CN110115692A - A kind of skin care compositions and its application containing glabridin and Ectoin - Google Patents
A kind of skin care compositions and its application containing glabridin and Ectoin Download PDFInfo
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- CN110115692A CN110115692A CN201910455035.7A CN201910455035A CN110115692A CN 110115692 A CN110115692 A CN 110115692A CN 201910455035 A CN201910455035 A CN 201910455035A CN 110115692 A CN110115692 A CN 110115692A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61Q19/00—Preparations for care of the skin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The invention discloses a kind of skin care compositions containing glabridin and Ectoin and its application, effective component includes glabridin and Ectoin.Present composition composition is simple, and two kinds of effective active compositions are simple and easy to get, can be used for the color spots such as the obscure colour of skin, sunburn and chloasma, especially obvious to chloasma effect, shortens the nti-freckle period；After the skin care compositions is further processed, the various types of cosmetics with freckle effect or external preparation for skin drug can be made.
Description
Technical field
The present invention relates to a kind of skin care compositions containing glabridin and Ectoin, further relates to the skin care compositions and is dispelling
Application in the cosmetics of spot cosmetics especially eliminate chloasma, belongs to cosmetic technical field.
Background technique
Chloasma is a kind of acquired symmetrical dermatoses of facial pigmentation metabolic disorder, in light brown or auburn pigment
Spot is distributed in generally symmetrically around a near its circumference, forehead, cheekbone cheek, nose side and lip, and clear border does not protrude skin
Skin, no scurf fall off, and sunlight irradiation can deepen its pigment, and most of patients is without any subjective symptoms.The pathogenesis pole of chloasma
It is complicated, and before the onset without local inflammation and trauma history, histological characteristic is mainly melanin and melanosome increase in epidermis,
Melanocyte activity enhancing, but real the reason of changing melanocyte function, is unclear.Modern medicine thinks chloasma
With ultraviolet light irradiation, endocrine disorder, heredity, oxygen radical, D&C, oral contraceptive, local Tiny ecosystem, body
The factors such as systemic lesion, mood swing have relationship.Traditional Chinese Medicine experts think internal organs discord, disorder of emotion, disorder of qi and blood, Nv Zichong
Appointing functional disturbance is to generate the basic reason of chloasma.
There are many doctor's beauty and the product of cosmetic field whitening spot-removing or the composition for the whitening spot-removing being related at present, but this
A little products or composition primarily directed to the formation of melanin, transfer or accelerate the metabolism of skin epidermis to dispel to play whitening
It is the effect of spot, this in the obstinate color spot of basal layer formation almost without effect for chloasma, even it will appear sometimes
Whitening product has used skin luminance raising more and has allowed the more obvious phenomenon of chloasma.
Chloasma seriously affects beauty, and is difficult to dispel, and very big puzzlement is brought to people seeking beauty.It is controlled at present using Chinese medicine
The comparison for treating chloasma is more, and in the prior art, ZL201410326581.8 discloses a kind of Chinese traditional medicine composition for functions of removing chloasma
In conjunction with the preparation process of formulation, it is true to reach highly-safe, curative effect using integration of drinking and medicinal herbs Chinese herbal medicine as raw material for object and preparation method thereof
The purpose cut and had no toxic side effect, but the product composition is more；ZL200610117403.X discloses a kind of medicine for treating chloasma
Object, health care product and cosmetic composition, active constituent are the extract of 3 kinds of rhizoma atractylodis, the seed of jog's tears and Cortex Phellodendri traditional Chinese medicine ingredients, the invention
Composition needs to extract in advance, using unknowable in terms of the cosmetics of importing type；ZL201510013571.3 is disclosed
A kind of paste and preparation method thereof removing chloasma, which modulated by mixing thick paste and albolene, described mixed
Conjunction thick paste prepares raw materials used by weight by 18~23 parts of roots of Dahurain angelica, 15~20 parts of ramulus cinnamomi, 22~27 parts of motherworts, 12~17
Part fructus lycii, 5~10 parts of spina gleditsiae, 18~23 parts of gypsum, 12~17 parts of root of Twelve stamen Melastoma, 16~21 parts of father-in-law's waves, 10~15 parts of water phoenix
Celestial being, 23~28 portions of peppermints, 35~40 parts of Paper mulberry Fruits, 28~33 portions of American Ginsengs, 31~36 parts of rhizoma polygonatis, 27~32 portions of jujubes, 29~
The composition such as 34 portions of Asian puccoons, 12~17 parts of great burdock achenes, the invention are made up using ten several traditional Chinese medicine ingredients of certain preparation method
Thick paste, then paste is made with albolene, it is impossible to be used in daily skin care, and complicated component；Application No. is
201610107376.1 patent discloses a kind of effective with the composition and application, the composition for inhibiting tyrosinase effect
Ingredient is glabridin and resveratrol, for treating chloasma, acne healing, freckle, senile plaque and after-sun recovery and antioxygen
Change, the invention treats chloasma from inhibiting tyrosinase activity angle merely, without the function of actual verification treatment chloasma
Effect.
It can thus be seen that in eliminate chloasma, there are effects is unobvious, the time is all for existing whitening spot-removing class product
The deficiencies of phase is long and ingredient is more.Therefore, it needs to develop a kind of clear, non-stimulated, the simple eliminate chloasma of composition the production of curative effect
Product.
Summary of the invention
For deficiency existing for eliminate chloasma product now, the present invention provides one kind to contain glabridin and Ectoin
Skin care compositions, verified, glabridin and Ectoin can effectively reduce melanin over-deposit in skin, eliminate color
Spot has obvious synergistic function in eliminate chloasma, sunburn and the color spots such as the colour of skin is obscure, especially dispels to chloasma
Except significant effect.
The present invention also provides the skin care compositions containing glabridin and Ectoin to prepare outside cosmetics or skin
With the application in drug, the especially application in the cosmetics of eliminate chloasma or external preparation for skin drug.
The present invention provides a kind of skin care compositions, the effective component of the skin care compositions includes glabridin and Yi Ke more
Cause.Glabridin can go deep into inside skin and keep high activity, whitening and high-efficiency antioxidant, effectively inhibit melanin production process
In a variety of enzymes activity, especially inhibit tyrosinase activity, while also having and prevent pachylosis, anti-inflammatory, anti-oxidant and anti-
The effect of bacterium.Ectoin (tetrahydro methylpyrimidine carboxylic acid, Ectoin) derives from high Halophiles (Halomonas Elongata),
Therefore Ectoin is also called " Facultative Halophiles extract liquor ", it can fetter surrounding water molecules formed complex, be wrapped in cell, enzyme,
Around protein and other organic molecules, the protective shell with protection, nourishing and stabilization is formed, stimulating factor not energy loss is made
Evil cell, so that cellular damage is prevented, especially under the poor environments stimulation such as high temperature, with high salt, freezing, dry, radiation
Cell and large biological molecule have preferable effect.
Further, in above-mentioned skin care compositions, effective component can be only glabridin and Ectoin, can also be
Contain other to the effective effective component such as skin moisture-keeping, whitening, anti-oxidant, nti-freckle outside glabridin and Ectoin.
Further, in above-mentioned skin care compositions, when the mass ratio of glabridin and Ectoin is 1:1-25, performance
Good synergistic effect out has chloasma, sunburn and the color spots such as the colour of skin is obscure and dispels effect well, especially to chloasma
Significant effect is dispelled, when the mass ratio of glabridin and Ectoin is 1:3-5, the synergistic function of the two is more preferably.
It further, further include organic solvent, the work of organic solvent other than effective component in above-mentioned skin care compositions
With being premixed to 2 kinds of effective components, to achieve the purpose that 2 kinds of ingredients can be directly added into aqua system.It is described to have
Solvent can it is highly-safe, small to skin irritation for glycerol, butanediol, pentanediol, dipropylene glycol or propylene glycol etc., can
The sufficiently organic solvent of dissolution glabridin and Ectoin, the considerations of for reasons such as cost considerations, preferably glycerol or fourth
Glycol.Glabridin and Ectoin can be dissolved well, be mixed by organic solvent, it is preferred that glabridin and Yi Ke are more
The gross mass of cause and the mass ratio of organic solvent are 1:10-20.
Further, the present invention also provides the above-mentioned skin care compositions containing glabridin and Ectoin in preparationization
Application in cosmetic or external preparation for skin drug, can be used as the effective component of cosmetics or external preparation for skin drug, individually or
Person is used in mixed way with other compositions.The cosmetics are preferably cosmetics, more preferably the cosmetics of eliminate chloasma.Institute
State the external preparation for skin drug that external preparation for skin drug is preferably nti-freckle, more preferably the external preparation for skin drug of eliminate chloasma.
Further, further include in addition to the skincare composition beyond the region of objective existence containing glabridin and Ectoin in above-mentioned cosmetics
Matrix components necessary to cosmetics are made, the matrix components include but is not limited to solvent, emulsifier, preservative etc..
Further, the cosmetics include toner, essence, cream, frost, facial mask, import liquid, color make-up etc. different class
Type.According to the different type of cosmetics, required matrix components are also different.
Further, the present invention also provides a kind of cosmetics, the cosmetic composition include it is above-mentioned containing glabridin and
The skin care compositions of Ectoin.The cosmetics are cosmetics, the preferably cosmetics of eliminate chloasma.The makeup
Product can be toner, essence, cream, frost, facial mask, import the types such as liquid, color make-up.
It further, further include matrix components necessary to cosmetics in the cosmetics, the matrix components include molten
Agent, emulsifier, preservative etc..
Further, content of the glabridin in cosmetics be 0.01-1wt%, preferably 0.05-0.5wt%,
More preferably 0.4-0.5wt%, content of the Ectoin in cosmetics are 0.1-3wt%, preferably 0.5-
2.5wt%, more preferably 1.5-2wt%.
Further, content of the skin care compositions containing glabridin and Ectoin in cosmetics is 10.11-
33wt%.
Further, the present invention also provides a kind of external preparation for skin drug, the drug ingredient includes above-mentioned Radix Glycyrrhizae containing light
Fixed and Ectoin skin care compositions.The external preparation for skin drug is nti-freckle topical drug, and preferably eliminate chloasma is outer
Use drug.
There is the skin care group containing glabridin and Ectoin for significantly dispelling effect the present invention provides a kind of pair of chloasma
Object is closed, the composition composition is simple, and two kinds of effective active compositions are simple and easy to get, can be used for the obscure colour of skin, sunburn and chloasma etc.
Color spot, it is especially obvious to chloasma effect, shorten the nti-freckle period；It, can be with by the skin care compositions by being further processed
The various types of cosmetics with freckle effect or external preparation for skin drug is made.Meanwhile skin care compositions has been first dissolved in
The problems in aqua can not be directly used in by solving glabridin and Ectoin in solvent.
Specific embodiment
Technical solution and advantage in order to better illustrate the present invention, below in conjunction with specific embodiment to the present invention make into
One step explanation.The unspecified technological parameter of the present invention, raw material etc. are carried out according to conventional technical means in the art.
In following embodiments, unless otherwise instructed, each Ingredient Amount is parts by weight.
In following embodiments, glabridin and Ectoin can be commercially available from market, in glabridin raw material
The content of glabridin is 95-98wt%.
Embodiment 1
Skin care compositions of the present invention is composed of the following components in parts by weight: 0.4 part of glabridin, 2 parts of Ectoin, organic
15 parts of solvent butanediol.
The skin care compositions the preparation method comprises the following steps: glabridin and Ectoin are added in organic solvent, stirring and dissolving
To clear, skin care compositions is obtained.
Embodiment 2
Skin care compositions of the present invention is composed of the following components in parts by weight: 0.5 part of glabridin, 1.5 parts of Ectoin, being had
20 parts of solvent butanediol.
The preparation method is the same as that of Example 1.
Embodiment 3
Skin care compositions of the present invention is composed of the following components in parts by weight: 0.05 part of glabridin, 0.5 part of Ectoin,
10 parts of organic solvent glycerol.
The preparation method is the same as that of Example 1.
Embodiment 4
Skin care compositions of the present invention is composed of the following components in parts by weight: 0.1 part of glabridin, 2.5 parts of Ectoin, being had
15 parts of solvent glycerol.
The preparation method is the same as that of Example 1.
Embodiment 5
Skin care compositions of the present invention is composed of the following components in parts by weight: 0.2 part of glabridin, 1 part of Ectoin, organic
20 parts of solvent glycerin.
The preparation method is the same as that of Example 1.
Comparative example 1
Skin care compositions is composed of the following components in parts by weight: 0.4 part of glabridin, 0 part of Ectoin；Skin care mixture
In organic solvent be 20 parts of butanediol.
The preparation method is the same as that of Example 1.
Comparative example 2
Skin care compositions of the present invention is composed of the following components in parts by weight: 0 part of glabridin, 2 parts of Ectoin, and You Jirong
15 parts of agent butanediol.
The preparation method is the same as that of Example 1.
Comparative example 3
Skin care compositions is composed of the following components in parts by weight: 1.5 parts of glabridin, 2 parts of Ectoin, and organic solvent fourth
20 parts of glycol.
The preparation method is the same as that of Example 1.
Comparative example 4
Skin care compositions is composed of the following components in parts by weight: 0.4 part of glabridin, 5 parts of Ectoin, organic solvent is sweet
20 parts of oil.
The preparation method is the same as that of Example 1.
Comparative example 5
Skin care compositions is composed of the following components in parts by weight: 2 parts of niacinamide, 2 parts of Ectoin, and organic solvent glycerol 15
Part.
The preparation method is the same as that of Example 1.
Comparative example 6
Skin care compositions is composed of the following components in parts by weight: 0.4 part of glabridin, 1 part of resveratrol, and organic solvent fourth
15 parts of glycol.
The preparation method is the same as that of Example 1.
Application examples
The above embodiment of the present invention and the skin care compositions of comparative example preparation can be used for cosmetics, can be used for skin
Topical drug.The type of cosmetics includes but is not limited to toner, essence, cream, frost, facial mask, importing liquid, color make-up etc..It is preparing
When, it further include being made necessary to various dosage forms in addition to the skincare composition beyond the region of objective existence containing glabridin and Ectoin in cosmetics
Matrix, matrix can choose the conventional substrate of each dosage form in the prior art, and cosmetics preparation method is according to prior art routine side
Method preparation.Content of the glabridin in cosmetics be 0.01-1wt%, preferably 0.05-0.5wt%, it is described according to gram more than
Because the content in cosmetics is 0.1-3wt%, preferably 0.5-2.5wt%.The entirely shield containing glabridin and Ectoin
Content of the skin composition in cosmetics is 10.11-33wt%.
In order to verify the excellent effect of the skin care compositions of the invention containing glabridin and Ectoin, by above-described embodiment
Nti-freckle essence cream is prepared into the skin care compositions of comparative example preparation and imports liquid, the method is as follows:
1 nti-freckle essence cream basic components of table
The crosslinking of -25 methacrylate of alcohol polyethers
Preparation method:
(1) A phase raw material is uniformly mixed and is warming up to 75 DEG C；
(2) 75 DEG C are warming up to after mixing B phase raw material；
(3) A phase and B are mixed and is stirred evenly, addition is warming up in 75 DEG C of C phase, is stirred evenly；
(4) homogeneous 3) in mixture 6000rpm 2min, slow cooling later；
(5) 45 DEG C or less addition D phases are cooled to, are stirred evenly, be cooled to room temperature discharging to get.
2 nti-freckle of table imports liquid basic components
Preparation method:
(1) A phase raw material is mixed evenly；
(2) B is added in A phase and is mixed evenly, discharging to get.
3 skin care compositions of table imports the content in liquid in nti-freckle essence cream and nti-freckle
Using the nti-freckle essence cream and importing liquid of above application examples preparation, the freckle effect of product of the present invention is tested
Card.
The experiment of 1 whitening effect of experimental example
(1) laboratory apparatus, sample and test crowd
Instrument: MPA980 Multi-functional skin tester (Mexameter MX18 melanin and ferroheme test probe,
Colorimeter CL400 skin color test probe).
Given the test agent: embodiment 1, embodiment 2, embodiment 3, embodiment 4, embodiment 5, comparative example 1, comparative example 2, comparison
Example 3, comparative example 4, the essence of blank group preparation are newborn, and wherein blank group is to be added without the essence cream matrix of C phase skin care compositions.
Test crowd: subject amounts to 80 people, divides 10 groups, and every group of 8 people, every group is tested using a kind of essence cream,
Other any cosmetics are not used in recipient site during test.Volunteer's exclusion condition meets " cosmetics contact dermatitis diagnosis
Standard and treatment principle " it is included in, exclusion criteria.
(2) experimental method
1. selecting the left and right arm of subject as tested region, the region 3cm × 3cm is selected to be tested, wherein right-hand man
Arm smears same trial target.
2. the skin before cosmetics is smeared using MPA980 Multi-functional skin tester measurement experiment position by technical staff
Melanin and skin brightness.
3. testing product is smeared in the tested area (the same area) cleaned by clear water sooner or later daily, during experiment, by
Examination person cannot apply the other any cosmetics erased outside tested sample in Test sites.
4. subject, after continuous use cosmetics 1,2,3,4 week, same time subject cleans position is smeared weekly,
Sit quietly 15min in fixed test environment, measures spreader portion bit value using test equipment by technical staff.
5. the numerical value that statistics subject position measures every time, the variation of analyzing skin melanin and skin brightness L value
Rule.
(3) interpretation of result
1. melanin content mutation analysis: dermal melanin changes of contents is characterized by melanin content difference, the difference energy
Reflect that Experimental Area dermal melanin content changes over time rule within test period.Its value is bigger, and dermal melanin contains
Amount is bigger, conversely, dermal melanin content is smaller.The melanin content difference for the subject for using identical product is averaged
Value, the melanin content result of variations as the product.
Melanin content difference (Δ T)=each time point melanin content (Tn)-after product is used to use black before product
Cellulose content (T0)
2. skin brightness mutation analysis: skin brightness variation is characterized by luminance difference, which can be reflected in test period
Interior Experimental Area skin brightness changes with time rule.Its value is bigger, and skin brightness is better, conversely, skin brightness is poorer.It is right
It is averaged using the luminance difference of the subject of identical product, the skin brightness result of variations as the product.
Luminance difference (Δ T)=each time point brightness value (Tn)-after product is used to use brightness value (T0) before product
The difference (average value) of table 4 different sample skin brightness contents and initial value
Table 3 and 4 data of table are analyzed, it will thus be seen that the composition of 1-5 of the embodiment of the present invention is shown centainly
The de-black pigment and skin lightening result of degree, because the different-effect size of effective ingredient consumption is variant, wherein containing embodiment 1
Best with the effect of 2 mass ratio and the product of the glabridin of content and Ectoin composition, embodiment 3 is compared most
Difference, this is because the relatively low reason of the content of glabridin and Ectoin in embodiment 3.
From the comparison of embodiment 1 and comparative example 1,2 as can be seen that the whitening function of the composition of glabridin and Ectoin
Whitening effect after effect has the effect of apparent synergy, the two to be used in compounding is substantially better than any single product of the two
Effect；From the comparison of embodiment 1 and comparative example 3,4 as can be seen that the glabridin of comparative example 3 and 4 and the matter of Ectoin
Ratio is measured in the scope of the present invention, but the optimized scope that content of each ingredient in essence cream is limited beyond the present invention, and
From the experimental results, the whitening effect of the product of embodiment 1, comparative example 3, comparative example 4 is not much different, it can thus be seen that light
The increase of the content of any one of licoricidin and Ectoin raw material will not all significantly improve white-skinned face function, therefore consider former
The cost problem of material, content of the glabridin in cosmetics is preferable lower than 1wt%, and content of the Ectoin in cosmetics is low
It is preferable in 3wt%.
2 chloasma of experimental example dispels experiment
1 is included in standard
1. meeting examining for the chloasma that Chinese Association of Chinese and Western Medicine Dermatology Professional Committee pigment disease group is drafted
Disconnected and criterion of therapeutical effect (revised draft in 2003)；2. not receiving the treatment means of other chloasma in the recent period；3. patient's informed consent.
2 exclusion criterias
1. excluding other diseases (such as Riehl melanose, pigmentosa actinic lichen planus and naevus fuscocaerules zygomaticus) to draw
The pigmentation risen；2. photaesthesia or the in the recent period person that takes photosensitive drug；3. cannot accomplish it is postoperative be protected from light or have within nearly 1 month be exposed to the sun through
The person of going through；4. once having thrombosis, angina pectoris, myocardial infarction, cerebral ischemia medical history person；5. gestation and breast feeding women；6. suffering from
Severe cardiovascular disease, liver and kidney disease, malignant tumour etc. and mental disease person；7. desired value is excessively high and mismatches curer.
Volunteer: source Mr. Yu hospital outpatient patient is divided into four groups each 30.Four groups of patient ages, the course of disease, state of an illness are through uniting
Meter learns processing, and there was no significant difference.
3 treatment methods
It imports liquid to import using needle roller or micropin nano-crystal, once a week；The daily smearing of essence cream, uses daily.Treatment 6
Efficacy determination is carried out after a month.
4 observation of curative effect and method
Referring to " Chinese chloasma treatment expert knows together (2015) " and " clinical diagnosis of chloasma and curative effect determinate standard
(revised draft in 2003) " standards of grading and curative effect determinate standard.
Patient's self-assessment: by questionnaire form, investigating patient to the satisfaction of curative effect, be divided into it is very satisfied (improve >=
75%), satisfied to improve (improvement 50%~75%), general (improving 25%~50%), dissatisfied (improving≤25%), count total
It is efficient.
Total effective rate=(test number-is unsatisfied with number)/test number.
5 results
Since whitening effect can not illustrate that well the effect of eliminate chloasma is good completely, and eliminate chloasma clinical test is opened
Difficult, the alternative personnel of exhibition it is few and it is time-consuming long, therefore only select representative embodiment 1, embodiment 3 and comparative example 5,
Importing liquid and essence cream prepared by comparative example 6 is tested.
As a result clinical curative effect analysis see the table below 5.
54 groups of Clinical efficacy comparisons of table
| Group | Number of cases | It is very satisfied | It is satisfied to improve | Generally | It is dissatisfied | Total effective rate (%) |
| Embodiment 1 | 30 | 26 | 2 | 1 | 1 | 96.7 |
| Embodiment 3 | 30 | 10 | 14 | 3 | 3 | 90 |
| Comparative example 5 | 30 | 5 | 9 | 10 | 6 | 80 |
| Comparative example 6 | 30 | 9 | 10 | 6 | 5 | 83.3 |
As can be seen from Table 5, the total effective rate of embodiment 1 and embodiment 3 is above comparative example 5 and comparative example 6.It adopts
Glabridin and Ectoin of the present invention are replaced with 2 kinds reported in the prior art common anti-freckle agent niacinamide and resveratrol
Any one of raw material, the effect of eliminate chloasma all obviously weaken, this sufficiently demonstrates glabridin and Yi Ke of the present invention
Mostly because combination significantly dispel effect compared to having with the combinations of other nti-freckle ingredients to chloasma.
Claims (10)
1. a kind of skin care compositions, it is characterized in that: effective component includes glabridin and Ectoin.
2. skin care compositions according to claim 1, it is characterized in that: the mass ratio of glabridin and Ectoin is 1:1-
25, preferred mass ratio is 1:3-5.
3. skin care compositions according to claim 1 or 2, it is characterized in that: further including organic solvent, the organic solvent is excellent
It is selected as glycerol, butanediol, pentanediol, dipropylene glycol or propylene glycol, more preferably glycerol or butanediol.
4. skin care compositions according to claim 3, it is characterized in that: the gross mass of glabridin and Ectoin and organic
The mass ratio of solvent is 1:10-20.
5. skin care compositions of any of claims 1-4 is preparing the application in cosmetics or external preparation for skin drug.
6. application according to claim 5 is preferably dispelled yellowish-brown it is characterized in that: the cosmetics are cosmetics
The cosmetics of spot；The external preparation for skin drug is nti-freckle topical drug, the preferably topical drug of eliminate chloasma.
7. a kind of cosmetics or external preparation for skin drug, it is characterized in that: including skincare composition of any of claims 1-4
Object；Preferably, content of the glabridin in cosmetics be 0.01-1wt%, preferably 0.05-0.5wt%, it is described according to gram
Mostly because the content in cosmetics is 0.1-3wt%, preferably 0.5-2.5wt%.
8. cosmetics according to claim 7, it is characterized in that: further including matrix components necessary to cosmetics, the base
Matter ingredient includes solvent, emulsifier and at least one of the preservatives.
9. cosmetics according to claim 7, it is characterized in that: the cosmetics include toner, essence, cream, frost, face
Film imports liquid or color make-up.
10. the cosmetics according to any one of claim 7-9 or external preparation for skin drug, it is characterized in that: the cosmetics
For cosmetics, the preferably cosmetics of eliminate chloasma；The external preparation for skin drug is nti-freckle topical drug, is preferably dispelled
Except the topical drug of chloasma.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115068362A (en) * | 2021-08-09 | 2022-09-20 | 昆山巨星行动电子商务有限公司 | Collagen composition, micro essence containing composition and preparation method of micro essence |
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Application publication date: 20190813 |