CN107801990A - A kind of health food of auxiliary hyperglycemic and preparation method thereof - Google Patents

A kind of health food of auxiliary hyperglycemic and preparation method thereof Download PDF

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Publication number
CN107801990A
CN107801990A CN201711238078.7A CN201711238078A CN107801990A CN 107801990 A CN107801990 A CN 107801990A CN 201711238078 A CN201711238078 A CN 201711238078A CN 107801990 A CN107801990 A CN 107801990A
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extract
fruit
health food
chinese
auxiliary hyperglycemic
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李丹
叶丽芳
董宏然
吕晓霞
王青标
留梦甜
李文明
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HANGZHOU NEPTUNUS BIOENGINEERING CO Ltd
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HANGZHOU NEPTUNUS BIOENGINEERING CO Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
    • A23L19/09—Mashed or comminuted products, e.g. pulp, purée, sauce, or products made therefrom, e.g. snacks
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
    • A23L19/10—Products from fruits or vegetables; Preparation or treatment thereof of tuberous or like starch containing root crops
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/14—Yeasts or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/20—Agglomerating; Granulating; Tabletting
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/064—Saccharomycetales, e.g. baker's yeast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/79—Schisandraceae (Schisandra family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8964—Anemarrhena
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968—Ophiopogon (Lilyturf)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The invention discloses a kind of health food of auxiliary hyperglycemic and preparation method thereof.The health food includes following components according to weight percentage：The Radix Astragali or Astragalus Root P.E 1 50%, the root of kudzu vine or kudzu root extract 1 50%, glutinous rehmannia or glutinous rehmannia extract 1 50%, the wind-weed or anemarrhena asphodefoides extract 0 25%, the tuber of dwarf lilyturf or ophiopogon japonicus extract 1 50%, the fruit of Chinese wolfberry or Fructus lycii P.E 0 50%, the fruit of Chinese magnoliavine or fruit of Chinese magnoliavine extraction 1 50%, Chinese yam or yam extract 0 25%, mulberry leaf or mulberry-leaf extract 0 25%, Cr-enriched yeast 0.01 5%.The health food function of blood sugar reduction of the auxiliary hyperglycemic of the present invention is clear and definite, safe without toxic side effect, instant.

Description

A kind of health food of auxiliary hyperglycemic and preparation method thereof
Technical field
The present invention relates to field of medicaments, more particularly to a kind of health food of auxiliary hyperglycemic and preparation method thereof.
Background technology
Diabetes are one of most common epidemic diseases of world wide, have become after angiocardiopathy, tumour The disease of three big serious threat human healths.Patient normally behaves as more drinks, more food, diuresis, weight loss, also with it is fatty, Protein metabolism is disorderly, easily concurrent vascular lesion, DKA.According to《Chinese residents nourishment and chronic disease status report (2015)》, 2012 China 18 years old and above diabetic illness rate be 9.7%, patient numbers about 100,000,000.In recent years, with The improvement of people's living standards, aging population and work and living-pattern preservation, the incidence of disease of hyperglycaemia becomes in rising Gesture, and tend to rejuvenation.
At present, the conventional treatment drug of diabetes is mainly Insulin secretagogues, alpha-glucosidase restrainer, pancreas islet The chemicalses such as plain sensitizer and insulin.It is long-term use of although OHA can effectively control blood glucose level in patients Certain side effect can be produced afterwards, it is possible to further aggravate the infringement of organ, or even drug resistance occur, and administering mode also has Inconvenience.Simultaneously these medicines to diabetes in advance and chronic complicating diseases are without preferable control effect, easily cause low blood Sugar or lactic acidosis, and can not prevent the further necrosis of beta Cell of islet, cause insulin the side effect such as to further rely on. Function of health food is clear and definite, does not have any acute, subacute and chronic hazard to human body, therefore it is convenient to take, easy to be badly in need of development In storage and the hypoglycemia healthcare food carried.
In long-term medical practice, China's traditional medicine have accumulated many invaluable experiences, and modern pharmacology research shows Chinese herbal medicine has remarkable effect in terms of preventing and treating diabetes and various chronic complicating diseases." 200310115012.0 is a kind of for patent application Disclosed in medicine for the treatment of diabetes and preparation method thereof " using American Ginseng, the Radix Astragali, Chinese yam, radix rehmanniae recen, Fructus Corni, matrimony vine Chinese medicine composition is made in son, the tuber of dwarf lilyturf, the wind-weed, root of Chinese trichosanthes, the fruit of Chinese magnoliavine, Chinese gall, the root of kudzu vine, and it has obvious hypoglycemic work With.Disclosed in patent application " a kind of traditional Chinese medicinal composition with effect of reducing blood sugar of 201210524373.X " by Semen sesami nigrum, arillus longan, mulberry Shen, radix rehmanniae recen, the tuber of dwarf lilyturf, root of Chinese trichosanthes, the Radix Astragali, the fruit of Chinese wolfberry, the root of kudzu vine, red ginseng, Poria cocos, moutan bark, the fruit of Chinese magnoliavine, spina date seed, the seed of Oriental arborvitae, Cortex albiziae, the stem of noble dendrobium, the fruit of Chinese wolfberry, the fruit of glossy privet, the molecular Chinese medicines of lily, Chuan Su, it can improve the symptom of diabetic. But Chinese medicine composition also has many defects in the prior art, fail to understand such as preparation technology complexity, expensive starting materials, by hypoglycemic effect The problems such as really or having much room for improvement.
The content of the invention
In view of the above problems, it is an object of the invention to provide a kind of health food of auxiliary hyperglycemic and its preparation side Method.The health food function of blood sugar reduction of the auxiliary hyperglycemic of the present invention is clear and definite, safe without toxic side effect, instant.
The used to achieve the above object technical scheme of the present invention is：
A kind of health food of auxiliary hyperglycemic, include following components according to weight percentage：
The Radix Astragali or Astragalus Root P.E 1-50%, the root of kudzu vine or kudzu root extract 1-50%, glutinous rehmannia or glutinous rehmannia extract 1-50%, The wind-weed or anemarrhena asphodefoides extract 0-25%, the tuber of dwarf lilyturf or ophiopogon japonicus extract 1-50%, the fruit of Chinese wolfberry or Fructus lycii P.E 0-50%, the five tastes Son or fruit of Chinese magnoliavine extraction 1-50%, Chinese yam or yam extract 0-25%, mulberry leaf or mulberry-leaf extract 0-25%, Cr-enriched yeast 0.01-5%.
Preferably, primary raw material includes according to weight percent content：The Radix Astragali or Astragalus Root P.E 5-25%, the root of kudzu vine or Pueraria lobota Root extract 2.5-12.5%, glutinous rehmannia or glutinous rehmannia extract 5-25%, the wind-weed or anemarrhena asphodefoides extract 1-10%, the tuber of dwarf lilyturf or the tuber of dwarf lilyturf carry Take thing 2.5-12.5%, the fruit of Chinese wolfberry or Fructus lycii P.E 2.5-12.50%, the fruit of Chinese magnoliavine or fruit of Chinese magnoliavine extraction 1-10%, Chinese yam Or yam extract 1-10%, mulberry leaf or mulberry-leaf extract 1-10%, Chinese yam or yam extract 1-10%, Cr-enriched yeast 0.01-4%.
The above-mentioned raw material with auxiliary hyperglycemic function is have chosen, according to Traditional Chinese medical theory and modern medicine study knot Fruit, its prescription have collaboration hypoglycemic effect, without any incompatibility, can not only reduce blood glucose, it is each can also to strengthen body Item function, protects islet tissue, improves the sensitiveness of insulin, delays or even prevent the generation of diabetic complication.
The Radix Astragali is the dry root of legume astragalus mongolicus or Astragalus membranacus, sweet, slightly warm in nature.The medicinal history of the Radix Astragali is swung Long, be one of important drugs for quenching one's thirst of ancient times treatment, it has a tonifying Qi and lifting yang, inducing diuresis for removing edema, promote the production of body fluid blood-nourishing the effect of.Modern medicine Pharmacological research shows that Radix Astragali water extract, astragalus polyose and Astragaloside IV have significant hypoglycemic effect, can also protect pancreas Island β cells, prevention diabetic complication and improvement hemorheology index.
The root of kudzu vine is the dry root of legume pueraria lobata, Xin Gan and it is cool, have and inspire that the gas of the clear sun of taste is up, promotes the production of body fluid to quench thirst Effect.The root of kudzu vine is rich in Flavonoid substances, and Puerarin therein has good reduction fasting blood-glucose, increase sugar tolerance, improves blood Clear insulin level, improve the effect such as glycolipid metabolism, definite functions.
Glutinous rehmannia is the dried root of scrophulariaceae rehmannia glutinosa plant, sweet, cold in nature.Radix rehmanniae recen bitter cold is let out clearly, sweet matter profit, is had Clearing heat and cooling blood, the effect of nourishing Yin and promoting production of body fluid.Modern pharmacology research shows that it is big that the oligosaccharides in glutinous rehmannia can adjust diabetes model Mouse, the glycolipid metabolism of mouse, therapeutic action is respectively provided with to obese diabetes rat and diabetic nephropathy rats.
The wind-weed is the dry rhizome of the liliaceous plant wind-weed, bitter, sweet, cold in nature.The wind-weed is apt to the heat of clear Jiao of upper, middle and lower three, arrogates to oneself Long Yin-nourishing and body fluid promoting is moisturized, and is the conventional Chinese medicine for treating diabetes.Research finds that the wind-weed has a variety of pharmacological activity, such as disease-resistant original Microorganism, antipyretic and anti-inflammatory effect, antiplatelet aggregative activity and hypoglycemic effect.
The tuber of dwarf lilyturf be the liliaceous plant tuber of dwarf lilyturf dried root, sweet and slightly bitter taste, cold nature.The tuber of dwarf lilyturf both nourishing Yin and promoting production of body fluid and moistening lung is beneficial Stomach, but clear nourishing the heart to keep a sound mind and relieving restlessness is calmed the nerves, can also moisten intestinal dryness and defaecation.Pharmacological research shows that the tuber of dwarf lilyturf has strengthen immunity, resisted The pharmacological actions such as aging, resisting cardiovascular disease, anti-inflammatory, antibechic, while ophiopogonpolysaccharide has significant hypoglycemic, improvement pancreas islet Element resistance and Renoprotective Effect.
The fruit of Chinese wolfberry be plant of Solanaceae lycium barbarum dry mature fruit, sweet, mild-natured partial temperature.Matrimony vine has nourishing liver The effect of kidney, benefiting shrewd head.The fruit of Chinese wolfberry is widely used, and is the Chinese medicine of medicine-food two-purpose simply, and security is good.Modern medicine study Show, LBP-X not only can also protect retina, treatment regards with hypoglycemic, repairing islet cells, recovery islet function Retinopathy.
The fruit of Chinese magnoliavine is the dry mature fruit of magnoliaceae schisandra, sour, warm-natured.It is astringent or styptic treatment for spontaneous sweating with restraining, QI invigorating life Tianjin, the effect of kidney calming.Because the fruit of Chinese magnoliavine has the function that to hold back cloudy Gu Yin, other medicines can be strengthened in the Ricipe for health care food The nourishing Yin and promoting production of body fluid effect of material.Modern medicine study shows that Chinese Magnoliavine Fruit alcohol extract, water extract and fruit of Chinese magnoliavine decoction are respectively provided with simultaneously Hypoglycemic, reducing blood lipid, protection kidney, the effect for repairing beta Cell of islet, its hypoglycemic effect are notable.
Chinese yam is the dry rhizome of Dioscoreaceae plant Chinese yam, sweet, mild-natured.The Chinese yam efficacy of a drug is gentle, and the puckery property held back, and both puts down Tonifying Qi is cloudy, to control the good merchantable brand of the deficiency of vital energy or deficiency of both qi and yin, and enriching yin boost qi and promote the production of body fluid, commonly used to control kidney-yin deficiency and quenching one's thirst.Simultaneously Chinese yam is also the very high integration of drinking and medicinal herbs food of nutritive value, have strengthen immunity, adjustment functions of intestines and stomach, hypoglycemic, reducing blood lipid, Anti-aging and other effects.
Mulberry leaf are the dried leaf of moraceae plants mulberry, sweet, bitter, cold in nature.Contain 1-DNJ in mulberry leaf, be α-Portugal The inhibitor of polyglycoside enzyme and glucoamylase, there is obvious suppression postprandial blood sugar to rise, lose weight and increase insulin is quick The effect of perception.
Cr-enriched yeast is by way of manually developing, and using yeast as carrier, turns out the edible for being enriched with chromium Feature yeast.Chromium is one of the essential trace elements of the human body, and modern study confirms that trivalent chromium is GTF (GTF) Active part, mainly by GTF cooperate with and strengthen insulin effect, so as to influence the generation of carbohydrate, fat, protein Thank.Cr-enriched yeast has edible safety, non-toxic, and human absorptivity is high, and it is many to supplement B family vitamin etc. while supplementing chromium Advantage.
Also include filler and flavouring, described filler be selected from pregelatinized starch, microcrystalline cellulose, maltodextrin, One or more in D-mannital, xylitol, maltitol, isomaltoketose, described flavouring be selected from flavoring essence, One or both of citric acid；The adhesive and wetting agent used in pelletization is additionally included in, described adhesive is selected from One or more in PVP, hydroxypropyl methylcellulose, sodium carboxymethylcellulose, starch slurry, described wetting agent are selected from purifying One or both of water, ethanol.Addition filler and flavouring are to increase the mobility of material and adjustment granule Taste, it is the demand for granule or capsule granulation to add adhesive and wetting agent.Wherein filler and flavouring, viscous Mixture and wetting agent can need the property with material according to formula, and selection is added or do not added.
Preferably, filler and flavouring include according to weight percent content：Pregelatinized starch 5-50%, microcrystalline cellulose Plain 5-30%, maltodextrin 5-50%, D-mannital 5-50%, xylitol 5-50%, maltitol 1-20%, different malt ketone Sugared 1-20%, flavoring essence 0.1-5%, citric acid 0.1-5%；The adhesive and wetting agent used in pelletization is selected from pure Change water 1-40%, ethanol 10-70%, PVP 1-40%, hydroxypropyl methylcellulose 1-40%, sodium carboxymethylcellulose 1-40%, Starch slurry 1-40%.
Preferably, health food is granule or capsule.
The preparation method of above-mentioned assistant hypoglycemia healthcare food, comprises the following steps：
Granule：
(1) pulverize and sieve, the filler and flavouring that raw material, needs are added determine whether to carry out according to its particle sizes Crush, if raw material, filler and flavouring be able to need not be crushed by 80-100 mesh sieves, if can not pass through 80- 100 mesh sieves, then need to pulverize and sieve, ensure that the granularity of each raw material, filler and flavouring is consistent, ensure follow-up well mixed；
(2) weigh, the filler and flavouring that raw material, needs are added carry out accurate weighing, standby；
(3) mix, load weighted each material is mixed according to formula；
(4) pelletize, according to the material properties mixed, select suitable adhesive and wetting agent, pelletized, reaching needs The granularity 20-60 mesh wanted；
(5) particle made is packed, be put in storage.
Capsule：
(1) pulverize and sieve, the filler and flavouring that raw material, needs are added determine whether to carry out according to its particle sizes Crush, if raw material, filler and flavouring be able to need not be crushed by 80-100 mesh sieves, if can not pass through 80- 100 mesh sieves, then need to pulverize and sieve, ensure that the granularity of each raw material, filler and flavouring is consistent, ensure follow-up well mixed；
(2) weigh, the filler and flavouring that raw material, needs are added carry out accurate weighing, standby；
(3) mix, load weighted each material is mixed according to formula；
Decide whether to be pelletized according to the material fluidity after formula combination, if good fluidity, be directly entered encapsulating capsule The step of (5)；If mobility is bad, the step of needing first to be pelletized (4), then the step of carry out encapsulating capsule (5)；
(4) pelletize, according to the material properties mixed, select suitable adhesive and wetting agent, pelletized, reaching needs The granularity 20-80 mesh wanted；
(5) encapsulating capsule, the material mixed or the particle made are subjected to encapsulating capsule；
(6) capsule filled is packed, be put in storage.
The present invention has the following technical effect that：
(1) assistant hypoglycemia healthcare food formulation manipulation of the present invention is according to Traditional Chinese medical theory and modern scientific research Achievement, which is combined, carrys out prescription.In formula：The Radix Astragali, root of kudzu vine tonifying Qi and lifting yang, promote the production of body fluid to quench thirst, glutinous rehmannia, wind-weed heat-clearing enriching yin, the tuber of dwarf lilyturf, Chinese holly Matrimony vine, Chinese yam promote the production of body fluid to quench thirst, the five internal organs with mending, cloudy Gu Yin is held back in fruit of Chinese magnoliavine nourshing kidney calming heart, and the 1- deoxidations open country buttocks in mulberry-leaf extract is mould Element is potent alpha-glucosidase restrainer, can significantly reduce diabetic's fasting blood-glucose and postprandial blood sugar, in Cr-enriched yeast It is the important component of glucose tolerance factor rich in trivalent chromium, insulin active can be increased, enhancing diabetes B is suffered from Person's insulin sensitivity., can be from number of ways reasonable adjusting blood glucose without incompatibility between each raw material of the prescription.
(2) target group of the present invention is clear and definite, has the function that to treat both principal and secondary aspect of disease to diabetic, utilizes Traditional Chinese medical theory Be combined with modern medicine, it is common to reduce the blood glucose target of high blood glucose crowd, while mitigate diabetic population complication and Take side effect caused by Western medicine hypoglycemic medicine.
(3) granule and capsule preparation technology of the present invention is simple, and product instant, is easy to carry about with one, the scope of application Extensively.
Embodiment
Specific examples below is the further explanation to method provided by the invention and technical scheme, but is not construed as Limitation of the present invention.
Embodiment 1：
Choose 6 kinds of primary raw material Astragalus Root P.Es, kudzu root extract, glutinous rehmannia extract, ophiopogon japonicus extract, fruit of Chinese magnoliavine extraction Thing, Cr-enriched yeast, addition maltodextrin, D-mannital, maltitol are filler and flavouring.The Radix Astragali, glutinous rehmannia, the tuber of dwarf lilyturf, The fruit of Chinese magnoliavine is the article available for health food, and the root of kudzu vine is the material of integration of drinking and medicinal herbs, does not have incompatibility, group between each raw material Safety issue is not present in side.
Specific formula composition is (weight percent)：
Astragalus Root P.E：10-20
Kudzu root extract：5-10
Glutinous rehmannia extract：10-20
Ophiopogon japonicus extract：5-10
Schisandra chinens P.E：5-10
Cr-enriched yeast：0.1-2
Maltodextrin：20-40
D-mannital：10-30
Maltitol：10-20
70% ethanol：The 20%-50% of mixed material weight.
Production and processing method is as follows：
(1) pulverize and sieve：Above-mentioned supplementary material is pulverized and sieved, 100% by 80 mesh sieves, standby；
(2) weigh：Above-mentioned supplementary material is weighed by formula rate；
(3) mix：Load weighted material in (2) is loaded into stirring 30min in mixer；
(4) pelletize：According to the material properties mixed in (3), mass fraction is selected to be pelletized for 70% ethanol, The granularity of grain reaches 20-60 mesh；
(5) pack：The particle made in (4) is dispensed, is put in storage.
Granule obtained by embodiment 1 has carried out auxiliary hyperglycemic function animal experiment：
First, test method：
(1) insulin damage hyperglycemia model method.
1 experimental animal and dosage：Experiment ICR mouse, cleaning grade, male, 26 ± 2g of body weight.Setup Experiments are basic, normal, high Three dosage groups, respectively 0.25,0.5,1.5g/kg body weight, gavage capacity presses 0.1ml/10g batheroom scales.
2nd, intact animal hypoglycemic is tested：Take 20 mouse, after fasting 4 hours, take mouse tail blood to survey blood glucose, by blood sugar level Be divided into 1 control group and 1 high dose group, every group 10, respectively gavage give deionized water and high dose sample, continuous 30 My god, after each group animal fasting 4 hours, fasting blood sugar is surveyed, compares two groups of mouse fasting blood sugars.
3rd, hyperglycemia model hypoglycemic is tested：
(1) islet damage hyperglycemia model：120 mouse take 15 fasting 4 hours at random, blood glucose are surveyed, as the batch Animal basal plasma glucose value.Subsequent strict fasting 24 hours (free water), mouse tail vein injection alloxan 45mg/kg.BW, Fasting 4 hours after 7 days, survey blood glucose.Screening fasting blood sugar is 10-25mmol/L mouse 52, is divided at random by blood sugar level For 1 model control group and basic, normal, high dosage group.
(2) fasting blood-glucose and the measure of sugar tolerance：Gavage gives the sample of deionized water and various dose respectively, and continuous 30 My god, after each group animal fasting 4 hours, survey fasting blood sugar, i.e. 0 hour blood glucose value.Each dosage group gives various concentrations sample, mould Type group control group gives same volume deionized water, and each group gavage gives glucose 2.0g/kg.BW after 20 minutes, determines to grape The blood glucose value of 0.5,2 hour after sugar, compare fasting blood sugar and blood glucose decline percentage before and after each group mouse experiment；0.5、2.0 Hour blood glucose value and Area under the curve of blood glucose.
Blood glucose value before blood glucose rate of descent (%)=(blood glucose value after blood glucose value-experiment before experiment) × 100/ is tested
Area under the curve of blood glucose=(0h blood glucose+0.5h blood glucose) × 0.5/2+ (0.5h blood glucose+2h blood glucose) × 1.5/2
(2) experimental data counts：Experimental data is counted using SPSS11.5 statistical softwares.Negative control group and high agent Each Indexes Comparison is examined using t between amount group.In addition to blood glucose rate of descent, model control group and each index of three dosage groups are using equal Number ± standard deviationRepresent, compare between each group and variance analysis is used after homogeneity test of variance variance is neat.Blood glucose rate of descent Using quartile (P25~P75) represent, the comparison between blood glucose rate of descent each group uses rank test.
2nd, experimental result
1st, sample is to normal and hyperglycemia model mouse weight influence
The sample of table 1 is to normal and hyperglycemia model mouse weight influence
From table 1, sample high dose group (feminine gender) mouse experiment initial stage, mid-term and it is final respectively and negative control group Compare, there are no significant for difference (P ＞ 0.05)；The basic, normal, high dosage group mouse of sample is testing each phase respectively and model control group Compare, there are no significant for difference (P ＞ 0.05).
2nd, sample is to normal and hyperglycemia model mouse fasting blood-glucose influence
The sample of table 2 is to normal and hyperglycemia model mouse fasting blood-glucose influence
As shown in Table 2, mouse fasting blood sugar and negative control group compare before and after sample high dose group (feminine gender) experiment, poor Different no conspicuousness (P ＞ 0.05)；Fasting blood sugar and blood glucose decline percentage before and after the basic, normal, high dosage group mouse test of sample Compare respectively with model control group, there are no significant for difference (P ＞ 0.05).
3rd, influence of the sample to hyperglycemia model glucose tolerance in mice
Influence of the sample of table 3 to hyperglycemia model glucose tolerance in mice
From table 3, compared with model control group, 2 hours blood glucose values of sample middle dose group sugar tolerance substantially reduce, difference There is conspicuousness (P ＜ 0.05).
Test result indicates that：Auxiliary drop blood is carried out using the assistant hypoglycemia healthcare food granule of embodiment 1 as sample Sugared animal experiment, under this experiment condition, experimental result is the positive.
Embodiment 2：
Selection takes 7 kinds of primary raw material Astragalus Root P.Es, kudzu root extract, glutinous rehmannia extract, ophiopogon japonicus extract, fruits of Chinese wolfberry to carry Thing, Schisandra chinens P.E, Cr-enriched yeast are taken, addition microcrystalline cellulose, magnesium stearate are filler.The Radix Astragali, glutinous rehmannia, the tuber of dwarf lilyturf, five Taste is the article available for health food, and the root of kudzu vine, the Chinese medicine that the fruit of Chinese wolfberry is integration of drinking and medicinal herbs, Cr-enriched yeast belong to nutrient thing Matter, there is no incompatibility between each raw material, safety issue is not present in prescription.
Specific formula composition is (weight percent)：
Astragalus Root P.E：10-20
Kudzu root extract：5-10
Glutinous rehmannia extract：10-20
Ophiopogon japonicus extract：5-10
Fructus lycii P.E：5-10
Schisandra chinens P.E：5-10
Cr-enriched yeast：0.1-2
Microcrystalline cellulose：20-40
Magnesium stearate 0.5-1.5.
Production and processing method is as follows：
(1) pulverize and sieve：Above-mentioned supplementary material is pulverized and sieved, 100% by 80 mesh sieves, standby；
(2) weigh：Above-mentioned supplementary material is weighed by formula rate；
(3) mix：Load weighted material in (2) is loaded into stirring 30min in mixer；
(4) encapsulating capsule：The material mixed in (3) is subjected to encapsulating capsule；
(5) pack：The capsule filled in (4) is dispensed, is put in storage.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art For member, under the premise without departing from the principles of the invention, various changes can be carried out to these features and embodiment or equivalent are replaced Change.In addition, under the teachings of the present invention, these features and embodiment can be modified to adapt to particular situation and material And mend and depart from the spirit and scope of the present invention.Therefore, the present invention is not limited to the particular embodiment disclosed, Suo Youluo Enter the embodiment in the range of claims hereof and belong to protection scope of the present invention.

Claims (8)

1. a kind of health food of auxiliary hyperglycemic, it is characterised in that include following components according to weight percentage：The Radix Astragali or Astragalus Root P.E 1-50%, the root of kudzu vine or kudzu root extract 1-50%, glutinous rehmannia or glutinous rehmannia extract 1-50%, the wind-weed or wind-weed extraction Thing 0-25%, the tuber of dwarf lilyturf or ophiopogon japonicus extract 1-50%, the fruit of Chinese wolfberry or Fructus lycii P.E 0-50%, the fruit of Chinese magnoliavine or fruit of Chinese magnoliavine extraction 1-50%, Chinese yam or yam extract 0-25%, mulberry leaf or mulberry-leaf extract 0-25%, Cr-enriched yeast 0.01-5%.
2. the health food of auxiliary hyperglycemic as claimed in claim 1, it is characterised in that raw material is according to weight percent content For：The Radix Astragali or Astragalus Root P.E 5-25%, the root of kudzu vine or kudzu root extract 2.5-12.5%, glutinous rehmannia or glutinous rehmannia extract 5-25%, The wind-weed or anemarrhena asphodefoides extract 1-10%, the tuber of dwarf lilyturf or ophiopogon japonicus extract 2.5-12.5%, the fruit of Chinese wolfberry or Fructus lycii P.E 2.5- 12.50%th, the fruit of Chinese magnoliavine or fruit of Chinese magnoliavine extraction 1-10%, Chinese yam or yam extract 1-10%, mulberry leaf or mulberry-leaf extract 1- 10%th, Chinese yam or yam extract 1-10%, Cr-enriched yeast 0.01-4%.
3. the health food of auxiliary hyperglycemic as claimed in claim 1, it is characterised in that also including filler and flavouring, Described filler is selected from pregelatinized starch, microcrystalline cellulose, maltodextrin, D-mannital, xylitol, maltitol, different One or more in maltulose, described flavouring are selected from one or both of flavoring essence, citric acid.
4. the health food of auxiliary hyperglycemic as claimed in claim 1, it is characterised in that be additionally included in pelletization and use Adhesive and wetting agent, described adhesive is in PVP, hydroxypropyl methylcellulose, sodium carboxymethylcellulose, starch slurry One or more, described wetting agent is selected from purified water, one or both of ethanol.
5. the health food of auxiliary hyperglycemic as claimed in claim 4, it is characterised in that described filler and flavouring exists It is according to weight percent content in raw material：Pregelatinized starch 5-50%, microcrystalline cellulose 5-30%, maltodextrin 5-50%, D-mannital 5-50%, xylitol 5-50%, maltitol 1-20%, isomaltoketose 1-20%, flavoring essence 0.1- 5%th, citric acid 0.1-5%.
6. the health food of auxiliary hyperglycemic as claimed in claim 5, it is characterised in that described adhesive and wetting agent exists It is according to weight percent content in raw material：Purified water 1-40%, ethanol 10-70%, PVP 1-40%, hydroxypropyl methylcellulose 1-40%, sodium carboxymethylcellulose 1-40%, starch slurry 1-40%.
7. the health food of auxiliary hyperglycemic as claimed in claim 6, it is characterised in that the health care of described auxiliary hyperglycemic Food is granule or capsule.
8. the health food of the auxiliary hyperglycemic as any one of claim 3-7, it is characterised in that including following step Suddenly：
(1) alternatively, pulverize and sieve, raw material, filler and flavouring are crossed into 80-100 mesh sieves；
(2) weigh, raw material, filler and flavouring are weighed, it is standby；
(3) mix, load weighted material is mixed according to formula；
(4) alternatively, adhesive and wetting agent are added, is pelletized, reaches the granularity 20-60 mesh of needs；
(5) pack, storage or further encapsulating capsule, the capsule filled is packed, is put in storage.
CN201711238078.7A 2017-11-30 2017-11-30 A kind of health food of auxiliary hyperglycemic and preparation method thereof Pending CN107801990A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109007785A (en) * 2018-09-26 2018-12-18 上饶市康可得生物科技有限公司 A kind of auxiliary hyperglycemic blood fat reducing healthcare food
CN110314196A (en) * 2019-08-17 2019-10-11 哈尔滨工业大学 A kind of preparation method of mulberry leaf compound hypoglycemic instant

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1618446A (en) * 2003-11-19 2005-05-25 王锦刚 Medicine for treating diabetes, and its prepn. method
CN106666312A (en) * 2017-01-11 2017-05-17 大连雅威特生物技术股份有限公司 Health-care food for assisting blood glucose decreasing and preparation method of granule and capsule thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1618446A (en) * 2003-11-19 2005-05-25 王锦刚 Medicine for treating diabetes, and its prepn. method
CN106666312A (en) * 2017-01-11 2017-05-17 大连雅威特生物技术股份有限公司 Health-care food for assisting blood glucose decreasing and preparation method of granule and capsule thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109007785A (en) * 2018-09-26 2018-12-18 上饶市康可得生物科技有限公司 A kind of auxiliary hyperglycemic blood fat reducing healthcare food
CN110314196A (en) * 2019-08-17 2019-10-11 哈尔滨工业大学 A kind of preparation method of mulberry leaf compound hypoglycemic instant

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