CN107019656A - A kind of polypeptide whitening anti-wrinkling Essence and preparation method thereof - Google Patents
A kind of polypeptide whitening anti-wrinkling Essence and preparation method thereof Download PDFInfo
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- CN107019656A CN107019656A CN201610164971.9A CN201610164971A CN107019656A CN 107019656 A CN107019656 A CN 107019656A CN 201610164971 A CN201610164971 A CN 201610164971A CN 107019656 A CN107019656 A CN 107019656A
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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Abstract
The invention discloses a kind of polypeptide whitening anti-wrinkling Essence cosmetics and preparation method thereof, the cosmetics are rich in beauty polypeptide moiety, mainly including following components：Asiaticoside, tridecanoic peptide 1, pentapeptide 3, olive oil, glycerine, cetostearyl alcohol, ceteareth 20, shea butter, lipoic acid, milk thistle extract, DMAE sodium tartrate, allantoin, hydrolytic soya bean protein, citric acid, Acritamer 940, dimethicone, pungent glycol, Phenoxyethanol, methyl hydroxybenzoate, ethyl hydroxy benzoate, Nipasol, oxybenzene isobutyl ester, triethanolamine.The Essence has very strong crease-resistant effect, can effectively reduce expression line, smooth cut, fine wrinkles and true property wrinkle；But also with promotion skin cell proliferation, whitening bright color, the effect of desalinating melanin.
Description
Technical field
The present invention relates to cosmetic field, and in particular to a kind of polypeptide whitening anti-wrinkling Essence and preparation method thereof.
Background technology
Skin aging is a kind of lasting gradual physiology course, directly affects the outward appearance and function of skin.With people
The raising of quality of life, anti-aging, firm skin, removes wrinkle, returns to the topic that the youth pays close attention into consumers in general.
Skin aging by objective factors such as age, heredity in addition to being influenceed, also by many factors such as daylight, environment, health
Influence.Undue Exposure to Sunlight is exposed to the sun, and is not only speeded up skin aging, is also also easy to produce pigmented spots；With serious pollution environment is lived in for a long time
In or the chemical substance that is harmful to skin of excessive contact, can all make skin damage, accelerated ageing；Malnutrition, lassitude, disease
Disease is burdened with, and skin is more easy to premature aging.Particularly modern life pressure is big, overtime work stays up late, for a long time to computer, smoking, sleep
Sleep it is not enough, stay in for a long time air-conditioned room, drink, excess eye-using etc. becomes life normality.According to the U.S. beautiful scientific center researchs of Dior,
Daily each layer of skin can accumulate a large amount of cellular elements toxin as caused by inherent or external factor, skin cell can be caused to stop up
Breath, and have impact on the toxin Scavenging activity of skin itself, so as to just generate that the colour of skin is obscure, lack gloss, tired state and show fully etc. and be tired
It is angry；The burden of skin has been aggravated, has accelerated skin aging.
Although skin aging is irreversible physiological phenomenon, its process can delay or slow down.For face wrinkles,
Common anti-wrinkle method is operation smoothing wrinkle, injection anti-wrinkle and anti-wrinkle cosmetic.The treatment cost height of smoothing wrinkle of performing the operation and injection anti-wrinkle,
Risk is big, is not that each consumer can bear, and anti-wrinkle cosmetic is a selection well.
Containing 4%~5% chromatophore in the basal layer cell of human epidermal.The color of human skin is not depend on black
Chromatophore quantity, but depending on quantity, size, distribution and the melanocyte degree of melanosome.Therefore, some whitening compositions
By influenceing formation, maturation and the transfer of melanosome to reach the effect of whitening.
Polypeptide is amino acid composition (50 amino acid hereinafter referred to as polypeptide, 50 amino acid are referred above to albumen), is egg
The middle hydrolysate of white matter, is also the constituent of human body cell.Numerous studies show, not fully water after protein intake
Solution is most of to be absorbed in the form of peptide into amino acid, while it has also been found that, the absorbed speed of polypeptide is than the amino acid with composition
It is fast.
Polypeptide is mainly endogenous polypeptide or other natural polypeptides, and its structure understands, mechanism of action clear and definite, quality control water
Flush and be bordering on traditional small molecule chemicals, and close to albumen in activity, gathered the excellent of conventional chemicals and albumen
Point.
Polypeptide is protein fragments, and structure is widely present in animal and plant body between amino acid and protein, is adjusted
Save the balance of body.Peptide is the source for studying origin of life, structure function and disease, cell and tissue for studying the mankind
Aging, death process is very helpful.
Beauty polypeptide is the polypeptide that a class has beauty functions.The condensation product being made up of multiple amino acid is (common at present
Beauty polypeptide is 2-10 amino condensation compound), but because amino acid classes, sequence are different, its function is entirely different.
Beauty polypeptide to human body because not injuring, effect is obvious, mechanism of action is clear, applies more than 20 abroad
Year, many big shot products all addition (Estee Lauder, it is fragrant how, Christian Dior, Lancome etc.), and China is just at the early-stage, and market should
Consumption is also seldom, and many products are also all to propagandize；But with the cosmetics supervision of state food pharmaceuticals administration general bureau progressively
Strengthen, market is bound to progressively specification.
Beauty polypeptide is because being related to molecular biology, biochemistry, and genetic science, Dermatology and cosmetic science etc. are more
Subject is, it is necessary to long-term, basic and microcosmic in-depth study, while need to set up complete, accurate appraisement system, so
Extensive, the deep application beauty polypeptide in Cosmetics in China market also needs to a process.
Nearly 400,000,000,000 yuan of China cosmetic retail transaction scale (containing personal care product) in 2015, and be in go up year by year
Trend, annual growth is stable 8% or so.Because the application of domestic beauty polypeptide is at the early-stage, and following beauty polypeptide
Using also by a trend as cosmetic industry, so beauty polypeptide skin care item can turn into a strength growth in future
Point.
Therefore, the present invention is after numerous studies, a kind of polypeptide whitening anti-wrinkling Essence is invented.
The content of the invention
It is an object of the invention to propose a kind of polypeptide whitening anti-wrinkling Essence.
The polypeptide whitening anti-wrinkling Essence plays synergy using a variety of beauty polypeptides as main active, promotes newborn thin
Born of the same parents breed, delaying cell aging；And the formation of melanin can also be suppressed, wrinkle, the effect of skin whitening is finally reached.
The present invention to achieve these goals, using following technical scheme：
A kind of polypeptide whitening anti-wrinkling Essence cosmetics, weight percentage, including following components：
Preferably, said composition is by mass percentage, including following component：
Preferably, said composition is by mass percentage, including following component：
Composition of the present invention belongs to existing product, can commercially buy.
As further preferably, described acetyl group hexapeptide -3, tridecanoic peptide -1, the gross weight percentage of the three kinds of beauty polypeptides of pentapeptide -3
Than 25~40%.
As further preferably, described acetyl group hexapeptide -3, tridecanoic peptide -1, the purity of the three kinds of beauty polypeptides of pentapeptide -3 are in 95-
99%.
It is a further object to provide the preparation method of above-mentioned polypeptide whitening anti-wrinkling Essence.
A kind of preparation method of polypeptide whitening anti-wrinkling Essence cosmetics, comprises the following steps：
1) by water, olive oil, glycerine, cetostearyl alcohol, ceteareth -20, shea butter, lipoic acid, dimethylamino
Ethanol sodium tartrate, allantoin, citric acid, Acritamer 940, dimethicone, pungent glycol, Phenoxyethanol, methyl hydroxybenzoate, oxybenzene
Ethyl ester, Nipasol, oxybenzene isobutyl ester, triethanolamine are added in retort, open stirring, are heated to 75~80 DEG C, stirring point
Dissipate uniform；
2) cooling circulating water, stirring cooling, when temperature is down to 40~45 DEG C, by milk thistle extract, hydrolytic soya bean protein are opened
Add in retort, homogeneous 1 minute, stirring and dissolving is complete；
3) continue stirring to be cooled to less than 37 DEG C, acetyl group hexapeptide -3, tridecanoic peptide -1, pentapeptide -3 are added in retort, homogeneous
2-3 minutes, stirring and dissolving completely, terminated.
In the present invention, three kinds of beauty polypeptides are main component.Wherein：
Acetyl group hexapeptide -3 is a kind of beauty polypeptide of use solid-phase synthesis synthesis, is characterized in purity height, to human body
Non-stimulated, beauty clear mechanism, acetyl group hexapeptide -3 is a kind of skin conditioner, wetting agent, can substantially be mitigated by facial expression
The wrinkle that contraction of muscle is produced[1]。
Tridecanoic peptide -1 is a kind of beauty polypeptide of use solid-phase synthesis synthesis, is characterized in that purity is high, stingless to human body
Sharp, beauty clear mechanism, tridecanoic peptide -1 is a kind of skin conditioner, with good whitening, anti-wrinkle effect[2]。
Pentapeptide -3 is a kind of beauty polypeptide of use solid-phase synthesis synthesis, be characterized in purity it is high, non-stimulated to human body,
Beauty clear mechanism, pentapeptide -3 can promote the hyperplasia of collagen, elastic fibers and hyaluronic acid, improve the water content of skin,
Increase skin thickness, so as to significantly suppress thinning of skin and flexibility decrease, slow down the formation of wrinkle[3,4]。
It is another object of the present invention to provide the effect of polypeptide whitening anti-wrinkling Essence.
Polypeptide whitening anti-wrinkling Essence of the present invention is preparing anti aging effect, is suppressing the formation of melanin, skin whitening
Application in cosmetics.
Polypeptide whitening anti-wrinkling Essence of the present invention, also with promotion neonatal cell propagation, delaying cell aging；And can also
Suppress the formation of melanin, be finally reached wrinkle, the effect of skin whitening.
The Essence of the present invention has the advantages that relative to existing product：
1) this product beauty polypeptide moiety content is very high, and containing the natural extract such as milk thistle in being formulated, can efficiently moisturizing,
Moisturizing, nutrition is fed to skin, promotes skin metabolism, is effectively calmed down microgroove, is reduced wrinkle, slowing down skin aging improves
Cutis laxa is sagging, and skin lightening is compacted, and skin water is moistened smooth, high resilience, lifting skin year is slight.
2) polypeptide whitening anti-wrinkling Essence safety and stability of the present invention, good penetrability easily absorbs, salubrious not sticky using rear face；
And preparation method is simple, process stabilizing, can be applicable.
3) the polypeptide whitening anti-wrinkling elite liquid energy can form a fine film in cortical surface, make it have obvious Firm and make
With compared with other products, its effect is more rapid.It is continuous using after 14 days, whitening effect skin and the generation of wrinkle can be reduced.
Brief description of the drawings
The influence that Fig. 1 polypeptide whitening anti-wrinkling Essences change to each group cell proliferation
100 μ L PBS sample human skin fibroblasts HSF 96h forms (10 × 10) (blank are added under Fig. 2 light microscopes
Control)
The sample human skin fibroblasts HSF 96h forms (10 × 10) of 100 μ L embodiments 3 are added under Fig. 3 light microscopes
The sample human skin fibroblasts HSF 96h forms (10 × 10) of 100 μ L embodiments 6 are added under Fig. 4 light microscopes
The sample human skin fibroblasts HSF 96h forms (10 × 10) of 100 μ L embodiments 9 are added under Fig. 5 light microscopes
The situation of change of Fig. 6 polypeptide whitening anti-wrinklings Essence recipient site melanin content during use
The change of Fig. 7 polypeptide whitening anti-wrinklings Essence recipient site L* values during use
Embodiment
By specific examples below, the present invention is further illustrated, but not as the limitation of the present invention.
The each component weight of 1-embodiment of polypeptide whitening anti-wrinkling Essence cosmetics embodiment of the present invention 3 is listed with table 1 below
Measure percentage composition
The preparation method of aforementioned polypeptides whitening anti-wrinkling Essence, comprises the following steps：By water, olive oil, glycerine, cetearyl alcohol
Alcohol, ceteareth -20, shea butter, lipoic acid, DMAE sodium tartrate, allantoin, citric acid, card ripple
Nurse 940, dimethicone, pungent glycol, Phenoxyethanol, methyl hydroxybenzoate, ethyl hydroxy benzoate, Nipasol, oxybenzene isobutyl ester, three ethanol
Amine is added in retort, is opened stirring, is heated to 75~80 DEG C, dispersed with stirring is uniform；Cooling circulating water is opened, stirring cooling is treated
When temperature is down to 40~45 DEG C, milk thistle extract, hydrolytic soya bean protein are added in retort, homogeneous 1 minute, stirring and dissolving
Completely；Continue stirring to be cooled to less than 37 DEG C, acetyl group hexapeptide -3, tridecanoic peptide -1, pentapeptide -3 are added in retort, homogeneous 2-
3 minutes, stirring and dissolving completely, terminated.
The each component weight of 4-embodiment of polypeptide whitening anti-wrinkling Essence cosmetics embodiment of the present invention 6 is listed with table 2 below
Measure percentage composition
The preparation method of aforementioned polypeptides whitening anti-wrinkling Essence, comprises the following steps：By water, olive oil, glycerine, cetearyl alcohol
Alcohol, ceteareth -20, shea butter, lipoic acid, DMAE sodium tartrate, allantoin, citric acid, card ripple
Nurse 940, dimethicone, pungent glycol, Phenoxyethanol, methyl hydroxybenzoate, ethyl hydroxy benzoate, Nipasol, oxybenzene isobutyl ester, three ethanol
Amine is added in retort, is opened stirring, is heated to 70~75 DEG C, dispersed with stirring is uniform；Cooling circulating water is opened, stirring cooling is treated
When temperature is down to 42~45 DEG C, milk thistle extract, hydrolytic soya bean protein are added in retort, homogeneous 1 minute, stirring and dissolving
Completely；Continue stirring to be cooled to less than 37 DEG C, acetyl group hexapeptide -3, tridecanoic peptide -1, pentapeptide -3 are added in retort, homogeneous 2-
3 minutes, stirring and dissolving completely, terminated.
The each component weight of 7-embodiment of polypeptide whitening anti-wrinkling Essence cosmetics embodiment of the present invention 9 is listed with table 3 below
Measure percentage composition
The preparation method of aforementioned polypeptides whitening anti-wrinkling Essence, comprises the following steps：By water, olive oil, glycerine, cetearyl alcohol
Alcohol, ceteareth -20, shea butter, lipoic acid, DMAE sodium tartrate, allantoin, citric acid, card ripple
Nurse 940, dimethicone, pungent glycol, Phenoxyethanol, methyl hydroxybenzoate, ethyl hydroxy benzoate, Nipasol, oxybenzene isobutyl ester, three ethanol
Amine is added in retort, is opened stirring, is heated to 70~75 DEG C, dispersed with stirring is uniform；Cooling circulating water is opened, stirring cooling is treated
When temperature is down to 42~45 DEG C, milk thistle extract, hydrolytic soya bean protein are added in retort, homogeneous 1 minute, stirring and dissolving
Completely；Continue stirring to be cooled to less than 37 DEG C, acetyl group hexapeptide -3, tridecanoic peptide -1, pentapeptide -3 are added in retort, homogeneous 2-
3 minutes, stirring and dissolving completely, terminated.
Embodiment 9, polypeptide whitening anti-wrinkling Essence
Embodiment 10, polypeptide whitening anti-wrinkling Essence
Embodiment 11, polypeptide whitening anti-wrinkling Essence
Embodiment 12, polypeptide whitening anti-wrinkling Essence
Properties of product evaluation test of the present invention is as follows：
First, embodiment 3, embodiment 6, embodiment 9 carry out human skin fibroblasts HSF proliferation experiments.
After human skin fibroblasts HSF cell recoveries, it is grown in RPMI-1640 complete mediums, it is full at 37 DEG C
Cultivate, passed on when cell fusion degree reaches 80% with humidity, 5%CO2 incubator.Collect the HSF grown fine
Cell, is then resuspended in culture medium；It is inoculated with 28 bottles of cells, cell density 5 × 104Individual/mL；It is real after after cell attachment, adding
Apply the PBS that the elite liquid product of the implementation group of example 3,6,9, blank control add same volume, every bottle of 100 μ L of addition.With platform
Expect that indigo plant refuses dye method to cell continuous counter seven days, every bottle of cell count three times is averaged, draws the cell for adding different component
Rising in value, (4) such as Fig. 1, data are shown in Table curve.
The influence that the polypeptide whitening anti-wrinkling Essence of table 4 changes to each group cell proliferation
Unit：Ten thousand
Experimental result：From cell proliferation experiment result, embodiment 3, embodiment 6, the Essence sample of 9 groups of embodiment
To the proliferative effects of HSF cells apparently higher than blank control group, and the cell photo shot also can significant reaction this influence,
And the best results of implementation group 3.In addition, this cell can manufacture the protein such as collagen, and it is that aged cells supplement the nutrients, side
Show that polypeptide whitening anti-wrinkling Essence can be by promoting the value-added mode of cell to reach crease-resistant effect.
2nd, the efficacy validation that wrinkles is removed：
The volunteer for selecting 90 facial wrinkles degree close, is divided into 9 groups, every group of 10 people, product acts on eye, sooner or later
Respectively once, it is continuous to use one month.
Anti-wrinkle effect is described：
Substantially：Deep line is unfolded not substantially, and microgroove disappears, and skin-tightening is flexible, and relaxation sense disappears；
Alleviate：Deep crenulation degree mitigates, and microgroove is unfolded not substantially, and skin-tightening, relaxation sense disappears；
It is slight to improve：Microgroove mitigates, and skin is flexible, and relaxation sense disappears.
As a result：In 90,66% is significantly accounted for using product effect of the present invention, what moderate improved accounts for 23%, altogether effectively
Rate is 100%, and adverse reaction occurs in none example of whole subjects.
3rd, the Whitening, spot effect of embodiment 3 is evaluated
The polypeptide whitening anti-wrinkling Essence provided in this experimental selection embodiment 3 is tested.
Select 30 ages in 23~50 years old healthy women, determine the pigment content and skin color of its cheek, Ran Houfa
Put tested cosmetics.Study subject continuously uses polypeptide whitening anti-wrinkling Essence sample.The left and right cheek portion of tester, is compared
Experiment, sooner or later each daily to use 1 time, application after face cleaning.Other skin-lightening cosmetics are disabled during testing.Continuous use 7d,
After 14d, 21d, 30d, then determine each efficacy measures.Inquire volunteer using being felt after given the test agent and whether there is allergy simultaneously
Phenomenon etc., records contrast before and after itself.Lab colorimeter systems are being utilized using the preceding 1d of cosmetics and using rear 7d, 14d, 21d, 30d
Spectrophotometer measures the change of skin color, and follow-on test 3 times is averaged.MEXAMETER MXl8 skins are used simultaneously
Pigment instrument surveys dermal melanin content, and follow-on test 3 times is averaged.Data processing is carried out using sigmastat statistical softwares
Paired t-test, with P<0.05 tool significance.
The situation of change of recipient site dermal melanin content before and after experiment：30 study subjects of this experiment have to sample
Good tolerance, has no adverse reaction.As shown in Figure 1 (data are shown in Table 1), experimental group using 7d after sample, 14d,
21d, 30d melanin content reduce (P compared with before<0.05).
The situation of change of the polypeptide whitening anti-wrinkling Essence of table 5 recipient site melanin content during use
The situation of change of recipient site skin colourity L* values before and after experiment：Skin colourity L* values are bigger, represent skin color
It is more shallow.7d after product use, skin colourity L* values just have increased trend, since 14d, are just significantly greater than water before testing
Flat (P<0.05) (see Fig. 2,2) data are shown in Table, and gradually increased trend is presented with the extension of product use time in L* values.
The change of the polypeptide whitening anti-wrinkling Essence of table 6 recipient site L* values during use
In summary, the whitening product has a significant white-skinned face function, i.e., dual with bright color and desalination color spot
Effect.
4th, polypeptide whitening anti-wrinkling Essence stability test result
According to 2660-2004 couples of People's Republic of China (PRC) light industry standard QB/T it is made contain 10% acetyl group hexapeptide-
3rd, 10% tridecanoic peptide -1, the polypeptide whitening anti-wrinkling Essence of 5% pentapeptide -3 carry out sense organ, physicochemical property test, as a result such as the institute of table 7
Show.As shown in Table 7, the testing result of polypeptide whitening anti-wrinkling Essence color, turbidity, cold-resistant heat resistant test and acid-base value is accorded with
People's Republic of China (PRC) light industry standard 0B/T 2660-2004 sense organ, physical and chemical index regulation is closed, shows that three kinds of addition is right
The quality index of polypeptide whitening anti-wrinkling Essence is substantially without influence.
The polypeptide whitening anti-wrinkling Essence Detection of Stability result of table 7
| Project | As a result |
| Outward appearance | Uniform liquid is free from foreign meter |
| Heat-resistant experiment | (40 ± 1) DEG C keep 24h, recover to room temperature preceding without obvious Traits change with experiment |
| Cold-resistant experiment | (5 ± 1) DEG C keep 24h, recover to room temperature preceding without obvious Traits change with experiment |
| pH | About 7.0 |
By polypeptide whitening anti-wrinkling elite liquid product made from example 1, embodiment 3, embodiment 5, embodiment 7, embodiment 9,
Experimental comparison is carried out with existing whitening anti-wrinkling elite liquid product, experiment condition is：60 women of volunteer, age 20-45 Sui,
Use 2 times daily, it is continuous to use 28 days.Shown in experimental result such as following table (table 8)：
The contrast of the polypeptide whitening anti-wrinkling Essence of table 8 and existing whitening anti-wrinkling Essence
From above-mentioned contrast test, the beauty anti-wrinkle effect of embodiment 3 is optimal, and other embodiment group is compared with existing product
There is different degrees of effect.
In above-mentioned experiment, the present invention selects section Example as Experimental agents, but in fact, other implementations of the present invention
Example can also obtain same or similar beneficial effect.
Bibliography
[1] Zhong Xing, Guo Jianwei, Cheng Qiugui win application and latest developments [J] household chemicals science of the peptide in cosmetics,
2012,35 (11)：35-38.
[2]Papini A M.Cosmetics towards peptide-based cosmeceutics[J]
.ChimicaOggi/Che-mistry Today,2010,28(6):3-4
[3] the 10th south east asia medical cosmetology of application [c] of yellow Yadong biologically active polypeptides in medical cosmetology is academic
Conference collection of thesis, 2006：14—17
[4] Li Jiaokun, Yao Chengcan, the basis of the biologically active polypeptide skin care item such as yellow Yadong and apply fJ1. daily chemical industries,
2002,32 (5)：41—43.
Claims (10)
1. a kind of polypeptide whitening anti-wrinkling Essence, it is characterised in that weight percentage, including following components：
2. a kind of polypeptide whitening anti-wrinkling Essence according to claim 1, it is characterised in that weight percentage,
Including following components：
3. a kind of polypeptide whitening anti-wrinkling Essence according to claim 2, it is characterised in that weight percentage,
Including following components：
4. a kind of polypeptide whitening anti-wrinkling Essence according to claim 1 or 2 or 3, it is characterised in that described acetyl group
Hexapeptide -3, tridecanoic peptide -1, the total weight percent of the three kinds of beauty polypeptides of pentapeptide -3 are 25~40%.
5. a kind of polypeptide whitening anti-wrinkling Essence according to claim 1 or 2 or 3, it is characterised in that described acetyl group
Hexapeptide -3, tridecanoic peptide -1, the purity of the three kinds of beauty polypeptides of pentapeptide -3 are in 95-99%.
6. a kind of polypeptide whitening anti-wrinkling Essence according to claim 1, it is characterised in that weight percentage,
Including following components：
7. a kind of polypeptide whitening anti-wrinkling Essence according to claim 1, it is characterised in that weight percentage,
Including following components：
8. a kind of polypeptide whitening anti-wrinkling Essence according to claim 1, it is characterised in that weight percentage,
Including following components：
9. a kind of method of the polypeptide whitening anti-wrinkling Essence prepared described in Claims 1 to 5 any one claim, it is special
Levy and be, this method comprises the following steps：
1) by water, olive oil, glycerine, cetostearyl alcohol, ceteareth -20, shea butter, lipoic acid, dimethylamino
Ethanol sodium tartrate, allantoin, citric acid, Acritamer 940, dimethicone, pungent glycol, Phenoxyethanol, methyl hydroxybenzoate, oxybenzene
Ethyl ester, Nipasol, oxybenzene isobutyl ester, triethanolamine are added in retort, open stirring, are heated to 75~80 DEG C, stirring point
Dissipate uniform；
2) cooling circulating water, stirring cooling, when temperature is down to 40~45 DEG C, by milk thistle extract, hydrolytic soya bean protein are opened
Add in retort, homogeneous 1 minute, stirring and dissolving is complete；
3) continue stirring to be cooled to less than 37 DEG C, acetyl group hexapeptide -3, tridecanoic peptide -1, pentapeptide -3 are added in retort, homogeneous
2-3 minutes, stirring and dissolving completely, terminated.
10. polypeptide whitening anti-wrinkling Essence described in claim 1 is in formation, the whitening for preparing anti aging effect, suppressing melanin
Application in the cosmetics of skin.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108578263A (en) * | 2018-06-20 | 2018-09-28 | 吉林农业科技学院 | Silymarin Skin whitening care cosmetics |
| CN110604717A (en) * | 2019-10-30 | 2019-12-24 | 海南女人春天美容有限公司 | Tightening and lifting essence milk and preparation method thereof |
| CN115252457A (en) * | 2022-08-25 | 2022-11-01 | 上海百雀羚生物科技有限公司 | Composition with whitening and brightening effects and application of composition in cosmetics |
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| CN108578263A (en) * | 2018-06-20 | 2018-09-28 | 吉林农业科技学院 | Silymarin Skin whitening care cosmetics |
| CN110604717A (en) * | 2019-10-30 | 2019-12-24 | 海南女人春天美容有限公司 | Tightening and lifting essence milk and preparation method thereof |
| CN115252457A (en) * | 2022-08-25 | 2022-11-01 | 上海百雀羚生物科技有限公司 | Composition with whitening and brightening effects and application of composition in cosmetics |
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