CN102727676B - Traditional Chinese herbal composition for treating allergic purpura as well as preparation method and application thereof - Google Patents
Traditional Chinese herbal composition for treating allergic purpura as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese herbal composition for treating allergic purpura and a method for preparing the same. The traditional Chinese herbal composition is prepared from 8 active pharmaceutical ingredients of suberect spatholobus stem, eclipta alba, leonurus, lithospermum, common ducksmeat herb, cortex dictamni, mulberry bark and schizonepeta according to a certain weight ratio. The traditional Chinese herbal composition has a good curative effect on allergic purpura.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition that is used for the treatment of anaphylactoid purpura and its production and use.
Background technology
Anaphylactoid purpura is called again Heng-Shu syndrome (HSP), it is a kind of more common blood capillary allergy hemorrhage, because body is to some sensitizer generation allergy, cause capillary fragility and permeability to increase, blood extravasation, produces skin, mucosa and some organ hemorrhage.Other irritated performances of vasodilation, the urticaria etc. of can simultaneously occurring together.The reason that causes anaphylactoid purpura to occur is many, it is generally acknowledged relevant with factors such as the absorption of antibacterial and viral infection, parasitic infection, animal proteinum and drug administrations, pathogeny is, idiosyncrasy is subject to the impact of above-mentioned factor, and cause immune dysfunction, form immune complex and be deposited on capillary wall, and then causing extensive Capillaritis, capillary permeability is increased, blood extravasation.Anaphylactoid purpura can betide any age, is more common in teenager, and male's morbidity is slightly more than women, and spring, autumn fall ill more.Clinical manifestation is skin petechia, ecchymosis, and pruritus is continuous, outbreak repeatedly, and prolonged difficulty is more; Before onset, in 1-3 week, often have upper respiratory tract infection history; In addition, if anaphylactoid purpura is treated not in time, thorough or Relapse rate outbreak, finally can cause kidney damage, even develop into anaphy lactoid purpura nephritis, to patient, bring very big misery.
In doctor trained in Western medicine clinical treatment, owing to causing, the reason of anaphylactoid purpura is more, is often difficult to determine the definite cause of disease and inducement, therapeutic scheme is mainly with antihistaminic, such as cimetidine, loratadine, chlorphenamine etc., and adrenocortical hormone, such as prednisolone acetate etc. is main.While using these Drug therapys, the intrinsic side effect of medicine will be difficult to avoid.
According to Traditional Chinese medical theory, anaphylactoid purpura belongs to the categories such as " mass formed by blood stasis ", " hemorrhagic disease with purpura ", " macule " substantially.Its etiology and pathogenesis has been summed up three aspects, and the one, exopathogen invasion and attack, the 2nd, injury due to diet, the 3rd, caused by liver and kidney deficiency, differentiation of symptoms and signs for classification of syndrome is generally divided into that wind heat hinders that network, gastrointestinal are damp and hot, bleeding due to blood-heat, QI failing to control blood, hyperactivity of fire caused by deficiency of YIN, the hepatic and renal YIN deficiency and deficiency of qi and blood etc.The at present treatment of the traditional Chinese medical science to anaphylactoid purpura, general for different differentiation of symptoms and signs for classification of syndrome, take eliminating evilly as main, the heat-clearing and toxic substances removing of take dispels the wind method as basic therapy, though these side's medicines produce effect, prescription thinking is an a corner relatively all, curative effect is also unsatisfactory.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition that is used for the treatment of anaphylactoid purpura.
Inventor, through years of researches and clinical practice, provides following technical scheme:
A Chinese medicine composition that is used for the treatment of anaphylactoid purpura, the crude drug of described Chinese medicine composition consists of:
Caulis Spatholobi 20-40 weight portion, Herba Ecliptae 10-25 weight portion, Herba Leonuri 10-25 weight portion, Radix Arnebiae (Radix Lithospermi) 5-15 weight portion, Herba Spirodelae grass 5-15 weight portion, Cortex Dictamni 5-15 weight portion, Cortex Mori 5-15 weight portion, Herba Schizonepetae 5-10 weight portion.
The preferred technical scheme according to the present invention, the crude drug of described Chinese medicine composition consists of:
Caulis Spatholobi 40 weight portions, Herba Ecliptae 20 weight portions, Herba Leonuri 20 weight portions, Radix Arnebiae (Radix Lithospermi) 12 weight portions, Herba Spirodelae grass 12 weight portions, Cortex Dictamni 12 weight portions, Cortex Mori 12 weight portions, Herba Schizonepetae 8 weight portions.
Another preferred technical scheme according to the present invention, the crude drug of described Chinese medicine composition consists of:
Caulis Spatholobi 35 weight portions, Herba Ecliptae 15 weight portions, Herba Leonuri 15 weight portions, Radix Arnebiae (Radix Lithospermi) 10 weight portions, Herba Spirodelae grass 10 weight portions, Cortex Dictamni 10 weight portions, Cortex Mori 10 weight portions, Herba Schizonepetae 6 weight portions.
Another preferred technical scheme according to the present invention, the crude drug of described Chinese medicine composition consists of:
Caulis Spatholobi 30 weight portions, Herba Ecliptae 10 weight portions, Herba Leonuri 10 weight portions, Radix Arnebiae (Radix Lithospermi) 10 weight portions, Herba Spirodelae grass 10 weight portions, Cortex Dictamni 10 weight portions, Cortex Mori 10 weight portions, Herba Schizonepetae 10 weight portions.
The present invention also provides the preparation method of described Chinese medicine composition.
Preferred embodiment a kind of according to the present invention, the preparation method of described Chinese medicine composition comprises:
Get described eight taste medical materials, extracting in water 1-4 time, each amount of water is that 5-10 doubly measures (by weight, lower same), each extraction time is 1-3 hour, filters, merging filtrate, concentrated, gained extract dry, pulverizes.Gained extract powder can further add conventional adjuvant or not add adjuvant, makes pharmaceutically acceptable dosage form.
Preferably, the preparation method of described Chinese medicine composition comprises:
Get described eight taste medical materials, extracting in water 3 times, amount of water is followed successively by 10,8,8 times of amounts, and extraction time is followed successively by 2,1,1 hours, filters, merging filtrate, concentrated, gained extract dry, pulverizes.Gained extract powder can further add conventional adjuvant or not add adjuvant, makes pharmaceutically acceptable dosage form.
According to the present invention another preferred embodiment, the preparation method of described Chinese medicine composition comprises:
Get Caulis Spatholobi, Cortex Dictamni with 30-90% (v/v, lower same) alcohol heating reflux extraction 1-4 time, each quantity of solvent is that 2-7 doubly measures, and each extraction time is 1-3 hour; Filter, merging filtrate, concentrated after filtrate recycling ethanol, obtain alcohol-extracted extract, standby; Medicinal residues mix with Herba Ecliptae, Herba Leonuri, Radix Arnebiae (Radix Lithospermi), Herba Spirodelae grass, Cortex Mori, Herba Schizonepetae, extracting in water 1-4 time, and each amount of water is doubly measured for 2-10 by weight, and each extraction time is 1-3 hour; Filter, merging filtrate, filtrate simmer down to extractum, mixes with described alcohol-extracted extract, dry, pulverize.Gained extract powder can further add conventional adjuvant or not add adjuvant, makes pharmaceutically acceptable dosage form.
Preferably, the preparation method of described Chinese medicine composition comprises:
Get Caulis Spatholobi, Cortex Dictamni with 70% alcohol heating reflux extraction 3 times, solubilization dosage is followed successively by 7,7,5 times of amounts by weight, and extraction time is followed successively by 2,1.5,1 hours; Filter, merging filtrate, concentrated after filtrate recycling ethanol, obtain alcohol-extracted extract, standby; Medicinal residues mix with Herba Ecliptae, Herba Leonuri, Radix Arnebiae (Radix Lithospermi), Herba Spirodelae grass, Cortex Mori, Herba Schizonepetae, extracting in water 2 times, and amount of water is followed successively by 10,8 times of amounts by weight, and extraction time is followed successively by 2,1.5 hours; Filter, merging filtrate, filtrate simmer down to extractum, mixes with described alcohol-extracted extract, dry, pulverize.Gained extract powder can further add conventional adjuvant or not add adjuvant, makes pharmaceutically acceptable dosage form.
Preferably, described dosage form is tablet, pill, capsule, granule or oral liquid.
The present invention also provides the application of described Chinese medicine composition in the medicine of preparation treatment anaphylactoid purpura.
Inventor thinks, no matter anaphylactoid purpura to be treated belongs to any Syndrome Differentiation of Traditional Chinese Medicine, the symptom of its appearance as skin time fiber crops as worm ant, time have be dispersed in, time have large stretch ofly occur, feature that easily symptom repeatedly all meets ailment said due to cold or exposure, the change of wind person benefaction number, does not calmly have an itch.And pathogenic wind visitor table basic reason is the blood deficiency anemia of body self, causing body skin to lose supports, venation is lost and is supported, and cause stirring-up of pathogenic wind in the interior resulting from deficiency, evil objective skin, meets the symptom that exopathogen (be heated as suffered from cold, air unclean) or internal injury (as diet is not good, malnutrition due to parasitic infestation, lose blood) all easily cause anaphylactoid purpura.And anaphylactoid purpura is often shown effect and is increased the weight of after fatigue, increase the weight of at afternoon or night, and often with simple and unadorned, the onyx cervical carcinoma with cachexia of spiritlessness and weakness, shortness of breath and palpitation, lustreless complexion, the night symptoms such as dreaminess of sleeping also meet the feature of blood deficiency anemia.Therefore, inventor carries out prescription according to the thinking of " control wind and first control blood, blood wind is from going out ", obtains Chinese medicine composition of the present invention, wherein:
Caulis Spatholobi bitter in the mouth, sweet, warm in nature, return liver, kidney channel, be generally used in the prescription of the menoxenia of gynecological and the diseases such as rheumatic arthralgia of orthopaedics.Chinese medicine composition of the present invention is got Caulis Spatholobi and is used for the treatment of anaphylactoid purpura as monarch drug, because of sweet in the mouth, and sweet benefit, this medicine can be enriched blood, for blood deficiency dull yellowish colored skin, again because returning Liver Channel, liver storing blood, the liver benefiting benefit blood; In nature and flavor, hardship is fallen, and Wen Zetong helps the catharsis function of liver, lowering the adverse flow of QI, and promoting blood circulation is active, thereby eradicates the source of purpura morbidity from etiology and pathogenesis.
Herba Ecliptae sweet in the mouth, acid, cool in nature, enter liver, kidney channel, there is the merit of removing heat from blood, hemostasis, the kidney invigorating, tonifying YIN.Herba Leonuri is bitter, pungent, is slightly cold, and returns liver, pericardium channel, both can invigorate blood circulation, and gets again the merit of its inducing diuresis to remove edema, with Polyglucan purpura, develops into henoch Schonlein purpura nephritis.This two tastes medicine, as ministerial drug, is jointly assisted monarch drug Caulis Spatholobi to enrich blood and is invigorated blood circulation.
Radix Arnebiae (Radix Lithospermi) sweet in the mouth, salty, cold in nature, GUIXIN, Liver Channel, have removing heat from blood, invigorate blood circulation, the merit of removing toxic substances rash, for heat in blood poison contain, macule purple is black, assists the monarch and his subjects' rash of detoxifying.Herba Spirodelae grass acrid in the mouth, cold in nature, enter lung meridian, the hot carbuncle of row while controlling, macule is not saturating, wind heat pain rash, skin pruritus, edema etc., assist the monarch and his subjects' rash to stop skin itching.Cortex Dictamni bitter in the mouth is salty, cold in nature, returns lung, urinary bladder channel, and because it walks lung, urinary bladder channel, freeing lung-Qi and eliminating damp detumescence, helps skin purpura redness to disappear as early as possible with it.Cortex Mori sweet in the mouth, micro-hardship, return lung, spleen channel, cure mainly dyspnea and cough due to lung-heat, diseases caused by retention of fluid stops lung, distension dyspnea with rapid respiration, and especially kind purte the white and relieving asthma and cough, controls lung-heat cough with asthma; Lung governing skin and hair, so by the method for letting out lung-fire, to remove the wind heat of skin, eliminate purpura.Meanwhile, return Herba Spirodelae grass, Cortex Dictamni and the Cortex Mori of lung meridian also can alleviate anaphylactoid purpura usually with upper respiratory tract infection symptoms.Above four taste assistants help the monarch and his subjects to dispel ailment said due to cold or exposure, help purpura to disappear.
Herba Schizonepetae acrid in the mouth, slightly warm in nature, pungent and partially dry, return lung, Liver Channel, is diaphoretic medicine, be again walk blood system remove wind medicine, with it, as making medicine, guide all medicines to arrive flesh table, the loose wind that induces sweat, rash, to treat purpura.
All medicines above, monarch shares, and enriches blood and dispels the wind, and specimen is controlled altogether, very remarkable to treatment anaphylactoid purpura curative effect.
Inventor is in long-term traditional Chinese medical science research and clinical practice, treatment by described Chinese medicine composition for anaphylactoid purpura, during actual therapeutic, according to the difference of patient's practical situation, under the prerequisite of composition principle that does not depart from described Chinese medicine composition, in described Chinese medicine composition, the consumption of ingredients is adjusted in described scope, has all obtained very significant therapeutic effect.Clinical practice confirms, described Chinese medicine composition, no matter traditional decocting decoction still extracts the Chinese patent medicine of preparation through method for optimizing, no matter use separately, or with Western medicine drug combination, described Chinese medicine composition has all been obtained unexpected good result in the treatment of anaphylactoid purpura, and has no any toxic and side effects.
The specific embodiment
With clinical test results, the therapeutical effect of Chinese medicine composition of the present invention to anaphylactoid purpura is described below, but the present invention do not formed to any restriction.
1. diagnostic criteria:
Western medicine diagnose is: before (1) onset, 1-3 week have upper respiratory tract infection history; (2) repeatedly there is skin purpura, can have stomachache, have blood in stool (abdomen type), arthralgia (joint type) and hematuria, an edema (kidney type); (3) purpura is more common in around Lower Distal Extremities, ankle joint, and part erythra can show as pimple, urticaria, angioedema etc.; (4) hemogram is normal, and accidental eosinophilic granulocyte increases; (5) visible red cell, albumen and granular cast in urine; (6) bleeding time, clotting time platelet count all normal, but capillary fragility test is positive.
Tcm diagnosis is: purpura repeatedly, is not prolongedly healed, and time is dispersed in, time have large stretch of generation, be everlasting tired after outbreak increase the weight of, afternoon or night increase the weight of, scratching where it itches constantly can be with spiritlessness and weakness, shortness of breath and palpitation, the few China of face is simple and unadorned, onyx cervical carcinoma with cachexia, the dreaminess of sleeping night; Pale tongue, thin white fur of tongue, thready pulse or number.
2. clinical data
The routine patient of typing 87, all meets above-mentioned anaphylactoid purpura diagnostic criteria altogether, is divided at random matched group and treatment group.Matched group 40 examples wherein, male's 29 examples, women's 11 examples, age 4-32 year, average 18 years old, the shortest person of the course of disease 4 days, elder 9 months, average 3 months, simple type 24 examples, abdomen type 6 examples, joint type 8 examples, kidney type 2 examples; Treatment group 47 examples, male's 32 examples, women's 15 examples, age 3.5-29 year, average 17 years old, the shortest person of the course of disease 3 days, elder 8 months, average 3.5 months, simple type 31 examples, abdomen type 5 examples, joint type 8 examples, kidney type 3 examples; Two groups of differences of learn processing by statistics in sex, age, the state of an illness, the course of disease that there are no significant, have comparability.
3. Therapeutic Method
Matched group: (1) oral chlorphenamine, each 4mg that is grown up, every day 3 times, children's 0.35mg/kg every day, minute 3-4 time is oral; (2) the each 0.1g of oral vitamin C sheet, every day 3 times; (3) with joint type, abdomen type or kidney type person, add with prednisone sheet 0.5-1mg/kgd, minutes 3 times oral, decrement after remission.
Treatment group: Chinese medicine composition granulation of the present invention agent, preparation method is: get Caulis Spatholobi 600g, Herba Ecliptae 200g, Herba Leonuri 200g, Radix Arnebiae (Radix Lithospermi) 200g, Herba Spirodelae grass 200g, Cortex Dictamni 200g, Cortex Mori 200g, Herba Schizonepetae 200g, wherein, Caulis Spatholobi, Cortex Dictamni extract 3 times with 70% alcohol heating reflux, solubilization dosage is followed successively by 7,7,5 times of amounts, and extraction time is followed successively by 2,1.5,1 hours; Filter, merging filtrate, reclaims ethanol, and the extractum that when solution is concentrated into 60 ℃, relative density is 1.31～1.35 is standby; Medicinal residues mix with Cortex Mori, Herba Schizonepetae, Radix Arnebiae (Radix Lithospermi), Herba Leonuri, Herba Spirodelae grass and Herba Ecliptae, extracting in water 2 times, and amount of water is followed successively by 10,8 times of amounts, and extraction time is followed successively by 2,1.5 hours; Filter merging filtrate, the extractum that while being concentrated into 60 ℃, relative density is 1.32～1.35, mix with above-mentioned alcohol-extracted extract, dry, pulverize into fine powder, add appropriate soluble dextrins and 0.01% cyclamate to total amount 1000g, mix, with alcohol granulation, 40 ℃ following dry, granulate, packing, granulation agent.Every gram of this granule is equivalent to 2.0g crude drug.Adult every day 3 times, each 8g; Children's takes according to body weight decrement.
More than treating 1 week is a course for the treatment of, adds up curative effect after treating 4 courses for the treatment of.
4. criterion of therapeutical effect
The < < disease of tcm Standardization of diagnosis and curative effect > > promulgating for 1994 with reference to State Administration of Traditional Chinese Medicine drafts criterion of therapeutical effect.
Cure: ecchymosis and various double disease all disappear, and without other complication, laboratory examination results is all within normal range;
Take a turn for the better: ecchymosis point obviously reduces, and various double diseases alleviate, and laboratory examination results is all within normal range;
Invalid: ecchymosis point and various double disease are without improving or increasing the weight of, and laboratory examination results is not improved.
5. therapeutic outcome
Matched group: cure 10 examples, 22 examples that take a turn for the better, invalid 8 examples, total effective rate is 80%; Treatment group: cure 29 examples, 16 examples that take a turn for the better, invalid 2 examples, total effective rate is 95.74%.
6. conclusion
The present composition is for various anaphylactoid purpura, as the treatment of simple type, abdomen type, joint type, kidney type etc., all obtained good therapeutic effect, total effective rate is up to 95.74%, higher than western medicine group, especially, for simple type and the shorter patient of disease time, onset is rapid, cure rate is high, and does not show any toxic and side effects.
By the following examples the present composition is described further, but described embodiment is not construed as limiting the invention.
embodiment
Embodiment 1
Prescription: Caulis Spatholobi 800g, Herba Ecliptae 400g, Herba Leonuri 400g, Radix Arnebiae (Radix Lithospermi) 240g, Herba Spirodelae grass 240g, Cortex Dictamni 240g, Cortex Mori 240g, Herba Schizonepetae 160g.
Preparation method: get above eight taste medical materials, extracting in water 3 times, amount of water is followed successively by 10,8,8 times of amounts, and extraction time is followed successively by 2,1,1 hours, filter, merging filtrate, the extractum that while being evaporated to 60 ℃, relative density is 1.32～1.35, drying under reduced pressure, be ground into fine powder, add appropriate carboxymethyl starch sodium, microcrystalline Cellulose and magnesium stearate, compacting in flakes, obtains.
Embodiment 2
Prescription: Caulis Spatholobi 700g, Herba Ecliptae 300g, Herba Leonuri 300g, Radix Arnebiae (Radix Lithospermi) 200g, Herba Spirodelae grass 200g, Cortex Dictamni 200g, Cortex Mori 200g, Herba Schizonepetae 120g.
Preparation method: Caulis Spatholobi, Cortex Dictamni extract 3 times with 90% alcohol heating reflux, and solubilization dosage is followed successively by 7,5,5 times of amounts, and extraction time is followed successively by 3,2,1 hours; Filter, merging filtrate, reclaims ethanol, and the extractum that when solution is concentrated into 60 ℃, relative density is 1.20～1.30 is standby; Medicinal residues mix with Cortex Mori, Herba Schizonepetae, Radix Arnebiae (Radix Lithospermi), Herba Leonuri, Herba Spirodelae grass and Herba Ecliptae, extracting in water 2 times, and amount of water is followed successively by 10,8 times of amounts, and extraction time is followed successively by 2,1.5 hours; Filter, merging filtrate, the extractum that while being concentrated into 60 ℃, relative density is 1.32～1.35, mixes with above-mentioned alcohol-extracted extract, dry, pulverize into fine powder, adds appropriate carboxymethyl starch sodium, microcrystalline Cellulose and magnesium stearate, and compacting in flakes, obtains.
Embodiment 3
Prescription: Caulis Spatholobi 600g, Herba Ecliptae 200g, Herba Leonuri 200g, Radix Arnebiae (Radix Lithospermi) 200g, Herba Spirodelae grass 200g, Cortex Dictamni 200g, Cortex Mori 200g, Herba Schizonepetae 200g.
Preparation method: above eight tastes, Caulis Spatholobi, Cortex Dictamni extract 3 times with 70% alcohol heating reflux, and solubilization dosage is followed successively by 7,7,5 times of amounts, and extraction time is followed successively by 2,1.5,1 hours; Filter, merging filtrate, reclaims ethanol, and the extractum that when solution is concentrated into 60 ℃, relative density is 1.31～1.35 is standby; Medicinal residues mix with Cortex Mori, Herba Schizonepetae, Radix Arnebiae (Radix Lithospermi), Herba Leonuri, Herba Spirodelae grass and Herba Ecliptae, extracting in water 2 times, and amount of water is followed successively by 10,8 times of amounts, and extraction time is followed successively by 3,1.5 hours; Filter, merging filtrate, the extractum that while being concentrated into 60 ℃, relative density is 1.31～1.35, mixes with above-mentioned alcohol-extracted extract, dry, pulverize into fine powder, with alcohol granulation, dries, and dresses up hard capsule.
Embodiment 4
Prescription: Caulis Spatholobi 800g, Herba Ecliptae 500g, Herba Leonuri 500g, Radix Arnebiae (Radix Lithospermi) 100g, Herba Spirodelae grass 100g, Cortex Dictamni 100g, Cortex Mori 100g, Herba Schizonepetae 100g.
Preparation method: above eight tastes, Caulis Spatholobi, Cortex Dictamni extract 4 times with 30% alcohol heating reflux, and each quantity of solvent is followed successively by 7,7,5,2 times of amounts, and each extraction time is followed successively by 3,2,1,1 hours; Filter, merging filtrate, reclaims ethanol, and the extractum that when solution is concentrated into 60 ℃, relative density is 1.31～1.35 is standby; Medicinal residues mix with Cortex Mori, Herba Schizonepetae, Radix Arnebiae (Radix Lithospermi), Herba Leonuri, Herba Spirodelae grass and Herba Ecliptae, extracting in water 4 times, and each amount of water is followed successively by 8,8,6,2 times of amounts, and each extraction time is followed successively by 2,1,1,1 hours; Filter, merging filtrate, the extractum that while being concentrated into 60 ℃, relative density is 1.20～1.30, mixes with above-mentioned alcohol-extracted extract, dry, pulverize, the general pill of making, dry, packing.
Embodiment 5
Prescription: Caulis Spatholobi 700g, Herba Ecliptae 400g, Herba Leonuri 400g, Radix Arnebiae (Radix Lithospermi) 300g, Herba Spirodelae grass 300g, Cortex Dictamni 300g, Cortex Mori 300g, Herba Schizonepetae 200g.
Preparation method: above eight tastes, Caulis Spatholobi, Cortex Dictamni extract 2 times with 50% alcohol heating reflux, and each quantity of solvent is followed successively by 7,5 times of amounts, and each extraction time is followed successively by 2,1.5 hours; Filter, merging filtrate, reclaims ethanol, and the extractum that when solution is concentrated into 60 ℃, relative density is 1.20～1.25 is standby; Medicinal residues mix with Cortex Mori, Herba Schizonepetae, Radix Arnebiae (Radix Lithospermi), Herba Leonuri, Herba Spirodelae grass and Herba Ecliptae, extracting in water 2 times, and each amount of water is followed successively by 10,8 times of amounts, and each extraction time is followed successively by 1.5,1 hours; Filter, merging filtrate, the extractum that while being concentrated into 60 ℃, relative density is 1.20～1.25, mixes with above-mentioned alcohol-extracted extract, dry, pulverize into fine powder, mixes with appropriate soybean oil, Cera Flava, and pressing is made soft capsule.
Embodiment 6
Prescription: Caulis Spatholobi 400g, Herba Ecliptae 200g, Herba Leonuri 200g, Radix Arnebiae (Radix Lithospermi) 100g, Herba Spirodelae grass 100g, Cortex Dictamni 100g, Cortex Mori 100g, Herba Schizonepetae 100g.
Preparation method: above eight tastes, Caulis Spatholobi, Cortex Dictamni extract 3 times with alcohol heating reflux respectively, and concentration of alcohol is followed successively by 70%, 70%, 50%, and each quantity of solvent is followed successively by 7,5,5 times of amounts, and each extraction time is 2,1,1 hours; Filter, merging filtrate, reclaims ethanol, and the extractum that when solution is concentrated into 60 ℃, relative density is 1.31～1.35 is standby; Medicinal residues mix with Cortex Mori, Herba Schizonepetae, Radix Arnebiae (Radix Lithospermi), Herba Leonuri, Herba Spirodelae grass and Herba Ecliptae, extracting in water 3 times, and each amount of water is followed successively by 9,7,7 times of amounts, and each extraction time is 3,1,1 hours; Filter, merging filtrate, the extractum that while being concentrated into 60 ℃, relative density is 1.31～1.35, mixes with above-mentioned alcohol-extracted extract, dry, pulverize into fine powder, with alcohol granulation, adds appropriate magnesium stearate to mix, and packs hard capsule into.
Claims (10)
1. a Chinese medicine composition that is used for the treatment of anaphylactoid purpura, the crude drug of described Chinese medicine composition consists of:
Caulis Spatholobi 20-40 weight portion, Herba Ecliptae 10-25 weight portion, Herba Leonuri 10-25 weight portion, Radix Arnebiae (Radix Lithospermi) 5-15 weight portion, Herba Spirodelae grass 5-15 weight portion, Cortex Dictamni 5-15 weight portion, Cortex Mori 5-15 weight portion, Herba Schizonepetae 5-10 weight portion.
2. Chinese medicine composition according to claim 1, is characterized in that, the crude drug of described Chinese medicine composition consists of:
Caulis Spatholobi 40 weight portions, Herba Ecliptae 20 weight portions, Herba Leonuri 20 weight portions, Radix Arnebiae (Radix Lithospermi) 12 weight portions, Herba Spirodelae grass 12 weight portions, Cortex Dictamni 12 weight portions, Cortex Mori 12 weight portions, Herba Schizonepetae 8 weight portions.
3. Chinese medicine composition according to claim 1, is characterized in that, the crude drug of described Chinese medicine composition consists of:
Caulis Spatholobi 35 weight portions, Herba Ecliptae 15 weight portions, Herba Leonuri 15 weight portions, Radix Arnebiae (Radix Lithospermi) 10 weight portions, Herba Spirodelae grass 10 weight portions, Cortex Dictamni 10 weight portions, Cortex Mori 10 weight portions, Herba Schizonepetae 6 weight portions.
4. Chinese medicine composition according to claim 1, is characterized in that, the crude drug of described Chinese medicine composition consists of:
Caulis Spatholobi 30 weight portions, Herba Ecliptae 10 weight portions, Herba Leonuri 10 weight portions, Radix Arnebiae (Radix Lithospermi) 10 weight portions, Herba Spirodelae grass 10 weight portions, Cortex Dictamni 10 weight portions, Cortex Mori 10 weight portions, Herba Schizonepetae 10 weight portions.
5. according to the Chinese medicine composition described in claim 1-4 any one, it is characterized in that, the preparation method of described Chinese medicine composition comprises:
Get described eight taste medical materials, extracting in water 1-4 time, each amount of water is doubly measured for 5-10 by weight, and each extraction time is 1-3 hour, filters, merging filtrate, concentrated, gained extract dry, pulverizes.
6. Chinese medicine composition according to claim 5, is characterized in that, the preparation method of described Chinese medicine composition comprises:
Get described eight taste medical materials, extracting in water 3 times, amount of water is followed successively by 10,8,8 times of amounts by weight, and extraction time is followed successively by 2,1,1 hours, filters, merging filtrate, concentrated, gained extract dry, pulverizes.
7. according to the Chinese medicine composition described in claim 1-4 any one, it is characterized in that, the preparation method of described Chinese medicine composition comprises:
Get Caulis Spatholobi, Cortex Dictamni with 30-90% alcohol heating reflux extraction 1-4 time, each quantity of solvent is doubly measured for 2-7 by weight, and each extraction time is 1-3 hour; Filter, merging filtrate, concentrated after filtrate recycling ethanol, obtain alcohol-extracted extract, standby; Medicinal residues mix with Herba Ecliptae, Herba Leonuri, Radix Arnebiae (Radix Lithospermi), Herba Spirodelae grass, Cortex Mori, Herba Schizonepetae, extracting in water 1-4 time, and each amount of water is doubly measured for 2-10 by weight, and each extraction time is 1-3 hour; Filter, merging filtrate, filtrate simmer down to extractum, mixes with described alcohol-extracted extract, dry, pulverize.
8. Chinese medicine composition according to claim 7, is characterized in that, the preparation method of described Chinese medicine composition comprises:
Get Caulis Spatholobi, Cortex Dictamni with 70% alcohol heating reflux extraction 3 times, solubilization dosage is followed successively by 7,7,5 times of amounts by weight, and extraction time is followed successively by 2,1.5,1 hours; Filter, merging filtrate, concentrated after filtrate recycling ethanol, obtain alcohol-extracted extract, standby; Medicinal residues mix with Herba Ecliptae, Herba Leonuri, Radix Arnebiae (Radix Lithospermi), Herba Spirodelae grass, Cortex Mori, Herba Schizonepetae, extracting in water 2 times, and amount of water is followed successively by 10,8 times of amounts by weight, and extraction time is followed successively by 2,1.5 hours; Filter, merging filtrate, filtrate simmer down to extractum, mixes with described alcohol-extracted extract, dry, pulverize.
9. according to the Chinese medicine composition described in claim 1-4 any one, it is characterized in that, described Chinese medicine composition is made tablet, pill, capsule, granule or oral liquid.
10. the application in the medicine of preparation treatment anaphylactoid purpura according to the Chinese medicine composition described in claim 1-9 any one.
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