CN100548342C - Take night in Tibetan medicine for the treatment of diabetes and preparation method thereof - Google Patents
Take night in Tibetan medicine for the treatment of diabetes and preparation method thereof Download PDFInfo
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- CN100548342C CN100548342C CNB2006100110191A CN200610011019A CN100548342C CN 100548342 C CN100548342 C CN 100548342C CN B2006100110191 A CNB2006100110191 A CN B2006100110191A CN 200610011019 A CN200610011019 A CN 200610011019A CN 100548342 C CN100548342 C CN 100548342C
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Abstract
Take night in the Tibetan medicine of treatment diabetes, it is the medicament of being made by the following raw material medicaments material, Fel Ursi, Fructus Phyllanthi, Stigma Croci, artificial Moschus, Radix Berberidis Amurensis, GANGCAO GAO, Chinese ink, Semen Cassiae, Semen Arecae.The preparation method that is used for the treatment of the diabetes night oral administration Tibet medicine takes by weighing medical material in proportion, and Fel Ursi, artificial Moschus, Stigma Croci are made as fine powder respectively, and all the other medicines are made as fine powder altogether, evenly is powder with each component by described mixed.Also can be made as ball, loose, capsule, soft capsule, electuary.The present invention meets the relevant pharmaceutical control law regulation of country, and heavy metal reaches mark, and natural medicine is additive-free, has no side effect.Effective blood sugar lowering, and the effect of remarkable reduction serum levels of triglyceride is arranged, nephropathy also there is significant curative effect.Medicine absorbs soon, curative effect is high, has the effect of curing the disease, keep healthy, keeping fit.Medicine need not decoct, dosage is little, taking convenience.
Description
Technical field
The present invention relates to a kind of Tibetan medicine and preparation method thereof method, particularly night takes in Tibetan medicine for the treatment of diabetes and preparation method thereof.
Background technology
Tibetan medicine's pharmacy with nearly bimillennial theoretical practical basis is the important component part of China's traditional medicine, and Tibetanmedicine has the ethnomedicine system of complete theory of medicine and the medical content of enriching.The upper-class monk that mostly is Tibetan Buddhist grasps.Tibetanmedicine is summarised as " dragon ", " red crust " and " cultivation " with Human Physiology, pathology.Think that " dragon " is to keep human life and functions such as limb activity, QI-blood circulation, food digestion, domination breathing and reproduction; " red crust " be regulate body temperature, be responsible for and hunger and thirst and function such as vision; " Baconic " regulates the girth of a garment, sleep, is responsible for functions such as the personality and the sense of taste.Tibetan medicine and pharmacology is having special method and curative effect aspect commonly encountered diseases, frequently-occurring disease and the multiple difficult miscellaneous diseases of treatment cardiovascular system diseases, liver and gall diseases, respiratory system.Tibetan medicine and pharmacology is to building body, and improving body immunity has special research.The advantage of Tibetan medicine is Special geography and climatic environment, messenger drug with material effectively accumulate height, component content is many, biological activity is strong, pollution-free etc.But there is the problem of heavy metals exceeding standard in the Tibetan medicine that has.
Diabetes are modal endocrinopathyes, and diabetes cannot be cured all one's life, and extensively and serious, the healthy of the mankind in serious harm to complication.Big to the side effect of medication of Diabetes Mellifus Western medicine at present, the Chinese patent medicine curative effect is low.
Summary of the invention
The objective of the invention is to send Tibetan medicine's classical works to guide, put into practice, study arrangement according to satin drill, propose a kind of evident in efficacy, have no side effect and take at night that heavy metal is up to standard in the Tibetan medicine of treatment diabetes and the preparation method of this medicine.
Technical scheme of the present invention is, takes night in the Tibetan medicine of treatment Rezulin, and it is the medicament of being made by following weight parts proportion raw material medical material,
Fel Ursi 0.01-0.05 Fructus Phyllanthi 6-10 Stigma Croci 1-5
Artificial Moschus 0.01-0.05 Radix Berberidis Amurensis 3-8 GANGCAO GAO 0.3-0.8
Chinese ink 0.008-0.015 Semen Cassiae 1-5 Semen Arecae 3-8.
Take night in the preparation method of the Tibetan medicine of treatment Rezulin, take by weighing medical material in proportion, Fel Ursi, artificial Moschus, Stigma Croci are made as fine powder respectively, all the other medicines are made as fine powder altogether, evenly are powder with each component by described mixed.Also can be made as ball, loose, capsule, soft capsule, electuary.
Can also be with various medical material pulverize separately to particle diameter 150-200 order coarse powder, it is the 250-2500 order that reuse ultrafine dust pulverizer is crushed to particle diameter.
The opinion of nature of Tibetan's traditional culture and Tibetanmedicine is pursued harmony and the unification of man and nature, think disease be human body environment and nature environment unbalance due to, the treatment disease is recovered exactly and reconstruction to be equilibrated at be that " four lines is assembled and health, and four is unbalance and send out disease, more puts treatment according to four lines performance face " arranged.Health, disease and treat all as mutual the say so internal characteristics of Tibetanmedicine of disputatious science, be with the Tibetan traditional culture in religion, philosophy, humanity and folk custom etc. closely bound up.Tibetanmedicine thinks that diabetics also has " dragon-red " combination of syndromes, " training-red " combination of syndromes, " Long-Pei " combination of syndromes based on " red crust " patient, is feature with polyphagia, polydipsia, polyuria, is mainly carbohydrate fever, profit, plays imbalance.Be that the traditional Chinese medical science is sayed surfeit delicious food savoury and got.Be that interior-heat fumigation, spleen lose fortuneization, general shape on the vital essence, cloudy Tianjin of thermal burn then causes thirsty polydipsia for a long time, polyphagia but emaciation, the frequency of urinating is many.
Tibetan medicine's theory is thought, in early morning, the function of human body level is " Baconic " foul smell ascension just, excrete best the time.At noon, the function of human body level is " a red crust ", is that the function of human body activity is the strongest the time.At night, the function of human body level is " wind ", when being the variation of function of human body adjusting foul smell deposition.Relative variation can take place with the human body regulative mechanism in " dragon ", " red crust ", " Baconic " three factors in the time of one day different.The present invention is directed to the cause of disease of diabetes, is cold in nature, dried, pure with Tibetan medicine with sweet in the mouth, bitterness.While is at the rising or the decline of morning and evening function of human body regulatory function, the recovery of function of human body regulatory function or weaken, the difference symptomatic treatment, the heat of accomplishing to disappear is amusing that removing dampness, clearing stomach expel the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, nourishing YIN to relieve dryness and blood are promoted blood circulation, to improve the human body function of exempting from service, regulate the human body body fluid balance, the human body integral functional status is improved and replenishes, to reach prevention and Comprehensive Treatment to treatment of diabetes, complication.
Each component raw material medicine that the present invention adopts is,
Fel Ursi, the gallbladder of ursidae animal black bear or brown bear.Bitter in the mouth, cold in nature; Can stop blooding, treat skin ulcer, removing the necrotic tissue and promoting granulation, dysentery relieving makes eye bright; Control wound, " red crust " disease, hepatopathy, oculopathy, dysentery has better effect to hemorrhage and wound infection.
Fructus Phyllanthi, Phyllanthus emblicaL.-Emblica officnalis L. is an euphorbia plant.Claim Phyllanthus embical fruit, Yunnan Fructus Canarii albi again, Yunnan-Guizhou two provinces common name Fructus Canarii albi.Sweet in the mouth, acid, puckery, cool in nature or flat, imitate sharp; Energy clearing away heat from blood, gallbladder-heat are good for the stomach, and help digestion, and promote the production of body fluid cough-relieving, blood pressure lowering; Control heat in blood, control " red crust " disease, " Baconic " disease, " training red " combination of syndromes, dysentery, liver-gallbladder disease, oculopathy, high mountain plethora, vitamin C deficiency, hypertension, dyspepsia, cough, laryngopathy, xerostomia, hot edema, frequent micturition.
Stigma Croci, the top and the stigma of irides Stigma Croci style.Sweet in the mouth, gas perfume (or spice), cool in nature, imitate heavy; The energy removing heat from the liver is trained first body-building, hemostasis, controls the old and new's hepatopathy, interior external haemorrhage, and health is weak.Blood circulation promoting and blood stasis dispelling, dispersing stagnation and relieving accumulation of pathogens is controlled troubled thoughts pent-up, and the chest and diaphragm spleen is vexed, spits blood, and typhoid fever is gone mad, and is frightened fear in a trance, women's amenorrhea, stasis of blood stomachache was fallen Piao and was swollen and ache puerperal.
The artificial Moschus, natural Moschus's succedaneum, effect is with natural Moschus.
Radix Berberidis Amurensis is the skin of several Berberis Berberis of Berberidaceae spp..Bitter in the mouth, cold in nature is imitated dry; Can detoxify row's yellow fluid, dampness; Control dyspepsia, diarrhoea dysentery, old heat, gonorrhea, " grasserie ", oculopathy.
Semen Arecae, Areca catechu L. is the seed of babassu Semen Arecae.Acrid in the mouth, warm in nature; Kidney invigorating and YANG supporting; Control nephropathy, take care of one's teeth.
GANGCAO GAO, root of the fabaceous Radix Glycyrrhizae of Glycyrrhiza uralensis Fisch. or root stock soft extracts.Sweet in the mouth, property is flat, and the digestion back is cool in nature.The energy eliminating phlegm and relieving cough is moisturized, and does " yellow fluid " promoting blood circulation.Control pneumonopathy, lung-heat, cough, disorders of meridian, angiopathy, scarlet fever, dried drinking controlled " yellow fluid " disease.
Semen Cassiae, the seed of the fabaceous Semen Cassiae of Cassia tor L., mildly bitter flavor, property is flat; Can holder draw yellow fluid, parasite killing, calm, nourishing; Control " yellow fluid " disease, tinea, hysteria, epilepsy, weakness.
Chinese ink is for pine soot with go into the China ink that glue juice, spice etc. are processed into.It is good being used as medicine with Chen Jiuzhe.Acrid in the mouth, property is flat.Hemostasis, detumescence is controlled haematemesis, epistaxis, metrorrhagia and metrostaxis, dysentery, carbuncle carbuncle on the back.
GANGCAO GAO can replace with Radix Glycyrrhizae among the present invention, and its ratio is 25: 1.
Of the present inventionly prove that through acute toxicity test its toxicity is smaller.Carry out ICR its mouse oral acute toxicity test: LD
50=7.8678g/kg body weight, its 95% credibility interval is 6.6419-9.3222g/kg, maximum tolerated dose MTD is the 11.00g/kg body weight; Do not see after the administration that tangible toxic reaction appears in mice.
The present invention carries out rat stomach administration long term toxicity test: carried out administration 90 days with the SD rat, drug withdrawal recovers 30 days long term toxicity test, design low dose group (the 1.5g/kg body weight is 75 times of clinical recommended drug amount), middle dosage group (the 3.00g/kg body weight is 150 times of clinical recommended drug amount), high dose group (the 6.00g/kg body weight is 300 times of clinical recommended drug amount).The result shows: the administration phase and convalescent period experimental animal generally in order, organ weights is analysed to look into organ coefficient, hematology and blood parameters, histopathology and be there is no the abnormal change relevant with medicine.
The test of pesticide effectiveness of blood sugar lowering of the present invention: oral administration of the present invention has and reduces the effect that normal mouse epinephrine hypertension meter sugar mice and alloxan cause the blood glucose in diabetic mice level; Basic, normal, high three dosage groups all can significantly be improved the effect of normal mouse glucose tolerance, have the effect that remarkable reduction alloxan causes the hyperglycemic rat blood sugar level.The present invention all has the effect of remarkable reduction serum total cholesterol at basic, normal, high three dosage; Also have the effect that significantly reduces the diabetes rat serum levels of triglyceride in high dose group, but when reducing serum total cholesterol, serum high-density LP, cholesterol levels are not had obvious influence.
Adopt traditional disintegrating process to pulverize medical material, the medical material medium particle diameter that obtains usually is the 150-200 order, and the present invention adopts superfine technique to pulverize medical material, and the medical material medium particle diameter that obtains is the 1250-2500 order.The active ingredient of traditional medical material all is to discharge by cell wall or cell membrane, the medical material that the present invention pulverizes is than under the fineness, the crude drug cell sporoderm-broken rate is no less than 95%, and the active ingredient of medical material directly exposes, and will improve the effect and the bioavailability of medical material so greatly.
The present invention can use separately also and can be used with the Tibetan medicine of taking morning in the treatment diabetes, is used better effects if with the Tibetan medicine of taking morning in the treatment diabetes.When using separately, every day each 1 time sooner or later, each amount is the 1.2-1.6 gram.With take Tibetan medicine in the treatment diabetes morning when being used, take medicine night every day 1 time, each amount restrains for 1.2-1.6.Through the clinical trial of enlightening celebrating state Tibetan medicine hospital, total diabetes, nephrotic's nearly 1000 people use medicine of the present invention, and by the tracking statistics to each case, total effective rate reaches more than 90%, stable curative effect, basic toxic effects.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
Meet the relevant pharmaceutical control law regulation of country, heavy metal reaches mark, and natural medicine is additive-free, has no side effect.Effective blood sugar lowering, and the effect of remarkable reduction serum levels of triglyceride is arranged, nephropathy also there is significant curative effect.Medicine absorbs soon, curative effect is high, has the effect of curing the disease, keep healthy, keeping fit.Medicine need not decoct, dosage is little, taking convenience.
Specific implementation method
The used medicine of check the present invention should meet the Tibetan medicine relevant criterion, and medicine is removed non-medicinal part, impurity and the deteriorated goods that go rotten.Take by weighing medical material in proportion, Fel Ursi, artificial Moschus, Stigma Croci are made as fine powder respectively, all the other medicines are made as fine powder altogether, evenly are powder with each component by described mixed.Various medical material pulverize separately are to particle diameter 150-200 order coarse powder, and it is the 250-2500 order that reuse energy property ICMJ-400 type supersonic speed low temperature four-way head-on collision equipment is crushed to particle diameter with coarse powder, puts in the clean hermetic container standby; According to the form below takes by weighing each amounts of components, evenly is powder with each component by described mixed.
| Consumption (gram) component | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| Fel Ursi | 0.01 | 0.03 | 0.02 | 0.01 | 0.05 |
| Fructus Phyllanthi | 9 | 7 | 10 | 8 | 6 |
| Stigma Croci | 5 | 3 | 3 | 3 | 1 |
| The artificial Moschus | 0.02 | 0.03 | 0.01 | 0.03 | 0.02 |
| Radix Berberidis Amurensis | 6 | 5 | 6 | 3 | 7 |
| GANGCAO GAO | 0.5 | 0.6 | 0.4 | 0.7 | 0.8 |
| Semen Cassiae | 1 | 4 | 3 | 3 | 5 |
| Chinese ink | 0.008 | 0.015 | 0.012 | 0.010 | 0.011 |
| Semen Arecae | 4 | 6 | 3 | 8 | 6 |
With each component mix homogeneously, be powder bottle or bag package encapsulation.Be made as the ball that grain weighs 0.4 gram with in powder, adding adjuvant according to a conventional method by traditional method.Powder being added adjuvant pack into and pack in the hard capsule, then is the hard capsule dosage form, is made as soft capsule by the conventional preparation technology of soft capsule.Powder is added pharmaceutically acceptable auxiliary agent, be processed into the water droplet ball with Device for producing a granulated material.Powder is added pharmaceutically acceptable auxiliary agent system electuary according to a conventional method.
Claims (8)
1, takes a kind of night in the Tibetan medicine of treatment diabetes, it is characterized in that it is the medicament of being made by following weight parts proportion raw material medical material
Fel Ursi 0.01-0.05 Fructus Phyllanthi 6-10 Stigma Croci 1-5
Artificial Moschus 0.01-0.05 Radix Berberidis Amurensis 3-8 GANGCAO GAO 0.3-0.8
Chinese ink 0.008-0.015 Semen Cassiae 1-5 Semen Arecae 3-8.
2, take night as claimed in claim 1 in the Tibetan medicine of treatment diabetes, it is characterized in that, said medicament is ball, loose, capsule or electuary.
3, take night as claimed in claim 1 in the preparation method of the Tibetan medicine of treatment diabetes, it is characterized in that, take by weighing medical material in proportion, Fel Ursi, artificial Moschus, Stigma Croci are made as fine powder respectively, all the other medicines are made as fine powder altogether, evenly are powder with each component by described mixed.
4, take night as claimed in claim 3 in the preparation method of the Tibetan medicine of treatment diabetes, it is characterized in that various medical material pulverize separately are to particle diameter 150-200 order coarse powder, it is the 250-2500 order that reuse ultrafine dust pulverizer is crushed to particle diameter.
5, wanted for 3 described nights and take to it is characterized in that as right, with powder controlling the water circulation drop pill according to a conventional method in the preparation method of the Tibetan medicine of treatment diabetes.
6, take night as claimed in claim 3 in the preparation method of Tibetan medicine of treatment diabetes, it is characterized in that, powder glue capsule according to a conventional method.
7, take night as claimed in claim 3 in the preparation method of the Tibetan medicine of treatment diabetes, it is characterized in that, powder is made soft capsule according to a conventional method.
8, take night as claimed in claim 3 in the preparation method of the Tibetan medicine of treatment diabetes, it is characterized in that, powder is made electuary according to a conventional method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CNB2006100110191A CN100548342C (en) | 2006-07-04 | 2006-07-04 | Take night in Tibetan medicine for the treatment of diabetes and preparation method thereof |
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| CNB2006100110191A CN100548342C (en) | 2006-07-04 | 2006-07-04 | Take night in Tibetan medicine for the treatment of diabetes and preparation method thereof |
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| CN100548342C true CN100548342C (en) | 2009-10-14 |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103736071B (en) * | 2014-01-23 | 2016-05-11 | 西藏金哈达药业有限公司 | A kind of composition with auxiliary hyperglycemic effect and application thereof, preparation method |
| CN105497646A (en) * | 2016-01-22 | 2016-04-20 | 久美彭措 | Tibetan medicine for treating kidney diseases of children |
| CN106620085A (en) * | 2016-10-28 | 2017-05-10 | 西藏藏医学院 | Tibetan medicine composition for treating diabetes and preparation method of Tibetan medicine composition |
| CN113440577A (en) * | 2021-08-16 | 2021-09-28 | 洛嘎 | Night oral Tibetan medicine for treating diabetes and preparation method thereof |
| CN113521229A (en) * | 2021-08-16 | 2021-10-22 | 洛嘎 | Morning-taking Tibetan medicine for treating diabetes and preparation method thereof |
| CN114796321A (en) * | 2022-05-06 | 2022-07-29 | 成都中医药大学 | Application of Tibetan medicine composition in preparing medicine for treating type 2 diabetes |
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Granted publication date: 20091014 Termination date: 20120704 |