CN1698871A - Health product for assisting blood sugar-decreasing function and its preparation method - Google Patents
Health product for assisting blood sugar-decreasing function and its preparation method Download PDFInfo
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- CN1698871A CN1698871A CN 200510071100 CN200510071100A CN1698871A CN 1698871 A CN1698871 A CN 1698871A CN 200510071100 CN200510071100 CN 200510071100 CN 200510071100 A CN200510071100 A CN 200510071100A CN 1698871 A CN1698871 A CN 1698871A
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- health food
- poria
- momordicae charantiae
- rhizoma dioscoreae
- folium mori
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Abstract
The invention provides a health product for assisting blood sugar-decreasing function and its preparation method, wherein the health food is prepared from ginseng, Poria cocos, rhizoma dioscoreae, mulberry leaf, bitter gourd, and can be made into the forms of oral capsule, tablet and granule.
Description
Technical field
The invention belongs to field of health care food, the invention provides health food of a kind of auxiliary hyperglycemic and preparation method thereof.
Background technology
Diabetes are the one group of Developmental and Metabolic Disorder syndromes that is caused by the h and E factor interaction.Because of there are defective simultaneously in insulin secretion, insulin action or both, cause the metabolism disorder of carbohydrate, protein, fat, power and water Xie Zhi etc., clinical is main common trait with long-term hyperglycemia.Long-term diabetes can cause the chronic complicating diseases of a plurality of systems organ, cause dysfunction and depletion, become disable, lethal main cause.At present, the number of patients of diabetes increases sharply, and global according to statistics diabetics is about 1.32 hundred million, and there is 2000-3000 ten thousand more than in China.Because the cause of disease and the pathogenesis of diabetes are not clear fully as yet, therefore also lack effective etiological treatment method at present.Clinically treatment of diabetes is adopted insulinize and oral hypoglycemic drug therapy more now, yet diabetes spp is in a kind of lifelong participation disease, need long-term prescription, the drug administration by injection method of insulin tends to bring many inconvenience to the patient, and clinical orally-taken blood sugar reducing medicine commonly used belongs to chemical drugs or biologics more, takes for a long time also and can cause a series of untoward reaction.In view of there being above problem, so a kind of hypoglycemia healthcare food safe, effective, that be suitable for taking for a long time of exploitation is badly in need of on present Medicines and Health Product market very much.
Health food of the present invention very meets the present market demand because of possessing following characteristics: 1. blood sugar decreasing effect is very clear and definite, and pharmacological evaluation proves that the hypoglycemic activity of this health food is more outstanding, only slightly is weaker than the positive drug metformin; 2. all raw materials do not contain any nourishing additive agent all from natural medicinal plant, and raw material is the Chinese crude drug of integration of edible and medicinal herbs, take safety, reliable for a long time; 3. this health food is a peroral dosage form, is easy to carry and takes; 4. very rare with the similar Related product of this health food in the market.
Summary of the invention
The object of the present invention is to provide health food of a kind of auxiliary hyperglycemic and preparation method thereof.
The health food of auxiliary hyperglycemic of the present invention is that the feedstock production by following weight parts forms:
Radix Ginseng 5-30 Poria 50-200
Rhizoma Dioscoreae 100-300 Folium Mori 50-200
Fructus Momordicae charantiae 150-450
The weight ratio of above-mentioned raw materials is preferred:
Radix Ginseng 5 Poria 60
Rhizoma Dioscoreae 120 Folium Mori 60
Fructus Momordicae charantiae 200
The weight ratio of above-mentioned raw materials is also preferred:
Radix Ginseng 6 Poria 90
Rhizoma Dioscoreae 150 Folium Mori 90
Fructus Momordicae charantiae 300
The weight ratio of above-mentioned raw materials is also preferred:
Radix Ginseng 10 Poria 120
Rhizoma Dioscoreae 200 Folium Mori 120
Fructus Momordicae charantiae 350
The weight ratio of above-mentioned raw materials is also preferred:
Radix Ginseng 25 Poria 160
Rhizoma Dioscoreae 250 Folium Mori 160
Fructus Momordicae charantiae 400
Health food of the present invention can be the health food dosage form of any routine.Preferred capsule, tablet, granule.
Capsule of the present invention can be prepared from by the following method:
1) takes by weighing that Poria, Rhizoma Dioscoreae mix with the Folium Mori medical material, adds 5-12 times of water gaging behind the water rinse, drying, pulverizing by formula ratio, soak after 0.5-2 hour, decocted 0.5-3 hour, medicinal liquid filters, filtrate for later use, under the same conditions medicinal residues are repeated to decoct 1-3 time, merging filtrate is evaporated to behind the small size standby;
2) carry out coarse powder after getting ginseng crude drug's water rinse, drying, the coarse powder granule of gained is put into super micron mill carry out micronizing, the gained ultra-micro powder is crossed behind the 80-500 mesh sieve standby;
3) squeeze the juice after getting fresh Fructus Momordicae charantiae water rinse, institute's squeezeding juice supernatant utilization after centrifugal molecular weight that dams carries out ultrafiltration for the ultrafilter membrane of 500-10000, and it is standby that the gained filtering residue gets the Succus Momordicae charantiae lyophilized powder through lyophilization; Gained filtrate and above-mentioned Poria, Rhizoma Dioscoreae and Folium Mori medicinal substances extract concentrated solution carry out spray drying after merging, and it is standby to get spray-dried powders;
4) above spray-dried powders, Succus Momordicae charantiae lyophilized powder, Radix Ginseng ultra-micro powder are pressed formula ratio and mixed, abundant mixing in blender, the 8-40 mesh sieve is crossed in the back of granulating, drying, with 8-40 mesh sieve granulate, the back filled capsules of sterilizing, packing promptly gets the agent of this health-care edible capsule.
The preparation method of tablet of the present invention and granule is: step is with above-mentioned 1), 2), 3) step, the 4th) step undertaken by the method for preparing tablet and granule of this area routine, make tablet of the present invention and granule.
Embodiment 1
Radix Ginseng 5 Poria 60
Rhizoma Dioscoreae 120 Folium Mori 60
Fructus Momordicae charantiae 200
Preparation method is as follows:
1) takes by weighing that Poria, Rhizoma Dioscoreae mix with the Folium Mori medical material, adds 7 times of water gagings behind the water rinse, drying, pulverizing by formula ratio, soak after 1 hour, decocted 1 hour, medicinal liquid filters, and filtrate for later use repeats medicinal residues to decoct 2 times under the same conditions, merging filtrate is evaporated to behind the small size standby;
2) carry out coarse powder after getting ginseng crude drug's water rinse, drying, the coarse powder granule of gained is put into super micron mill carry out micronizing, the gained ultra-micro powder is crossed behind 300 mesh sieves standby;
3) squeeze the juice after getting fresh Fructus Momordicae charantiae water rinse, institute's squeezeding juice supernatant utilization after centrifugal molecular weight that dams is that 1000 ultrafilter membrane carries out ultrafiltration, and it is standby that the gained filtering residue gets the Succus Momordicae charantiae lyophilized powder through lyophilization; Gained filtrate and above-mentioned Poria, Rhizoma Dioscoreae and Folium Mori medicinal substances extract concentrated solution carry out spray drying after merging, and it is standby to get spray-dried powders;
4) above spray-dried powders, Succus Momordicae charantiae lyophilized powder, Radix Ginseng ultra-micro powder are pressed formula ratio and mixed, abundant mixing in blender, 12 mesh sieves are crossed in the back of granulating, drying, with 14 mesh sieve granulate, filled capsules after the sterilization, packing promptly gets the agent of this health-care edible capsule.
Embodiment 2
The weight ratio of above-mentioned raw materials is also preferred:
Radix Ginseng 6 Poria 90
Rhizoma Dioscoreae 150 Folium Mori 90
Fructus Momordicae charantiae 300
Preparation method is with embodiment 1.
Embodiment 3
The weight ratio of above-mentioned raw materials is also preferred:
Radix Ginseng 10 Poria 120
Rhizoma Dioscoreae 200 Folium Mori 120
Fructus Momordicae charantiae 350
Preparation method is:
Step 1), 2) and 3) with embodiment 1, the 4) step carry out according to the method for preparing tablet of this area routine, make tablet of the present invention.
Embodiment 4
The weight ratio of above-mentioned raw materials is also preferred:
Radix Ginseng 25 Poria 160
Rhizoma Dioscoreae 250 Folium Mori 160
Fructus Momordicae charantiae 400
Preparation method is:
Step 1), 2) and 3) with embodiment 1, the 4) step carry out according to the method for preparing granule of this area routine, make granule of the present invention.
The pharmacodynamics data
Pharmacodynamic experiment studies show that health food of the present invention has good hypoglycemic activity, mainly shows: give mouse stomach with large and small two dosage respectively, successive administration 10 days is observed the influence of this health food to the blood glucose in diabetic mice level.The result shows: compare with model group, all can obviously reduce the blood sugar level of diabetic mice after large and small two dosage groups of this health food suspension and the treatment of positive drug metformin group, its blood glucose rate of descent is respectively 39.97%, 43.09%, 50.98%, all has significant difference.Illustrate that this health food under large and small dosage effect, all has the obvious functions of blood sugar effect, its hypoglycemic activity slightly is weaker than the positive drug metformin.
1. experiment purpose
Observe of the influence of safe capsule to the blood glucose in diabetic mice level.
2. experiment material
2.1 medicine
2.1.1 be subjected to the reagent thing
Title: safe capsule
Character: brown solid granule
Compound method: being mixed with concentration respectively with water is 15.0mg/mL, the suspension of 44.2mg/mL.
2.1.2 positive drug
Title: metformin hydrochloride tablet (Metformin Hydrochloride Tablets)
Character: white tablet
Produce: Kunshan Shuanghe Pharmaceutical Co., Ltd.
Lot number: 0408152
Compound method: it is the 25.0mg/mL suspension that grind into powder is mixed with concentration with water
2.1.3 modeling agent
Title: streptozotocin (streptozocin, STZ)
Character: white powder
Produce: Sigma company
Compound method: with 0.1mol/L, it is 13.5mg/mL solution that the pH=4.4 citrate buffer is mixed with concentration.
2.2 animal
Source: ICR mice (laboratory animal portion in Department Of Medicine, Peking University's provides)
The quality certification number: SCXK11-00-0004 meets one-level laboratory animal standard
Body weight: 18-22g
Sex: male
Number of animals: 60
3. experimental technique
3.1 modeling method
After the mice fasting 12 hours, intraperitoneal injection streptozotocin (135mg/kg) is set up the diabetic mice model.From mouse orbit rear vein beard measuring blood sugar of blood extracting concentration, blood sugar concentration is higher than normal group twice person and is diabetic mice after two weeks of modeling.
3.2 medication
60 mices are divided into 6 groups at random: the normal control group (is not injected the modeling agent, irritate stomach with water), model control group (injection modeling agent, irritate stomach with water), metformin group (injection modeling agent is with the metformin suspension oral gavage) is big, small dose group (after the injection modeling agent) with safe capsule suspension oral gavage.
Route of administration: oral administration gavage administration.
Administering mode and dosage: small dose group: the 150m/kg body weight, heavy dose of group: the 442mg/kg body weight all by the administration of 0.1mL/10g body weight, after weighing in early morning every day, once gives safe capsule suspension.Positive drug group: press the 125mg/kg body weight, after weighing sooner or later every day, give the metformin suspension respectively, the 0.1mL/10g body weight.
Successive administration 10 days writes down body weight early morning every day, observes mice dietary amount, amount of drinking water and urine quantitative changeization, and last administration 2h posterior orbit rear vein beard is got blood and surveyed blood glucose.
4. experimental result
Compare the positive drug metformin with model group and have remarkable hypoglycemic activity, heavy dose of group of capsule and small dose group also have remarkable hypoglycemic activity safely, but slightly are weaker than metformin.
Table 1 medicine is to the mouse blood sugar level affects
| Grouping | ????n | Dosage (mg/10g) | Blood glucose (mmol/L) | Blood glucose difference (mmol/L) | Decline percentage rate (%) |
| Normal group | ????10 | ?5.10±1.07 | |||
| Model group | ????10 | ?13.49±6.35 | ????2.28 | ????33.44 | |
| The metformin group | ????10 | ????2.50 | ?4.93±1.99*** | ????-5.44** | ????-50.98** |
| Heavy dose of group | ????10 | ????4.42 | ?6.65±3.90** | ????-5.62* | ????-39.97* |
| Small dose group | ????8 | ????1.50 | ?5.80±3.24** | ????-4.84* | ????-43.09* |
* compare P＜0.05 with the model group analog value; * and model group analog value be P＜0.01 relatively;
* * and model group analog value be P＜0.001 relatively
Body weight change (g) in the table 2 modeling process
| Natural law | 0 | ?2 | ?4 | ?6 | 8 | ?10 | ?12 | ?14 | ?16 |
| Normally | 21.31 | ?23.45 | ?25.12 | ?26.75 | 28.62 | ?29.86 | ?30.76 | ?31.78 | ?32.84 |
| Model | 20.25 | ?22.20 | ?23.79 | ?25.78 | 26.15 | ?27.41 | ?28.15 | ?28.53 | ?28.68 |
Body weight change (g) in the table 3 administration process
| 1 | ?2 | ?3 | ?4 | ?5 | ?6 | ?7 | ?8 | 9 | 10 | |
| Normally | 31.61 | ?31.78 | ?32.41 | ?31.97 | ?32.26 | ?32.82 | ?33.24 | ?32.70 | 32.96 | 33.07 |
| Model | 26.48 | ?27.05 | ?27.56 | ?27.65 | ?27.43 | ?27.49 | ?27.37 | ?27.17 | 26.73 | 24.92 |
| Positive | 27.02 | ?28.46 | ?28.54 | ?28.46 | ?27.75 | ?27.89 | ?28.03 | ?28.45 | 28.32 | 25.01 |
| Heavy dose of | 26.57 | ?27.45 | ?27.47 | ?27.40 | ?27.13 | ?27.04 | ?26.58 | ?26.41 | 26.35 | 23.85 |
| Low dose of | 28.35 | ?27.46 | ?27.17 | ?27.38 | ?26.84 | ?26.25 | ?25.03 | ?24.85 | 24.99 | 22.96 |
5. discuss
As can be seen from Table 2, modeling group body weight gain after modeling is obviously slack-off than normal group, and this is one of diabetes classical symptom.Other symptoms are performance to some extent also: the modeling group increases occurring amount of drinking water, dietary amount and urine amount after three days for the modeling agent, and the urine amount increases obviously during all left and right sides.These symptoms show model initial success.After two weeks, survey blood glucose, choose modeling group blood glucose value and be higher than normal group twice person and be model.
By table 1 as seen, compare with model group, all can obviously reduce the blood sugar level of diabetic mice safely after the treatment of the large and small dosage group of capsule suspension and metformin group, its blood glucose rate of descent is respectively 39.97%, 43.09%, 50.98%, all has significant difference, the above two P＜0.05, latter P＜0.01.Safe capsular hypoglycemic activity is compared slightly with the effect of positive drug metformin a little less than.
Table 3 shows, the body weight change during the administration, and except that the normal group body weight rose to some extent, other groups the weight loss phenomenon all occurred at predrug period, and afterwards, positive drug group body weight is gone up to some extent, and the large and small dosage group of capsule suspension mice weight loss is alleviated safely.
6. conclusion
Mouse stomach gives safe capsule suspension dosage 150mg/kg body weight, the 442mg/kg body weight has remarkable hypoglycemic activity, but slightly is weaker than metformin (250mg/kg).
Claims (7)
1, a kind of health food of auxiliary hyperglycemic is characterized in that it is that feedstock production by following weight parts forms:
Radix Ginseng 5-30 Poria 50-200
Rhizoma Dioscoreae 100-300 Folium Mori 50-200
Fructus Momordicae charantiae 150-450.
2, health food as claimed in claim 1 is characterized in that the weight ratio of raw material is:
Radix Ginseng 5 Poria 60
Rhizoma Dioscoreae 120 Folium Mori 60
Fructus Momordicae charantiae 200.
3, health food as claimed in claim 1 is characterized in that the weight ratio of raw material is:
Radix Ginseng 6 Poria 90
Rhizoma Dioscoreae 150 Folium Mori 90
Fructus Momordicae charantiae 300.
4, health food as claimed in claim 1 is characterized in that the weight ratio of raw material is:
Radix Ginseng 10 Poria 120
Rhizoma Dioscoreae 200 Folium Mori 120
Fructus Momordicae charantiae 350.
5, health food as claimed in claim 1 is characterized in that the weight ratio of raw material is:
Radix Ginseng 25 Poria 160
Rhizoma Dioscoreae 250 Folium Mori 160
Fructus Momordicae charantiae 400.
6,, it is characterized in that this health food is capsule, tablet or granule as the arbitrary described health food of claim 1-5.
7, the preparation method of the described health food of claim 6 is characterized in that may further comprise the steps:
1) takes by weighing that Poria, Rhizoma Dioscoreae mix with the Folium Mori medical material, adds 5-12 times of water gaging behind the water rinse, drying, pulverizing by formula ratio, soak after 0.5-2 hour, decocted 0.5-3 hour, medicinal liquid filters, filtrate for later use, under the same conditions medicinal residues are repeated to decoct 1-3 time, merging filtrate is evaporated to behind the small size standby;
2) carry out coarse powder after getting ginseng crude drug's water rinse, drying, the coarse powder granule of gained is put into super micron mill carry out micronizing, the gained ultra-micro powder is crossed behind the 80-500 mesh sieve standby;
3) squeeze the juice after getting fresh Fructus Momordicae charantiae water rinse, institute's squeezeding juice supernatant utilization after centrifugal molecular weight that dams carries out ultrafiltration for the ultrafilter membrane of 500-10000, and it is standby that the gained filtering residue gets the Succus Momordicae charantiae lyophilized powder through lyophilization; Gained filtrate and above-mentioned Poria, Rhizoma Dioscoreae and Folium Mori medicinal substances extract concentrated solution carry out spray drying after merging, and it is standby to get spray-dried powders;
4) above spray-dried powders, Succus Momordicae charantiae lyophilized powder, Radix Ginseng ultra-micro powder are pressed formula ratio and mixed, abundant mixing in blender, the 8-40 mesh sieve is crossed in the back of granulating, drying, with 8-40 mesh sieve granulate, the back filled capsules of sterilizing, packing promptly gets the agent of this health-care edible capsule.
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| CN102293817A (en) * | 2011-08-29 | 2011-12-28 | 湖北康进药业有限责任公司 | Traditional Chinese medicine composition for reducing blood sugar and preparation method thereof |
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| CN104522572A (en) * | 2014-12-05 | 2015-04-22 | 安徽金龙山葛业有限公司 | Radix puerariae powder capable of supplementing qi and benefit spleen |
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| CN106722918A (en) * | 2015-11-25 | 2017-05-31 | 北京华昱安然医药科技有限公司 | A kind of hypoglycemia healthcare food and preparation method thereof |
| CN107319540A (en) * | 2017-08-18 | 2017-11-07 | 青岛瑞思德生物科技有限公司 | A kind of health food for improving diabetes containing Enteromorpha and preparation method thereof |
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| CN102293817A (en) * | 2011-08-29 | 2011-12-28 | 湖北康进药业有限责任公司 | Traditional Chinese medicine composition for reducing blood sugar and preparation method thereof |
| CN102511812A (en) * | 2011-12-31 | 2012-06-27 | 大连三禾生物有限公司 | Food for lowering blood-sugar level in diabetes mellitus type 2 and production method of food |
| CN102763884A (en) * | 2012-07-23 | 2012-11-07 | 广西金赛保健品有限责任公司 | Health-care beverage of guava and making method of health-care beverage |
| CN104522573A (en) * | 2014-12-05 | 2015-04-22 | 安徽金龙山葛业有限公司 | Radix puerariae powder capable of harmonizing stomach for descending adverse qi |
| CN104522572A (en) * | 2014-12-05 | 2015-04-22 | 安徽金龙山葛业有限公司 | Radix puerariae powder capable of supplementing qi and benefit spleen |
| CN106722918A (en) * | 2015-11-25 | 2017-05-31 | 北京华昱安然医药科技有限公司 | A kind of hypoglycemia healthcare food and preparation method thereof |
| CN105410623A (en) * | 2015-11-30 | 2016-03-23 | 谢晓亮 | Reinforced buckwheat instant paste and preparation method thereof |
| CN105410623B (en) * | 2015-11-30 | 2019-03-19 | 河北康平健康产业有限责任公司 | A kind of reinforcing buckwheat fast food paste and preparation method thereof |
| CN107319540A (en) * | 2017-08-18 | 2017-11-07 | 青岛瑞思德生物科技有限公司 | A kind of health food for improving diabetes containing Enteromorpha and preparation method thereof |
| CN107625129A (en) * | 2017-09-06 | 2018-01-26 | 如皋市滋生堂生物科技有限公司 | A kind of hypoglycemic and the health food and its production method of reducing blood lipid |
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| CN112274610A (en) * | 2020-12-14 | 2021-01-29 | 姚忠泽 | A Chinese medicinal granule with medicinal and edible effects for lowering blood sugar, and its preparation method |
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