CN103860439B - A kind of whitening skin and preserving moisture skin care compositions and preparation method thereof - Google Patents
A kind of whitening skin and preserving moisture skin care compositions and preparation method thereof Download PDFInfo
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- CN103860439B CN103860439B CN201410139278.7A CN201410139278A CN103860439B CN 103860439 B CN103860439 B CN 103860439B CN 201410139278 A CN201410139278 A CN 201410139278A CN 103860439 B CN103860439 B CN 103860439B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention discloses a kind of whitening skin and preserving moisture skin care compositions, belong to cosmetic field, its component is by weight: salvia miltiorrhiza flower a kind of sedge 30-50 part, Pericarpium Citri Reticulatae 20-30 part, Fructus Momordicae 15-25 part, fresh Fructus Mori 10-18 part, Fructus Lycii 5-10 part, the compositions of the present invention have employed five kinds of raw materials as constituent, forming relatively easy, material is prone to obtain, with low cost, and by suitable preparation method, achieve whitening and skin-protecting cooperative synergism effect；The compositions of the present invention has the skin care effect of significant whitening, speckle dispelling, wrinkle removal, moisturizing, the skin that compacts simultaneously；It addition, effectively utilize for salvia miltiorrhiza flower a kind of sedge discarded in a large number, fresh Fructus Mori, it is therefore prevented that the wasting of resources, with low cost, create bigger economic benefit and social benefit.
Description
Technical field
The present invention relates to beauty and skin care technical field, particularly relate to a kind of whitening skin and preserving moisture skin care compositions and preparation method thereof.
Background technology
Along with improving constantly of expanding economy and living standard, beauty and skin care has been had increasingly higher requirement by people；On the other hand, along with the increase of life and work pressure and environmental pollution, also worse and worse, skin is pitch-dark, xerosis cutis, the phenomenon such as intense darkness without light annoying increasing people, especially modern female for skin especially skin of face.
At present, there is the product of various whitening and skin-protecting.The product of a lot of chemical compositions, due to reasons such as its zest, side effect and DeGrains, is applied less.And Chinese herbal medicine is because its composition is natural, and integration of edible and medicinal herbs, no matter as oral administration or external, there is very big advantage as whitening and skin-protecting.A lot of Chinese medicines have the advantage of integration of edible and medicinal herbs, are widely used in slow down aging and skin whitening etc..Such as, the a lot of polyphenoils contained in Fructus Lycii (LyciumbarbarumL.), as vitamin E, vitamin C, carotene, glycine betaine, flavonoid rutin etc., they all can suppress the generation of lipid peroxide well, there is very strong anti-oxidation function, it is possible to play the effect of despeckle skin care, slow down aging.
At present, also having a lot of report that Chinese herbal medicine is used for whitening and skin-protecting, if publication number is the Chinese patent application of 101797208A, and for example publication number is the Chinese patent application of 101744756A.These current reports, often have the shortcoming that constituent is complicated, and the constituent such as the Chinese patent application that publication number is 101744756A reaches 20 kinds more than, and other existing compositionss are also more than at least seven kinds.Specifically, first, the complicated component of Chinese medicine, much important composition is not yet understood completely, too much Chinese medicine mixing, and complex reaction can occur each other, add the uncertain risk of Chinese medicine, particularly with the medicine used for slow down aging and skin whitening or health product, generally require long-term taking, thus adding the risk that the even pathogenic teratogenesis of side reaction is carcinogenic；Secondly, of a great variety, the collection for production cost, raw material also brings difficulty, owes abundant manufacturer particularly with natural resources of Chinese medicinal materials, increases its production cost, directly affects Business Economic Benefit.
It addition, the present report about whitening and skin-protecting, often function singleness, it is impossible to whitening, moisturizing etc. simultaneously；And usage limitation, it is simply possible to use in external or is simply possible to use in for oral administration, effect is also inconspicuous.
Summary of the invention
One of goal of the invention of the present invention, is in that for above-mentioned Problems existing, it is provided that a kind of constituent is simple, with low cost and has the compositions of whitening, moistening effect concurrently.
The technical solution used in the present invention is such that a kind of whitening skin and preserving moisture skin care compositions, and its component is by weight: salvia miltiorrhiza flower a kind of sedge 30-50 part, Pericarpium Citri Reticulatae 20-30 part, Fructus Momordicae 15-25 part, fresh Fructus Mori 10-18 part, Fructus Lycii 5-10 part.
Present inventor is through great many of experiments, adopt salvia miltiorrhiza flower a kind of sedge, Pericarpium Citri Reticulatae, Fructus Momordicae, fresh Fructus Mori and Fructus Lycii as raw material, form new compositions, and determine its suitable proportion, and demonstrate its effect such as whitening, moisturizing, prove that the effects such as its whitening, moisturizing, speckle dispelling are substantially better than at least one effect adopted in fresh Fructus Mori, Fructus Momordicae, Fructus Lycii simultaneously, be namely provided with whitening, moisturizing, the anti-ageing synergistic function waited for a long time owing to have employed following preparation method between the compositions of the present invention.
In the above-mentioned composition of the present invention, labiate Radix Salviae Miltiorrhizae (Salviamiltiorrhiza) is its dry root medicinal mainly, is mainly used in the treatment of cardiovascular disease.In the planting process of Radix Salviae Miltiorrhizae, in order to promote its root growth, it is necessary to colored a kind of sedge that Radix Salviae Miltiorrhizae is extracted out is extractd in time.Often being discarded after excision, especially in Radix Salviae Miltiorrhizae GAP planting base, often discarded substantial amounts of salvia miltiorrhiza flower a kind of sedge, from Chinese medicine point of theory, the salvia miltiorrhiza flower a kind of sedge in above-mentioned composition is as monarch drug.
Pericarpium Citri Reticulatae in above-mentioned composition is the dry mature skin of rutaceae orange (CitrusreticulataBlanco) and variety thereof, and it has regulating qi-flowing for strengthening spleen, in tune, dampness, the effect reduced phlegm, often it is used as medicine, yet there are no for skin care industry, especially as exterior-applied article such as facial film for skin protection.And the present invention adopts it to coordinate with fresh Fructus Mori etc., as ministerial drug.
Fructus Momordicae (Siraitiagrosvenori) in above-mentioned composition is cucurbitaceous plant, its effect having lung moistening, eliminating the phlegm, quench one's thirst, it may have the effect of loosening bowel to relieve constipation.It addition, the mature fruit that Fructus Mori (FructusMori) are Moraceae deciduous tree mulberry.Mulberry is planted in a large number in the rural area bred silkworms, and annual 5-8 month Fructus Mori are ripe, then rural area is often land abandonment after substantial amounts of Fructus Mori maturation.Because of its there is nourishing YIN and supplementing blood, the effect moisturized of promoting the production of body fluid, also have as health food or be used as medicine.In beauty treatment, it has the effect of hair color, but the report as skin protection has no, and in the present compositions, select fresh Fructus Mori as raw material, it may be possible to because fresh Fructus Mori compare the composition drying or adopting the Fructus Mori that other modes dry to have whitening and skin-protecting preferably.And in the present compositions, Fructus Momordicae and Fructus Mori are all as adjuvant drug.
In the present compositions, Fructus Lycii (LyciumbarbarumL.) is mainly used in hepatic and renal YIN deficiency, replenishing vital essence to improve eyesight, also have been reported that Fructus Lycii may be used for whitening anti-aging, and in the present compositions, adopt Fructus Lycii as making medicine, assist other several components for whitening, wrinkle removal, moisturizing and the skin etc. that compacts.
As preferred technical scheme, its component is by weight: salvia miltiorrhiza flower a kind of sedge 35-45 part, Pericarpium Citri Reticulatae 25-28 part, Fructus Momordicae 18-20 part, fresh Fructus Mori 12-15 part, Fructus Lycii 6-8 part.
As it is preferred that technical scheme, its component is by weight: salvia miltiorrhiza flower a kind of sedge 36 parts, Pericarpium Citri Reticulatae 26 parts, Fructus Momordicae 19 parts, fresh Fructus Mori 14 parts, Fructus Lycii 7 parts.
As preferred technical scheme: described fresh Fructus Mori are purpureal ripe mulberry.Such Fructus Mori are preferably for whitening and skin-protecting.
The two of the purpose of the present invention, are in that to provide the application of above-mentioned composition, and the technical scheme of employing is: described compositions is made facial film.
Another kind of application as combinations thereof: described compositions is made oral drugs.
The three of the purpose of the present invention, are in that the preparation method providing a kind of above-mentioned whitening skin and preserving moisture skin care compositions, and the technical scheme of employing is: comprise the following steps,
(1) choose and weigh raw material: choosing the Fructus Mori starting to start at from fructufy 20-50 days, and in the saline solution that mass fraction is 5-10% after immersion 0.5-1, drain to surface moisture naked eyes invisible, obtain fresh Fructus Mori raw material；Choose salvia miltiorrhiza flower a kind of sedge of new excision, dry to surface moisture naked eyes invisible after cleaning with clear water, obtain salvia miltiorrhiza flower a kind of sedge raw material, then choose Pericarpium Citri Reticulatae, Fructus Momordicae and Fructus Lycii, weigh according to described ratio；
(2) comminuted starting materials: the raw material obtained alleged in step (1) is pulverized together；
(3) extract: the raw material after pulverizing in step (2) is joined immersion in the ethanol that volume fraction is 50-70%, and add the acetic acid of raw material and total ethanol quality 1-5%, it is aided with ultrasonic simultaneously, and is heated to 45-50 DEG C and extracts, this process amounts to 2-3h, obtains extracting solution；
(4) filtration drying: the extracting solution of gained in step (3) is filtered, takes liquid portion, carry out lyophilization, to obtain final product.
As preferred technical scheme: the preparation method of described facial film is, on the basis of the compositions made at said method, add the pharmaceutically acceptable adjuvant preparing facial film, to obtain final product.
As preferred technical scheme: the preparation method of described oral drugs is, on the basis of the compositions made at said method, add the pharmaceutically acceptable adjuvant preparing peroral dosage form, to obtain final product.
In sum, owing to have employed technique scheme, the invention has the beneficial effects as follows:
First, have employed five kinds of raw materials as constituent, form relatively easy, material is prone to obtain, with low cost, and by suitable preparation method, achieves whitening and skin-protecting cooperative synergism effect；
Then, the compositions of the present invention has the skin care effect of significant whitening, speckle dispelling, wrinkle removal, moisturizing, the skin that compacts simultaneously；
It addition, effectively utilize for salvia miltiorrhiza flower a kind of sedge discarded in a large number, fresh Fructus Mori, it is therefore prevented that the wasting of resources, with low cost, create bigger economic benefit and social benefit；
Finally, the preparation method of composition of the present invention is simple, it is simple to industrialized production, it is easy to popularization and application.
Detailed description of the invention
The present invention is described in detail below.
In order to make the purpose of the present invention, technical scheme and advantage clearly understand, below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that specific embodiment described herein is only in order to explain the present invention, is not intended to limit the present invention.
Embodiment 1:
A kind of whitening skin and preserving moisture skin care compositions, its component is by weight: salvia miltiorrhiza flower a kind of sedge 30 parts, Pericarpium Citri Reticulatae 20 parts, Fructus Momordicae 15 parts, fresh Fructus Mori 10 parts, Fructus Lycii 5 parts；
Its preparation method is, comprises the following steps,
(1) choose and weigh raw material: choosing the Fructus Mori starting to start at from fructufy 45 days, and in the saline solution that mass fraction is 10% after immersion 0.8h, drain to surface moisture naked eyes invisible, obtain fresh Fructus Mori raw material；Collect the salvia miltiorrhiza flower a kind of sedge after extracing, dry to surface moisture naked eyes invisible after cleaning with clear water, obtain salvia miltiorrhiza flower a kind of sedge raw material, then choose Pericarpium Citri Reticulatae, Fructus Momordicae and Fructus Lycii, weigh according to described ratio；
(2) comminuted starting materials: the raw material obtained alleged in step (1) is pulverized together；
(3) extracting: joined in the ethanol that volume fraction is 60% by the raw material after pulverizing in step (2) and soak, and add the acetic acid of raw material and total ethanol quality 3%, be aided with ultrasonic simultaneously, and be heated to 50 DEG C and extract, this process amounts to 2.5h, obtains extracting solution；
(4) filtration drying: the extracting solution of gained in step (3) is filtered, takes liquid portion, carry out lyophilization, to obtain final product.
It addition, the present embodiment is also by the compositions after above-mentioned lyophilization, adds adjuvant and make tablet or facial film.
Wherein, when making facial film, the adjuvant of addition is propylene glycol, arabic gum and ethyl hydroxybenzoate.
Using method: when making facial film, the compositions after the every facial film above-mentioned lyophilization of load 2g, every day, each use was a piece of sooner or later, applied no less than 20 minutes every time.
Make tablet, every containing the compositions 0.5g after above-mentioned lyophilization, taken three times a day, each take 2.
Situation according to skin, it is possible to external simultaneously and for oral administration or only external or for oral administration.
Embodiment 2:
A kind of whitening skin and preserving moisture skin care compositions, its component is by weight: salvia miltiorrhiza flower a kind of sedge 50 parts, Pericarpium Citri Reticulatae 30 parts, Fructus Momordicae 25 parts, fresh Fructus Mori 18 parts, Fructus Lycii 10 parts.
Preparation method is identical with embodiment 1.
Embodiment 3:
A kind of whitening skin and preserving moisture skin care compositions, its component is by weight: salvia miltiorrhiza flower a kind of sedge 35 parts, Pericarpium Citri Reticulatae 25 parts, Fructus Momordicae 18 parts, fresh Fructus Mori 12 parts, Fructus Lycii 6 parts.
Preparation method is identical with embodiment 1.
Embodiment 4:
A kind of whitening skin and preserving moisture skin care compositions, its component is by weight: salvia miltiorrhiza flower a kind of sedge 45 parts, Pericarpium Citri Reticulatae 28 parts, Fructus Momordicae 20 parts, fresh Fructus Mori 15 parts, Fructus Lycii 8 parts.
Preparation method is identical with embodiment 1.
Embodiment 5:
A kind of whitening skin and preserving moisture skin care compositions, its component is by weight: salvia miltiorrhiza flower a kind of sedge 36 parts, Pericarpium Citri Reticulatae 26 parts, Fructus Momordicae 19 parts, fresh Fructus Mori 14 parts, Fructus Lycii 7 parts.
Preparation method is identical with embodiment 1.
Wherein, when making facial film, the adjuvant of addition is propylene glycol, arabic gum and ethyl hydroxybenzoate.
Using method: when making facial film, the compositions after the every facial film above-mentioned lyophilization of load 2g, every day, each use was a piece of sooner or later, applied no less than 20 minutes every time.
Make tablet, every containing the compositions 0.5g after above-mentioned lyophilization, taken three times a day, each take 2.
Embodiment 6
Suppress the experiment of tyrosinase activity
Skin darkening and the skin problem such as freckle, brown patch are all due to dye.Owing to the main cause of dye is melanin, and suppressing tyrosinase activity is one of the cardinal principle of whitening, speckle dispelling.This experiment suppresses the compositions of experimental verification the application of tyrosinase activity to have the effects such as significant whitening, speckle dispelling on the one hand by mensuration.
1, instrument and reagent
FA1604 electronic analytical balance (the auspicious instrument in Shanghai side)
UVB500 ultraviolet-uisible spectrophotometer (Shanghai unit analyzer device)
Tryrosinase, arbutin are purchased from Jiang Lai bio tech ltd, Shanghai.
2, sample
Adopt the compositions obtained by the embodiment of the present invention 3 as test specimen.
3, method of testing
Take four test tubes and put on No. 1, No. 2, No. 3, No. 4 respectively；Reagent dosage and concentration with reference to table 1, the respective reaction liquid listed by each row it is separately added in four test tubes, jolting is mixed evenly, 10min is preheated in 37oC, then in each test tube, it is separately added into tyrosinase solution, in 37oC accurate response 5min, it is transferred quickly in cuvette, surveys absorbance (A) in 475nm place；
4, result calculates and statistics
It is calculated as follows the suppression ratio to tryrosinase:
Suppression ratio=[1-(A3-A4)/(A1-A2)] × 100%
In formula: A1, A2, A3, A4 represent absorbance measured in 475nm place after reaction in No. 1, No. 2, No. 3, No. 4 four test tubes in table 1 respectively.
Table 1: the composition (unit: ml) of liquid to be measured
To cause that the inhibitor concentration (IC50) of tryrosinase vigor decline 50% characterizes effect of inhibitor.Suppress tyrosinase activity testing result in Table 2.
Table 2: each sample suppresses tyrosinase activity testing result
Result above shows that the compositions of the embodiment of the present invention 3 has stronger tyrosinase activity rejection ability, and its activity is better than arbutin.
Meanwhile, contrast experiment has been carried out
The laboratory sample that this contrast experiment adopts is as follows: (ratio is mass ratio), the quality of each sample of employing is equal
Salvia miltiorrhiza flower a kind of sedge 36 parts, Pericarpium Citri Reticulatae 26 parts, Fructus Momordicae 19 parts, fresh Fructus Mori 14 parts, Fructus Lycii 7 parts
No. 1: salvia miltiorrhiza flower a kind of sedge；No. 2: Pericarpium Citri Reticulatae；No. 3: Fructus Momordicae；No. 4: fresh Fructus Mori；No. 5: Fructus Lycii；No. 6: Fructus Lycii+Fructus Momordicae (1:1)；No. 7: fresh Fructus Mori+Fructus Lycii (1:1)；No. 8: fresh Fructus Mori+Fructus Lycii+Fructus Momordicae (1:1:1)；No. 9: the compositions of embodiment 1；No. 10: the compositions of embodiment 2；No. 11: the compositions of embodiment 4；No. 12: the compositions of embodiment 5；
Adopting said method to test, experimental result is table 3 such as:
Table 3: each sample suppresses tyrosinase activity testing result (unit: mg/ml)
Embodiment 7
The removing of DPPH free radical is tested
1. instrument and reagent
FA1604 electronic analytical balance (the auspicious instrument in Shanghai side)
UVB500 ultraviolet-uisible spectrophotometer (Shanghai unit analyzer device)
Free radical (DPPH), arbutin are purchased from Jiang Lai bio tech ltd, Shanghai, and ethanol is purchased from Kingsoft, Chengdu reagent company limited.
2. sample
Adopt the compositions obtained by the embodiment of the present invention 3 as test specimen；
3. non-oxidizability experiment
The removing of DPPH free radical is tested by 3.1 samples
The preparation of DPPH solution:
Accurately weighing DPPH7.88mg, be placed in 100ml volumetric flask, with anhydrous alcohol solution to scale, obtain the DPPH solution that concentration is 2 × 10-4mo1/l, keep in Dark Place (0～4 DEG C)；
The preparation of test liquid:
Take the extracting solution 40ml of the compositions of the present invention, be placed in 200ml volumetric flask, with ethanol dilution to scale；
Assay method:
Separately sampled product solution 5ml and 2 × 10-4mo1/lDPPH solution 5ml Homogeneous phase mixing, places 30min in the dark, and with methanol for blank in 525nm place its absorbance A of mensuration, and below formula calculates its clearance rate:
Clearance rate (%)=1-(Ai-Aj)/Ac ］ × 100%
In formula: Ac:5ml ethanol adds the absorbance of 5mlDPPH solution；
Ai:5ml liquid to be measured adds the absorbance of 5mlDPPH solution；
Aj:5ml liquid to be measured adds the absorbance of 5ml ethanol；
Clearance rate is calculated according to formula above.
Activity concentration (IC50) to remove DPPH free radical 50% characterizes effect of free radical scavenger.Radical scavenging activities testing result is in Table 4.
Table 4: each sample radical scavenging activities testing result
Result shows that the compositions extracting solution of the present invention has stronger DPPH radical scavenging activity, and its activity is better than arbutin.
The laboratory sample that this contrast experiment adopts is as follows: (ratio is mass ratio), the quality of each sample of employing is equal
Salvia miltiorrhiza flower a kind of sedge 36 parts, Pericarpium Citri Reticulatae 26 parts, Fructus Momordicae 19 parts, fresh Fructus Mori 14 parts, Fructus Lycii 7 parts
No. 1: salvia miltiorrhiza flower a kind of sedge；No. 2: Pericarpium Citri Reticulatae；No. 3: Fructus Momordicae；No. 4: fresh Fructus Mori；No. 5: Fructus Lycii；No. 6: Fructus Lycii+Fructus Momordicae (1:1)；No. 7: fresh Fructus Mori+Fructus Lycii (1:1)；No. 8: fresh Fructus Mori+Fructus Lycii+Fructus Momordicae (1:1:1)；No. 9: the compositions of embodiment 1；No. 10: the compositions of embodiment 2；No. 11: the compositions of embodiment 4；No. 12: the compositions of embodiment 5；
Adopting said method to test, experimental result is table 5 such as:
Table 5: each sample suppresses tyrosine activity testing result (unit: μ g/ml)
Above-mentioned experiment proves that the compositions of the present invention achieves unexpected excellent whitening, freckle effect.
Embodiment 8
Whitening moisturizing clinical experiment
1, experimental subject:
Choose experimenter 160, women, the age 18-30 year between, and living habit be stay up late for a long time, long-time in the face of computer, skin exist skin of face in various degree dry, dull pitch-dark, be randomly divided into four groups, often organize 40 people,
2, laboratory sample and experimental technique
First group of employing " U.S. is namely " whitening and moisturizing facial film, every day is sooner or later respectively once；The facial film that second group of compositions adopting the embodiment of the present invention 1 is made, every day is sooner or later respectively once；The facial film that the 3rd group of compositions adopting the embodiment of the present invention 5 is made, every day is sooner or later respectively once；The 4th group of facial film made only with the compositions of embodiment 5 for first day, sooner or later respectively once, the tablet that the compositions taking embodiment 5 in second day is made, morning, noon and afternoon every day are each once, so replace；
Experimental period: 30 days
3, detecting instrument:
Skinanalysis apparatus (Korea S EHANG, EH-990U), for detecting moisture change and the melanin situation of change of skin
4, experimental result standard:
Effective: moisture value is between 40-50%, and melanin value is lower than 20
Effective: moisture value is between 20-30%, and melanin value is 20-30
Invalid: moisture value is lower than 20%, and melanin value is more than 30
5, experimental result: as shown in table 6
Table 6 whitening moisturizing clinical trial results (numerical value unit: people)
As can be seen from Table 6, the whitening skin and preserving moisture effect of the compositions of the present invention is notable, and adopts external application and mode for oral administration, and effect is more excellent.
Embodiment 9
Skin elasticity, the colour of skin, wrinkle clinical experiment
Choose 20 ages women in 35-45 year, there is the symptoms such as poor flexibility in various degree, colour of skin dimness, wrinkle in its skin, it is allowed to use the facial film that the compositions of the embodiment of the present invention 5 is made, every day is sooner or later respectively once, skin elasticity is tested with Germany CK company skin elasticity tester MPA580, test the depth of the wrinkle of skin with the skin microscope of Shang Hai optical instrument factory, measure skin brightness change with Delfin skin brightness tester SkinGlossMeter.
As a result, from the 5th day of experimenter's use, the skin of 18 experimenters can detect that brightness increase in various degree, melanin decline；From the 12nd day, the skin of whole 19 experimenters can detect it is elastic enhancing in various degree, and wrinkle shoals.25th day, the brightness of the skin of whole 20 experimenters increased substantially, bright shining coloured silk；30th day, the skin elasticity of whole 20 experimenters was remarkably reinforced, and wrinkle detail shoals.
Claims (3)
1. a whitening skin and preserving moisture skin care compositions, it is characterised in that its starting components is by weight: salvia miltiorrhiza flower a kind of sedge 30-50 part, Pericarpium Citri Reticulatae 20-30 part, Fructus Momordicae 15-25 part, fresh Fructus Mori 10-18 part, Fructus Lycii 5-10 part；
Its preparation method is: comprise the following steps,
(1) choose and weigh raw material: choosing the Fructus Mori starting to start at from fructufy 20-50 days, and in the saline solution that mass fraction is 5-10% after immersion 0.5-1h, drain to surface moisture naked eyes invisible, obtain fresh Fructus Mori raw material；Collect the salvia miltiorrhiza flower a kind of sedge after extracing, dry to surface moisture naked eyes invisible after cleaning with clear water, obtain salvia miltiorrhiza flower a kind of sedge raw material, then choose Pericarpium Citri Reticulatae, Fructus Momordicae and Fructus Lycii, weigh according to described ratio；
(2) comminuted starting materials: the raw material obtained alleged in step (1) is pulverized together；
(3) extract: the raw material after pulverizing in step (2) is joined immersion in the ethanol that volume fraction is 50-70%, and add the acetic acid of raw material and total ethanol quality 1-5%, it is aided with ultrasonic simultaneously, and is heated to 45-50 DEG C and extracts, this process amounts to 2-3h, obtains extracting solution；
(4) filtration drying: the extracting solution of gained in step (3) is filtered, takes liquid portion, carry out lyophilization, to obtain final product.
2. whitening skin and preserving moisture skin care compositions according to claim 1, it is characterised in that its component is by weight: salvia miltiorrhiza flower a kind of sedge 35-45 part, Pericarpium Citri Reticulatae 25-28 part, Fructus Momordicae 18-20 part, fresh Fructus Mori 12-15 part, Fructus Lycii 6-8 part.
3. whitening skin and preserving moisture skin care compositions according to claim 2, it is characterised in that: described fresh Fructus Mori are purpureal ripe mulberry.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510746155.4A CN105232776A (en) | 2014-04-09 | 2014-04-09 | Oral preparation for whitening, moisturizing and skin caring |
| CN201510745801.5A CN105326686B (en) | 2014-04-09 | 2014-04-09 | A kind of skin whitening, moisturizing facial treatment mask |
| CN201410139278.7A CN103860439B (en) | 2014-04-09 | 2014-04-09 | A kind of whitening skin and preserving moisture skin care compositions and preparation method thereof |
| CN201510745954.XA CN105232399B (en) | 2014-04-09 | 2014-04-09 | A kind of preparation method of skin whitening, moisturizing skin care compositions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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| CN201510746155.4A Division CN105232776A (en) | 2014-04-09 | 2014-04-09 | Oral preparation for whitening, moisturizing and skin caring |
| CN201510745801.5A Division CN105326686B (en) | 2014-04-09 | 2014-04-09 | A kind of skin whitening, moisturizing facial treatment mask |
| CN201510745954.XA Division CN105232399B (en) | 2014-04-09 | 2014-04-09 | A kind of preparation method of skin whitening, moisturizing skin care compositions |
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| CN103860439B true CN103860439B (en) | 2016-06-29 |
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| CN201510745801.5A Active CN105326686B (en) | 2014-04-09 | 2014-04-09 | A kind of skin whitening, moisturizing facial treatment mask |
| CN201410139278.7A Active CN103860439B (en) | 2014-04-09 | 2014-04-09 | A kind of whitening skin and preserving moisture skin care compositions and preparation method thereof |
| CN201510746155.4A Pending CN105232776A (en) | 2014-04-09 | 2014-04-09 | Oral preparation for whitening, moisturizing and skin caring |
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| CN201510745801.5A Active CN105326686B (en) | 2014-04-09 | 2014-04-09 | A kind of skin whitening, moisturizing facial treatment mask |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106174578A (en) * | 2015-08-21 | 2016-12-07 | 赵月 | Blood fat reducing beauty-care capsule |
| CN105380843A (en) * | 2015-11-18 | 2016-03-09 | 中山市艾丽意素生物科技有限公司 | Natural plant hydrating lotion and preparation method thereof |
| CN107616502A (en) * | 2017-09-20 | 2018-01-23 | 北京军秀咨询有限公司 | A kind of cosmetic slimming nutrition and health care capsule |
| CN107951778B (en) * | 2017-12-22 | 2021-06-04 | 福建中医药大学 | Shower gel composition and preparation method thereof |
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| JP4754671B2 (en) * | 1999-11-30 | 2011-08-24 | 花王株式会社 | Cosmetics |
| JPWO2004007511A1 (en) * | 2002-07-15 | 2005-11-10 | 株式会社ホソダＳｈｃ | Mangosteen extract |
| JP2008106025A (en) * | 2006-10-23 | 2008-05-08 | Up Great:Kk | Cosmetic |
| CN103027860A (en) * | 2011-09-29 | 2013-04-10 | 庞来祥 | Wolfberry nourishing sleeping mask and preparation method thereof |
| CN102366478B (en) * | 2011-11-14 | 2013-04-03 | 四川逢春制药有限公司 | Composition for whitening skin and resisting senescence, preparation method and application thereof |
| CN102793642B (en) * | 2012-08-28 | 2014-01-15 | 广州丹奇日用化工厂有限公司 | Skin care product composition |
| CN102846520A (en) * | 2012-08-31 | 2013-01-02 | 青岛康泰鑫环保科技有限公司 | Oil-controlling facial cleanser |
| CN103263536A (en) * | 2013-02-04 | 2013-08-28 | 四川逢春制药有限公司 | Skin-whitening freckle-removing anti-aging composite and preparation method and application thereof |
| CN103316150B (en) * | 2013-06-21 | 2015-06-03 | 四川逢春制药有限公司 | Composition for preventing aging and whitening skin as well as preparation method and application thereof |
| CN103599424B (en) * | 2013-10-21 | 2015-09-02 | 张霞 | A kind of Chinese medicine composition for skin whitening |
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| CN105326686B (en) | 2018-02-09 |
| CN103860439A (en) | 2014-06-18 |
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| CN105232776A (en) | 2016-01-13 |
| CN105232399A (en) | 2016-01-13 |
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Effective date of registration: 20160511 Address after: 200444 Shanghai city Baoshan District Fengxiang Road No. 2000 Applicant after: Shanghai Life-Beauty Cosmetics Co., Ltd. Address before: 610066 Sichuan city of Chengdu province Jinjiang District Temple Road No. 22 Building 1, unit 5, No. 505 Applicant before: Zhao Yue |
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