CN107412255A - Skin barrier remediation composition and preparation - Google Patents
Skin barrier remediation composition and preparation Download PDFInfo
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- CN107412255A CN107412255A CN201710685660.1A CN201710685660A CN107412255A CN 107412255 A CN107412255 A CN 107412255A CN 201710685660 A CN201710685660 A CN 201710685660A CN 107412255 A CN107412255 A CN 107412255A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/78—Polymers containing oxygen of acrylic acid or derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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Abstract
The invention discloses a kind of skin barrier remediation composition and preparation, said composition is made up of following raw materials：Trehalose 0.05% 20%, polyacrylic acid 0.1% 20%, glycerine 1 50%, surplus is cocoa butter or vaseline.It is demonstrated experimentally that the skin barrier remediation composition of the present invention, it is demonstrated experimentally that formulation made of the skin barrier remediation composition of the present invention：Gel, aqua, ointment or cream, by to skin moisture-keeping, supplementing oil content, can effectively remissive treatment via laser beautifying, tartaric acid change redness after the beauty means such as skin caused by skin, heat bitterly, take off the symptoms such as skin, itch, assimilation effect is good, can also improve sensitive skin.Preparation method is simple, with short production cycle, and prescription is simplified, and cost is low.
Description
Technical field
The invention belongs to biomedicine technical field, is specifically related to a kind of skin barrier remediation composition and containing this
The preparation of composition.
Background technology
Two during the last ten years, and with deepening continuously for China's reform and opening-up, medical shaping and beauty industry is a dark horse, and development is fast
Speed, market is vigorous not to wane.21 century beauty is already required into the life of young women.2014, beauty mechanism of China
The overall market capacity has reached 553,000,000,000 yuan, wherein medical shaping and beauty market accounts for 3.8% share, i.e. medical shaping in 2014
Beauty industry whole nation total quantity consumed breaks through 21,000,000,000 yuan.Recent years, Chinese people are more and more stronger to beautiful and fashion pursuit
Strong, China's beauty industry will also persistently keep rapid growth situation.
The cardinal principle of laser beautifying employ it is beneficial to human body, through ability compared with it is strong, tissue absorptivity is high
Light-wave band, the stimulation using weak laser to biological tissue, facial meridian point is effectively stimulated, accelerates blood circulation,
Improve the supply condition of skin, increase skin tissue's nutrition, promote the anabolism and tissue repair of human body, so as to improve face
The colour of skin is dark and gloomy, pigmentation, cutis laxa, wrinkle, pouch are sagging, livid ring around eye, the thick, pachylosis of pore etc., makes facial skin
The ruddy gloss of skin, elasticity strengthen, the aging of delaying skin, play the effect of skin maintenance.But it can go out after laser beautifying sometimes
Existing skin barrier damaged phenomenon, and then there are the symptoms such as red, swollen, hot, pain, annoying these people to like to be beautiful.
The content of the invention
The purpose of the present invention is overcome the deficiencies in the prior art, there is provided skin barrier remediation composition.
Second object of the present invention is to provide a kind of preparation of remediation composition containing skin barrier.
Technical scheme is summarized as follows：
Skin barrier remediation composition, it is made up by weight percentage of following raw materials：Trehalose 0.05%-20%, poly- third
Olefin(e) acid sodium 0.1%-20%, glycerine 1%-50%, surplus is cocoa butter or vaseline.
Preferably, the trehalose is 0.5%-5%, Sodium Polyacrylate 0.5%-5%, glycerine 3%-20%, surplus
For cocoa butter or vaseline.
Include the preparation of above-mentioned skin barrier remediation composition, be by weight percentage by 5%~23% skin barrier
Remediation composition and surplus are made up of pharmaceutic adjuvant.
The formulation of preparation is preferably gel, aqua, ointment or cream.
It is demonstrated experimentally that formulation made of the skin barrier remediation composition of the present invention：Gel, aqua, ointment or breast
Paste, by skin moisture-keeping, supplementing oil content, effectively can change the beautifying hands such as skin via laser beautifying, tartaric acid by remissive treatment
Redness, heat pain after section caused by skin, the symptoms such as skin, itch are taken off, assimilation effect is good, can also improve sensitive skin.Preparation method
Simply, with short production cycle, prescription is simplified, and cost is low.
Embodiment
With reference to specific embodiment, the present invention is further illustrated.
Embodiment 1
Skin barrier remediation composition, by weight percentage by 20% trehalose, 20% Sodium Polyacrylate, 50% glycerine and
10% cocoa butter forms.
Embodiment 2
Skin barrier remediation composition, by weight percentage by 0.05% trehalose, 0.1% Sodium Polyacrylate, 1% glycerine
Formed with 98.85 vaseline.
Embodiment 3
Skin barrier remediation composition, by weight percentage by 0.5% trehalose, 5% Sodium Polyacrylate, 3% glycerine and
91.5% cocoa butter forms.
Embodiment 4
Skin barrier remediation composition, by weight percentage by 5% trehalose, 0.5% Sodium Polyacrylate, 20% glycerine and
74.5% vaseline forms.
Embodiment 5
The gel of skin barrier remediation composition is included, is made of following methods：
(1) weigh the skin barrier remediation composition of 5g embodiments 1,2g niacinamide, 1g carbomers, 1g triethanolamines and
91g water；
(2) skin barrier remediation composition is heated to 80, stirred, obtain mixture 1, separately take a container, by nicotinoyl
Amine, carbomer, triethanolamine and water are heated to 80 DEG C, insulated and stirred, stir, and obtain mixture 2, then mixture 1 is added
Into mixture 2, insulated and stirred 35min, to uniform, 30 DEG C are cooled to, you can.
Embodiment 6
The gel of skin barrier remediation composition is included, is made of following methods：
(1) the skin barrier remediation composition of 20g embodiments 2,2g niacinamide, 0.8g carbomers, the ethanol of 0.8g tri- are weighed
Amine and 76.4g water；
(2) skin barrier remediation composition is heated to 80, stirred, obtain mixture 1, separately take a container, by nicotinoyl
Amine, carbomer, triethanolamine and water are heated to 80 DEG C, insulated and stirred, stir, and obtain mixture 2, then mixture 1 is added
Into mixture 2, insulated and stirred 35min, to uniform, 30 DEG C are cooled to, you can.
Embodiment 7
The gel of skin barrier remediation composition is included, is made of following methods：
(1) the skin barrier remediation composition of 23g embodiments 3,2g niacinamide, 0.5g carbomers, the ethanol of 0.5g tri- are weighed
Amine and 74g water；
(2) skin barrier remediation composition is heated to 80, stirred, obtain mixture 1, separately take a container, by nicotinoyl
Amine, carbomer, triethanolamine and water are heated to 80 DEG C, insulated and stirred, stir, and obtain mixture 2, then mixture 1 is added
Into mixture 2, insulated and stirred 35min, to uniform, 30 DEG C are cooled to, you can.
Embodiment 8
The gel of skin barrier remediation composition is included, is made of following methods：
(1) the skin barrier remediation composition of 6.5g embodiments 4,2g niacinamide, 0.5g carbomers, 1g triethanolamines are weighed
With 90g water；
(2) skin barrier remediation composition is heated to 80, stirred, obtain mixture 1, separately take a container, by nicotinoyl
Amine, carbomer, triethanolamine and water are heated to 80 DEG C, insulated and stirred, stir, and obtain mixture 2, then mixture 1 is added
Into mixture 2, insulated and stirred 35min, to uniform, 30 DEG C are cooled to, you can.
Embodiment 9
The cream of skin barrier remediation composition is included, is made of following methods：
(1) the skin barrier remediation composition of 5g embodiments 1,4g mixed fatty glycerides and 91g water are weighed；
(2) skin barrier remediation composition is stirred, heating water bath is incubated 25min, obtains mixture 1 to 80 DEG C, will
Mixed fatty glycerides and water are well mixed, and are heated to 80 DEG C, obtain mixture 2, add mixture 1 under processing condition
Into mixture 2, homogeneous 5 minutes, insulated and stirred 25min is cooled to 30, produces.
Embodiment 10
The ointment of skin barrier remediation composition is included, is made of following methods：
(1) the skin barrier remediation composition of 20g embodiments 1,5g lanolin, 5g corn oils and 70g water are weighed；
(2) skin barrier remediation composition and lanolin, corn oil are stirred, heating water bath is to 80 DEG C, insulation
25min, mixture is obtained, under heat-retaining condition, add water, stir, be incubated 30 minutes, be cooled to 40 DEG C, produce.
Embodiment 11
The aqua of skin barrier remediation composition is included, is made of following methods：
(1) the skin barrier remediation composition of 6.5g embodiments 1,15g maltose, 15g niacinamide and 63.5g water are weighed；
(2) by skin barrier remediation composition and maltose, niacinamide and water, stirring in water bath is heated to 80 DEG C, insulation
25min, 40 DEG C are cooled to, is produced.
Following examples control group is：
Compare 1 group：Embodiment 11 in Chinese patent 201410588132.0.
According to a kind of formula (wound repair hydrocolloid, by quality by trehalose 5%, sodium carboxymethylcellulose of embodiment 3
6%th, 1,3 butanediols 20% and purified water 69% form.), trehalose, sodium carboxymethylcellulose, NMF and purified water are added
Heat makes it well mixed during heating to 85 DEG C with 20rpm speed stirring；It is continuously heating to open vacuum at 90 DEG C, vacuum-
0.05-0Mpa, homogeneous rotating speed 4000rpm, homogeneous 8 minutes, 40 minutes are incubated at 70 DEG C after homogeneous, then are cooled to room temperature, obtained
Hydrocolloid intermediate, it is filling after intermediate detection is qualified, canned hydrocolloid is subjected to sterilization treatment, finished product detection, bag
Dress.
Compare 2 groups：Embodiment 8 in Chinese patent 201610214919.X
(1) by embodiment 3, (a kind of sebum film maintenance composition, is made up of following raw materials by mass percentage：Hyaluronic acid
Sodium 0.3%, trehalose 2%, (glycerine and butanediol mass ratio are 2 to NMF:3) 10%, grease (Butyrospermum parkii fruit fat and breast wood
The mass ratio of fruit oil is 1:1) 3%, Sodium Polyacrylate 0.8% and sodium-chloride water solution 83.9%, (the quality of sodium-chloride water solution
0.9%) concentration is.
Compare 3 groups：The compound method of the prescription of embodiment 8 and embodiment 14 in Chinese patent 201410588382.4.
Prescription is：
Comprising a kind of paste of skin barrier remediation composition, by weight percentage by a kind of (the skin screen of 25% embodiment 1
Hinder remediation composition, be made up of by weight percentage 10% trehalose and 90% sodium carboxymethylcellulose.) prepare a kind of skin
Skin barrier remediation composition, 25% glycerine, 25% propane diols and 25%PEG 400 are made.
Preparation method：
By pharmaceutically acceptable auxiliary material heating water bath to 80 DEG C, make it well mixed, then add composition skin barrier and repair
The trehalose and sodium carboxymethylcellulose of compound composition, stirring make its suspended dispersed.40 DEG C are cooled to, is filled and is encapsulated in closed appearance
Sterilizing chamber is sent into device and carries out 60Coradiation sterilizing, is provided according to medicine after completing irradiation sterilization, that is, is made and includes a kind of skin
The paste of barrier remediation composition.
Embodiment 12
Skin surface moisture after the invention is used via skinanalysis apparatus measurement.
The people of volunteer 150 is chosen, is divided into 15 groups, every group of 10 people, a diameter of 3cm circle is drawn on arm inside skin,
Each group embodiment product, reference product 0.05ml are smeared, basic number is tested using German CK skinanalysis apparatus MC760 moisturizings probe
Value (using preceding humidity), 4 hours humidity of skin (using rear humidity) data such as following tables.
Table 1, compared using front and rear humidity of skin
| Group | Use preceding humidity | Use rear humidity |
| 5 groups of embodiment | 32.17±3.74 | 76.74±3.85* |
| 6 groups of embodiment | 32.65±4.21 | 77.48±4.27* |
| 7 groups of embodiment | 33.24±3.19 | 76.87±3.85* |
| 8 groups of embodiment | 32.95±4.69 | 75.22±5.21* |
| 9 groups of embodiment | 31.69±4.87 | 75.62±4.68* |
| 10 groups of embodiment | 32.58±5.19 | 76.16±5.19* |
| 11 groups of embodiment | 33.14±5.09 | 76.28±4.27* |
| Trehalose | 32.05±4.19 | 39.16±4.56 |
| Sodium Polyacrylate | 33.96±5.39 | 35.31±5.69 |
| Glycerine | 31.91±5.12 | 40.61±4.39 |
| Cocoa butter | 32.50±4.62 | 37.49±5.04 |
| Vaseline | 35.06±5.71 | 37.05±4.19 |
| Compare 1 group | 32.84±3.25 | 49.53±4.25 |
| Compare 2 groups | 31.54±3.59 | 70.59±5.24 |
| Compare 3 groups | 32.92±4.26 | 48.57±5.07 |
* with compareing 2 groups than P ＜ 0.05
Embodiment 13
160 Balb/c male mices are taken, back depilation, are cleaned out with physiological saline.1% yellow Jackets of mouse
After intraperitoneal injection of anesthesia, dorsal injection epirubicin (2mg/ml).The mouse for forming the exedens surface of a wound is randomly divided into 16 groups, sky
White control group does not make any processing, and each group is first cleaned a wound, with sterile after smearing before corresponding experiment product is smeared with physiological saline
Gauze is fixed and bound up a wound, and every dressing in 2 days 1 time, observes wound healing situation.
Do not heal Wound healing rate=(original surface of a wound area-surface of a wound area)/original surface of a wound area.For the original surface of a wound and
Do not heal the method that the surface of a wound draws surface of a wound shape with transparent graph paper, with image J software processing pictures, calculates wound healing
Rate.
The surface of a wound situation table of table 2
* with compareing 2 groups than P ＜ 0.05
Embodiment 14
Clinical test
It is chosen at that hospital changes skin via tartaric acid, crystallite grinding, laser anti-acne, laser are dispelled skin caused by the beauty means such as melanin
Red and swollen heat pain of skin etc..Totally 400, wherein male 74, women 326, age 18-52 year, average age (28.6 ± 7.1)
Year.It is divided into 10 groups.
Treatment method：Product of the present invention is given by treatment group；Control group is divided into 3 groups and uses corresponding product respectively.To prescription
Method is：After cleaning cutaneous lesion, use, the 1st day to the 10th day, daily using 1 time, the 10th day to 20 days, every other day using 1 time,
Each coating time is 20 minutes.
Evaluation index：With reference to《New Chinese medicine guideline of clinical investigations》, carry out clinical evaluation.Carried out by same observer
The observation of skin severity scale and adverse events.
Clinical performance symptom and sign is evaluated and grade scale
Symptom score is carried out with reference to the sensitive dermatitis standard of face:Erythema, oedema, ooze out, shouting pain, pigmentation respectively by
Without, it is light, in, restatement be 0-3 points.
Specially：
Erythema：Erythema color it is scarlet or it is dark red meter 3 points；Obvious erythema meter 2 divides；Light red spot meter 1 divides；Without color change meter 0
Point.
Oedema：3 points of corium oedema infiltration meter occurs for extensive region；Many places occur clear and definite corium oedema meter 2 and divided；Partial zones
Domain corium oedema is not easy to be touched 1 point of meter；Divide without oedema meter 0.
Ooze out：Ooze out it is obvious that the scope matter of fundamental importance 3 is divided；Ooze out more apparent, scope is divided compared with subtotal 2；Point-like is seen after examining
Ooze out 1 point of meter；0 point is counted without oozing out.
Shouting pain：Continue tingling sensation, 3 points of meter can not be endured；Continue or be interrupted tingling sensation, 2 points of meter can be endured；Once in a while, slightly
Shouting pain meter 1 divides；Divide without tingling sensation meter 0.
Pigmentation：Pigmentation is it is obvious that scope is divided compared with the matter of fundamental importance 3；Pigmentation is more apparent, and scope is divided compared with subtotal 2；It is young
Visible slight pigmentation meter 1 divides after thin observation；Calm 0 point of the meter of non-pigment.
Curative effect evaluation standard：According to recovery from illness, effective, effective, invalid four standards.
Therapeutic index=[being integrated before (being integrated before treatment after integration-treatment) ÷ treatments] × 100%
Recovery from illness:Therapeutic index >=95%；It is effective:70%≤therapeutic index ＜ 95%；Effectively:30%≤therapeutic index ＜
70%；It is invalid:Therapeutic index ＜ 30%.Total effective rate=(recovery from illness number of cases+effective number of cases+effective number of cases) ÷ total number of cases ×
100%.
Safety evaluatio：The appearance that has no adverse reaction has been examined during Clinical practice, has conscientiously been recorded, and has followed the trail of sight
Examine, if finding, patient has uncomfortable reaction, should interrupt treatment immediately, and actively take symptomatic treatment.To there is clinical meaning
Adverse events, need follow-up to symptom to disappear, and record.
Table 3, each group therapeutic evaluation
| Group | Cure | It is effective | Effectively | It is invalid | It is efficient |
| 5 groups of embodiment | 33 | 2 | 2 | 3 | 92.5% |
| 6 groups of embodiment | 33 | 2 | 3 | 2 | 95% |
| 7 groups of embodiment | 34 | 1 | 3 | 2 | 95% |
| 8 groups of embodiment | 36 | 1 | 0 | 3 | 92.5% |
| 9 groups of embodiment | 32 | 2 | 3 | 3 | 92.5% |
| 10 groups of embodiment | 34 | 1 | 2 | 3 | 92.5% |
| 11 groups of embodiment | 34 | 1 | 3 | 2 | 95% |
| Compare 1 group | 15 | 5 | 12 | 8 | 80% |
| Compare 2 groups | 16 | 13 | 6 | 5 | 87.5% |
| Compare 3 groups | 12 | 7 | 9 | 12 | 70% |
Skin barrier function detects：Using German CK companies Multi probe skin measurement system MPA9, CM825 (moisture measurement
Probe) and TM300 (water loss test probe) detection water content of stratum corneum and transepidermal water loss amount (TEWL).In constant temperature and humidity
Under the conditions of be measured, 20-25 DEG C of room temperature, relative humidity 40%-60%, testee cleans skin to be measured simultaneously before detection
30min enters quiet to be measured in test environment in advance, detects the non-cutaneous lesion of cheek respectively.
Table 4, skin transepidermal water loss amount (TEWL) and water content of stratum corneum compare
| Group | Transepidermal water loss amount | Water content of stratum corneum |
| 5 groups of embodiment | 6.43±3.62 | 38.96±3.47* |
| 6 groups of embodiment | 7.17±2.72 | 40.37±3.08* |
| 7 groups of embodiment | 8.27±3.58 | 39.47±4.01* |
| 8 groups of embodiment | 7.34±2.57 | 40.28±3.80* |
| 9 groups of embodiment | 7.48±3.69 | 40.65±4.22* |
| 10 groups of embodiment | 8.61±2.76 | 41.28±3.96* |
| 11 groups of embodiment | 6.52±3.19 | 42.39±4.17* |
| Compare 1 group | 12.74±3.55 | 31.94±4.28 |
| Compare 2 groups | 12.57±4.29 | 32.36±3.92 |
| Compare 3 groups | 13.07±3.94 | 32.58±5.03 |
*With compareing 2 groups than P ＜ 0.05
Comparison (the ug/cm of table 5, pretherapy and post-treatment skin oil and fat amount2)
| Group | Before treatment | After treatment |
| 5 groups of embodiment | 82.05±6.12 | 115.37±5.69* |
| 6 groups of embodiment | 82.04±5.87 | 114.82±6.85* |
| 7 groups of embodiment | 81.76±6.31 | 116.29±5.91* |
| 8 groups of embodiment | 82.74±5.07 | 114.21±5.62* |
| 9 groups of embodiment | 81.36±6.29 | 116.28±6.47* |
| 10 groups of embodiment | 82.18±5.17 | 115.39±5.04* |
| 11 groups of embodiment | 82.64±4.62 | 116.51±6.39* |
| Compare 1 group | 82.36±4.91 | 95.62±6.37 |
| Compare 2 groups | 81.25±5.36 | 95.83±6.25 |
| Compare 3 groups | 80.86±5.34 | 95.62±6.60 |
*With compareing 2 groups than P ＜ 0.05.
Claims (4)
1. skin barrier remediation composition, it is characterized in that being made up of by weight percentage following raw materials：Trehalose 0.05%-
20%, Sodium Polyacrylate 0.1%-20%, glycerine 1%-50%, surplus are cocoa butter or vaseline.
2. skin barrier remediation composition according to claim 1, it is characterized in that the trehalose is 0.5%-5%, gather
PAA 0.5%-5%, glycerine 3%-20%, surplus are cocoa butter or vaseline.
3. the preparation of the skin barrier remediation composition comprising claim 1 or 2, it is characterized in that by weight percentage by 5%~
23% skin barrier remediation composition and surplus is made up of pharmaceutic adjuvant.
4. the preparation of skin barrier remediation composition according to claim 3, it is characterized in that the formulation of described preparation is
Gel, aqua, ointment or cream.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710685660.1A CN107412255A (en) | 2017-08-11 | 2017-08-11 | Skin barrier remediation composition and preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710685660.1A CN107412255A (en) | 2017-08-11 | 2017-08-11 | Skin barrier remediation composition and preparation |
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ID=60437882
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112007059A (en) * | 2020-09-04 | 2020-12-01 | 郝红 | Medical skin repairing gel, preparation method and application thereof in preparation of medicine for treating dermatitis |
| CN114129474A (en) * | 2021-10-11 | 2022-03-04 | 西安惠普生物科技有限公司 | Sterile adhesive film and preparation method thereof |
| CN115337219A (en) * | 2022-09-09 | 2022-11-15 | 陕西佰傲再生医学有限公司 | Skin repair composition and preparation method thereof |
| CN117414465A (en) * | 2023-11-03 | 2024-01-19 | 珠海市雅莎医疗器械有限公司 | Medical trehalose gel with repairing effect and preparation method thereof |
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| CN105726366A (en) * | 2016-04-07 | 2016-07-06 | 天津嘉氏堂医美科技有限公司 | Skin lipid membrane repairing composition |
| CN106511220A (en) * | 2016-12-30 | 2017-03-22 | 广东国方医药科技有限公司 | Dendrobium officinale moisturizing and repair sleeping mask and preparation method thereof |
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| CN105726366A (en) * | 2016-04-07 | 2016-07-06 | 天津嘉氏堂医美科技有限公司 | Skin lipid membrane repairing composition |
| CN106511220A (en) * | 2016-12-30 | 2017-03-22 | 广东国方医药科技有限公司 | Dendrobium officinale moisturizing and repair sleeping mask and preparation method thereof |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112007059A (en) * | 2020-09-04 | 2020-12-01 | 郝红 | Medical skin repairing gel, preparation method and application thereof in preparation of medicine for treating dermatitis |
| CN112007059B (en) * | 2020-09-04 | 2023-01-17 | 郝红 | Medical skin repairing gel, preparation method and application thereof in preparation of medicine for treating dermatitis |
| CN114129474A (en) * | 2021-10-11 | 2022-03-04 | 西安惠普生物科技有限公司 | Sterile adhesive film and preparation method thereof |
| CN114129474B (en) * | 2021-10-11 | 2023-06-30 | 西安惠普生物科技有限公司 | Sterile film and preparation method thereof |
| CN115337219A (en) * | 2022-09-09 | 2022-11-15 | 陕西佰傲再生医学有限公司 | Skin repair composition and preparation method thereof |
| CN117414465A (en) * | 2023-11-03 | 2024-01-19 | 珠海市雅莎医疗器械有限公司 | Medical trehalose gel with repairing effect and preparation method thereof |
| CN117414465B (en) * | 2023-11-03 | 2024-04-19 | 珠海市雅莎医疗器械有限公司 | Medical trehalose gel with repairing effect and preparation method thereof |
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Application publication date: 20171201 |