CN107569667A - A kind of Dihuang Wan and preparation method - Google Patents
A kind of Dihuang Wan and preparation method Download PDFInfo
- Publication number
- CN107569667A CN107569667A CN201710884752.2A CN201710884752A CN107569667A CN 107569667 A CN107569667 A CN 107569667A CN 201710884752 A CN201710884752 A CN 201710884752A CN 107569667 A CN107569667 A CN 107569667A
- Authority
- CN
- China
- Prior art keywords
- parts
- ball
- powder
- dihuang wan
- pill
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a kind of Dihuang Wan and preparation method, is made up of following parts by weight components：102 126 parts of Dihuang Wan medicinal powder, 100 127 parts of Dihuang Wan medicinal extract, 12 45 parts of five tastes tonifying Qi powder, 0.1 0.2 parts of flowers and fruits vinegar, 3.7 27.5 parts of starch, 1.11 3.56 parts of Icing Sugar, 4.12 4.3 parts of talcum powder, 0.1 0.2 parts of insect wax, 1.5 7 parts of 95% ethanol solution；Mixed by bulk drug milling and after extracting, progress microwave drying is degerming after refining medicine, pill, drawing light and once sieving ball, then carries out secondary sieve ball, and last total mixed polishing produces Dihuang Wan.Obtained Dihuang Wan is brown to the condensed pill of brownish black, and gas is micro-, sweet and sour, and slightly flowers and fruits are fragrant；Leaching the time substantially reduces, most fast up to 50min, increases the bioavilability of medicine, extends and accelerate the onset time of medicine；Major function：Affection by cold after delivery, insufficiency of vital energy and blood.For postpartum dizziness caused by affection by cold after delivery, head is heavy or pain, waist, knee, ankle, wrist etc. is numb, sore, emits cold sweat breathes hard, nervous or palpitaition.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Dihuang Wan and preparation method.
Background technology
Affection by cold after delivery, name of disease.Refer to illness caused by postpartum being invaded by exogenous pathogen,invasion of exogenous pathogen.The lighter has a headache aversion to cold, when see heating, under the heart
It is vexed, retch sweating etc..Severe one heating flushing, dyspnea and headache, very then lockjaws, opisthotonos, senseless etc..
In postpartum, form the joint of pelvis and all of body are partially in loose condition (of surface).Because various bodies change and divided
The symptom such as physical loss, bleeding caused by childbirth, puerpera's 6 time-of-weeks of needs could recover normal condition, this period quilt
Referred to as puerperium.If it is improper to be nursed one's health during this, the torment of cold after delivery will be born all one's life.Advanced age childbirth, difficult labour, caesarean birth,
The puerpera repeatedly to miscarry is more susceptible to suffer from cold after delivery.Typically there is symptom after 8 weeks postpartum, if let go unchecked, it is possible to continue
Even several years several months, thus it is certain it is noted that.
《Yifangleiju》235 are rolled up to draw《All (Chuo nonyls page) teaches Ji quick-acting prescription opinion》Described in take radix rehmanniae recen (to grind and take juice, stay
Dregs) 2 jins, 2 jin of ginger (grind and take juice, stay dregs), 4 liang of cattail pollen, 4 liang of Radix Angelicae Sinensis, in silverware, take glutinous rehmannia juice to fry ginger with slow fire
Dregs, glutinous rehmannia dregs is fried with ginger juice, each order is dry, and four tastes are same dry, are smalls, it is ball that vinegar, which boils batter, as pellet is big.1 ball is often taken, before food
With under Radix Angelicae Sinensis alcoholization.Postpartum abdominal pain is cured mainly, soon black flower, or insane appearance induced likely by seeing ghosts of going mad, or retention of afterbirth, in silence, ambition is swollen for aphonia
Full, indigestion, dry polydipsia, fevers and chills alternate, intraoral raw sore, abscess of throat is alarmed and panicky in the heart to throb with fear, and night must not sleep, affection by cold after delivery, angle
Bend anti-sheet, flushing, mandibular joint is urgent, or metrorrhagia such as globefish liver, and navel abdomen (Epileptic Yu) pain, agitation is throbbed with fear Hu, and four limbs turgor, and fertilization are unstable,
Lip nail green grass or young crops is black.
Though the Dihuang Wan of ancient method treatment affection by cold after delivery on the books, be made into the prior art pill and few, and
And it is slow to work, Chinese medicine taste is dense, and material loss is serious, and stability is poor, should not preserve for a long time.
The content of the invention
It is an object of the invention to provide a kind of Dihuang Wan and preparation method, obtained Dihuang Wan is brown to brownish black
Condensed pill, gas is micro-, sweet and sour, and slightly flowers and fruits are fragrant, leaches the time and substantially reduces, drug effect is fast, and pill particle diameter and weight are equal
Even, the supplementary material proportion of goods damageds are 0, greatly reduce cost.
The purpose of the present invention can be achieved through the following technical solutions：
A kind of Dihuang Wan, it is made up of following parts by weight components：Dihuang Wan medicinal powder 102-126 parts, Dihuang Wan medicinal extract 100-
127 parts, five tastes tonifying Qi powder 12-45 parts, flowers and fruits vinegar 0.1-0.2 parts, starch 3.7-27.5 parts, Icing Sugar 1.11-3.56 parts, talcum powder
4.12-4.3 parts, insect wax 0.1-0.2 parts, 95% ethanol solution 1.5-7 parts.
Described Dihuang Wan medicinal powder be by 20.87 parts of moutan bark, 25.2 parts of Fructus Corni, 31.5 parts of Poria cocos, 10.5 parts of Radix Angelicae Sinensis,
42 parts of calcined CONCHA HALIOTIDIS, 10.5 parts of cattail pollen crush the fine powder formed；
Described Dihuang Wan medicinal extract by 96 parts of prepared rhizome of rehmannia, 21 parts of ginger, 31.5 parts of the fruit of Chinese wolfberry, 31 parts of the wind-weed, 31 parts of golden cypress,
It is made after 31.5 parts of 31.5 parts of the root of herbaceous peony, 31.5 parts of puncture vine, chrysanthemum extraction thick paste mixing.
Described five tastes tonifying Qi powder is by 25 parts of polished rice, 12.7 parts of spinach of dehydration, 25 parts of soy meal, 8.6 parts of dry longan, black sesame
It is milled and obtains after 11 parts of drying of fiber crops；
Described flowers and fruits vinegar is in persimmon vinegar, Hawthorn Vinegar, jujube vinegar, mulberry fruit vinegar, Rose vinegar, robiniae,flos vinegar, jelly vinegar
Any one.
Described Icing Sugar brown sugar powder, the mixed powder of royal jelly freeze-dried powder, brown sugar powder, the weight ratio of royal jelly freeze-dried powder are 5：
1。
A kind of preparation method of Dihuang Wan, specifically includes following steps：
(1) pre-prepared process
A, pulverizing process：
A1, Dihuang Wan medicinal powder preparation：Weigh 20.87 parts of moutan bark, 25.2 parts of Fructus Corni, 31.5 parts of Poria cocos, Radix Angelicae Sinensis
10.5 parts, 10.5 parts of 42 parts of calcined CONCHA HALIOTIDIS, cattail pollen addition pulverizers be ground into fine powder, be stored in fine powder storehouse；
A2, the five tastes tonifying Qi powder preparation：Weigh 25 parts of polished rice, 12.7 parts of spinach of dehydration, 25 parts of soy meal, dry longan 8.6
Pulverizer is added after 11 parts of part, Semen sesami nigrum drying and is ground into fine powder, is stored in fine powder storehouse；
A3, weigh in mass ratio brown sugar powder, royal jelly freeze-dried powder it is well mixed after sieve, whole operation is at low ambient temperatures
Carry out；
B, the extraction of Dihuang Wan medicinal extract：Weigh 96 parts of prepared rhizome of rehmannia, 21 parts of ginger, 31.5 parts of the fruit of Chinese wolfberry, 31 parts of the wind-weed, golden cypress
31 parts, 31.5 parts of the root of herbaceous peony, 31.5 parts of puncture vine, 31.5 parts of chrysanthemum be added to the water decoction, collecting decoction, filtering, filtrate is condensed into thick
Cream, it is stored in standby in freezer；
(2) softwood is refined
Weigh Dihuang Wan medicinal powder, starch, Icing Sugar to be placed in trough type mixing machine, start is dry-mixed, then is slowly added into five tastes tonifying Qi
Powder, Dihuang Wan medicinal extract, flowers and fruits vinegar and appropriate purified water, wet mixing, obtain softwood semi-finished product, and softwood semi-finished product then are sent into bilayer
Medicine refining machine refines to obtain softwood；
(3) pill
A, test-run a machine：It will be operated in softwood input high efficient full automatic pellet processing machine after refining, regulation ethanol goes out liquid, prevents
Viscous knife, then runs formal pill；
B, commencement of commercial operation：Weigh Dihuang Wan medicinal powder dusting and connect ball, prevent adhesion, produce wet ball；In pelletizing process, medicine is extracted
Ball is weighed record, and whether the whether uniform rounding of random observation pill, ball face are smooth；Sampling pill used not can return to, and receive
Collection sampling pill is waited to reuse；
C, light is drawn：The wet ball made is sent in Dumpage type polishing machine, adds ethanol solution, and light is drawn using Dihuang Wan medicinal powder
It is moulding, uniformly taken the dish out of the pot to outer surface rounding；
D, ball is once sieved：Wet ball after drawing light is sent into rotary screen to be screened first, first qualified ball is obtained, collects
Excessive or too small pill is waited to reuse；
E, microwave drying, secondary sieve ball：First qualified ball after sieve ball is sent into tunnel type microwave drying sterilizer to carry out
Dry sterilization produces dry ball；
Then dry ball carries out postsearch screening by rotary screen, obtains secondary qualified ball；Secondary qualified ball is passed through into vacuum again
Feeder is sent to spiral pellet selecting machine and screened, and the pill of spiral pellet selecting machine outlet is qualified ball, by the qualified ball of collection
It is fitted into the Plastic Drum of cleaning；
F, the preparation of Dihuang Wan fine powder：Excessive or too small pill, sampling pill and the spiral that collection cylinder filters out
A ball for the unqualified ball outlet of ball machine is selected, is pulverized and sieved by turbine grinder, obtains Dihuang Wan fine powder；
(4) it is total mixed：Qualified ball after sieve ball is sent in two-dimensional mixing machine by vacuum feeder and mixed, is mixed
It is fitted into afterwards in the Plastic Drum of cleaning；
(5) polishing：
A, medicinal extract is dilute matches somebody with somebody：Add purified water in Dihuang Wan medicinal extract and stir.
B, polishing：Pill after total mix is poured into water chestnut type coating machine, seed-coating machine is opened, by the medicinal extract of dilution, glutinous rehmannia
Ball fine powder, talcum powder are sequentially added in water chestnut type coating machine, are then added insect wax in water chestnut type coating machine, are opened blower fan and are blown
Wind, taken the dish out of the pot with vacuum charger, produce Dihuang Wan.
Condition of storage described in step (1) a1, a2 is：10 DEG C of 20 DEG C of ＜ storage temperatures ＜, relative humidity：40%~
60%；Oven temperature described in step (1) a2 is 45-60 DEG C；
Low temperature environment described in step (1) a3 is：5 DEG C of 15 DEG C of ＜ storage temperatures ＜, relative humidity：30%~45%, institute
The sieve aperture stated is 100 mesh.
Number is added water to cook as three times, each decocting time is 2h described in step (1) b；Described Dihuang Wan medicinal extract
Storage temperature is 2~10 DEG C.
The dry-mixed time described in step (2) is 10 minutes；The appropriate purified water of described addition is determined with softwood soft durometer
Surely water consumption is purified, the amount for adding purified water is the 19.5%-21.1% of starch addition；The described wet mixing time is 3-5 points
Clock.
The shaping bore dia of high efficient full automatic pellet processing machine described in step (3) a is 5.9-6.5mm, tool diameter 6.3-
6.7mm, defeated bar FREQUENCY CONTROL are 25-35Hz.
The condition of the formal pill of operation described in step (3) a is that can be transported when every 10 balls are focused in 1.80~2.00g hairs
OK；
The amount for weighing Dihuang Wan medicinal powder described in step (3) b is the 1%-3% of total glutinous rehmannia pill powder；Described pill mistake
Cheng Zhong, 10 balls were taken to weigh from every high efficient full automatic pellet processing machine every 20 minutes；
Ethanol solution described in step (3) c is 95% ethanol and the mixed liquor of purified water, 95% ethanol and purified water weight
Than for 3.75:1；The described amount using Dihuang Wan medicinal powder is the 1%-3% of total glutinous rehmannia pill powder；10- between during described drawing light
15 minutes；
Rotary screen mesh size described in step (3) d is 5.8~6.5mm；
The pill weight variation control range of described first qualified ball is no more than ± 7.0%；
50~60 DEG C of step (3) e settings dry materials temperature, the control of discharging drying temperature is at 50~60 DEG C, transmission speed
For 1.0~2.0m/min, thickness control is controlled 3.5~5.5% in 0.6~1.4cm, dry ball moisture；
The rotary screen mesh size of postsearch screening described in step (3) e is 6.0~6.7mm；Described secondary qualified ball
Pill weight variation control range is no more than ± 7.0%；Described transmission speed is 1.5-2.5m/min；Described secondary sieve ball yield
Up to 99.6%；
Mesh size described in step (3) f is 100 mesh, crushes high income up to 97%.
Two-dimensional mixing machine mixing revolution described in step (4) is 6.8 revs/min, and incorporation time is 30 minutes, the thing of mixing
Material balanced ratio is up to 100.0%.
The amount of Dihuang Wan medicinal extract described in step (5) a is the 3%-8.5% of total Dihuang Wan medicinal extract；Add the amount of purified water
For the 9.1%-16% of the medicinal extract total amount of dilution；Described mixing time is 4-6 minutes.
Step (5) b add insect wax precondition be when pellet surface rounding is uniform, color and luster is consistent, it is smooth when
Add；Described blow-time is 40-60 minutes.
Described Dihuang Wan is condensed pill of the brown to brownish black；Gas is micro-, sweet and sour, and slightly flowers and fruits are fragrant；Average 10 balls
Weight is 1.60~1.80g, moisture≤7.5%；It is most fast up to 50min to leach the time；Microorganism detection result is：Aerobic bacteria is total
Number≤24000cfu/g, mould, saccharomycete sum≤80cfu/g, bile tolerance gram-negative bacteria ＜ 100cfu/g, EHEC
Do not detect, detection of Salmonella does not detect.
Beneficial effects of the present invention：
1st, Dihuang Wan of the present invention is condensed pill of the brown to brownish black；Gas is micro-, sweet and sour, and slightly flowers and fruits are fragrant；Every 8 ball phase
Substantially reduced when in crude drug 3g, leaching the time, it is most fast up to 50min, increase the bioavilability of medicine, extend and accelerate
The onset time of medicine；Microorganism detection result is：Aerobic bacteria sum≤24000cfu/g, mould, saccharomycete sum≤
80cfu/g, bile tolerance gram-negative bacteria ＜ 100cfu/g, EHEC do not detect, and detection of Salmonella does not detect.Major function：Production
Apoplexy, insufficiency of vital energy and blood afterwards.For postpartum dizziness, head to be sunk caused by affection by cold after delivery or pain, waist, knee, ankle, wrist etc. is sent out
It is numb, sore, emit cold sweat breathes hard, nervous or palpitaition.
2nd, the five tastes tonifying Qi powder of addition has good the effect of filling blood, can ancillary drug absorption, increase drug effect, have
Help patient's early recovery of affection by cold after delivery.
3rd, the flowers and fruits vinegar of addition is according to " it is ball that vinegar, which boils batter, " in ancient prescription, after scientific matching, contributes to the release of medicine
Absorb, enhance the anti-oxidant of Dihuang Wan.
4th, the brown sugar powder and royal jelly freeze-dried powder of addition, not only improves the taste of Dihuang Wan, is taken suitable for patient, also has
The effect of health care, contribute to the recovery of patient.
5th, ball is sieved by rotary screen twice in producing, and ball is selected through spiral pellet selecting machine, secondary sieve ball high income up to 99.6%,
In the range of 6.0~6.7mm, average 10 ball weight are produced obtained particle diameter in the range of 1.60~1.80g by strict control
The pill form and weight in each stage, obtained pill surface rounding is uniform, color and luster is consistent, smooth and particle diameter and weight more
Uniformly.
6th, will be reused after pill excessive in production or too small, underproof and sampling pouch, as polishing material
Material uses, and the supplementary material proportion of goods damageds are 0, crushes high income up to 97%, greatly reduces cost.
7th, the production technology of the Dihuang Wan rationally, stably, is adapted to industrial production, obtained Dihuang Wan stability is good, effectively
Phase is 36 months.
Embodiment
The technical scheme in the embodiment of the present invention will be clearly and completely described below, it is clear that described implementation
Example only part of the embodiment of the present invention, rather than whole embodiments.It is common based on the embodiment in the present invention, this area
All other embodiment that technical staff is obtained under the premise of creative work is not made, belong to the model that the present invention protects
Enclose.
Embodiment 1
Formula：Dihuang Wan medicinal powder 104.9kg, Dihuang Wan medicinal extract 105.5kg, five tastes tonifying Qi powder 12kg, flowers and fruits vinegar 0.1kg,
Starch 6.09kg, Icing Sugar 1.11kg, talcum powder 4.26kg, insect wax 0.122kg, 95% ethanol solution 1.5kg.
(1) pre-prepared process
A, pulverizing process：
A1, Dihuang Wan medicinal powder preparation：Weigh moutan bark 20.87kg, Fructus Corni 25.2kg, Poria cocos 31.5kg, Radix Angelicae Sinensis
10.5kg, calcined CONCHA HALIOTIDIS 42kg, cattail pollen 10.5kg add pulverizer and are ground into fine powder, are stored in fine powder storehouse, storage temperature is
19.5 DEG C, relative humidity：60%；
A2, the five tastes tonifying Qi powder preparation：Weigh polished rice 25kg, dehydration spinach 12.7kg, soy meal 25kg, dry longan
8.6kg, Semen sesami nigrum 11kg add pulverizer after being dried in the baking oven that temperature is 45 DEG C and are ground into fine powder, are stored in fine powder storehouse
In, storage temperature is 19.5 DEG C, relative humidity：60%；
A3, weigh 0.925kg brown sugar powder, 0.185kg royal jelly freeze-dried powders it is well mixed after cross the sieve that aperture is 100,
Whole operation is 5 DEG C in temperature, and relative humidity is carried out in the environment of being 30%；
B, the extraction of Dihuang Wan medicinal extract：Weigh prepared rhizome of rehmannia 96kg, ginger 21kg, fruit of Chinese wolfberry 31.5kg, wind-weed 31kg, golden cypress
31kg, root of herbaceous peony 31.5kg, puncture vine 31.5kg, chrysanthemum 31.5kg are added to the water decoction three times, each 2h, collecting decoction, filter, filter
Liquid is condensed into thick paste, obtains Dihuang Wan medicinal extract, be stored in it is standby in freezer, temperature be 10 DEG C；
C, ethanol solution is prepared：Weigh 95% ethanol 1.5kg and add purified water 0.4kg, stir and produce；
(2) softwood is refined
Weigh 100.4kg Dihuang Wans medicinal powder, 6.09kg starch, 1.11kg Icing Sugar to be placed in trough type mixing machine, start is dry-mixed
After 10 minutes, then 12kg five tastes tonifying Qi powder, 99.5kg Dihuang Wans medicinal extract, 0.1kg jujube vinegars and 1.19kg purified waters are slowly added into,
Mixing 3 minutes, obtains softwood semi-finished product, softwood semi-finished product then are sent into double-deck medicine refining machine refines to obtain softwood；
(3) pill
A, test-run a machine：It will be operated in softwood input high efficient full automatic pellet processing machine after refining, select a diameter of 6.1mm's
Shaping hole and a diameter of 6.3mm cutter, defeated bar FREQUENCY CONTROL are 35Hz, and regulation ethanol goes out liquid, viscous knife are prevented, when every 10 balls
1.80~2.00g is focused on, ball meets the requirements again, formal pill operation；
B, commencement of commercial operation：Weigh Dihuang Wan medicinal powder 2.5kg dustings and connect ball, prevent adhesion, produce wet ball.In pelletizing process,
Took 10 balls to weigh from every high efficient full automatic pellet processing machine every 20 minutes, survey ball tuple according to inserting in record form, see at random
The whether uniform rounding of pill is examined, whether ball face is smooth；Sampling pill used not can return to, and collects extraction pill and waits to repeat profit
With；
C, light is drawn：The wet ball made is sent in Dumpage type polishing machine, is added ethanol solution 1.9kg, is used 2.0kg glutinous rehmannia
Pill powder draw light it is moulding, draw light when between be 10 minutes, uniformly taken the dish out of the pot to outer surface rounding；
D, ball is once sieved：The wet ball after light will be drawn to be sent to rotary screen and screened first, mesh size for 5.8~
6.5mm, the pill for taking 5.8~6.5mm of particle diameter are first qualified ball, and pill weight variation control range is no more than ± 7.0%, collected
Big or too small pill is waited to reuse；
E, microwave drying, secondary sieve ball：First qualified ball after sieve ball is sent into tunnel type microwave drying sterilizer to carry out
Dry sterilization produces dry ball, sets dry materials temperature as 60 DEG C, and discharging drying temperature is 60 DEG C, transmission speed 1.5m/
Min, for thickness control in 0.6cm, dry ball moisture is 3.5%；
Then dry ball carries out postsearch screening by rotary screen, and mesh size is：6.0~6.7mm, take particle diameter for 6.0~
6.7mm pill is secondary qualified ball, and pill weight variation control range is no more than ± 7.0%；Secondary qualified ball is passed through into vacuum again
Feeder is sent to spiral pellet selecting machine and screened, and the pill of spiral pellet selecting machine outlet is qualified ball, by the qualified ball of collection
It is fitted into the Plastic Drum of cleaning；Secondary sieve ball yield is 99.6%；
F, the preparation of Dihuang Wan fine powder：Excessive or too small pill, sampling pill and the spiral that collection cylinder filters out
A ball for the unqualified ball outlet of ball machine is selected, is pulverized and sieved by turbine grinder, screen cloth is 100 mesh, is ground into Dihuang Wan fine powder；
It is 97.0% to crush yield；
(4) it is total mixed：Qualified ball after sieve ball is sent in two-dimensional mixing machine by vacuum feeder and mixed, is mixed
6.8 revs/min of revolution, incorporation time 30 minutes, it is fitted into the Plastic Drum of cleaning；Material balance rate is 100.0%；
(5) polishing：
A, medicinal extract is dilute matches somebody with somebody：Stirred 1kg purified waters are added in Dihuang Wan medicinal extract 6kg 5 minutes, make solution uniformity；
B, polishing：Pill after total mix is poured into water chestnut type coating machine, seed-coating machine is opened, by the medicinal extract of dilution, glutinous rehmannia
Ball fine powder, 4.26kg talcum powder are sequentially added in water chestnut type coating machine, when pellet surface rounding is uniform, color and luster is consistent, it is smooth when
Insect wax 0.122kg is added in water chestnut type coating machine, blower fan is opened and dries 60 minutes, makes pill bright, color and luster is consistent, average
10 ball weights are 1.60g, moisture 7.5%, are taken the dish out of the pot with vacuum charger, produce Dihuang Wan, are condensed pill of the brown to brownish black；
Gas is micro-, sweet and sour, and slightly flowers and fruits are fragrant；It is 50min to leach the time；Microorganism detection result is：Aerobic bacteria sum is
22300cfu/g, mould, saccharomycete sum are 55cfu/g, and bile tolerance gram-negative bacteria should be 46cfu/g, and EHEC is not
Detection, detection of Salmonella do not detect.
Embodiment 2
Formula：Dihuang Wan medicinal powder 120kg, Dihuang Wan medicinal extract 118.8kg, five tastes tonifying Qi powder 45kg, flowers and fruits vinegar 0.2kg, shallow lake
Powder 20.16kg, Icing Sugar 3.56kg, talcum powder 4.2kg, insect wax 0.12kg, 95% ethanol solution 7kg.
(1) pre-prepared process
A, pulverizing process：
A1, Dihuang Wan medicinal powder preparation：Weigh moutan bark 20.87kg, Fructus Corni 25.2kg, Poria cocos 31.5kg, Radix Angelicae Sinensis
10.5kg, calcined CONCHA HALIOTIDIS 42kg, cattail pollen 10.5kg add pulverizer and are ground into fine powder, are stored in fine powder storehouse, storage temperature is
10.2 DEG C, relative humidity：40%；
A2, the five tastes tonifying Qi powder preparation：Weigh polished rice 25kg, dehydration spinach 12.7kg, soy meal 25kg, dry longan
8.6kg, Semen sesami nigrum 11kg add pulverizer after being dried in the baking oven that temperature is 60 DEG C and are ground into fine powder, are stored in fine powder storehouse
In, storage temperature is 10.2 DEG C, relative humidity：40%；
A3, weigh 2.97kg brown sugar powder, 0.59kg royal jelly freeze-dried powders it is well mixed after cross the sieve that aperture is 100, it is whole
Individual operation is 15 DEG C in temperature, and relative humidity is carried out in the environment of being 45%；
B, the extraction of Dihuang Wan medicinal extract：Weigh prepared rhizome of rehmannia 96kg, ginger 21kg, fruit of Chinese wolfberry 31.5kg, wind-weed 31kg, golden cypress
31kg, root of herbaceous peony 31.5kg, puncture vine 31.5kg, chrysanthemum 31.5kg are added to the water decoction three times, each 2h, collecting decoction, filter, filter
Liquid is condensed into thick paste, obtains Dihuang Wan medicinal extract, be stored in it is standby in freezer, temperature be 2 DEG C；
C, ethanol solution is prepared：Weigh 95% ethanol 7kg and add purified water 1.9kg, stir and produce；
(2) softwood is refined
Weigh 116kg Dihuang Wans medicinal powder, 20.16kg starch, 3.56kg Icing Sugar to be placed in trough type mixing machine, start dry-mixed 10
After minute, then 45kg five tastes tonifying Qi powder, 112.8kg Dihuang Wans medicinal extract, 0.2kg mulberry fruit vinegars and 4.25kg purified waters are slowly added into,
Mixing 5 minutes, obtains softwood semi-finished product, softwood semi-finished product then are sent into double-deck medicine refining machine refines to obtain softwood；
(3) pill
A, test-run a machine：It will be operated in softwood input high efficient full automatic pellet processing machine after refining, select a diameter of 6.5mm's
Shaping hole and a diameter of 6.7mm cutter, defeated bar FREQUENCY CONTROL are 25Hz, and regulation ethanol goes out liquid, viscous knife are prevented, when every 10 balls
1.80~2.00g is focused on, ball meets the requirements again, formal pill operation；
B, commencement of commercial operation：Weigh Dihuang Wan medicinal powder 3kg dustings and connect ball, prevent adhesion, produce wet ball.In pelletizing process, often
Took 10 balls to weigh from every high efficient full automatic pellet processing machine every 20 minutes, survey ball tuple evidence and insert in record form, random observation
Whether the whether uniform rounding of pill, ball face are smooth；Sampling pill used not can return to, and collects extraction pill and waits to reuse；
C, light is drawn：The wet ball made is sent in Dumpage type polishing machine, is added ethanol solution 8.9kg, is used 1kg Dihuang Wans
Medicinal powder draw light it is moulding, draw light when between be 10 minutes, uniformly taken the dish out of the pot to outer surface rounding；
D, ball is once sieved：The wet ball after light will be drawn to be sent to rotary screen and screened first, mesh size for 5.8~
6.5mm, the pill for taking 5.8~6.5mm of particle diameter are first qualified ball, and pill weight variation control range is no more than ± 7.0%, collected
Big or too small pill is waited to reuse；
E, microwave drying, secondary sieve ball：First qualified ball after sieve ball is sent into tunnel type microwave drying sterilizer to carry out
Dry sterilization produces dry ball, sets dry materials temperature as 50 DEG C, and discharging drying temperature is 50 DEG C, transmission speed 2.5m/
Min, for thickness control in 1.4cm, dry ball moisture is 5.5%；
Then dry ball carries out postsearch screening by rotary screen, and mesh size is：6.0~6.7mm, take particle diameter for 6.0~
6.7mm pill is secondary qualified ball, and pill weight variation control range is no more than ± 7.0%；Secondary qualified ball is passed through into vacuum again
Feeder is sent to spiral pellet selecting machine and screened, and the pill of spiral pellet selecting machine outlet is qualified ball, by the qualified ball of collection
It is fitted into the Plastic Drum of cleaning；Secondary sieve ball yield is 98%；
F, the preparation of Dihuang Wan fine powder：Excessive or too small pill, sampling pill and the spiral that collection cylinder filters out
A ball for the unqualified ball outlet of ball machine is selected, is pulverized and sieved by turbine grinder, screen cloth is 100 mesh, is ground into Dihuang Wan fine powder；
It is 93.0% to crush yield；
(4) it is total mixed：Qualified ball after sieve ball is sent in two-dimensional mixing machine by vacuum feeder and mixed, is mixed
6.8 revs/min of revolution, incorporation time 30 minutes, it is fitted into the Plastic Drum of cleaning；Material balance rate is 99.3%；
(5) polishing：
A, medicinal extract is dilute matches somebody with somebody：Stirred 0.5kg purified waters are added in Dihuang Wan medicinal extract 6kg 5 minutes, make solution uniformity.
B, polishing：Pill after total mix is poured into water chestnut type coating machine, seed-coating machine is opened, by the medicinal extract of dilution, glutinous rehmannia
Ball fine powder, 4.2kg talcum powder are sequentially added in water chestnut type coating machine, when pellet surface rounding is uniform, color and luster is consistent, it is smooth when will
Insect wax 0.12kg is added in water chestnut type coating machine, is opened blower fan and is dried 40 minutes, makes pill bright, and color and luster is consistent, and average 10
Ball weight is 1.80g, moisture 3.2%, is taken the dish out of the pot with vacuum charger, produces Dihuang Wan, is condensed pill of the brown to brownish black；Gas
Micro-, sweet and sour, slightly flowers and fruits are fragrant；It is 80min to leach the time；Microorganism detection result is：Aerobic bacteria sum is 21520cfu/
G, mould, saccharomycete sum are 71cfu/g, and bile tolerance gram-negative bacteria should be 82cfu/g, and EHEC does not detect, sramana
Bacterium does not detect.
Embodiment 3
Formula：Dihuang Wan medicinal powder 126kg, Dihuang Wan medicinal extract 120.9kg, five tastes tonifying Qi powder 31kg, flowers and fruits vinegar 0.13kg, shallow lake
Powder 3.75kg, Icing Sugar 2.48kg, talcum powder 4.3kg, insect wax 0.12kg, 95% ethanol solution 2.2kg.
(1) pre-prepared process
A, pulverizing process：
A1, Dihuang Wan medicinal powder preparation：Weigh moutan bark 20.87kg, Fructus Corni 25.2kg, Poria cocos 31.5kg, Radix Angelicae Sinensis
10.5kg, calcined CONCHA HALIOTIDIS 42kg, cattail pollen 10.5kg add pulverizer and are ground into fine powder, are stored in fine powder storehouse, storage temperature is
14.5 DEG C, relative humidity：52%；
A2, the five tastes tonifying Qi powder preparation：Weigh polished rice 25kg, dehydration spinach 12.7kg, soy meal 25kg, dry longan
8.6kg, Semen sesami nigrum 11kg add pulverizer after being dried in the baking oven that temperature is 55 DEG C and are ground into fine powder, are stored in fine powder storehouse
In, storage temperature is 14.5 DEG C, relative humidity：52%；
A3, weigh 2.07kg brown sugar powder, 0.41kg royal jelly freeze-dried powders it is well mixed after cross the sieve that aperture is 100, it is whole
Individual operation is 10 DEG C in temperature, and relative humidity is carried out in the environment of being 38%；
B, the extraction of Dihuang Wan medicinal extract：Weigh prepared rhizome of rehmannia 96kg, ginger 21kg, fruit of Chinese wolfberry 31.5kg, wind-weed 31kg, golden cypress
31kg, root of herbaceous peony 31.5kg, puncture vine 31.5kg, chrysanthemum 31.5kg are added to the water decoction three times, each 2h, collecting decoction, filter, filter
Liquid is condensed into thick paste, obtains Dihuang Wan medicinal extract, be stored in it is standby in freezer, temperature be 6 DEG C；
C, ethanol solution is prepared：Weigh 95% ethanol 2.2kg and add purified water 0.59kg, stir and produce；
(2) softwood is refined
Weigh 122.5kg Dihuang Wans medicinal powder, 3.75kg starch, 2.48kg Icing Sugar to be placed in trough type mixing machine, start is dry-mixed
After 10 minutes, then it is slowly added into 31kg five tastes tonifying Qi powder, 111.9kg Dihuang Wans medicinal extract, 0.13kg jelly vinegar and 0.75kg purifying
Water, mix 5 minutes, obtain softwood semi-finished product, softwood semi-finished product then are sent into double-deck medicine refining machine refines to obtain softwood；
(3) pill
A, test-run a machine：It will be operated in softwood input high efficient full automatic pellet processing machine after refining, select a diameter of 5.9mm's
Shaping hole and a diameter of 6.5mm cutter, defeated bar FREQUENCY CONTROL are 28Hz, and regulation ethanol goes out liquid, viscous knife are prevented, when every 10 balls
1.80~2.00g is focused on, ball meets the requirements again, formal pill operation；
B, commencement of commercial operation：Weigh Dihuang Wan medicinal powder 2kg dustings and connect ball, prevent adhesion, produce wet ball.In pelletizing process, often
Took 10 balls to weigh from every high efficient full automatic pellet processing machine every 20 minutes, survey ball tuple evidence and insert in record form, random observation
Whether the whether uniform rounding of pill, ball face are smooth；Sampling pill used not can return to, and collects extraction pill and waits to reuse；
C, light is drawn：The wet ball made is sent in Dumpage type polishing machine, adds ethanol solution 2.79kg, using 1.5kg
Yellow pill powder draws light moulding, when drawing light between be 10 minutes, uniformly taken the dish out of the pot to outer surface rounding；
D, ball is once sieved：The wet ball after light will be drawn to be sent to rotary screen and screened first, mesh size for 5.8~
6.5mm, the pill for taking 5.8~6.5mm of particle diameter are first qualified ball, and pill weight variation control range is no more than ± 7.0%, collected
Big or too small pill is waited to reuse；
E, microwave drying, secondary sieve ball：First qualified ball after sieve ball is sent into tunnel type microwave drying sterilizer to carry out
Dry sterilization produces dry ball, sets dry materials temperature as 58 DEG C, and discharging drying temperature is 58 DEG C, transmission speed 2.2m/
Min, for thickness control in 1.1cm, dry ball moisture is 4%；
Then dry ball carries out postsearch screening by rotary screen, and mesh size is：6.0~6.7mm, take particle diameter for 6.0~
6.7mm pill is secondary qualified ball, and pill weight variation control range is no more than ± 7.0%；Secondary qualified ball is passed through into vacuum again
Feeder is sent to spiral pellet selecting machine and screened, and the pill of spiral pellet selecting machine outlet is qualified ball, by the qualified ball of collection
It is fitted into the Plastic Drum of cleaning；Secondary sieve ball yield is 99.1%；
F, the preparation of Dihuang Wan fine powder：Excessive or too small pill, sampling pill and the spiral that collection cylinder filters out
A ball for the unqualified ball outlet of ball machine is selected, is pulverized and sieved by turbine grinder, screen cloth is 100 mesh, is ground into Dihuang Wan fine powder；
It is 95.0% to crush yield；
(4) it is total mixed：Qualified ball after sieve ball is sent in two-dimensional mixing machine by vacuum feeder and mixed, is mixed
6.8 revs/min of revolution, incorporation time 30 minutes, it is fitted into the Plastic Drum of cleaning；Material balance rate is 99.6%；
(5) polishing：
A, medicinal extract is dilute matches somebody with somebody：Stirred 0.7kg purified waters are added in Dihuang Wan medicinal extract 9kg 5 minutes, make solution uniformity.
B, polishing：Pill after total mix is poured into water chestnut type coating machine, seed-coating machine is opened, by the medicinal extract of dilution, glutinous rehmannia
Ball fine powder, 4.2kg talcum powder are sequentially added in water chestnut type coating machine, when pellet surface rounding is uniform, color and luster is consistent, it is smooth when will
Insect wax 0.12kg is added in water chestnut type coating machine, is opened blower fan and is dried 50 minutes, makes pill bright, and color and luster is consistent, and average 10
Ball weight is 1.70g, moisture 2.9%, is taken the dish out of the pot with vacuum charger, produces Dihuang Wan, is condensed pill of the brown to brownish black；Gas
Micro-, sweet and sour, slightly flowers and fruits are fragrant；It is 75min to leach the time；Microorganism detection result is：Aerobic bacteria sum is 20980cfu/
G, mould, saccharomycete sum are 66cfu/g, and bile tolerance gram-negative bacteria should be 78cfu/g, and EHEC does not detect, sramana
Bacterium does not detect.
Table one：Crucial production equipment list
Above content is only to design example and explanation of the invention, affiliated those skilled in the art
Various modifications or supplement are made to described specific embodiment or is substituted using similar mode, without departing from invention
Design or surmount scope defined in the claims, protection scope of the present invention all should be belonged to.
Claims (9)
- A kind of 1. Dihuang Wan, it is characterised in that：It is made up of following parts by weight components：Dihuang Wan medicinal powder 102-126 parts, Dihuang Wan Medicinal extract 100-127 parts, five tastes tonifying Qi powder 12-45 parts, flowers and fruits vinegar 0.1-0.2 parts, starch 3.7-27.5 parts, Icing Sugar 1.11-3.56 Part, talcum powder 4.12-4.3 parts, insect wax 0.1-0.2 parts, 95% ethanol solution 1.5-7 parts；Described Dihuang Wan medicinal powder is by 20.87 parts of moutan bark, 25.2 parts of Fructus Corni, 31.5 parts of Poria cocos, 10.5 parts of Radix Angelicae Sinensis, forges stone 42 parts of Cassia, 10.5 parts of cattail pollen crush the fine powder formed；Described Dihuang Wan medicinal extract is by 96 parts of prepared rhizome of rehmannia, 21 parts of ginger, 31.5 parts of the fruit of Chinese wolfberry, 31 parts of the wind-weed, 31 parts of golden cypress, the root of herbaceous peony 31.5 parts, 31.5 parts of puncture vine, be made after the extraction thick pastes mixing of 31.5 parts of chrysanthemum.
- A kind of 2. Dihuang Wan according to claim 1, it is characterised in that：Described five tastes tonifying Qi powder is by 25 parts of polished rice, de- It is milled and obtains after 11 parts of 12.7 parts of water spinach, 25 parts of soy meal, 8.6 parts of dry longan, Semen sesami nigrum drying.
- A kind of 3. Dihuang Wan according to claim 1, it is characterised in that：Described flowers and fruits vinegar is persimmon vinegar, Hawthorn Vinegar, red Any one in jujube vinegar, mulberry fruit vinegar, Rose vinegar, robiniae,flos vinegar, jelly vinegar.
- A kind of 4. Dihuang Wan according to claim 1, it is characterised in that：Described Icing Sugar is brown sugar powder, royal jelly freezes The mixed powder of powder, brown sugar powder, the weight ratio of royal jelly freeze-dried powder are 5：1.
- A kind of 5. preparation method of Dihuang Wan, it is characterised in that：Specifically include following steps：(1) pre-prepared processA, pulverizing process：A1, Dihuang Wan medicinal powder preparation：Weigh 20.87 parts of moutan bark, 25.2 parts of Fructus Corni, 31.5 parts of Poria cocos, 10.5 parts of Radix Angelicae Sinensis, 10.5 parts of 42 parts of calcined CONCHA HALIOTIDIS, cattail pollen addition pulverizers are ground into fine powder, are stored in fine powder storehouse；A2, the five tastes tonifying Qi powder preparation：Weigh 25 parts of polished rice, 12.7 parts of spinach of dehydration, 25 parts of soy meal, 8.6 parts of dry longan, black Pulverizer is added after 11 parts of drying of sesame and is ground into fine powder, is stored in fine powder storehouse；A3, weigh in mass ratio brown sugar powder, royal jelly freeze-dried powder it is well mixed after sieve, whole operation is entered at low ambient temperatures OK；B, the extraction of Dihuang Wan medicinal extract：Weigh 96 parts of prepared rhizome of rehmannia, 21 parts of ginger, 31.5 parts of the fruit of Chinese wolfberry, 31 parts of the wind-weed, golden cypress 31 Part, 31.5 parts of the root of herbaceous peony, 31.5 parts of puncture vine, 31.5 parts of chrysanthemum are added to the water decoction, collecting decoction, filter, and filtrate is condensed into thick paste, It is stored in standby in freezer；(2) softwood is refinedDihuang Wan medicinal powder, starch, Icing Sugar is weighed to be placed in trough type mixing machine, start it is dry-mixed, then be slowly added into five tastes tonifying Qi powder, Yellow ball medicinal extract, flowers and fruits vinegar and appropriate purified water, wet mixing, obtain softwood semi-finished product, and softwood semi-finished product then are sent into double-deck refining medicine Machine refines to obtain softwood；(3) pillA, test-run a machine：It will be operated in softwood input high efficient full automatic pellet processing machine after refining, regulation ethanol goes out liquid, prevents from gluing Knife, then run formal pill；B, commencement of commercial operation：Weigh Dihuang Wan medicinal powder dusting and connect ball, prevent adhesion, produce wet ball；In pelletizing process, extract pill and claim Record again, and whether the whether uniform rounding of random observation pill, ball face are smooth；Sampling pill used not can return to, and collection is taken out Sample pill is waited to reuse；C, light is drawn：The wet ball made is sent in Dumpage type polishing machine, adds ethanol solution, draws light to mould using Dihuang Wan medicinal powder Shape, uniformly taken the dish out of the pot to outer surface rounding；D, ball is once sieved：Wet ball after drawing light is sent into rotary screen to be screened first, first qualified ball is obtained, collects excessive Or too small pill is waited to reuse；E, microwave drying, secondary sieve ball：First qualified ball after sieve ball is sent into tunnel type microwave drying sterilizer to be dried The dry ball of sterilizing, thus obtaining the product；Then dry ball carries out postsearch screening by rotary screen, obtains secondary qualified ball；Secondary qualified ball is passed through into vacuum feeding again Machine is sent to spiral pellet selecting machine and screened, and the pill of spiral pellet selecting machine outlet is qualified ball, and the qualified ball of collection is loaded In clean Plastic Drum；F, the preparation of Dihuang Wan fine powder：Excessive or too small pill, sampling pill and the spiral pellet selecting that collection cylinder filters out A ball for the unqualified ball outlet of machine, is pulverized and sieved by turbine grinder, obtains Dihuang Wan fine powder；(4) it is total mixed：Qualified ball after sieve ball is sent in two-dimensional mixing machine by vacuum feeder and mixed, is filled after mixing In the Plastic Drum for entering cleaning；(5) polishing：A, medicinal extract is dilute matches somebody with somebody：Add purified water in Dihuang Wan medicinal extract and stir；B, polishing：Pill after total mix is poured into water chestnut type coating machine, opens seed-coating machine, the medicinal extract of dilution, Dihuang Wan is thin Powder, talcum powder are sequentially added in water chestnut type coating machine, are then added insect wax in water chestnut type coating machine, open blower fan blowing, Taken the dish out of the pot with vacuum charger, produce Dihuang Wan.
- A kind of 6. preparation method of Dihuang Wan according to claim 5, it is characterised in that：During dry-mixed described in step (2) Between be 10 minutes；The appropriate purified water of described addition is to determine purifying water consumption with softwood soft durometer, adds the amount of purified water For the 19.5%-21.1% of starch addition；The described wet mixing time is 3-5 minutes.
- A kind of 7. preparation method of Dihuang Wan according to claim 5, it is characterised in that：It is efficient complete described in step (3) a The shaping bore dia of automatic pill-making machine is 5.9-6.5mm, and tool diameter 6.3-6.7mm, defeated bar FREQUENCY CONTROL is 25-35Hz.
- A kind of 8. preparation method of Dihuang Wan according to claim 5, it is characterised in that：Operation described in step (3) a is just The condition of formula pill is that can be run when every 10 balls are focused in 1.80~2.00g hairs；The amount for weighing Dihuang Wan medicinal powder described in step (3) b is the 1%-3% of total glutinous rehmannia pill powder；In described pelletizing process, 10 balls were taken to weigh from every high efficient full automatic pellet processing machine every 20 minutes；Ethanol solution described in step (3) c is 95% ethanol and the mixed liquor of purified water, and 95% ethanol is with purifying water weight ratio 3.75:1；The described amount using Dihuang Wan medicinal powder is the 1%-3% of total glutinous rehmannia pill powder；10-15 points between during described drawing light Clock；Rotary screen mesh size described in step (3) d is 5.8~6.5mm；The pill weight variation control range of described first qualified ball is no more than ± 7.0%；The rotary screen mesh size of postsearch screening described in step (3) e is 6.0~6.7mm；The ball weight of described secondary qualified ball Difference control range is no more than ± 7.0%；Described transmission speed is 1.5-2.5m/min；Described secondary sieve ball high income reaches 99.6%；Mesh size described in step (3) f is 100 mesh, crushes high income up to 97%.
- A kind of 9. preparation method of Dihuang Wan according to claim 5, it is characterised in that：Step (5) b adds insect wax Precondition be when pellet surface rounding is uniform, color and luster is consistent, it is smooth when can add；Described blow-time is 40-60 points Clock.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710884752.2A CN107569667A (en) | 2017-09-26 | 2017-09-26 | A kind of Dihuang Wan and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710884752.2A CN107569667A (en) | 2017-09-26 | 2017-09-26 | A kind of Dihuang Wan and preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107569667A true CN107569667A (en) | 2018-01-12 |
Family
ID=61038562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710884752.2A Pending CN107569667A (en) | 2017-09-26 | 2017-09-26 | A kind of Dihuang Wan and preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107569667A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108514551A (en) * | 2018-05-18 | 2018-09-11 | 北京同仁堂制药有限公司 | A kind of preparation method of medicine pill |
| CN113908135A (en) * | 2021-11-10 | 2022-01-11 | 北京同仁堂科技发展股份有限公司制药厂 | Preparation method of water-honeyed pill |
| CN116159120A (en) * | 2022-04-08 | 2023-05-26 | 浙江三溪堂中药有限公司 | Liver-protecting and spleen-clearing traditional Chinese medicine composition, pill, preparation method and application |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103599490A (en) * | 2013-11-29 | 2014-02-26 | 成都九芝堂金鼎药业有限公司 | Preparation method of traditional Chinese medicine pill for treating periodontitis |
| CN106511094A (en) * | 2016-12-02 | 2017-03-22 | 芜湖市诺康生物科技有限公司 | Pelleting machine |
-
2017
- 2017-09-26 CN CN201710884752.2A patent/CN107569667A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103599490A (en) * | 2013-11-29 | 2014-02-26 | 成都九芝堂金鼎药业有限公司 | Preparation method of traditional Chinese medicine pill for treating periodontitis |
| CN106511094A (en) * | 2016-12-02 | 2017-03-22 | 芜湖市诺康生物科技有限公司 | Pelleting machine |
Non-Patent Citations (4)
| Title |
|---|
| 国家药典委员会: "《中华人民共和国药典：2015年版.一部》", 30 June 2015, 中国医药科技出版社 * |
| 孙世发: "《中华医方 妇科篇》", 31 March 2015, 科学技术文献出版社 * |
| 李慧等: "微波干燥技术在浓缩丸生产中的应用", 《中国实验方剂学杂志》 * |
| 陆善旦等: "《补气、补血药粥》", 31 March 2003, 广西科学技术出版社 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108514551A (en) * | 2018-05-18 | 2018-09-11 | 北京同仁堂制药有限公司 | A kind of preparation method of medicine pill |
| CN113908135A (en) * | 2021-11-10 | 2022-01-11 | 北京同仁堂科技发展股份有限公司制药厂 | Preparation method of water-honeyed pill |
| CN116159120A (en) * | 2022-04-08 | 2023-05-26 | 浙江三溪堂中药有限公司 | Liver-protecting and spleen-clearing traditional Chinese medicine composition, pill, preparation method and application |
| CN116159120B (en) * | 2022-04-08 | 2024-03-12 | 浙江三溪堂中药有限公司 | Liver-protecting and spleen-clearing traditional Chinese medicine composition, pill, preparation method and application |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106983057A (en) | One seed ginseng Qi Chinese yam sealwort solid beverage and its preparation technology | |
| CN107569667A (en) | A kind of Dihuang Wan and preparation method | |
| CN105661525A (en) | Preparation method of glossy privet leaf and quince nutritional tablets | |
| CN105288215A (en) | High-activity dendrobium officinale kimura et migo freeze-drying powder buccal tablets and preparation process thereof | |
| CN103039981B (en) | Mung bean-konjac soup and preparation method thereof | |
| CN102389077B (en) | Cordyceps tsamba | |
| CN102630949B (en) | Insoluble dietary fiber and manufacturing method for insoluble dietary fiber | |
| CN109349635A (en) | A kind of health-preserving paste improving yin-deficiency constitution | |
| CN108901706A (en) | A kind of cultural method creating rice multifunctionality | |
| CN102670660B (en) | Processing method and application of aspongopus | |
| CN109010452A (en) | A kind of Orthopeadic Surgery nursing drug for traumatic injuries and preparation method thereof | |
| CN108853335A (en) | One kind is recovered lost hearing ball and preparation method thereof of having one's ideas straightened out | |
| CN105876321A (en) | Preparation method of colored polished glutinous rice | |
| CN107125531A (en) | One seed ginseng Pueraria lobota medlar nutriment strengthens solid beverage and its preparation technology | |
| CN102038898B (en) | Method for preparing alpinia oxyphylla | |
| CN113425809A (en) | Method and device for making nerve-soothing and sleep-aiding medicinal tea | |
| CN107551248A (en) | A kind of ease pill and production technology | |
| CN105557910A (en) | Making method of nutgrass galingale rhizome, radix puerariae and starfruit cake rolls | |
| CN110420233A (en) | A kind of preparation method of Cordyceps militaris ginseng matsutake piece | |
| CN101744245A (en) | Soft capsule of royal jelly and schisandra fruit and preparation method thereof | |
| CN111557578A (en) | Traditional Chinese medicine health-preserving medicine pillow and preparation method thereof | |
| CN109965278A (en) | A kind of health nutrient powder | |
| CN103583981A (en) | Health-care allium tuberosum noodle and production method thereof | |
| CN106615500A (en) | Coffee health care jelly | |
| CN106539007A (en) | A kind of medicated diet cake formulation of enhancing immunity |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180112 |