CN108524371A - A kind of composition and its application in preparing the cosmetics with anti-senescence function - Google Patents
A kind of composition and its application in preparing the cosmetics with anti-senescence function Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
A kind of application the present invention relates to cosmetic technical field more particularly to composition and its in preparing the cosmetics with anti-senescence function.The present invention is compounded Honegsukle flower P.E, camellia flower extract, Herba Saussureae Involueratae extract, and resulting composition is mixed with components such as glycerine, and the Essence of formation can remove free radical, promote fibroblast proliferation, to have the function of anti-aging.Experiment shows that Essence of the invention, up to 54.84%~56.01%, improves fibroblastic proliferation rate to 14.67%~24.97% to free radical scavenging activity.
Description
Technical field
The present invention relates to cosmetic technical field more particularly to a kind of composition and its preparing with anti-senescence function
Application in cosmetics.
Background technology
Loving beauty is part of human nature, and beautiful pursuit is continuously improved with the progress of civilization by the mankind.Chinese beauty culture source
Remote stream length, can trace back to the Neolithic Age earliest, be the indispensable component part of human lives.The beauty culture of the Chinese nation
In, in addition to liking natural beauty, also like that beautification of the mind and appearance are beautiful.Traditional Chinese medicine beautifying is that based on TCM theory, have with some
The method and prescription of tcm characteristic are means, by adjusting viscera function, improve blood circulation, beautiful to realize cleaning face
Change the purpose of skin.Classical ancient books is consulted, many ancient times beauties are familiar with the road of beauty treatment, commonly using the production with moistening face
Product.
With the raising of social progress and living standards of the people, the consciousness that people pursue health is increasingly enhanced, due to planting
Object active constituent not only Small side effects but also effect is preferable, the beauty product based on active components of plants is increasingly consumed
The favor of person.It is detached from natural plants or Chinese medicine, extraction active constituent makes cosmetics and skincare product and increasingly causes attracting attention for the world.
Currently, chaotic by the kind of the cosmetics of raw material of plant in the market, quality is very different.Analyze reason, a side
That face is that individual businessmans pursue is benefit, passes a fake product off as a genuine one, is substituted the bad for the good with bad；On the other hand, to be the formulas of cosmetics do not have
By further verifying, synergistic effect cannot be played between each component well；And more important reason is, plant
Component and other components matchings in cosmetics are improper, cause the degradation and failure of plant component.Therefore, it should further develop
Plant material, and make these raw materials are good to be applied in cosmetics.
Invention content
In view of this, the technical problem to be solved in the present invention is to provide a kind of composition and its has anti-aging preparing
Application in the cosmetics of function；Composition provided by the invention has the function of anti-oxidant, anti-aging.
Composition provided by the invention is grouped as by the group of following mass fraction：
0.3 part~1 part of camellia flower extract；
0.3 part~1 part of Herba Saussureae Involueratae extract；
0.5 part~1 part of Honegsukle flower P.E.
In some embodiments, the composition is grouped as by the group of following mass fraction：
0.3 part of camellia flower extract；
0.3 part of Herba Saussureae Involueratae extract；
0.5 part of Honegsukle flower P.E.
In some embodiments, the composition is grouped as by the group of following mass fraction：
0.5 part of camellia flower extract；
0.5 part of Herba Saussureae Involueratae extract；
0.5 part of Honegsukle flower P.E.
Present invention employs honeysuckle, natural snow lotus flower, peony are " anti-ageing to spend " prescription, which can inhibit scorching
Inflammation factor eliminates oxygen radical, inhibits metalloproteinases, prevents degradation of cell epimatrix, promotes collagen hyperplasia, accelerates blood
Liquid recycles, and boosts metabolism, effectively avoids DNA Damage, effectively pre- anti-aging.
The present invention also provides a kind of Essences, by glycerine, butanediol, propylene glycol, beta glucan, oligomerization hyaluronic acid
Sodium, trehalose, niacinamide, inositol, carnosine, ursin and composition of the present invention composition.
The present invention compounds camellia flower extract, Herba Saussureae Involueratae extract, Honegsukle flower P.E, resulting composition
It is used to prepare the Essence of cosmetics, experiment shows the Essence to being 54.84%~56.01% to free radical scavenging activity, energy
The damage that the removing free radical of relative efficiency generates cell there is preferable repair to defend the intact of skin barrier.The essence
Magnificent liquid can also effectively improve cell proliferation rate and reach 14.67%~24.37%, have and preferably promote cell-proliferation activity, delay
Aging.
In the Essence, the components such as glycerine, butanediol, propylene glycol can coordinate composition provided by the invention, further
Improve the effect of composition removed free radical, improve cell-proliferation activity.
Specifically, Essence provided by the invention is grouped as by the group of following mass fraction：
In some embodiments, Essence provided by the invention is grouped as by the group of following mass fraction：
In some embodiments, Essence provided by the invention is grouped as by the group of following mass fraction：
In some embodiments, Essence provided by the invention is grouped as by the group of following mass fraction：
Further include water, preservative and thickener in Essence provided by the invention.
The preservative is PHL；The thickener is xanthans.
In the Essence, the mass fraction of water is 84.61%~86.51%.
Wherein, the mass fraction of the preservative is 1%, and the mass fraction of the thickener is 0.15%.
Application of the Essence of the present invention in preparing oxidation resistant cosmetics.
The antioxygen turns to removing free radical.
Application of the Essence of the present invention in the cosmetics for preparing anti-aging.
The anti-aging is to improve fibroblastic proliferation rate.
The preparation method of Essence of the present invention includes：
75 DEG C~80 DEG C, by glycerine, butanediol, propylene glycol, oligomerization Sodium Hyaluronate, trehalose, beta glucan, black bearberry
Glycosides, niacinamide, inositol, thickener and water mixing, 500r/min~600r/min stir 30min；
55 DEG C~60 DEG C are cooled to, sequentially adds carnosine, camellia flower extract, Herba Saussureae Involueratae extract, honeysuckle carries
Object, 300r/min~350r/min is taken to stir 15min；
45 DEG C~50 DEG C are cooled to, preservative is added, 150r/min~200r/min stirs 10min；It is cooled to room temperature.
The room temperature is 18 DEG C~30 DEG C.
The present invention also provides a kind of anti-oxidant and/or anti-aging cosmetics, including Essence of the present invention.
Cosmetics of the present invention include：Mask or eye sticker patch.
The cosmetics are facial mask, then wherein also include mask matrix.
The present invention compounds camellia flower extract, Herba Saussureae Involueratae extract, Honegsukle flower P.E, resulting composition
It is used to prepare the Essence of cosmetics, experiment shows that the Essence is 54.84%~56.01% to free radical scavenging activity, can phase
The damage generated to cell to efficiently removing free radical there is preferable repair to defend the intact of skin barrier.The essence
Liquid can also effectively improve cell proliferation rate and reach 14.67%~24.37%, have and preferably promote cell-proliferation activity, delay to decline
Always.
Description of the drawings
Fig. 1 shows the removing free radical effect of different samples；
Fig. 2 shows influence of the different samples to cell proliferation rate.
Specific implementation mode
A kind of application the present invention provides composition and its in preparing the cosmetics with anti-senescence function, this field
Technical staff can use for reference present disclosure, be suitably modified technological parameter realization.In particular, it should be pointed out that all similar replacements
Apparent to those skilled in the art with changing, they are considered as being included in the present invention.The method of the present invention
And application is described by preferred embodiment, related personnel can obviously not depart from the content of present invention, spirit and model
Enclose it is interior to methods herein and application be modified or suitably change and combine, to realize and apply the technology of the present invention.
The raw material that the present invention uses is all common commercially available product, can all be bought in market.
Honeysuckle also known as honeysuckle flowers are half evergreen voluble shrub of Caprifoliaceae.Honegsukle flower P.E provided by the invention is main
Containing chlorogenic acid, isochlorogenic acid, cyanidenon and saponin(e, it can effectively inhibit golden yellow Portugal coccus, Escherichia coli, Pseudomonas aeruginosa
Deng, and 1L-4 levels can be promoted, neurocalcin is activated, macrophage function is enhanced, protects collagen.The present invention uses
Hunan Longhui spends the green phase of the precious jade area rivers little Sha honeysuckle three, i.e., prepares honeysuckle flower extract using green flower bud, and plucking time is upper
Noon 9:00 to 11：00；The preparation of extract uses water extraction.After testing, the extract Content of Chlorogenic Acid and isopropyl chlorogenic acid activity
Constituent content is higher, has excellent antibacterial, anti-inflammatory and antioxygenic property.
Camellia (Camellia sp.) also known as camellia, are the common names of Theaceae, Camellia various plants and garden-variety.
The present invention is extracted using the flower of camellia as raw material with water extract method, and main component is in the camellia flower extract of preparation
Tea Saponin, tea polyphenols, catechin.
Saussurea involucrata also known as lanatechead saussurea herb with flower belong to composite family Genus Saussurea, and because of its top likeness in form lotus flower, therefore lanatechead saussurea herb with flower leaves of gaining the name are intensive, most
Upper leaf bract shape, film quality is faint yellow, surrounds total inflorescence, little Hua purples.The Herba Saussureae Involueratae extract, with the small pale reddish brown of saussurea involucrata
It for raw material, is extracted with alcohol extraction, extract obtained active constituent is mainly xuelianlactone, flavonoids rutin.
Glycerine is also known as glycerine, has water sorption, is used as moisturizer.
Butanediol is one kind of polyalcohol, is often used as moisturizer or solvent in cosmetics, the fourth that the present invention uses
Glycol is 1,3 butanediols
Propylene glycol has the function of moisturizing and antibacterial, and the propylene glycol that the present invention uses is 1,2-PD
Beta glucan is also known as dextran, mainly by D- glucopyanosyls with α, 1 → 6 key connection, branch point has 1 → 2,
1 → 3,1 → 4 connection.The molecular weight for the beta glucan that the present invention uses is 60,000-50 ten thousand.
Oligomerization Sodium Hyaluronate is the extremely low hyaluronan molecule of the molecular weight that is prepared by hyaluronic acid degradation, has skin
The function of moisturizing.The molecular weight for the oligomerization Sodium Hyaluronate that the present invention uses is 10000.
Trehalose is anhydrous trehalose, also known as Radix Rhapontici seu Radix Echinopsis sugar, gill fungus sugar etc., has the function of cytoprotection.
Niacinamide, also known as niacinamide are the amide compounds of niacin, and nutritive additive is used as in cosmetics.
Inositol also known as inose, inositol or inositol (inose), participate in internal metabolic activity.
Carnosine (L-Carnosine), scientific name β-alanyl-L-histidin, be by be one kind by Beta-alanine and L- group ammonia
The dipeptides of sour two kinds of amino acid composition, can remove the aliphatic acid excessive oxidation for making cell membrane during oxidative stress and be formed in fact
Active oxygen radical (ROS) and alpha-beta unsaturated aldehyde.
Ursin also known as Arbutin can reduce Skin pigmentation, dispelling stain and freckle, while also have and sterilize, disappear
Scorching effect.It is extractable from plant, can also be synthesized by artificial chemistry.
With reference to embodiment, the present invention is further explained：
Examples 1 to 3
Formula such as table 1
1 Examples 1 to 3 formula of table
| Component | Embodiment 1 | Embodiment 2 | Embodiment 3 |
| Glycerine | 3g | 3g | 3g |
| Butanediol | 5g | 5g | 5g |
| Propylene glycol | 2g | 2g | 2g |
| Beta glucan | 0.1g | 0.1g | 0.1g |
| Oligomerization Sodium Hyaluronate | 0.01g | 0.01g | 0.01g |
| Trehalose | 0.01g | 0.01g | 0.01g |
| Niacinamide | 1g | 1g | 1g |
| Inositol | 0.1g | 0.1g | 0.1g |
| Carnosine | 0.01g | 0.01g | 0.01g |
| Ursin | 0.01g | 0.01g | 0.01g |
| Honegsukle flower P.E | 0.5g | 0.5g | 1g |
| Camellia flower extract | 0.3g | 0.5g | 1g |
| Herba Saussureae Involueratae extract | 0.3g | 0.5g | 1g |
| PHL | 1g | 1g | 1g |
| Xanthans | 0.15g | 0.15g | 0.15g |
| Water | 86.51g | 86.11g | 84.61g |
1) according to formulation ratio weigh glycerine, butanediol, propylene glycol, oligomerization Sodium Hyaluronate, trehalose, beta glucan,
Niacinamide, inositol, ursin, xanthans and deionized water raise the temperature to 75~80 DEG C, with 500~600r/min, stirring
30min, until component all dissolves；
2) temperature is reduced to 55~60 DEG C, carnosine, Honegsukle flower P.E, camellia flower extract, Herba Saussureae Involueratae is added
Extract stirs 15min with 300~350r/min, until all uniformly mixing；
3) temperature is reduced by 45~50 DEG C, adds preservative PHL, 10min is stirred with 150~200r/min, is cooled to room
Temperature.
Comparative example 1~4
Formula such as table 2
2 comparative example 1~4 of table is formulated
| Component | Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 |
| Glycerine | 3g | 3g | 5g | 3g |
| Butanediol | 5g | 5g | 2g | 5g |
| Propylene glycol | 2g | 2g | 3g | 2g |
| Beta glucan | 0.1g | 0.1g | 0.1g | 0.1g |
| Oligomerization Sodium Hyaluronate | 0.01g | 0.01g | 0.01g | 0.01g |
| Trehalose | 0.01g | 0.01g | 0.01g | 0.01g |
| Niacinamide | 1g | 1g | 1g | 1g |
| Inositol | 0.1g | 0.1g | 0.1g | 0.1g |
| Carnosine | 0.01g | 0.01g | 0.01g | 0.01g |
| Ursin | 0.01g | 0.01g | 0.01g | 0.01g |
| Honegsukle flower P.E | -- | 3g | 1.88g | 1.43g |
| Camellia flower extract | -- | -- | 1.12g | 1.43g |
| Herba Saussureae Involueratae extract | -- | -- | -- | 0.14g |
| PHL | 1g | 1g | 1g | 1g |
| Xanthans | 0.15g | 0.15g | 0.15g | 0.15g |
| Water | 87.61g | 84.61g | 84.61g | 84.61g |
1) according to formulation ratio weigh glycerine, butanediol, propylene glycol, oligomerization Sodium Hyaluronate, trehalose, beta glucan,
Niacinamide, inositol, ursin, xanthans and deionized water raise the temperature to 75~80 DEG C, with 500~600r/min, stirring
30min, until component all dissolves；
2) temperature is reduced to 55~60 DEG C, carnosine, Honegsukle flower P.E, camellia flower extract, Herba Saussureae Involueratae is added
Extract stirs 15min with 300~350r/min, until all uniformly mixing；
3) temperature is reduced by 45~50 DEG C, adds preservative PHL, 10min is stirred with 150~200r/min, is cooled to room
Temperature.
Effect is evaluated and tested
1DPPH method free radical scavenging abilities measure
1.1 tests prepare
(1) DPPH test fluids configure
Precise 1mgDPPH, 95% ethyl alcohol constant volume and 50ml volumetric flasks, ultrasonic 3min are allowed to be completely dissolved.Measure 1ml
Solution measures absorbance A at 519nm, and A values can be used between 0.6~0.8.
(2) Vc standard curve determinations
Vc is configured to five various concentrations of 0.1,0.2,0.3,0.4,0.5mmol/L with deionized water.It is added in small test tube
2ml DPPH solution, 100 μ lVc solution, 400 μ l95% ethyl alcohol, mixing shake up, and stand 5min, survey A values (519nm).Blank pair
According to for 100 μ l deionized waters.Mapping -1 concentration-absorbance standard curve.
Vc clearance rates=(A0-AX)/A0
A0：Deionized water blank control, Ax：Vc absorbances
(3) sample measures
Sample solution 100ul is detected according to step in (2), and to avoid solution colour from influencing, setting is not added with DPPH control groups,
It is that sample absorbance subtracts control group absorbance to calculate absorbance.Three panel datas will be surveyed by often surveying a used in amounts.And
After often surveying three panel datas of a dosage, an A0 will be resurveyed.Measure sample absorbance, clearance rate, comparison Vc antioxygens
Change ability and sample total antioxidant capacity such as table -1.
1.2 experimental results as shown in Figure 1, as seen from the figure, prescription of the present invention to the clearance rate of free radical up to 54.84%~
57.08%, illustrate that prescription of the present invention has preferable free radical scavenging activity, endogenic delaying cell aging.
2 fibroblast proliferation rates
2.1 experimental principle:
Method for cell count：Based on method for cell count is carried out using blood cell counting plate, by white blood cell count(WBC) method
After calculating the preparation of cell suspensions, common vital stain trypan blue dyes cell, carries out cell count.Trypan blue cannot be saturating
Living cells normally complete cell membrane is crossed, therefore living cells is not colored.And the permeability of cell membrane of dead cell increases, and can make dyestuff
Into intracellular and make cell color (blue).
2.2 experiment materials and method
Experiment material:DMEM, DPBS, Typsin-EDTA, Petri dish, 96well dish, 0.4% trypan blue are molten
Liquid, absolute ethyl alcohol or 95% ethanol solution, simple microscope, cell counting board, liquid-transfering gun, MTT, DMSO
2.3 experimental method：
2.3.1 Fibroblast cell-culture
1) it is collected after handling cultured fibroblast with Typsin-EDTA, haemocyte is utilized after being suspended with DMEM
Suspension is diluted to a concentration of the 5 × 10 of cell by tally after counting4Cells/ml is spare
2) ready cell suspending liquid is distinguished in plant division to 96well dish and 6well dish and cultivates, wherein
96well dish inoculum concentrations are 100ul, and 6well dish inoculum concentrations are 2ml.
3) at 37 DEG C, 5%CO2Incubator in cultivate 24 hours.
2.4. sample adds
1) sample to be tested trains base dilution with DMEM, and the concentration after dilution is respectively：1% (the MTT surveys that the concentration passes through front
Examination, result are nontoxic)
2) after cell culture 24 hours, the DMEM before removing, after then carefully being washed with DPBS
3) the DMEM culture mediums for being added to sample to be tested that the first step prepares are added in sequence.
4) at 37 DEG C, 5%CO2Incubator in cultivate 48 hours.
2.5 cell count
1) tally is handled
After absolute ethyl alcohol or 95% ethanol solution wiping tally, is cleaned with silk, separately clean coverslip one and open, lid
Piece overlays on above tally.
2) it dyes
The cell for taking 6well dish to cultivate is digested after removing culture medium using typsin-EDTA, is used after collecting cell
DMEM culture mediums suspend.0.4% trypan blue dye liquors of 10ul are drawn with liquid-transfering gun and 10ul cell suspensions are uniformly mixed.From counting
Edges of boards edge slowly injects, and is allowed to full of in the gap between tally and cover plate.Tally is placed under low power lens (10 × 10
Times) observation counting.
3) method of counting
By the cell number in the quadrangle block plaid (each block plaid is divided into 16 lattices) of figure count plate.It counts
When, complete cell is only counted, is counted by a cell if the cell to bunch up.In a block plaid, if
There is cell to be located on line, generally count offline cell and disregard cell of reaching the standard grade, counts left line cell and disregard right line cell.Under the microscope, all
Refractivity is by force living cells without tinter, and colors blue person is dead cell.
4) conversion counted
After counting number, the cell number in every ml suspensions is conversed.Since the area of each grid in tally is
0.01cm2, a height of 0.01cm, in this way its volume are 0.0001cm3, i.e. 0.1mm3.Due to 1ml=1000mm3, so each
The 000=cell numbers of block plaid inner cell number × 10/ml, therefore can be calculated as follows：
Cell suspension cell number/ml=4 big lattice total number of cells/4 × 10000
It has been diluted before such as counting, it can be multiplied by extension rate.After counting cell, the dense of cell in cell suspension can be calculated
Degree.On the basis of blank sample, the cell proliferation rate of each sample is calculated.
2.6 fibroblast proliferation results
As a result such as Fig. 2, as shown in the figure：Prescription of the present invention can promote cell proliferation rate, by cell proliferation rate improve to
14.67%~24.37%, through statistical analysis, the effect of Examples 1 to 3, conspicuousness is better than each comparative example (p<0.05),
Wherein, the significant effect of embodiment 2~3 be better than 1 (p of comparative example 1~4 and embodiment<0.05), and embodiment 3 is to thin
The facilitation of born of the same parents' proliferation is optimal, and conspicuousness is better than each comparative example and Examples 1 to 2 (p<0.05).
It the above is only the preferred embodiment of the present invention, it is noted that those skilled in the art are come
It says, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications also should be regarded as
Protection scope of the present invention.
Claims (10)
1. a kind of composition, which is characterized in that be grouped as by the group of following mass fraction：
0.3 part~1 part of camellia flower extract；
0.3 part~1 part of Herba Saussureae Involueratae extract；
0.5 part~1 part of Honegsukle flower P.E.
2. composition according to claim 1, which is characterized in that be grouped as by the group of following mass fraction：
0.5 part of camellia flower extract；
0.5 part of Herba Saussureae Involueratae extract；
0.5 part of Honegsukle flower P.E.
3. a kind of Essence, which is characterized in that by glycerine, butanediol, propylene glycol, beta glucan, oligomerization Sodium Hyaluronate, seaweed
Sugar, niacinamide, inositol, carnosine, ursin and composition as claimed in claim 1 or 2 composition.
4. Essence according to claim 3, which is characterized in that be grouped as by the group of following mass fraction：
5. Essence according to claim 3 or 4, which is characterized in that further include water, preservative and thickener.
6. Essence according to claim 5, which is characterized in that the mass fraction of the water be 84.61%~
86.51%.
7. application of any one of claim 3~6 Essence in preparing anti-oxidant and/or anti-aging cosmetics.
8. the preparation method of any one of claim 3~6 Essence, which is characterized in that including：
75 DEG C~80 DEG C, by glycerine, butanediol, propylene glycol, oligomerization Sodium Hyaluronate, trehalose, beta glucan, ursin, cigarette
Amide, inositol, thickener and water mixing, 500r/min~600r/min stir 30min；
55 DEG C~60 DEG C are cooled to, sequentially adds carnosine, camellia flower extract, Herba Saussureae Involueratae extract, Honegsukle flower P.E,
300r/min~350r/min stirs 15min；
45 DEG C~50 DEG C are cooled to, preservative is added, 150r/min~200r/min stirs 10min；It is cooled to room temperature.
9. a kind of anti-oxidant and/or anti-aging cosmetics, which is characterized in that including any one of claim 3~6 essence
Liquid.
10. cosmetics according to claim 9, which is characterized in that it is facial mask, further includes mask matrix.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109394677A (en) * | 2018-12-27 | 2019-03-01 | 杭州宝格丽生物科技有限公司 | It is a kind of with anti-oxidant, anti-aging effects cosmetics |
| CN110179735A (en) * | 2019-07-10 | 2019-08-30 | 湖北省吉美化妆品有限公司 | Have effects that Vitamin K, the plant composition for eye pouch of dispelling and its application in external use skin care |
| CN110585100A (en) * | 2019-10-15 | 2019-12-20 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine composition with moisturizing and anti-aging functions and preparation method and application thereof |
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| CN105168040A (en) * | 2015-08-18 | 2015-12-23 | 广东轻工职业技术学院 | Composite anti-ageing skin-care composition and manufacturing method |
| CN105997754A (en) * | 2016-07-25 | 2016-10-12 | 上海得高实业有限公司 | Camellia extraction liquid, and preparation method and application thereof |
| CN107049880A (en) * | 2017-06-16 | 2017-08-18 | 湖南御家化妆品制造有限公司 | Lightening compositions and its application |
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| CN105168040A (en) * | 2015-08-18 | 2015-12-23 | 广东轻工职业技术学院 | Composite anti-ageing skin-care composition and manufacturing method |
| CN105997754A (en) * | 2016-07-25 | 2016-10-12 | 上海得高实业有限公司 | Camellia extraction liquid, and preparation method and application thereof |
| CN107049880A (en) * | 2017-06-16 | 2017-08-18 | 湖南御家化妆品制造有限公司 | Lightening compositions and its application |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109394677A (en) * | 2018-12-27 | 2019-03-01 | 杭州宝格丽生物科技有限公司 | It is a kind of with anti-oxidant, anti-aging effects cosmetics |
| CN110179735A (en) * | 2019-07-10 | 2019-08-30 | 湖北省吉美化妆品有限公司 | Have effects that Vitamin K, the plant composition for eye pouch of dispelling and its application in external use skin care |
| CN110585100A (en) * | 2019-10-15 | 2019-12-20 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine composition with moisturizing and anti-aging functions and preparation method and application thereof |
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