CN107625129A - A kind of hypoglycemic and the health food and its production method of reducing blood lipid - Google Patents
A kind of hypoglycemic and the health food and its production method of reducing blood lipid Download PDFInfo
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Abstract
The invention discloses a kind of hypoglycemic and the health food and its production method of reducing blood lipid, described hypoglycemic and reducing blood lipid health food is counted in parts by weight, is made up of following raw material：13 parts of 25 parts of mulberry leaf, 16 parts of balsam pear, 16 parts of chrysanthemum and ginseng.The present invention combines traditional Chinese medical science integration of drinking and medicinal herbs theory, and selection function food carries out rational proportion, and the hypoglycemic and health food of reducing blood lipid of the invention is made.The health food of the present invention is integration of drinking and medicinal herbs food, is adapted to eat daily, makes the adjusted blood glucose of Impaired Glucose Regulation and fat metabolism, protection and improves organ function, improves the multiple benefits such as physical function.
Description
Technical field
The invention belongs to technical field of functional food, and in particular to a kind of hypoglycemic and the health food of reducing blood lipid and its life
Production method.
Background technology
With the acceleration of rapid economic development and process of industrialization, the acceleration of living-pattern preservation and aging process,
The illness rate of China's diabetes is in zooming trend, turns into another serious harm after cardiovascular and cerebrovascular disease, tumour
The important Chronic Non-Communicable Diseases of people's health.Estimate according to the World Health Organization, China is due to glycosuria between 2005 to 2015 years
Economic loss is up to 557,700,000,000 dollars caused by disease and related cardiovascular disease.And omnibus survey in recent years shows：It is either flourishing
Country or developing country, blood glucose control situation allow of no optimist.
According to IDF (IDF) count, global diabetic's number in 2011 up to 3.7 hundred million, wherein
80% in developing country, estimates that the year two thousand thirty whole world will have nearly 5.5 hundred million diabetic.The whole world shares 4,600,000 people within 2011
Diabetes are died from, the global medical of diabetes is spent up to 465,000,000,000 dollars then.2007 to 2008 years Chinese Medical Association's diabetes
Credit meeting (CDS) is shown in the Diabetes Epidemiological Investigation that China some areas are carried out, in the crowd more than 20 years old, glycosuria
Sick illness rate is 9.7%, and the ratio of prediabetes is 15.5%, only 40% is diagnosed in diabetic.2010
Diabetes prevalence survey report point out that national illness rate has increased to 11.6%.IGR (IGR) is glycometabolism
It is the preliminary stage of diabetes between the normally transition state between diabetes B.Effective intervention is carried out to IGR to be prevented
Only and delay the generation of diabetes, development, delay the complication of capilary and big blood vessel, so as to will substantially reduce the death of crowd
Rate.Diabetes belong to traditional Chinese medicine " diabete " category, and IGR then mutually should be early stage or the early stage of " diabete ".Therefore
For deficiency of both qi and yin, phlegm-blood stasis internal resistance, treating a disease by looking into both its root cause and symptoms is carried out, to reversing patient's condition, it is very crucial to improve insulin resistance.IGR crowd
In, complication such as high fat of blood also generally existing.Therefore high fat of blood is adjusted simultaneously, equally had for delaying IGR to develop into diabetes
It is significant.
Although at present it is believed that glycometabolism occurred slightly disorderly the IGR stage, but still it is not construed as one
Kind of disease, but a kind of sub-health state, if so using the method for the treatment of diabetes such as take Western medicine regulated and controled it is past
Toward that can exceed the proper limits in righting a wrong, the side effects such as hypoglycemia, gastrointestinal reaction are caused.
The content of the invention
In order to solve the above problems, the present invention provides a kind of health food and its producer for reducing blood glucose and reducing blood fat
Method, this health food combine traditional Chinese medicine and pharmacy theory, and selection function food carries out rational proportion, compositing formula.Formulations group
Compound is integration of drinking and medicinal herbs food, suitable for daily edible, make the adjusted blood glucose of Impaired Glucose Regulation and fat metabolism, protection and
Improve organ function, improve the multiple benefits such as physical function.
The technical scheme that the present invention solves above-mentioned technical problem is as follows：A kind of hypoglycemic and health food of reducing blood lipid, is pressed
Parts by weight meter, it is made up of following raw material：Mulberry leaf 2-5 parts, balsam pear 1-6 parts, chrysanthemum 1-6 parts and ginseng 1-3 parts.
On the basis of above-mentioned technical proposal, the present invention can also do following improvement.
Preferably, a kind of hypoglycemic and health food of reducing blood lipid, counts, is made up of following raw material in parts by weight：Mulberry leaf 4
Part, 4 parts of balsam pear, 1 part of chrysanthemum and 1 part of ginseng.
Preferably, a kind of hypoglycemic and the health food of reducing blood lipid, mulberry leaf and balsam pear are added by equivalent.
Preferably, a kind of hypoglycemic and the health food of reducing blood lipid, chrysanthemum and ginseng are added by equivalent.
The present invention also provides a kind of hypoglycemic and production method of the health food of reducing blood lipid, comprises the following steps：
Step 1：Based on raw material weight number, following raw material is taken：Mulberry leaf 2-5 parts, balsam pear 1-6 parts, chrysanthemum 1-6 parts and ginseng
1-3 parts.
Step 2：By mulberry leaf, balsam pear, chrysanthemum and ginseng mechanical crushing, 60 mesh sieves are crossed, obtain herb in granule form；
Step 3：The ethanol that volume fraction is 70%, the weight and medicine of ethanol are added in the herb in granule form obtained to step 2
Material weight ratio is 8:Ultrasonic 30min at 1,50 DEG C, filtering obtain extract solution, repeat extraction three times, merge extract solution；
Step 4：The extract solution that step 3 is obtained is evaporated under reduced pressure, control pressure 1000-10000Pa, and temperature is
50-55 DEG C, time 1-2h, alcohol extracting paste is obtained, be further dried in vacuo 1-2h under the conditions of 50 DEG C, produce hypoglycemic and drop
The health food of blood fat.
Preferably, a kind of hypoglycemic and health food of reducing blood lipid, health food add health food customary adjuvant and are made
Powdery or granular nutrient powder or tablet or capsule.
Mulberry leaf defend planning commission (the former Ministry of Public Health) by country always and include integration of drinking and medicinal herbs catalogue.The effect of mulberry leaf first recorded in《The legendary god of farming
Book on Chinese herbal medicine warp》, in the classic of TCM《Compendium of Materia Medica》In refer to more：It can only quench one's thirst, relieving the five internal organs, get round by bribery, lower gas can sharp size
Intestines, control labor heat cough, improving eyesight long hair etc..Mulberry leaf sweet-bitter flavor, cold nature, " mulberry leaf " is referred to as by Li Shizhen (1518-1593 A.D.), can informal dress, have
The good reputation of " ginseng is vulcanized, and mulberry leaf are mended clearly ".What Japanese eminent monk Rong Xi Buddhist monk edited and publish《Eat tea health note》Record, mulberry leaf have
The effect of improving " drinking-water disease " (i.e. diabetes).Crucial hypoglycemic activity composition in mulberry leaf is DNJ (DNJ-1), i.e.,
Belong to alpha-glucosidase inhibitor, there is the effect of significant regulating and controlling blood sugar, blood fat.
Balsam pear, bitter are cold in nature.The thoughts of returning home, spleen, lung channel.Heat, improving eyesight, removing toxic substances are washed in driving away summer heat.Hot summer weather polydipsia, quenches one's thirst, cute conjunctivitis pain
Bitterly, dysentery, sore and toxic.Contain a variety of alkaloids in the balsam pear of research discovery now, can be by number of ways to blood glucose and blood
Fat is adjusted.
Chrysanthemum, bitter, sweet, cold nature.Return lung, Liver Channel.Wind heat-clearing is dissipated, flat liver improving eyesight is clearing heat and detoxicating.Mulberry leaf and chrysanthemum are all
Can dispelling wind and heat from the body, suppressing liver-YANG, clear liver and improve vision, it is logical available control anemopyretic cold or warm disease from the beginning of, heating, micro- aversion to wind and cold, headache, liver
Positive rising, dizziness of having a headache, attack in wind-heat or liver-fire flaming caused by red eye, swell pain, and liver kidney asthenia of essence and blood, mesh is dark dim-sighted etc.
Card.But the power of mulberry leaf dispelling wind and heat from the body is stronger, and can clearing away the lungheat and moisturizing, cooling blood and hemostasis.Chrysanthemum soothing the liver, the power clear liver and improved vision are stronger, again
Can be clearing heat and detoxicating.Chrysanthemum is as conventional mulberry leaf compatibility material, integration of drinking and medicinal herbs, the effect of can strengthening mulberry leaf.
Ginseng, sweet, slight bitter are warm-natured, flat.Returns spleen, lung channel, the heart channel of Hang-Shaoyin.Tonifying Qi, prevent prolapse, promote the production of body fluid, calm the nerves, intelligence development.Big complement
Gas, veins takes off admittedly, reinforce the spleen to benefit the lung, promote the production of body fluid, calm the nerves.Cure mainly it is physically weak to be taken off, cold weak pulse of limb, spleen eating less, the deficiency syndrome of the lung breathes with cough, Tianjin wound
Yearningly, Heat Diabetes, prolonged illness void is thin, insomnia of palpitating with fear, impotence Gong Leng；Heart failure, cardiogenic shock.For dyspnea with shortness of breath, palpitaition
Forgetful, thirsty hidrosis, deficiency of food is powerless, all acute and chronic diseases and caused shock, collapse after losing blood.Reinforce vital energy, prevent prolapse life
Tianjin, calm the nerves.It is deficient to control internal lesion caused by overexertion, deficiency of food, burnout, regurgitation and emesis, lingering diarrhea of defecating, cough of deficient and syndrome characterized by dyspnea, spontaneous perspiration sudden collapse, palpitation with fear is forgetful, dizzy
Dizzy headache, impotence, frequent micturition, quenches one's thirst, woman uterine bleeding, infantile chronic fright, and perennial and irrecoverable weakness, the card of all qi-blood-body fluid deficiencies.Ginseng
Number is vulcanized, and mulberry leaf number is mended clearly, and both can balance help at cooperation, and eubolism balance is maintained while regulating and controlling blood sugar blood fat.
Compared with prior art, the beneficial effects of the invention are as follows：
The present invention combines traditional Chinese medical science integration of drinking and medicinal herbs theory, and selection function food carries out rational proportion, and present invention drop blood is made
Sugar and the health food of reducing blood lipid.The health food of the present invention is integration of drinking and medicinal herbs food, is adapted to eat daily, makes IGR
The adjusted blood glucose of patient and fat metabolism, protection and raising organ function, improve the multiple benefits such as physical function.
Embodiment
The principles and features of the present invention are described below, and the given examples are served only to explain the present invention, is not intended to limit
Determine the scope of the present invention.
Embodiment 1
Step 1：Based on raw material weight number, following raw material is taken：Mulberry leaf 400g, dried Frutus Momordicae Charantiae 400g, chrysanthemum 100g and ginseng
100g。
Step 2：By mulberry leaf, balsam pear, chrysanthemum and ginseng mechanical crushing, 60 mesh sieves are crossed, obtain herb in granule form 0.8kg；
Step 3：6.4kg volume fractions are added in the herb in granule form obtained to step 2 as 70% ethanol, ultrasound at 50 DEG C
30min, filtering obtain extract solution, so repeat extraction three times, merge extract solution；
Step 4：The extract solution that step 3 is obtained is evaporated under reduced pressure, control pressure 10000Pa, and temperature is 55 DEG C, when
Between be 1h, obtain alcohol extracting paste, be further dried in vacuo 1h under the conditions of 50 DEG C, produce the hypoglycemic and health care of reducing blood lipid food
Product.
Embodiment 2
Step 1：Based on raw material weight number, following raw material is taken：Mulberry leaf 300g, dried Frutus Momordicae Charantiae 300g, chrysanthemum 200g and ginseng
200g。
Step 2：By mulberry leaf, balsam pear, chrysanthemum and ginseng mechanical crushing, 60 mesh sieves are crossed, obtain herb in granule form 0.8kg；
Step 3：6.4kg volume fractions are added in the herb in granule form obtained to step 2 as 70% ethanol, ultrasound at 50 DEG C
30min, filtering obtain extract solution, so repeat extraction three times, merge extract solution；
Step 4：The extract solution that step 3 is obtained is evaporated under reduced pressure, control pressure 1000Pa, and temperature is 50 DEG C, when
Between be 2h, obtain alcohol extracting paste, be further dried in vacuo 2h under the conditions of 50 DEG C, produce the hypoglycemic and health care of reducing blood lipid food
Product.
The Combined food that above-described embodiment 1 is prepared to gained carries out following pharmacodynamic experiment：
The embodiment of the present invention 1 is prepared into the Combined food alcohol extracting thing dried powder of gained to the high fructose diet induced of high fat
IGR mouse model carry out the experiment of hypoglycemic and effect for reducing blood fat：
1. experiment material and method
Experimental animal：SPF level ICR mouse, 20-22g, male, Shanghai Jie Sijie experimental animals Co., Ltd provide.Mouse
Feed ingredient：Carbohydrate 64%, protein 21%, fat 4%, fiber 5%, it is limited to be purchased from Shanghai Jie Sijie experimental animals
Company.Mouse feeder is in Laboratory Animal Science portion of Medical College, Shanghai Communication Univ. (SPF levels).Room ventilation condition is good, normally
Day-night change, relative humidity are 55 ± 5%, room temperature：23±2℃.
Experimental method：After mouse adaptability is fed 7 days, 50 mouse are randomly divided into 5 groups, every group 10, make following point
Group：Normal group (NC), the Tween-80 solution of gavage 7%；Model control group (MC), with 15% fruit while gavage Fat Emulsion
Syrup is as unique water source；Melbine positive controls (PC)；The embodiment of the present invention 1 prepares the food compositions alcohol extracting of gained
Thing middle dose group (MF) and high dose group (HF).The edible conventional feed of each group, NC group drinking pure waters；In addition to NC groups, remaining
The equal gavage Fat Emulsion of each group, unique water source is used as using 15% fructose water.Fat Emulsion preparation method：Lard 50g, cholesterol 1.5g,
Pig cholate 0.3g, Tween-80 7mL, adds water to be settled to 100mL, is made into Fat Emulsion, -20 DEG C of preservations.
Daily given low (in)=amount ÷ body weight (in terms of 60kg) × the weight of animals × 20 times formula (1)
Daily given low (height)=amount ÷ body weight (in terms of 60kg) × the weight of animals × 30 times formula (2)
The gavage amount of the alcohol extracting thing of formula is calculated with formula (1) and (2), is then diluted with distilled water into mouse
Adapt to gavage volume (0.2mL/10g b.w), positive controls gavage 0.5g/kg melbine.
2. measure and observation index
After adaptation raising terminates, each group is grouped more than and carries out intervention experiment, continuous gavage 10 weeks, is weighed within every three days
1 time, satellite recanalization dosage.Test the 12nd weekend measure sugar tolerance, experiment the 10th weekend measure insulin tolerance.Experiment knot
Shu Shi, fasting 13h after animal administration, unlimited drinking-water, eyeball blood sampling is plucked, determines TC, TG, HDL-C, LDL-C and FFA content.
2.1. the measure of blood glucose
Mouse fasting (can't help water) 13h, cuts tail vein blood, with Johnson ＆ Johnson's blood glucose meter measure mouse blood sugar, directly reads number
According to.
2.2. oral glucose tolerance experiment (OGTT)
Mouse fasting (can't help water) 13h, each group its mouse oral give 2.0g/kg b.w. glucose solutions.Subsequent
In 120min, tail vein blood, blood glucose meter measure blood glucose are cut in 0min, 30min, 60min, 120min respectively.Glucose tolerance curve
Lower area (AUC) is calculated using trapezoidal method：
TG-AUC=0.25 × (0min blood glucose+30min blood glucose)+0.25 × (30min blood glucose+60min blood glucose)+
0.5 × (60min blood glucose+120min blood glucose)
2.3. insulin tolerance test (ITT)
Mouse fasting (can't help water) 4h, each group mouse peritoneal injection 0.6IU/kg b.w. short-acting insulins.Subsequent
In 90min, tail vein blood, blood glucose meter measure blood glucose are cut in 0min, 30min, 50min, 70min, 90min respectively.
2.4. the measure of blood fat
Mouse fasting (can't help water) 13h, taken a blood sample in eyeball rear vein beard, 15min is centrifuged in 4000g, separate serum, measure
TC, TG, LDL-C, HDL-C and FFA.
3. experimental result：
The IGR mouse of Fat Emulsion joint fructose induction are intervened, the sugar tolerance result after 12 weeks is as shown in table 1.
The sugar tolerance (n=20) of mouse after table 1. is intervened 12 weeks
Note：Compared with NC, #P<0.05, ##P<0.01；Compared with MC, * P<0.05, * * P<0.01.
From table 1, model control group shows joint IGT after 12 weeks in diet induced, and fasting blood-glucose ratio is just
Normal control group rise 19.3%, has pole significant difference, its AUC has pole significant difference compared with Normal group.Melbine
Make the fasting blood-glucose of mouse reduce, improve sugar tolerance, it is persistently effective to illustrate that antidiabetic drug is shown to mouse IGR
Preventive effect.Relatively there were significant differences with model control group for the alcohol extract high dose group each point blood glucose and AUC of formula, drops respectively
Low 22.2%, 8.9%, 10.9%, 15.9% and 11.0%, its middle dose group mouse fasting blood-glucose, 120min blood glucose and AUC drops
It is low, more there is pole significant difference with model control group.Compare gavage and match somebody with somebody intervention result of the formula extraction to mouse IGR after 12 weeks
It was found that：The alcohol extract high dose of formula reduces fasting blood-glucose while improving IGT, lasting to mouse IGR preventive effect, in amount
Effect relation.
IGR mouse are intervened the 10th week with formula extraction and carry out ITT, the results are shown in Table 2：
The insulin tolerance (n=10) of mouse after table 2. is intervened 10 weeks
Note：Compared with NC, ##P<0.01；Compared with MC, * P<0.05, * * P<0.01.
From table 2, blood glucose declines after model control group mouse peritoneal injection insulin, and blood glucose reaches minimum during 50min
Point, subsequent blood glucose bottom out, blood glucose reaches the 64.0% of initial blood glucose during 90min, and initial blood glucose compares respectively with 90min blood glucose
Normal group mouse high 54.2% and 69.0%, there is pole significant difference.Positive controls initial blood glucose is distinguished with 90min blood glucose
Decline 21.6% and 28.2% than model control group, there were significant differences.It is less than model pair with formula extraction intervention group initial blood glucose
According to group, and there is significant difference；Alcohol extract high dose group 50min, 70min and 90min blood glucose of formula is below model comparison
Group (P<0.05), 90min blood glucose only reaches the 33.3% of initial blood glucose；It is formulated alcohol extract middle dose group 50min blood glucose and model
Control group does not have difference, it is seen that and for formula alcohol extract in the effect for improving mouse islets element sensitiveness, high dose is better than middle dosage,
Dose-effect relationship be present.
IGR mouse are intervened the 10th week with formula extraction and carry out carry out lipid determination, the results are shown in Table 3.
The blood lipids index (n=20) of mouse after table 3. is intervened 10 weeks
| NC | MC | PC | MF | HF | |
| LDL-C(mM) | 0.27±0.08 | 0.39±0.12## | 0.54±0.10 | 0.37±0.04 | 0.38±0.09 |
| HDL-C(mM) | 4.15±0.86 | 4.97±1.02 | 4.77±1.35 | 3.88±0.74* | 3.76±0.89* |
| TC(mM) | 5.56±1.05 | 10.87±1.79## | 12.93±1.76 | 9.76±1.98* | 8.56±1.80** |
| TG(mM) | 1.33±0.43 | 1.45±0.87 | 1.27±0.39 | 1.33±0.50 | 1.24±0.30* |
| FFA(mM) | 0.52±0.13 | 0.77±0.27# | 0.52±0.13 | 0.48±0.18* | 0.44±0.17** |
Note：Compared with NC, ##P<0.01；Compared with MC, * P<0.05, * * P<0.01.
After model control group diet induced 10 weeks, mice serum LDL-C, TC and FFA level is significantly higher than Normal group.
Melbine makes serum LDL-C and TC contents have elevated trend.Being formulated alcohol extract middle dosage reduces FFA levels, high dose group
It is horizontal to reduce TC, TG and FFA.
Result is visible from the above mentioned, and this health-care food of the invention can play reduces blood glucose well, drops simultaneously
The effect of low blood fat.
Claims (6)
1. a kind of hypoglycemic and health food of reducing blood lipid, it is characterised in that count, be made up of following raw material in parts by weight：Mulberry
Leaf 2-5 parts, balsam pear 1-6 parts, chrysanthemum 1-6 parts and ginseng 1-3 parts.
2. a kind of hypoglycemic and health food of reducing blood lipid according to claim 1, it is characterised in that in parts by weight
Meter, is made up of following raw material：1 part of 4 parts of mulberry leaf, 4 parts of balsam pear, 1 part of chrysanthemum and ginseng.
3. a kind of hypoglycemic and health food of reducing blood lipid according to claim 1, it is characterised in that：Described mulberry leaf and
Balsam pear is added by equivalent.
4. a kind of hypoglycemic and health food of reducing blood lipid according to claim 1, it is characterised in that：Described chrysanthemum and
Ginseng is added by equivalent.
5. a kind of hypoglycemic and production method of the health food of reducing blood lipid, it is characterised in that comprise the following steps：
Step 1：Based on raw material weight number, following raw material is taken：Mulberry leaf 2-5 parts, balsam pear 1-6 parts, chrysanthemum 1-6 parts and ginseng 1-3
Part；
Step 2：By mulberry leaf, balsam pear, chrysanthemum and ginseng mechanical crushing, 60 mesh sieves are crossed, obtain herb in granule form；
Step 3：The ethanol that volume fraction is 70%, weight and the medicinal material weight of ethanol are added in the herb in granule form obtained to step 2
The ratio between amount is 8:Ultrasonic 30min at 1,50 DEG C, filtering obtain extract solution, repeat extraction three times, merge extract solution；
Step 4：The extract solution that step 3 is obtained is evaporated under reduced pressure, control pressure 1000-10000Pa, temperature 50-55
DEG C, time 1-2h, alcohol extracting paste is obtained, be further dried in vacuo 1-2h under the conditions of 50 DEG C, produce hypoglycemic and reducing blood lipid
Health food.
6. a kind of hypoglycemic and health food of reducing blood lipid according to claim 1, it is characterised in that：The health food
Add health food customary adjuvant and powdery or granular nutrient powder or tablet or capsule is made.
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| CN110558401A (en) * | 2019-10-11 | 2019-12-13 | 安徽农业大学 | Compound tea and application thereof in preparing food and health-care product for preventing metabolic syndrome |
| CN114712481A (en) * | 2022-04-13 | 2022-07-08 | 河南城建学院 | Composite plant source polypeptide and preparation method and application thereof |
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| CN110558401A (en) * | 2019-10-11 | 2019-12-13 | 安徽农业大学 | Compound tea and application thereof in preparing food and health-care product for preventing metabolic syndrome |
| CN110558401B (en) * | 2019-10-11 | 2023-06-06 | 安徽农业大学 | Composite tea and application thereof in preparation of food and health care products for preventing metabolic syndrome |
| CN114712481A (en) * | 2022-04-13 | 2022-07-08 | 河南城建学院 | Composite plant source polypeptide and preparation method and application thereof |
| CN114712481B (en) * | 2022-04-13 | 2024-03-01 | 河南城建学院 | Composite plant source polypeptide and preparation method and application thereof |
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Application publication date: 20180126 |
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