CN115068362B - Collagen composition, micro-essence containing composition and preparation method of composition - Google Patents
Collagen composition, micro-essence containing composition and preparation method of composition Download PDFInfo
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- CN115068362B CN115068362B CN202110908758.5A CN202110908758A CN115068362B CN 115068362 B CN115068362 B CN 115068362B CN 202110908758 A CN202110908758 A CN 202110908758A CN 115068362 B CN115068362 B CN 115068362B
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- skin
- micro
- sodium hyaluronate
- composition
- collagen
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- 102000008186 Collagen Human genes 0.000 title claims abstract description 71
- 108010035532 Collagen Proteins 0.000 title claims abstract description 71
- 229920001436 collagen Polymers 0.000 title claims abstract description 71
- 239000000203 mixture Substances 0.000 title claims abstract description 70
- 238000002360 preparation method Methods 0.000 title claims abstract description 6
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims abstract description 42
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000006210 lotion Substances 0.000 claims abstract description 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 72
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 49
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 49
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 49
- 238000000855 fermentation Methods 0.000 claims description 39
- 230000004151 fermentation Effects 0.000 claims description 39
- 240000002791 Brassica napus Species 0.000 claims description 31
- 235000004977 Brassica sinapistrum Nutrition 0.000 claims description 31
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims description 31
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 31
- QYDYPVFESGNLHU-UHFFFAOYSA-N elaidic acid methyl ester Natural products CCCCCCCCC=CCCCCCCCC(=O)OC QYDYPVFESGNLHU-UHFFFAOYSA-N 0.000 claims description 31
- 239000008103 glucose Substances 0.000 claims description 31
- QYDYPVFESGNLHU-KHPPLWFESA-N methyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC QYDYPVFESGNLHU-KHPPLWFESA-N 0.000 claims description 31
- 229940073769 methyl oleate Drugs 0.000 claims description 31
- YPUZOECTETYPRF-UHFFFAOYSA-N 1,2,3,4-tetrahydropyrimidine-2-carboxylic acid Chemical compound OC(=O)C1NCC=CN1 YPUZOECTETYPRF-UHFFFAOYSA-N 0.000 claims description 25
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims description 25
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 24
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 24
- RGUVUPQQFXCJFC-UHFFFAOYSA-N n-hydroxyoctanamide Chemical compound CCCCCCCC(=O)NO RGUVUPQQFXCJFC-UHFFFAOYSA-N 0.000 claims description 24
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims description 23
- 150000002148 esters Chemical class 0.000 claims description 23
- 229940119170 jojoba wax Drugs 0.000 claims description 23
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims description 21
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 20
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 20
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 18
- 239000001140 aloe barbadensis leaf extract Substances 0.000 claims description 17
- 229940069638 aloe vera leaf extract Drugs 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 13
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 11
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 11
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 11
- 238000001816 cooling Methods 0.000 claims description 9
- 238000001914 filtration Methods 0.000 claims description 9
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 5
- 241000289690 Xenarthra Species 0.000 claims description 5
- 239000007788 liquid Substances 0.000 abstract description 10
- 239000008139 complexing agent Substances 0.000 abstract description 9
- 239000003906 humectant Substances 0.000 abstract description 8
- 239000000419 plant extract Substances 0.000 abstract description 8
- 150000002840 non-reducing disaccharides Chemical class 0.000 abstract description 7
- 238000010521 absorption reaction Methods 0.000 abstract description 6
- 230000032683 aging Effects 0.000 abstract description 5
- 239000003974 emollient agent Substances 0.000 abstract description 5
- 230000003712 anti-aging effect Effects 0.000 abstract description 4
- 239000002994 raw material Substances 0.000 abstract description 4
- 230000008929 regeneration Effects 0.000 abstract description 4
- 238000011069 regeneration method Methods 0.000 abstract description 4
- 229920000832 Cutin Polymers 0.000 abstract description 3
- 239000003242 anti bacterial agent Substances 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 45
- 239000000284 extract Substances 0.000 description 16
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 description 12
- 229960004768 irinotecan Drugs 0.000 description 12
- 239000000022 bacteriostatic agent Substances 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 230000003020 moisturizing effect Effects 0.000 description 5
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical class NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 description 4
- 229940069521 aloe extract Drugs 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 239000012535 impurity Substances 0.000 description 4
- 238000011056 performance test Methods 0.000 description 4
- 230000008591 skin barrier function Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000005260 corrosion Methods 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- JFQWHJPQSSMFMH-UHFFFAOYSA-N methyl 4,5,6-trimethylpyrimidine-2-carboxylate Chemical compound COC(=O)C1=NC(=C(C(=N1)C)C)C JFQWHJPQSSMFMH-UHFFFAOYSA-N 0.000 description 3
- 230000035699 permeability Effects 0.000 description 3
- 230000002087 whitening effect Effects 0.000 description 3
- 230000037303 wrinkles Effects 0.000 description 3
- 229920002101 Chitin Polymers 0.000 description 2
- 244000260524 Chrysanthemum balsamita Species 0.000 description 2
- 235000005633 Chrysanthemum balsamita Nutrition 0.000 description 2
- 241000628997 Flos Species 0.000 description 2
- DRAJWRKLRBNJRQ-UHFFFAOYSA-N Hydroxycarbamic acid Chemical class ONC(O)=O DRAJWRKLRBNJRQ-UHFFFAOYSA-N 0.000 description 2
- 241000132446 Inula Species 0.000 description 2
- 240000000249 Morus alba Species 0.000 description 2
- 235000008708 Morus alba Nutrition 0.000 description 2
- 240000005546 Piper methysticum Species 0.000 description 2
- 235000016787 Piper methysticum Nutrition 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- 235000006468 Thea sinensis Nutrition 0.000 description 2
- 241000028204 Vincetoxicum atratum Species 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 230000004075 alteration Effects 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 235000020279 black tea Nutrition 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 229960005188 collagen Drugs 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 229940072117 fennel extract Drugs 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 229940069445 licorice extract Drugs 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- 229940116257 pepper extract Drugs 0.000 description 2
- 229940064064 purslane extract Drugs 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 210000004927 skin cell Anatomy 0.000 description 2
- 230000037394 skin elasticity Effects 0.000 description 2
- 239000001509 sodium citrate Substances 0.000 description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 125000000647 trehalose group Chemical group 0.000 description 2
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 description 1
- 235000008658 Artemisia capillaris Nutrition 0.000 description 1
- 241000092668 Artemisia capillaris Species 0.000 description 1
- 235000003092 Artemisia dracunculus Nutrition 0.000 description 1
- 240000001851 Artemisia dracunculus Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 229940100524 ethylhexylglycerin Drugs 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 238000012009 microbiological test Methods 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229960001790 sodium citrate Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A61Q19/08—Anti-ageing preparations
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Emergency Medicine (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the technical field of skin care products, and particularly relates to a collagen composition, a micro-essence containing the composition and a preparation method thereof. The invention belongs to the technical field of skin care products, and particularly relates to a collagen composition, a micro-essence containing the composition and a preparation method thereof. A micro essence lotion is prepared from the raw materials of the collagen composition, p-hydroxyacetophenone, non-reducing disaccharide, complexing agent, plant extract, emollient, antibacterial agent, humectant and water. The micro essence liquid in the technical scheme can regulate the water-oil balance of the skin, soften cutin, improve the absorption capacity of the skin to collagen, maintain the elasticity of cells, promote the regeneration of damaged tissues, improve the repairing capacity of the skin and delay the aging of cells, thereby achieving the purposes of maintaining the elasticity of the skin and improving the anti-aging capacity of the skin.
Description
Technical Field
The invention belongs to the technical field of skin care products, and particularly relates to a collagen composition, a micro-essence containing the composition and a preparation method thereof.
Background
With the increasing development of economy, consumers are increasingly concerned with their skin condition, and their skin can be kept young by using correct skin care products. With age, the absorption capacity of the skin, the moisturizing mechanism and the barrier repair system are damaged, the resistance of the skin is also deteriorated, and the skin is dry and loses elasticity. With the increase of life rhythm, the phenomenon of staying up is generalized, the movement amount of the whole people is greatly reduced due to the use of excessive digital products, the skin metabolism is slowed down due to unhealthy life laws and normal aging, excessive sugar is free in blood, the free sugar is attached to collagen, the collagen is broken or disturbed, and the skin is rough and wrinkles are generated. The existing skin care product only has basic moisturizing effect, and has no good effect on the absorption capacity, water-oil balance capacity and skin resistance capacity of the skin.
Disclosure of Invention
In order to solve the above technical problems, a first aspect of the present invention provides a collagen composition, which at least comprises soluble collagen, a fermentation product, sodium hyaluronate and tetrahydropyrimidine carboxylic acid.
Preferably, dipotassium glycyrrhizinate is also included.
Preferably, the fermentation product is candida/glucose/rapeseed methyl oleate fermentation product.
The second aspect of the invention provides a micro-essence lotion, which is prepared from the raw materials of the collagen composition, the p-hydroxyacetophenone, the non-reducing disaccharide, the complexing agent, the plant extract, the emollient, the bacteriostatic agent, the humectant and the water.
Preferably, the non-reducing disaccharide is trehalose.
Preferably, the complexing agent is selected from at least one of aminocarboxylic acids, hydroxycarboxylic acids, and hydroxyaminocarboxylic acids.
Preferably, the plant extract is selected from at least one of aloe extract, licorice extract, fennel extract, artemisia capillaris extract, mulberry bark extract, black tea extract, purslane extract, flos Rosae Multiflorae extract, daisy flower extract, inula flower extract, kava pepper extract, cynanchum atratum extract and small fruit coffee seed extract.
Preferably, the bacteriostatic agent at least comprises octanoyl hydroxamic acid.
Preferably, the humectant is selected from at least one of alcohols, amides, chitin and derivatives thereof.
The third aspect of the present invention provides a method for preparing the micro-essence, at least comprising the steps of:
(1) Adding p-hydroxyacetophenone and water into a container at 50-60 ℃ to obtain a mixture A;
(2) And (3) cooling the mixture in the container in the step (1) to 30-40 ℃, adding the collagen composition, the non-reducing disaccharide, the complexing agent, the plant extract, the emollient, the bacteriostatic agent and the humectant, filtering, and checking to be qualified.
The beneficial effects are that: according to the technical scheme, the inventor can make the collagen composition deeply enter the skin by adding a fermentation product into the soluble collagen, improve the permeability of the collagen composition, regulate the water-oil balance of the skin, soften keratin, improve the absorption capacity of the skin to the collagen, maintain the elasticity of cells, promote the regeneration of damaged tissues, improve the repairing capacity of the skin and delay the aging of the cells, so that the purposes of maintaining the elasticity of the skin and improving the anti-aging capacity of the skin are achieved. The inventor adds sodium hyaluronate to improve the content of sodium hyaluronate in skin cell interstitial, so as to change the metabolic environment of cells and the balance of water and ions, thereby improving the viscoelasticity and moisture retention of skin and improving the lubrication degree of skin, and further achieving the effects of resisting wrinkles, preserving moisture, lubricating and whitening. The inventor adds a certain amount of tetrahydropyrimidine carboxylic acid to strengthen the repairing capability of a skin barrier repairing system, strengthen the skin barrier function, improve the capability of skin for resisting external environment, build skin micro balance, maintain the moisture degree of the skin and reproduce the skin activity.
Detailed Description
For the purposes of the following detailed description, it is to be understood that the invention may assume various alternative variations and step sequences, except where expressly specified to the contrary. Furthermore, except in any operating examples, or where otherwise indicated, all numbers expressing, for example, quantities of ingredients used in the specification and claims are to be understood as being modified in all instances by the term "about". Accordingly, unless indicated to the contrary, the numerical parameters set forth in the following specification and attached claims are approximations that may vary depending upon the desired properties to be obtained by the present invention. At the very least, and not as an attempt to limit the application of the doctrine of equivalents to the scope of the claims, each numerical parameter should at least be construed in light of the number of reported significant digits and by applying ordinary rounding techniques.
Notwithstanding that the numerical ranges and parameters setting forth the broad scope of the invention are approximations, the numerical values set forth in the specific examples are reported as precisely as possible. Any numerical value, however, inherently contains certain errors necessarily resulting from the standard deviation found in their respective testing measurements.
When a range of values is disclosed herein, the range is considered to be continuous and includes both the minimum and maximum values for the range, as well as each value between such minimum and maximum values. Further, when a range refers to an integer, each integer between the minimum and maximum values of the range is included. Further, when multiple range description features or characteristics are provided, the ranges may be combined. In other words, unless otherwise indicated, all ranges disclosed herein are to be understood to include any and all subranges subsumed therein. For example, a specified range from "1 to 10" should be considered to include any and all subranges between the minimum value of 1 and the maximum value of 10. Exemplary subranges from 1 to 10 include, but are not limited to, 1 to 6.1, 3.5 to 7.8, 5.5 to 10, and the like.
In order to solve the above technical problems, a first aspect of the present invention provides a collagen composition, which at least comprises soluble collagen, a fermentation product, sodium hyaluronate and tetrahydropyrimidine carboxylic acid.
As a preferred technical scheme, the mass ratio of the soluble collagen, the fermentation product, the sodium hyaluronate and the tetrahydropyrimidine carboxylic acid is (3-7): (0.5-1.5): (1-3): (3-4).
As a preferred technical solution, the mass ratio of the soluble collagen, the fermentation product, the sodium hyaluronate and the tetrahydropyrimidine carboxylic acid is between 5:1:2:3.4.
As a preferred technical scheme, the molecular weight of the sodium hyaluronate is less than 10000Da.
The inventor finds that by adding a fermentation product into the soluble collagen, the collagen composition can be deeply put into the skin, the permeability of the collagen composition is improved, the water-oil balance of the skin is regulated, the cutin is softened, the absorption capacity of the skin to the collagen is improved, the cell elasticity is maintained, the regeneration of damaged tissues is promoted, the repairing capacity of the skin is improved, and the aging of cells is delayed, so that the purposes of maintaining the skin elasticity and improving the anti-aging capacity of the skin are achieved. The inventor adds sodium hyaluronate to improve the content of sodium hyaluronate in the interstitial of skin cells, so as to change the metabolic environment of the cells and the balance of water and ions, thereby increasing the viscoelasticity and the moisture retention of the skin and achieving the effects of resisting wrinkles, preserving moisture and whitening. The inventor adds a certain amount of tetrahydropyrimidine carboxylic acid to strengthen the repairing capability of a skin barrier repairing system, strengthen the skin barrier function, improve the capability of skin for resisting external environment, build skin micro balance, maintain the moisture degree of the skin and reproduce the skin activity. The moisturizing effect of the skin can be better improved by adding a certain content of sodium hyaluronate, but when the adding amount of sodium hyaluronate is too small, the moisturizing effect is not ideal, and when the adding amount of sodium hyaluronate is large, as sodium hyaluronate has better hygroscopicity, under the condition of long-time use, sodium hyaluronate can absorb more impurities in the environment, the stability of the collagen composition is affected, even liquid turbidity phenomenon can occur, and the inventor discovers that the comfort of the collagen composition is slightly poor.
As a preferable technical scheme, the method also comprises dipotassium glycyrrhizinate.
The inventor finds that the moisturizing effect and the whitening effect of the collagen composition can be improved, the antibacterial and anti-inflammatory effects of the collagen composition can be improved, the sensibility and the irritation of the collagen composition are reduced, the relieving effect of the collagen composition is improved, and the audience of the collagen composition is enlarged through a certain amount of dipotassium glycyrrhizinate.
As a preferred technical scheme, the fermentation product is candida/glucose/rapeseed methyl oleate fermentation product.
The inventor finds that the candida/glucose/rapeseed methyl oleate fermentation product is especially selected, so that the collagen composition can be deeply put into the skin, the permeability of the collagen composition is improved, the water-oil balance of the skin is regulated, the cutin is softened, the absorption capacity of the skin to the collagen is improved, the cell elasticity is maintained, the regeneration of damaged tissues is promoted, the repairing capacity of the skin is improved, the aging of cells is delayed, the purposes of maintaining the skin elasticity, improving the anti-aging capacity of the skin are achieved, the antibacterial property of the skin is better improved, and the sensibility of the skin is reduced.
The second aspect of the invention provides a micro-essence lotion, which is prepared from the raw materials of the collagen composition, the p-hydroxyacetophenone, the non-reducing disaccharide, the complexing agent, the plant extract, the emollient, the bacteriostatic agent, the humectant and the water.
As a preferable embodiment, the non-reducing disaccharide is trehalose.
The inventor can make the micro-essence liquid form a layer of protective film on the surface of the skin by adding a certain amount of trehalose into the micro-essence liquid, so that the antibacterial property of the skin is improved, the immunity and the repair capability of the skin are improved, but trace impurities possibly exist in the trehalose to influence the stability of the essence liquid.
As a preferred embodiment, the complexing agent is at least one selected from the group consisting of aminocarboxylic acids, hydroxycarboxylic acids and hydroxyaminocarboxylic acids.
As a preferable technical scheme, the bacteriostatic agent at least comprises octanoyl hydroxamic acid.
As a preferable technical scheme, the bacteriostatic agent also comprises 1, 2-hexanediol, ethylhexyl glycerol and propylene glycol.
As a preferable technical scheme, the complexing agent is amino carboxylic acid, and the amino carboxylic acid is disodium ethylenediamine tetraacetate.
As a preferable technical scheme, the mass ratio of the bacteriostatic agent to the complexing agent is 23:5.
The inventor finds that the mixture of octanoyl hydroxamic acid, 1, 2-hexanediol, ethylhexyl glycerol and propylene glycol not only can lead the micro-essence to have better antibacterial effect, but also can improve the anti-corrosion performance of the micro-essence. However, the inventors found that the antibacterial agent is easily affected by impurities in the remaining substances to reduce stability and corrosion resistance, and unexpectedly found that the stability, the antioxidant property, the corrosion resistance and the antioxidant effect of the micro-essence can be improved by adding a certain amount of disodium ethylenediamine tetraacetate and complexing impurities in the essence, but when the amount of disodium ethylenediamine tetraacetate is excessively added, the use effect of the micro-essence is affected, and when the amount of disodium ethylenediamine tetraacetate is excessively small, the stability of the micro-essence is affected.
As a preferred embodiment, the plant extract is selected from at least one of aloe extract, licorice extract, fennel extract, tarragon extract, mulberry bark extract, black tea extract, purslane extract, flos Rosae Multiflorae extract, daisy flower extract, inula flower extract, kava pepper extract, cynanchum atratum extract and small fruit coffee seed extract.
As a preferred technical scheme, the plant extract is aloe extract, and the aloe extract is aloe vera leaf extract.
As a preferred technical scheme, the softener is jojoba wax PEG-120 esters.
As a preferable technical scheme, the humectant is selected from at least one of alcohols, amides, chitin and derivatives thereof.
As a preferable technical scheme, the humectant is alcohol, and the alcohol is glycerol.
The third aspect of the present invention provides a method for preparing the micro-essence, at least comprising the steps of:
(1) Adding p-hydroxyacetophenone and water into a container at 50-60 ℃ to obtain a mixture A;
(2) And (3) cooling the mixture in the container in the step (1) to 30-40 ℃, adding the collagen composition, the non-reducing disaccharide, the complexing agent, the plant extract, the emollient, the bacteriostatic agent and the humectant, filtering, and checking to be qualified.
In addition, the raw materials used are commercially available unless otherwise indicated.
Example 1
To solve the above-mentioned technical problem, a first aspect of the present embodiment provides a collagen composition comprising soluble collagen, candida/glucose/rapeseed methyl oleate fermentation product, sodium hyaluronate, tetrahydropyrimidine carboxylic acid and dipotassium glycyrrhizinate.
The second aspect of this example provides a micro-essence lotion comprising, by weight, 100 parts of p-hydroxyacetophenone, 0.3 part of trehalose, 0.01 part of sodium hyaluronate, 0.03 part of soluble collagen, 0.05 part of disodium edentate, 0.4 part of dipotassium glycyrrhizate, 0.015 part of aloe vera leaf extract, 0.05 part of candida/glucose/rapeseed methyl oleate fermentation product, 0.14 part of jojoba wax PEG-120 esters, 0.03 part of tetramethylpyrimidine carboxylic acid, 0.23 part of octanoyl hydroxamic acid, 1, 2-hexanediol, ethylhexyl glycerol and propylene glycol in total, and the balance of water. The molecular weight of the sodium hyaluronate is less than 10000Da, and the sodium hyaluronate is purchased from Shandong focus biotechnology Co. The soluble collagen is purchased from Tianjin irinotecan biotechnology Co., ltd, the candida/glucose/rapeseed methyl oleate fermentation product is purchased from Tianjin irinotecan biotechnology Co., ltd, the jojoba wax PEG-120 esters are purchased from HALLSTAR, and the mixture of octanoyl hydroxamic acid, 1, 2-hexanediol, ethylhexyl glycerol and propylene glycol is purchased from Beijing Sanepper biochemical technology Co.
The third aspect of the present embodiment provides a method for preparing the micro-essence, which comprises the following steps:
(1) Adding p-hydroxyacetophenone and water into a container at 50 ℃ to obtain a mixture A;
(2) And (3) cooling the mixture in the container in the step (1) to 40 ℃, adding trehalose, sodium hyaluronate, soluble collagen, disodium ethylenediamine tetraacetate, dipotassium glycyrrhizinate, aloe vera leaf extract, candida/glucose/rapeseed methyl oleate fermentation product, jojoba wax PEG-120 esters, tetrahydropyrimidine carboxylic acid, octanoyl hydroxamic acid, 1, 2-hexanediol, ethylhexyl glycerol and propylene glycol, and filtering and checking to be qualified.
Example 2
To solve the above-mentioned technical problem, a first aspect of the present embodiment provides a collagen composition comprising soluble collagen, candida/glucose/rapeseed methyl oleate fermentation product, sodium hyaluronate, tetrahydropyrimidine carboxylic acid and dipotassium glycyrrhizinate.
The second aspect of this example provides a micro-essence lotion comprising, by weight, 100 parts of p-hydroxyacetophenone, 0.3 part of trehalose, 0.02 part of sodium hyaluronate, 0.05 part of soluble collagen, 0.05 part of disodium edentate, 0.4 part of dipotassium glycyrrhizate, 0.015 part of aloe vera leaf extract, 0.01 part of candida/glucose/rapeseed methyl oleate fermentation product, 0.14 part of jojoba wax PEG-120 esters, 0.034 part of tetramethylpyrimidine carboxylic acid, 0.23 part of octanoyl hydroxamic acid, 1, 2-hexanediol, ethylhexyl glycerol and propylene glycol in total, and the balance of water. The molecular weight of the sodium hyaluronate is less than 10000Da, and the sodium hyaluronate is purchased from Shandong focus biotechnology Co. The soluble collagen is purchased from Tianjin irinotecan biotechnology Co., ltd, the candida/glucose/rapeseed methyl oleate fermentation product is purchased from Tianjin irinotecan biotechnology Co., ltd, the jojoba wax PEG-120 esters are purchased from HALLSTAR, and the mixture of octanoyl hydroxamic acid, 1, 2-hexanediol, ethylhexyl glycerol and propylene glycol is purchased from Beijing Sanepper biochemical technology Co.
The third aspect of the present embodiment provides a method for preparing the micro-essence, which comprises the following steps:
(1) Adding p-hydroxyacetophenone and water into a container at 50 ℃ to obtain a mixture A;
(2) And (3) cooling the mixture in the container in the step (1) to 40 ℃, adding trehalose, sodium hyaluronate, soluble collagen, disodium ethylenediamine tetraacetate, dipotassium glycyrrhizinate, aloe vera leaf extract, candida/glucose/rapeseed methyl oleate fermentation product, jojoba wax PEG-120 esters, tetrahydropyrimidine carboxylic acid, octanoyl hydroxamic acid, 1, 2-hexanediol, ethylhexyl glycerol and propylene glycol, and filtering and checking to be qualified.
Example 3
To solve the above-mentioned technical problem, a first aspect of the present embodiment provides a collagen composition comprising soluble collagen, candida/glucose/rapeseed methyl oleate fermentation product, sodium hyaluronate, tetrahydropyrimidine carboxylic acid and dipotassium glycyrrhizinate.
The second aspect of this example provides a micro-essence lotion, which comprises, by weight, 100 parts of p-hydroxyacetophenone, 0.2 part of trehalose, 0.3 part of sodium hyaluronate, 0.03 part of soluble collagen, 0.07 part of disodium edentate, 0.05 part of dipotassium glycyrrhizate, 0.015 part of aloe vera leaf extract, 0.015 part of candida/glucose/rapeseed methyl oleate fermentation product, 0.14 part of jojoba wax PEG-120 esters, 0.04 part of tetramethylpyrimidine carboxylic acid, 0.23 part of a mixture of octanoyl hydroxamic acid, 1, 2-hexanediol, ethylhexyl glycerol and propylene glycol, and the balance of water. The molecular weight of the sodium hyaluronate is less than 10000Da, and the sodium hyaluronate is purchased from Shandong focus biotechnology Co. The soluble collagen is purchased from Tianjin irinotecan biotechnology Co., ltd, the candida/glucose/rapeseed methyl oleate fermentation product is purchased from Tianjin irinotecan biotechnology Co., ltd, the jojoba wax PEG-120 esters are purchased from HALLSTAR, and the mixture of octanoyl hydroxamic acid, 1, 2-hexanediol, ethylhexyl glycerol and propylene glycol is purchased from Beijing Sanepper biochemical technology Co.
The third aspect of the present embodiment provides a method for preparing the micro-essence, which comprises the following steps:
(1) Adding p-hydroxyacetophenone and water into a container at 50 ℃ to obtain a mixture A;
(2) And (3) cooling the mixture in the container in the step (1) to 40 ℃, adding trehalose, sodium hyaluronate, soluble collagen, disodium ethylenediamine tetraacetate, dipotassium glycyrrhizinate, aloe vera leaf extract, candida/glucose/rapeseed methyl oleate fermentation product, jojoba wax PEG-120 esters, tetrahydropyrimidine carboxylic acid, octanoyl hydroxamic acid, 1, 2-hexanediol, ethylhexyl glycerol and propylene glycol, and filtering and checking to be qualified.
Example 4
To solve the above-mentioned technical problem, a first aspect of the present embodiment provides a collagen composition comprising soluble collagen, candida/glucose/rapeseed methyl oleate fermentation product, sodium hyaluronate, tetrahydropyrimidine carboxylic acid and dipotassium glycyrrhizinate.
The second aspect of this example provides a micro-essence lotion comprising, by weight, 100 parts of p-hydroxyacetophenone, 0.3 part of trehalose, 1 part of sodium hyaluronate, 0.05 part of soluble collagen, 0.05 part of disodium edentate, 0.4 part of dipotassium glycyrrhizate, 0.015 part of aloe vera leaf extract, 0.01 part of candida/glucose/rapeseed methyl oleate fermentation product, 0.14 part of jojoba wax PEG-120 esters, 0.034 part of tetrahydropyrimidine carboxylic acid, 0.23 part of octanoyl hydroxamic acid, 1, 2-hexanediol, ethylhexyl glycerol and propylene glycol in total, and the balance of water. The molecular weight of the sodium hyaluronate is less than 10000Da, and the sodium hyaluronate is purchased from Shandong focus biotechnology Co. The soluble collagen is purchased from Tianjin irinotecan biotechnology Co., ltd, the candida/glucose/rapeseed methyl oleate fermentation product is purchased from Tianjin irinotecan biotechnology Co., ltd, the jojoba wax PEG-120 esters are purchased from HALLSTAR, and the mixture of octanoyl hydroxamic acid, 1, 2-hexanediol, ethylhexyl glycerol and propylene glycol is purchased from Beijing Sanepper biochemical technology Co.
The third aspect of the present embodiment provides a method for preparing the micro-essence, which comprises the following steps:
(1) Adding p-hydroxyacetophenone and water into a container at 50 ℃ to obtain a mixture A;
(2) And (3) cooling the mixture in the container in the step (1) to 40 ℃, adding trehalose, sodium hyaluronate, soluble collagen, disodium ethylenediamine tetraacetate, dipotassium glycyrrhizinate, aloe vera leaf extract, candida/glucose/rapeseed methyl oleate fermentation product, jojoba wax PEG-120 esters, tetrahydropyrimidine carboxylic acid, octanoyl hydroxamic acid, 1, 2-hexanediol, ethylhexyl glycerol and propylene glycol, and filtering and checking to be qualified.
Example 5
To solve the above-mentioned technical problem, a first aspect of the present embodiment provides a collagen composition comprising soluble collagen, candida/glucose/rapeseed methyl oleate fermentation product, sodium hyaluronate, tetrahydropyrimidine carboxylic acid and dipotassium glycyrrhizinate.
The second aspect of this example provides a micro-essence lotion comprising, by weight, 100 parts of p-hydroxyacetophenone, 0.3 part of trehalose, 0.02 part of sodium hyaluronate, 0.05 part of soluble collagen, 0.4 part of dipotassium glycyrrhizinate, 0.015 part of aloe vera leaf extract, 0.01 part of candida/glucose/rapeseed methyl oleate fermentation product, 0.14 part of jojoba wax PEG-120 esters, 0.034 part of tetrahydropyrimidine carboxylic acid, 0.23 part of octanoyl hydroxamic acid, 1, 2-hexanediol, ethylhexyl glycerol and propylene glycol mixture, and the balance of water. The molecular weight of the sodium hyaluronate is less than 10000Da, and the sodium hyaluronate is purchased from Shandong focus biotechnology Co. The soluble collagen is purchased from Tianjin irinotecan biotechnology Co., ltd, the candida/glucose/rapeseed methyl oleate fermentation product is purchased from Tianjin irinotecan biotechnology Co., ltd, the jojoba wax PEG-120 esters are purchased from HALLSTAR, and the mixture of octanoyl hydroxamic acid, 1, 2-hexanediol, ethylhexyl glycerol and propylene glycol is purchased from Beijing Sanepper biochemical technology Co.
The third aspect of the present embodiment provides a method for preparing the micro-essence, which comprises the following steps:
(1) Adding p-hydroxyacetophenone and water into a container at 50 ℃ to obtain a mixture A;
(2) And (3) cooling the mixture in the container in the step (1) to 40 ℃, adding trehalose, sodium hyaluronate, soluble collagen, dipotassium glycyrrhizinate, aloe vera leaf extract, candida/glucose/rapeseed methyl oleate fermentation products, the mixture of jojoba wax PEG-120 esters, tetrahydropyrimidine carboxylic acid, octanoyl hydroxamic acid, 1, 2-hexanediol, ethylhexyl glycerol and propylene glycol, and filtering and checking to be qualified.
Example 6
To solve the above-mentioned technical problem, a first aspect of the present embodiment provides a collagen composition comprising soluble collagen, candida/glucose/rapeseed methyl oleate fermentation product, sodium hyaluronate, tetrahydropyrimidine carboxylic acid and dipotassium glycyrrhizinate.
The second aspect of this example provides a micro-essence lotion comprising, by weight, 100 parts of p-hydroxyacetophenone, 0.3 part of trehalose, 0.02 part of sodium hyaluronate, 0.05 part of soluble collagen, 0.05 part of sodium citrate, 0.4 part of dipotassium glycyrrhizinate, 0.015 part of aloe vera leaf extract, 0.01 part of candida/glucose/rapeseed methyl oleate fermentation product, 0.14 part of jojoba wax PEG-120 esters, 0.034 part of tetrahydropyrimidine carboxylic acid, 0.23 part of a mixture of octanoic acid, 1, 2-hexanediol, ethylhexyl glycerol and propylene glycol, and the balance of water. The molecular weight of the sodium hyaluronate is less than 10000Da, and the sodium hyaluronate is purchased from Shandong focus biotechnology Co. The soluble collagen is purchased from Tianjin irinotecan biotechnology Co., ltd, the candida/glucose/rapeseed methyl oleate fermentation product is purchased from Tianjin irinotecan biotechnology Co., ltd, the jojoba wax PEG-120 esters are purchased from HALLSTAR, and the mixture of octanoyl hydroxamic acid, 1, 2-hexanediol, ethylhexyl glycerol and propylene glycol is purchased from Beijing Sanepper biochemical technology Co.
The third aspect of the present embodiment provides a method for preparing the micro-essence, which comprises the following steps:
(1) Adding p-hydroxyacetophenone and water into a container at 50 ℃ to obtain a mixture A;
(2) And (3) cooling the mixture in the container in the step (1) to 40 ℃, adding trehalose, sodium hyaluronate, soluble collagen, sodium citrate, dipotassium glycyrrhizinate, aloe vera leaf extract, candida/glucose/rapeseed methyl oleate fermentation products, jojoba wax PEG-120 esters, tetrahydropyrimidine carboxylic acid, octanoyl hydroxamic acid, 1, 2-hexanediol, ethylhexyl glycerin and propylene glycol, and filtering and checking to be qualified.
Performance test:
Performance test 1
The micro-essence prepared in the examples 1-3 is used for detecting the content of lead, arsenic, mercury and methanol according to a sanitary inspection method in cosmetic sanitary Specification (2015 edition), wherein the record meeting the index is qualified, otherwise, the record is unqualified; the microbiological condition in examples 1-3 was tested according to cosmetic health Specification (2015 edition) "microbiological test method", wherein the record of compliance with the index was passed, otherwise the record was failed, and the test results are shown in Table 1.
Performance test II
The micro serum prepared in example 1-example 3 was smelled, the smell was judged, and the pH and the density were tested, wherein the test results are shown in table 2.
Performance test III
Placing the micro-essence liquid in the examples 1-6 at room temperature for 24 hours, observing whether the micro-essence liquid is colorless transparent liquid, if so, recording the room temperature stability as qualified, and if not, recording the room temperature stability as unqualified; placing the micro-essence in the examples 1-6 at the temperature of (40+/-1) ℃ for 24 hours, after the temperature of the micro-essence is recovered to the room temperature, observing whether the micro-essence is colorless transparent liquid, if so, recording the high-temperature stability as qualified, and if not, recording the high-temperature stability as unqualified; the micro-essence of example 1-example 6 was left at (5.+ -. 1) ℃ for 24 hours, after the temperature was restored to room temperature, it was observed whether the micro-essence was colorless transparent liquid, if so, the low temperature stability was recorded as acceptable, and if not, the low temperature stability was recorded as unacceptable, wherein the test results are shown in Table 3.
TABLE 1
TABLE 2
| Smell of | pH | Density (kg/m 3) | |
| Example 1 | No fragrance, weak mellow taste | 4.5 | 0.98 |
| Example 2 | No fragrance, weak mellow taste | 4.7 | 0.99 |
| Example 3 | No fragrance, weak mellow taste | 4.5 | 1.02 |
TABLE 3 Table 3
| Room temperature stability | High temperature stability | Low temperature stability | |
| Example 1 | Qualified product | Qualified product | Qualified product |
| Example 2 | Qualified product | Qualified product | Qualified product |
| Example 3 | Qualified product | Qualified product | Qualified product |
| Example 4 | Failure to pass | Failure to pass | Failure to pass |
| Example 5 | Failure to pass | Failure to pass | Failure to pass |
| Example 6 | Failure to pass | Failure to pass | Failure to pass |
The above description is only a preferred embodiment of the present invention, and is not intended to limit the invention in any way, and any person skilled in the art may make modifications or alterations to the disclosed technical content to equivalent embodiments without departing from the technical content of the present invention, and any simple modification, equivalent changes and alterations to the above embodiments according to the technical substance of the present invention still fall within the scope of the technical solution of the present invention.
Claims (4)
1. The micro essence lotion is characterized by comprising, by weight, 100 parts of p-hydroxyacetophenone, 0.3 part of trehalose, 0.01 part of sodium hyaluronate, 0.03 part of soluble collagen, 0.05 part of disodium ethylenediamine tetraacetate, 0.4 part of dipotassium glycyrrhizinate, 0.015 part of aloe vera leaf extract, 0.05 part of candida/glucose/rapeseed methyl oleate fermentation product, 0.14 part of jojoba wax PEG-120 esters, 0.03 part of tetrahydropyrimidine carboxylic acid, 0.23 part of a mixture of octanoyl hydroxamic acid, 1, 2-hexanediol, ethylhexyl glycerol and propylene glycol, and the balance of water; the molecular weight of the sodium hyaluronate is less than 10000Da.
2. The micro essence lotion is characterized by comprising, by weight, 100 parts of p-hydroxyacetophenone, 0.3 part of trehalose, 0.02 part of sodium hyaluronate, 0.05 part of soluble collagen, 0.05 part of disodium ethylenediamine tetraacetate, 0.4 part of dipotassium glycyrrhizinate, 0.015 part of aloe vera leaf extract, 0.01 part of candida/glucose/rapeseed methyl oleate fermentation product, 0.14 part of jojoba wax PEG-120 esters, 0.034 part of tetrahydropyrimidine carboxylic acid, 0.23 part of a mixture of octanoyl hydroxamic acid, 1, 2-hexanediol, ethylhexyl glycerol and propylene glycol, and the balance of water.
3. The micro essence lotion is characterized by comprising, by weight, 100 parts of p-hydroxyacetophenone, 0.3 part of trehalose, 0.03 part of sodium hyaluronate, 0.07 part of soluble collagen, 0.05 part of disodium edentate, 0.4 part of dipotassium glycyrrhizinate, 0.015 part of aloe vera leaf extract, 0.015 part of candida/glucose/rapeseed methyl oleate fermentation product, 0.14 part of jojoba wax PEG-120 esters, 0.04 part of tetrahydropyrimidine carboxylic acid, 0.23 part of a mixture of octanoyl hydroxamic acid, 1, 2-hexanediol, ethylhexyl glycerol and propylene glycol, and the balance of water.
4. A process for the preparation of a micro-serum according to any one of claims 1 to 3, characterized in that it comprises at least the steps of:
(1) Adding p-hydroxyacetophenone and water into a container at 50 ℃ to obtain a mixture A;
(2) And (3) cooling the mixture in the container in the step (1) to 40 ℃, adding trehalose, sodium hyaluronate, soluble collagen, disodium ethylenediamine tetraacetate, dipotassium glycyrrhizinate, aloe vera leaf extract, candida/glucose/rapeseed methyl oleate fermentation product, jojoba wax PEG-120 esters, tetrahydropyrimidine carboxylic acid, octanoyl hydroxamic acid, 1, 2-hexanediol, ethylhexyl glycerol and propylene glycol, and filtering and checking to be qualified.
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| CN104382833A (en) * | 2014-10-28 | 2015-03-04 | 广东碧嫄化妆品有限公司 | Vegetable protein peptide stock solution as well as preparation method and application thereof |
| CN105456141A (en) * | 2015-12-31 | 2016-04-06 | 天津达仁堂京万红药业有限公司 | Hydrating and nourishing mask and preparing method thereof |
| CN109528593A (en) * | 2018-12-31 | 2019-03-29 | 广州御艾化妆品有限公司 | Facial mask essence and preparation method thereof is repaired in a kind of moisturizing moisturizing |
| CN110115692A (en) * | 2019-05-29 | 2019-08-13 | 华熙生物科技股份有限公司 | A kind of skin care compositions and its application containing glabridin and Ectoin |
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2021
- 2021-08-09 CN CN202110908758.5A patent/CN115068362B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104382833A (en) * | 2014-10-28 | 2015-03-04 | 广东碧嫄化妆品有限公司 | Vegetable protein peptide stock solution as well as preparation method and application thereof |
| CN105456141A (en) * | 2015-12-31 | 2016-04-06 | 天津达仁堂京万红药业有限公司 | Hydrating and nourishing mask and preparing method thereof |
| CN109528593A (en) * | 2018-12-31 | 2019-03-29 | 广州御艾化妆品有限公司 | Facial mask essence and preparation method thereof is repaired in a kind of moisturizing moisturizing |
| CN110115692A (en) * | 2019-05-29 | 2019-08-13 | 华熙生物科技股份有限公司 | A kind of skin care compositions and its application containing glabridin and Ectoin |
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| CN115068362A (en) | 2022-09-20 |
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