CN108704052A - Hypoglycemic papaya hardship mulberry tablet or capsule and its preparation process - Google Patents

Hypoglycemic papaya hardship mulberry tablet or capsule and its preparation process Download PDF

Info

Publication number
CN108704052A
CN108704052A CN201810945894.XA CN201810945894A CN108704052A CN 108704052 A CN108704052 A CN 108704052A CN 201810945894 A CN201810945894 A CN 201810945894A CN 108704052 A CN108704052 A CN 108704052A
Authority
CN
China
Prior art keywords
papaya
mulberry
hardship
capsule
hypoglycemic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810945894.XA
Other languages
Chinese (zh)
Inventor
孙今雄
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shide (guangzhou) Health Technology Co Ltd
Original Assignee
Shide (guangzhou) Health Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shide (guangzhou) Health Technology Co Ltd filed Critical Shide (guangzhou) Health Technology Co Ltd
Priority to CN201810945894.XA priority Critical patent/CN108704052A/en
Publication of CN108704052A publication Critical patent/CN108704052A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/346—Platycodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/738—Rosa (rose)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of hypoglycemic papaya hardship mulberry tablet or capsule, the hypoglycemic papaya hardship mulberry tablet or capsule include that papaya hardship mulberry composition, dextrin are prepared, and papaya hardship mulberry composition includes following weight parts raw material：5-10 parts of papaya, 1-5 parts of balsam pear, 2-6 parts of mulberry leaf, 3-7 parts of campanulaceae, 3-7 parts of Chinese yam.The hypoglycemic papaya hardship mulberry tablet or capsule of the present invention, the balsam pear contained, mulberry leaf, campanulaceae, Chinese yam and papaya can promote microcirculation, increase tissue support, on repair cell film insulin receptor effect, restore sensibility of the receptor to insulin.Pancreas islet chronic inflammation can also be eliminated, eliminate insulin resistance, it is hypoglycemic to have the function that.Papaya hardship mulberry piece, which contains specificity organized enzyme chymopapain, can cut off glucose and protein and rely the covalent bond of combination, and glycosylated protein is made to resolve into glucose and protein.The diabetic complications such as angiocarpy, kidney, eyes, nerve, ulcer of foot are controlled and alleviate caused by capable of making protein glycosylation.

Description

Hypoglycemic papaya hardship mulberry tablet or capsule and its preparation process
Technical field
The present invention relates to a kind of hypoglycemic papaya hardship mulberry tablet or capsules and preparation method thereof.
Background technology
Papaya ingredient containing multiple biological activities mainly has chymopapain (chymopapain, abbreviation CHP), wood Melon chrymotrypsin M (glycylendopeptidase, abbreviation GEP), papain (papain, abbreviation PAP), pawpaw egg White enzyme Ω (papaya proteinase, abbreviation CAR), lysozyme (abbreviation LYS), II type chitinase (CHI), lipase etc.. Pawpaw organized enzyme has antiinflammation, can replace each inflammation lesion pancreas islet anti-inflammatory in pancreas, makes organized renewing healthy, normal point Insulin is secreted, while to each organ-tissue anti-inflammatory of human body, recovery organ tissue health.Due in chronic inflammation processes, having not Same T cell is activated, and antigen is spread in disease progression, and the fermentoid is under Pharmacological serum concentration, B cell inflammation phase Close a series of autoimmune response T- cell clone proliferations be suppressed, can eliminate T- cells and Antigen Presenting Cell surface by The expression of body can interfere immune response to achieve the purpose that adjust T- cell activity by polytropism.Cytokine analysis Show that these bioactive enzymes contained by this product can selectively inhibit the generation of inflammation promotive factor (TH-1).T- cells according to It is the major reason for causing B cell inflammatory destruction to rely property immune-mediated, therefore, the multidirectional immunoregulation effect of the fermentoid, B cell inflammation can be eliminated, the function of B cell excreting insulin is restored, is the basis for treating autoimmune diabetes. In addition, inflammation islet B-cells secrete more amylins than normal B-cells, the deposition of amylin can cause islet amyloid sample Denaturation, eventually leads to islet B-cells atrophy and quantity is reduced.With the elimination of islet B-cells, amylin secretion is reduced, just Amylin deposition will not be formed, the atrophy and reduction of islet B-cells are also avoided.Also contain lysozyme, fat in papaya The enzymes such as enzyme, oxidizing ferment, peptase, cellulase, energy of these enzymes with proteolysis and synthesis capability, hydrolyzed fat and grease Power has and adjusts gastrointestinal function, digestive ability, can enhance the constitution of diabetic, boost metabolism, eliminate Body fat improves body glucose metabolic capability, equally plays the role of various symptoms that are hypoglycemic and alleviating diabetes.
Balsam pear, mulberry leaf, campanulaceae, Chinese yam are common, the definitely reliable Chinese medicine of blood sugar decreasing effect, and association is played with papaya compatibility Same-action, hypoglycemic effect are more notable.
The pathogenic key mechanism of diabetes is both ends, and one is to generate the organ of insulin to go wrong, i.e. B cell point Secrete the function reduction of insulin；Other end is glucose to be converted into using insulin the body tissue of energy to go wrong, i.e. pancreas Insulin resistance.B cell secreting function decline and insulin resistance to the formation and development of diabetes play reciprocal causation, mutually The effect mutually promoted, here it is the two-way pathogenic mechanisms of diabetes.Insulin resistance is exactly surrounding tissue such as muscle, liver, fat To the insensitive of insulin.To insulin insensitivity, after all, be exactly muscle, liver, the insulin on adipocyte plasma membrane by Body is out of joint.It causes the insulin receptor on cell membrane there is a problem for some reason, function of receptors is made to decline or count Amount is reduced, and the ability that insulin normally cannot be combined or be combined with receptor is decreased obviously, and same amount of insulin cannot play There is hyperglycemia, such case is referred to as pancreas by we to prevent blood glucose from eubolism and conversion in due hypoglycemic effect Insulin resistance.The basic reason of insulin resistance is that insulin receptor function reduction and quantity are reduced on cell membrane.Due to pancreas islet Element is resisted, and the glucose in blood cannot enter intracellular participation metabolism and conversion activity, lead to hyperglycemia, hyperglycemia is in turn Stimulation B cell additionally secretes more insulin, can just blood glucose be made to lower, and the insulin in blood is higher than normal at this time Level forms hyperinsulinemia.Insulin resistance causes B cell to secrete more insulin, and B cell is made to bear It aggravates, the time is grown, and B cell strain, secreting function declines.When B cell can not normal secretions insulin, in addition week The insulin resistance of tissue is enclosed, the glucose in blood, which is more difficult to enter, participates in normal energetic supersession and conversion in histocyte, Existence and physiological activity due to receptor need energy, and the missing of energy causes the quantity of receptor to reduce again, function reduction.Thus As it can be seen that pancreas B cell function decline and insulin resistance, the two to the generation and development of diabetes play reciprocal causation, mutually The effect of promotion, here it is the two-way pathogenic mechanisms that diabetes are formed.
One, two-way hypoglycemic mechanism：(1), B cell is repaired, the function of B cell excreting insulin is restored.1, Eliminate pancreas islet chronic inflammation.T- cells are a quasi-lymphocyte, T- cells and the antigenic action in pancreas islet, to activate inflammation to promote Into the factor (TH-1), pancreas islet is made to generate anaphylaxis chronic inflammatory reaction, leads to that pancreas B cell function declines or even function is complete It loses.Drug containing bioactive enzyme GEP and CHI can inhibit T- cell clones to increase since these enzymes have pancreas islet targeting It grows and its active, pancreas islet anaphylaxis chronic inflammation is made to subside, pancreas B cell function restores.2, (amylin causes decomposition amylin B cell atrophy and rupture).Amylin is the amyloid polypeptide of B cell secretion, heavy in amyloid protein in pancreas islet It forms sediment.The precipitation of amylin causes islet amyloid sample to be denaturalized, and eventually leads to B cell atrophy and rupture.3, sugar poison is removed.High blood Sugar promotes glucose in blood to be combined generation sugar poison (glycosylation albumen) with pancreas islet capillary protein molecule, and the accumulation of sugar poison is simultaneously Crosslinking mutually makes capillary wall thickening, elasticity reduce, and capillary tube chamber narrows, causes pancreas islet blood supply insufficiency, eventually lead to B cell atrophy and quantity are reduced.(2) insulin resistance is eliminated, metabolism of blood glucose and conversion are promoted.Balsam pear contained by this product, Mulberry leaf, campanulaceae, Chinese yam and papaya synergistic effect can promote microcirculation, increase tissue keeping, vegetative cell, strengthen immunity Therefore effect has the function of insulin receptor on nutrition and repair cell film, restore sensibility of the receptor to insulin.It is bitter Melon, mulberry leaf, campanulaceae, Chinese yam and papaya synergistic effect eliminate pancreas islet chronic inflammation, decomposition leads to B cell atrophy and rupture Amylin, remove sugar poison, eliminate insulin resistance, these measures to effect a permanent cure are by nutrition, repair B cell and pancreas The methods of island element receptor, removing harmful substance make B cell and insulin receptor functional rehabilitation, number increase.Different from west Medicine, this product are to generate hypoglycemic by effecting a permanent cure, therefore hypoglycemic is persistently effective.
Two, glycosylation albumen is decomposed, complication mechanism is controlled.Glycosylation albumen is also sugared poison.Hyperglycemia makes glycans Change, protein loses physiological activity after being glycosylated.It is recently studies have found that non-between internal mistake hyperglycemia and protein Enzyme glycosylation, the irreversibility of final product are the basic reasons for leading to chronic complicating diseases of diabetes.Glycosylation can It is happened at the nearly all protein of body, but further glycosylation mostly occurs on the stage of replacement very long protein, these eggs It is the constitutive protein of eyes, blood vessel, internal organs, skin, nerve etc. in vain.Further glycosylated protein final product increase and heap Product causes institutional framework that the change of form and function occurs, to the occurrence and development of induced Diabetic chronic complicating diseases.
Hypoglycemic papaya hardship mulberry tablet or capsule, which contain specificity organized enzyme chymopapain, can cut off glucose and egg White matter is rely the covalent bond of combination, so that glycosylated protein is resolved into glucose and protein, is restored original normal condition.Base In the above mechanism, under the action of this product specificity bioactive enzyme, make to cause crystalline protein, collagen, elastin laminin and The glycosylation protein breakdown of myelin protein denaturation makes protein restore normal biological function at glucose and protein.Therefore, The diabetic complications such as angiocarpy, kidney, eyes, nerve, ulcer of foot caused by papaya hardship mulberry piece can make protein glycosylation It is controlled and alleviates.Hypoglycemic papaya hardship mulberry tablet or capsule are with the glycosuria for effectively decomposing glycosylated protein function Sick preparation.
Invention content
The present invention provides a kind of hypoglycemic papaya hardship mulberry tablet or capsule and its preparation processes.The present invention is using as follows Technical solution：
A kind of hypoglycemic papaya hardship mulberry tablet or capsule, including papaya hardship mulberry composition and dextrin are prepared.
The papaya hardship mulberry composition includes that following raw materials are prepared：
Papaya, balsam pear, mulberry leaf, campanulaceae, Chinese yam.
Preferably, the papaya hardship mulberry composition includes that the raw material of following weight parts is prepared：
5-10 parts of papaya, 1-5 parts of balsam pear, 2-6 parts of mulberry leaf, 3-7 parts of campanulaceae, 3-7 parts of Chinese yam.
The preparation process of hypoglycemic papaya hardship mulberry tablet or capsule according to any of the above item, including following steps Suddenly：
(1) pretreatment of raw material：(1) fresh papaya is taken, is cleaned, is dried or dry, then obtained through crushing or grinding Slurry, slurry take supernatant through centrifuging or squeeze, and ultrafiltration removes macromolecular polysaccharide, ultrafiltration permeate through low-temperature vacuum drying or Freeze-drying obtains solid, and solid is ground into fine powder, spare；(2) balsam pear, mulberry leaf, campanulaceae, Chinese yam are taken, is cleaned, is dried or dry Dry, mixing is ground into fine powder, sterilizes, spare；Described dry of step (1) is dried at 25-30 DEG C to removing papaya surface water Point, step (1) drying is to be dried to remove papaya surface moisture at 25-40 DEG C, and described dry of step (2) is in 25- It is 6wt%-10wt% that 30 DEG C, which are dried to water content, and step (2) drying is that water content is dried at 25-40 DEG C as 6wt%- 10wt%；The granularity of the slurry is 0.2-0.3mm；The molecular cut off of the ultrafiltration membrane is 20000-50000Da；
(2) papaya hardship mulberry composition is prepared：It takes the fine powder of (1) and (2) to be uniformly mixed and obtains papaya hardship Sang Zuhe Object；
(3) tablet or capsule is made.
Tablet is made described in step (3), includes the following steps：
Into papaya hardship mulberry composition plus dextrin is uniformly mixed, and adds suitable quantity of water that softwood is made, softwood is passed through 20-30 mesh Sieve forms particle, by particle at 40-50 DEG C it is dry after through tablet press machine be pressed into piece, packaging to get.It is further that tablet step is made Preferably into papaya hardship mulberry composition plus dextrin is uniformly mixed, then it is 7wt%-8wt%'s to add suitable quantity of water that water content is made Softwood is formed particle by softwood by 20-30 mesh screens, and it is 3wt%-4wt% that particle, which is dried at 40-50 DEG C to water content, Be pressed into piece through tablet press machine, packaging to get.
Capsule is made described in step (3), includes the following steps：
Into papaya hardship mulberry composition plus dextrin is uniformly mixed, and is directly loadable into capsule using capsule filling machine, is packed, i.e., .
In some embodiments of the invention, the papaya hardship mulberry composition include following weight parts raw material prepare and At：
5-10 parts of papaya, 1-5 parts of balsam pear, 2-6 parts of mulberry leaf, 3-7 parts of campanulaceae, 3-7 parts of Chinese yam, rose hip witloof powder 1-3 Part.The preparation process of the papaya hardship mulberry piece or capsule includes the following steps：(1) pretreatment of raw material：(1) it takes fresh Papaya is cleaned, dries or dry, and obtains slurry through crushing or grinding, slurry takes supernatant, big point of ultrafiltration removal through centrifugation Sub- polysaccharide, ultrafiltration permeate obtains solid through low-temperature vacuum drying or freeze-drying, solid is ground into fine powder, spare；(2) it takes Balsam pear, mulberry leaf, campanulaceae, Chinese yam are cleaned, dry or dry, and mix, are ground into fine powder, sterilize, spare.Step (1) is described to dry It is to be dried at 25-30 DEG C to papaya surface moisture is removed, step (1) drying is to be dried to remove kind wood at 25-40 DEG C Melon surface moisture, it is that be dried at 25-30 DEG C to water content be 6wt%-10wt%, step (2) described baking that step (2) is described, which to dry, Dry is that water content is dried at 25-40 DEG C as 6wt%-10wt%.The granularity of the slurry is 0.2-0.3mm.The ultrafiltration membrane Molecular cut off be 20000-50000Da.(2) papaya hardship mulberry composition is prepared：Take fine powder, the rose hip of (1) and (2) Witloof powder is uniformly mixed and obtains papaya hardship mulberry composition.(3) tablet or capsule is made.The tablet that is made is：To papaya Dextrin is added in bitter mulberry composition to be uniformly mixed, then adds suitable quantity of water that the softwood that water content is 7wt%-8wt% is made, softwood is led to It crosses 20-30 mesh screens and forms particle, it is 3wt%-4wt% that particle, which is dried at 40-50 DEG C to water content, is pressed into through tablet press machine Piece, packaging to get.The capsule that is made is：Into papaya hardship mulberry composition plus dextrin is uniformly mixed, and uses capsule filling machine Be directly loadable into capsule, packaging to get.
In other embodiments of the present invention, the papaya hardship mulberry composition includes prepared by the raw material of following weight parts It forms：
5-10 parts of papaya, 1-5 parts of balsam pear, 2-6 parts of mulberry leaf, 3-7 parts of campanulaceae, 3-7 parts of Chinese yam, rose hip witloof powder 1-3 Part, 0.2-0.8 parts of auxiliary agent.The auxiliary agent is peony extract, modified peony extract, hickory kernel extract, modified mountain core One or more mixture in Semen Persicae extract.The preferably modified peony extract of the auxiliary agent and modified hickory kernel extract The mixture of object, the modified peony extract and modified hickory kernel extract quality ratio are (1-3)：(1-3).Kind The preparation process of pawpaw hardship mulberry piece includes the following steps：(1) pretreatment of raw material：(1) take fresh papaya, clean, dry or Drying obtains slurry through crushing or grinding, and slurry takes supernatant, ultrafiltration to remove macromolecular polysaccharide, ultrafiltration permeate warp through centrifugation Low-temperature vacuum drying or freeze-drying obtain solid, and solid is ground into fine powder, spare；(2) balsam pear, mulberry leaf, campanulaceae, mountain are taken Medicine is cleaned, dries or dry, and mixes, is ground into fine powder, sterilizes, spare；Step (1) is described dry be dried at 25-30 DEG C to Papaya surface moisture is removed, step (1) drying is to be dried to remove papaya surface moisture, step (2) at 25-40 DEG C It is described dry be dried at 25-30 DEG C to water content be 6wt%-10wt%, step (2) it is described drying be at 25-40 DEG C dry It is 6wt%-10wt% to water content.The granularity of the slurry is 0.2-0.3mm.The molecular cut off of the ultrafiltration membrane is 20000-50000Da.(2) papaya hardship mulberry composition is prepared：The fine powder, rose hip witloof powder, auxiliary agent of (1) and (2) is taken to mix Uniformly obtain papaya hardship mulberry composition.(3) tablet or capsule is made：The tablet that is made is：To papaya hardship mulberry composition Middle addition dextrin is uniformly mixed, then adds suitable quantity of water that the softwood that water content is 7wt%-8wt% is made, and softwood is passed through 20-30 mesh Sieve forms particle, and it is 3wt%-4wt% that particle, which is dried at 40-50 DEG C to water content, and piece is pressed into through tablet press machine, is packed, i.e., .The capsule that is made is：Into papaya hardship mulberry composition plus dextrin is uniformly mixed, and glue is directly loadable into using capsule filling machine Capsule, packaging to get.
Hypoglycemic papaya hardship mulberry tablet according to any of the above item or capsule, the dextrin are cyclodextrin or malt Dextrin, preferably maltodextrin.
Hypoglycemic papaya hardship mulberry tablet according to any of the above item or capsule, the papaya hardship mulberry composition and The mass ratio of dextrin is 1：(0.6-2.3), the preferably mass ratio of papaya hardship mulberry composition and maltodextrin are 1：(0.6- 2.3)。
The preparation process of hypoglycemic papaya hardship mulberry tablet or capsule according to any of the above item, it is described centrifugation be with 5000-15000 revs/min of rotating speed centrifuges 10-40min.
The preparation process of hypoglycemic papaya hardship mulberry tablet or capsule according to any of the above item, which is characterized in that The sterilizing is that the ultraviolet irradiation 0.5-1h for being 254nm with wavelength carries out sterilization treatment.
The hypoglycemic papaya hardship mulberry tablet or capsule of the present invention, the balsam pear contained, mulberry leaf, campanulaceae, Chinese yam and papaya Synergistic effect can promote microcirculation, increase the effect of tissue keeping, vegetative cell, strengthen immunity, therefore, have nutrition and repair The effect of insulin receptor on multiple cell membrane, restores sensibility of the receptor to insulin.Balsam pear, mulberry leaf, campanulaceae, Chinese yam and kind wood Melon synergistic effect can eliminate pancreas islet chronic inflammation, decomposition leads to the amylin of B cell atrophy and rupture, it is malicious to remove sugar, Eliminate insulin resistance.It is hypoglycemic to have the function that.Papaya hardship mulberry piece or capsule contain specificity organized enzyme Chymopapain can cut off glucose and protein and rely the covalent bond of combination, make glycosylated protein resolve into glucose and Protein restores original normal condition.Hypoglycemic papaya hardship mulberry tablet or capsule can make the heart caused by protein glycosylation The diabetic complications such as blood vessel, kidney, eyes, nerve, ulcer of foot are controlled and alleviate.Hypoglycemic papaya hardship mulberry tablet or Capsule has the function of effectively to decompose glycosylated protein.
On the basis of common knowledge of the art, above-mentioned each optimum condition, can be each preferably to get the present invention in any combination Embodiment.
Specific implementation mode
It is further illustrated the present invention below by the mode of embodiment, but does not therefore limit the present invention to the reality It applies among a range.In the following examples, the experimental methods for specific conditions are not specified, according to conventional methods and conditions, or according to quotient Product specification selects.
Part material is described below in embodiment：
Papaya, Classification system：Carica Papaya L. use the fresh fruit that position is papaya.In papaya Also contain the enzymes such as lysozyme, lipase, oxidizing ferment, peptase, cellulase, these enzymes have proteolysis and synthesis capability, water Solution fat and grease ability, have adjust gastrointestinal function, digestive ability, can enhance diabetic constitution, It boosts metabolism, eliminates body fat, improves body glucose metabolic capability, equally play hypoglycemic and alleviation diabetes The effect of various symptoms.Carpaine in papaya has the strong active anticancer of Hangzhoupro lymhocytic leukaemia cells (L1210) With the appropriateness activity of anti-lymphoid leukemia P388 and EA tumour cell.
Balsam pear, Classification system：Momordica charantia L. are fresh fruit using position.Contain hardship in balsam pear Melon saponin(e has the apparent blood glucose that reduces to act on.After rabbit that is normal and suffering from alloxan diabetes gavages balsam pear juice, Blood glucose can be made to be substantially reduced.The rat that anteriorpituitary medicinal extract causes hyperglycemia is subcutaneously injected, gavages the water extraction of balsam pear juice Object also plays the role of reducing blood glucose.
Mulberry leaf, Classification system：Morus alba L. are the dried leafs of moraceae plants mulberry.Sugar compounds containing N- in mulberry leaf, Have the function of that blood glucose is inhibited to rise.In modern times, doctor trained in Western medicine is using mulberry leaf and mulberry leaf biological agent as improving diabetes and other are each It plants the drug of difficult and complicated cases and uses, it is believed that its drug effect is extremely wide.There is clearing away the lungheat and moisturizing, cough-relieving, reduces phlegm and internal heat, resolving sputum, controls night sweat；It mends Liver clears liver and improve vision, treats dizzy, insomnia, eliminates eye strain；Subside a swelling, purify the blood, treats dysentery, abdominal pain, weight-reducing, removes foot Gas, the large and small intestines of profit；Resisting stress, lowering blood pressure and blood fat, prevents myocardial infarction, cerebral hemorrhage, headache of dispelling at cool blood；Hypoglycemic, anti-sugar Disease etc..
Campanulaceae is the dry root of Campanulaceae campanulaceae Platycodon grandiflorum (Jacq.) A.DC..Campanulaceae With hypoglycemic effect：Rabbit gavage campanulaceae water or alcohol extracting thing 200mg/kg can be such that blood glucose declines, the hypoglycemic song of water extract Line is similar to gavage 25~50mg/kg tolbutamides.Water and the continuous 4 days gavages of alcohol extracting thing 500mg/kg, to experimental four oxygen Pyrimidine Diabetic Rabbits also have hypoglycemic effect.
Chinese yam is the dry rhizome of Dioscoreaceae plant Chinese yam Dioscorea opposita Thunb..Contained in Chinese yam Polysaccharide protein is hydrolyzed to protein and carbohydrate in vivo, plays the role of reducing blood glucose.Chinese yam has antitumor action, and Chinese yam can Stimulation and adjusting human immune system.Therefore the health medicine for often making enhancing immunocompetence uses.Chinese yam can also reinforce leucocyte Phagocytosis.Such as, Liuwei Dihuang Wan can treat the illnesss such as chronic nephritis, hypertension, diabetes, neurasthenia.
Rose hip is the fresh fruit of rosaceous plant Rosa bella Rosa davurica Pall..Rose hip, which has, to be delayed Aging, repairs radiation injury, is hypoglycemic, reducing blood pressure and cerebral vascular resistance enhancing cellular immunity, inhibition thrombosis, shield The effect of liver packet liver.Witloof, the ground for being feverfew saussurea intybus Cichorium glandulosum Boiss.et Hout are dry Dry part.Witloof effect mainly has liver-protecting and blood fat-reducing, hypoglycemic, promotion gastric secretion, improves appetite, improves digestive function.Witloof Blood glucose can be reduced, while reducing the blood fat of diabetic, reduces the generation of macrovascular complications.A variety of hepatotoxic agents are caused Hepar damnification have significant protective effect.There is preferable treat to acute, chronic hepatitis, cirrhosis and metabolism toxic liver injury Effect, there is prodigious medical value.The preparation method of rose hip witloof powder is as follows in embodiment：Witloof is crushed, 10 mesh sieve is crossed, obtains It is beaten 15 minutes with 12000 revs/min of rotating speeds after mixing 250g rose hips, 300g water to witloof powder, obtains rose hip slurry, Rose hip slurry is warming up to 85 DEG C, keep the temperature 40 minutes at 85 DEG C, is cooled to 35 DEG C, addition 170g witloofs powder, 1.5g citric acids, 35g lactobacillus plantarum (Classification systems：Lactobacillus plantarum are carried by the Xi'an bio tech ltd Yun He For bacterial strain content 10,000,000,000 cfu/g, model YH-626), 25g beta-glucosidases (No. CAS：9001-22-3, enzyme activity：30u/ Mg, the Shanghai bio tech ltd Yuan Ju provide, product identification：E0762 it) seals after mixing, it is small that 48 is kept the temperature at 35 DEG C When, 50 mesh sieve is then crossed, filter cake is 24 hours dry at 50 DEG C, and the ultraviolet irradiation 1h for being 254nm with wavelength is sterilized, then 80 mesh sieve is crushed, rose hip witloof powder is obtained.Both rose hip, witloof act synergistically, and have good hypoglycemic, drop blood Fat, strengthen immunity effect.Toxic side effect can be reduced by enzymolysis and fermentation treatments, while increasing drug effect.
RADIX PAEONIAE RUBRA, is the dry root of ranunculaceae plant river radix paeoniae rubra, and root contains Paeoniflorin.Paeoniflorin and its derivative are to dropping blood Sugar, reducing blood lipid, it is antitumor have good pharmacological action.The preparation method of peony extract described in embodiment is as follows：It will be red Chinese herbaceous peony crushed 60 mesh and sieve to obtain powder, by 120g RADIX PAEONIAE RUBRAs powder with 1500g pH be 4.5 glacial acetic acid aqueous solution at 28 DEG C Impregnate 3 hours, sieve with 100 mesh sieve, filter cake is subjected to ultrasonic extraction, ultrasonic extraction 1 hour crosses 200 mesh sieve, obtain first-time filtrate and Filter cake and the pH glacial acetic acid aqueous solutions for being 4.5 are 1 in mass ratio by filter cake:6 mixing, ultrasonic extraction 30 minutes, mistake 200 mesh sieve, and obtain secondary filtrate and secondary filter cake, merge first-time filtrate and secondary filtrate, obtain mixing filtrate, will mix filtrate It is mixed with isometric ethyl acetate, extracts, be then allowed to stand 1 hour, remove a layer extract liquor, by extract liquor in 40 DEG C, absolute pressure It is concentrated under reduced pressure into the 1/10 of original volume for 0.01MPa, 60 turns/min items, concentrate is true for 35kPa conditions in 40 DEG C, vacuum degree Sky is 24 hours dry, obtains peony extract.The ultrasonic frequency of the ultrasonic extraction is 40KHz, power 500W.
The preparation method of modified peony extract is as follows in embodiment：The 5g peony extracts prepared as stated above is molten Solution is in 100mL water, and under 25 DEG C, 200 turns/min stirring conditions, a concentration of 0.2mol/L of 50mL are added with 1mL/min speed NaIO4Aqueous solution continues under 25 DEG C, 200 turns/min stirring conditions, and it is a concentration of that 50mL is added with 1.5mL/min speed The NaBH of 0.2mol/L4Aqueous solution continues under 25 DEG C, 200 turns/min stirring conditions, and 12mL is added with 1.5mL/min speed The HCl/water solution that mass fraction is 1%, obtains mixed liquor, and mixed liquor is concentrated into 3 DEG C, absolute pressure for 0.01MPa conditions The 1/50 of original volume, the ethyl alcohol that 50g mass fractions are 95% is added into concentrate, is uniformly mixed, and then crosses 50 mesh sieve, will filter Ethyl alcohol is recovered under reduced pressure in liquid, obtains modified peony extract.
Hickory kernel is the benevolence of juglandaceae plant hickory nut.Classification system：Carya cathayensis Sarg..Mountain Contain hypoglycemic, blood fat reducing function sitosterol and other a variety of sterols in walnut kernel.Hickory kernel extract passes through modified energy Obtain suitable or better hypoglycemic, lipid-lowering effect.The preparation method of hickory kernel extract is as follows in embodiment：By hickory nut Benevolence crushing sieves with 100 mesh sieve, and it is 5wt% to be dried at 40 DEG C to water content, and hickory kernel powder 5kg is taken to carry out CO 2 supercritical extraction It takes, I pressure of separating still is 8MPa, and temperature is 40 DEG C, and II pressure of separating still is 5MPa, and temperature is 30 DEG C, and carbon dioxide flow rate is 20L/h, extraction time are 4 hours, the extract collected, as hickory kernel extract.
The preparation method of modified hickory kernel extract is as follows in embodiment：It is added into flask and to prepare as stated above 50mL acetonitriles are added in 3g hickory kernel extracts, under 25 DEG C, 250 revs/min of stirring conditions, are added with the speed of 1mL/min The methanol solution of the dimethylamine of 8mL, a concentration of 1mmol/mL is warming up to 48 DEG C, is reacted 6 hours at 48 DEG C, is then cooled to 37 DEG C, it is concentrated to dryness in 37 DEG C, absolute pressure 0.01MPa, 50 revs/min of conditions, by the 50g ether of residue in flask It is dried in vacuo 6 hours for 35kPa conditions in 35 DEG C, vacuum degree after washing, obtains modified hickory kernel extract.
It is further illustrated the present invention below by the mode of embodiment.
Embodiment 1
A kind of hypoglycemic papaya hardship mulberry tablet, including papaya hardship mulberry composition and dextrin are prepared.Described kind of wood Melon hardship mulberry composition includes that the raw material of following weight parts is prepared：
8 parts of papaya, 3.5 parts of balsam pear, 4 parts of mulberry leaf, 5 parts of campanulaceae, 5 parts of Chinese yam.
The preparation process of the papaya hardship mulberry piece, includes the following steps：
Pretreatment of raw material：(1) fresh papaya is taken, is cleaned, is dried at 28 DEG C to papaya surface moisture is removed, through grinding Mill obtains slurry, and slurry takes supernatant through centrifugation, and (molecular cut off of ultrafiltration membrane is ultrafiltration removal macromolecular polysaccharide 40000Da), through low-temperature vacuum drying, (low-temperature vacuum drying is temperature is 5 DEG C, vacuum degree is to ultrafiltration permeate 35kPa, drying time are 36 hours) solid is obtained, solid is ground into 80 mesh fine powders, it is spare；(2) balsam pear, mulberry leaf, tangerine are taken Stalk, Chinese yam are cleaned, and it is 8wt% to be dried at 28 DEG C respectively to water content, and mixing is ground into 80 mesh fine powders, sterilizes, spare；
Prepare papaya hardship mulberry composition：It takes the fine powder of (1) and (2) to be uniformly mixed and obtains papaya hardship mulberry composition；
Tablet is made：Into papaya hardship mulberry composition plus appropriate maltodextrin is uniformly mixed, then is added suitable quantity of water to be made and contained Water is the softwood of 7wt%, and softwood is formed particle by 20 mesh screens, and it is 3wt% that particle, which is dried at 50 DEG C to water content, Be pressed into piece through tablet press machine, packaging to get.It is 0.5g per sheet weight.
Embodiment 2
A kind of hypoglycemic papaya hardship mulberry capsule, including papaya hardship mulberry composition and dextrin are prepared.Described kind of wood Melon hardship mulberry composition includes that the raw material of following weight parts is prepared：
8 parts of papaya, 3.5 parts of balsam pear, 4 parts of mulberry leaf, 5 parts of campanulaceae, 5 parts of Chinese yam.
The preparation process of the papaya hardship mulberry capsule, includes the following steps：
Pretreatment of raw material：1) fresh papaya is taken, is cleaned, is dried at 28 DEG C to papaya surface moisture is removed, through grinding Mill obtains slurry, and slurry takes supernatant through centrifugation, and (molecular cut off of ultrafiltration membrane is ultrafiltration removal macromolecular polysaccharide 40000Da), through low-temperature vacuum drying, (low-temperature vacuum drying is temperature is 5 DEG C, vacuum degree is to ultrafiltration permeate 35kPa, drying time are 36 hours) solid is obtained, solid is ground into 80 mesh fine powders, it is spare；(2) balsam pear, mulberry leaf, tangerine are taken Stalk, Chinese yam are cleaned, and it is 8wt% to be dried at 28 DEG C respectively to water content, and mixing is ground into 80 mesh fine powders, sterilizes, spare；
Prepare papaya hardship mulberry composition：It takes the fine powder of (1) and (2) to be uniformly mixed and obtains papaya hardship mulberry composition；
Capsule is made：Into papaya hardship mulberry composition plus maltodextrin is uniformly mixed, and is directly filled using capsule filling machine Enter capsule, each capsule fills 0.5g, packaging to get.The mass ratio of the papaya hardship mulberry composition and maltodextrin is 1: 1。
Embodiment 3
A kind of hypoglycemic papaya hardship mulberry tablet, including papaya hardship mulberry composition and dextrin are prepared.Described kind of wood Melon hardship mulberry composition includes that the raw material of following weight parts is prepared：
8 parts of papaya, 3.5 parts of balsam pear, 4 parts of mulberry leaf, 5 parts of campanulaceae, 5 parts of Chinese yam.
The preparation process of the papaya hardship mulberry piece, includes the following steps：
Pretreatment of raw material：(1) fresh papaya is taken, is cleaned, is dried at 28 DEG C to papaya surface moisture is removed, through grinding Mill obtains the slurry that granularity is 0.2mm, and slurry centrifuges 15min through 8000 revs/min of rotating speeds, takes supernatant, big point of ultrafiltration removal The molecular cut off of sub- polysaccharide, ultrafiltration membrane is 40000Da, and ultrafiltration permeate is through the low-temperature vacuum drying (low-temperature vacuum drying For be 5 DEG C in temperature, vacuum degree 35kPa, drying time be 36 hours) obtain solid, solid is ground into 80 mesh fine powders, it is standby With；(2) balsam pear, mulberry leaf, campanulaceae, Chinese yam are taken, is cleaned, it is 8wt% to be dried at 28 DEG C respectively to water content, and mixing is ground into 80 The ultraviolet irradiation 1h that mesh fine powder is 254nm with wavelength sterilizes, spare；
Prepare papaya hardship mulberry composition：It takes the fine powder of (1) and (2) to be uniformly mixed and obtains papaya hardship mulberry composition；
Tablet is made：Into papaya hardship mulberry composition be added maltodextrin be uniformly mixed, then add suitable quantity of water be made it is aqueous Amount is the softwood of 7wt%, and softwood is formed particle by 20 mesh screens, and it is 3wt%, warp that particle, which is dried at 50 DEG C to water content, Tablet press machine is pressed into piece, packaging to get.The mass ratio of the papaya hardship mulberry composition and maltodextrin is 1:1.It is per sheet weight 0.5g。
Comparative example 1
A kind of tablet, including composition and dextrin are prepared.The composition includes prepared by the raw material of following weight parts It forms：
3.5 parts of balsam pear, 4 parts of mulberry leaf, 5 parts of campanulaceae, 5 parts of Chinese yam.
The preparation process of the tablet, includes the following steps：
Pretreatment of raw material：Balsam pear, mulberry leaf, campanulaceae, Chinese yam are taken, is cleaned, it is 8wt% to be dried at 28 DEG C respectively to water content, Mixing, is ground into 80 mesh fine powders, the ultraviolet irradiation 1h for being 254nm with wavelength sterilizes, and obtains composition；
Tablet is made：Maltodextrin is added into composition to be uniformly mixed, then it is 7wt%'s to add suitable quantity of water that water content is made Softwood is formed particle by softwood by 20 mesh screens, and it is 3wt% that particle, which is dried at 50 DEG C to water content, is pressed into through tablet press machine Piece, packaging to get.The mass ratio of the composition and maltodextrin is 1:1.It is 0.5g per sheet weight.
Comparative example 2
A kind of tablet, including composition and dextrin are prepared.The composition includes prepared by the raw material of following weight parts It forms：
8 parts of papaya, 3.5 parts of balsam pear, 5 parts of campanulaceae, 5 parts of Chinese yam.
The preparation process of the tablet, includes the following steps：
Pretreatment of raw material：(1) fresh papaya is taken, is cleaned, is dried at 28 DEG C to papaya surface moisture is removed, through grinding Mill obtains the slurry that granularity is 0.2mm, and slurry centrifuges 15min through 8000 revs/min of rotating speeds, takes supernatant, big point of ultrafiltration removal The molecular cut off of sub- polysaccharide, ultrafiltration membrane is 40000Da, and ultrafiltration permeate is through the low-temperature vacuum drying (low-temperature vacuum drying For be 5 DEG C in temperature, vacuum degree 35kPa, drying time be 36 hours) obtain solid, solid is ground into 80 mesh fine powders, it is standby With；(2) balsam pear, campanulaceae, Chinese yam are taken, is cleaned, it is 8wt% to be dried at 28 DEG C respectively to water content, and it is thin to be ground into 80 mesh for mixing The ultraviolet irradiation 1h that powder is 254nm with wavelength sterilizes, spare；
Prepare composition：It takes the fine powder of (1) and (2) to be uniformly mixed and obtains composition；
Tablet is made：Maltodextrin is added into composition to be uniformly mixed, then it is 7wt%'s to add suitable quantity of water that water content is made Softwood is formed particle by softwood by 20 mesh screens, and it is 3wt% that particle, which is dried at 50 DEG C to water content, is pressed into through tablet press machine Piece, packaging to get.The mass ratio of the composition and maltodextrin is 1:1.It is 0.5g per sheet weight.
Comparative example 3
A kind of tablet, including composition and dextrin are prepared.The composition includes prepared by the raw material of following weight parts It forms：
8 parts of papaya, 3.5 parts of balsam pear, 4 parts of mulberry leaf, 5 parts of campanulaceae, 5 parts of Chinese yam, 5 parts of cassia seed.
The preparation process of the tablet, includes the following steps：
Pretreatment of raw material：(1) fresh papaya is taken, is cleaned, is dried at 28 DEG C to papaya surface moisture is removed, through grinding Mill obtains the slurry that granularity is 0.2mm, and slurry centrifuges 15min through 8000 revs/min of rotating speeds, takes supernatant, big point of ultrafiltration removal The molecular cut off of sub- polysaccharide, ultrafiltration membrane is 40000Da, and ultrafiltration permeate is through the low-temperature vacuum drying (low-temperature vacuum drying For be 5 DEG C in temperature, vacuum degree 35kPa, drying time be 36 hours) obtain solid, solid is ground into 80 mesh fine powders, it is standby With；(2) balsam pear, mulberry leaf, campanulaceae, Chinese yam, cassia seed are taken, is cleaned, it is 8wt%, mixing, powder to be dried at 28 DEG C respectively to water content 80 mesh fine powders are broken into, the ultraviolet irradiation 1h for being 254nm with wavelength sterilizes, spare；
Prepare composition：It takes the fine powder of (1) and (2) to be uniformly mixed and obtains composition；
Tablet is made：Maltodextrin is added into composition to be uniformly mixed, then it is 7wt%'s to add suitable quantity of water that water content is made Softwood is formed particle by softwood by 20 mesh screens, and it is 3wt% that particle, which is dried at 50 DEG C to water content, is pressed into through tablet press machine Piece, packaging to get.The mass ratio of the composition and maltodextrin is 1:1.It is 0.5g per sheet weight.
Embodiment 4
A kind of hypoglycemic papaya hardship mulberry tablet, including papaya hardship mulberry composition and dextrin are prepared.Described kind of wood Melon hardship mulberry composition includes that the raw material of following weight parts is prepared：
8 parts of papaya, 3.5 parts of balsam pear, 4 parts of mulberry leaf, 5 parts of campanulaceae, 5 parts of Chinese yam, 2.5 parts of rose hip witloof powder.
The preparation process of the papaya hardship mulberry piece, includes the following steps：
Pretreatment of raw material：(1) fresh papaya is taken, is cleaned, is dried at 28 DEG C to papaya surface moisture is removed, through grinding Mill obtains the slurry that granularity is 0.2mm, and slurry centrifuges 15min through 8000 revs/min of rotating speeds, takes supernatant, big point of ultrafiltration removal The molecular cut off of sub- polysaccharide, ultrafiltration membrane is 40000Da, and ultrafiltration permeate is through the low-temperature vacuum drying (low-temperature vacuum drying For be 5 DEG C in temperature, vacuum degree 35kPa, drying time be 36 hours) obtain solid, solid is ground into 80 mesh fine powders, it is standby With；(2) balsam pear, mulberry leaf, campanulaceae, Chinese yam are taken, is cleaned, it is 8wt% to be dried at 28 DEG C respectively to water content, and mixing is ground into 80 The ultraviolet irradiation 1h that mesh fine powder is 254nm with wavelength sterilizes, spare；
Prepare papaya hardship mulberry composition：It takes the fine powder of (1) and (2), rose hip witloof powder to be uniformly mixed and obtains papaya Bitter mulberry composition；
Tablet is made：Into papaya hardship mulberry composition be added maltodextrin be uniformly mixed, then add suitable quantity of water be made it is aqueous Amount is the softwood of 7wt%, and softwood is formed particle by 20 mesh screens, and it is 3wt%, warp that particle, which is dried at 50 DEG C to water content, Tablet press machine is pressed into piece, packaging to get.The mass ratio of the papaya hardship mulberry composition and maltodextrin is 1:1.It is per sheet weight 0.5g。
Embodiment 5
A kind of hypoglycemic papaya hardship mulberry tablet, including papaya hardship mulberry composition and dextrin are prepared.Described kind of wood Melon hardship mulberry composition includes that the raw material of following weight parts is prepared：
8 parts of papaya, 3.5 parts of balsam pear, 4 parts of mulberry leaf, 5 parts of campanulaceae, 5 parts of Chinese yam, 2.5 parts of rose hip witloof powder, auxiliary agent 0.5 Part.
The auxiliary agent is the mixture of modified peony extract and modified hickory kernel extract, the modified Chinese herbaceous peony extraction The mass ratio of object and modified hickory kernel extract is 1:1.
The preparation process of the papaya hardship mulberry piece, includes the following steps：
Pretreatment of raw material：(1) fresh papaya is taken, is cleaned, is dried at 28 DEG C to papaya surface moisture is removed, through grinding Mill obtains the slurry that granularity is 0.2mm, and slurry centrifuges 15min through 8000 revs/min of rotating speeds, takes supernatant, big point of ultrafiltration removal The molecular cut off of sub- polysaccharide, ultrafiltration membrane is 40000Da, and ultrafiltration permeate is through the low-temperature vacuum drying (low-temperature vacuum drying For be 5 DEG C in temperature, vacuum degree 35kPa, drying time be 36 hours) obtain solid, solid is ground into 80 mesh fine powders, it is standby With；(2) balsam pear, mulberry leaf, campanulaceae, Chinese yam are taken, is cleaned, it is 8wt% to be dried at 28 DEG C respectively to water content, and mixing is ground into 80 The ultraviolet irradiation 1h that mesh fine powder is 254nm with wavelength sterilizes, spare；
Prepare papaya hardship mulberry composition：It takes the fine powder, rose hip witloof powder, auxiliary agent of (1) and (2) to be uniformly mixed to obtain kind Pawpaw hardship mulberry composition；
Tablet is made：Into papaya hardship mulberry composition be added maltodextrin be uniformly mixed, then add suitable quantity of water be made it is aqueous Amount is the softwood of 7wt%, and softwood is formed particle by 20 mesh screens, and it is 3wt%, warp that particle, which is dried at 50 DEG C to water content, Tablet press machine is pressed into piece, packaging to get.The mass ratio of the papaya hardship mulberry composition and maltodextrin is 1:1.It is per sheet weight 0.5g。
Embodiment 6
A kind of hypoglycemic papaya hardship mulberry tablet, including papaya hardship mulberry composition and dextrin are prepared.Described kind of wood Melon hardship mulberry composition includes that the raw material of following weight parts is prepared：
8 parts of papaya, 3.5 parts of balsam pear, 4 parts of mulberry leaf, 5 parts of campanulaceae, 5 parts of Chinese yam, 2.5 parts of rose hip witloof powder, auxiliary agent 0.5 Part.
The auxiliary agent is the mixture of peony extract and hickory kernel extract, the peony extract and hickory kernel The mass ratio of extract is 1:1.
The preparation process of the papaya hardship mulberry piece, includes the following steps：
Pretreatment of raw material：(1) fresh papaya is taken, is cleaned, is dried at 28 DEG C to papaya surface moisture is removed, through grinding Mill obtains the slurry that granularity is 0.2mm, and slurry centrifuges 15min through 8000 revs/min of rotating speeds, takes supernatant, big point of ultrafiltration removal The molecular cut off of sub- polysaccharide, ultrafiltration membrane is 40000Da, and ultrafiltration permeate is through the low-temperature vacuum drying (low-temperature vacuum drying For be 5 DEG C in temperature, vacuum degree 35kPa, drying time be 36 hours) obtain solid, solid is ground into 80 mesh fine powders, it is standby With；(2) balsam pear, mulberry leaf, campanulaceae, Chinese yam are taken, is cleaned, it is 8wt% to be dried at 28 DEG C respectively to water content, and mixing is ground into 80 The ultraviolet irradiation 1h that mesh fine powder is 254nm with wavelength sterilizes, spare；
Prepare papaya hardship mulberry composition：It takes the fine powder, rose hip witloof powder, auxiliary agent of (1) and (2) to be uniformly mixed to obtain kind Pawpaw hardship mulberry composition；
Tablet is made：Into papaya hardship mulberry composition be added maltodextrin be uniformly mixed, then add suitable quantity of water be made it is aqueous Amount is the softwood of 7wt%, and softwood is formed particle by 20 mesh screens, and it is 3wt%, warp that particle, which is dried at 50 DEG C to water content, Tablet press machine is pressed into piece, packaging to get.The mass ratio of the papaya hardship mulberry composition and maltodextrin is 1:1.It is per sheet weight 0.5g。
Embodiment 7
A kind of hypoglycemic papaya hardship mulberry tablet, including papaya hardship mulberry composition and dextrin are prepared.Described kind of wood Melon hardship mulberry composition includes that the raw material of following weight parts is prepared：
8 parts of papaya, 3.5 parts of balsam pear, 4 parts of mulberry leaf, 5 parts of campanulaceae, 5 parts of Chinese yam, 2.5 parts of rose hip witloof powder, auxiliary agent 0.5 Part.
The auxiliary agent is modified peony extract.
The preparation process of the papaya hardship mulberry piece, includes the following steps：
Pretreatment of raw material：(1) fresh papaya is taken, is cleaned, is dried at 28 DEG C to papaya surface moisture is removed, through grinding Mill obtains the slurry that granularity is 0.2mm, and slurry centrifuges 15min through 8000 revs/min of rotating speeds, takes supernatant, big point of ultrafiltration removal The molecular cut off of sub- polysaccharide, ultrafiltration membrane is 40000Da, and ultrafiltration permeate is through the low-temperature vacuum drying (low-temperature vacuum drying For be 5 DEG C in temperature, vacuum degree 35kPa, drying time be 36 hours) obtain solid, solid is ground into 80 mesh fine powders, it is standby With；(2) balsam pear, mulberry leaf, campanulaceae, Chinese yam are taken, is cleaned, it is 8wt% to be dried at 28 DEG C respectively to water content, and mixing is ground into 80 The ultraviolet irradiation 1h that mesh fine powder is 254nm with wavelength sterilizes, spare；
Prepare papaya hardship mulberry composition：It takes the fine powder, rose hip witloof powder, auxiliary agent of (1) and (2) to be uniformly mixed to obtain kind Pawpaw hardship mulberry composition；
Tablet is made：Into papaya hardship mulberry composition be added maltodextrin be uniformly mixed, then add suitable quantity of water be made it is aqueous Amount is the softwood of 7wt%, and softwood is formed particle by 20 mesh screens, and it is 3wt%, warp that particle, which is dried at 50 DEG C to water content, Tablet press machine is pressed into piece, packaging to get.The mass ratio of the papaya hardship mulberry composition and maltodextrin is 1:1.It is per sheet weight 0.5g。
Embodiment 8
A kind of hypoglycemic papaya hardship mulberry tablet, including papaya hardship mulberry composition and dextrin are prepared.Described kind of wood Melon hardship mulberry composition includes that the raw material of following weight parts is prepared：
8 parts of papaya, 3.5 parts of balsam pear, 4 parts of mulberry leaf, 5 parts of campanulaceae, 5 parts of Chinese yam, 2.5 parts of rose hip witloof powder, auxiliary agent 0.5 Part.
The auxiliary agent is modified hickory kernel extract.
The preparation process of the papaya hardship mulberry piece, includes the following steps：
Pretreatment of raw material：(1) fresh papaya is taken, is cleaned, is dried at 28 DEG C to papaya surface moisture is removed, through grinding Mill obtains the slurry that granularity is 0.2mm, and slurry centrifuges 15min through 8000 revs/min of rotating speeds, takes supernatant, big point of ultrafiltration removal The molecular cut off of sub- polysaccharide, ultrafiltration membrane is 40000Da, and ultrafiltration permeate is through the low-temperature vacuum drying (low-temperature vacuum drying For be 5 DEG C in temperature, vacuum degree 35kPa, drying time be 36 hours) obtain solid, solid is ground into 80 mesh fine powders, it is standby With；(2) balsam pear, mulberry leaf, campanulaceae, Chinese yam are taken, is cleaned, it is 8wt% to be dried at 28 DEG C respectively to water content, and mixing is ground into 80 The ultraviolet irradiation 1h that mesh fine powder is 254nm with wavelength sterilizes, spare；
Prepare papaya hardship mulberry composition：It takes the fine powder, rose hip witloof powder, auxiliary agent of (1) and (2) to be uniformly mixed to obtain kind Pawpaw hardship mulberry composition；
Tablet is made：Into papaya hardship mulberry composition be added maltodextrin be uniformly mixed, then add suitable quantity of water be made it is aqueous Amount is the softwood of 7wt%, and softwood is formed particle by 20 mesh screens, and it is 3wt%, warp that particle, which is dried at 50 DEG C to water content, Tablet press machine is pressed into piece, packaging to get.The mass ratio of the papaya hardship mulberry composition and maltodextrin is 1:1.It is per sheet weight 0.5g。
Test case
(1) model case
(1) money, female, 51 years old
Suffer from diabetes and takes hypoglycemic always in existing 10 years, fasting blood-glucose 9.2mmol/L, postprandial blood sugar 15.7mmol/L Western medicine glibenclamide (glibenclamide), daily 5.0mg, although blood glucose substantially control, Urine proteins+or ++, usually metal fatigue, exerts oneself Adhere to routine work by force.The hypoglycemic papaya hardship mulberry tablet for adding embodiment 1 later 2 tablets each time, takes this product three times a day After a week, glibenclamide halves to daily 2.5mg, and it is normal to survey blood glucose；After taking this product 2 weeks, withdraw glibenclamide, it is normal to survey blood glucose； Continue after individually taking this product 30 days, surveys fasting blood-glucose 6.3mmol/L, postprandial blood sugar 7.2mmol/L, Urine proteins feminine gender, spirit Might as well, work does not think tired yet.
(2) certain is congratulated, man, 48 years old
Felt that appetite increases before 2 years, day is gradually thin, does not take notice of but, and rear physical examination discovery has suffered from diabetes, fasting blood-glucose 8.9mmol/L, postprandial blood sugar 13.4mmol/L, doctor say that the course of disease is estimated to be 2 years.Took the drop blood for adding embodiment 2 later Sugared papaya hardship mulberry capsule, three times a day, 2 tablets each time.Fasting blood-glucose 7.3mmol/L, postprandial blood sugar 11.7mmol/ are surveyed after a week L, fasting blood-glucose 5.6mmol/L, postprandial blood sugar 8.5mmol/L are surveyed after two weeks.Hereafter continuing to take this product, blood glucose is normal always, Physical condition is also fine.
(3) it is deep certain, man, 55 years old
It was found that suffering from fasting blood-glucose 9.1mmol/L when diabetes, postprandial blood sugar 14.4mmol/L, doctor says one section of illness Then time takes Acarbose 150mg daily, survey fasting blood-glucose 8.5mmol/L, postprandial blood sugar 13.5mmol/L, afterwards plus use pancreas Island element, every morning, 18 unit, surveyed fasting blood-glucose 6.8mmol/L, postprandial blood sugar 12.1mmol/L, deactivates insulin afterwards, changes and add The hypoglycemic papaya hardship mulberry capsule of embodiment 2 is taken, 3 times a day, 2 tablets each time, 1 surveys fasting blood-glucose 5.7mmol/L, meal after a week Blood glucose 8.2mmol/L afterwards.Withdraw Acarbose after 30 days, only take this product, later fasting blood-glucose maintains 5.5mmol/L or so, meal Blood glucose 8.0mmol/L or so afterwards.
(4) Sun, man, 51 years old
Suffer from diabetes 8 years, fasting blood-glucose 9.0mmol/L, postprandial blood sugar 17.0mmol/L, complicated hypertension, diastolic pressure 90, Systolic pressure 155, does not take depressor, takes Acarbose 150mg daily, unstable with postprandial blood sugar on an empty stomach after medication, has Shi Zhengchang, sometimes higher, blood pressure is higher always.Change the hypoglycemic papaya hardship mulberry tablet for taking embodiment 3 afterwards, 3 times a day, often Fasting blood-glucose 6.6mmol/L, postprandial blood sugar 9.1mmol/L after secondary 2,10 days, it is fasting blood-glucose 5.8mmol/L after 20 days, postprandial Blood glucose 7.6mmol/L, blood pressure is down to diastolic pressure 80, systolic pressure 135 after one month.After continue to take this product, blood glucose blood pressure is kept Normally, and stablize.
(5) Zeng, female, 51 years old
Suffer from diabetes 12 years, fasting blood-glucose 13.4mmol/L, postprandial blood sugar 19.4mmol/L are disorderly with gastrointestinal function Disorderly：Early satiety, gasteremphraxis, abdominal pain, constipation and skin itching scratch easy infection suppuration.Take gliquidone (Gliquidone) daily 90mg, 18 unit of insulin injection, fasting blood-glucose are controlled in 8.0mmol/L or so, postprandial blood sugar 11.0mmol/L or so, stomach and intestine Road and skin symptom have no improvement, after add the hypoglycemic papaya hardship mulberry tablet of embodiment 3,3 times a day, 2 tablets once, 10 days Fasting blood-glucose is down to 6.1mmol/L afterwards, postprandial blood sugar is down to 9.0mmol/L, and gastrointestinal tract and skin symptom make moderate progress, after 20 days Gliquidone and insulin are deactivated, continues to take this product, dosage is enlarged to 3 times a day, 3 tablets each time, fasting blood-glucose is surveyed after 30 days 5.3mmol/L, postprandial blood sugar 7.8mmol/L, gastrointestinal dysfunction symptom disappear, and feel that stomach and intestine are comfortable, defecation is unobstructed, skin disease Shape also disappears, and skin becomes bright and clean, also unconsciously itching.
(2) the hypoglycemic of mouse, lipid-lowering effect are tested
110 kunming mices are randomly divided into 1 Normal group (10), 9 experimental groups (every group 10) and 1 model Group (10).
It waits for that modeling mouse continuously gives high-sugar-fat-diet 3 days, after fasting 24 hours, alloxan (60mg/ is injected intraperitoneally kg).Continue to raise with high-sugar-fat-diet 7 days, the 7th day fasting 8h posterior orbit venous blood sampling, detaches serum, survey its blood glucose value > 20.0mmol·L-1Mouse modeling success, as model group.
Normal group and model group every morning 8:00 gives distilled water, the hypoglycemic papaya that experimental group gavage crushes Bitter mulberry tablet, given low 2g/kg.It is administered once daily, successive administration 20 days.Normal group gives basal feed, other Each group gives high-sugar-fat-diet, mouse free water during experiment, and feeding environment is 27 DEG C.20th day test blood glucose, blood fat Content.Test result is shown in Table 1,2.
Table 1：To the blood sugar influence result table of mouse
Blood glucose (mmol/L) before administration Blood glucose (mmol/L) after administration 20 days
Embodiment 3 22.84 17.65
Comparative example 1 22.62 20.45
Comparative example 2 22.73 21.28
Comparative example 3 22.25 20.63
Normal group 7.05 6.94
Model group 22.75 21.62
Each experimental group is compared with Normal group, △ P<0.05, each experimental group is compared with model group, △ P'<0.01.Respectively Test results compare, △ P " <0.05.
As it can be seen from table 1 compared with Normal group, model group, experimental mice blood glucose are significantly raised, illustrate modeling Success, after 20 days, the blood glucose level of the experimental mice of gavage papaya hardship mulberry piece is substantially reduced successive administration.
Contain multiple active enzymes in papaya, is aided with extract in balsam pear, mulberry leaf, campanulaceae, Chinese yam, it is right by scientific matching It is hypoglycemic to have good effect.The hypoglycemic papaya hardship mulberry tablet or capsule of the present invention, the balsam pear contained, mulberry leaf, campanulaceae, mountain Medicine and papaya synergistic effect can promote microcirculation, increase the effect of tissue keeping, vegetative cell, strengthen immunity, therefore, tool The effect of insulin receptor on nutritious and repair cell film restores sensibility of the receptor to insulin.
Balsam pear, mulberry leaf, campanulaceae, Chinese yam and papaya synergistic effect can eliminate pancreas islet chronic inflammation, decomposition leads to pancreas islet B The amylin of cellular atrophy and rupture removes sugar poison, eliminates insulin resistance.It is hypoglycemic to have the function that.
In addition papaya hardship mulberry piece, which contains specificity organized enzyme chymopapain and can cut off glucose and protein, relies knot The covalent bond of conjunction, makes glycosylated protein resolve into glucose and protein, restores original normal condition.Based on the above machine System makes to cause crystal egg under the action of the hypoglycemic papaya hardship mulberry tablet of the present invention or capsule specificity bioactive enzyme In vain, the glycosylation protein breakdown of collagen, elastin laminin and myelin protein denaturation keeps protein extensive at glucose and protein Multiple normal biological function.Therefore, papaya hardship mulberry piece can make angiocarpy, kidney, eyes, god caused by protein glycosylation It is controlled and alleviates through diabetic complications such as, ulcer of foot.Papaya hardship mulberry piece or capsule, which have effectively to decompose, glycosylates egg White matter function.
Table 2：To the lipid result table of mouse
Each experimental group is compared with Normal group, △ P<0.05, each experimental group is compared with model group, △ P'<0.01.Respectively Test results compare, △ P " <0.05.
From table 2 it can be seen that TC, TG, LDL-C value of the experimental mice of gavage papaya hardship mulberry piece are substantially reduced, HDL-C values increase, and illustrate that papaya hardship mulberry piece has blood fat reducing function.
(3) anticancer effect is tested
Experiment material：Castration-resistant prostate cancer cell strain PC3 is provided by Sun Yat-sen Memorial Hospital, with containing The F-12K culture mediums of 10% peptide cow's serum are cultivated.MTT (cell Proliferation and cytotoxicity) detection kit is purchased from the U.S. Sigma-Aldrich companies.
Cancer cell viability experiment：The PC3 cells of logarithmic growth phase are made cell suspension inoculation in 96 orifice plates, are connect per hole 190 μ L of kind, cell density are 5 × 103A/hole, wait for that cell is adherent makes the concentration of medicament reach 100 μ g/ to every hole addition medicament ML continues culture 24,48,72h, continues to cultivate 4h to every hole 10 μ LMTT solution of addition after cultivating the above-mentioned time, measures 570nm Locate absorbance (A) value.Difference lies in be added without medicament for blank group and experimental group.Cell viability (Cell viability, %) =(adding medicine group A values/blank group A values) × 100%.Experimental result takes the average value of 5 parallel laboratory tests.The preparation method of medicament For：It is added in 800mL water after papaya hardship mulberry piece 100g is crushed, is impregnated 12 hours at 35 DEG C, cross 800 mesh sieve, filtrate is existed 35 DEG C, 0.03MPa, 50 revs/min of condition rotary evaporations be concentrated into 200mL, obtain concoction.
Table 3：Cancer cell vigor test result table
As seen from the above table, hypoglycemic papaya hardship mulberry tablet of the invention or capsule also have the cancer cell vigor that reduces, suppression Growth of cancer cells processed and diffusion, improve the immunity of the human body, and can play anti-cancer and anticancer effect.
The preferred embodiment of the present invention has been described in detail above.It should be appreciated that those skilled in the art without It needs creative work according to the present invention can conceive and makes many modifications and variations.Therefore, all technologies in the art Personnel are available by logical analysis, reasoning, or a limited experiment on the basis of existing technology under this invention's idea Technical solution, all should be in the protection domain being defined in the patent claims.

Claims (10)

1. a kind of hypoglycemic papaya hardship mulberry tablet or capsule, including papaya hardship mulberry composition and dextrin are prepared, special Sign is that the papaya hardship mulberry composition includes that following raw materials are prepared：
Papaya, balsam pear, mulberry leaf, campanulaceae, Chinese yam.
2. hypoglycemic papaya hardship mulberry tablet according to claim 1 or capsule, which is characterized in that the papaya hardship mulberry Composition includes that the raw material of following weight parts is prepared：
5-10 parts of papaya, 1-5 parts of balsam pear, 2-6 parts of mulberry leaf, 3-7 parts of campanulaceae, 3-7 parts of Chinese yam.
3. hypoglycemic papaya hardship mulberry tablet according to claim 1 or 2 or capsule, which is characterized in that the dextrin is Cyclodextrin or maltodextrin.
4. hypoglycemic papaya hardship mulberry tablet according to claim 1 or 2 or capsule, which is characterized in that the papaya The mass ratio of bitter mulberry composition and dextrin is 1：(0.6-2.3).
5. the preparation process of hypoglycemic papaya hardship mulberry tablet according to claim 1 or 2 or capsule, which is characterized in that Include the following steps：
(1) pretreatment of raw material：(1) fresh papaya is taken, is cleaned, is dried or dry, then starched through crushing or grinding Material, slurry take supernatant through centrifuging or squeeze, and ultrafiltration removes macromolecular polysaccharide, and ultrafiltration permeate is through low-temperature vacuum drying or cold Jelly is dried to obtain solid, and solid is ground into fine powder, spare；(2) balsam pear, mulberry leaf, campanulaceae, Chinese yam are taken, is cleaned, is dried or dry Dry, mixing is ground into fine powder, sterilizes, spare；
(2) papaya hardship mulberry composition is prepared：It takes the fine powder of (1) and (2) to be uniformly mixed and obtains papaya hardship mulberry composition；
(3) tablet or capsule is made.
6. the preparation process of hypoglycemic papaya hardship mulberry tablet according to claim 5 or capsule, it is characterised in that：It is described Tablet, which is made, is：Into papaya hardship mulberry composition plus dextrin is uniformly mixed, and adds suitable quantity of water that softwood is made, softwood is passed through 20- 30 mesh screens form particle, by particle at 40-50 DEG C it is dry after through tablet press machine be pressed into piece, packaging to get.
7. the preparation process of hypoglycemic papaya hardship mulberry tablet according to claim 5 or capsule, it is characterised in that：
The capsule that is made is：Into papaya hardship mulberry composition plus dextrin is uniformly mixed, and is directly loadable into using capsule filling machine Capsule, packaging to get.
8. the preparation process of hypoglycemic papaya hardship mulberry tablet according to claim 5 or capsule, which is characterized in that step (1) described dry is dried at 25-30 DEG C to papaya surface moisture is removed, and step (1) drying is dried at 25-40 DEG C To removing papaya surface moisture, it is that be dried at 25-30 DEG C to water content be 6wt%-10wt%, step that step (2) is described, which to dry, Suddenly (2) described drying is that water content is dried at 25-40 DEG C as 6wt%-10wt%.
9. the preparation process of hypoglycemic papaya hardship mulberry tablet according to claim 5 or capsule, which is characterized in that described The granularity of slurry is 0.2-0.3mm.
10. the preparation process of hypoglycemic papaya hardship mulberry tablet according to claim 5 or capsule, which is characterized in that institute The molecular cut off for stating ultrafiltration membrane is 20000-50000Da.
CN201810945894.XA 2018-08-20 2018-08-20 Hypoglycemic papaya hardship mulberry tablet or capsule and its preparation process Pending CN108704052A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810945894.XA CN108704052A (en) 2018-08-20 2018-08-20 Hypoglycemic papaya hardship mulberry tablet or capsule and its preparation process

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810945894.XA CN108704052A (en) 2018-08-20 2018-08-20 Hypoglycemic papaya hardship mulberry tablet or capsule and its preparation process

Publications (1)

Publication Number Publication Date
CN108704052A true CN108704052A (en) 2018-10-26

Family

ID=63873734

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810945894.XA Pending CN108704052A (en) 2018-08-20 2018-08-20 Hypoglycemic papaya hardship mulberry tablet or capsule and its preparation process

Country Status (1)

Country Link
CN (1) CN108704052A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110496183A (en) * 2019-09-30 2019-11-26 仲建福 A kind of concentration piece and preparation method thereof for treating diabetes

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1698871A (en) * 2005-05-25 2005-11-23 北京华昱安然医药科技有限公司 Health product for assisting blood sugar-decreasing function and its preparation method
CN102599488A (en) * 2011-01-20 2012-07-25 吴金华 Preparation method of Kusangguo tablets
CN103142675A (en) * 2013-03-13 2013-06-12 孙今雄 Blood sugar reducing traditional Chinese medicinal herb
CN106074971A (en) * 2016-07-13 2016-11-09 湖北中医药大学 A kind of hypoglycemic traditional Chinese medicine composition and preparation method and application

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1698871A (en) * 2005-05-25 2005-11-23 北京华昱安然医药科技有限公司 Health product for assisting blood sugar-decreasing function and its preparation method
CN102599488A (en) * 2011-01-20 2012-07-25 吴金华 Preparation method of Kusangguo tablets
CN103142675A (en) * 2013-03-13 2013-06-12 孙今雄 Blood sugar reducing traditional Chinese medicinal herb
CN106074971A (en) * 2016-07-13 2016-11-09 湖北中医药大学 A kind of hypoglycemic traditional Chinese medicine composition and preparation method and application

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
高玲,等: "木瓜苦桑片对Ⅱ型糖尿病大鼠的影响", 《中国实验方剂学杂志》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110496183A (en) * 2019-09-30 2019-11-26 仲建福 A kind of concentration piece and preparation method thereof for treating diabetes

Similar Documents

Publication Publication Date Title
CN102428832B (en) Fungal pharmaceutical mycoplasm with blood sugar lowering efficacy and preparation method thereof
CN102697035A (en) Cordyceps anti-aging pellet
CN101612315A (en) A kind of compound Chinese medicinal preparation that is used to adjust function of human body
CN108524814A (en) A kind of Chinese medicine composition and preparation method thereof for reducing blood glucose
CN103405577B (en) The Pharmaceutical composition of a kind of enhancing immunity, fatigue alleviating
WO2021078288A1 (en) Activated insulin, compound momordica charantia peptide oral medicine for treatment of diabetes, and preparation method
CN104857154A (en) Traditional Chinese medicine composition for treating three-high diseases and preparation method therefor
CN107537028B (en) Formula for simultaneously assisting in reducing blood sugar and blood pressure and preparation method thereof
CN108815230A (en) Chinese medicine composition and its preparation method and application for treating diabetes
CN108704052A (en) Hypoglycemic papaya hardship mulberry tablet or capsule and its preparation process
CN106581166A (en) Anti-fatigue food, health product or pharmaceutical composition
CN114869923B (en) Water-soluble extract of national medicine double ginseng, preparation method and application thereof
CN1565467A (en) Use of cornel and its extract in preparation alpha-glucosidase inhibitor medicine
CN107812115A (en) A kind of Chinese medicine composition for treating diabetes
CN113082106A (en) Compound composition, application of compound composition in preparation of medicine for treating diabetic complications and medicine for treating diabetic complications
CN106344829A (en) Traditional Chinese medicine composition and production method thereof
CN1243443A (en) Fresh rehmannia root extract for proliferating bifidobacteria and extraction method thereof
CN109123655A (en) A kind of special doctor&#39;s food and preparation method with three high crowd&#39;s generation meal regulatory functions
CN1273093A (en) Hypoglycemix Xinxuekang and itspreparing process
CN113521186B (en) Hypoglycemic drug and preparation method and application thereof
CN115671219B (en) Traditional Chinese medicine composition for treating gout and preparation method and application thereof
CN117981877B (en) Anti-alcohol liver-protecting composition and application thereof
CN108578578A (en) A kind of pharmaceutical composition and preparation method thereof
CN107397776A (en) A kind of Chinese medicine composition for treating disease in the liver and gallbladder and preparation method thereof
CN102823867A (en) Health-care food capable of repairing functions of damaged islet cells

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20181026