CN101711798A - Preparation used for lowering blood fat and lowering blood sugar - Google Patents
Preparation used for lowering blood fat and lowering blood sugar Download PDFInfo
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- CN101711798A CN101711798A CN200910260973A CN200910260973A CN101711798A CN 101711798 A CN101711798 A CN 101711798A CN 200910260973 A CN200910260973 A CN 200910260973A CN 200910260973 A CN200910260973 A CN 200910260973A CN 101711798 A CN101711798 A CN 101711798A
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Abstract
The invention relates to a preparation used for lowering blood fat and lowering blood sugar, which adopts gynostemma pentaphylla, radix puerariae, glossy privet fruit, sea buckthorn, mulberry leaf and bee glue as raw materials. The preparation is characterized by being prepared from the following raw materials proportioned by weight: 390-450g of gynostemma pentaphylla, 320-380g of radix puerariae, 310-370g of glossy privet fruit, 170-230g of sea buckthorn, 120-180g of mulberry leaf and 25-55g of bee glue. By the processes of extraction, concentration, pulverization, mixing and the like, different preparations, such as capsules, tablets and the like, are prepared by combining medicinal auxiliary materials. The invention has the advantages that the formula adopts the glossy privet fruit which has the function of nourishing the liver and the kidney, the gynostemma pentaphylla and the sea buckthorn which have the functions of supplementing qi, strengthening the spleen, eliminating phlegm and relieving the stasis of blood and the radix puerariae, the mulberry leaf and the bee glue which have the functions of reducing fever and moistening dryness to together achieve the effects of nourishing yin, tonifying the kidney, reducing fever, resolving phlegm, promoting blood circulation and relieving the stasis of blood, thereby achieving the auxiliary functions of lowering blood fat, lowering blood sugar and maintaining the metabolic balance of an organism. For middle-aged and old people, the invention is suitable for dizziness, headache, chest distress, palpitation, tiredness, hypodynamia, inappetence, limb numbness, aching and limp waist and knee and the like caused by hyperlipoidemia and diuresis, skin xeransis, thirst, nausea, anorexia and the like caused by hyperglycemia.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, be used for blood fat reducing blood glucose, improve carbohydrate metabolism.
Background technology
Hyperlipidemia, hyperglycemia are the main hazard factors that threatens human health and life.Hyperlipidemia and hyperglycemia are closely related, diabetics especially, and hyperlipidemia can increase the weight of diabetes, so diabetics also needs blood lipid regulation except that the treatment hyperglycemia.Easier apoplexy, coronary heart disease, limb necrosis, retinopathy, nephropathy, the neuropathy etc. of causing of diabetes and hyperlipidemia complications, the long term complication of these diabetes is the main causes that cause diabetics deformity or premature dead.The traditional Chinese medical science thinks, the people behind a dating, the kidney qi degradation, the kidney yang kidney yin is all empty, fire is easily recklessly acted mutually, causes excessive rising of liver-YANG, fire-transformation very then, hyperactivity of fire then restrains soil, causes dysfunction of spleen and stomach, damp and hot pent-up, catharsis is unfavorable, qi depression to blood stasis and form hyperlipidemia.Diabeticss more than half merge hyperlipidemia, and the active treatment hyperlipidemia is of great benefit to blood sugar control, complication prevention.Adjust blood glucose and can to a certain degree improve blood fat, but will reach desirable level, also need the fat regulation medicine therapeutic intervention.But so develop a kind of not only blood fat reducing but also can hypoglycemic preparation very important.
Summary of the invention
The invention provides a kind of blood fat reducing, hypoglycemic preparation of being used for, not only therapeutic effect is good, and cheap, taking convenience.
The technical solution adopted in the present invention is: it adopts Herb Gynostemmae Pentaphylli, Radix Puerariae, Fructus Ligustri Lucidi, Fructus Hippophae, Folium Mori, propolis is raw material, it is characterized in that it is the preparation of being made by the following weight proportion raw material: with Herb Gynostemmae Pentaphylli 390-450g, Radix Puerariae 320-380g, Fructus Ligustri Lucidi 310-370g, Fructus Hippophae 170-230g, Folium Mori 120-180g, propolis 25-55g be raw material through extract, concentrate, technologies such as pulverizing, mixing obtain coarse powder, make different preparations in conjunction with pharmaceutic adjuvant, as capsule, tablet etc.
A preparation suggestion of the present invention day clothes effective dose is 1.8～2.4g, divides 2 times, and one after each meal, warm water delivery service gets final product.
The invention has the beneficial effects as follows: we select the Fructus Ligustri Lucidi nourishing the liver and kidney for use, Herb Gynostemmae Pentaphylli, Fructus Hippophae replenishing QI to invigorate the spleen, the expectorant blood stasis dispelling, Radix Puerariae, Folium Mori, propolis clearing heat and moistening dryness, play the merit of enriching yin and nourishing kidney, removing heat-phlegm, blood circulation promoting and blood stasis dispelling altogether, reach auxiliary antilipemic, blood sugar lowering is kept the equilibrated effect of organism metabolism.Be applicable to symptoms such as frequent micturition that symptoms such as dizziness that middle-aged and elderly people causes because of hyperlipidemia, headache, uncomfortable in chest, cardiopalmus, lassitude and weak, inappetence, numb limbs and tense tendons, soreness of the waist and knees and hyperglycemia cause, xerosis cutis, thirsty, nauseating, anorexia.
Compound basis:
Herb Gynostemmae Pentaphylli, bitter in the mouth, cold in nature; Return lung, spleen, kidney channel.Contain compositions such as saponin constituent, flavone compound, organic acid, aminoacid and trace element, polysaccharide, its effective ingredient is a Herb Gynostemmae Pentaphylli total glycosides.Effect with the spleen invigorating of nourishing heart, QI invigorating and blood regulating, expectorant blood stasis dispelling, blood fat reducing.Be used to prevent hyperlipidemia, and had palpitation is breathed hard dizziness and headache, forgetful tinnitus, heart deficiency of spleen-QI such as limbs fatigue, stagnation of phlegm blood stasis person.The animal experiment study presentation of results, Herb Gynostemmae Pentaphylli can make the neutral fat in the serum, and total cholesterol level significantly descends, also scalable lipid metabolism, stop the deposition of lipid, reduce the growing amount of free fatty, suppress glucose and enter the synthetic neutral fat of cell in blood vessel wall.Mouse stomach Herb Gynostemmae Pentaphylli extract 100mg/kg, 200mg/kg continuous 3 days, have obvious hypoglycemic activity to the alloxan diabetes model; And can obviously improve the reduction of senile rat blood glucose tolerance.Clinical observation result shows that Herb Gynostemmae Pentaphylli has the effect of hypercholesterolemia reducing, triglyceride, blood glucose and high density lipoprotein increasing, and evident in efficacy.
Radix Puerariae, sweet in the mouth, suffering, property is flat, goes into the taste warp, inspires gastric qi up, ascending the clear and descending the turbid.Contain multiple flavones ingredient, main active is big legumin, daidzin, puerarin, puerarin-7-xyloside etc.Modern medicine study shows that the isoflavonoid puerarin in the Radix Puerariae has certain curative effect to hypertension, hyperlipidemia, hyperglycemia and cardiovascular and cerebrovascular disease.Pharmacological research shows that then Radix Puerariae total flavones through the quiet notes of anesthetized dog, can make coronary flow obviously increase, and vascular resistance descends, and myocardial oxygen consumption descends; Total flavones 1mg/kg gives the injection of anesthetized dog internal carotid artery, and cerebral vascular resistance is descended, and cerebral blood flow increases.The Radix Puerariae decoct gives rabbit oral, begins 2 hours blood glucose and rises, and descends immediately, and decline in the 3rd, 4 hour is minimum, shows that Radix Puerariae has hypoglycemic effect.
Fructus Ligustri Lucidi, sweet in the mouth and little bitterness, property are flat nontoxic.Return liver, kidney channel.Has the tonifying liver kidney yin, the effect that crow must make eye bright.Contain organic acid, glycosides, terpene, steroid class, saccharide, aminoacid and trace element etc.Experiment shows that Fructus Ligustri Lucidi can significantly reduce the content of interior serum cholesterol of rabbit body and triglyceride, and the effect that prevention is arranged and subdue atheromatous plaque and alleviate plaque thickness can reduce coronary atherosclerosis pathological changes number and alleviate its degree of congestion.
Fructus Hippophae, warm in nature, sour-puckery flavor; Go into liver, stomach, intestine and small intestine warp.Eliminating phlegm and stopping cough is arranged, relieving dyspepsia, the effect of promoting blood circulation to remove blood stasis.Main chemical compositions has vitamin, organic acid, monosaccharide, aminoacid, fatty acid, lipid, phenols, flavonoid, protein and trace element etc.Wherein Fructus Hippophae polysaccharide can reduce serum low-density LP cholesterol (LDL-C), can also reduce liver inner cholesterol (TC).T-CHOL, the triglyceride that seabuckthorn fruit flavone oral liquid can reduce hyperlipidemia patient observed in clinical experiment, improves high density lipoprotein.
Folium Mori, sweet in the mouth, hardship; Cold in nature.Return lung, Liver Channel.Dispelling wind and heat pathogens is arranged, clearing away lung-heat and moistening for dryness, suppressing liver-YANG, the effect of liver heat removing and eyesight improving.Contain compositions such as inokosterone, ecdysterone, globulariacitrin, saccharide, carotene, folic acid, 17 seed amino acids, have in the defying age, blood fat reducing, inhibition body the noxious bacteria breeding and be harmful to effect such as peroxide generation.Experimental result shows that Folium Mori can make hyperlipidemia rats serum high-density LP C, HDL-C/TC obviously increase, and cholesterol, triglyceride obviously reduce, and lipid peroxide significantly reduces.Folium Mori also have hypoglycemic activity, and its contained ecdysterone all has blood sugar reducing function to the inductive blood sugar increasing of several different methods, can promote that conversion of glucose is a glycogen, but not change intact animal's blood glucose.
Propolis, acrid in the mouth, cold in nature.Have anti-inflammation, regulate immunity, antioxidation quickens the effect of organization healing.The auxiliary treatment that is used for hyperlipemia.Propolis contains a large amount of flavonoid, aromatic acid, esters and terpene compound, and Zhang Jiayong observes the therapeutic effect of propolis to the Carnis Coturnicis japonicae hyperlipemia, found that propolis can obviously reduce serum total cholesterol and content of triglyceride.Propolis can also significantly reduce hyperlipidemia rats serum TC, TG content, and can obviously increase Serum HDL-C content.Propolis energy activating cell promotes tissue regeneration, repairs sick islet cells and the tissue that decreases, the help blood sugar lowering; Diminish inflammation, treatment is infected, prevention and treatment infection complication; Blood fat reducing, vessel softening, microcirculation improvement, diabetics are taken propolis can prevent visual deterioration and cardiovascular and cerebrovascular complication; Regain one's strength, eliminate " three-many-one-little " symptom, but adhere to taking propolis reinforced immunological function, health invigorating is improved the quality of living.
To sum up, we select the Fructus Ligustri Lucidi nourishing the liver and kidney for use, Herb Gynostemmae Pentaphylli, Fructus Hippophae replenishing QI to invigorate the spleen, the expectorant blood stasis dispelling, Radix Puerariae, Folium Mori, propolis clearing heat and moistening dryness, the merit of playing enriching yin and nourishing kidney, removing heat-phlegm, blood circulation promoting and blood stasis dispelling, blood sugar lowering altogether, reach auxiliary antilipemic, blood sugar lowering is kept the equilibrated effect of organism metabolism.
The function of this product:
1, the unique molecular group contained of blood lipid regulation can adsorb the blood rubbish that is deposited on the blood vessel wall and it be transported to the liver place decompose eliminating.Efficiently purify the blood, remove blood rubbish.Alleviating vascular smooth muscle spasm, elimination fibrosis and propagation, softening tremulous pulse recovers blood vessel elasticity.Eliminate blood dense, coagulate, thick, poly-state, microcirculation improvement.
2, the micel that contains of blood sugar lowering can efficiently adsorb electronegative endotoxin, makes insulin secretion normal; Blood sugar regulation slows down the absorption of diabetes patient to sugar, and the activation islet cell function promotes insulin secretion, regulates pH value of body, strengthens islet function, improves self blood sugar lowering ability; Promote body cell to open receptor, the glucose in the absorbing blood is directly avoided sugar surplus in the blood, reaches effective hypoglycemic effect.
The advantage of this product:
1, preferably among the mountain virgin forest of the Qinling Mountains, natural wild Herb Gynostemmae Pentaphylli tender shoots, the general glycoside bioactive substance content is 8-10 a times of artificial culture product.
2, preferred natural hippophae fruit is polluted from scarcely populated " three Norths " area of China.
3, remarkable efficacy: fat, the strengthening the spleen and stomach of losing weight, separate fatigue, calmness is arranged, hypnosis, antipsycholic action, treatment migraine.
4, the biological adjusting, active cell function, the normal operation that recovers organ, other symptoms that palliate a disease and cause.
The specific embodiment
Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.
The invention will be further described below in conjunction with embodiment:
Embodiment 1: a kind of blood fat reducing, hypoglycemic preparation of being used for, adopting Herb Gynostemmae Pentaphylli, Radix Puerariae, Fructus Ligustri Lucidi, Fructus Hippophae, Folium Mori, propolis is raw material, make 1000 of capsules by the following weight proportioning: with Herb Gynostemmae Pentaphylli 390-450g, Radix Puerariae 320-380g, Fructus Ligustri Lucidi 310-370g, Fructus Hippophae 170-230g, Folium Mori 120-180g, propolis 25-55g be raw material through extract, concentrate, technologies such as pulverizing, mixing obtain coarse powder, encapsulated every 0.35g, every day 2 times, each 3, one after each meal, warm water delivery service, 3 months is a course of treatment.
Embodiment 2: a kind of blood fat reducing, hypoglycemic preparation of being used for, adopting Herb Gynostemmae Pentaphylli, Radix Puerariae, Fructus Ligustri Lucidi, Fructus Hippophae, Folium Mori, propolis is raw material, make 1000 of capsules by the following weight proportioning: with Herb Gynostemmae Pentaphylli 400-440g, Radix Puerariae 330-370g, Fructus Ligustri Lucidi 320-360g, Fructus Hippophae 180-220g, Folium Mori 130-170g, propolis 30-50g be raw material through extract, concentrate, technologies such as pulverizing, mixing obtain coarse powder, encapsulated every 0.35g, every day 2 times, each 3, one after each meal, warm water delivery service, 3 months is a course of treatment.
Embodiment 3: a kind of blood fat reducing, hypoglycemic preparation of being used for, adopting Herb Gynostemmae Pentaphylli, Radix Puerariae, Fructus Ligustri Lucidi, Fructus Hippophae, Folium Mori, propolis is raw material, make 1000 of capsules by the following weight proportioning: with Herb Gynostemmae Pentaphylli 410-430g, Radix Puerariae 340-360g, Fructus Ligustri Lucidi 330-350g, Fructus Hippophae 190-210g, Folium Mori 140-160g, propolis 35-45g be raw material through extract, concentrate, technologies such as pulverizing, mixing obtain coarse powder, encapsulated every 0.35g, every day 2 times, each 3, one after each meal, warm water delivery service, 3 months is a course of treatment.
Human feeding trial
Use the capsule of the present invention of preparation among the embodiment 3, the effect of this product is tested.
Test-meal test 1:
The study subject standard: the crowd of simple dyslipidemia, keep usual diet, blood sampling is twice in half a year.Twice serum total cholesterol (TC) is 〉=5.2mmol/L or twice serum triglycerides (TG) 〉=1.65mmol/L.
Experimental design and grouping: adopt two kinds of control design between self and group.By above-mentioned Standard Selection 100 routine experimenters, divide into groups according to the requirement of randomized, double-blind.Be divided into test group and matched group at random by experimenter's blood lipid level, consider influence result's principal element such as age, sex, diet etc. as far as possible, carry out harmony to check, with the comparability between the assurance group.Every group of experimenter's 50 examples.Test group is taken this invention capsule 2 times for each person every day, and each 3, matched group is taken placebo, takes continuously 90 days.
The result
Before the test-meal, test group and matched group crowd's age, mental status, sleep state, diet situation do not have significant difference, and two groups of crowds' fluoroscopy of chest, electrocardiogram and Abdominal B type ultrasonography check result show no obvious abnormalities.Serum TC, TG there are no significant difference (P＞0.05) sees Table 1.
The preceding two groups of crowd's serum TCs of table 1 test-meal, TG content are relatively
After the test-meal, test group crowd's serum TC and TG content all obviously reduce, self relatively reach and more all have significant difference (P＜0.01 or P＜0.05) between the matched group group, the total effective rate of test group auxiliary antilipemic is 62.0%, relatively has utmost point significant difference (P＜0.01) with 18.0% of matched group, see Table 2-table 4, show that this sample reduces examination trencherman's serum TC, the effect of TG content.
Two groups of crowds' serum TC content relatively before and after table 2 test-meal
Two groups of crowds' serum TG content relatively before and after table 3 test-meal
Two groups of effective situations of crowd's auxiliary antilipemic after table 4 test-meal
Test group crowd's serum TC and TG content all obviously reduce as a result, self relatively reach and more all have significant difference (P＜0.01 or P＜0.05) between the matched group group, the total effective rate of test group auxiliary antilipemic is 62.0%, relatively has utmost point significant difference (P＜0.01) with 18.0% of matched group, see Table 2-table 4, show that this invention preparation has the function of auxiliary antilipemic.
Test-meal test 2:
The study subject standard: the crowd of simple pathoglycemia, keep usual diet, blood sampling is twice in half a year.The fasting glucose index all 〉=7.0mmol/L.
Experimental design and grouping: adopt two kinds of control design between self and group.By above-mentioned Standard Selection 100 routine experimenters, divide into groups according to the requirement of randomized, double-blind.Be divided into test group and matched group at random by experimenter's fasting blood glucose level, consider influence result's principal element such as age, sex, diet etc. as far as possible, carry out harmony to check, with the comparability between the assurance group.Every group of experimenter's 50 examples.Test group is taken this invention capsule 2 times for each person every day, and each 3, matched group adopts blank, takes continuously 90 days.
Before the test-meal, two groups of fasting glucose index there was no significant differences (P＞0.05) see Table 5.
The preceding two groups of crowd's fasting glucose content of table 5 test-meal relatively
After the test-meal, test group crowd's fasting glucose obviously reduces, self relatively reach and the matched group group between more all have significant difference (P＜0.01).Details sees Table 6, table 7.
Two groups of crowd's fasting glucose content relatively before and after table 6 test-meal
Two groups of effective situations of crowd's blood sugar lowering before and after table 7 test-meal
Test group crowd's fasting glucose content obviously reduces as a result, self relatively reach and the matched group group between more all have significant difference (P＜0.01), it is 72.0% that test group is taken the hypoglycemic total effective rate of this invention preparation, relatively have utmost point significant difference (P＜0.01) with 16.0% of matched group, show that this invention preparation has the function of auxiliary hyperglycemic.
Claims (3)
1. one kind is used for blood fat reducing, hypoglycemic preparation, it adopts Herb Gynostemmae Pentaphylli, Radix Puerariae, Fructus Ligustri Lucidi, Fructus Hippophae, Folium Mori, propolis is raw material, it is characterized in that it is the preparation of being made by the following weight proportion raw material: with Herb Gynostemmae Pentaphylli 390-450g, Radix Puerariae 320-380g, Fructus Ligustri Lucidi 310-370g, Fructus Hippophae 170-230g, Folium Mori 120-180g, propolis 25-55g be raw material through extract, concentrate, technologies such as pulverizing, mixing obtain coarse powder, make different preparations in conjunction with pharmaceutic adjuvant, as capsule, tablet etc.
2. described a kind of blood fat reducing, the hypoglycemic preparation of being used for of root a tree name claim 1, it adopts Radix Polygoni Multiflori Preparata, Fructus Crataegi, Rhizoma Alismatis, Concha Ostreae, Poria, Semen Persicae, Radix Puerariae, Semen Coicis is raw material, it is characterized in that it is the preparation of being made by the following weight proportion raw material: with Herb Gynostemmae Pentaphylli 400-440g, Radix Puerariae 330-370g, Fructus Ligustri Lucidi 320-360g, Fructus Hippophae 180-220g, Folium Mori 130-170g, propolis 30-50g be raw material through extract, concentrate, technologies such as pulverizing, mixing obtain coarse powder, make different preparations in conjunction with pharmaceutic adjuvant, as capsule, tablet etc.
3. described a kind of blood fat reducing, the hypoglycemic preparation of being used for of root a tree name claim 1, it adopts Radix Polygoni Multiflori Preparata, Fructus Crataegi, Rhizoma Alismatis, Concha Ostreae, Poria, Semen Persicae, Radix Puerariae, Semen Coicis is raw material, it is characterized in that it is the preparation of being made by the following weight proportion raw material: with Herb Gynostemmae Pentaphylli 410-430g, Radix Puerariae 340-360g, Fructus Ligustri Lucidi 330-350g, Fructus Hippophae 190-210g, Folium Mori 140-160g, propolis 35-45g be raw material through extract, concentrate, technologies such as pulverizing, mixing obtain coarse powder, make different preparations in conjunction with pharmaceutic adjuvant, as capsule, tablet etc.
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| CN200910260973A CN101711798A (en) | 2009-12-18 | 2009-12-18 | Preparation used for lowering blood fat and lowering blood sugar |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103053638A (en) * | 2013-02-07 | 2013-04-24 | 杨波 | Flour for restoring pancreas islet function and eliminating insulin resistance and manufacturing method thereof |
| CN103190618A (en) * | 2013-04-03 | 2013-07-10 | 上海春芝堂生物制品有限公司 | Gynostemma pentaphyllum-propolis composite soft capsule and preparation method thereof |
| CN104173840A (en) * | 2014-09-10 | 2014-12-03 | 耿建芳 | Pharmaceutical composition for treating hyperlipemia |
| CN105919096A (en) * | 2016-05-16 | 2016-09-07 | 西藏康德生物科技有限公司 | Healthcare food composition and preparation and application thereof |
| CN107467470A (en) * | 2017-09-29 | 2017-12-15 | 武汉华士特工业生物技术开发有限公司 | A kind of compound solid beverage containing mulberry leaf, persimmon leaves and loguat leaf and preparation method thereof |
| CN109157565A (en) * | 2018-09-04 | 2019-01-08 | 安康金泰药业有限公司 | A kind of health composition and its application, preparation method, pulvis and health care product |
-
2009
- 2009-12-18 CN CN200910260973A patent/CN101711798A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103053638A (en) * | 2013-02-07 | 2013-04-24 | 杨波 | Flour for restoring pancreas islet function and eliminating insulin resistance and manufacturing method thereof |
| CN103053638B (en) * | 2013-02-07 | 2015-09-30 | 杨波 | A kind of flour and method for making thereof recovering islet function elimination insulin resistance |
| CN103190618A (en) * | 2013-04-03 | 2013-07-10 | 上海春芝堂生物制品有限公司 | Gynostemma pentaphyllum-propolis composite soft capsule and preparation method thereof |
| CN104173840A (en) * | 2014-09-10 | 2014-12-03 | 耿建芳 | Pharmaceutical composition for treating hyperlipemia |
| CN105919096A (en) * | 2016-05-16 | 2016-09-07 | 西藏康德生物科技有限公司 | Healthcare food composition and preparation and application thereof |
| CN105919096B (en) * | 2016-05-16 | 2020-05-22 | 西藏海容唐果健康产业有限公司 | Health food composition, preparation and application thereof |
| CN107467470A (en) * | 2017-09-29 | 2017-12-15 | 武汉华士特工业生物技术开发有限公司 | A kind of compound solid beverage containing mulberry leaf, persimmon leaves and loguat leaf and preparation method thereof |
| CN109157565A (en) * | 2018-09-04 | 2019-01-08 | 安康金泰药业有限公司 | A kind of health composition and its application, preparation method, pulvis and health care product |
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