CN101491338A - Nutrient food capable of improving sleep and preparation method thereof - Google Patents
Nutrient food capable of improving sleep and preparation method thereof Download PDFInfo
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Abstract
The invention relates to nutritional food with function of improving sleep and a preparation method thereof, and belongs to the field of functional foods. The nutritional food is prepared from the following medicine and food raw materials in portion by weight: 6 to 9 portions of Acanthopanax sessiliflorus, 1 to 3 portions of Sharpleaf Galangal Fruit, 1 to 3 portions of Semen coicis, 1 to 3 portions of sea backthern, 1 to 3 portions of hawkthorn, 3 to 6 portions of spine date seed, 3 to 6 portions of lily, 1 to 6 portions of Poria cocos, and 1 to 6 portions of balloon flower. Animal experiments and human body experiments prove that the nutritional food has obvious function of improving sleep, is used for people who need improving sleep, and is suitable for male and female but not suitable for youngsters and children.
Description
Technical field:
The present invention relates to a kind of nutraceutical of improving sleep function and preparation method thereof that has, belong to field of functional food.
Background technology:
Clinically, often run into like this some patients,, just become " good friend " with stabilizing in the course of time because serious insomnia has to come hypnosis by stable class.This phenomenon is very general in student, brain worker, the elderly, feels to stabilize to obey a little to have no relations more, and in fact, long-term use can form dependence, even habituation.Must take before the sleep every night, just have difficulty in going to sleep or sit up whole night without hypnotic, whole body has sense of discomfort, and physiology, mood, behavior and cognitive ability symptom complex occur, so cause dependence, habituation to stable class.This because of taking stable class medicine for a long time, the insomnia that occurs in case stop using more very, a series of syndromes such as whole body discomfort, vexed irritability, lassitude are withdrawal syndrome.Take the friend of downern for a long time, should be in drug withdrawal under the physician guidance.Unsuitable drug withdrawal suddenly should reduce dosage and number of times gradually, subtracts under the ladder sample, can prevent the generation of withdrawal syndrome so effectively.In addition, as if worrying the insomnia recurrence, also can select for use some nothing dependences, addicted preparation to come to remove fast and safely dependence producing drug.It is bad to sleep, and has had a strong impact on everybody physical and mental health, has also influenced everybody enthusiasm to working simultaneously.China's lunar physics technique is of long standing and well established, and old hundred property also are particular about cooking culture very much, and in drug therapy,, reinforcement curative effect auxiliary with food is method commonly used among the people.People are to better effects if, and there is wilderness demand in the nutraceutical of the improvement of instant sleep.
Summary of the invention
The present invention is directed to the defective in the above-mentioned field, provide a kind of more efficiently, have a nutraceutical that improves sleep function, its composition all is the medicine and food raw materials that nutraceutical is produced that can be used for through state food and Drug Administration's approval, the theory standard that meets integration of drinking and medicinal herbs fully is a kind of green nourishing food.
Another object of the present invention has provided the preparation method of this nutraceutical.
A kind of have a nutraceutical that improves sleep function, and it is mainly made by following medicine and food raw materials in portion by weight: Sessileflower Acanthopanax Bark tea 6-9 part, fructus alpiniae oxyphyllae 1-3 part, coix seed 1-3 part, sea-buckthorn 1-3 part, hawthorn 1-3 part, spina date seed 3-6 part, lily 3-6 part, Poria cocos 1-6 part, balloonflower root 1-6 part.
Described nutraceutical, the weight portion of its medicine and food raw materials is preferably: 6 parts of Sessileflower Acanthopanax Bark tea, 1 part of fructus alpiniae oxyphyllae, 1 part of coix seed, 1 part of sea-buckthorn, 1 part of hawthorn, 6 parts of spina date seeds, 3 parts of lilies, 1 part in Poria cocos, 1 part of balloonflower root.
The preparation method of described nutraceutical, it comprises the following steps:
(1) takes by weighing Sessileflower Acanthopanax Bark tea medicine and food raw materials in proportion, extraction process below adopting, extract: soaked 1.5 hours with 20 times of water gagings, heating is extracted 2 times, each one hour, filter merging filtrate, extract standing over night, suction filtration, filtrate suitably concentrate, concentrate is with an amount of ethyl acetate extraction 4 times, combining extraction liquid, recovery ethyl acetate, get dry extract 1 with the thick paste vacuum drying;
(2) take by weighing spina date seed, fructus alpiniae oxyphyllae, coix seed, sea-buckthorn medicine and food raw materials in proportion, use 85% alcohol extract, refluxed 3 hours, extract 3 times, merge the extract vacuum concentrate dry extract 2;
(3), carry out refluxing 60 ℃ of temperature in 50 minutes with Poria cocos, balloonflower root medicine and food raw materials 95% alcohol extract of described weight proportion.Extract reclaimed and concentrates according to the method for concentration of (1), 45-50 ℃ dry down, dry extract 3;
(4) with described weight proportion hawthorn, lily medicine and food raw materials 60% alcohol extract, carry out refluxing in 3 hours, extract is reclaimed and concentrates according to the method for concentration of (1), and 45-50 ℃ dry down, dry extract 4;
Merge dry extract 1,2,3,4 and it is ground into 200 order powder, be active component of the present invention.After the blending, be filled into capsule shells in proportion by the soft capsule method for production.
The dry extract that obtains after described the concentrating also need is following dry 3 hours at 50-60 ℃.
Described nutraceutical, its formulation are soft capsule.Every soft capsule contains active component 560mg.
Used Sessileflower Acanthopanax Bark tea medicine and food raw materials in this prescription is to cultivate with the patented technology that we have declared, and the stamen leaf of Sessileflower Acanthopanax Bark tea tree is special.
The inventor is through research repeatedly, and the checking repeatedly by animal and clinical testing, has found the nutraceutical that has having of better effect to improve sleep function finally.Disclosed by the invention have a nutraceutical that improves sleep function, and it mainly is by medicine and food raw materials Sessileflower Acanthopanax Bark tea, fructus alpiniae oxyphyllae, coix seed, sea-buckthorn, hawthorn, spina date seed, lily, Poria cocos, balloonflower root.Deng being prepared from according to a certain weight ratio.
The modern Chinese medicine theory is thought: though the insomnia cause of disease is many, due to internal cause and external cause situation: 1, ponder over overstrain too, injure the grieved then cloudy blood of heart spleen and secretly consume, have ants in one's pants; Spleen hinders that then food is few indigestion and loss of appetite, biochemical weary source, and ying blood is lost and is considered, and can not nourish the mind and causes and be insomnia; 2, have a guilty consicence, have no peace of mind and have a guilty consicence, being terrified suddenly, state of mind uneasiness, so that lie awake all night or sleep but not soundly; 3, eating and drinking without temperance, the disorder of stomach-energy eating and drinking without temperance, taste are impaired, place food is stagnated, and makes and gives birth to phlegm heat, stop up hold back in, disturb on the phlegm heat, stomach Qi is become estranged, yang-energy floating more in outside restless sleep then; 4, YANG failing to relate with YIN, breakdown of the normal physiological coordination between the heart and the kidney prolonged illness or plain body are thin and weak, kidney yin consumption is hindered, can not on give in the heart, water-fire imbalance, then heart-yang is solely high, breakdown of the normal physiological coordination between the heart and the kidney; Or the deficiency of liver-yin and kidney-yin, liver-yang is high partially, and fire is contained refreshing moving, failure of the heart and kindey to integrate and mind is not peaceful; 5, fire excess from yin deficiency, liver-yang disturbance feelings will is unsuccessful, and liver is lost bar and reaches, qi depression transforming into fire, and characteristic of fire being flaring up, the pathogenic fire disturbance mind, refreshing unpeaceful so that be insomnia.
The pathomechanism of insomnia relates to a plurality of internal organs, but the main diseases position is at the heart, heart master god, and the mind is lost and is supported or confused and worried then insomnia.Its morbidity and liver depression, timid, deficiency of spleen and stomach, stomach Qi rising closely related.Its pathological change, men outnumbered women for total genus, and negative and positive are become estranged.Because of the source of blood, be the life of essence of water and grain instituteization, on give in the heart, then gains in depth of comprehension are supported; Be hidden in liver, then the liver body is soft; Have under one's command in spleen, then biochemistry does not stop; Adjusting degree of having is changed and is smart; Be built in kidney, give on the kidney essense, meet at kidney under the motive, then the mind peacefulness in the heart.If it is all dirty that violent rage, overanxious, melancholy, overstrain etc. injure, the essence and blood in-fighting, influence each other, then one-tenth is insomnia.
Guidance according to theory of traditional Chinese medical science, we are in years of researches, by senior old docter of TCM and the scholar of conducting interviews, hospital's ancient books is investigated and consulted to the folk tradition prescription in addition, in conjunction with our research work, just develop this nutraceutical that can effectively treat the insomnia that above-mentioned reason causes, Sessileflower Acanthopanax Bark tea and spina date seed have mainly been used because of this nutraceutical again, the efficacy of a drug by force but be not hypnotic, so require take daytime, could embody the excited earlier back inhibition that the present invention will reach, alleviate tired, nourish cloudy blood, antitoxic heart-soothing and sedative makes it to breathe and is steadily that to act on hypnosis slowly sleeping, does not have dizziness next day, sleepy phenomenon, and mental status is good, and this kind effect traditional Chinese medical science claims to calm the nerves.Therefore, help every work and activity.
The present invention is that a kind of effective improvement is excessive because of mental fatigue, soreness of waist and knee joint, and cloudy anemia is few, palpitation and severe palpitation, the dysphoria deficiency of Yin deficiency of yang such as be insomnia, the medicine-food two-purpose nutraceutical of the insomnia that the sympotoms caused by cold factors heat symptom-complex causes.Therefore, according to monarch, the minister of traditional Chinese medical science prescription medicine, help, make the theory of principle, we have selected invigorating qi for tranquilization medicine-food two-purpose food in the present invention for use--and Sessileflower Acanthopanax Bark tea is as monarch, Sessileflower Acanthopanax Bark tea, strengthening by means of tonics is adjusted blood pressure, nerve, is tonified the kidney to relieve mental strain; In order to carry out qi-blood tonifying to the men and women and to adjust and alleviation fatigue, make the inferior health physical recovery to the normal health state; Again so that antitoxic heart-soothing and sedative medicine-food two-purpose food--spina date seed, fructus alpiniae oxyphyllae, coix seed etc. are minister, the symptom that removal palpitation and severe palpitation, dysphoria are insomnia, assistant is with medicine-food two-purpose food--and lily, sea-buckthorn, hawthorn " five viscera settling, and will; make us happy carefree " make it to increase hypnotic effect; Eat dual-purpose food in order to the water medicine for promoting the dispersing of the lung again--Poria cocos, balloonflower root are for making the gentle property of medicine.Make take the back gentle no dry, sleep soundly the back next day spirit and QI cleaning.More than amount to nine kinds of medicine-food two-purpose food--form prescription of the present invention.These medicine-food two-purpose food--complement each other in prescription of the present invention, effect is comprehensive, so indication is comparatively extensive.Prove that through in the past few years voluntary user's examination clothes and the animal experiment that we did the present invention's product truly has tangible curative effect.And raw material is the complete medicine-food two-purpose food of " green ", is the neoteric nutraceutical that effectively there is no any bad reaction therefore.
This nutraceutical that can effectively improve sleep disclosed by the invention, it mainly is by medicine-food two-purpose food such as Sessileflower Acanthopanax Bark tea, fructus alpiniae oxyphyllae, coix seed, sea-buckthorn, hawthorn, spina date seed, lily, Poria cocos, balloonflower roots, is prepared from above-mentioned preparation method according to a certain weight ratio.Its compound basis is as follows:
Sessileflower Acanthopanax Bark tea is medicine-food two-purpose food, the effect of tonifying the kidney to relieve mental strain.The Sessileflower Acanthopanax Bark plant is seen " Chinese Plants will " the 54 volume for details, the 115th page.The tea that the core leaf of Araliaceae Sessileflower Acanthopanax Bark is made.Press the frying of tealeaves method for production spring.Replenish qi to invigorate the spleen, tonify the kidney to relieve mental strain.Be used for the insufficiency of both the spleen and the kindey, body void is weak, poor appetite, soreness of waist and knee joint, insomnia and dreamful sleep.The pharmacological action of Sessileflower Acanthopanax Bark tea is multifarious, has strengthening by means of tonics, adjusts effects such as blood pressure, nerve, blood sugar and cholesterol.Utilize the alleviating physical fatigue function of Sessileflower Acanthopanax Bark, the total glycosides of Sessileflower Acanthopanax Bark is strengthening the human body exercise tolerance, and resisting fatigue produces and aspect such as accelerate elimination of fatigue has remarkable effect, and we use it to alleviate the tired main mechanism of improving sleep thereby Here it is.Ingredient is with wilsonii and be higher than wilsonii in the Sessileflower Acanthopanax Bark, mainly contain eleutheroside A (eleutheroside eleutheroside B (Syringin syringin), eleutheroside B1 (6,8-escoparone-7-glucoside), eleutheroside L (galactite glycosides), eleutheroside D and E (be two kinds not the purple fourth of isomorphism type get the glucoside of Syringaresinol) etc.In addition, still contain polysaccharide and 1-sesamin (1-sesamin).The alleviating physical fatigue function of Sessileflower Acanthopanax Bark we in the total glycosides antifatigue effect of experimental study Sessileflower Acanthopanax Bark mechanism.With the swimming time of doing one's utmost is index determining mouse movement endurance; Utilize lactic dehydrogenase (LDH) vigor and blood lactic acid (LAC), blood urea nitrogen (BUN), muscle glycogen and hepatic glycogen kit to detect above-mentioned every biochemical indicator, observe the antifatigue effect and the mechanism of action thereof of the total glycosides various dose of Sessileflower Acanthopanax Bark.The result shows that each dosage group of the total glycosides of Sessileflower Acanthopanax Bark is the energy significant prolongation mouse swimming with a load attached to the body time (P＜0.05 or P＜0.01) all, improves mouse movement endurance; Significantly improve the storage level (P＜0.05 or P＜0.01) of interior muscle glycogen of swimming back mice serum LDH vigor and mouse body and hepatic glycogen, significantly reduce the content (P＜0.05 or P＜0.01) of mouse whole blood LAC and serum BUN.So the total glycosides of Sessileflower Acanthopanax Bark is strengthening the human body exercise tolerance, resisting fatigue produces and aspect such as accelerate elimination of fatigue has remarkable effect, and it eliminates the tired main mechanism of improving sleep thereby Here it is.
Spina date seed is a medicine-food two-purpose food, and spina date seed also belongs to the antitoxic heart-soothing and sedative medicine.Spina date seed is the seed of Rhamnaceae plant wild jujube Zizipgus jujube Mill., also name jujube kernel (" medicine justice "), jujube nucleus (" Jiangsu flora ").It is sweet to distinguish the flavor of, and property is flat.The thoughts of returning home, spleen, liver, gallbladder channel.Function: nourishing the liver, the peaceful heart, calm the nerves, arrest sweating.Cure mainly: restlessness of asrhenia type and insomnia, palpitation with fear palpitation, abnormal sweating.Spina date seed contains triterpene compound betulic acid (betulic acid), betulin (betulin).Also contain jujuboside (jujuboside), aglycon is Jujubogenin (jujubogenin), and hydrolysis obtains ebelin lactone (ebelin lactone).From spina date seed, obtain daucosterol (daucosterd), swertisin (swertisin).Also contain volume fat oil, protein and a large amount of cGMP sample active materials in the spina date seed, and extract cAMP.Also contain forulic acid (ferulic acid), phytosterol (phytosterd) and a large amount of vitamin Cs.Many list of references reports conform to this research: the sedative-hypnotic effect that spina date seed is given birth to product and stir-fry product and general flavone and total saponin(e is compared in Wu Yulan research.Adopt mouse activity notation and collaborative sub-threshold dose yellow Jackets tranquilizing soporific method.The result shows that spina date seed is given birth to product and fried product with 10g/kg dosage gastric infusion with 20g/kg dosage and spina date seed, can significantly reduce the spontaneous activity in mice number of times; The living product of spina date seed and the product of stir-fry all can be worked in coordination with the sub-threshold dose yellow Jackets with 10g/kg and 20g/kg dosage gastric infusion significantly increases sleeping mouse number.Total saponin(e can significantly reduce the spontaneous activity in mice number of times with 240mg/kg and 480mg/kg dosed administration; Can significantly increase sub-threshold dose penta crust than righting reflex loss number of mice due to sodium is arranged with the 480mg/kg dosed administration; General flavone with 300mg/kg dosage through medicine can significantly reduce mouse from the spontaneous activity number of times, increase righting reflex loss number of mice due to the sub-threshold dose yellow Jackets.Li Yanli has inquired into the similarities and differences of life, Semen Ziziphi Spinosae (parched) syngignoscism.Adopt the sleep experiments method of the pentobarbital sodium in mice of threshold dose, observe give birth to, the Semen Ziziphi Spinosae (parched) water decoction is to the influence of mouse sleep time; The result shows, give birth to, the Semen Ziziphi Spinosae (parched) decoction all can prolong the length of one's sleep of the yellow Jackets induced mice of threshold dose, but the two syngignoscism onset time differ, it is fast than stir-baked SEMEN ZIZIPHI SPINOSAE onset time to give birth to jujube kernel.
Fructus alpiniae oxyphyllae is a medicine-food two-purpose food, and the former plant of intelligence development is zingiberaceous plant intelligence development Alpinia oxyphyllaMiq..Another name: intelligence development, fructus alpiniae oxyphyllae.Intelligence development is used as medicine with dry mature fruit.Be China's Hainan Province's endemic plant, mainly be distributed in south, Hainan Province, the southeast and middle part one band, mostly be cultivation.The area of new introducing and planting has provinces and regions such as Guangdong, Guangxi, Xishuangbanna, Yunnan, Fujian more thermally to distinguish, and the newly developed area area is little, and output is lower.The intelligence development flavor is hot, warm in nature; Return spleen, stomach warp; Has warming spleen and stopping diarrha saliva, the warm kidney controlling nocturnal emission with astringent drugs urine function that contracts of taking the photograph; Be used for the treatment of diseases such as coldness and pain in the epigastrium, the few vomiting and diarrhoea of food, hypersialosis, the enuresis, frequent urination at night, seminal emission.Source: be the fruit of zingiberaceous plant intelligence development.Theory of traditional Chinese medical science and application: this taste is hot, and is warm in nature, can go into spleen, kidney channel.There is warm spleen to take the photograph the contract effect of urine of saliva, kidney tonifying.Cure mainly the belly crymodynia, have loose bowels, disease such as many salivas, seminal emission, turbid urine, the enuresis, frequent micturition.Fructus alpiniae oxyphyllae contains alcohol, alkene, ketone and ter penoids.Has cardiac stimulant, anticancer effect.The modern study exploitation intelligence development beginning is stated from supplement to the Herbal.Modern study shows that intelligence development mainly contains volatile oil, about 1.5%.Wherein 55% is eucalyptus oil, and other parts are sequiterpenes such as zingiberene, zingiberol, still contain yakuchinone A, B, intelligence development alcohol etc.Yakuchinone A has the effect that strengthens myocardial contractive power; Intelligence development water extract and chloroform extract have syngignoscism, analgesic activity; The effect of necessarily taking the photograph has admittedly been observed in intelligence development clinically, the effect of promotion property function.Intelligence development still can improve myocardial hypoxia tolerance, promotes immunologic function, promotes hematopoiesis function, increased platelets counts and leucocyte.Intelligence development has the diastole effect to vascular smooth muscle and uterine smooth muscle in addition.In vitro test still shows inhibition rate of tumor cell is reached 70%～90%.Intelligence development is owing to narrow distribution range, and cultivation and output are all limited, can not satisfy the medication needs, still classifies one of medicine in short supply that needs development as.The production of suitable zone and the suitable regional development intelligence development of searching improves output in Hainan Province, is still an important job.
Coix seed is a medicine-food two-purpose food, main component contains amino acid (leucine, lysine, arginine, tyrosine etc.) Coixol (coixol), coix seed polysaccharide, Coixenolide (coixenolide), triterpenoid, and protein, fat, carbohydrate, Cobastab
1Kind benevolence for grass Job's tears Coix lachryma-jobiL..Also the name seed of Job's tears (" medicine justice "), Mi Ren (" book on Chinese herbal medicine is high former "), heart of a lotus seed benevolence (" book on Chinese herbal medicine is newly organized "), the seed of jog's tears (" facing the card guide "), the seed of jog's tears (" it is former that book on Chinese herbal medicine is asked "), jobstears (" the northeast medicine is planted will ") etc.It is sweet, light, cool in nature to distinguish the flavor of.Return spleen, lung, kidney channel.Function: invigorating the spleen, tonifying lung, heat-clearing, dampness removing.Cure mainly: have loose bowels, arthritis with fixed pain caused by dampness, the contraction of muscle arteries and veins, joint stuffiness, oedema, beriberi, consumptive lung disease, lung carbuncle, acute appendicitis, stranguria with turbid discharge, leukorrhea.The modern study exploitation coix seed beginning is stated from Shennong's Herbal, always medicine-food two-purpose.Modern study shows that coix seed mainly contains protein, carbohydrate, amino acid, Coixol, Coixenolide etc.Pharmacological research finds, the coix seed oil that leaches with benzinum is to striated muscle and the motor nerve ending of the frog, and low concentration is excitation, and high concentration is the paralysis effect.Coix seed oil is to breathing, and is excited in a small amount, a large amount of paralysis (central); The lung blood vessel is significantly expanded.Coixol also has inhibitory action to striated muscle.One of coix seed not only can be used to treat lung carbuncle, acute appendicitis, stranguria with turbid discharge, is with inferior disease, or beautifying drug.Industrial, also can be used to the food that extracts starch and make various reinforcings spleen to promote digestion.
Sea-buckthorn is a medicine-food two-purpose food, and sea-buckthorn (Hippophae rhamnoides L.ssp.sinensisRousi) has another name called arrow-leaved oleaster, sour willow fruit, is the conventional Chinese medicine material of the Mongols and Tibetan, has higher medical value.In " the brilliant pearl book on Chinese herbal medicine " of the Four-Volume Medical Code of the Tang Dynasty " month king medicine examine ", Tibetan medicine's medical science and the Qing Dynasty, all put down in writing the medical usage of sea-buckthorn.1977, health ministry was formally listed sea-buckthorn in the Pharmacopoeia of the People's Republic of China and is announced that in succession sea-buckthorn is a medicine food dual purpose plant.According to motherland's theory of medicine, pharmacological effects such as sea-buckthorn has sharp lung, rises sun, invigorating the spleen, nourishing the stomach, promoting blood circulation and removing blood stasis, dephlogistication and promoting nuscle growth.Be rich in multivitamin in the main component sea-buckthorn, as vitamin C, Cobastab
1, Cobastab
2, vitamin E, carrotene.Fructus hippophae and leaf all contain multiple flavone compound.According to surveying and determination, topmost flavone compound is Quercetin, Isorhamnetin, Isorhamnetin-3-β-D-glucoside, Isorhamnetin-3-β-D-rutinoside, Kaempferol and glycoside, rutin etc. in the sea-buckthorn.The flavone compound of having been identified in addition also has kind surplus myricetin, pigweed glycosides, gallic acid, catechuic acid, oleanolic acid, sitosterol, stigmasterol, digitonin, the astragalin etc. 30.Free fatty in the sea-buckthorn consists of palmitoleic acid, myristic acid, linoleic acid, oleic acid, leukotrienes.In the sea-buckthorn seed oil aliphatic acid, unrighted acid accounts for 90%, and is rich in multiple bioactivators such as unsaturated aldehydes, botany bar gum alcohols and sterol.The protein content of fructus hippophae is quite abundant.Contain 13 seed amino acids in the hippophae rhamnoides seed, contain 18 seed amino acids in pulp and the fruit juice, the amino acid that can not synthesize comprising 8 kinds of human bodies.Contain organic acid and multiple phenols such as malic acid, citric acid, tartaric acid, oxalic acid and butanedioic acid in the sea buckthorn fruit, as malol, cumarin, phenolic acid etc.Also contain trace elements such as potassium, sodium, calcium, magnesium, iron, zinc, selenium, copper, manganese in the sea-buckthorn, match with human body requirements.Other also contains carbohydrate, volatile oil and anti-cancer active matter serotonin etc.Contain a large amount of superoxide dismutase etc. in the wild sea-buckthorn.
Hawthorn is a medicine-food two-purpose food, is the fruit of rosaceous plant hawthorn Crataegus pinnatifida Bge. or fructus crataegi cuneatae.Also haw (" 101 choosing side ") in the famous mountain.Flavor acid, sweet, slightly warm in nature.Return spleen, stomach, Liver Channel.Function: long-pending, diffusing extravasated blood, expelling tenia help digestion.Cure mainly: meat Ji, Disorder lump in the abdomen, phlegm and retained fluid, ruffian are full, acid regurgitation, rush down dysentery, intestines wind, pain in the back, hernia, generation postpartum abdominal pain, lochiorrhagia, children's's breast food and stagnate.Main component is organic acid and flavone compound.Organic acid mainly contains crataegolic acid, citric acid, chlorogenic acid, ursolic acid, malic acid, oxalic acid, oleanolic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, leukotrienes, butanedioic acid, fumaric acid etc.Flavonoids mainly contains Quercetin, Vitex negundo var cannabifolia element, different Vitex negundo var cannabifolia element, cratenacin and takes off acetyl cratenacin, cosmosiin, glucose cyanidenon, Kaempferol and derivative thereof, wuzishan short, bristly hair or beard glycosides, pelargonidin, Hyperoside, epicatechin, rutin etc.In addition, still contain lactone, glycoside, lipase, protein, carbohydrate, starch, vitamin C, tannin and trace copper, sodium, zinc, iron, phosphorus, calcium etc.Anti-oxidation function, select for use the Wistar male rat as research object, when using high lipid food to feed, irritate stomach with the hawthorn and the hawthorne leaf P.E of 3 kinds of various dose, measure superoxide dismutase (SOD) and MDA (MDA) in the liver tissues of rats after 5 weeks.Find that hawthorn and leaves of Hawthorn can improve SOD activities of liver, and partly reduce MDA content in the hepatic tissue (P＜0.05), wherein MDA content is higher than high fat control group (P＜0.05) in the high dose leaves of Hawthorn intervention group liver tissues of rats; Hawthorn is better than leaves of Hawthorn in effect aspect the increase SOD vigor.The result shows that hawthorn and leaves of Hawthorn have antioxidation.The alleviating physical fatigue function is observed by rat being taken swim behind the haw thorn leaf total flavone to the time that power exhausts.Find that experimental group rats'swimming to the time that power exhausts is 272.55 ± 146.42min; The physiological saline control group is 167.1 ± 63.33min, P＜0.05.The result shows, but there is the alleviating physical fatigue function time that the haw thorn leaf total flavone significant prolongation rats'swimming power of moving to is had a rest.
Lily is a medicine-food two-purpose food, and this product is the dry meat scale leaf of liliaceous plant tiger lily Lilium lancifolium Thumb., lily Lilium brownieF.E.Brown var.viridulum Bader or Lilium tenuifolium Lilium pumilumDC..Also the name Bai Baihe (" Japan hanako materia medica ").Sweet, little hardship of distinguishing the flavor of, property is flat.Go into the heart, lung channel.Function: moisten the lung and relieve the cough, clearing away the heart fire and tranquillizing.Cure mainly: tuberculosis loudspeaker of a specified duration, cough after saliva phlegm blood, the pyreticosis that waste heat is clear, dysphoria palpitation with fear, wandering, beriberi edema.Lily bulb contains multiple alkaloids such as colchicin and starch, protein, fat etc.The flower pesticide of Lilium longiflorum contains multiple carotenoid, and wherein major part is along the antheraxanthin ester.It is best in quality to originate in Xuancheng, Anhui one band person, is the road local specialties.The Shennong's Herbal record " main perverse trend abdominal distension, pained.Sharp stool and urine, tonifying middle-Jiao and Qi.
Poria cocos is a medicine-food two-purpose food, the inducing diuresis for removing edema stranguria-relieving medicinal.Dry sclerotia for Polyporaceae plant Poria cocos Poriacocos (Schw.) Wolf.It is sweet, light to distinguish the flavor of, and property is flat.The thoughts of returning home, spleen, lung channel.Function: eliminating dampness and diuresis, beneficial spleen and stomach, antitoxic heart-soothing and sedative.Cure mainly: difficult urination, oedema turgor, phlegm and retained fluid are coughed contrary, n and V, are had loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.Main component contains B-pachyman (B-pachyman), account for 93% of dry weight, triterpene compound pachymic acid (pachymic acid), soil are herded acid (tumulosic acid), triterpene carboxylic acid (triterpene carboxylicacid), eburicoic acid (eburioic acid), loose Siberian cocklebur acid (pinicolicacid) etc.Also fatty acids is as sad (caprylicacid), undecanoic acid (undecanoic acid), laurate (lauric acid), dodecoic acid (dodecenoic acid) and palmitic acid (palmitic acid).In addition, still contain ergosterol (ergosterol), natural gum, chitin, protein, fat, sterol, lecithin, D-glucose, adenine (adenine), histidine (histidine), choline (choline), B-pachyman catabolic enzyme, lipase, protease etc.
Balloonflower root is medicine-food two-purpose food, and balloonflower root is a surname's lung pectoral.Bitter, suffering, property is flat.Attach to the lung and stomach meridians.Root for Campanulaceae Platycodon grandiflouorum Platycodongrandiflorum (Jacq.) A.DC..Function: open a surname's lung qi, eliminate the phlegm, relieve sore throat, apocenosis.Cure mainly: exogenous cough, abscess of throat, lung carbuncle pyemesis, fullness in the chest and hypochondriac pain, dysentery stomachache.Main component contains platycodin (platycodin).It is the mixture of triterpenic acid that hydrolysis produces sapogenin, and wherein a kind of is polygalic acid (polygalacic acid), and another kind is platycodigenin (platycodigenin).Still contain platycogenic acid A, B and C (platycogenic acid A, B, C), synanthrin, platycodonin, glucose and phytosterol are as the spinasterol (hitodesterol-β-D glucoside of α-spinasterol) (α-spinasteryl-β-D-glucoside) etc.
The used medicine of the present invention adopts methods such as the alcohol extract, aqueous solution soaking extraction, distilled water extraction of different purity respectively, the temperature that refluxes all is lower than 100 ℃, make active ingredient in the medicine be difficult for Yin Gaowen and change, when concentrated, adopt vacuum to concentrate simultaneously, make the active ingredient in the extract not be subjected to temperatures involved, avoided some destruction and loss, preserved the nutritional labeling and the fragrance of raw material better heat-labile active ingredient.The dry extract that obtains after concentrating need 50-60 ℃ dry 3 hours down, could finish-drying.
The traditional Chinese medical science has a well-known saying: " Diet cures more than the doctors " if the sleep-disorder of moderate is only arranged, dietetic regulation is undoubtedly safest method so.Properly utilization have calm the nerves, the Chinese medicine nutraceutical of calm effect and to daily life food, can nature and the healthy sleepiness that eats.This nutraceutical is a monarch drug in a prescription with Sessileflower Acanthopanax Bark tea in the prescription and rhizoma Gastrodiae, and its function replenishes qi to invigorate the spleen, tonifies the kidney to relieve mental strain, is used for that the insufficiency of both the spleen and the kindey, body void are weak, poor appetite, soreness of waist and knee joint, insomnia and dreamful sleep, and its alleviating physical fatigue, heart and brain are calmed the nerves; With the nourishing the liver of the spina date seed and the fruit of Chinese magnoliavine, the peaceful heart, tonifying middle-Jiao and Qi, nourishing blood and tranquilization is ministerial drug, changes restlessness of asrhenia type and insomnia; Help the help medicinal material that is usually used in improving sleep with polygala root, lily, gekko etc. again and strengthen the suitable function of many-sided symptom of prescription, thereby be applicable to that all kinds of needs improve the sleeper, reach the purpose of improving sleep, and suitable for men women and children.
The prepared dry extract active component of the present invention can add various conventional auxiliary material required when preparing different dosage form, as disintegrant, lubricant, adhesive etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as pill, powder, tablet, capsule, oral liquid etc., the present invention adopts soft capsule dosage form, dry extract and edible corn ready-mixed oil are mixed at 1: 1.2, and add 2% beeswax of cream grain weight amount, incapsulate.Be very fast because of the rhythm of life ratio of considering the modern, the employing soft capsule preparation is easy to carry, absorption is rapid.
Fill a prescription in the appliable plant composition contained alleviating physical fatigue and improve biological organic substance such as sleep suitable crowd's parts of body such as physical labourer and brain worker, student, old man are adjusted to happy state of the present invention, at first alleviate physical fatigue and stress, tired that a variety of causes causes, then in order to improve the active ingredient of sleep, the normal condition that these suitable people's group energys are gone to sleep peacefully, institute has a function of improving sleep thereby realization the present invention fills a prescription.Many suitable crowds generally react clearheaded behind the examination clothes, sensation is light, and physical fatigue is eased, and sleep state improves, and major part has all been broken away from the hypnotic that accompanies for many years.
The specific embodiment
With experimental example the present invention is described in further detail by the following examples
Embodiment 1
Feed proportioning:
Sessileflower Acanthopanax Bark tea 6000g, fructus alpiniae oxyphyllae 1000g, coix seed 1000g, sea-buckthorn 1000g, hawthorn 1000g, spina date seed 6000g, lily 3000g, Poria cocos 1000g, balloonflower root 1000g.
Its preparation method:, be prepared according to claims and described nutrient food preparation of this specification.
Embodiment 2
Feed proportioning:
Sessileflower Acanthopanax Bark tea 12000g, fructus alpiniae oxyphyllae 2000g, coix seed 2000g, sea-buckthorn 2000g, hawthorn 2000g, spina date seed 12000g, lily 6000g, Poria cocos 2000g, balloonflower root 2000g.
Its preparation method:, be prepared according to claims and described nutrient food preparation of this specification.
Embodiment 3
Feed proportioning:
Sessileflower Acanthopanax Bark tea 18000g, fructus alpiniae oxyphyllae 3000g, coix seed 3000g, sea-buckthorn 3000g, hawthorn 3000g, spina date seed 18000g, lily 9000g, Poria cocos 3000g, balloonflower root 3000g.
Its preparation method:, be prepared according to claims and described nutrient food preparation of this specification.
This nutraceutical is raw materials used to be: the allowance of the Ministry of Public Health, national Bureau of Drugs Supervision files specify is used for the raw material of the medicine-food two-purpose of nutraceutical.
To improving the criterion of sleep function nutraceutical, show that through zoopery and human experimentation nutraceutical of the present invention has the tangible sleep function that improves according to " health food check and assessment technique standard " (2003 editions).
Concrete zoopery the results are shown in experimental example 1; The suitable crowd of product obeys the back situation and sees experimental example 2.
The zoopery situation of experimental example 1 nutraceutical of the present invention is as follows:
1. materials and methods
1.1 the nutraceutical of the present invention of instrument and reagent embodiment 4 preparations is for being tried thing, electronic balance, stopwatch, spontaneous activity counter, yellow Jackets.
1.2 animal used as test ICR kind mouse, ablactation SD rat, the cleaning level is provided by medical animal experiment center, Wuhan City, the animal quality certification number: Hubei Province doctor's examination 0608. occupancy permit number: EYS0605.
1.3 method
1.3.1 48 male and female half and half of influence (experimental result sees Table 1) mouse to spontaneous activity are divided into four groups at random.The high, medium and low dosage group of nutraceutical of the present invention gives 10.0ml/Kg, 5.0ml/Kg, this nutraceutical of 2.5ml/kg respectively, and control group gives with volume physiological saline.Continuous irrigation stomach 30d, 30min after the last administration puts into spontaneous activity counter endoadaptation 5min with mouse, writes down the means of activity of mouse in the 5min then.
Nutraceutical of the present invention sees Table 1 to the influence of spontaneous activity in mice,
This nutraceutical of table 1 is to the influence of mouse 5min spontaneous activity
With control group significant difference (P＜0.05) is arranged relatively
1.3.2 to 60 of the yellow Jackets influence of the length of one's sleep (experimental result sees Table 2) mouse, the male and female dual-purpose is divided into 4 groups at random.The high, medium and low dosage group of this nutraceutical gives 10.0ml/Kg, 5.0ml/Kg, this nutraceutical of 2.5ml/kg respectively, and control group gives with volume physiological saline.Continuous irrigation stomach 30d, 30min after the last administration, every group of mouse peritoneal injection yellow Jackets 40mg/kg.The length of one's sleep (with the righting reflex loss is time for falling asleep, is sleep time from righting reflex loss to recovery time) of record mouse.Nutraceutical of the present invention sees Table 2 to the influence of the yellow Jackets inducing mouse length of one's sleep
This nutraceutical of table 2 is to the yellow Jackets inducing mouse influence of the length of one's sleep (X ± SD)
* compared significant difference (P＜0.05) with the blank group.
1.3.3 to sleep dosage influence (experimental result sees Table 3) mice group under the yellow Jackets threshold and to the same 1.3.2 of this nutraceutical, continuous irrigation stomach 30d, 30min after the last administration, each treated animal lumbar injection yellow Jackets 30mg/kg, the influence that observation number of animals (to be index more than the righting reflex loss 1min) nutraceutical of the present invention that interior each group generation is slept to 30min behind the yellow Jackets is tested the hypnosis of yellow Jackets sub-threshold dose mouse sees Table 3
This nutraceutical of table 3 is to the influence of the sleeping incidence of yellow Jackets sub-threshold dose mouse (X ± SD)
* compared significant difference (P＜0.05) with the blank group.
The preclinical influence of sleeping sees Table 4 1.3.4 nutraceutical of the present invention is to the mouse barbital sodium
This nutraceutical of table 4 is to the mouse yellow Jackets preclinical influence (X ± SD) that sleeps
* compared significant difference (P＜0.05) with the blank group.
* has compared with the blank group than significant difference (P＜0.01).
2, the conclusion per os gives the nutraceutical 32d of the present invention of the different problems of mouse, and control group and three dosage groups all find no direct sleep phenomenon in being tried thing 60min.With the blank group relatively, this health food can prolong mouse sleep time (P＜0.05) that yellow Jackets induce in middle dosage group, shorten barbital sodium sleep incubation period (P＜0.05); Can prolong mouse sleep time (P＜0.05) that yellow Jackets induce in high dose group, improve the sleeping animal incidence (P＜0.05) of yellow Jackets sub-threshold dose mouse, shorten barbital sodium sleep incubation period (P＜0.01).
Nutraceutical of the present invention has no adverse effects to weight of mice.
According to " health food check and assessment technique standard " (2003 editions) criterion, can determine that nutraceutical zoopery result of the present invention shows to have the tangible sleeper effect that improves to nutraceutical of the present invention.
Experimental example 2
1, the present invention's contained replenishing the vital essence and the blood in the appliable plant composition of filling a prescription, antitoxic heart-soothing and sedative, balancing blood pressure, alleviate biological organic substance active components such as fatigue and tranquilizing soporific, with suitable crowds such as physical labourer and brain worker, student, old men, parts of body is adjusted to happy state.The present invention fills a prescription and has courageously used stone column genseng and Sessileflower Acanthopanax Bark tea to be monarch drug in a prescription, and to promote the effect of sleep, this is that we put down in writing according to data: calm the nerves with genseng at all times, Cure for insomnia, ancient prescription have Tianwang Buxin Dan, tranquilizing the mind ball, GUIPI WAN etc.Its monarch drug in a prescription all is a genseng, and pharmacological research shows the effect that cerebral cortex is excited and suppress of regulating.Clinical experience arrives, and the effect of genseng is that excited earlier back suppresses, and take morning, is in state in high spirits daytime, and the people is slept well, and prolong the length of one's sleep.We are at first alleviated mental fatigue and nervous, the physical fatigue that a variety of causes causes, then with other active ingredient that is beneficial to sleep, add the active ingredient that makes the property of medicine gentle, and do not make the people scorching, the normal condition that these suitable people's group energys are gone to sleep peacefully, thereby the function of the Cure for insomnia that realization the present invention prescription is had.
Many suitable crowds generally react clearheaded behind the examination clothes, sensation is light, and physical fatigue is eased, and it is normal that sleep state recovers, and major part has all been broken away from other various hypnotics that accompany for many years.
2, the suitable crowd of nutraceutical of the present invention treats situation
(1) suitable crowd's situation
The suitable crowd person of voluntary participation experiment is totally 50 examples, wherein male 25 examples, and women 25 examples, the men and women was than 1: 1.Age 30-40 year 10 examples, 41-50 year 20 examples, 51-60 year 15 examples, 5 examples more than 60 years old.Wherein professional cadre (white collar) 20 people, teacher 20 people, workman 5 people, student 5 people.
(2) experiment situation
Dosage grouping and nutraceutical of the present invention give the time experiment and establish 3 seminars of basic, normal, high dosage and 1 blank group, nutraceutical of the present invention is with adult's recommended amounts oral 1120mg/d in morning every day, by adult 60kg batheroom scale, promptly 20mg/ (kg body weight) control group adopts blank.Nutraceutical of the present invention gives time totally 4 all 30d.Take nutraceutical of the present invention after one week, suitable crowd is under quiet resting state, and average 90% the groups of people feel that needs Cure for insomnia can enter the state of sleeping soundly very soon, and sleeps generally more than 8 hours continuously.The centre person of getting up in the night to urinate accounts for 21%, after continuing to take a period of time, all enters normal condition generally speaking.
Human experimentation the results are shown in following table
This nutraceutical is to the influence of the sleeping incidence of voluntary experimenter group
The high dose group of nutraceutical of the present invention has been compared than significant difference with the blank group with middle dosage group as can be seen from the above table.
Conclusion: the overall process of taking nutraceutical Cure for insomnia disease of the present invention is an incremental process, the Chinese herbal medicine effect, and haste brings no success.After date when drinking 1, sleep is fluctuation status, continues to drink when crest.Drinking generally speaking slept after 1 period tends towards stability gradually, drinks in one month, and sleep is basic to recover normal, holds on to drink the back and just do not had the situation of dyssomnia again.Effectively: in various period of the edible nutraceutical of the present invention of crowd's warp that needs Cure for insomnia disease, sleep is stabilized in the normal range (NR).Insomnia does not generally need to stop using after eliminating.By clinical verification, nutraceutical of the present invention is effective to following various insomnia: 1, fire derived from stagnation of liver-QI type; 2, the hot domestic trouble type of phlegm; 3, phlegm stagnation in collateral type; 4, type of hyperactivity of fire caused by deficiency of YIN; 5, type of deficiency of both the heart and spleen; 6, type of failure of the heart and kidney integrating; 7, type of deficiency of heart-QI and gallbladder-QI; 8, deficiency of blood liver pattern of fever.We are by clinical verification, nutraceutical of the present invention is except having treatment, because of mental fatigue excessive, soreness of waist and knee joint, cloudy anemia is few, palpitation and severe palpitation, the dysphoria deficiency of Yin deficiency of yang such as be insomnia is beyond the effect of the insomnia that the sympotoms caused by cold factors heat symptom-complex causes, can also replenishing the vital essence and the blood, antitoxic heart-soothing and sedative, balancing blood pressure, alleviate tired, improve the body and culature, delay senility, reduce headache incidence, improve one's memory, the somebody also has the effect that increases working strength.Take the without any side effects and bad reaction of nutraceutical of the present invention for a long time.
Claims (8)
1, a kind of have a nutraceutical that improves sleep function, and it is mainly made by following medicine and food raw materials in portion by weight: Sessileflower Acanthopanax Bark tea 6-9 part, fructus alpiniae oxyphyllae 1-3 part, coix seed 1-3 part, sea-buckthorn 1-3 part, hawthorn 1-3 part, spina date seed 3-6 part, lily 3-6 part, Poria cocos 1-6 part, balloonflower root 1-6 part.
2, nutraceutical according to claim 1, preferred: the weight portion of its medicine and food raw materials is: 6 parts of Sessileflower Acanthopanax Bark tea, 1 part of fructus alpiniae oxyphyllae, 1 part of coix seed, 1 part of sea-buckthorn, 1 part of hawthorn, 6 parts of spina date seeds, 3 parts of lilies, 1 part in Poria cocos, 1 part of balloonflower root.
3, the preparation method of claim 1 or 2 described nutraceutical, it comprises the following steps:
(1) takes by weighing Sessileflower Acanthopanax Bark tea medicine and food raw materials in proportion, extraction process below adopting, extract: soaked 1.5 hours with 20 times of water gagings, heating is extracted 2 times, each one hour, filter merging filtrate, extract standing over night, suction filtration, filtrate suitably concentrate, concentrate is with an amount of ethyl acetate extraction 4 times, combining extraction liquid, recovery ethyl acetate, get dry extract 1 with the thick paste vacuum drying;
(2) take by weighing spina date seed, fructus alpiniae oxyphyllae, coix seed, sea-buckthorn medicine and food raw materials in proportion, use 85% alcohol extract, refluxed 3 hours, extract 3 times, merge the extract vacuum concentrate dry extract 2;
(3), carry out refluxing 60 ℃ of temperature in 50 minutes with Poria cocos, balloonflower root medicine and food raw materials 95% alcohol extract of described weight proportion.Extract reclaimed and concentrates according to the method for concentration of (1), 45-50 ℃ dry down, dry extract 3;
(4) with described weight proportion hawthorn, lily medicine and food raw materials 60% alcohol extract, carry out refluxing in 3 hours, extract is reclaimed and concentrates according to the method for concentration of (1), and 45-50 ℃ dry down, dry extract 4;
4, merge dry extract 1,2,3,4 and it is ground into 200 order powder, be active component of the present invention.After the blending, be filled into capsule shells in proportion by the soft capsule method for production.
5, preparation method according to claim 3, the dry extract that obtains after described the concentrating also need is following dry 3 hours at 50-60 ℃.
6, described nutraceutical, its formulation are soft capsule.
7, used Sessileflower Acanthopanax Bark tea medicine and food raw materials in this prescription is to cultivate with the patented technology that we have declared, and the stamen leaf of Sessileflower Acanthopanax Bark tea tree is special.
8, the prepared dry extract active component of the present invention can add various conventional auxiliary material required when preparing different dosage form, as disintegrant, lubricant, adhesive etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as pill, electuary, tablet, various capsule, oral liquid, beverage etc.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102871082A (en) * | 2011-07-12 | 2013-01-16 | 曹桂兰 | Acanthopanax sessiliflorus product having functions of improving sleep, lubricating bowel and promoting defecation and preparation method thereof |
| CN104997870A (en) * | 2015-06-29 | 2015-10-28 | 薛红梅 | Traditional Chinese medicinal preparation for treating liver depression forming fire type insomnia |
| CN105106352A (en) * | 2015-09-07 | 2015-12-02 | 薛红梅 | Traditional Chinese medicine preparation for treating insomnia caused by pathogenic fire derived from stagnation of liver-qi |
| CN105767858A (en) * | 2016-03-10 | 2016-07-20 | 河南亿家兴生物科技有限公司 | Functional nutritional food capable of improving sleep quality |
| CN107296126A (en) * | 2017-06-23 | 2017-10-27 | 禹州市鼎信中药科技有限公司 | A kind of jujube kernel lily alternative tea |
| CN114081171A (en) * | 2020-08-09 | 2022-02-25 | 辽宁医学诊疗科技研发中心有限公司 | Functional food composition with function of assisting in improving sleep |
-
2009
- 2009-03-16 CN CNA2009100799672A patent/CN101491338A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102871082A (en) * | 2011-07-12 | 2013-01-16 | 曹桂兰 | Acanthopanax sessiliflorus product having functions of improving sleep, lubricating bowel and promoting defecation and preparation method thereof |
| CN104997870A (en) * | 2015-06-29 | 2015-10-28 | 薛红梅 | Traditional Chinese medicinal preparation for treating liver depression forming fire type insomnia |
| CN105106352A (en) * | 2015-09-07 | 2015-12-02 | 薛红梅 | Traditional Chinese medicine preparation for treating insomnia caused by pathogenic fire derived from stagnation of liver-qi |
| CN105767858A (en) * | 2016-03-10 | 2016-07-20 | 河南亿家兴生物科技有限公司 | Functional nutritional food capable of improving sleep quality |
| CN107296126A (en) * | 2017-06-23 | 2017-10-27 | 禹州市鼎信中药科技有限公司 | A kind of jujube kernel lily alternative tea |
| CN114081171A (en) * | 2020-08-09 | 2022-02-25 | 辽宁医学诊疗科技研发中心有限公司 | Functional food composition with function of assisting in improving sleep |
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