CN1326771A - Medicine for curing diabetes - Google Patents

Abstract

The medicine is prepared with 11 kinds of Chinese medicinal materials including ginseng, Astragalus membranaceus, Atractylodis Macrocephalae, etc. It has high diabetes curing rate and effective rate and no toxic side effect.

Description

A kind of treatment diabetes medicine

The present invention relates to a kind of treatment diabetes medicine, the Chinese medicine preparation that particularly a kind of prepared from traditional Chinese medicines forms.

Diabetes are the third-largest diseases that influence human health and life that are only second to cardiovascular diseases and tumor in the world today.Its sickness rate and economic development degree, mental and blue-collar ratio, dietary structure is accustomed to, and factors such as heredity, geographical environment are relevant.In China, according to diabetes study cooperative groups statistics, average attack rate has 10.15 ‰ at least, and the old people's sickness rate more than 60 years old is up to more than 43.34 ‰.

Diabetes are absolute or relative deficiency of insulin that various factorss such as a class heredity, environment, immunity cause, are its endocrine metabolism disease that mainly shows with tangible chronic hyperglycemia and glycosuria.Its basic Pathophysiology be since in the body hormone of insulin deficit or antagonism insulin increase, or insulin can not be brought into normal play physiological action and a kind of syndrome of the glucose, protein and the lipid metabolic disorder that cause in target cell.It is characterized by unusual rising of concentration of glucose and glucose in urine in the blood circulation, occur typical three-many-one-little symptom when blood glucose is too high, i.e. polydipsia, polyuria, polyphagia and lose weight, and with fatigue and weak.When serious ketoacidosis, hypertonicity diabetic coma can take place, and easily merge multiple infection.Prolongation along with the course of disease, its metabolism disorder can cause the chronic progressive external disease of histoorgans such as eye, kidney, nerve, blood vessel and heart to become, if can not get appropriate treatment in time, heart change, cerebrovascular disease, renal failure then can take place, lose the sight of both eyes, lower limb gangrene etc. and the deadly major cause of morbidity that becomes.

For the ease of treatment, clinically usually diabetes are further sorted out.Simplified revised standard according to WHO in 1980 at present, diabetes are divided into four classes: (1) insulin dependent diabetes mellitus (IDDM) (claiming type i diabetes again) is abbreviated as IDDM.(2) non-insulin-dependent diabetes mellitus (claiming type ii diabetes again) is abbreviated as NIDDM.(3) gestational diabetes.(4) other types diabetes (claiming secondary diabetes again) comprise following disease or the situation of being secondary to: pancreatic diseases, endocrinopathy, medicine or chemicals, unusual, some genetic syndrome of Insulin receptor INSR.Preceding clinically two classes are more sees, back two classes are more rare.

At present, doctor trained in Western medicine clinical treatment medicine mainly contains insulin type, sulphur urine class, biguanides.

Though one, insulin type does not have contraindication, have no side effect, certain limitation is arranged, have following situation person to use:

1, insulin type dependent diabetes: patient self beta Cell of islet synthesis secretion insulin defectiveness, therefore the ill later exogenous insulin survival that needs to rely on needs lifelong insulinize.

2, non-insulin-dependent diabetes mellitus: these diabetes must be accepted insulinize when following situation takes place: through diet control and oral hypoglycemic drug therapy, the state of an illness still can not be controlled (1), and therapeutic effect is poor.(2) ketoacidosis or occur ketosis, non-ketosis hyperosmolar coma, lactate repeatedly and poison.(3) diabetic retinopathy.(4) diabetic nephropathy occurs after the urine protein.Malabsorption syndrome etc. seriously diarrhoea appears, in (5) diabetic neuropathy.(6) trimester of pregnancy.(7) emergency rating.(8) liver, renal insufficiency.(9) merge the disease that needs adrenocortical hormones in treating simultaneously.(10) obviously become thin, body weight is lower than 90% of standard body weight.

3, malnutrition type diabetes.

Two, the untoward reaction of sulphur urine class medicine:

1, hypoglycemic reaction: common dizziness, nervous, weak etc., angina pectoris or the myocardial infarction that often can bring out patients with coronary heart disease can cause that also cerebrovascular accident takes place.

2, symptom of digestive tract: the minority case has epigastric discomfort, feels sick, loss of appetite etc.

3, blood system: first generation sulphur urine class medicine can temporaryly cause the minimizing of hemocyte, accounts for only a few but hemolytic anemia takes place, and is then more rare with second filial generation sulphur urine class medicine.

4, anaphylaxis: idol has skin urticaria etc.

Three, the untoward reaction of biguanides:

1, digestive tract reaction: account for 10%-30%, show as abdominal discomfort, gastrointestinal dysfunction, diarrhoea, feel sick, vomiting and loss of appetite etc.

2, lactic acidosis: the insoral consumption surpasses 100 milligrams or old-aged diabetic every day, liver, renal insufficiency, and lactate easily takes place and poisons in the heart, pulmonary disease and anoxia etc.

The object of the present invention is to provide and a kind ofly can effectively treat the diabetes medicine, effective percentage and cure rate height.

The present invention is achieved in that

A kind of treatment diabetes medicine, it is characterized in that it is that medicine by the following weight proportioning is made: Radix Ginseng 6-9, the Radix Astragali 15-30, the Rhizoma Atractylodis Macrocephalae 15-20, Fructus Lycii 15-20, Rhizoma Polygonati 15-30, Fructus Corni 15-20, Radix Ophiopogonis 15-30, Rhizoma Dioscoreae 24-50, Radix Rehmanniae 24-50, Radix Trichosanthis 24-60, Rhizoma Coptidis 8-12.

After the present invention adopts such scheme,, make insulin level increase in its blood plasma, suppress the glycogen heteroplasia and produce blood sugar reducing function, improve carbohydrate tolerance with promoting glycolysis by activating β emiocytosis insulin.Can effectively treat diabetes, cure rate reaches more than 90%, effective percentage 100%.Because of being that Chinese herbal medicine is made all, without any side effects, taking convenience, instant effect.

Medically, diabetes have the branch of primary diabetes mellitus and secondary diabetes, constitutional accounts for the overwhelming majority and its reason does not still have final conclusion, and Secondary cases accounts for only a few, mainly be the hormone secretion that causes islet tissue infringement or islets of langerhans is have an antagonism by other diseases too much due to.Also by the degree of dependence of this disease, it is divided into insulin-dependent (type i diabetes) and two types on non-insulin-dependent type (type ii diabetes) clinically to insulin.

The typical clinical symptom of diabetes can be summarised as " three-many-one-little " simply, promptly polyphagia, polyuria, polydipsia, lose weight.

Polyphagia: the traditional Chinese medical science thinks that the scorching increased functionality of diabetes involving middle-JIAO mill water paddy that makes causes in the stomach.Doctor trained in Western medicine thinks that insulin secretion reduces or takes place after the insulin resistant that sugar can not get normal the utilization and metabolism in the body, thereby each tissue of health can not get required energy, will impel the emptying reinforcement of stomach by neural feedback effect.

Polyuria: the traditional Chinese medical science is thought deficiency of kidney-QI, and deficiency of the kidney causes due to astringency inducing haves no right.Doctor trained in Western medicine think since in the blood concentration of glucose too high, the sugar of discharging through kidney surpasses the heavy absorbability of kidney, thus sugar by kidney with the urine discharge.Sugar is discharged when too much, carry part moisture, forms polyuria like this.General glucose in urine is many more, and the urine amount is also just many more.

Polydipsia: the traditional Chinese medical science thinks that due to the Yin and fluid deficiency, because increases of urinating lacks moisture in the health, nature will feel thirsty and great quantity of water drinking, with the additional moisture of losing because scorching in the lung.

Lose weight: sugar is not used in the body, discharge by urine continuously, absorb the sugar of coming by polyphagia by digestive tract, because insufficient insulin or insulin resistant in the body and can not get effect equally, be the required energy of the activity of earning a bare living, health is just had to decompose protein and the fat self stored and is supplied with.Protein is the main component of muscle, and fat plentiful health be unable to do without fat.Along with the continuous consumption of protein, fat, health is become thin gradually, loses weight.

The chemical constituent of Radix Ginseng among the present invention: 1, Saponin class: kind surplus having isolated 30 altogether comprises oleanolic acid group (ginsenoside R ₀), protopanoxadiol group, Protopanaxatriol group.2, nitrogen-containing compound: comprise 17 seed amino acids such as asparagine, threonine, serine, glutamic acid, adenosine triphosphate, adenosine, polypeptide, choline, ketopyrrolidine ammonia.3, vitamins: comprise vitamin B1, B2, B12 and C, folic acid, biotin, nicotinic acid, pantothenic acid and nicotiamide.4, kind surplus the volatile ingredient 70, organic acid comprises 15 kinds of citric acid, 1-Hydroxy-1,2,3-propanetricarboxylic acid., ketoglutaric acid, malic acid, diaspirins etc., 6 kinds of ester such as triglyceride etc.5, kind surplus trace element such as copper, zinc, ferrum, the manganese etc. 20.6, flavonoid: as nimbecetin, trifolin and panasenoside.7, saccharide: comprise monosaccharide such as fructose, glucose, xylose, mannose etc.; Disaccharidase such as sucrose, maltose; Trisaccharide such as Raffinose; And polysaccharide.Radix Ginseng contains 38.7% water soluble polysaccharide and 7.8%-10.0% alkaline soluble polysaccharide.Wherein about 80% is Radix Ginseng starch, and 20% is the ginseng pectin, is glycoprotein on a small quantity.Its pharmacological action: 1, to carbohydrate metabolism: Radix Ginseng has two-way Accommodation to blood glucose, can make that glucose reduces in the blood of rising, and the glucose that has reduced in the blood is raise.But not influence of blood glucose to normal level.Radix Ginseng is comparatively complicated to glycometabolic influence.Different Saponin units, metabolism is all influenced to some extent, and the influence of animal food composition and content is also bigger as PDG3-2 as Rb1, Rg1 and non-Saponin part.Radix Ginseng contains the Acid polypeptide of ribosidoadenine and 14 seed amino acids composition, is not easy by stomach acids destroy.These compositions can be to the effects of antiadrenergic drug, ACTH and pancreas hyperglycemia and are strengthened insulin to glycometabolic influence.Radix Ginseng component GN3 all can reduce the blood glucose of normal rat and excision adrenal gland rat; Known insulin can promote that glucose is transformed into fat.2, to the experiment diabetes: Radix Ginseng has the normalization effect to blood glucose; dual regulation in other words; the glucose that raises in the blood is reduced; the low blood glucose that insulin injection is caused raises; and can stop alleviating of alloxan diabetes rats body weight; sugar content is reduced, diabetes rat survive time lengthening.Radix Ginseng can stimulate the mice islets of langerhans uelralante that dissociates, and the insulin synthetic quantity is obviously increased.Radix Ginseng extract has hypoglycemic effect to alloxan diabetes, and can reduce ketoboidies, promotes the effect that sugar absorbs.Radix Ginseng total saponins can stimulate isolating rat Langerhans islet uelralante, and the insulin that promotes glucose to cause discharges.Dose-response relationship curve between Radix Ginseng total saponins and insulin discharge is serpentine.The panaxosideRb2 has facilitation to the protein synthesis of the diabetes due to the streptozotocin, extract in the non-Saponin part of Radix Ginseng and obtain blood sugar reducing component DPG3-2, also can promote the mice pancreatic uelralante, improve content of insulin in the blood, 4mg/ml can make heritability diabetic mice Lan Shi island insulin free in a large number.Hypoglycemic mechanism to polypeptide discovers that the ginseng polypeptide hypoglycemic activity promotes glycogenolysis except it or suppress mainly due to the activity that has stimulated SDH and CCD, to make the enhanced cause of aerobic oxidation effect of sugar the synthetic hepatic glycogen effect of lactic acid.The ginseng polysaccharide can make propionic acid content increase, and suppresses lactic acid dehydrogenase activity lactic acid is reduced, and can increase the activity of succinate dehydrogenase (SDH) and cytochrome oxidase, reduce and hang down for polysaccharide content in the age HELF, to height for the increase effect is then arranged age.Therefore, no matter Radix Ginseng natural products, first extract, polysaccharide, polypeptide, Saponin or non-saponin component, all has hypoglycemic activity in various degree, and its action range, the hyperglycemia due to chemical diabetes, heritability diabetes, stress hyperglycemia and the direct injection glucose all there is certain effect.

The chemical constituent of the Radix Astragali among the present invention: from Radix Astragali, isolate astragalin I, astragalin II, daucosterol, β-sitosterol, Palmic acid, sucrose, astramembrangenin, kumatakenin, choline, betanin, folic acid, calycosin, the handle florigen and be the astragalin of glycoside unit of ruing with the triterpene Cycloastragenol, and antimicrobial component L-3-hydroxyl-9-methoxy Lignum pterocarpi indici alkane, glucuronic acid, phlegmatic temperament, aminoacid, bitter principle etc.The contained Saponin class of Radix Astagali is similar to Radix Astragali, but contained other compositions horn of plenty more.Comprise astragalus polysaccharides I, II, III as polysaccharide, glucose AG-1 and AG-2 heteropolysaccharide AH-1 and AH-2, flavonoid comprise target handle xanthin, Mao Ruiyi ketone and multiple glycoside, methoxyl group Lignum pterocarpi indici alkane; Amino acids comprises 21 kinds of N, canavanine, proline, gamma-aminobutyric acids etc.; Inorganic constituents comprises 14 kinds of trace element such as ferrum, manganese, zinc, rubidium.Other also contains β-sitosterol, sucrose, linoleic acid, linolenic acid, betanin, Vp, starch etc.Its pharmacological action: to the influence of glucose metabolism: the big hepatic glycogen content due to Radix Astragali injection abdomen injection can the obviously reduction the in advance noise obviously increases, and the Radix Astragali rising blood sugar level institute trend is arranged, but increase rate is less to islets of langerhans disposition hypoglycemia animal.Illustrate that the Radix Astragali may have dual regulation to blood glucose.Astragalus decoction is irritated stomach the biosynthetic rate-limiting enzyme methylol of cholesterol glutaraldehyde CoA-reductase (HMGR) in hepatocyte microsome and the mucous membrane of small intestine homogenate is economized slightly obviously inhibitory action, but the concentration of the pure and mild high density lipoprotein gallbladder of the total gallbladder of serum alcohol is not had obvious influence.

The chemical constituent of the Rhizoma Atractylodis Macrocephalae among the present invention: contain 1.4% volatile oil approximately, its main component is atractylone, atractylol, selinene, sesquiterpene lactones chemical compound Rhizoma Atractylodis Macrocephalae lactone I, II, III and 8-β-ethoxy Rhizoma Atractylodis Macrocephalae lactone etc.The clear and definite structure of acetylene compound in the Rhizoma Atractylodis Macrocephalae have 8 kinds.Also contain vitamin in the Rhizoma Atractylodis Macrocephalae.Its pharmacological action: blood sugar lowering: rabbit gavages decoct or preserved material, and blood glucose has the Rhizoma Atractylodis Macrocephalae decoct of reduction or preserved material to give rat oral gavage slightly, and hypoglycemic activity is also arranged.As giving rabbit with Rhizoma Atractylodis Macrocephalae extractum subcutaneous injection, significantly hypoglycemic activity appears at 2-5 hours, reduces by 40% before the comparable administration.Its principle is blood sugar lowering by the assimilation of glucose in the acceleration bodies.Rhizoma Atractylodis Macrocephalae Jian agent has the liver protecting, prevents the hepatic glycogen minimizing effect that carbon tetrachloride causes mice.

The chemical constituent of Fructus Lycii among the present invention: mainly comprise sulphuric acid amine element, sulfur ammonia mortifier, carotene, riboflavin, nicotinic acid, ascorbic acid, cupreol, linoleic acid, zeaxanthine, betanin, Calyx seu fructus physalis arnotto fruit, kryptoxanthin, atropine, hyoscyamine, scopoletin, aminoacid and trace element.Its pharmacological action: blood sugar lowering: the lycium barbarum seed extract can make rat blood sugar reduce significantly and lastingly, and rat raises to the tolerance of carbohydrate, and its hypoglycemic effective ingredient is its contained guanidine derivatives.

The chemical constituent of Rhizoma Polygonati among the present invention: contain polygonatum polysaccharide first, second, third and Rhizoma Polygonati low sugar first, second, third, and huangjinoside A, B, Neoprazerzerigenin, 3-O-β-lycoteraosideeye and the homologue of methyl prototype thereof also contain 11 seed amino acids such as lysine.Wherein polygonatum polysaccharide forms by glucose, mannose, galacturonic acid condensation, and the oligosaccharide first is formed by 8 molecule fructose and 1 molecule glucose condensation, and oligosaccharide is formed by 2 molecule fructose and 1 molecule glucose condensation.The Yunnan Rhizoma Polygonati also contains kingianoside A, B, C.Its pharmacological action shows as the influence to blood glucose: gavage to rabbit with Rhizoma Polygonati extractum, its blood glucose raises earlier and afterwards reduces, blood glucose increment rate and action time all are directly proportional to the dosage of Rhizoma Polygonati extractum, to the blood glucose due to the epinephrine is too high obvious inhibitory action arranged, methanolic extract is injected on an empty stomach, to the diabetes that normal mouse and streptozotocin bring out, back 4 hours blood glucose of injection is descended, the mice hyperglycemia that epinephrine is brought out is also effective.

The chemical constituent of Fructus Corni among the present invention: 1, volatile ingredient: comprise 9 kinds of monoterpenes, 6 kinds of fatty aldehydes, 5 kinds of aliphatic hydrocarbons, 7 kinds of acid, and 8 kinds of esters and 5 kinds of aromatic compounds.Wherein main component has Palmic acid, benzyl cinnamate, isoamyl alcohol, trans-Epoxydihydrolinalool, elemicin, furfural, methyleugenol, different asarone, β-phenethanol.2, glucoside and glycoside unit comprise cornin, morroniside, sweroside, Semen Strychni glycoside, ursolic acid, iridoid lamp, and glucose, fructose, sucrose are still arranged in the fruit.3, kind surplus tannin has ten is as Lay wood tannin etc.4, other are as gallic acid, malic acid, tartaric acid, vitamin A etc.Its pharmacological action mainly shows as and reduces sugar: the Fructus Corni tannic acid can suppress lipid peroxide and stop steatolysis, suppresses the decomposition that epinephrine and adrenocortical hormone promote fat, helps controlling the generation of hyperglycemia.Experiment confirm, the cornusol extract must have obvious blood sugar reducing function by diabetes rat to alloxan, chain urine assistant bacterium and epinephrine.Fructus Corni powder, the further isolating pier fruit acid of ether extraction agent, ursolic acid and other three subfractions are measured blood glucose, glucose in urine, amount of drinking water and displacement.The equal powder of result, ether extraction agent and ursolic acid be the obvious blood sugar lowering of energy, glucose in urine, amount of drinking water and voided volume all, and the prompting ursolic acid is a Fructus Corni diabetes active component.Epididymal adipose experiment with rat finds that Fructus Corni has ILA.But most experiments confirmation Fructus Corni and composition thereof do not have influence to intact animal's blood glucose.

The chemical constituent of Radix Ophiopogonis among the present invention: mainly comprise saccharide, steroidal class and homoisoflavone class.Wherein: saccharide mainly contains glucose, D-galactose, sucrose and Radix Ophiopogonis oligosaccharide first, second, Radix Ophiopogonis polysaccharide.Steroidal and steroidal glycoside such as β-sitosterol, stigmasterol, campesterol and glucoside thereof, Radix Ophiopogonis saponin, the pre-sapogenin of potato, 3-O-α-L-pyrans Lee sugar ,-(1-2)-β-D-pyrrole Lignum nanmu sugar ,-tens of kinds of (1-3)-β-D-Glucopyranose .s etc.Homoisoflavone class such as ware methylophiopogonanone first, second, methylophippogonone first, second, Radix Ophiopogonis ketone first, second, kind surplus the different Radix Ophiopogonis ketone first-class ten.Other still contain N-2-(P-hydroxy phenyl)-2-hydroxyethyl-trans-P-amide, 1-Borneolum Syntheticum-β-D-glucoside, Borneolum Syntheticum-6-O-β-D-apiose-β-D-glucoside, Borneolum Syntheticum sulfuric acid ester calcium etc.Its pharmacological action: to blood glucose, Radix Ophiopogonis, alcohol extract can reduce normal rabbits blood glucose, irritate stomach with 0.5% (kg.d) dosage, continuous 4 days, as seen alloxan diabetes man rabbit blood glucose reduces, and can impel islet cells form, function to recover to some extent, and hepatic glycogen also has the trend of increase.But with 50% Radix Ophiopogonis decoct intramuscular injection 1ml/kg, find medication rabbit blood sugar increasing, this is relevant with the contained mono-and di-saccharides of Radix Ophiopogonis.From clinically, Radix Ophiopogonis hypoglycemic effect generally should be sure.

The chemical constituent of Rhizoma Dioscoreae among the present invention: the tuber of Rhizoma Dioscoreae contains dioscin, phlegmatic temperament, gallbladder, starch, glycoprotein, free amino acid, ends power element, vitamin C, and 3,4-dihydroxy benzenes ethamine contains mannan and phytic acid in the mucus.Its pharmacological action: the amount of Rhizoma Dioscoreae water decoction 30g/kg or 60g/kg is given mouse gavaging, 10 continuous skies can make normal mouse blood glucose reduce, mice diabetes due to the alloxan there are prevention and treatment dual function, also can raise antiadrenergic drug or the caused mouse blood sugar of injectable dextrose monohydrate.

The chemical constituent of Radix Rehmanniae among the present invention: the main component of Radix Rehmanniae is tens of kinds of iridoid, monoterpene and Corallium Japonicum Kishinouye glycoside thereof, close Z-TEK glycoside, rehmannioside, geniposide, ajugoside, daucosterols etc.Saccharide also contains special manyly in the Radix Rehmanniae, as stachyose, Raffinose, glucose, sucrose, fructose, mannotriose, verbascose, galactose, D-glucamine.It is multiple to contain 20 aminoacid in the Radix Rehmanniae, and wherein smart amino acid content is the highest; Contain 5 kinds of amino acid/11s in the Radix Rehmanniae, wherein alanine content is the highest.Also contain in addition 20 various trace elements such as ferrum, zinc, manganese, chromium and 20 I plant organic acid such as benzoic acid, phenylacetic acid, sad, n-nonanoic acid, cinnamic acid etc., also have β-sitosterol, a spot of stigmasterol, D-mannitol, phosphoric acid etc.Its pharmacological action: subcutaneous injection Radix Rehmanniae alcohol extractum can make rabbit blood glucose descend, and can also suppress the persistency hyperglycemia that Radix Angelicae Sinensis institute carbohydrate containing causes, can suppress or prevent the rabbit blood glucose rising due to the adrenal gland.The rehmanin subcutaneous injection has similar blood sugar decreasing effect.Its blood sugar lowering partly is named as R-BP-F, can represent the hypoglycemic activity of Radix Rehmanniae, and its main component is a catalpol.

The chemical constituent of Radix Trichosanthis among the present invention: the Radix Trichosanthis main chemical compositions comprises several classes such as protein, polysaccharide, enzyme, aminoacid, lectins.1, protein karasurin and α-Momorcharin and β-Momorchin.Be present in the radices trichosanthis.2, polysaccharide: THFPS is a kind of thermal source, and tangible immunoregulation effect is arranged, and energy enhance immunity activity has remarkable anti-tumor activity and cytotoxic activity.Polysaccharide is isolated 5 glucose, radices trichosanthis polysaccharide A, B, C, D and E with hypoglycemic activity mainly by isolating a kind of new heteropolysaccharide in the radices trichosanthis natural juice from water extract.3, enzyme: have multiplely, wherein β-galactoside enzymatic activity is the strongest, and α-mannoside enzymatic activity is taken second place.4, aminoacid: except that containing a large amount of free citrulline, also contain alanine, valine, tyrosine, lysine, gamma-aminobutyric acid, two hydration citrulline, α-methylol serine etc.Other are also isolated by three bonded lectinses of galactose, chondrillasterol, reach glycoside, Palmic acid etc.Its pharmacological action: Radix Trichosanthis and ingredient thereof have pharmacological action more widely.To blood glucose, the non-permeate portion of radices trichosanthis water extract has the blood sugar lowering activity, wherein comprises five polysaccharide: TrichosanA, B, C, D, E.To after mouse peritoneal injection TrichosanA, B, C, D, E7 hour for outstanding hypoglycemic activity being arranged by the inductive hyperglycemia mice of alloxan, and present dose-dependence.

The chemical constituent of Rhizoma Coptidis among the present invention: mainly be berberine, i.e. berberine, content is 7%-9%.Other are as coptisine, 13-methyl-.psi.-coptisine., palm leaf coculine, paAlmatine, jateorhizine, cypress ketone, obakulactone.Phenoloid has magnoline, ferulic acid, the stupid ethanol glycoside of 3,4-dihydroxy, the stupid basic glycoside of 3-hydroxyl-4-hydroxyl.Rhizoma Coptidis also contains various trace elements in addition.Its pharmacological action shows blood sugar lowering: Rhizoma Coptidis decoct 1g/kg irritates stomach to normal mouse, its blood glucose is descended, and certain dose-effect relationship is arranged.With 10,40,80 and the berberine of 120mg/kg give mouse gavaging, find that 40kg promptly has the effect of obvious reduction normal mouse blood glucose, also be tangible dose-effect relationship, also can resist the hyperglycemia due to mouse peritoneal injectable dextrose monohydrate or the epinephrine.50mg (kg.d) berberine can reduce the alloxan mouse blood sugar, to spontaneous diabetes KK mouse gavaging berberine 15 days, its sugar is descended, and glucose tolerance improves.Berberine does not influence secretion of insulin and release, does not influence liver plasma membrane Insulin receptor INSR number and affinity yet, but can to suppress with the alanine be the gluconeogenesis of substrate, and the rising of its hypoglycemic activity and blood lactic acid is closely related.Therefore, berberine is by suppressing gluconeogenesis and promoting that glycolysis produces hypoglycemic activity.

In sum, its origin cause of formation of diabetes is nothing more than the deficiency of YIN and red-hot two aspects, and reciprocal causation.Contained according to " medical science innermost thoughts and feelings ": " person of disappearing in the big ruling by law, its lung of Yi Run, clear its stomach of holding concurrently; The person of disappearing in controlling, clearing stomach is held concurrently and is grown its kidney; Control the inferior the person of disappearing, should grow its kidney, hold concurrently and mend its lung." so use Radix Ophiopogonis, Radix Rehmanniae, Radix Trichosanthis, clearing heat and moistening dryness, promoting the production of body fluid to quench thirst, with Rhizoma Coptidis, Radix Rehmanniae eliminating stomach-fire, with Fructus Lycii, Rhizoma Polygonati, the cloudy the kidney invigorating of Fructus Corni, Radix Ginseng, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae are to protect taste, benefiting qi and raising yang.Each medicine share plays clearing heat and moistening dryness altogether, enriching yin and nourishing kidney, and treating both the principal and secondary aspects of a disease is to reach the blood sugar lowering effect.

Below in conjunction with embodiment the present invention is elaborated.

Get Radix Ginseng 6 grams, the Radix Astragali 15 grams, the Rhizoma Atractylodis Macrocephalae 15 grams, Fructus Lycii 15 grams, Rhizoma Polygonati 15 grams, Fructus Corni 15 grams, Radix Ophiopogonis 15 grams, Rhizoma Dioscoreae 24 grams, Radix Rehmanniae 24 grams, Radix Trichosanthis 24 grams, Rhizoma Coptidis 8 grams are put into marmite, add cold water soak 1 hour.Be fried boiling with high heat earlier, reuse is at a simmer during to 500 milliliters of surplus approximately medicinal liquids, filters; Medicinal residues add 1000 milliliters of hot boiled water again, continue at a simmerly to filter during to 500 milliliters of surplus approximately medicinal liquids, and twice medicinal liquid merges, and about 1000 milliliters of gained medicinal liquid can be taken.

Instructions of taking: every day, potion was 1000 milliliters, and medicinal liquid is divided into 2 parts, and 500 milliliters every part, each clothes is a on an empty stomach sooner or later.Serveing on 3 months is a course of treatment.

Clinical trial:

Medicine of the present invention has carried out following clinical trial in second the People's Hospital, Donga, Shandong Province county on February 2, March 15 to calendar year 2001 in 2000, treats 150 examples altogether, male 76 people, women 24 people, the course of disease the shortest 2 months, the longest 10 years (exceeding with the time of finding).At minimum 18 years old of age, maximum 60 years old, divide two groups of A, B at random, every group 75 people; The above-mentioned decoction of A group clothes, every day potion, decocting 2 times divides and takes for 2 times; Observe the curative effect after serveing on three months; The treatment of B group clothes glyburide, amount treatment is routinely observed after serveing on three months.Treat preceding 4 weeks, checked continuous 3 times of fasting glucose, glucose in urine (quantitative or qualitative) every 10-14 days, 3 times averages are worth as preceding the shining of treatment.

Illustrate: observe from this very day certainly, require the patient to adhere to diet control for a long time.By the different labor intensity and the bodily form, roughly the staple food regulation is as follows: the overproof body weight person that has a rest, and every day, staple food was controlled at 250-300g; The labor in general person, every day 300-350g; The heavy worker, every day 400-450g.Institute's calorific requirement takes the circumstances into consideration to be replenished by non-staple foodstuff beyond the staple food.

Efficacy determination:

1, produce effects (clinical cure): the treatment symptom disappears substantially, fasting glucose＜7.2mmol/l (130mg/dl), 2 hours after the meal blood glucose＜8.3mmol/l (150mg/dl), twenty-four-hour urine sugar quantitatively＜10.0g, twenty-four-hour urine sugar quantitatively descend more than 30% before the treatment.

2, effective: treatment back symptom is obviously improved, fasting glucose＜8.3mmol/l (130mg/dl), 2 hours after the meal blood glucose＜10.0mmol/l (180mg/dl), twenty-four-hour urine sugar quantitatively＜25.0g; Or blood glucose, twenty-four-hour urine sugar quantitatively descends more than 10% before the treatment.

3, invalid: treatment back symptom does not have obvious improvement, and blood glucose, glucose in urine descend and do not reach above-mentioned standard.

Before the treatment of A group

Number numerical value project	??0	10 people	15 people	25 people	25 people
						Glucose in urine	??-	??????+	?????++	?????+++	????++++
Blood glucose		??＞130mg/dl ??(7.2mmol/l)	?＞130mg/dl ?(7.2mmol/l)	?＞130mg/dl ?(7.2mmol/l)	?＞130mg/dl ?(7.2mmol/l)

After the treatment of A group

Number numerical value project	70 people	3 people	2 people	0 people	0 people
						Glucose in urine	????-	??????+	?????++	?????+++	????++++
Blood glucose		?＞130mg/dl ?(7.2mmol/l)	?＞130mg/dl ?(7.2mmol/l)	?＞130mg/dl ?(7.2mmol/l)	?＞130mg/dl ?(7.2mmol/l)

Before the treatment of B group

Number numerical value project	??0	??????12	?????17	?????22	??????24
						Glucose in urine	??-	??????+	?????++	?????+++	?????++++
Blood glucose		＞130mg/dl (7.2mmol/l)	＞130mg/dl (7.2mmol/l)	?＞130mg/dl ?(7.2mmol/l)	?＞130mg/dl ?(7.2mmol/l)

After the treatment of B group

Number numerical value project	15 people	19 people	22 people	16 people	3 people
						Glucose in urine	?????-	??????+	?????++	?????+++	????++++
Blood glucose	＜130mg/dl (7.2mmol/l)	?＞130mg/dl ?(7.2mmol/l)	?＞130mg/dl ?(7.2mmol/l)	?＞130mg/dl ?(7.2mmol/l)	?＞130mg/dl ?(7.2mmol/l)

Side effect:

The A group is not seen gastrointestinal tract, Liver and kidney and other untoward reaction through the said method treatment.

The B group is after clothes glyburide, and part patient occurs: 1, hypoglycemia symptom: dizzy, nervous, weak etc.2, anaphylaxis, heating, erythra etc.3, gastrointestinal reaction, feel sick, untoward reaction such as vomiting.

A, B group drug effect comparison sheet

Effect number rank	Produce effects (clinical cure)	Effectively	Invalid
				The A group	????70(93％)	????75(100％)	????0(0％)
The B group	????15(20％)	????72(76％)	????3(4％)

Result: A group clinical cure rate reaches 93.3%, effective percentage 100%.

B group clinical cure rate 20%, effective percentage 76%, invalid 4%.

Below be concrete clinical case:

1, Zhang Shengli, the man, 35 years old, fell ill 3 years, be diagnosed as diabetes through the County Hospital inspection, once obey tolbutamide, diabetes pill etc., unsatisfactory curative effect.Check fasting glucose 25.7mmol/L during prescription on individual diagnosis, glucose in urine ++ ++, heavy, drinking a lot of water, urine frequently, weight loss, through clothes medicine of the present invention 3 months, polyphagia, polyuria, polydipsia transference cure, weight increase is checked fasting glucose 5.7 mmol/L, glucose in urine is turned out cloudy.

2, Yang Wentao, the man, 54 years old, fell ill 7 years, be diagnosed as diabetes, once infused, obeyed blood sugar lowering, diamicron, diabetes pill etc., curative effect is not remarkable.Symptoms such as polydipsia, polyphagia, polyuria are obvious, check fasting glucose 23.6mmol/L, glucose in urine ++ ++, accompany uncomfortable in chest, weak.Through clothes medicine of the present invention 3 months, more than three, uncomfortable in chest, weak transference cure, inspection blood glucose 5.5mmol/L, glucose in urine is turned out cloudy.

3, Liu Yufang, the woman, 36 years old, fell ill 4 years, be diagnosed as diabetes through the County Hospital inspection, once obey glyburide, tolbutamide, diabetes pill etc., unsatisfactory curative effect.Accompany weak, nervous, dizziness etc.Check fasting glucose 17.8mmol/L, glucose in urine +++.Through clothes medicine of the present invention 3 months, symptom eliminations such as weak, nervous, dizziness, fasting glucose 5.8mmol/L, glucose in urine is turned out cloudy.

Claims (1)

1, a kind of treatment diabetes medicine, it is characterized in that it is that medicine by the following weight proportioning is made: Radix Ginseng 6-9, the Radix Astragali 15-30, the Rhizoma Atractylodis Macrocephalae 15-20, Fructus Lycii 15-20, Rhizoma Polygonati 15-30, Fructus Corni 15-20, Radix Ophiopogonis 15-30, Rhizoma Dioscoreae 24-50, Radix Rehmanniae 24-50, Radix Trichosanthis 24-60, Rhizoma Coptidis 8-12.