CN104382833A - Vegetable protein peptide stock solution as well as preparation method and application thereof - Google Patents
Vegetable protein peptide stock solution as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a vegetable protein peptide stock solution with body firming, repairing, wrinkle resisting and skin quality improving effects as well as a preparation method and application of the vegetable protein peptide stock solution. Active ingredients of the vegetable protein peptide stock solution are from the following raw materials in parts by weight: 1-10 parts of silybum marianum extract, 0.01-0.3 part of carnosine, 0.01-0.2 part of palmitoyl tripeptide-5 and 0.1-3 parts of yeast extract. The invention also discloses a preparation method and application of the vegetable protein peptide stock solution. The prepared vegetable protein peptide stock solution is comprehensively applied to multiple ways for delaying senescence; silybum marianum extract, carnosine, palmitoyl tripeptide-5 and yeast extract are adopted in a specific ratio, and the four substances cooperate mutually to obviously take effects obvious body firming, skin repairing, wrinkle resisting and skin quality improving effects.
Description
Technical field
The present invention relates to cosmetic field, particularly relate to and a kind of there is Firm, reparation, the crease-resistant and plant protein peptide stock solution improving skin quality effect and its preparation method and application.
Background technology
Aging is the only stage which must be passed by any biological life active process; skin is the maximum organ of human body; be responsible for all many-sided effects such as protection, sensation, regulate body temperature, secretion, excretion and immunity; with advancing age; skin also can be aging gradually as other organs of human body, miopragia, forfeiture.Slow down at the skin mesocuticle cell turnover of aging, barrier function weakens, keratinocyte vigor declines, after haveing a superficial wound, repair ability weakens, wherein weakening of barrier function causes xerosis cutis, desquamation, wrinkle, in the skin corium of ageing skin fibroblast quantity reduce gradually, synthesize collagen protein and elastin laminin ability decline, elasticity of skin no longer, become lax.All these changes not only affect skin, also cutaneous adnexa, as hair without brilliance, come off.
In order to overcome these shortcomings, be proposed numerous antidotal cosmetic composition in recent years, these compositionss comprise the chemosynthesis raw material, plant extract, biologically active peptide class raw material etc. that are used alone or in combination.Plant extract is because of its natural, safety in source, and meet the theory of people's " back to nature " and be subject to the high praise of consumer, but active constituent content is limited in plant extraction composition, and be mixed with the impurity such as some metal ions in its extraction component more, along with its increasing of addition in cosmetics series, the more difficult control of stability of cosmetics, thus it is more or less restricted in application.To have action target spot clear and definite because of it for biologically active peptide class raw material, safety is high, side effect is little, add and namely have the advantages such as positive effect on a small quantity, the application in various cosmetics is more and more general, but the less stable of bioactive peptide raw material itself, the easily inactivation by various enzyme or extraneous factor impact, cause its cost of storage higher, and its peptide class cost of material is relatively expensive, is difficult to the needs meeting consuming public.In addition, skin aging is multi-level, a many-sided complex process, and the anti-ageing mechanism of most anti-aging cosmetics foundation is single, is difficult to the needs meeting old and feeble skin.In order to overcome this defect, fractionated cosmetic technical staff makes an addition in cosmetics series in conjunction with the advantageous combination of plant extract and biologically active peptide class raw material, but the cosmetics that major part is added with plant extract and biologically active peptide class raw material mostly in the market are single or the simple combination of various plants extract and biologically active peptide simultaneously, they ignore the interaction relationship not between homopolypeptide class and between polypeptide class and non-protein composition, cause its action effect and not obvious, even poorer than effect when being used alone.
For this reason, many scientific researchers both domestic and external have done large quantity research for the interaction between bioactive peptide and non-protein composition, research finds there is mutually collaborative effect between bioactive peptide and non-protein composition, but also all there is this between not all bioactive peptide and non-protein composition and act on.At present this type of research focuses mostly between little peptide and aldehydes matter or ascorbic acid material, is short of to some extent the research between little peptide and other plant extract, and to mixing ratio between the two more without concrete research.
Summary of the invention
Based on this, the invention provides and a kind of there is Firm, reparation, crease-resistant, the plant protein peptide stock solution of improving skin quality effect.
The concrete technical scheme solved the problems of the technologies described above is as follows:
Have Firm, reparation, crease-resistant, a plant protein peptide stock solution of improving skin quality effect, the active component of described plant protein peptide stock solution comprises the raw material of following weight parts: Herba Silybi mariani extract 1-10 part, carnosine 0.01-0.3 part, palmityl tripeptides-50.01-0.2 part, yeast extract 0.1-3 part.
Wherein in some embodiments, the active component of described plant protein peptide stock solution comprises the raw material of following weight parts: Herba Silybi mariani extract 2-8 part, carnosine 0.02-0.2 part, palmityl tripeptides-50.02-0.1 part, yeast extract 0.2-2 part.
Wherein in some embodiments, the active component of described plant protein peptide stock solution comprises the raw material of following weight parts: Herba Silybi mariani extract 5-7 part, carnosine 0.11-0.13 part, palmityl tripeptides-50.05-0.07 part, yeast extract 0.9-1.1 part.
Another object of the present invention is to provide a kind of above-mentioned preparation method with Firm, reparation, crease-resistant, the plant protein peptide stock solution of improving skin quality effect, it comprises the following steps:
(1) carnosine, palmityl tripeptides-5 and yeast extract are mixed, obtain mixture, add mannitol, and be dissolved in phosphate buffer, obtain liquid I; The weight of described mixture, mannitol and phosphate buffer is 0.9-1.1:0.9-1.1:0.9-1.1; The pH of described phthalate buffer is 6.7-6.9;
(2) get Herba Silybi mariani extract, be dissolved in hot acetone, the solid-liquid ratio g/ml of Herba Silybi mariani extract and hot acetone liquid is 1:25-35, in 35-55 DEG C of insulation, obtains liquid II;
(3) liquid I is mixed with liquid II, add lecithin, stir 30-90min, add the normal hexane with acetone equivalent after the vacuum concentration to the 1/5-1/6 of original volume of concussion limit, limit, filter after 20-30min, get supernatant liquid, to obtain final product; The addition of described lecithin is 2-3 times of Herba Silybi mariani extract weight.
Another object of the present invention is to provide above-mentioned plant protein peptide stock solution to have Firm, reparation, crease-resistant, the application improved in the cosmetics of skin quality effect in preparation.
Another object of the present invention is to provide a kind of cosmetics, what described cosmetics included 1-13wt% above-mentioned has Firm, reparation, crease-resistant, the plant protein peptide stock solution of improving skin quality effect.
Another object of the present invention is to provide a kind of essence, described essence comprises the component of following weight percentage ratio:
Plant protein peptide stock solution: 1-13wt%,
1,3-PD: 2-6wt%,
Glycerol: 2-6wt%,
Hyaluronate sodium: 0.05-0.1wt%,
Carbomer: 0.1-0.2wt%,
Xanthan gum: 0.1-0.3wt%,
Methyl hydroxybenzoate: 0.1-0.2wt%,
Sodium hydroxide: 0.01-0.04wt%,
Trehalose: 1-4wt%,
Oligofructose: 0.5-2wt%,
Euglena gracilis polysaccharide and/or hydrolytic collagen: 0.1-0.35wt%,
Aloe vulgaris leaf extract: 0.5-2wt%,
Glycerol polymethacrylates and/or propylene glycol and/or PVM/M copolymer: 1-3wt%,
Ovshinsky Sargassum extract: 1-3wt%,
Pantothenylol: 0.1-0.9wt%,
Laurocapram: 0.1-0.8wt%,
Six peptide-9/1,3-butanediol: 0.1-1wt%,
L-is anti-ruins hematic acid-2-glucoside: 1-3wt%,
Dipeptides-4:0.02-0.07wt%,
Citric acid: 0.01-0.03wt%,
Sodium citrate: 0.1-0.5wt%,
Potassium hydroxide: 0.15-0.55wt%,
Phenoxyethanol: 0.1-0.5wt%,
Methylisothiazolinone and/or iodine propilolic alcohol butyl mephenesin Carbamate: 0.02-0.07wt%,
Deionized water: surplus.
Another object of the present invention is to provide a kind of moisturizer, described moisturizer comprises the component of following weight percentage ratio:
Plant protein peptide stock solution: 1-13wt%,
Methyl sesquistearate: 0.5-2wt%,
PEG-20 methyl sesquistearate: 0.5-2wt%,
Glyceryl stearate and/or PEG-100 stearate: 0.2-0.9wt%,
Hydrogenated jojoba oil: 1-3wt%,
Hydrogenation macadimia nut seed oil: 1-3wt%,
Isononyl isononanoate: 1-3wt%,
Polydimethylsiloxane: 1-3wt%,
Hydrogenated glucose seed oil: 0.2-0.7wt%,
Tocopherol: 0.2-0.8wt%,
Cetearyl alcohol: 1.0-2.5wt%,
Butylated hydroxytoluene: 0.02-0.08wt%,
Laurocapram: 0.5-2wt%,
1,3-PD: 2-6wt%,
Sorbitol: 4-8wt%,
Hyaluronate sodium: 0.03-0.08wt%,
Methyl hydroxybenzoate: 0.05-0.15wt%,
Xanthan gum: 0.06-0.18wt%,
Sodium acrylate/sodium acryloyldimethyl taurate copolymers and/or Polyoxyethylene Sorbitan Monooleate and/or 2-Methylpentadecane: 0.1-0.5wt%,
Nicotiamide: 1-3wt%,
Euglena gracilis polysaccharide and/or hydrolytic collagen: 0.05-0.2wt%,
Beta glucan: 0.05-0.17wt%,
Pantothenylol: 0.06-0.16wt%,
Six peptides-9 and/or butanediol: 0.15-0.75wt%,
Butanediol/water/peony root extractive: 0.1-0.5wt%,
Ovshinsky Sargassum extract: 1-3wt%,
Methylisothiazolinone: 0.01-0.08wt%,
Phenoxyethanol: 0.15-0.45wt%,
L-is anti-ruins hematic acid-2-glucoside: 0.5-2wt%,
Dipeptides-4:0.01-0.08wt%,
Citric acid: 0.006-0.015wt%,
Sodium citrate: 0.05-0.22wt%,
Potassium hydroxide: 0.08-0.215wt%,
Deionized water: surplus.
Another object of the present invention is to provide a kind of late frost, described late frost comprises the component of following weight percentage ratio:
Plant protein peptide stock solution: 1-13wt%,
The smooth olive oil acid esters of cetearyl alcohol olive oil acid esters/Pyrusussuriensis: 1-5wt%,
Spermol cetylate and/or the smooth cetylate of Pyrusussuriensis and/or the smooth olive oil acid esters of Pyrusussuriensis: 1-3wt%,
Cetearyl alcohol: 1-3wt%,
Butyrospermum parkii fruit fat: 0.5-1.5wt%,
Caprylic/capric triglyceride: 1-5wt%,
Dicaprylyl carbonate: 1-5wt%,
Hydrogenated olive oil: 1-3wt%,
Titanium dioxide: 0.2-0.7wt%,
Glyceryl stearate: 0.4-1.0wt%,
Tocopherol (vitamin E): 0.2-1.0wt%,
Polydimethylsiloxane: 0.1-0.5wt%,
Laurocapram: 0.5-1.5wt%,
Hyaluronate sodium: 0.05-0.15wt%,
1,3-PD: 1-6wt%,
Sorbitol: 1-6wt%,
Vinyldimethicone/polymethyl siloxane silsesquioxane cross linked polymer: 0.2-0.8wt%,
Fructus Hordei Germinatus oligose glucoside/hydrogenated starch hydrolysate: 0.3-0.8wt%,
1,2-hexanediol/caprylyl glycol: 0.1-0.7wt%,
Phenoxyethanol and/or Sensiva SC50: 0.1-0.3wt%,
Aloe vulgaris leaf extract: 1-3wt%,
Ovshinsky Sargassum extract: 1-3wt%,
Six peptides-9 and/or butanediol: 0.2-0.8wt%,
Beta glucan: 0.5-1.5wt%,
Euglena gracilis polysaccharide and/or hydrolytic collagen: 0.05-0.15wt%,
L-is anti-ruins hematic acid-2-glucoside: 1-3wt%,
Citric acid: 0.01-0.04wt%,
Sodium citrate: 0.1-0.5wt%,
Potassium hydroxide: 0.12-0.44wt%,
Dipeptides-4:0.02-0.07wt%,
Deionized water: surplus.
Another object of the present invention is to provide a kind of eye cream, described eye cream comprises the component of following weight percentage ratio:
Plant protein peptide stock solution: 1-13wt%,
C14-22 alcohol/C12-20 alkyl androstanediol: 1-2.5wt%,
Glyceryl stearate and/or PEG-100 stearate: 1-2.4wt%,
Cetearyl alcohol: 1.5-3.5wt%,
Laurocapram: 0.5-0.6wt%,
Squalane: 1.0-2.5wt%,
Polydimethylsiloxane: 1-3wt%,
Caprylic/capric triglyceride: 1-2.5wt%,
Butyrospermum parkii fruit fat: 1-3wt%,
Hydrogenated jojoba oil: 1-3wt%,
Methyl hydroxybenzoate: 0.1-0.2wt%,
Propyl hydroxybenzoate: 0.07-0.15wt%,
Hyaluronate sodium: 0.01-0.05wt%,
Xanthan gum: 0.08-0.16wt%,
Glycerol: 1-3wt%,
PEG-8: 3-7wt%,
Polyacrylamide/C13-14 isoparaffin/laureth-7:0.3-0.9wt%,
Polydimethylsiloxane and/or dimethiconol: 0.2-0.7wt%,
Butanediol: 1-2wt%,
Six peptides-9 and/or butanediol: 0.2-0.8wt%,
Aloe vulgaris leaf extract: 0.5-1.5wt%,
Ovshinsky Sargassum extract: 0.5-1.5wt%,
Diazolidinyl urea and/or iodine propilolic alcohol butyl mephenesin Carbamate: 0.2-0.8wt%,
Methylisothiazolinone: 0.01-0.08wt%,
Phenoxyethanol: 0.1-0.35wt%,
L-is anti-ruins hematic acid-2-glucoside: 1-3wt%,
Dipeptides-4:0.01-0.08wt%,
Acetyl tetrapeptide-5:0.05-0.18wt%,
Citric acid: 0.01-0.05wt%,
Sodium citrate: 0.1-0.5wt%,
Potassium hydroxide: 0.15-0.45wt%,
Deionized water: surplus.
Another object of the present invention is to provide a kind of and repair stock solution, described reparation stock solution comprises the component of following weight percentage ratio:
Plant protein peptide stock solution: 1-13wt%,
Carbomer: 0.1-0.32wt%,
Hyaluronate sodium: 0.15-0.5wt%,
Sodium polyacrylate/Polyethylene Glycol-5M:0.01-0.04wt%,
Butanediol: 0.5-2wt%,
Triethanolamine: 0.1-0.32wt%,
Euglena gracilis polysaccharide and/or hydrolytic collagen: 0.06-0.16wt%,
Acetyl group six peptide-7:1-3wt%,
Seaweed extracted liquor: 0.5-1.5wt%,
Hamamelis virginiana extract: 0.5-1.5wt%,
Phenoxyethanol: 0.15-0.35wt%,
Methylisothiazolinone and/or iodine propilolic alcohol butyl mephenesin Carbamate: 0.02-0.07wt%,
Deionized water: surplus.
Title described in above components of cosmetics is the title of international cosmetic raw material name (InterntionlNomenclture Cosmetic Ingredient, INCI) defined, as: Euglena gracilis polysaccharide, hydrolytic collagen, glycerol polymethacrylates, propylene glycol, PVM/M copolymer, six peptide-9/1,3-butanediols, Methylisothiazolinone, iodine propilolic alcohol butyl mephenesin Carbamate, glyceryl stearate, PEG-100 stearate, sodium acrylate/sodium acryloyldimethyl taurate copolymers, Polyoxyethylene Sorbitan Monooleate, 2-Methylpentadecane, six peptides-9, butanediol, butanediol/water/peony root extractive, the smooth olive oil acid esters of cetearyl alcohol olive oil acid esters/Pyrusussuriensis, spermol cetylate, the smooth cetylate of Pyrusussuriensis, the smooth olive oil acid esters of Pyrusussuriensis, caprylic/capric triglyceride, vinyldimethicone/polymethyl siloxane silsesquioxane cross linked polymer, Fructus Hordei Germinatus oligose glucoside/hydrogenated starch hydrolysate, 1,2-hexanediol/caprylyl glycol, phenoxyethanol, Sensiva SC50, C14-22 alcohol/C12-20 alkyl androstanediol, polyacrylamide/C13-14 isoparaffin/laureth-7, polydimethylsiloxane, dimethiconol, diazolidinyl urea, iodine propilolic alcohol butyl mephenesin Carbamate, sodium polyacrylate/Polyethylene Glycol-5M, Methylisothiazolinone, iodine propilolic alcohol butyl mephenesin Carbamate.
Plant protein peptide stock solution of the present invention refers to the compositions of plant extract component and polypeptide, and its action principle is as follows:
Relevant skin Aging Mechanism theory is numerous, wherein representative free radical causes of senescence thinks that producing the dynamic equilibrium that too much free radical breaks interior free yl in human body is cause old and feeble key factor, when the dynamic equilibrium self of the free radical in body cannot balance, the Function of Antioxidant System supplementing certain level in some natural safe antioxidants maintenance bodies can delay body aging.Nonenzymatic glycosylation causes of senescence thinks that saccharifying is the one of the main reasons of skin aging, when body cannot to remove in blood free unnecessary sugar, supplements some natural safe anti-gfycation agent and suppresses the generation of glycosylations can slow down aging.Another skin aging theory-matrix metalloproteinase theory thinks that secretion of matrix metalloproteinases increase can make intracellular collagen protein degradation increase in body, supplements some and the inhibitor of matrix metal proteinase activity can be suppressed can to reduce the generation of wrinkle.
Herba Silybi mariani extract is the natural extract of active constituent content more than 80% extracted from Compositae Silybum herbaceous plant Herba Silybi mariani seed, the main chemical composition silymarin that Herba Silybi mariani contains can not only suppress the multiple free radicals such as oxygen-derived free radicals, hydroperoxides free radical, hydroxy radical, it is good antioxidant, and its to the suppression ratio of elastoser up to about 82%, degraded and the loss of collagen protein and elastin laminin can be reduced from root.In addition, Herba Silybi mariani extract all has inhibitory action to tryrosinase and melanocyte.
Carnosine is and β-dipeptides of alanyl-L-histidin composition, and carnosine is proved to be potent antioxidant, can effective quenching activity oxygen-derived free radicals, Cell protection film; Carnosine can suppress saccharification react as good anti-gfycation agent, effective cancellation carbonyl radical, collagen protein etc. can also be prevented macromolecular crosslinked, reduce the generation of wrinkle; The part that carnosine forms as skin, natural, safety, can help impaired skin tissue to repair, and improves the immunocompetence of skin; Carnosine heavy metal ion has complexing, not only can play the effect of dispelling toxicity, detoxicating, for contributing to the stability maintaining formula in cosmetics series.
Palmityl tripeptides-5 can be skin replenishing collagen, promotes its elasticity, significantly reduces face wrinkle; Skin water content can be improved, recover smooth and compact, improve the colour of skin, strengthen gloss and transparency.
Yeast extract contains the nutritional labelings such as aminoacid, polypeptide, nucleic acid, vitamin, mineral, and aminoacid is the main component of nature moisturizing factor in keratodermatitis (NMF), is easily absorbed by the skin, excellent moistening effect; Small-molecular peptides improves significantly to skin lines; Nucleic acid and nucleotide are the central genetic materials of human body, there is enhancing metabolism, improve the effects such as protein synthesis speed, strengthen immune function, enhance SOD activity, improve the merits such as skin antiradical activities, microgroove, corse sweat pore etc. dark yellow to skin improve obviously; The nutrient such as vitamin and mineral can provide sufficient nutrition for skin.
In forefathers' research, inventor recognizes between peptide and peptide and both there is mutually collaborative effect between peptide and non-protein composition also there is antagonism, and this relation is by the impact of the factors such as the proportion relation of mixture and formula system.The present inventor passes through Herba Silybi mariani extract, carnosine, palmityl tripeptides-5 and yeast extract carry out studying discovery by four according to the plant protein peptide stock solution oxidation resistance obtained under the synergism of four kinds of compositions after weight mixing of the present invention, skin elasticity and wrinkle improve ability and significantly improve, this plant protein peptide stock solution is applied in all kinds of cosmetics provided by the invention and can plays significant Firm, repair, crease-resistant, improve effect of skin quality, its successful is higher than adding Herba Silybi mariani extract separately, carnosine, palmityl tripeptides-5, yeast extract or four kinds of components are with the mixture of other ratio simple combination outside the present invention.
Of the present invention a kind ofly have Firm, reparation, the crease-resistant and plant protein peptide stock solution improving skin quality effect and its preparation method and application and have the following advantages and beneficial effect:
(1) the present invention is through a large amount of experiment of inventor and research, draw that there is significant Firm, reparation, crease-resistant, the plant protein peptide stock solution of improving skin quality effect, determine best composition and the proportioning thereof of described plant protein peptide stock solution, by Herba Silybi mariani extract, yeast extract, carnosine, palmityl tripeptides-5 with special ratios with the use of, can work in coordination with produce significant Firm, reparation, crease-resistant, improve skin quality effect; In addition, obtained thing protein peptide stock solution also have easily be absorbed by the skin, advantage that bioavailability is high;
(2) approach of the multiple slow down aging of plant protein peptide stock solution of the present invention integrated application, effective raising scavenging free radicals and suppression skin glycosylation ability, degraded and the loss of collagen protein and elastin laminin is lacked from root, the aging of delaying skin, so have significant Firm, reparation, crease-resistant, improve skin quality effect;
(3) preparation method of plant protein peptide stock solution of the present invention is simple to operation, is applicable to large-scale production.
Detailed description of the invention
Below with reference to specific embodiment, the present invention will be further described.
In following embodiment, Herba Silybi mariani extract is purchased from Yangzhou Kang Mei Bioisystech Co., Ltd; Carnosine is purchased from Ren Bang bio tech ltd, Xi'an; Palmityl tripeptides-5 is purchased from Quan Wang bio tech ltd, Shanghai; Yeast extract is purchased from You Ran bio tech ltd, Guangzhou; Lecithin and soybean phospholipid are purchased from US business's trade company limited in Henan, Henan; Phosphate buffer is purchased from Ke Tianhua glass Instrument Ltd. of Shenzhen; Other are commercially available prod.
" phenoxyethanol, Sensiva SC50 " described in following embodiment refers to the mixture of phenoxyethanol and Sensiva SC50, purchased from Galaxy Surfactants Ltd; " six peptides-9, butanediol " refers to the mixture of six peptides-9 and butanediol, purchased from You Ran bio tech ltd, Guangzhou; " Euglena gracilis polysaccharide, hydrolytic collagen " refers to the mixture of Euglena gracilis polysaccharide and hydrolytic collagen, purchased from Bio-Nest BiochemicalTechnology; " glyceryl stearate, PEG-100 stearate " refers to the mixture of glyceryl stearate and PEG-100 stearate, purchased from Croda Singapore Pte Ltd; " polydimethylsiloxane, dimethiconol " refers to the mixture of polydimethylsiloxane and dimethiconol, purchased from Guangzhou Hua Ke organosilicon company limited; " diazolidinyl urea, iodine propilolic alcohol butyl mephenesin Carbamate " refers to the mixture of diazolidinyl urea and iodine propilolic alcohol butyl mephenesin Carbamate, purchased from ISP ChemicalsLLC; " glycerol polymethacrylates, propylene glycol, Gantrez AN-119 " refers to the mixture of glycerol polymethacrylates, propylene glycol and Gantrez AN-119, purchased from ISP TECHNOLOGIESINC; " Methylisothiazolinone, iodine propilolic alcohol butyl mephenesin Carbamate " refers to the mixture of Methylisothiazolinone and iodine propilolic alcohol butyl mephenesin Carbamate, purchased from Guangzhou Ao Xue Chemical Co., Ltd.; " sodium acrylate/sodium acryloyldimethyl taurate copolymers, Polyoxyethylene Sorbitan Monooleate, 2-Methylpentadecane " refers to the mixture of sodium acrylate/sodium acryloyldimethyl taurate copolymers, Polyoxyethylene Sorbitan Monooleate and 2-Methylpentadecane, purchased from Guangzhou hundred Hao Bo company limited; " the smooth cetylate of spermol cetylate, Pyrusussuriensis, Pyrusussuriensis smooth olive oil acid esters " refers to the mixture of the smooth cetylate of spermol cetylate, Pyrusussuriensis and the smooth olive oil acid esters of Pyrusussuriensis, above-mentioned each mixture is commercially available prod, purchased from Guangzhou chin or cheek and trade Co., Ltd.
Embodiment 1
A kind of plant protein peptide stock solution of the present embodiment, its active component comprises the raw material of following weight:
Herba Silybi mariani extract 1g, carnosine 0.01g, palmityl tripeptides-50.01g, yeast extract 0.1g.
The preparation method of above-mentioned a kind of plant protein peptide stock solution, comprises the following steps:
(1) get 0.01g carnosine, 0.01g palmityl tripeptides-5, the mixing of 0.1g yeast extract, add 0.12g mannitol, be dissolved in 0.12g phosphate buffer (pH6.8), obtain liquid I;
(2) get 1g Herba Silybi mariani extract, be dissolved in 25ml hot acetone, 35 DEG C of insulations, obtain liquid II;
(3) liquid I is mixed with liquid II, add 2g lecithin, stir 30min, add 25ml normal hexane after the vacuum concentration to 1/5 of original volume of concussion limit, limit, filter after 20min, collect supernatant liquid and be plant protein peptide stock solution of the present invention.
Embodiment 2
A kind of plant protein peptide stock solution of the present embodiment, its active component comprises the raw material of following weight:
Herba Silybi mariani extract 2g, carnosine 0.02g, palmityl tripeptides-50.02g, yeast extract 0.2g.
The preparation method of above-mentioned a kind of plant protein peptide stock solution, comprises the following steps:
(1) get 0.02g carnosine, 0.02g palmityl tripeptides-5, the mixing of 0.2g yeast extract, add 0.24g mannitol, be dissolved in 0.24g phosphate buffer (pH6.8), obtain liquid I;
(2) take 2g Herba Silybi mariani extract, be dissolved in 60ml hot acetone, 45 DEG C of insulations, obtain liquid II;
(3) liquid I is mixed with liquid II, add 6g lecithin, stir 60min, add 60ml normal hexane after the vacuum concentration to 1/6 of original volume of concussion limit, limit, filter after 25min, collect supernatant liquid and be plant protein peptide stock solution of the present invention.
Embodiment 3
A kind of plant protein peptide stock solution of the present embodiment, its active component comprises the raw material of following weight:
Herba Silybi mariani extract 6g, carnosine 0.12g, palmityl tripeptides-50.06g, yeast extract 1g.
The preparation method of above-mentioned a kind of plant protein peptide stock solution, comprises the following steps:
(1) get 0.12g carnosine, 0.06g palmityl tripeptides-5, the mixing of 1g yeast extract, add 1.18g mannitol, be dissolved in 1.18g phosphate buffer (pH6.8), obtain liquid I;
(2) take 6g Herba Silybi mariani extract, be dissolved in 180ml hot acetone, 45 DEG C of insulations, obtain liquid II;
(3) liquid I is mixed with liquid II, add 12g lecithin, stir 60min, add 180ml normal hexane after the vacuum concentration to 1/5 of original volume of concussion limit, limit, filter after 25min, collect supernatant liquid and be plant protein peptide stock solution of the present invention.
Embodiment 4
A kind of plant protein peptide stock solution of the present embodiment, its active component comprises the raw material of following weight:
Herba Silybi mariani extract 8g, carnosine 0.2g, palmityl tripeptides-50.1g, yeast extract 2g.
The preparation method of above-mentioned a kind of plant protein peptide stock solution, comprises the following steps:
(1) get 0.2g carnosine, 0.1g palmityl tripeptides-5, the mixing of 2g yeast extract, add 2.3g mannitol, be dissolved in 2.3g phosphate buffer (pH6.8), obtain liquid I;
(2) take 8g Herba Silybi mariani extract, be dissolved in 240ml hot acetone, 45 DEG C of insulations, obtain liquid II;
(3) liquid I is mixed with liquid II, add 16g lecithin, stir 60min, add 240ml normal hexane after the vacuum concentration to 1/6 of original volume of concussion limit, limit, filter after 25min, collect supernatant liquid and be plant protein peptide stock solution of the present invention.
Embodiment 5
A kind of plant protein peptide stock solution of the present embodiment, its active component comprises the raw material of following weight:
Herba Silybi mariani extract 10g, carnosine 0.3g, palmityl tripeptides-50.2g, yeast extract 3g.
The preparation method of above-mentioned a kind of plant protein peptide stock solution, comprises the following steps:
(1) get 0.3g carnosine, 0.2g palmityl tripeptides-5, the mixing of 3g yeast extract, add 3.5g mannitol, be dissolved in 3.5g phosphate buffer (pH6.8), obtain liquid I;
(2) take 10g Herba Silybi mariani extract, be dissolved in 350ml hot acetone, 55 DEG C of insulations, obtain liquid II;
(3) liquid I is mixed with liquid II, add 30g lecithin, stir 90min, add 350ml normal hexane after the vacuum concentration to 1/5 of original volume of concussion limit, limit, filter after 30min, collect supernatant liquid and be plant protein peptide stock solution of the present invention.
Comparative example 1
A kind of plant protein peptide stock solution of this comparative example, its active component comprises the raw material of following weight:
Herba Silybi mariani extract 1.1g, carnosine 0.006g, palmityl tripeptides-50.006g, yeast extract 0.05g.
The preparation method of above-mentioned a kind of plant protein peptide stock solution, comprises the following steps:
(1) get 0.006g carnosine, 0.006g palmityl tripeptides-5, the mixing of 0.05g yeast extract, add 0.062g mannitol, be dissolved in 0.062g phosphate buffer (pH6.8), obtain liquid I;
(2) take 1.1g Herba Silybi mariani extract, be dissolved in 27.5ml hot acetone, 35 DEG C of insulations, obtain liquid II;
(3) liquid I is mixed with liquid II, add 2.2g lecithin, stir 30min, add 27.5ml normal hexane after the vacuum concentration to 1/5 of original volume of concussion limit, limit, filter after 20min, collect supernatant liquid and namely obtain compositions A.
Comparative example 2
A kind of plant protein peptide stock solution of this comparative example, its active component comprises the raw material of following weight:
Herba Silybi mariani extract 11g, carnosine 3.5g, palmityl tripeptides-52.5g, yeast extract 4g.
The preparation method of above-mentioned a kind of plant protein peptide stock solution, comprises the following steps:
(1) get 3.5g carnosine, 2.5g palmityl tripeptides-5, the mixing of 4g yeast extract, add 10g mannitol, be dissolved in 10g phosphate buffer (pH6.8), obtain liquid I;
(2) take 11g Herba Silybi mariani extract, be dissolved in 385ml hot acetone, 55 DEG C of insulations, obtain liquid II;
(3) liquid I is mixed with liquid II, add 33g lecithin, stir 90min, add 385ml normal hexane after the vacuum concentration to 1/5 of original volume of concussion limit, limit, filter after 30min, collect supernatant liquid and namely obtain compositions B.
Embodiment 6
Plant protein peptide stock solution obtained by embodiment 1 and the compositions A obtained by comparative example 1 are made late frost, and a1, b1, c1 group is containing the plant protein peptide stock solution obtained by embodiment 1, and a2 group is containing the compositions A obtained by comparative example 1, and a3 group is blank group.
The component of a1-c1 group and a2, b2 group late frost and content thereof are in table 1:
The composition of table 1 late frost and percentage by weight thereof
Embodiment 7
Get 2g Herba Silybi mariani extract, 0.02g carnosine, 0.02g palmityl tripeptides-5,0.2g yeast extract mix homogeneously obtain mixture C.
Plant protein peptide stock solution obtained by embodiment 2 is prepared into eye cream, and d1, e1, f1 group is containing the plant protein peptide stock solution obtained by embodiment 2, and d2 group is blank group containing mixture C, d3 group.
The component of d1-f1 group and d2, d3 group eye cream and percetage by weight thereof are in table 2:
The component of table 2 eye cream and percetage by weight thereof
Embodiment 8
Get 6g Herba Silybi mariani extract, 0.12g carnosine, 0.06g palmityl tripeptides-5,1g yeast extract mix homogeneously obtain mixture D.
Plant protein peptide stock solution obtained by embodiment 3 is prepared into essence, and g1, h1, i1 group is containing the plant protein peptide stock solution obtained by embodiment 3, and g2 group is blank group containing mixture D, g3 group.
The component of g1-i1 group and g2, g3 group essence and percetage by weight thereof are in table 3:
The component of table 3 essence and percetage by weight thereof
Embodiment 9
Get 8g Herba Silybi mariani extract, 0.2g carnosine, 0.1g palmityl tripeptides-5,2g yeast extract mix homogeneously obtain mixture E.
Plant protein peptide stock solution obtained by embodiment 4 is prepared into reparation stock solution, and j1, k1, l1 group is containing the plant protein peptide stock solution obtained by embodiment 4, and j2 group is blank group containing mixture E, j3 group.
The component of j1-l1 group and j2, j3 group reparation stock solution and percetage by weight thereof are in table 4:
Table 4 repairs component and the percetage by weight thereof of stock solution
Embodiment 10
Plant protein peptide stock solution obtained by embodiment 5 is prepared into moisturizer, and m1, n1, o1 group is containing the plant protein peptide stock solution obtained by embodiment 5, and m2 group is blank group containing the compositions B obtained by comparative example 2, m3 group.
The component of m1-o1 group and m2, m3 group moisturizer and percetage by weight thereof are in table 5:
The component of table 5 moisturizer and percetage by weight thereof
Embodiment 11 safety evaluatio
One, experiment purpose
By the safety of the cosmetics obtained by relative analysis Evaluation operation example 6-10.
Two, experimental technique---repeatedly irritation test
(1) test specimen: the c1 group late frost obtained by embodiment 6 ~ 10 formula, f1 group eye cream, i1 group essence, l1 group repair stock solution and o1 group moisturizer;
(2) experimental animal: the adult white new zealand rabbit of health, skin zero damage, regular grade, totally 20, body weight is 2.3-2.5kg, thered is provided (animal productiong credit number: SCXK (Guangdong) 2003-0002) by Guangdong Medical Lab Animal Center, the experimental animal quality certification is numbered: 0003286, laboratory animal occupancy permit number: SYXK (Guangdong) 2003-0011, the temperature of Animal House is 20 ~ 24 DEG C, humidity is 40% ~ 66%RH, drinking water is tap water, carries out random packet before experiment, often organizes 4;
(3) test procedure:
1. cut by hair spinal column both sides, laboratory animal back before test, unhairing scope is respectively 3cmX3cm, application area 2.5cmX2.5cm;
2. about O.5g get test specimen spreads upon on the skin of side, and opposite side smears equivalent distilled water as blank, smears 1 every day, smears 14 days continuously.From second day, smear front cropping at every turn, remain tested material with water or nonirritant solvent cleaning, observed result after a hour.
Three, experimental result
Require to evaluate experimental result with reference to " cosmetics health specification " (version in 2007) " skin irritation/corrosivity ", repeatedly skin irritation test result is as shown in the table for c1 group late frost, f1 group eye cream, i1 group essence, l1 group reparation stock solution and o1 group moisturizer:
Table 6 c1 group late frost repeatedly skin irritation test result
As known from Table 6: in experimentation, have no other toxic reactions, f1 group eye cream, i1 group essence, l1 group repair stock solution and o1 group moisturizer repeatedly skin irritation test result and c1 group late frost repeatedly skin irritation test result is consistent, detailed data can see table 6, prove thus plant protein peptide stock solution of the present invention and cosmetics provided by the invention comparatively safe non-stimulated.
Embodiment 12 efficacy assessments
One, experiment purpose
Evaluated by relative analysis, the cosmetics Firm of Evaluation operation example obtained by 6-10, reparation, crease-resistant, effect of improving skin quality.
Two, experimental technique
1, clinical experiment evaluation
Collection female volunteers 180 people, be divided into 6 groups at random, often organize 30 people, 46.2 years old mean age, experimenter is healthy, without hereditary or passing medical history, without bad life habits etc.Repair stock solution and m1, m2, m3 group moisturizer product carry out observation of curative effect for a1, a2, a3 group late frost, d1, d2, d3 group eye cream, g1, g2, g3 group essence, j1, j2, j3 group, observation trier before testing and test area skin moisture, elasticity, microgroove, roughness, glossiness situation in test process.
2, experimental technique
Using a1, d1, g1, j1 and m1 set product as experiment product, be corresponding reference substance with a2, a3, d2, d3, g2, g3, j2, j3, m2, m3 set product and certain commercially available defying age essence, in the experimenter left and right sides, experiment product and reference substance are smeared respectively as Experimental Area in the region of selected about 5 × 5cm size, applying amount is about 5g, before smearing sample, experimenter uses identical gentle cleaning agent to clean face, sooner or later respectively once, 8 weeks are used continuously.
3, evaluation methodology
Experimenter's skin moisture and elastic improvement situation utilize skin moisture test apparatus (CorneometerCM820) and skin elasticity analyzer (Cutoceter SEM575) to measure, and trier before testing pilot region initial skin moisture content value and elasticity number is designated as M respectively
0, N
0, each test zone respectively detects 5 times, obtains the meansigma methods of this time period 5 M, N.In order to better evaluate moisture and the photoelastic evaluation data of gained, by average M, N value of detecting at every turn respectively divided by pilot region skin moisture content and elasticity meansigma methods M before testing
0, N
0obtain moisture grading R and the elasticity grading S at this position, grade S value of moisture grading R value and elasticity is larger, illustrate product increase moisture content of skin and elastic effect more obvious.
Three, experimental result
Experimental result is as following table:
Table 7 moisture content of skin measured value
Table 8 skin elasticity measured value
Table 9 skin lines, roughness, glossiness improve end value
Irritative response and other toxic reactions is showed no in trier's clinical trial process.
Interpretation of result: can a1 be found out from above table 7-9, a2, a3 group late frost, d1, d2, d3 group eye cream, g1, g2, g3 group essence, j1, j2, j3 group repairs stock solution and m1, m2, m3 group moisturizer product and certain commercially available essence are to skin moisture content, elasticity, microgroove, roughness, glossiness all has improvement result in various degree, but with the addition of the product of the plant protein peptide stock solution by embodiment 1-5 proportioning: a1 group late frost, d1 group eye cream, g1 group essence, j1 group reparation stock solution and m1 group moisturizer are to skin moisture content, elasticity, microgroove, roughness, glossiness is improved effect and is presented increasing trend respectively, effect is all significantly better than reference product, and with the addition of the g1 group essence most pronounced effects of the plant protein peptide stock solution obtained according to embodiment 3 component proportion, no matter evaluate from effect aspect or cost control aspect, illustrate that in the plant protein peptide stock solution described in embodiment 3, each component proportion is best proportioning value, can find out that it improves effect and reference substance a3 group no significant difference to skin moisture content, elasticity, microgroove, roughness, glossiness from reference substance a2 group data, and the effect of reference substance m2 group has the trend of successively decreasing on the contrary, it can be said that and adopt specific proportioning between each component of bright plant protein peptide stock solution of the present invention, create synergism, have significant Firm, reparation, crease-resistant, improve skin quality effect, in addition, the improvement successful of reference substance d2, g2, j2 set product is weaker than corresponding trial target d1, g1, j1 set product, illustrate that the plant protein peptide stock solution by preparation method of the present invention is obtained can better be absorbed by the skin thus, improve its bioavailability.
Embodiment 13
One, experiment purpose
The ABTS of plant protein peptide stock solution of the present invention is evaluated by relative analysis
+radical scavenging activity.
Two, experimental technique
1, laboratory sample
(1) 0.12g carnosine;
(2) 0.06g palmityl tripeptides-5;
(3) 1g yeast extract;
(4) 6g Herba Silybi mariani extract;
(5) mixture of 0.01g carnosine, 0.01g palmityl tripeptides-5,0.1g yeast extract, 1g Herba Silybi mariani extract;
(6) mixture of 0.02g carnosine, 0.02g palmityl tripeptides-5,0.2g yeast extract, 2g Herba Silybi mariani extract;
(7) mixture of 0.12g carnosine, 0.06g palmityl tripeptides-5,1g yeast extract, 6g Herba Silybi mariani extract;
(8) mixture of 0.2g carnosine, 0.1g palmityl tripeptides-5,2g yeast extract, 8g Herba Silybi mariani extract;
(9) mixture of 0.3g carnosine, 0.2g palmityl tripeptides-5,2g yeast extract, 10g Herba Silybi mariani extract;
(10) mixture of 0.006g carnosine, 0.006g palmityl tripeptides-5,0.05g yeast extract, 1.1g Herba Silybi mariani extract;
(11) mixture of 3.5g carnosine, 2.5g palmityl tripeptides-5,4g yeast extract, 11g Herba Silybi mariani extract.
2, ABTS
+the configuration of free radical storing solution
Configuration ABTS
+free radical storing solution makes ABTS
+be respectively 7mmol/L and 2.45mmol/L with the final concentration of potassium persulfate, place 16 hours under room temperature, lucifuge condition, form ABTS
+storing solution.(storing solution dilution is working solution by (pH7.4), makes its light absorption value at 734nm place be 0.70 ± 0.02 to use 0.1M phosphate buffer.
3, the mensuration of radical scavenging activity
Get above-mentioned sample and the Trolox solution of equivalent, be configured to the solution of 0.01mg/ml, get 0.1ml sample solution or Trolox solution and 3.9mlABTS respectively
+working solution mixes, and after water-bath 30 DEG C reaction 6min, read light absorption value at 734nm, the concentration of selected sample makes the ABTS of sample
+clearance rate is within the scope of 20-80%.Measure the ABTS of same concentrations BHA
+scavenging activity is made comparisons.
ABTS
+radical scavenging activity evaluation result
ABTS in experimental result
+scavenging activity Trolox oxidation resistance of equal value (TEAL Troloxequivalent antioxidant capacity, μM) represents.
Or be expressed as: ABTS
+scavenging activity (mmolTEAC/100g)=TEAC
sample/ 10C
sample
TEAC in formula
samplerepresent the Trolox concentration that sample is of equal value in mark song, unit is a μm ol/L; C
samplerepresent sample concentration, unit is mg/ml; 10 is the natural number in unit computing.
Three, experimental result
Experimental result sees table 10:
Table 10 each sample ABTS
+radical scavenging activity compares (P<0.05)
| Sample number into spectrum | ABTS +·Scavenging activity (unit: mmolTEAC/100gDW) |
| (1) | 4.14±0.02 |
| (2) | 0.42±0.03 |
| (3) | 71.5±1.3 |
| (4) | 276.8±8.2 |
| (5) | 345.6±4.6 |
| (6) | 384.8±4.4 |
| (7) | 541.7±5.1 |
| (8) | 533.2±4.9 |
| (9) | 535.1±5.2 |
| (10) | 312.7±5.4 |
| (11) | 348.5.1±4.3 |
| BHA | 81.7±10.7 |
As can be seen from Table 10, in table, 11 kinds of samples and BHA have ABTS in various degree
+radical scavenging activity, wherein BHA is traditional synthetic antioxidant; The Scavenging activity of sample (5)-(7) raises gradually, and sample Scavenging activity is (7) best, and is obviously greater than sample (1)-(4) superposition sum; The Scavenging activity of sample (8), (9) is very nearly the same and be slightly weaker than sample (7); Review sample (10), the Scavenging activity of (11) sharply declines, even be weaker than sample (1)-(4) superposition sum, prove that plant protein peptide stock solution of the present invention adopts the effect between each component of specific proportioning with Synergistic thus, it can thus be appreciated that: the plant protein peptide stock solution of 0.12 part of carnosine, 0.06 part of palmityl tripeptides-5,1 part of yeast extract, 6 parts of Herba Silybi mariani extract compositions is the optimum proportioning value of each component of plant protein peptide stock solution of the present invention.
The above embodiment only have expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but therefore can not be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (10)
1. one kind has Firm, reparation, crease-resistant, the plant protein peptide stock solution of improving skin quality effect, it is characterized in that, the active component of described plant protein peptide stock solution comprises the raw material of following weight parts: Herba Silybi mariani extract 1-10 part, carnosine 0.01-0.3 part, palmityl tripeptides-5 0.01-0.2 part, yeast extract 0.1-3 part.
2. according to claim 1 have Firm, reparation, crease-resistant, the plant protein peptide stock solution of improving skin quality effect, it is characterized in that, the active component of described plant protein peptide stock solution comprises the raw material of following weight parts: Herba Silybi mariani extract 5-7 part, carnosine 0.11-0.13 part, palmityl tripeptides-5 0.05-0.07 part, yeast extract 0.9-1.1 part.
3. the preparation method with Firm, reparation, crease-resistant, the plant protein peptide stock solution of improving skin quality effect according to claim 1 and 2, is characterized in that, comprise the following steps:
(1) carnosine, palmityl tripeptides-5 and yeast extract are mixed, obtain mixture, add mannitol, and be dissolved in phosphate buffer, obtain liquid I; The weight of described mixture, mannitol and phosphate buffer is 0.9-1.1:0.9-1.1:0.9-1.1; The pH of described phosphate buffer is 6.7-6.9;
(2) get Herba Silybi mariani extract, be dissolved in hot acetone, the solid-liquid ratio g/ml of Herba Silybi mariani extract and hot acetone liquid is 1:25-35, in 35-55 DEG C of insulation, obtains liquid II;
(3) liquid I is mixed with liquid II, add lecithin, stir 30-90min, add the normal hexane with acetone equivalent after the vacuum concentration to the 1/5-1/6 of original volume of concussion limit, limit, filter after 20-30min, get supernatant liquid, to obtain final product; The addition of described lecithin is 2-3 times of Herba Silybi mariani extract weight.
4. the plant protein peptide stock solution described in claim 1 or 2 has Firm, reparation, crease-resistant, the application improved in the cosmetics of skin quality effect in preparation.
5. cosmetics, is characterized in that, have Firm, reparation, crease-resistant, the plant protein peptide stock solution of improving skin quality effect described in the claim 1 or 2 that described cosmetics include 1-13wt%.
6. an essence, is characterized in that, described essence comprises the component of following weight percentage ratio:
Plant protein peptide stock solution described in claim 1 or 2: 1-13wt%,
1,3-PD: 2-6wt%,
Glycerol: 2-6wt%,
Hyaluronate sodium: 0.05-0.1wt%,
Carbomer: 0.1-0.2wt%,
Xanthan gum: 0.1-0.3wt%,
Methyl hydroxybenzoate: 0.1-0.2wt%,
Sodium hydroxide: 0.01-0.04wt%,
Trehalose: 1-4wt%,
Oligofructose: 0.5-2wt%,
Euglena gracilis polysaccharide and/or hydrolytic collagen: 0.1-0.35wt%,
Aloe vulgaris leaf extract: 0.5-2wt%,
Glycerol polymethacrylates and/or propylene glycol and/or PVM/M copolymer: 1-3wt%,
Ovshinsky Sargassum extract: 1-3wt%,
Pantothenylol: 0.1-0.9wt%,
Laurocapram: 0.1-0.8wt%,
Six peptide-9/1,3-butanediol: 0.1-1wt%,
L-is anti-ruins hematic acid-2-glucoside: 1-3wt%,
Dipeptides-4:0.02-0.07wt%,
Citric acid: 0.01-0.03wt%,
Sodium citrate: 0.1-0.5wt%,
Potassium hydroxide: 0.15-0.55wt%,
Phenoxyethanol: 0.1-0.5wt%,
Methylisothiazolinone and/or iodine propilolic alcohol butyl mephenesin Carbamate: 0.02-0.07wt%,
Deionized water: surplus.
7. a moisturizer, is characterized in that, described moisturizer comprises the component of following weight percentage ratio:
Plant protein peptide stock solution described in claim 1 or 2: 1-13wt%,
Methyl sesquistearate: 0.5-2wt%,
PEG-20 methyl sesquistearate: 0.5-2wt%,
Glyceryl stearate and/or PEG-100 stearate: 0.2-0.9wt%,
Hydrogenated jojoba oil: 1-3wt%,
Hydrogenation macadimia nut seed oil: 1-3wt%,
Isononyl isononanoate: 1-3wt%,
Polydimethylsiloxane: 1-3wt%,
Hydrogenated glucose seed oil: 0.2-0.7wt%,
Tocopherol: 0.2-0.8wt%,
Cetearyl alcohol: 1.0-2.5wt%,
Butylated hydroxytoluene: 0.02-0.08wt%,
Laurocapram: 0.5-2wt%,
1,3-PD: 2-6wt%,
Sorbitol: 4-8wt%,
Hyaluronate sodium: 0.03-0.08wt%,
Methyl hydroxybenzoate: 0.05-0.15wt%,
Xanthan gum: 0.06-0.18wt%,
Sodium acrylate/sodium acryloyldimethyl taurate copolymers and/or Polyoxyethylene Sorbitan Monooleate and/or 2-Methylpentadecane: 0.1-0.5wt%,
Nicotiamide: 1-3wt%,
Euglena gracilis polysaccharide and/or hydrolytic collagen: 0.05-0.2wt%,
Beta glucan: 0.05-0.17wt%,
Pantothenylol: 0.06-0.16wt%,
Six peptides-9 and/or butanediol: 0.15-0.75wt%,
Butanediol/water/peony root extractive: 0.1-0.5wt%,
Ovshinsky Sargassum extract: 1-3wt%,
Methylisothiazolinone: 0.01-0.08wt%,
Phenoxyethanol: 0.15-0.45wt%,
L-is anti-ruins hematic acid-2-glucoside: 0.5-2wt%,
Dipeptides-4:0.01-0.08wt%,
Citric acid: 0.006-0.015wt%,
Sodium citrate: 0.05-0.22wt%,
Potassium hydroxide: 0.08-0.215wt%,
Deionized water: surplus.
8. a late frost, is characterized in that, described late frost comprises the component of following weight percentage ratio:
Plant protein peptide stock solution described in claim 1 or 2: 1-13wt%,
The smooth olive oil acid esters of cetearyl alcohol olive oil acid esters/Pyrusussuriensis: 1-5wt%,
Spermol cetylate and/or the smooth cetylate of Pyrusussuriensis and/or the smooth olive oil acid esters of Pyrusussuriensis: 1-3wt%,
Cetearyl alcohol: 1-3wt%,
Butyrospermum parkii fruit fat: 0.5-1.5wt%,
Caprylic/capric triglyceride: 1-5wt%,
Dicaprylyl carbonate: 1-5wt%,
Hydrogenated olive oil: 1-3wt%,
Titanium dioxide: 0.2-0.7wt%,
Glyceryl stearate: 0.4-1.0wt%,
Tocopherol: 0.2-1.0wt%,
Polydimethylsiloxane: 0.1-0.5wt%,
Laurocapram: 0.5-1.5wt%,
Hyaluronate sodium: 0.05-0.15wt%,
1,3-PD: 1-6wt%,
Sorbitol: 1-6wt%,
Vinyldimethicone/polymethyl siloxane silsesquioxane cross linked polymer: 0.2-0.8wt%,
Fructus Hordei Germinatus oligose glucoside/hydrogenated starch hydrolysate: 0.3-0.8wt%,
1,2-hexanediol/caprylyl glycol: 0.1-0.7wt%,
Phenoxyethanol and/or Sensiva SC50: 0.1-0.3wt%,
Aloe vulgaris leaf extract: 1-3wt%,
Ovshinsky Sargassum extract: 1-3wt%,
Six peptides-9 and/or butanediol: 0.2-0.8wt%,
Beta glucan: 0.5-1.5wt%,
Euglena gracilis polysaccharide and/or hydrolytic collagen: 0.05-0.15wt%,
L-is anti-ruins hematic acid-2-glucoside: 1-3wt%,
Citric acid: 0.01-0.04wt%,
Sodium citrate: 0.1-0.5wt%,
Potassium hydroxide: 0.12-0.44wt%,
Dipeptides-4:0.02-0.07wt%,
Deionized water: surplus.
9. an eye cream, is characterized in that, described eye cream comprises the component of following weight percentage ratio:
Plant protein peptide stock solution described in claim 1 or 2: 1-13wt%,
C14-22 alcohol/C12-20 alkyl androstanediol: 1-2.5wt%,
Glyceryl stearate and/or PEG-100 stearate: 1-2.4wt%,
Cetearyl alcohol: 1.5-3.5wt%,
Laurocapram: 0.5-0.6wt%,
Squalane: 1.0-2.5wt%,
Polydimethylsiloxane: 1-3wt%,
Caprylic/capric triglyceride: 1-2.5wt%,
Butyrospermum parkii fruit fat: 1-3wt%,
Hydrogenated jojoba oil: 1-3wt%,
Methyl hydroxybenzoate: 0.1-0.2wt%,
Propyl hydroxybenzoate: 0.07-0.15wt%,
Hyaluronate sodium: 0.01-0.05wt%,
Xanthan gum: 0.08-0.16wt%,
Glycerol: 1-3wt%,
PEG-8: 3-7wt%,
Polyacrylamide/C13-14 isoparaffin/laureth-7:0.3-0.9wt%,
Polydimethylsiloxane and/or dimethiconol: 0.2-0.7wt%,
Butanediol: 1-2wt%,
Six peptides-9 and/or butanediol: 0.2-0.8wt%,
Aloe vulgaris leaf extract: 0.5-1.5wt%,
Ovshinsky Sargassum extract: 0.5-1.5wt%,
Diazolidinyl urea and/or iodine propilolic alcohol butyl mephenesin Carbamate: 0.2-0.8wt%,
Methylisothiazolinone: 0.01-0.08wt%,
Phenoxyethanol: 0.1-0.35wt%,
L-is anti-ruins hematic acid-2-glucoside: 1-3wt%,
Dipeptides-4:0.01-0.08wt%,
Acetyl tetrapeptide-5:0.05-0.18wt%,
Citric acid: 0.01-0.05wt%,
Sodium citrate: 0.1-0.5wt%,
Potassium hydroxide: 0.15-0.45wt%,
Deionized water: surplus.
10. repair a stock solution, it is characterized in that, described reparation stock solution comprises the component of following weight percentage ratio:
Plant protein peptide stock solution described in claim 1 or 2: 1-13wt%,
Carbomer: 0.1-0.32wt%,
Hyaluronate sodium: 0.15-0.5wt%,
Sodium polyacrylate/Polyethylene Glycol-5M:0.01-0.04wt%,
Butanediol: 0.5-2wt%,
Triethanolamine: 0.1-0.32wt%,
Euglena gracilis polysaccharide and/or hydrolytic collagen: 0.06-0.16wt%,
Acetyl group six peptide-7:1-3wt%,
Seaweed extracted liquor: 0.5-1.5wt%,
Hamamelis virginiana extract: 0.5-1.5wt%,
Phenoxyethanol: 0.15-0.35wt%,
Methylisothiazolinone and/or iodine propilolic alcohol butyl mephenesin Carbamate: 0.02-0.07wt%,
Deionized water: surplus.
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| CN105560086A (en) * | 2016-02-25 | 2016-05-11 | 武汉市农业科学技术研究院林业果树科学研究所 | Pure natural multiple-effect nourishing sunscreen cream containing peony seed oil and preparation method thereof |
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