CN104606347A - Traditional Chinese medicine preparation for treating postmenopausal osteoporosis with hepatic and renal yin deficiency - Google Patents
Traditional Chinese medicine preparation for treating postmenopausal osteoporosis with hepatic and renal yin deficiency Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating postmenopausal osteoporosis with hepatic and renal yin deficiency. The traditional Chinese medicine preparation is prepared from the following raw medicinal materials including glossy privet fruits, prepared rehmannia roots, fructus psoraleae, semen cuscutae, eucommia ulmoides leaves, radix paeoniae alba, leavesof leatherleaf mahonia and twotooth achyranthes roots. The raw medicinal materials can be prepared into various dosage forms. According to the traditional Chinese medicine preparation disclosed by the invention, with pure natural traditional Chinese medicines as the raw medicinal materials, verified by clinical tests for many years, the traditional Chinese medicine preparation has the efficacies of nourishing liver and kidney and strengthening tendons and bones, is capable of improving the bone mineral density and the bone metabolism, increasing sex hormone level and treating both manifestation and root cause of a disease while improving symptoms, is small in amount of traditional Chinese medicine in a composing prescription, does not have side or toxic effect and is safe and effective.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine preparation for the treatment of liver-kidney yin deficiency postmenopausal osteoporosis.
Background technology
Postmenopausal osteoporosis (Post menopausal osteoporosis, PMOP) is one of osteoporosis common type, and its pathogenesis and women's Postmenopausal Ovaries hypofunction, body inner estrogen level significantly declines closely related.The bone metabolism negative balance caused along with estrogen deficiency, the destruction of bone resorption accelerated bone micro structure, osseous tissue rebuilds obstacle, and bone amount lowers, thus affects bone strength, increases bone fragility, finally causes osteoporosis.The cause of disease of postmenopausal osteoporosis, except menopause factor, affects by the factor such as age of meuopause, body weight again, is the commonly encountered diseases of middle aged and aged women, frequently-occurring disease.
The primary disease traditional Chinese medical science is classified as " atrophic debility of bones " category, and the traditional Chinese medical science thinks that primary disease has natural endowment not enough more, and the day after tomorrow takes good care of imbalance, and prolonged illness is lost and controlled, old decay, the improper initiation of medication, its pathogenesis be mainly suffer from a deficiency of the kidney, insufficiency of the spleen, blood stasis, stagnation of liver-QI.To suffer from a deficiency of the kidney the principal element of the morbidity being osteoporosis.The kidney being the origin of congenital constitution, store essential substances and raw marrow.Suffer from a deficiency of the kidney then deficiency of kidney-essence, essence does not fill marrow, and marrow is become homeless foster, causes bone soft not hard, occurs " atrophic debility of bones ".
" woman is congenital with liver ", therefore have again saying of " aging of people, liver is guide ", so liver comes into one's own day by day with old and feeble relation.Liver is organ of general, main catharsis, store blood.The catharsis function of liver is normal, and blood and body fluid are just able to normal operation and defeated cloth metabolism, taste ability normally transporting and digesting food precise and tiny.If liver deficiency of YIN-blood, then muscles and bones losing is moistened foster, " Plain Questions ancient times innocence opinion " cloud: " irritability decline then the tendon being unable to move ", and muscle is attached to bone, and the injury of tendon and muscle then bone is soft, and stride is not hard, the disease of walking shakiness and showing.Embody liver to muscles and bones moisten support effect.Blood stored in the liver, kidney storing essence, the traditional Chinese medical science has " essence and blood sharing the same origin ", the saying of " The liver and the kidney have a common source ", the vital essence in kidney is filled and contained that to depend on moistening of blood foster.If deficiency of liver-blood, then can cause deficiency of the kidney, deficiecny of liver-YIN, also can cause deficiency of kidney-YIN.
Chinese medicine osteoporosis determined curative effect, and side effect is little, treatment focuses on integrally-regulated, transfers endogenous cause of ill, acts on the links of developing osteoporosis, finally gets to and suppresses bone resorption and increase osteoplastic effect.Application Chinese medicine osteoporosis has western modern medicine and treats incomparable advantage, has a extensive future.
Summary of the invention
The object of the invention is for the treatment of liver-kidney yin deficiency postmenopausal osteoporosis provides a kind of Chinese medicine preparation, this Chinese medicine preparation selects natural Chinese medicines raw material, through the checking of clinical trial for many years, has effect of good nourishing the liver and kidney, bone and muscle strengthening.This Chinese medicine preparation flavour of a drug number is less, has no side effect, safe and effective.
For achieving the above object, the present invention adopts following technical scheme:
Treat a Chinese medicine preparation for liver-kidney yin deficiency postmenopausal osteoporosis, it is that medicinal raw material is made by Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, Fructus Psoraleae, Semen Cuscutae, Folium Eucommiae, the Radix Paeoniae Alba, Folium Mahoniae, Radix Achyranthis Bidentatae.
The present invention is in the selection of medicinal raw material, according to pathogenic factor and the mechanism thereof of liver-kidney yin deficiency postmenopausal osteoporosis, take invigorating the liver and kidney, bone and muscle strengthening, nourishing YIN and supplementing blood Chinese medicine or have concurrently simultaneously, be aided with the Chinese medicine such as kidney-replenishing, heat clearing away flavour of a drug, or YAOJING and power are specially or a medicine multiple-effect, in conjunction with the summary of clinical experience for many years, compatibility is rigorous, through repeatedly testing following preferred version:
Treat a Chinese medicine preparation for liver-kidney yin deficiency postmenopausal osteoporosis, it is characterized in that described Chinese medicine preparation is made up of the medicinal raw material of following weight portion: Fructus Ligustri Lucidi 13-18 part, Radix Rehmanniae Preparata 16-21 part, Fructus Psoraleae 11-15 part, Semen Cuscutae 9-15 part, Folium Eucommiae 21-26 part, Radix Paeoniae Alba 14-19 part, Folium Mahoniae 9-15 part, Radix Achyranthis Bidentatae 8-13 part.
Further preferably, treat a Chinese medicine preparation for liver-kidney yin deficiency postmenopausal osteoporosis, it is characterized in that described Chinese medicine preparation is made up of the medicinal raw material of following weight portion: Fructus Ligustri Lucidi 15-17 part, Radix Rehmanniae Preparata 18-21 part, Fructus Psoraleae 12-14 part, Semen Cuscutae 11-15 part, Folium Eucommiae 23-26 part, Radix Paeoniae Alba 15-18 part, Folium Mahoniae 11-13 part, Radix Achyranthis Bidentatae 9-11 part.
The preferred version further optimized: a kind of Chinese medicine preparation for the treatment of liver-kidney yin deficiency postmenopausal osteoporosis, is characterized in that described Chinese medicine preparation is made up of the medicinal raw material of following weight portion: Fructus Ligustri Lucidi 16 parts, Radix Rehmanniae Preparata 20 parts, Fructus Psoraleae 13 parts, Semen Cuscutae 13 parts, Folium Eucommiae 25 parts, the Radix Paeoniae Alba 17 parts, Folium Mahoniae 12 parts, Radix Achyranthis Bidentatae 10 parts.
According to traditional Chinese medical science invigorating the kidney and strengthening the bones method, treatment syndrome of yin deficiency of liver and kidney.Prescription is medicinal raw material by Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, Fructus Psoraleae, Semen Cuscutae, Folium Eucommiae, the Radix Paeoniae Alba, Folium Mahoniae, Radix Achyranthis Bidentatae, Fructus Ligustri Lucidi and Radix Rehmanniae Preparata compatibility in side, Fructus Ligustri Lucidi is sweet cool, and merit is apt to the moon of invigorating the liver and kidney, the sweet temperature of Radix Rehmanniae Preparata, merit is apt to nourishing YIN and supplementing blood, and beneficial essence fills out marrow, and Wen Liang develops simultaneously, not only nourishing YIN and supplementing blood but also beneficial essence filled out marrow, Liver and kidney material is filled, and vertigo and tinnitus, soreness of the waist and knees, the interior-heat disease such as to quench one's thirst then is separated, and is monarch drug.Radix Paeoniae Alba easing the affected liver to relieve pain, nourish blood yin fluid astringing, and liver must support the work of then blood, and liver blood foot is then had a headache dizzy, and hypochondriac pain must be separated, and is ministerial drug.Semen Cuscutae nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, enters spleen channel warming spleen and stopping diarrha, not only tonifying kidney-yin but also kidney tonifying sun; Fructus Psoraleae is warm in nature supporing yang, and to get the meaning of " treating YIN within YANG ", yin yang complementarity like this, positive cloudy helping and biochemical infinite, YIN matched with sufficient YANG making living things fully vivid is adjuvant drug.Folium Eucommiae invigorating the liver and kidney, bone and muscle strengthening, makes to enjoy excellent health, Folium Mahoniae heat clearing away tonify deficiency, in case close door to stay bandit, Radix Achyranthis Bidentatae invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards, tool is adjuvant.
We's YAOJING and power is special, a medicine multiple-effect, compatibility is rigorous, plays effect of nourishing the liver and kidney, bone and muscle strengthening altogether, suits pathogenesis, has both treated sick, again can prevention of diseae, for liver-kidney yin deficiency postmenopausal osteoporosis treating both the principal and secondary aspects of a disease.
According to Chinese medicine Historical Data Data About and clinical verification, the pharmacologically active of above-mentioned medical material is as follows.
Fructus Ligustri Lucidi: sweet, bitter, cold.Return liver, kidney channel.Function cures mainly: nourishing the liver and kidney, improving eyesight black hair.For vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision.
Radix Rehmanniae Preparata: sweet, tepor.Return liver, kidney channel.Function cures mainly: nourishing YIN and supplementing blood, and beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.
Fructus Psoraleae: pungent, bitter, temperature.Return kidney, spleen channel.Function cures mainly: warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.
Semen Cuscutae: sweet, temperature.Return liver,kidney,spleen warp.Function cures mainly: nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.
Folium Eucommiae: pungent, warm in nature.Enter liver, kidney channel.Function cures mainly: invigorating the liver and kidney, bone and muscle strengthening, blood pressure lowering.Main lumbar and back pain, sufficient knees soreness is weak, hypertension.
The Radix Paeoniae Alba: bitter, sour, is slightly cold.Return liver, spleen channel.Function cures mainly: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
Folium Mahoniae: bitter, cold.Return liver, stomach, lung, large intestine channel.Function cures mainly: heat clearing away tonify deficiency; Dampness; Removing toxic substances.Main pulmonary tuberculosis hemoptysis; Osteopyrexia and fever; Dizziness and tinnitus; Waist soreness; Jaundice due to damp-heat; Leukorrhagia; Dysentery; Anemopyretic cold; Conjunctival congestion and swelling pain; Carbuncle skin infection.
Radix Achyranthis Bidentatae: bitter, sour is flat.Return liver, kidney channel.Function cures mainly: invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.For soreness of waist and knee joint, muscles and bones is unable, amenorrhea lump in the abdomen, dizziness due to hyperactivity of liver-YANG.
In order to express Chinese medicine preparation of the present invention better, Chinese medicine preparation of the present invention can be prepared into dosage form conventional clinically, such as powder, pill, sublimed preparation, unguentum, granule, oral liquid, syrup, tablet, capsule etc.
Preferably, the dosage form of Chinese medicine preparation of the present invention is preferably granule, tablet or capsule.
Present invention also offers a kind of preparation method of Chinese medicine preparation for the treatment of liver-kidney yin deficiency postmenopausal osteoporosis described above, it is characterized in that comprising the following steps: each medicinal raw material taking recipe quantity, merge, decoct with water twice, first time adds water as the 5-7 times amount of medical material weight, decoct 2.5-3.0 hour, second time adds water as the 3-5 times amount of medical material weight, decoct 2-2.5 hour, collecting decoction, when being evaporated to 60 DEG C, relative density is 1.05-1.20, adding ethanol makes the volume ratio of alcohol content be 45-60%, stir, hold over night, filter, filtrate reduced in volume reclaims ethanol, be condensed into thick paste, add appropriate amount of auxiliary materials, mixing, dry, prepare by field of Chinese medicines preparation common process.
For showing the therapeutic effect of Chinese medicine preparation of the present invention to liver-kidney yin deficiency postmenopausal osteoporosis, the present inventor has carried out clinical observation to 100 routine cases, and existing report is as follows.
1, physical data: 100 routine patients are observed in this research altogether, is my institute's department of endocrinology outpatient service and inpatient in October ,-2013 in April, 2012,47 ~ 67 years old age, 58.3 ± 4.6 years old mean age, average menopause 7.5 ± 4.37.During all patients all meet, Western medicine diagnose standard and inclusive criteria, in treatment group: matched group=1:1 ratio generates random assortment serial number, according to medical order, by 100 routine patient's random packet, wherein treatment group, each 50 examples of matched group, two groups of patient's physical data no significant difference (P > 0.05), have comparability.
2, diagnostic criteria:
Western medicine diagnose: dual energy X-ray absorptiometry measuring instrument (QDR-4000 type, HOLOGIC company of the U.S. produce), the bone amount of recommending with WHO lower than two standard deviations of same sex population's peak bone mass for diagnostic criteria.
Differential diagnosis in tcm: to draft this research syndrome of yin deficiency of liver and kidney standard as follows: primary symptom: 1. soreness of the waist and knees or pain in conjunction with clinical with reference to " new Chinese medicine guideline of clinical investigations " (Zheng Xiao cornel, Chinese science and technology publishing house: 2002.5:357); 2. tired few power, dizzy margins of eyelids.Secondary disease: 1. tinnitus is forgetful; 2. insomnia and dreamful sleep; 3. dry pharynx dryness of the tongue; 4. hypochondriac pain; 5. dysphoria with feverish sensation in the chest palms and soles, spontaneous sweating.Tongue arteries and veins: red tongue, answers less thin or light, thready and rapid pulse.Primary symptom 2+secondary disease 2 can be made a definite diagnosis in conjunction with tongue arteries and veins.Syndrome Scale quantitative criteria: primary symptom standards of grading are: without-0 point; Gently-2 points; In-4 points; Heavy-6 points.Secondary disease standards of grading are: without-0 point; Gently-1 point; In-2 points; Heavy-3 points.
Clinical manifestation: the many places chronic pains such as back are cardinal symptom.
3, exclusion standard: patient causes the various endocrinopathy persons (as Cushing's disease, hyperthyroidism, hyperparathyroidism, Hypothyroidism, diabetes etc.) of secondary osteoporosis; Other serious disease interference bone metabolism person; Fracture person is had in 1 year; Treatments period generation fracture person.
4, inclusive criteria: meet doctor trained in Western medicine diagnosis of osteoporosis standard; Meet the diagnostic criteria of Liver of TCM syndrome of deficiency of kidney yin; Postmenopausal women between 55 years old-70 years old age, has independent behavior ability person; Signature Informed Consent Form.
5, Therapeutic Method: treatment group: the Traditional Chinese medicine preparation capsule (0.35g, every containing crude drug 1.42g) of the embodiment of the present invention 1, every day 2 times, sooner or later respectively once, each 3-4 grain 14 days is a course for the treatment of, takes 6 courses for the treatment of continuously; Matched group: Western medicine one line standard therapy, Gaierqi D (vitamin D3 and calcium carbonate) (Wyeth pharmaceuticals, every sheet calcic 600mg, vitamin D 125 iu), 1 times/day, each 1, Allan phosphoric acid (Beijing Wan Sheng pharmaceutcal corporation, Ltd), at early at least 30 minutes before the meal every day used 200ml warm water delivery service on an empty stomach, a 10mg, 1 time on the one, take simultaneously, take 6 courses for the treatment of continuously.
6, parameters for observation on effect: (1) clinical main related symptoms: the symptoms such as lumbar and back pain, soreness of the waist and knees, tired few power, margins of eyelids, tinnitus, lower limb pain, lower limb flaccidity are weak, every 2 the course for the treatment of observed and recorded 1 time; (2) relevant physico-chemical examination: serum calcium, phosphorus, estradiol level, each inspection record 1 time before and after treatment; (3) bone densitometry: (B ultrasonic measures calcaneus BMD, represents with g/cm2), each inspection record 1 time before and after treatment; (4) blood, routine urinalysis and Liver and kidney function, electrocardiogram etc., respectively detects 1 time before medication and at the end of the course for the treatment of.
7, criterion of therapeutical effect is formulated according to the criterion of therapeutical effect of " new Chinese medicine guideline of clinical investigations ":
7.1, curative effect of disease evaluation criteria: effective: pain disappears completely, bone density inspection display bone density increases; Effective: pain is obviously alleviated, bone density inspection has no bone density and declines; Invalid: to compare after treatment with before treatment, each side is all without improvement.
7.2, therapeutic effect of syndrome criterion: clinical recovery: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=90%; Effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%; Effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%; Invalid: tcm clinical practice symptom, sign are all not improved, even increase the weight of, syndrome integral reduces less than 30%.
Note: computing formula (nimodipine method) is: [before (before treatment the rear integration of integration-treatment)+treatment integration] X 100%
8, statistical method: carry out date processing with SPSS16.0 statistical software.Measurement data adopts
two groups of Clinical efficacy comparisons adopt Ridit to analyze; Change before and after two groups of treatments adopts paired t-test.
9, result
9.1, two groups of curative effect of disease compare: after two groups of treatments, curative effect of disease compares, treatment group 50 example, effective 23 examples (46.0%), effective 24 examples (48.0%), invalid 3 examples (6.0%), total effective rate 94.0%.Matched group 50 example, effective 12 examples (24.0%), effective 21 examples (42.00%), invalid 17 examples (34.0%), total effective rate 66.0%.Treatment group total effective rate is better than matched group, and difference has statistical significance (P < 0.05).In table 1.
The two groups of curative effect of disease statistical (n, %) in front and back treated by table 1
9.2, two groups of syndrome integral compare: treat front two groups of syndrome integral and compare no significant difference (P < 0.05), have comparability.After treatment, two groups of patient's syndrome integral more all have clear improvement, difference has statistical significance (P < 0.05), and treatment group is obviously better than matched group, between two groups, comparing difference has statistical significance (P < 0.05).In table 2.
The two groups of therapeutic effect of syndrome statistical in front and back treated by table 2
Note: compare * P < 0.05 in group after treatment; Compare between group after treatment
#p < 0.05.
9.3, the change of the two groups of BMD in treatment front and back: treat front two groups of BMD and compare, no significant difference (P > 0.05), has comparability.After treatment, treatment group patient B MD all obviously raises, and has significant difference (P<0.05); Matched group comparatively treats front no significant difference (P > 0.05).The change for the treatment of group BMD is compared with matched group, and difference has statistical significance (P < 0.05).In table 3.
The comparison of BMD before and after table 3 liang group treatment
Note: compare * P < 0.05 between group after treatment.
9.4, two groups of blood calcium, phosphorus before and after treatment, estradiol level changes: treat front two groups of blood calcium, phosphorus compares no significant difference (P > 0.05), have comparability.After treatment, two groups of patient's blood calcium all raise, but no significant difference (P > 0.05); After treatment, two groups of patient's serium inorganic phosphorus all decrease, but no significant difference (P > 0.05); The change comparatively matched group there was no significant difference (P > 0.05) for the treatment of group blood calcium, phosphorus.
Treat front two groups of patient's estradiol level comparative result no significant differences (P > 0.05), there is comparability.Treatment group obviously raises (P < 0.05) before comparatively treating; Matched group comparatively treats front no significant difference (P > 0.05); After treatment, between group, the elevation amplitude of comparison therapy group is obviously greater than matched group, and difference has statistical significance (P < 0.05).In table 4.
Blood calcium, phosphorus before and after table 4 liang group treatment, estradiol level change is compared
Note: compare * P < 0.05 between group after treatment.
Before and after two groups of treatments, safety indexes blood, urine, stool routine and hepatic and renal function inspection are all in normal range.Two groups are showed no untoward reaction.
Visible: Chinese medicine preparation of the present invention treats postmenopausal osteoporosis at medicine, while improving symptom, improve bone density, improve bone metabolism, improve sex hormone level, treating both the principal and secondary aspects of a disease.
In a word, Chinese medicine preparation of the present invention, in treatment liver-kidney yin deficiency postmenopausal osteoporosis, compared with prior art has following advantage:
(1) compared with current chemotherapeutic agent, Chinese medicine preparation of the present invention, prescription is simple, for natural pure Chinese medicinal preparation, untoward reaction and side effect little, and Chinese medicine preparation effect of the present invention is comprehensive, and medication effect is better, significantly improve the compliance of postmenopausal osteoporotic patients, and improve the quality of life of patient.
(2) multi-medicament component is contained in Chinese medicine preparation of the present invention, action target spot is numerous, efficiently solves the morbidity root of liver-kidney yin deficiency postmenopausal osteoporosis, has both treated sick, again can prevention of diseae, it serves the effect for the treatment of both the principal and secondary aspects of a disease to the therapeutic effect of postmenopausal osteoporosis.
(3) the present invention is that inventor is on the basis of secret prescription handed down in the family from generation to generation, in conjunction with the summary of clinical experience for many years, obtain through repeatedly testing, therefore this medicine has unique curative effect to the postmenopausal osteoporosis that a variety of causes causes, this medical instrument has compatibility science, cure rate advantages of higher.
Detailed description of the invention
The detailed description of the invention of form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1
Prescription: Fructus Ligustri Lucidi 16 parts, Radix Rehmanniae Preparata 20 parts, Fructus Psoraleae 13 parts, Semen Cuscutae 13 parts, Folium Eucommiae 25 parts, the Radix Paeoniae Alba 17 parts, Folium Mahoniae 12 parts, Radix Achyranthis Bidentatae 10 parts.
Preparation method: each medicinal raw material taking recipe quantity, merge, decoct with water twice, first time adds water as 6 times amount of medical material weight, decocts 3.0 hours, second time adds water as 4 times amount of medical material weight, decoct 2 hours, collecting decoction, when being evaporated to 60 DEG C, relative density is 1.10, adding ethanol makes the volume ratio of alcohol content be 55%, stir, hold over night, filter, filtrate reduced in volume reclaims ethanol, be condensed into thick paste, add appropriate amount of auxiliary materials, mixing, drying, by field of Chinese medicines preparation routine encapsulation, preparation technology obtains capsule.
Embodiment 2
Prescription: Fructus Ligustri Lucidi 15 parts, Radix Rehmanniae Preparata 18 parts, Fructus Psoraleae 12 parts, Semen Cuscutae 11 parts, Folium Eucommiae 23 parts, the Radix Paeoniae Alba 15 parts, Folium Mahoniae 11 parts, Radix Achyranthis Bidentatae 9 parts.
Preparation method: each medicinal raw material taking recipe quantity, merge, decoct with water twice, first time adds water as 5 times amount of medical material weight, decocts 2.5 hours, second time adds water as 3 times amount of medical material weight, decoct 2.5 hours, collecting decoction, when being evaporated to 60 DEG C, relative density is 1.05, adding ethanol makes the volume ratio of alcohol content be 45%, stir, hold over night, filter, filtrate reduced in volume reclaims ethanol, be condensed into thick paste, add appropriate amount of auxiliary materials, mixing, drying, by field of Chinese medicines preparation routine encapsulation, preparation technology obtains capsule.
Embodiment 3
Prescription: Fructus Ligustri Lucidi 15-17 part, Radix Rehmanniae Preparata 18-21 part, Fructus Psoraleae 12-14 part, Semen Cuscutae 11-15 part, Folium Eucommiae 23-26 part, Radix Paeoniae Alba 15-18 part, Folium Mahoniae 11-13 part, Radix Achyranthis Bidentatae 9-11 part.
Preparation method: each medicinal raw material taking recipe quantity, merge, decoct with water twice, first time adds water as 7 times amount of medical material weight, decocts 3.0 hours, second time adds water as 5 times amount of medical material weight, decoct 2 hours, collecting decoction, when being evaporated to 60 DEG C, relative density is 1.20, adding ethanol makes the volume ratio of alcohol content be 50%, stir, hold over night, filter, filtrate reduced in volume reclaims ethanol, be condensed into thick paste, add appropriate amount of auxiliary materials, mixing, drying, by field of Chinese medicines preparation routine encapsulation, preparation technology obtains capsule.
Embodiment 4
Prescription: Fructus Ligustri Lucidi 15 parts, Radix Rehmanniae Preparata 20 parts, Fructus Psoraleae 12 parts, Semen Cuscutae 14 parts, Folium Eucommiae 24 parts, the Radix Paeoniae Alba 16 parts, Folium Mahoniae 12 parts, Radix Achyranthis Bidentatae 10 parts.
Preparation method: each medicinal raw material taking recipe quantity, merge, decoct with water twice, first time adds water as 6 times amount of medical material weight, decocts 2.5 hours, second time adds water as 3 times amount of medical material weight, decoct 2.5 hours, collecting decoction, when being evaporated to 60 DEG C, relative density is 1.15, adding ethanol makes the volume ratio of alcohol content be 55%, stir, hold over night, filter, filtrate reduced in volume reclaims ethanol, be condensed into thick paste, add appropriate amount of auxiliary materials, mixing, drying, by field of Chinese medicines preparation routine encapsulation, preparation technology obtains capsule.
Embodiment 5
Prescription: Fructus Ligustri Lucidi 13 parts, Radix Rehmanniae Preparata 16 parts, Fructus Psoraleae 11 parts, Semen Cuscutae 9 parts, Folium Eucommiae 21 parts, the Radix Paeoniae Alba 14 parts, Folium Mahoniae 9 parts, Radix Achyranthis Bidentatae 8 parts.
Preparation method: each medicinal raw material taking recipe quantity, merge, decoct with water twice, first time adds water as 5 times amount of medical material weight, decocts 2.5 hours, second time adds water as 3 times amount of medical material weight, decoct 2.5 hours, collecting decoction, when being evaporated to 60 DEG C, relative density is 1.15, adding ethanol makes the volume ratio of alcohol content be 45%, stir, hold over night, filter, filtrate reduced in volume reclaims ethanol, be condensed into thick paste, add appropriate amount of auxiliary materials, mixing, drying, by field of Chinese medicines preparation conventional tablet, preparation technology obtains tablet.
Embodiment 6
Prescription: Fructus Ligustri Lucidi 18 parts, Radix Rehmanniae Preparata 21 parts, Fructus Psoraleae 15 parts, Semen Cuscutae 15 parts, Folium Eucommiae 26 parts, the Radix Paeoniae Alba 19 parts, Folium Mahoniae 15 parts, Radix Achyranthis Bidentatae 13 parts.
Preparation method: each medicinal raw material taking recipe quantity, merge, decoct with water twice, first time adds water as 7 times amount of medical material weight, decocts 3.0 hours, second time adds water as-5 times amount of medical material weight, decoct 2.5 hours, collecting decoction, when being evaporated to 60 DEG C, relative density is 1.105, adding ethanol makes the volume ratio of alcohol content be 50%, stir, hold over night, filter, filtrate reduced in volume reclaims ethanol, be condensed into thick paste, add appropriate amount of auxiliary materials, mixing, drying, by field of Chinese medicines preparation conventional tablet, preparation technology obtains tablet.
Embodiment 7
Prescription: Fructus Ligustri Lucidi 15 parts, Radix Rehmanniae Preparata 16 parts, Fructus Psoraleae 15 parts, Semen Cuscutae 10 parts, Folium Eucommiae 21 parts, the Radix Paeoniae Alba 17 parts, Folium Mahoniae 13 parts, Radix Achyranthis Bidentatae 11 parts.
Preparation method: each medicinal raw material taking recipe quantity, merge, decoct with water twice, first time adds water as 6 times amount of medical material weight, decocts 3.0 hours, second time adds water as 4 times amount of medical material weight, decoct 2.5 hours, collecting decoction, when being evaporated to 60 DEG C, relative density is 1.05, adding ethanol makes the volume ratio of alcohol content be 45%, stir, hold over night, filter, filtrate reduced in volume reclaims ethanol, be condensed into thick paste, add appropriate amount of auxiliary materials, mixing, drying, by field of Chinese medicines preparation conventional tablet, preparation technology obtains tablet.
Embodiment 8
Prescription: Fructus Ligustri Lucidi 16 parts, Radix Rehmanniae Preparata 18 parts, Fructus Psoraleae 13 parts, Semen Cuscutae 15 parts, Folium Eucommiae 23 parts, the Radix Paeoniae Alba 15 parts, Folium Mahoniae 12 parts, Radix Achyranthis Bidentatae 10 parts.
Preparation method: each medicinal raw material taking recipe quantity, merge, decoct with water twice, first time adds water as 6 times amount of medical material weight, decocts 2.5 hours, second time adds water as 5 times amount of medical material weight, decoct 2.5 hours, collecting decoction, when being evaporated to 60 DEG C, relative density is 1.12, adding ethanol makes the volume ratio of alcohol content be 56%, stir, hold over night, filter, filtrate reduced in volume reclaims ethanol, be condensed into thick paste, add appropriate amount of auxiliary materials, mixing, drying, by the conventional granulates agent of field of Chinese medicines preparation, preparation technology obtains granule.
Embodiment 9
Prescription: Fructus Ligustri Lucidi 16 parts, Radix Rehmanniae Preparata 20 parts, Fructus Psoraleae 13 parts, Semen Cuscutae 13 parts, Folium Eucommiae 25 parts, the Radix Paeoniae Alba 17 parts, Folium Mahoniae 12 parts, Radix Achyranthis Bidentatae 10 parts.
Preparation method: each medicinal raw material taking recipe quantity, merge, decoct with water twice, first time adds water as 6 times amount of medical material weight, decocts 3.0 hours, second time adds water as 4 times amount of medical material weight, decoct 2.5 hours, collecting decoction, when being evaporated to 60 DEG C, relative density is 1.16, adding ethanol makes the volume ratio of alcohol content be 55%, stir, hold over night, filter, filtrate reduced in volume reclaims ethanol, be condensed into thick paste, add appropriate amount of auxiliary materials, mixing, drying, by the conventional granulates agent of field of Chinese medicines preparation, preparation technology obtains granule.
Embodiment 10
Prescription: Fructus Ligustri Lucidi 16 parts, Radix Rehmanniae Preparata 18 parts, Fructus Psoraleae 13 parts, Semen Cuscutae 12 parts, Folium Eucommiae 24 parts, the Radix Paeoniae Alba 16 parts, Folium Mahoniae 12 parts, Radix Achyranthis Bidentatae 11 parts.
Preparation method: each medicinal raw material taking recipe quantity, merge, decoct with water twice, first time adds water as 7 times amount of medical material weight, decocts 2.5 hours, second time adds water as 5 times amount of medical material weight, decoct .5 hour, collecting decoction, when being evaporated to 60 DEG C, relative density is 1.20, adding ethanol makes the volume ratio of alcohol content be 60%, stir, hold over night, filter, filtrate reduced in volume reclaims ethanol, be condensed into thick paste, add appropriate amount of auxiliary materials, mixing, drying, by field of Chinese medicines preparation, conventional pill preparation technology obtains pill.
Claims (7)
1. treat a Chinese medicine preparation for liver-kidney yin deficiency postmenopausal osteoporosis, it is characterized in that it is that medicinal raw material is made by Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, Fructus Psoraleae, Semen Cuscutae, Folium Eucommiae, the Radix Paeoniae Alba, Folium Mahoniae, Radix Achyranthis Bidentatae.
2. Chinese medicine preparation as claimed in claim 1, its feature is made at its medicinal raw material by following weight portion: Fructus Ligustri Lucidi 13-18 part, Radix Rehmanniae Preparata 16-21 part, Fructus Psoraleae 11-15 part, Semen Cuscutae 9-15 part, Folium Eucommiae 21-26 part, Radix Paeoniae Alba 14-19 part, Folium Mahoniae 9-15 part, Radix Achyranthis Bidentatae 8-13 part.
3. Chinese medicine preparation as claimed in claim 2, its feature is made at its medicinal raw material by following weight portion: Fructus Ligustri Lucidi 15-17 part, Radix Rehmanniae Preparata 18-21 part, Fructus Psoraleae 12-14 part, Semen Cuscutae 11-15 part, Folium Eucommiae 23-26 part, Radix Paeoniae Alba 15-18 part, Folium Mahoniae 11-13 part, Radix Achyranthis Bidentatae 9-11 part.
4. Chinese medicine preparation as claimed in claim 3, its feature is made at its medicinal raw material by following weight portion: Fructus Ligustri Lucidi 16 parts, Radix Rehmanniae Preparata 20 parts, Fructus Psoraleae 13 parts, Semen Cuscutae 13 parts, Folium Eucommiae 25 parts, the Radix Paeoniae Alba 17 parts, Folium Mahoniae 12 parts, Radix Achyranthis Bidentatae 10 parts.
5. the Chinese medicine preparation as described in as arbitrary in claim 1-4, its feature in the dosage form of described Chinese medicine preparation is: powder, pill, sublimed preparation, unguentum, granule, oral liquid, syrup, tablet, capsule etc.
6. Chinese medicine preparation as claimed in claim 5, its feature is preferably granule, tablet or capsule in the dosage form of described Chinese medicine preparation.
7. the Chinese medicine preparation as described in as arbitrary in claim 1-6, it is characterized in that its preparation method comprises the following steps: each medicinal raw material taking recipe quantity, merge, decoct with water twice, first time adds water as the 5-7 times amount of medical material weight, decoct 2.5-3.0 hour, second time adds water as the 3-5 times amount of medical material weight, decoct 2-2.5 hour, collecting decoction, when being evaporated to 60 DEG C, relative density is 1.05-1.20, adding ethanol makes the volume ratio of alcohol content be 45-60%, stir, hold over night, filter, filtrate reduced in volume reclaims ethanol, be condensed into thick paste, add appropriate amount of auxiliary materials, mixing, dry, prepare by field of Chinese medicines preparation common process.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105213684A (en) * | 2015-10-09 | 2016-01-06 | 王栩 | Be used for the treatment of osteoporotic Chinese medicine composition and preparation method thereof |
| CN105497262A (en) * | 2016-01-25 | 2016-04-20 | 青岛云天生物技术有限公司 | Medicine composition for treating liver-yin and kidney-yin deficiency type polycystic ovarian syndrome |
| CN107006681A (en) * | 2016-01-28 | 2017-08-04 | 柳泓善 | Animal feed composition containing Chinese medicinal material extract |
| CN114306497A (en) * | 2022-01-18 | 2022-04-12 | 云南省中医医院(云南中医药大学第一附属医院) | Traditional Chinese medicine composition for treating osteoporosis due to kidney deficiency and blood stasis, preparation and application |
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| CN104107306A (en) * | 2014-07-15 | 2014-10-22 | 林焱 | Traditional Chinese medicine for treating kidney essence deficiency syndrome type postmenopausal osteoporosis |
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| CN104107306A (en) * | 2014-07-15 | 2014-10-22 | 林焱 | Traditional Chinese medicine for treating kidney essence deficiency syndrome type postmenopausal osteoporosis |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213684A (en) * | 2015-10-09 | 2016-01-06 | 王栩 | Be used for the treatment of osteoporotic Chinese medicine composition and preparation method thereof |
| CN105497262A (en) * | 2016-01-25 | 2016-04-20 | 青岛云天生物技术有限公司 | Medicine composition for treating liver-yin and kidney-yin deficiency type polycystic ovarian syndrome |
| CN107006681A (en) * | 2016-01-28 | 2017-08-04 | 柳泓善 | Animal feed composition containing Chinese medicinal material extract |
| CN114306497A (en) * | 2022-01-18 | 2022-04-12 | 云南省中医医院(云南中医药大学第一附属医院) | Traditional Chinese medicine composition for treating osteoporosis due to kidney deficiency and blood stasis, preparation and application |
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