of water are followed successively by 10,8,8 times of amounts, and extraction time was followed successively by 2,1,1 hours, filtered, and merging filtrate concentrates, and the gained extract dry is pulverized.The gained extract powder can further add conventional adjuvant or not add adjuvant, processes pharmaceutically acceptable dosage form.
According to the present invention another preferred embodiment, the method for preparing of said Chinese medicine composition comprises:
Get Caulis Spatholobi, Cortex Dictamni with 30-90% (v/v, down together) alcohol heating reflux extraction 1-4 time, each quantity of solvent is that 2-7 doubly measures, and each extraction time is 1-3 hour; Filter, merging filtrate concentrates behind the filtrate recycling ethanol, gets alcohol-extracted extract, and is subsequent use; Medicinal residues mix with Herba Ecliptae, Herba Leonuri, Radix Arnebiae (Radix Lithospermi), Herba Spirodelae grass, Cortex Mori, Herba Schizonepetae, extracting in water 1-4 time, and each amount of water is doubly measured for 2-10 by weight, and each extraction time is 1-3 hour; Filter, merging filtrate, filtrating simmer down to extractum mixes with said alcohol-extracted extract, and drying is pulverized.The gained extract powder can further add conventional adjuvant or not add adjuvant, processes pharmaceutically acceptable dosage form.
Preferably, the method for preparing of said Chinese medicine composition comprises:
Get Caulis Spatholobi, Cortex Dictamni with 70% alcohol heating reflux extraction 3 times, solubilization dosage is followed successively by 7,7,5 times of amounts by weight, and extraction time was followed successively by 2,1.5,1 hours; Filter, merging filtrate concentrates behind the filtrate recycling ethanol, gets alcohol-extracted extract, and is subsequent use; Medicinal residues mix with Herba Ecliptae, Herba Leonuri, Radix Arnebiae (Radix Lithospermi), Herba Spirodelae grass, Cortex Mori, Herba Schizonepetae, and extracting in water 2 times, amount of water are followed successively by 10,8 times of amounts by weight, and extraction time was followed successively by 2,1.5 hours; Filter, merging filtrate, filtrating simmer down to extractum mixes with said alcohol-extracted extract, and drying is pulverized.The gained extract powder can further add conventional adjuvant or not add adjuvant, processes pharmaceutically acceptable dosage form.
Preferably, said dosage form is tablet, pill, capsule, granule or oral liquid.
The present invention also provides the application of said Chinese medicine composition in the medicine of preparation treatment anaphylactoid purpura.
The inventor thinks; No matter anaphylactoid purpura to be treated belongs to any Chinese medical discrimination typing; Fiber crops as worm ant when the symptom of its appearance such as skin, the time have be dispersed in, the time have large stretch of symptom that takes place, is prone to repeatedly all to meet the characteristic of ailment said due to cold or exposure, the change of wind person benefaction number is not calmly had an itch.And pathogenic wind visitor table basic reason is the blood deficiency anemia of body self; Cause body skin to lose and support, venation is lost and is supported, and causes stirring-up of pathogenic wind in the interior resulting from deficiency; Evil objective skin is met the symptom that exopathogen (as suffer from cold be heated, air is unclean) or internal injury (not good like diet, malnutrition due to parasitic infestation, lose blood) all are prone to cause anaphylactoid purpura.And anaphylactoid purpura is often shown effect after fatigue and is increased the weight of, increase the weight of at afternoon or night, and often with simple and unadorned, the onyx cervical carcinoma with cachexia of spiritlessness and weakness, shortness of breath and palpitation, lustreless complexion, the night symptom such as dreaminess of sleeping also meet the characteristic of blood deficiency anemia.Therefore, the inventor carries out prescription according to the thinking of " control wind and control blood earlier, the blood sector-style is from going out ", obtains Chinese medicine composition of the present invention, wherein:
Caulis Spatholobi bitter in the mouth, sweet, warm in nature, return liver, kidney channel, be generally used in the prescription of diseases such as rheumatic arthralgia of menoxenia and orthopaedics of gynecological.Chinese medicine composition of the present invention is got Caulis Spatholobi and is used to treat anaphylactoid purpura as monarch drug, because of sweet in the mouth, and sweet then benefit, this medicine can be enriched blood, and is used for the blood deficiency dull yellowish colored skin, again because of returning Liver Channel, liver storing blood, the liver benefiting benefit blood; Hardship is then fallen in the nature and flavor, and Wen Zetong helps the catharsis function of liver, lowering the adverse flow of QI, and promoting blood circulation is active, thereby eradicates the source of purpura morbidity from etiology and pathogenesis.
Herba Ecliptae sweet in the mouth, acid, cool in nature, go into liver, kidney channel, have the merit of removing heat from blood, hemostasis, the kidney invigorating, tonifying YIN.Herba Leonuri is bitter, hot, is slightly cold, and returns liver, pericardium channel, both can invigorate blood circulation, and gets the merit of its inducing diuresis to remove edema again, develops into henoch Schonlein purpura nephritis with the Polyglucan purpura.This two flavors medicine is assisted the monarch drug Caulis Spatholobi to enrich blood jointly and is invigorated blood circulation as ministerial drug.
Radix Arnebiae (Radix Lithospermi) sweet in the mouth, salty, cold in nature, GUIXIN, Liver Channel have removing heat from blood, invigorate blood circulation, and the merit of detoxifcation rash is used for that heat in blood poison is contained, macule is purple black, assists the monarch and his subjects' rash of detoxifying.Herba Spirodelae grass acrid in the mouth, cold in nature, go into lung meridian, the hot carbuncle of row when controlling, macule is not passed through, wind heat pain rash, skin pruritus, edema etc. assist the monarch and his subjects' rash to end skin itching.The Cortex Dictamni bitter in the mouth is salty, and is cold in nature, returns lung, urinary bladder channel, and because of it walks lung, urinary bladder channel, the freeing lung-Qi and eliminating damp detumescence helps skin purpura redness to disappear as early as possible with it.Cortex Mori sweet in the mouth, little hardship, return lung, spleen channel, cure mainly dyspnea and cough due to lung-heat, diseases caused by retention of fluid stops lung, the distension dyspnea with rapid respiration, and kind especially purte the white and relieving asthma and cough is controlled the lung-heat cough with asthma; Lung governing skin and hair is so with the method for letting out lung-fire, to remove the wind heat of skin, eliminate purpura.Simultaneously, return Herba Spirodelae grass, Cortex Dictamni and the Cortex Mori of lung meridian also can alleviate anaphylactoid purpura usually with upper respiratory tract infection symptoms.More than four flavor assistants help the monarch and his subjects to dispel ailment said due to cold or exposure, help purpura to disappear.
The Herba Schizonepetae acrid in the mouth, slightly warm in nature, hot and dry partially, return lung, Liver Channel is diaphoretic medicine, be again walk blood system remove the wind medicine, as messenger drug, all medicines of guiding arrive the flesh table with it, the diffusing wind that induces sweat, rash is with the treatment purpura.
More than all medicines, monarch is shared, enriches blood and dispels the wind, BIAO and BEN is controlled altogether, to treatment anaphylactoid purpura curative effect very significantly.
The inventor is in secular traditional Chinese medical science research and clinical practice; Said Chinese medicine composition is used for the treatment of anaphylactoid purpura; During actual therapeutic, according to the difference of patient's practical situation, under the prerequisite of the composition principle that does not depart from said Chinese medicine composition; The consumption of medical material of respectively distinguishing the flavor of in the said Chinese medicine composition is adjusted in said scope, has all obtained very notable therapeutic effect.Clinical practice confirms; Said Chinese medicine composition; No matter traditional decocting decoction still extracts the Chinese patent medicine of preparation through method for optimizing, no matter uses separately, still with the Western medicine drug combination; Said Chinese medicine composition has all been obtained unexpected good result in the treatment of anaphylactoid purpura, and does not see any toxic and side effects.
The specific embodiment
With clinical test results the therapeutical effect of Chinese medicine composition of the present invention to anaphylactoid purpura is described below, but the present invention do not constituted any restriction.
1. diagnostic criteria:
Western medicine diagnose is: 1-3 week the upper respiratory tract infection history is arranged before (1) onset; (2) occur the skin purpura repeatedly, stomachache can be arranged, have blood in stool (abdomen type), arthralgia (joint type) and hematuria, edema (kidney type); (3) purpura is more common in around lower limb far-end, the ankle joint, and the part erythra can show as pimple, urticaria, angioedema etc.; (4) hemogram is normal, and accidental eosinophilic granulocyte increases; (5) visible red cell, albumen and granular cast in the urine; (6) bleeding time, clotting time platelet count all normal, but capillary fragility test is positive.
Tcm diagnosis is: purpura is not prolongedly healed repeatedly, and time is dispersed in, the time large stretch of the generation arranged, the tired back outbreak of being everlasting increases the weight of, afternoon or night increase the weight of, scratching where it itches constantly can be with spiritlessness and weakness, shortness of breath and palpitation, the few China of face is simple and unadorned, onyx cervical carcinoma with cachexia, the dreaminess of sleeping night; Pale tongue, thin white fur of tongue, thready pulse or number.
2. clinical data
Typing 87 routine patients all meet above-mentioned anaphylactoid purpura diagnostic criteria altogether, are divided into matched group and treatment group at random.Matched group 40 examples wherein, male's 29 examples, women's 11 examples, age 4-32 year, average 18 years old, the shortest person of the course of disease 4 days, elder 9 months, average 3 months, simple type 24 examples, abdomen type 6 examples, joint type 8 examples, kidney type 2 examples; 47 examples are organized in treatment, male's 32 examples, women's 15 examples, age 3.5-29 year, average 17 years old, the shortest person of the course of disease 3 days, elder 8 months, average 3.5 months, simple type 31 examples, abdomen type 5 examples, joint type 8 examples, kidney type 3 examples; Two groups on sex, age, the state of an illness, the course of disease through statistical procedures there are no significant difference, have comparability.
3. Therapeutic Method
Matched group: (1) oral chlorphenamine, each 4mg that is grown up, every day 3 times, children's 0.35mg/kg every day, divide 3-4 time oral; (2) the each 0.1g of oral vitamin C sheet, every day 3 times; (3) add with prednisone sheet 0.5-1mg/kgd with joint type, abdomen type or kidney type person, divide 3 times oral, decrement after the remission.
The treatment group: Chinese medicine composition of the present invention is processed granule, and method for preparing is: get Caulis Spatholobi 600g, Herba Ecliptae 200g, Herba Leonuri 200g; Radix Arnebiae (Radix Lithospermi) 200g, Herba Spirodelae grass 200g, Cortex Dictamni 200g; Cortex Mori 200g, Herba Schizonepetae 200g, wherein; Caulis Spatholobi, Cortex Dictamni extract 3 times with 70% alcohol heating reflux, and solubilization dosage is followed successively by 7,7,5 times of amounts, and extraction time was followed successively by 2,1.5,1 hours; Filter, merging filtrate reclaims ethanol, and relative density is 1.31～1.35 extractum during solution concentration to 60 ℃, and is subsequent use; Medicinal residues mix with Cortex Mori, Herba Schizonepetae, Radix Arnebiae (Radix Lithospermi), Herba Leonuri, Herba Spirodelae grass and Herba Ecliptae, and extracting in water 2 times, amount of water are followed successively by 10,8 times of amounts, and extraction time was followed successively by 2,1.5 hours; Filter, merging filtrate, relative density is 1.32～1.35 extractum when being concentrated into 60 ℃, mixes with above-mentioned alcohol-extracted extract; Drying is ground into fine powder, adds an amount of soluble dextrins and 0.01% cyclamate to total amount 1000g; Mixing, with alcohol granulation, dry below 40 ℃; Granulate, packing is processed granule.This granule of every gram is equivalent to the 2.0g crude drug.Adult every day 3 times, each 8g; Children's takes according to the body weight decrement.
More than treatment was a course of treatment in 1 week, added up curative effect after treating 4 courses of treatment.
4. criterion of therapeutical effect
" disease of tcm diagnosis criterion of therapeutical effect " with reference to State Administration of Traditional Chinese Medicine's promulgation in 1994 drafted criterion of therapeutical effect.
Cure: ecchymosis and various double disease all disappear, and do not have other complication, and the lab testing result is all in normal range;
Take a turn for the better: ecchymosis point obviously reduces, and various double diseases alleviate, and the lab testing result is all in normal range;
Invalid: ecchymosis point and various double disease do not have improvement or increase the weight of, and the lab testing result does not have obvious improvement.
5. therapeutic outcome
Matched group: cure 10 examples, 22 examples that take a turn for the better, invalid 8 examples, total effective rate is 80%; The treatment group: cure 29 examples, 16 examples that take a turn for the better, invalid 2 examples, total effective rate is 95.74%.
6. conclusion
The present composition is for various anaphylactoid purpura, and the treatment like simple type, abdomen type, joint type, kidney type etc. has all obtained excellent curative; Total effective rate is up to 95.74%; Be higher than western medicine group, especially for simple type and the short patient of disease time, onset is rapid; Cure rate is high, and does not show any toxic and side effects.
Below through embodiment the present composition is described further, but said embodiment is not construed as limiting the invention.
Embodiment
Embodiment 1
Prescription: Caulis Spatholobi 800g, Herba Ecliptae 400g, Herba Leonuri 400g, Radix Arnebiae (Radix Lithospermi) 240g, Herba Spirodelae grass 240g, Cortex Dictamni 240g, Cortex Mori 240g, Herba Schizonepetae 160g.
Method for preparing: get above eight flavor medical materials, extracting in water 3 times, amount of water are followed successively by 10,8,8 times of amounts; Extraction time was followed successively by 2,1,1 hours, filtered merging filtrate; Relative density is 1.32～1.35 extractum when being evaporated to 60 ℃, and drying under reduced pressure is ground into fine powder; Add an amount of carboxymethyl starch sodium, microcrystalline Cellulose and magnesium stearate, compacting promptly gets in flakes.
Embodiment 2
Prescription: Caulis Spatholobi 700g, Herba Ecliptae 300g, Herba Leonuri 300g, Radix Arnebiae (Radix Lithospermi) 200g, Herba Spirodelae grass 200g, Cortex Dictamni 200g, Cortex Mori 200g, Herba Schizonepetae 120g.
Method for preparing: Caulis Spatholobi, Cortex Dictamni extract 3 times with 90% alcohol heating reflux, and solubilization dosage is followed successively by 7,5,5 times of amounts, and extraction time was followed successively by 3,2,1 hours; Filter, merging filtrate reclaims ethanol, and relative density is 1.20～1.30 extractum during solution concentration to 60 ℃, and is subsequent use; Medicinal residues mix with Cortex Mori, Herba Schizonepetae, Radix Arnebiae (Radix Lithospermi), Herba Leonuri, Herba Spirodelae grass and Herba Ecliptae, and extracting in water 2 times, amount of water are followed successively by 10,8 times of amounts, and extraction time was followed successively by 2,1.5 hours; Filter, merging filtrate, relative density is 1.32～1.35 extractum when being concentrated into 60 ℃, mixes with above-mentioned alcohol-extracted extract, and drying is ground into fine powder, adds an amount of carboxymethyl starch sodium, microcrystalline Cellulose and magnesium stearate, and compacting promptly gets in flakes.
Embodiment 3
Prescription: Caulis Spatholobi 600g, Herba Ecliptae 200g, Herba Leonuri 200g, Radix Arnebiae (Radix Lithospermi) 200g, Herba Spirodelae grass 200g, Cortex Dictamni 200g, Cortex Mori 200g, Herba Schizonepetae 200g.
Method for preparing: above eight flavors, Caulis Spatholobi, Cortex Dictamni extract 3 times with 70% alcohol heating reflux, and solubilization dosage is followed successively by 7,7,5 times of amounts, and extraction time was followed successively by 2,1.5,1 hours; Filter, merging filtrate reclaims ethanol, and relative density is 1.31～1.35 extractum during solution concentration to 60 ℃, and is subsequent use; Medicinal residues mix with Cortex Mori, Herba Schizonepetae, Radix Arnebiae (Radix Lithospermi), Herba Leonuri, Herba Spirodelae grass and Herba Ecliptae, and extracting in water 2 times, amount of water are followed successively by 10,8 times of amounts, and extraction time was followed successively by 3,1.5 hours; Filter, merging filtrate, relative density is 1.31～1.35 extractum when being concentrated into 60 ℃, mixes with above-mentioned alcohol-extracted extract, and drying is ground into fine powder, and with alcohol granulation, hard capsule is dressed up in oven dry.
Embodiment 4
Prescription: Caulis Spatholobi 800g, Herba Ecliptae 500g, Herba Leonuri 500g, Radix Arnebiae (Radix Lithospermi) 100g, Herba Spirodelae grass 100g, Cortex Dictamni 100g, Cortex Mori 100g, Herba Schizonepetae 100g.
Method for preparing: above eight flavors, Caulis Spatholobi, Cortex Dictamni extract 4 times with 30% alcohol heating reflux, and each quantity of solvent is followed successively by 7,7,5,2 times of amounts, and each extraction time was followed successively by 3,2,1,1 hours; Filter, merging filtrate reclaims ethanol, and relative density is 1.31～1.35 extractum during solution concentration to 60 ℃, and is subsequent use; Medicinal residues mix with Cortex Mori, Herba Schizonepetae, Radix Arnebiae (Radix Lithospermi), Herba Leonuri, Herba Spirodelae grass and Herba Ecliptae, extracting in water 4 times, and each amount of water is followed successively by 8,8,6,2 times of amounts, and each extraction time was followed successively by 2,1,1,1 hours; Filter, merging filtrate, relative density is 1.20～1.30 extractum when being concentrated into 60 ℃, mixes with above-mentioned alcohol-extracted extract, drying is pulverized, the general pill of processing, drying, packing.
Embodiment 5
Prescription: Caulis Spatholobi 700g, Herba Ecliptae 400g, Herba Leonuri 400g, Radix Arnebiae (Radix Lithospermi) 300g, Herba Spirodelae grass 300g, Cortex Dictamni 300g, Cortex Mori 300g, Herba Schizonepetae 200g.
Method for preparing: above eight flavors, Caulis Spatholobi, Cortex Dictamni extract 2 times with 50% alcohol heating reflux, and each quantity of solvent is followed successively by 7,5 times of amounts, and each extraction time was followed successively by 2,1.5 hours; Filter, merging filtrate reclaims ethanol, and relative density is 1.20～1.25 extractum during solution concentration to 60 ℃, and is subsequent use; Medicinal residues mix with Cortex Mori, Herba Schizonepetae, Radix Arnebiae (Radix Lithospermi), Herba Leonuri, Herba Spirodelae grass and Herba Ecliptae, extracting in water 2 times, and each amount of water is followed successively by 10,8 times of amounts, and each extraction time was followed successively by 1.5,1 hours; Filter, merging filtrate, relative density is 1.20～1.25 extractum when being concentrated into 60 ℃, mixes with above-mentioned alcohol-extracted extract, and drying is ground into fine powder, mixes with an amount of soybean oil, Cera Flava, and pressing is processed soft capsule.
Embodiment 6
Prescription: Caulis Spatholobi 400g, Herba Ecliptae 200g, Herba Leonuri 200g, Radix Arnebiae (Radix Lithospermi) 100g, Herba Spirodelae grass 100g, Cortex Dictamni 100g, Cortex Mori 100g, Herba Schizonepetae 100g.
Method for preparing: above eight flavors, Caulis Spatholobi, Cortex Dictamni extract 3 times with alcohol heating reflux respectively, and concentration of alcohol is followed successively by 70%, 70%, 50%, and each quantity of solvent is followed successively by 7,5,5 times of amounts, and each extraction time is 2,1,1 hours; Filter, merging filtrate reclaims ethanol, and relative density is 1.31～1.35 extractum during solution concentration to 60 ℃, and is subsequent use; Medicinal residues mix with Cortex Mori, Herba Schizonepetae, Radix Arnebiae (Radix Lithospermi), Herba Leonuri, Herba Spirodelae grass and Herba Ecliptae, extracting in water 3 times, and each amount of water is followed successively by 9,7,7 times of amounts, and each extraction time is 3,1,1 hours; Filter, merging filtrate, relative density is 1.31～1.35 extractum when being concentrated into 60 ℃, mixes with above-mentioned alcohol-extracted extract, drying is ground into fine powder, with alcohol granulation, adds an amount of magnesium stearate mixing, the hard capsule of packing into.
Claims (10)
1. Chinese medicine composition that is used to treat anaphylactoid purpura, the crude drug of said Chinese medicine composition consists of:
Caulis Spatholobi 20-40 weight portion, Herba Ecliptae 10-25 weight portion, Herba Leonuri 10-25 weight portion, Radix Arnebiae (Radix Lithospermi) 5-15 weight portion, Herba Spirodelae grass 5-15 weight portion, Cortex Dictamni 5-15 weight portion, Cortex Mori 5-15 weight portion, Herba Schizonepetae 5-10 weight portion.
2. Chinese medicine composition according to claim 1 is characterized in that, the crude drug of said Chinese medicine composition consists of:
Caulis Spatholobi 40 weight portions, Herba Ecliptae 20 weight portions, Herba Leonuri 20 weight portions, Radix Arnebiae (Radix Lithospermi) 12 weight portions, Herba Spirodelae grass 12 weight portions, Cortex Dictamni 12 weight portions, Cortex Mori 12 weight portions, Herba Schizonepetae 8 weight portions.
3. Chinese medicine composition according to claim 1 is characterized in that, the crude drug of said Chinese medicine composition consists of:
Caulis Spatholobi 35 weight portions, Herba Ecliptae 15 weight portions, Herba Leonuri 15 weight portions, Radix Arnebiae (Radix Lithospermi) 10 weight portions, Herba Spirodelae grass 10 weight portions, Cortex Dictamni 10 weight portions, Cortex Mori 10 weight portions, Herba Schizonepetae 6 weight portions.
4. Chinese medicine composition according to claim 1 is characterized in that, the crude drug of said Chinese medicine composition consists of:
Caulis Spatholobi 30 weight portions, Herba Ecliptae 10 weight portions, Herba Leonuri 10 weight portions, Radix Arnebiae (Radix Lithospermi) 10 weight portions, Herba Spirodelae grass 10 weight portions, Cortex Dictamni 10 weight portions, Cortex Mori 10 weight portions, Herba Schizonepetae 10 weight portions.
5. according to each described Chinese medicine composition of claim 1-4, it is characterized in that the method for preparing of said Chinese medicine composition comprises:
Get said eight flavor medical materials, extracting in water 1-4 time, each amount of water is doubly measured for 5-10 by weight, and each extraction time is 1-3 hour, filters, and merging filtrate concentrates, and the gained extract dry is pulverized.
6. Chinese medicine composition according to claim 5 is characterized in that, the method for preparing of said Chinese medicine composition comprises:
Get said eight flavor medical materials, extracting in water 3 times, amount of water are followed successively by 10,8,8 times of amounts by weight, and extraction time was followed successively by 2,1,1 hours, filtered, and merging filtrate concentrates, and the gained extract dry is pulverized.
7. according to each described Chinese medicine composition of claim 1-4, it is characterized in that the method for preparing of said Chinese medicine composition comprises:
Get Caulis Spatholobi, Cortex Dictamni with 30-90% alcohol heating reflux extraction 1-4 time, each quantity of solvent is doubly measured for 2-7 by weight, and each extraction time is 1-3 hour; Filter, merging filtrate concentrates behind the filtrate recycling ethanol, gets alcohol-extracted extract, and is subsequent use; Medicinal residues mix with Herba Ecliptae, Herba Leonuri, Radix Arnebiae (Radix Lithospermi), Herba Spirodelae grass, Cortex Mori, Herba Schizonepetae, extracting in water 1-4 time, and each amount of water is doubly measured for 2-10 by weight, and each extraction time is 1-3 hour; Filter, merging filtrate, filtrating simmer down to extractum mixes with said alcohol-extracted extract, and drying is pulverized.
8. Chinese medicine composition according to claim 7 is characterized in that, the method for preparing of said Chinese medicine composition comprises:
Get Caulis Spatholobi, Cortex Dictamni with 70% alcohol heating reflux extraction 3 times, solubilization dosage is followed successively by 7,7,5 times of amounts by weight, and extraction time was followed successively by 2,1.5,1 hours; Filter, merging filtrate concentrates behind the filtrate recycling ethanol, gets alcohol-extracted extract, and is subsequent use; Medicinal residues mix with Herba Ecliptae, Herba Leonuri, Radix Arnebiae (Radix Lithospermi), Herba Spirodelae grass, Cortex Mori, Herba Schizonepetae, and extracting in water 2 times, amount of water are followed successively by 10,8 times of amounts by weight, and extraction time was followed successively by 2,1.5 hours; Filter, merging filtrate, filtrating simmer down to extractum mixes with said alcohol-extracted extract, and drying is pulverized.
9. according to each described Chinese medicine composition of claim 1-4, it is characterized in that said Chinese medicine composition is processed tablet, pill, capsule, granule or oral liquid.
10. according to the application of each described Chinese medicine composition of claim 1-9 in the medicine of preparation treatment anaphylactoid purpura.
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