CN104398822A - Traditional Chinese medicine for treating kidney-deficiency uterine prolapse and a preparation method - Google Patents

Traditional Chinese medicine for treating kidney-deficiency uterine prolapse and a preparation method Download PDF

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CN104398822A
CN104398822A CN201410669052.8A CN201410669052A CN104398822A CN 104398822 A CN104398822 A CN 104398822A CN 201410669052 A CN201410669052 A CN 201410669052A CN 104398822 A CN104398822 A CN 104398822A
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herba
radix
chinese medicine
fructus
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刘彩娟
李秀苇
解淑琼
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Abstract

The invention discloses a traditional Chinese medicine for treating kidney-deficiency uterine prolapse and a preparation method. The traditional Chinese medicine comprises the following raw materials: astragalus mongholicus, caulis spatholobi, cuscuta chinensis, fructus lycii, a himalayan teasel root, morinda officinalis, rehmannia glutinosa, raspberry, cowpea, broomrape, herba pyrolae, memorialis, cynomorium songaricum, orchis, nothopanax delavayi, asiatic striga herb, fructus polygoni orientalis, rhizoma cyperi, triplostegia glandulifera wall, hypoxis aurea, Chinese yam, schizophragma integrifolium, fructus corni, cuttlebone, acalypha australis, rhizoma cimicifugae, liquorice and pomegranate bark. The medicine has the benefits that the medicine has effects of tonifying qi, and tonifying a kidney for relieving desertion, mainly treats the kidney-deficiency uterine prolapse, has a good curative effect, is simple and convenient in preparation technology, small in toxic and side effect and convenient to administer, can reach a focus, and has a shorter treatment course; the kidney-deficiency uterine prolapse has low possibility of recurrence after curing; and an agent is easy to manufacture and low in cost.

Description

A kind of Chinese medicine and preparation method for the treatment of renal deficiency type uterine prolapse
Technical field
The present invention relates to pharmaceutical technology, particularly a kind of Chinese medicine and preparation method for the treatment of renal deficiency type uterine prolapse.
 
Background technology
Uterine prolapse refers to that uterus declines from normal position along vagina, and it is below horizontal that cervix uteri reaches ischial spine, even emerges in outside vaginal orifice, deviates from block thing clinically with intravaginal, and aches for its feature with bearing down and lumbosacral region.Under normal circumstances, uterus is positioned in the middle part of pelvic cavity, in leaning forward or hypsokinesis position, the uterus longitudinal axis becomes 90 ~ 100 jiaos with the vagina longitudinal axis, cervix uteri is positioned at more than ischial spine level, the entopic maintenance in uterus, main by pelvic diaphragm muscle and fascia (particularly levator ani and fascia), and the ligament (as cardinal ligament of uterus and jarjavay's ligaments) etc. being attached to uterus plays supporting function.The size of the change of uterus position and the height of intraabdominal pressure and pelvic floor tissue supporting strength is closely related.Uterine prolapse is multiple is born in fecund or puerperal, and directly relevant with childbirth.Childbirth can damage uterus supporting tissue (in pelvic cavity fascia) and levator ani, if but suitably have a rest puerperal, strengthen nutrition, especially coordinate motion exercise in puerperal, generally all recover normal, and do not occur to prolapse or have also light.If damage heavier, or in dreadful conditions of life, puerperal is engaged in physical work too early, comprises the long period to be in station, crouching position person, or under having chronic cough, diarrhoea, constipation etc. to increase abdominal pressure situation, then easily uterine prolapse occurs.
The cause of disease of uterine prolapse mainly contains :
1, parturition injury: such as production time long difficult labour, easily damage pelvic diaphragm muscle and ligament; Leave the bed too early in puerperal period and do housework or work etc. of bearing a heavy burden too early.
2, long-term abdominal pressure increases is a large factor.As chronic cough, habitual constipation, for a long time bear a heavy burden work, the motion regularly doing undue force and abdominal cavity are long has tumor etc. that abdominal pressure can be caused to increase, and impel uterus to move down.
3, menolipsis is a large inducement.It is reported, uterine prolapse occurs in menopause the latter and accounts for 2/3.Postmenopausal estrogen level is not enough, and make the genitals with hormonal dependent start atrophy, degeneration with tissue, pelvic muscle flexibility decrease, support the laxity of ligament in uterus, result makes whole pelvic floor tissue become weakness.
4, pelvic floor tissue dysplasia or degeneration, the congenital uterus of some women or Pelvic floor dysplasia, also can make uterus prolapse too early.
Uterine prolapse is divided into three degree:
I degree: cervix uteri hangs down to below ischial spine plane, but the person that is no more than vaginal orifice.
II degree: refer to that cervix uteri is deviate from outside vaginal orifice, and body of uterus or part body of uterus are still in intravaginal.But excessive because comprising scope, the lighter only cervix uteri deviates from outside vaginal orifice, and severe one can extend because of cervix uteri, thus extend cervix uteri and vaginal wall all deviate from outside vaginal orifice.II degree of uterine prolapse divides again gently, weighs amphitypy: light II degree---and cervix uteri and part anterior vaginal wall turn over outside vaginal orifice; Weigh II degree---cervix uteri and part palace body and the large portion of anterior vaginal wall or all turn over outside vaginal orifice.
III degree: refer to whole body of uterus and cervix uteri and all anterior vaginal wall and part posterior vaginal wall all turn over outside vaginal orifice.
The traditional Chinese medical science is thought that primary disease is many and is exerted oneself too because of during childbirth, or work in puerperal too early, causes overstrain impairing the spleen, collapse of QI, receives to take the photograph and have no right; Or deal with improperly because of during childbirth, trauma collaterals of the uterus, collaterals of the uterus loses system; Or delivery and feed infant is too much, chamber hindered, kidney qi virtual loss, the debility of CHONG and REN meridians; Or ferritic is weak, old prolonged illness, duty is exerted in constipation, loses caused by the astringency inducing.The deficiency of vital energy should be divided into emphatically clinically, suffer from a deficiency of the kidney and damp and hot three kinds of pattern of syndrome
1. the deficiency of vital energy.Main manifestations is that uterus moves down, or deviates from outside vaginal orifice, and labor is then aggravated, and lower abdomen drops, and god is tired weak, and deficiency of QI with disinclination to talk, frequent micturition, or profuse leukorrhea, color white matter is rare, lustreless complexion, light red tongue, thin fur, and moderate pulse is weak.
2. suffer from a deficiency of the kidney.Main manifestations is that uterus moves down, or deviates from outside vaginal orifice, and lower abdomen drops, frequent micturition, waist soreness, dizziness and tinnitus, light red tongue, thin fur, deep-thready pulse.3. damp and hot.Main manifestations is that uterus moves down, or deviates from outside vaginal orifice, and bitter taste appetite is poor, or the jaundice of body order, or heating is afraid of cold alternately, wiry and frequent pulse.
Uterine prolapse is divided into symptomatic bulging and non-symptomatic bulging clinically.Non-symptomatic bulging does not advocate operative treatment usually.
Western medical treatment uterine prolapse is divided into non-operative treatment and operative treatment.Non-operative treatment has pelvic diaphragm muscle training, pessulum, acupuncture or electromagnetism neural stimulation therapy etc.Need to be grasped medical expertise non-operative treatment is consuming time more, operation requirements is stricter more.Operative treatment cost is high.Doctor trained in Western medicine curative effect is not satisfactory, easily recurs, and extensive patients is not easy to accept Modern medical therapy scheme.
Chinese medicine has QI invigorating to promote, effect that kidney tonifying takes off admittedly, cure mainly renal deficiency type uterine prolapse good effect, and processing technology is easy, the little and convenient drug administration of toxic and side effects, focus of going directly, and the course for the treatment of is shorter, not easily recurs after healing, and medicament is easy to manufacture, new drug with low cost.
 
Summary of the invention
Technical problem to be solved by this invention is, provide one and have QI invigorating lifting, effect that kidney tonifying takes off admittedly, cures mainly the Chinese medicine of uterine prolapse.The present invention utilizes Traditional Chinese medical theory, and by regulating nerve, the immune system of animal economy, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, specific aim is stronger, convenient drug administration, safe and effective, timely symptom management, obviously reduces the generation of complication, improve cure rate, reduce relapse rate, improve the quality of life etc. of patient.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of renal deficiency type uterine prolapse, comprising following raw medicinal material: the Radix Astragali, Caulis Spatholobi, Semen Cuscutae, Fructus Lycii, Radix Dipsaci, Radix Morindae Officinalis, Radix Rehmanniae Preparata, Fructus Rubi, Semen vignae sinensis, Herba Orobanches, Herba Pyrolae, Herba Gonostegiae hirtae, Herba Cynomorii, Herba Orchidis Latifoliae, metapanax of araliaceae, Herba Strigae Asiaticae, Fructus Polygoni Orientalis, Rhizoma Cyperi, Radix Triplostegiae Grandiflorae, Herba hypoxis aureae, Rhizomadioscoreae, Radix Kadsurae Coccineae, Fructus Corni, Endoconcha Sepiae, Herba Acalyphae, Rhizoma Cimicifugae, Radix Glycyrrhizae and Pericarpium Granati.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Astragali 25-44 weight portion, Caulis Spatholobi 16-28 weight portion, Semen Cuscutae 20-33 weight portion, Fructus Lycii 23-35 weight portion, Radix Dipsaci 10-22 weight portion, Radix Morindae Officinalis 14-25 weight portion, Radix Rehmanniae Preparata 28-40 weight portion, Fructus Rubi 22-34 weight portion, Semen vignae sinensis 14-27 weight portion, Herba Orobanches 11-23 weight portion, Herba Pyrolae 10-22 weight portion, Herba Gonostegiae hirtae 13-25 weight portion, Herba Cynomorii 12-24 weight portion, Herba Orchidis Latifoliae 13-26 weight portion, metapanax of araliaceae 13-25 weight portion, Herba Strigae Asiaticae 14-25 weight portion, Fructus Polygoni Orientalis 13-28 weight portion, Rhizoma Cyperi 25-38 weight portion, Radix Triplostegiae Grandiflorae 15-30 weight portion, Herba hypoxis aureae 8-19 weight portion, Rhizomadioscoreae 19-32 weight portion, Radix Kadsurae Coccineae 8-18 weight portion, Fructus Corni 14-27 weight portion, Endoconcha Sepiae 16-31 weight portion, Herba Acalyphae 9-20 weight portion, Rhizoma Cimicifugae 12-30 weight portion, Radix Glycyrrhizae 14-30 weight portion and Pericarpium Granati 7-17 weight portion.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Astragali 27-41 weight portion, Caulis Spatholobi 18-25 weight portion, Semen Cuscutae 21-30 weight portion, Fructus Lycii 25-33 weight portion, Radix Dipsaci 12-20 weight portion, Radix Morindae Officinalis 16-22 weight portion, Radix Rehmanniae Preparata 28-37 weight portion, Fructus Rubi 22-32 weight portion, Semen vignae sinensis 15-24 weight portion, Herba Orobanches 12-21 weight portion, Herba Pyrolae 12-20 weight portion, Herba Gonostegiae hirtae 15-23 weight portion, Herba Cynomorii 14-21 weight portion, Herba Orchidis Latifoliae 15-22 weight portion, metapanax of araliaceae 14-23 weight portion, Herba Strigae Asiaticae 17-23 weight portion, Fructus Polygoni Orientalis 16-26 weight portion, Rhizoma Cyperi 27-35 weight portion, Radix Triplostegiae Grandiflorae 17-26 weight portion, Herba hypoxis aureae 9-16 weight portion, Rhizomadioscoreae 21-30 weight portion, Radix Kadsurae Coccineae 10-16 weight portion, Fructus Corni 14-24 weight portion, Endoconcha Sepiae 17-29 weight portion, Herba Acalyphae 9-16 weight portion, Rhizoma Cimicifugae 12-23 weight portion, Radix Glycyrrhizae 18-27 weight portion and Pericarpium Granati 8-15 weight portion.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: the Radix Astragali 27 weight portion, Caulis Spatholobi 22 weight portion, Semen Cuscutae 24 weight portion, Fructus Lycii 31 weight portion, Radix Dipsaci 12 weight portion, Radix Morindae Officinalis 16 weight portion, Radix Rehmanniae Preparata 37 weight portion, Fructus Rubi 32 weight portion, Semen vignae sinensis 15 weight portion, Herba Orobanches 16 weight portion, Herba Pyrolae 20 weight portion, Herba Gonostegiae hirtae 17 weight portion, Herba Cynomorii 21 weight portion, Herba Orchidis Latifoliae 22 weight portion, metapanax of araliaceae 18 weight portion, Herba Strigae Asiaticae 23 weight portion, Fructus Polygoni Orientalis 16 weight portion, Rhizoma Cyperi 32 weight portion, Radix Triplostegiae Grandiflorae 23 weight portion, Herba hypoxis aureae 11 weight portion, Rhizomadioscoreae 30 weight portion, Radix Kadsurae Coccineae 13 weight portion, Fructus Corni 24 weight portion, Endoconcha Sepiae 28 weight portion, Herba Acalyphae 10 weight portion, Rhizoma Cimicifugae 23 weight portion, Radix Glycyrrhizae 26 weight portion and Pericarpium Granati 15 weight portion.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: the Radix Astragali 41 weight portion, Caulis Spatholobi 25 weight portion, Semen Cuscutae 21 weight portion, Fructus Lycii 33 weight portion, Radix Dipsaci 20 weight portion, Radix Morindae Officinalis 20 weight portion, Radix Rehmanniae Preparata 28 weight portion, Fructus Rubi 22 weight portion, Semen vignae sinensis 24 weight portion, Herba Orobanches 12 weight portion, Herba Pyrolae 12 weight portion, Herba Gonostegiae hirtae 23 weight portion, Herba Cynomorii 14 weight portion, Herba Orchidis Latifoliae 17 weight portion, metapanax of araliaceae 14 weight portion, Herba Strigae Asiaticae 20 weight portion, Fructus Polygoni Orientalis 26 weight portion, Rhizoma Cyperi 27 weight portion, Radix Triplostegiae Grandiflorae 26 weight portion, Herba hypoxis aureae 16 weight portion, Rhizomadioscoreae 21 weight portion, Radix Kadsurae Coccineae 16 weight portion, Fructus Corni 14 weight portion, Endoconcha Sepiae 29 weight portion, Herba Acalyphae 16 weight portion, Rhizoma Cimicifugae 12 weight portion, Radix Glycyrrhizae 18 weight portion and Pericarpium Granati 12 weight portion.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: the Radix Astragali 31 weight portion, Caulis Spatholobi 18 weight portion, Semen Cuscutae 30 weight portion, Fructus Lycii 25 weight portion, Radix Dipsaci 18 weight portion, Radix Morindae Officinalis 22 weight portion, Radix Rehmanniae Preparata 33 weight portion, Fructus Rubi 29 weight portion, Semen vignae sinensis 19 weight portion, Herba Orobanches 21 weight portion, Herba Pyrolae 18 weight portion, Herba Gonostegiae hirtae 15 weight portion, Herba Cynomorii 16 weight portion, Herba Orchidis Latifoliae 15 weight portion, metapanax of araliaceae 23 weight portion, Herba Strigae Asiaticae 17 weight portion, Fructus Polygoni Orientalis 24 weight portion, Rhizoma Cyperi 35 weight portion, Radix Triplostegiae Grandiflorae 17 weight portion, Herba hypoxis aureae 9 weight portion, Rhizomadioscoreae 28 weight portion, Radix Kadsurae Coccineae 10 weight portion, Fructus Corni 20 weight portion, Endoconcha Sepiae 17 weight portion, Herba Acalyphae 9 weight portion, Rhizoma Cimicifugae 22 weight portion, Radix Glycyrrhizae 27 weight portion and Pericarpium Granati 8 weight portion.
When the dosage form of described Chinese medicine is honey refining pill, its preparation method comprises the following steps:
Step 1: first by ratio mixing described in the Radix Astragali, Caulis Spatholobi, Semen Cuscutae, Fructus Lycii, Radix Dipsaci, Radix Morindae Officinalis, Radix Rehmanniae Preparata, Fructus Rubi, Semen vignae sinensis and Herba Orobanches, distillation crystallization obtains powder;
Step 2: get surplus stock medical material again and mix in described ratio, add relative to 83-94% soak with ethanol 1-2 hour of mixture 2-6 times amount, heating extraction 2 times, each 1-1.5 hour, merge extractive liquid, 124-150 order filter, be the ultrafiltration post ultrafiltration of 4400-98000 again through the molecular weight that dams, when ultrafiltrate is evaporated to 87 DEG C, relative density is the extractum of 1.04, becomes component 1;
Step 3: step 2 Chinese medicine slag is added 4-6 times amount water soaking 1-2.5 hour, extract 1 time, extraction time is 1.5-2 hour, and thickening filtration is extractum shape, is component 2.
Step 4: said components 1 and component 2 two kinds of extractum are condensed into pasty state, add the powder that step 1 obtains, add Mel and be twisted into pill.
When the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 ~ 5 times is the ethanol of 85% ~ 90%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 3 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 ~ 3 hours, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.15 ~ 0.3 times of lactose, the starch of 0.2 ~ 0.35 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.025 ~ 0.04 times of magnesium stearate, granulate, tabletting, makes.
When the dosage form of described Chinese medicine is decoction, its preparation method comprises the following steps:
Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-10 hour;
Step 2: be placed in by purple casserole on fire, after intense fire boils, uses slow fire instead and decocts 30-50 minute slowly, filters, obtains filtrate a, for subsequent use;
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour;
Step 4: be placed in by purple casserole on fire, after intense fire boils, uses slow fire instead and decocts 25-35 minute slowly, filters, obtains filtrate b, mixed by filtrate a and filtrate b.
 
For solving the problems of the technologies described above, the present invention reoffers a kind of Chinese medicine for the treatment of renal deficiency type uterine prolapse, and pharmaceutical dosage form can be: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster, syrup, powder.
Medicine is when decocting decoction and taking, and every day 1 dose, decocting takes at twice, and every 7 days is a course for the treatment of; When this Chinese medicine is patch use, 1 time on the one, every 7 days is a course for the treatment of; When this Chinese medicine be capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, tablet, honey pill agent use time, three times on the one, every 7 days is a course for the treatment of.
The beneficial effect that technical scheme of the present invention is brought is: Chinese medicine of the present invention has QI invigorating and promotes, and effect that kidney tonifying takes off admittedly, cures mainly renal deficiency type uterine prolapse.Utilize Traditional Chinese medical theory, great attention to whole idea, and processing technology is easy, the little and convenient drug administration of toxic and side effects, focus of going directly, the course for the treatment of is shorter, not easily recurs after healing, and medicament is easy to manufacture, with low cost.
 
Detailed description of the invention
uterine prolapse belongs to the traditional Chinese medical science " prolapse of the uterus ", " prolapse of the uterus " category.The cause of disease mostly is that delivery and feed infant is too much, and during childbirth, stages of labor is long, overexertion or deal with improperly, damages collaterals of the uterus; Or puerperal participate in heavy physical labour too early, after standing and position of squatting for a long time; Or have a delicate constitution, chronic cough, constipation, diarrhoea etc. cause abdominal pressure to increase, and make pelvic diaphragm muscle and fascia overextension or damage.Chinese medicine, when setting forth its pathomechanism, from " insufficiency of the spleen fall ", " suffered from a deficiency of the kidney and is lost solid ".Patient, because of overstrain, fecund, damages spleen kidney, and the deficiency of spleen-QI then middle deficiency of vital energy is weak, and QI collapse caused by exhaustion of QI of the spleen and kidney does not rise; Kidney loses, and instability of kidney-QI, causes dai channel and fail to keep an appointment, the debility of CHONG and REN meridians, unablely maintains uterus, and uterine ligaments relaxes, and uterus loses suspention and sends out primary disease.Say as " all source of disease marquis opinions ": " collaterals of the uterus damages, and sub-deficiency of five ZANG-organs is cold, and gas punching then makes the prolapse of the uterus go out, de-under meaning.Also firmly to lay down because of product gas and cloudy lower de-person is had.”
Therefore, the present invention treats renal deficiency type uterine prolapse and promotes with QI invigorating, kidney tonifying takes off admittedly for primary treatment principle, selects prescription: the Radix Astragali, Caulis Spatholobi, Semen Cuscutae, Fructus Lycii, Radix Dipsaci, Radix Morindae Officinalis, Radix Rehmanniae Preparata, Fructus Rubi, Semen vignae sinensis, Herba Orobanches, Herba Pyrolae, Herba Gonostegiae hirtae, Herba Cynomorii, Herba Orchidis Latifoliae, metapanax of araliaceae, Herba Strigae Asiaticae, Fructus Polygoni Orientalis, Rhizoma Cyperi, Radix Triplostegiae Grandiflorae, Herba hypoxis aureae, Rhizomadioscoreae, Radix Kadsurae Coccineae, Fructus Corni, Endoconcha Sepiae, Herba Acalyphae, Rhizoma Cimicifugae, Radix Glycyrrhizae and Pericarpium Granati.
Wherein, the Radix Astragali, can invigorating the spleen and replenishing QI, and Radix Triplostegiae Grandiflorae, Herba hypoxis aureae, Rhizomadioscoreae are with using; Yang invigorating consolidating superficial resistance; Caulis Spatholobi, Radix Kadsurae Coccineae nourshing blood and promoting blood circulation; Compatibility Rhizoma Cyperi inrigorating qi and promoting blood circulation; Semen Cuscutae, Fructus Lycii, Radix Dipsaci, Radix Morindae Officinalis, Radix Rehmanniae Preparata, Fructus Rubi, Semen vignae sinensis, Herba Orobanches, Herba Pyrolae, Herba Cynomorii, Herba Orchidis Latifoliae can life essence-filling, marrow-benefitting, the kidney invigorating; Herba Gonostegiae hirtae, metapanax of araliaceae heat-clearing and toxic substances removing; Herba Strigae Asiaticae, Fructus Polygoni Orientalis spleen invigorating removing food stagnancy; Fructus Corni can nourishing the liver arresting seminal emission, compatible to restrain the uterus that ascending prolapses with Endoconcha Sepiae, Fructus Rubi, Herba Acalyphae, Pericarpium Granati etc.; Rhizoma Cimicifugae can be used for middle gas fall into, chronic diarrhea proctoptosis, uterine prolapse etc.; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.All medicines share, and QI invigorating of gathering altogether promotes, the merit that kidney tonifying is admittedly de-.
Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:
The Radix Astragali: sweet, tepor; Return lung, spleen, liver, kidney channel.Essentials of Matea Medica: " Radix Astragali, life consolidating superficial resistance losslessly can be sent out, and have antiperspirant to stop; Process with invigorating middle warmer, beneficial vigour, strong taste.Hemopoietic, granulation promoting, evacuation of pus expelling the toxic substance from the body with tonic, carbuncle sore panacea.Variola does not rise, and yang deficiency should it without hot person." " book on Chinese herbal medicine justice ": " replenishing vital QI with drugs of warm nature taste, all middle gas is depressed, and spleen soil is weak, and the person of sinking is the most suitable for clearing heat in QI system for the Radix Astragali, soil in tonification.Its skin goes directly the skin table muscle of people, and solid protection defends sun, and enriching table point, is its speciality, so all diseases of exterior deficiency, and the most refreshing agent." function consolidating superficial resistance arresting sweating, inducing diuresis to remove edema, the evacuation of pus of holder skin ulcer, regulating fluid apssage.
Caulis Spatholobi: bitter, sweet, temperature.Return liver, kidney channel.Enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.
Semen Cuscutae: abnormal smells from the patient is pungent, sweet, flat nontoxic." not Lu ": " support flesh reinforcing YIN-essence, hard muscles and bones, stem invasion by pathogenic cold, essence is from going out, and drown and have the heeltap, bitter taste is yearningly dry, and cold blood is long-pending." " Japan hanako materia medica ": " mends five kinds of strain and seven kinds of impairment, controls and lets out essence, hematuria, profit cardiopulmonary." the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.The waist knee joint muscles and bones being applicable to deficiency of the liver and kindey is ached, the diseases such as legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, dripping urination, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion.Semen Cuscutae is improved the effect of fruit bat Sexual potency, and its mating rate is obviously increased, and its effect is strong and weak becomes positive correlation with administration concentration.Preserved material, to anesthetized dog intravenous injection, has the effect making blood pressure drops." must book on Chinese herbal medicine be joined ": " anemia of pregnant woman, metrorrhagia, postcoital protrusion, constipation, kidney have fire, deficiency of YIN fire dynamic, six forbiddings.
Fructus Lycii: sweet is flat.Folium Lycii: bitter, sweet; Cool in nature.Enter liver, kidney, lung meridian." Treatise on Dietetic Therapy ": " hard muscle is always resistance to, and except wind, tonification muscles and bones, the beneficial people of energy, removes asthenia." control hepatic and renal YIN deficiency, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, impotence and seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.
Radix Dipsaci: bitter, pungent, tepor.Return liver, kidney channel.Invigorating the liver and kidney, bone and muscle strengthening, continuous injured, only metrorrhagia.For soreness of the waist and knees, rheumatic arthralgia, metrorrhagia, vaginal bleeding during pregnancy, injury from falling down.Prepared RADIX DIPSACI with yellow rice wine is used for rheumatic arthralgia, injury from falling down.Prepared RADIX DIPSACI with salt solution is used for soreness of the waist and knees.
Radix Morindae Officinalis: sweet, pungent, tepor.Return kidney, Liver Channel.Kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, cold womb is infertile, menoxenia, and few abdomen cold type of pain, rheumatic arthralgia, muscles and bones flaccidity is soft.
Fructus Rubi: sweet acid; Flat; Nontoxic.Return liver; Kidney channel.The liver and the kidney tonifying, controlling nocturnal emission with astringent drugs reducing urination, improving eyesight.Main impotence and premature ejaculation, emission and spermatorrhea, cold womb is infertile, and leukorrhagia is rare clearly, frequent micturition incontinence of urine, and blurred vision is dark, early whitening of beard and hair.
Semen vignae sinensis: sweet in the mouth; Salty; Property is put down.Return spleen; Kidney channel.Invigorating spleen to remove dampness; The kidney invigorating arresting seminal emission.Main weakness of the spleen and stomach; Have loose bowels; Dysentery; Tell inverse; Quench one's thirst; Lumbago due to renal deficiency; Seminal emission; Leucorrhea; Nebulousurine; Frequent micturition.
Herba Orobanches: sweet in the mouth; Warm in nature.Return kidney; Liver; Large intestine channel.Kidney invigorating and YANG supporting; Bone and muscle strengthening; Intestine moistening.Main impotence due to deficiency of the kidney; Seminal emission; Cold womb is infertile; Rickets of child; Chills and pain of the waist and kness; Dish bone is weak; Dryness of the intestine constipation.
Herba Pyrolae: sweet, bitter, temperature.Return liver, kidney channel.Wind-damp dispelling, bone and muscle strengthening, hemostasis.For rheumatic arthralgia, weakness of the waist and knees, menorrhagia, chronic cough due to asthenia of viscera.
Herba Gonostegiae hirtae: sweet; Micro-hardship; Cool in nature.Heat-clearing and toxic substances removing; Spleen invigorating removing food stagnancy; Inducing diuresis and reducing edema; Dissipating blood stasis stops blooding.Main acute mastitis; Toxic swelling; Dysentery; Dyspepsia; Abdominal pain due to retention of food; Glycoside amasss; Leukorrhagia; Edema; Dysuria; Dysmenorrhea; Traumatic injury; Hemoptysis; Spit blood; Traumatic hemorrhage.
Herba Cynomorii: sweet, temperature.Return spleen, kidney, large intestine channel.Kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.Soft for waist knee joint flaccidity, sexual impotence spermatorrhea, dryness of the intestine constipation.
Herba Orchidis Latifoliae: sweet, flat.Heart tonifying, the kidney invigorating, promotes the production of body fluid, and quenches the thirst, strengthening the spleen and stomach.Hot-tempered thirsty, anorexia, menoxenia.Asthenia anemia, dizzy, dim eyesight.
Metapanax of araliaceae: sweet in the mouth; Bitter; Cool in nature.Heat-clearing and toxic substances removing; Relaxing muscles and tendons to promote blood circulation.Main laryngopharynx swelling and pain; Conjunctival congestion and swelling pain; Dyspepsia; Menoxenia; Lumbago, skelalgia of rheumatism; Traumatic injury; Fracture.
Herba Strigae Asiaticae: sweet in the mouth; Micro-hardship; Cool in nature.Return liver; Spleen; Stomach warp.Spleen invigorating removing food stagnancy; Heat clearing away parasite killing.Main child dyspepsia caused by overeating; Infantile malnutrition general edema with yellowish skin; Nyctalopia; Summer fever; Diarrhoea; Hepatitis.
Fructus Polygoni Orientalis: salty, is slightly cold.Return liver, stomach warp.Loose blood eliminating mass, removing food stagnancy pain relieving.For lump in the abdomen mass in the abdomen, goiter swells and ache, and food stagnation does not disappear, epigastric distending pain.
Rhizoma Cyperi: pungent, micro-hardship, micro-sweet, flat.Return liver, spleen, tri-jiao channel.Promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.
Radix Triplostegiae Grandiflorae: sweet, micro-hardship is flat.Tonifying speen and tonifying kidney, promoting blood flow to regulate menstruation, only metrorrhagia, detoxifies, enriches blood, invigorate blood circulation, QI invigorating.。For lumbago due to renal deficiency, anemia, cough, seminal emission, sexual impotence, rheumatic arthritis, menoxenia, vicarious menstruation, metrorrhagia, leukorrhagia, infertility.External is stopped blooding.
Herba hypoxis aureae: sweet, micro-pungent, temperature.Warming the kidney to invigorate YANG, QI invigorating.Lumbago due to renal deficiency, colicky.
Rhizomadioscoreae: flat, sweet, nontoxic.Return lung, spleen, kidney, stomach.Spleen invigorating, thick the intestines and stomach, tonifying the lung, kidney tonifying.Diarrhea due to hypofunction of the spleen, chronic dysentery, cough due to consumptive disease, seminal emission leukorrhagia, frequent micturition, quenches one's thirst, uterine prolapse.
Radix Kadsurae Coccineae: pungent micro-hardship, temperature.Hemostasis, enriches blood.Control knife injury, uterine prolapse.Promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis, detumescence of dispeling the wind.Control chronic gastritis, acute gastroenteritis, gastric and duodenal ulcers, rheumatic ostalgia, traumatic injury paralysis pain, premenstrual abdominal pain, puerperal the stasis of blood pain, edema.
Fructus Corni: sour, puckery, tepor.Return liver, kidney channel.Liver and kidney tonifying, essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating is collapsed.Interior-heat is quenched one's thirst.
Endoconcha Sepiae: salty in the mouth, puckery, slightly warm in nature.Return liver, kidney channel.Compendium of Material Medica: " main woman's blood depletion is sick, impairing the liver, hemoptysis hematochezia, and treating malaria disappears wart.Endoconcha Sepiae grinds deposited children's's chancre into powder, and variola is smelly rotten, husband's erosion of vulva, and burn is got injured by a fall hemorrhage." effect astringing to arrest bleeding, treating spontaneous emission and leukorrhagia, antacid sore.Calcium carbonate contained in Os Sepiae, can do antacid agent.
Herba Acalyphae: bitter, puckery, cool.Heat-clearing and toxic substances removing, removing food stagnancy, dysentery relieving, hemostasis.For enteritis, bacillary dysentery, amebic dysentery, infantile malnutrition, hepatitis, malaria, spits blood, epistaxis, and hematuria, has blood in stool, metrorrhagia; Carbuncle furuncle infections is controlled in external, traumatic hemorrhage, eczema, dermatitis, venom.
Rhizoma Cimicifugae: pungent, micro-sweet, is slightly cold.Return lung, spleen, stomach, large intestine channel.Deliver rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy.For headache due to pathogenic wind-heat, toothache, aphtha, laryngopharynx swelling and pain, measles without adequate eruption, YANG toxin syndrome sends out speckle; Proctoptosis, uterine prolapse.
Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Pericarpium Granati: sour, puckery, temperature.Return large intestine channel.Relieving diarrhea with astringents, hemostasis, anthelmintic.For chronic diarrhea, chronic dysentery, has blood in stool, proctoptosis, metrorrhagia, leucorrhea, abdominal pain due to worm stagnation.
Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material is preferably: Radix Astragali 25-44 weight portion, Caulis Spatholobi 16-28 weight portion, Semen Cuscutae 20-33 weight portion, Fructus Lycii 23-35 weight portion, Radix Dipsaci 10-22 weight portion, Radix Morindae Officinalis 14-25 weight portion, Radix Rehmanniae Preparata 28-40 weight portion, Fructus Rubi 22-34 weight portion, Semen vignae sinensis 14-27 weight portion, Herba Orobanches 11-23 weight portion, Herba Pyrolae 10-22 weight portion, Herba Gonostegiae hirtae 13-25 weight portion, Herba Cynomorii 12-24 weight portion, Herba Orchidis Latifoliae 13-26 weight portion, metapanax of araliaceae 13-25 weight portion, Herba Strigae Asiaticae 14-25 weight portion, Fructus Polygoni Orientalis 13-28 weight portion, Rhizoma Cyperi 25-38 weight portion, Radix Triplostegiae Grandiflorae 15-30 weight portion, Herba hypoxis aureae 8-19 weight portion, Rhizomadioscoreae 19-32 weight portion, Radix Kadsurae Coccineae 8-18 weight portion, Fructus Corni 14-27 weight portion, Endoconcha Sepiae 16-31 weight portion, Herba Acalyphae 9-20 weight portion, Rhizoma Cimicifugae 12-30 weight portion, Radix Glycyrrhizae 14-30 weight portion and Pericarpium Granati 7-17 weight portion.
Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Radix Astragali 27-41 weight portion, Caulis Spatholobi 18-25 weight portion, Semen Cuscutae 21-30 weight portion, Fructus Lycii 25-33 weight portion, Radix Dipsaci 12-20 weight portion, Radix Morindae Officinalis 16-22 weight portion, Radix Rehmanniae Preparata 28-37 weight portion, Fructus Rubi 22-32 weight portion, Semen vignae sinensis 15-24 weight portion, Herba Orobanches 12-21 weight portion, Herba Pyrolae 12-20 weight portion, Herba Gonostegiae hirtae 15-23 weight portion, Herba Cynomorii 14-21 weight portion, Herba Orchidis Latifoliae 15-22 weight portion, metapanax of araliaceae 14-23 weight portion, Herba Strigae Asiaticae 17-23 weight portion, Fructus Polygoni Orientalis 16-26 weight portion, Rhizoma Cyperi 27-35 weight portion, Radix Triplostegiae Grandiflorae 17-26 weight portion, Herba hypoxis aureae 9-16 weight portion, Rhizomadioscoreae 21-30 weight portion, Radix Kadsurae Coccineae 10-16 weight portion, Fructus Corni 14-24 weight portion, Endoconcha Sepiae 17-29 weight portion, Herba Acalyphae 9-16 weight portion, Rhizoma Cimicifugae 12-23 weight portion, Radix Glycyrrhizae 18-27 weight portion and Pericarpium Granati 8-15 weight portion.
Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably again: the Radix Astragali 27 weight portion, Caulis Spatholobi 22 weight portion, Semen Cuscutae 24 weight portion, Fructus Lycii 31 weight portion, Radix Dipsaci 12 weight portion, Radix Morindae Officinalis 16 weight portion, Radix Rehmanniae Preparata 37 weight portion, Fructus Rubi 32 weight portion, Semen vignae sinensis 15 weight portion, Herba Orobanches 16 weight portion, Herba Pyrolae 20 weight portion, Herba Gonostegiae hirtae 17 weight portion, Herba Cynomorii 21 weight portion, Herba Orchidis Latifoliae 22 weight portion, metapanax of araliaceae 18 weight portion, Herba Strigae Asiaticae 23 weight portion, Fructus Polygoni Orientalis 16 weight portion, Rhizoma Cyperi 32 weight portion, Radix Triplostegiae Grandiflorae 23 weight portion, Herba hypoxis aureae 11 weight portion, Rhizomadioscoreae 30 weight portion, Radix Kadsurae Coccineae 13 weight portion, Fructus Corni 24 weight portion, Endoconcha Sepiae 28 weight portion, Herba Acalyphae 10 weight portion, Rhizoma Cimicifugae 23 weight portion, Radix Glycyrrhizae 26 weight portion and Pericarpium Granati 15 weight portion.
Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: the Radix Astragali 41 weight portion, Caulis Spatholobi 25 weight portion, Semen Cuscutae 21 weight portion, Fructus Lycii 33 weight portion, Radix Dipsaci 20 weight portion, Radix Morindae Officinalis 20 weight portion, Radix Rehmanniae Preparata 28 weight portion, Fructus Rubi 22 weight portion, Semen vignae sinensis 24 weight portion, Herba Orobanches 12 weight portion, Herba Pyrolae 12 weight portion, Herba Gonostegiae hirtae 23 weight portion, Herba Cynomorii 14 weight portion, Herba Orchidis Latifoliae 17 weight portion, metapanax of araliaceae 14 weight portion, Herba Strigae Asiaticae 20 weight portion, Fructus Polygoni Orientalis 26 weight portion, Rhizoma Cyperi 27 weight portion, Radix Triplostegiae Grandiflorae 26 weight portion, Herba hypoxis aureae 16 weight portion, Rhizomadioscoreae 21 weight portion, Radix Kadsurae Coccineae 16 weight portion, Fructus Corni 14 weight portion, Endoconcha Sepiae 29 weight portion, Herba Acalyphae 16 weight portion, Rhizoma Cimicifugae 12 weight portion, Radix Glycyrrhizae 18 weight portion and Pericarpium Granati 12 weight portion.
Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: the Radix Astragali 31 weight portion, Caulis Spatholobi 18 weight portion, Semen Cuscutae 30 weight portion, Fructus Lycii 25 weight portion, Radix Dipsaci 18 weight portion, Radix Morindae Officinalis 22 weight portion, Radix Rehmanniae Preparata 33 weight portion, Fructus Rubi 29 weight portion, Semen vignae sinensis 19 weight portion, Herba Orobanches 21 weight portion, Herba Pyrolae 18 weight portion, Herba Gonostegiae hirtae 15 weight portion, Herba Cynomorii 16 weight portion, Herba Orchidis Latifoliae 15 weight portion, metapanax of araliaceae 23 weight portion, Herba Strigae Asiaticae 17 weight portion, Fructus Polygoni Orientalis 24 weight portion, Rhizoma Cyperi 35 weight portion, Radix Triplostegiae Grandiflorae 17 weight portion, Herba hypoxis aureae 9 weight portion, Rhizomadioscoreae 28 weight portion, Radix Kadsurae Coccineae 10 weight portion, Fructus Corni 20 weight portion, Endoconcha Sepiae 17 weight portion, Herba Acalyphae 9 weight portion, Rhizoma Cimicifugae 22 weight portion, Radix Glycyrrhizae 27 weight portion and Pericarpium Granati 8 weight portion.
Wherein, when the dosage form of Chinese medicine is honey refining pill, its preparation method comprises the following steps:
Step 1: first by ratio mixing described in the Radix Astragali, Caulis Spatholobi, Semen Cuscutae, Fructus Lycii, Radix Dipsaci, Radix Morindae Officinalis, Radix Rehmanniae Preparata, Fructus Rubi, Semen vignae sinensis and Herba Orobanches, distillation crystallization obtains powder;
Step 2: get surplus stock medical material again and mix in described ratio, add relative to 83-94% soak with ethanol 1-2 hour of mixture 2-6 times amount, heating extraction 2 times, each 1-1.5 hour, merge extractive liquid, 124-150 order filter, be the ultrafiltration post ultrafiltration of 4400-98000 again through the molecular weight that dams, when ultrafiltrate is evaporated to 87 DEG C, relative density is the extractum of 1.04, becomes component 1;
Step 3: step 2 Chinese medicine slag is added 4-6 times amount water soaking 1-2.5 hour, extract 1 time, extraction time is 1.5-2 hour, and thickening filtration is extractum shape, is component 2.
Step 4: said components 1 and component 2 two kinds of extractum are condensed into pasty state, add the powder that step 1 obtains, add Mel and be twisted into pill.
Wherein, when the dosage form of Chinese medicine is tablet, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 ~ 5 times is the ethanol of 85% ~ 90%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 3 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 ~ 3 hours, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.15 ~ 0.3 times of lactose, the starch of 0.2 ~ 0.35 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.025 ~ 0.04 times of magnesium stearate, granulate, tabletting, makes.
Wherein, when the dosage form of Chinese medicine is decoction, its preparation method comprises the following steps:
Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-10 hour;
Step 2: be placed in by purple casserole on fire, after intense fire boils, uses slow fire instead and decocts 30-50 minute slowly, filters, obtains filtrate a, for subsequent use;
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour;
Step 4: be placed in by purple casserole on fire, after intense fire boils, uses slow fire instead and decocts 25-35 minute slowly, filters, obtains filtrate b, mixed by filtrate a and filtrate b.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
         
Embodiment 1 honey refining of the present invention pill
Get Radix Astragali 27g, Caulis Spatholobi 22g, Semen Cuscutae 24g, Fructus Lycii 31g, Radix Dipsaci 12g, Radix Morindae Officinalis 16g, Radix Rehmanniae Preparata 37g, Fructus Rubi 32g, Semen vignae sinensis 15g, Herba Orobanches 16g, Herba Pyrolae 20g, Herba Gonostegiae hirtae 17g, Herba Cynomorii 21g, Herba Orchidis Latifoliae 22g, metapanax of araliaceae 18g, Herba Strigae Asiaticae 23g, Fructus Polygoni Orientalis 16g, Rhizoma Cyperi 32g, Radix Triplostegiae Grandiflorae 23g, Herba hypoxis aureae 11g, Rhizomadioscoreae 30g, Radix Kadsurae Coccineae 13g, Fructus Corni 24g, Endoconcha Sepiae 28g, Herba Acalyphae 10g, Rhizoma Cimicifugae 23g, Radix Glycyrrhizae 26g and Pericarpium Granati 15g.
Its preparation method comprises the following steps:
Step 1: first by ratio mixing described in the Radix Astragali, Caulis Spatholobi, Semen Cuscutae, Fructus Lycii, Radix Dipsaci, Radix Morindae Officinalis, Radix Rehmanniae Preparata, Fructus Rubi, Semen vignae sinensis and Herba Orobanches, distillation crystallization obtains powder;
Step 2: get surplus stock medical material again and mix in described ratio, add 94% soak with ethanol 2 hours, the heating extraction 2 times relative to mixture 3 times amount, each 1.5 hours, merge extractive liquid, 150 orders filter, be the ultrafiltration post ultrafiltration of 98000 again through the molecular weight that dams, when ultrafiltrate is evaporated to 87 DEG C, relative density is the extractum of 1.04, becomes component 1;
Step 3: step 2 Chinese medicine slag is added 5 times amount water soaking 2 hours, extract 1 time, extraction time is 2 hours, and thickening filtration is extractum shape, is component 2;
Step 4: said components 1 and component 2 two kinds of extractum are condensed into pasty state, add the powder that step 1 obtains, add Mel and be twisted into pill.
 
Embodiment 2 tablet of the present invention
Get Radix Astragali 41g, Caulis Spatholobi 25g, Semen Cuscutae 21g, Fructus Lycii 33g, Radix Dipsaci 20g, Radix Morindae Officinalis 20g, Radix Rehmanniae Preparata 28g, Fructus Rubi 22g, Semen vignae sinensis 24g, Herba Orobanches 12g, Herba Pyrolae 12g, Herba Gonostegiae hirtae 23g, Herba Cynomorii 14g, Herba Orchidis Latifoliae 17g, metapanax of araliaceae 14g, Herba Strigae Asiaticae 20g, Fructus Polygoni Orientalis 26g, Rhizoma Cyperi 27g, Radix Triplostegiae Grandiflorae 26g, Herba hypoxis aureae 16g, Rhizomadioscoreae 21g, Radix Kadsurae Coccineae 16g, Fructus Corni 14g, Endoconcha Sepiae 29g, Herba Acalyphae 16g, Rhizoma Cimicifugae 12g, Radix Glycyrrhizae 18g and Pericarpium Granati 12g.
Its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 90%, reflux 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 400 object micropowders;
3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.3 times, 0.3 times of lactose, the starch of 0.35 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.04 times of magnesium stearate, granulate, tabletting, makes.
 
Embodiment 3 decoction of the present invention
Get Radix Astragali 31g, Caulis Spatholobi 18g, Semen Cuscutae 30g, Fructus Lycii 25g, Radix Dipsaci 18g, Radix Morindae Officinalis 22g, Radix Rehmanniae Preparata 33g, Fructus Rubi 29g, Semen vignae sinensis 19g, Herba Orobanches 21g, Herba Pyrolae 18g, Herba Gonostegiae hirtae 15g, Herba Cynomorii 16g, Herba Orchidis Latifoliae 15g, metapanax of araliaceae 23g, Herba Strigae Asiaticae 17g, Fructus Polygoni Orientalis 24g, Rhizoma Cyperi 35g, Radix Triplostegiae Grandiflorae 17g, Herba hypoxis aureae 9g, Rhizomadioscoreae 28g, Radix Kadsurae Coccineae 10g, Fructus Corni 20g, Endoconcha Sepiae 17g, Herba Acalyphae 9g, Rhizoma Cimicifugae 22g, Radix Glycyrrhizae 27g and Pericarpium Granati 8g.
Its preparation method comprises the following steps:
Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2cm, soak 3 hours;
Step 2: be placed in by purple casserole on fire, after intense fire boils, uses slow fire instead and decocts 30 minutes slowly, filters, obtains filtrate a, for subsequent use;
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2cm, soaks 3 hours;
Step 4: be placed in by purple casserole on fire, after intense fire boils, uses slow fire instead and decocts 30 minutes slowly, filters, obtains filtrate b, mixed by filtrate a and filtrate b.
 
Toxicity test:
Acute toxicity test: application NIH mice 60, SPF level, male and female half and half, body weight 17 ~ 24g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; The honey refining pill prepared by embodiments of the invention 1 is dissolved in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage honey refining of the present invention pill LD50>28.7 crude drug/kg, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage Chinese medicine of the present invention is 745 times of quantity.Therefore the honey refining pill acute toxicity of the embodiment of the present invention 1 is low, clinical drug safety.
Long term toxicity test: the tablet of the embodiment of the present invention 2 is pressed 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Long term toxicity test: the decoction of the embodiment of the present invention 3 is pressed 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
 
Clinical data:
Choose 158 cases and all carry out self-Out-patient Department renal deficiency type uterine prolapsed patient, the age is between 26-50 year; Be women, the course of disease, between 5-19, is non-symptomatic bulging, wherein I degree of uterine prolapse person 37 example, II degree of uterine prolapse person 121 example.Patient is divided into four groups at random, and four groups of patients through statistical test zero difference (P > 0.05), have comparability in age, the course of disease, clinical manifestation etc.
Honey refining pill treatment group: 39 people.
Tablet in treatment group: 39 people.
Decoction treatment group: 40 people.
Matched group: 40 people.
 
Diagnostic criteria:
By the diagnostic criteria that State Administration of Traditional Chinese Medicine formulates.Uterus declines from normal position along vagina, reaches ischial spine below horizontal to cervical orifice, notably all deviates from outside vaginal orifice, with diseases such as lower abdomen dull pain, falling inflations.
Gynecologial examination: cervix uteri hangs down to below ischial spine plane, but person is I degree to be no more than vaginal orifice; Cervix uteri and part body of uterus emerge in outside vaginal orifice, are often II degree with vagina front and rear wall bulging person; Cervix uteri and palace body all emerge in outside vaginal orifice, are often III degree with vagina front and rear wall bulging person.
The dialectical renal deficiency type of Chinese medicine: main manifestations is that uterus moves down, or deviates from outside vaginal orifice, lower abdomen drops, frequent micturition, waist soreness, dizziness and tinnitus, light red tongue, thin fur, deep-thready pulse.
Therapeutic Method:
Honey refining pill treatment group: the honey refining pill of the oral embodiment of the present invention 1, every day 3 times, each 47 days is 1 course for the treatment of.
Tablet in treatment group: the tablet of the oral embodiment of the present invention 2, every day 3 times, each 37 days is 1 course for the treatment of.
Decoction treatment group: the decoction using the embodiment of the present invention 3, every day 1 dose, sooner or later taking for twice, 7 days is 1 course for the treatment of.
Contrast groups: adopt supporting treatment, strengthens nutrition, suitably has a rest, avoids heavy physical labour, keeps free movement of the bowels, strengthens pelvic diaphragm muscle exercise; It within 7 days, is 1 course for the treatment of.
Four groups all judge curative effect after 2 courses for the treatment of of treatment.
 
Efficacy assessment standard:
The criterion of therapeutical effect evaluation of formulating by State Administration of Traditional Chinese Medicine,
Recovery from illness: recover of uterus normal position, half a year does not recur;
Take a turn for the better: cervix uteri and palace body were received to last time, but did not return to normal position;
Invalid: symptom and sign unchanged.
 
Therapeutic outcome:
See table 1 and table 2, as can be seen from Table 1, adopt treatment by Chinese herbs renal deficiency type of the present invention uterine prolapse, relative to the supporting treatment of contrast groups on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt treatment by Chinese herbs renal deficiency type of the present invention uterine prolapse, relative to the supporting treatment of contrast groups, treatment the course for the treatment of on significantly shorten.
After table 1 Four composition does not treat two courses for the treatment of, Clinical efficacy comparison is routine
Group Number of cases Recovery from illness Take a turn for the better Invalid Total effective rate
Honey refining pill treatment group 39 20 17 2 94.9%
Tablet in treatment group 39 20 16 3 92.3%
Decoction treatment group 40 21 17 2 95.0%
Matched group 40 3 18 19 52.5%
Table 2 Four composition does not treat recovery from illness and the number taken a turn for the better and time comparative example (%) after two courses for the treatment of
Group Number of cases 1st course for the treatment of 2nd course for the treatment of
Honey refining pill treatment group 37 15(40.5%) 22(59.5%)
Tablet in treatment group 36 14(38.9%) 22(61.1%)
Decoction treatment group 38 16(42.1%) 22(57.9%)
Matched group 21 7(33.3%) 14(66.7%)
According to the clinical statistics in above table, Chinese medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect.
 
Model case: land, female, 37 years old, in June, 2012 went to a doctor.Main suit's frequent micturition, dizziness and tinnitus, waist soreness, lower abdomen drop 8 years, look into: II degree of uterine prolapse, light red tongue, thin fur, deep-thready pulse.Diagnosis: II degree of uterine prolapse, Chinese medicine is dialectical belongs to renal deficiency type.Use Chinese medicine preparation embodiment 1 of the present invention honey refining pill, every day 3 times, 1 time 4, treat 4 days, symptom alleviates, and continues to take medicine 3 days, fully recover, follow up a case by regular visits to and do not recur for 1 year.
 
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (9)

1. treat the Chinese medicine of renal deficiency type uterine prolapse for one kind, it is characterized in that, comprise following raw medicinal material: the Radix Astragali, Caulis Spatholobi, Semen Cuscutae, Fructus Lycii, Radix Dipsaci, Radix Morindae Officinalis, Radix Rehmanniae Preparata, Fructus Rubi, Semen vignae sinensis, Herba Orobanches, Herba Pyrolae, Herba Gonostegiae hirtae, Herba Cynomorii, Herba Orchidis Latifoliae, metapanax of araliaceae, Herba Strigae Asiaticae, Fructus Polygoni Orientalis, Rhizoma Cyperi, Radix Triplostegiae Grandiflorae, Herba hypoxis aureae, Rhizomadioscoreae, Radix Kadsurae Coccineae, Fructus Corni, Endoconcha Sepiae, Herba Acalyphae, Rhizoma Cimicifugae, Radix Glycyrrhizae and Pericarpium Granati.
2. Chinese medicine according to claim 1, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Astragali 25-44 weight portion, Caulis Spatholobi 16-28 weight portion, Semen Cuscutae 20-33 weight portion, Fructus Lycii 23-35 weight portion, Radix Dipsaci 10-22 weight portion, Radix Morindae Officinalis 14-25 weight portion, Radix Rehmanniae Preparata 28-40 weight portion, Fructus Rubi 22-34 weight portion, Semen vignae sinensis 14-27 weight portion, Herba Orobanches 11-23 weight portion, Herba Pyrolae 10-22 weight portion, Herba Gonostegiae hirtae 13-25 weight portion, Herba Cynomorii 12-24 weight portion, Herba Orchidis Latifoliae 13-26 weight portion, metapanax of araliaceae 13-25 weight portion, Herba Strigae Asiaticae 14-25 weight portion, Fructus Polygoni Orientalis 13-28 weight portion, Rhizoma Cyperi 25-38 weight portion, Radix Triplostegiae Grandiflorae 15-30 weight portion, Herba hypoxis aureae 8-19 weight portion, Rhizomadioscoreae 19-32 weight portion, Radix Kadsurae Coccineae 8-18 weight portion, Fructus Corni 14-27 weight portion, Endoconcha Sepiae 16-31 weight portion, Herba Acalyphae 9-20 weight portion, Rhizoma Cimicifugae 12-30 weight portion, Radix Glycyrrhizae 14-30 weight portion and Pericarpium Granati 7-17 weight portion.
3. Chinese medicine according to claim 1, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Astragali 27-41 weight portion, Caulis Spatholobi 18-25 weight portion, Semen Cuscutae 21-30 weight portion, Fructus Lycii 25-33 weight portion, Radix Dipsaci 12-20 weight portion, Radix Morindae Officinalis 16-22 weight portion, Radix Rehmanniae Preparata 28-37 weight portion, Fructus Rubi 22-32 weight portion, Semen vignae sinensis 15-24 weight portion, Herba Orobanches 12-21 weight portion, Herba Pyrolae 12-20 weight portion, Herba Gonostegiae hirtae 15-23 weight portion, Herba Cynomorii 14-21 weight portion, Herba Orchidis Latifoliae 15-22 weight portion, metapanax of araliaceae 14-23 weight portion, Herba Strigae Asiaticae 17-23 weight portion, Fructus Polygoni Orientalis 16-26 weight portion, Rhizoma Cyperi 27-35 weight portion, Radix Triplostegiae Grandiflorae 17-26 weight portion, Herba hypoxis aureae 9-16 weight portion, Rhizomadioscoreae 21-30 weight portion, Radix Kadsurae Coccineae 10-16 weight portion, Fructus Corni 14-24 weight portion, Endoconcha Sepiae 17-29 weight portion, Herba Acalyphae 9-16 weight portion, Rhizoma Cimicifugae 12-23 weight portion, Radix Glycyrrhizae 18-27 weight portion and Pericarpium Granati 8-15 weight portion.
4. the Chinese medicine according to any one of claims 1 to 3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: the Radix Astragali 27 weight portion, Caulis Spatholobi 22 weight portion, Semen Cuscutae 24 weight portion, Fructus Lycii 31 weight portion, Radix Dipsaci 12 weight portion, Radix Morindae Officinalis 16 weight portion, Radix Rehmanniae Preparata 37 weight portion, Fructus Rubi 32 weight portion, Semen vignae sinensis 15 weight portion, Herba Orobanches 16 weight portion, Herba Pyrolae 20 weight portion, Herba Gonostegiae hirtae 17 weight portion, Herba Cynomorii 21 weight portion, Herba Orchidis Latifoliae 22 weight portion, metapanax of araliaceae 18 weight portion, Herba Strigae Asiaticae 23 weight portion, Fructus Polygoni Orientalis 16 weight portion, Rhizoma Cyperi 32 weight portion, Radix Triplostegiae Grandiflorae 23 weight portion, Herba hypoxis aureae 11 weight portion, Rhizomadioscoreae 30 weight portion, Radix Kadsurae Coccineae 13 weight portion, Fructus Corni 24 weight portion, Endoconcha Sepiae 28 weight portion, Herba Acalyphae 10 weight portion, Rhizoma Cimicifugae 23 weight portion, Radix Glycyrrhizae 26 weight portion and Pericarpium Granati 15 weight portion.
5. according to the arbitrary described Chinese medicine of claim 1-4, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: the Radix Astragali 41 weight portion, Caulis Spatholobi 25 weight portion, Semen Cuscutae 21 weight portion, Fructus Lycii 33 weight portion, Radix Dipsaci 20 weight portion, Radix Morindae Officinalis 20 weight portion, Radix Rehmanniae Preparata 28 weight portion, Fructus Rubi 22 weight portion, Semen vignae sinensis 24 weight portion, Herba Orobanches 12 weight portion, Herba Pyrolae 12 weight portion, Herba Gonostegiae hirtae 23 weight portion, Herba Cynomorii 14 weight portion, Herba Orchidis Latifoliae 17 weight portion, metapanax of araliaceae 14 weight portion, Herba Strigae Asiaticae 20 weight portion, Fructus Polygoni Orientalis 26 weight portion, Rhizoma Cyperi 27 weight portion, Radix Triplostegiae Grandiflorae 26 weight portion, Herba hypoxis aureae 16 weight portion, Rhizomadioscoreae 21 weight portion, Radix Kadsurae Coccineae 16 weight portion, Fructus Corni 14 weight portion, Endoconcha Sepiae 29 weight portion, Herba Acalyphae 16 weight portion, Rhizoma Cimicifugae 12 weight portion, Radix Glycyrrhizae 18 weight portion and Pericarpium Granati 12 weight portion.
6. according to the arbitrary described Chinese medicine of claim 1-4, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: the Radix Astragali 31 weight portion, Caulis Spatholobi 18 weight portion, Semen Cuscutae 30 weight portion, Fructus Lycii 25 weight portion, Radix Dipsaci 18 weight portion, Radix Morindae Officinalis 22 weight portion, Radix Rehmanniae Preparata 33 weight portion, Fructus Rubi 29 weight portion, Semen vignae sinensis 19 weight portion, Herba Orobanches 21 weight portion, Herba Pyrolae 18 weight portion, Herba Gonostegiae hirtae 15 weight portion, Herba Cynomorii 16 weight portion, Herba Orchidis Latifoliae 15 weight portion, metapanax of araliaceae 23 weight portion, Herba Strigae Asiaticae 17 weight portion, Fructus Polygoni Orientalis 24 weight portion, Rhizoma Cyperi 35 weight portion, Radix Triplostegiae Grandiflorae 17 weight portion, Herba hypoxis aureae 9 weight portion, Rhizomadioscoreae 28 weight portion, Radix Kadsurae Coccineae 10 weight portion, Fructus Corni 20 weight portion, Endoconcha Sepiae 17 weight portion, Herba Acalyphae 9 weight portion, Rhizoma Cimicifugae 22 weight portion, Radix Glycyrrhizae 27 weight portion and Pericarpium Granati 8 weight portion.
7. according to the arbitrary described Chinese medicine of claim 1-6, it is characterized in that, when the dosage form of described Chinese medicine is honey refining pill, its preparation method comprises the following steps:
Step 1: first by ratio mixing described in the Radix Astragali, Caulis Spatholobi, Semen Cuscutae, Fructus Lycii, Radix Dipsaci, Radix Morindae Officinalis, Radix Rehmanniae Preparata, Fructus Rubi, Semen vignae sinensis and Herba Orobanches, distillation crystallization obtains powder;
Step 2: get surplus stock medical material again and mix in described ratio, add relative to 83-94% soak with ethanol 1-2 hour of mixture 2-6 times amount, heating extraction 2 times, each 1-1.5 hour, merge extractive liquid, 124-150 order filters, be the ultrafiltration post ultrafiltration of 4400-98000 again through the molecular weight that dams, when ultrafiltrate is evaporated to 87 DEG C, relative density is the extractum of 1.04, becomes component 1;
Step 3: step 2 Chinese medicine slag is added 4-6 times amount water soaking 1-2.5 hour, extract 1 time, extraction time is 1.5-2 hour, and thickening filtration is extractum shape, is component 2;
Step 4: said components 1 and component 2 two kinds of extractum are condensed into pasty state, add the powder that step 1 obtains, add Mel and be twisted into pill.
8., according to the arbitrary described Chinese medicine of claim 1-6, it is characterized in that, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 ~ 5 times is the ethanol of 85% ~ 90%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 3 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 ~ 3 hours, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.15 ~ 0.3 times of lactose, the starch of 0.2 ~ 0.35 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.025 ~ 0.04 times of magnesium stearate, granulate, tabletting, makes.
9., according to the arbitrary described Chinese medicine of claim 1-6, it is characterized in that, when the dosage form of described Chinese medicine is decoction, its preparation method comprises the following steps:
Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-10 hour;
Step 2: be placed in by purple casserole on fire, after intense fire boils, uses slow fire instead and decocts 30-50 minute slowly, filters, obtains filtrate a, for subsequent use;
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour;
Step 4: be placed in by purple casserole on fire, after intense fire boils, uses slow fire instead and decocts 25-35 minute slowly, filters, obtains filtrate b, mixed by filtrate a and filtrate b.
CN201410669052.8A 2014-11-20 2014-11-20 Traditional Chinese medicine for treating kidney-deficiency uterine prolapse and a preparation method Withdrawn CN104398822A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105250422A (en) * 2015-11-19 2016-01-20 包莉丽 Traditional Chinese medicine for treating prolapse of uterus
CN105434881A (en) * 2015-12-31 2016-03-30 杜成彬 Traditional Chinese medicine for treating kidney-deficiency uterine prolapse

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101057932A (en) * 2007-05-05 2007-10-24 袁爱仙 Medicine decoction for treating hysteroptosis and its preparation method
CN103655845A (en) * 2013-12-04 2014-03-26 陈玉婷 Traditional Chinese medicine composition for treating uterine prolapse

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101057932A (en) * 2007-05-05 2007-10-24 袁爱仙 Medicine decoction for treating hysteroptosis and its preparation method
CN103655845A (en) * 2013-12-04 2014-03-26 陈玉婷 Traditional Chinese medicine composition for treating uterine prolapse

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105250422A (en) * 2015-11-19 2016-01-20 包莉丽 Traditional Chinese medicine for treating prolapse of uterus
CN105434881A (en) * 2015-12-31 2016-03-30 杜成彬 Traditional Chinese medicine for treating kidney-deficiency uterine prolapse

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