CN103860439A - Whitening and moisturizing skin-care composition and preparation method thereof - Google Patents
Whitening and moisturizing skin-care composition and preparation method thereof Download PDFInfo
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- CN103860439A CN103860439A CN201410139278.7A CN201410139278A CN103860439A CN 103860439 A CN103860439 A CN 103860439A CN 201410139278 A CN201410139278 A CN 201410139278A CN 103860439 A CN103860439 A CN 103860439A
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a whitening and moisturizing skin-care composition, and belongs to the field of cosmetics. The composition comprises the following components in parts by weight: 30-50 parts of salvia miltiorrhiza seed stalk, 20-30 parts of dried tangerine peel, 15-25 parts of momordica grosvenori, 10-18 parts of fresh mulberry and 5-10 parts of medlar. According to the composition, five raw materials are adopted as ingredients, the ingredients are relatively simple, the materials can be easily obtained at low prices, and a synergetic effect of whitening and skin-protecting can be achieved by the proper preparation method. The composition has remarkable skin-care effects of whitening, spot-removing, moistening and skin-firming; furthermore, massive waste salvia miltiorrhiza seed stalk and fresh mulberry can be effective utilized, so that resource waste can be prevented, cost is low, and great economic benefit and social benefit can be generated.
Description
Technical field
The present invention relates to beauty and skin care technical field, relate in particular to a kind of whitening skin and preserving moisture skin care compositions and preparation method thereof.
Background technology
Along with improving constantly of expanding economy and living standard, people have had more and more higher requirement to beauty and skin care; On the other hand, along with the increase of life and work pressure and environmental pollution, skin especially skin of face also worse and worse, skin is pitch-dark, xerosis cutis, the phenomenon such as intense darkness without light are perplexing increasing people, especially modern female.
At present, there is the product of various whitening and skin-protectings.The product of a lot of chemical compositions, due to reasons such as its zest, side effect and DeGrains, is applied less.And Chinese herbal medicine is natural because of its composition, and integration of edible and medicinal herbs, no matter as for oral administration or external, there is very large advantage as whitening and skin-protecting.A lot of Chinese medicines have the advantage of integration of edible and medicinal herbs, are widely used in slow down aging and skin whitening etc.Such as, Fructus Lycii (
lycium barbarum L.) in a lot of polyphenoils of containing, as rutin of vitamin E, vitamin C, carotene, betanin, flavonoid etc., they all can suppress the generation of lipid peroxide well, have very strong anti-oxidation function, can play the effect of speckle skin care, slow down aging.
At present, also have a lot of by Chinese herbal medicine the report for whitening and skin-protecting, as publication number be 101797208A Chinese patent application, the Chinese patent application that and for example publication number is 101744756A.These current reports, often have the shortcoming of constituent complexity, and as the constituent of the publication number Chinese patent application that is 101744756A reaches 20 kinds more than, other existing compositionss are also more than at least seven kinds.Particularly, first, the complicated component of Chinese medicine, much important compositions are understood not yet completely, and too much Chinese medicine mixes, and complex reaction can occur each other, increase the uncertain risk of Chinese medicine, especially for medicine or health product for slow down aging and skin whitening use, often need long-term taking, thereby increased the even pathogenic carcinogenic risk of teratogenesis of side reaction; Secondly, of a great variety, also bring difficulty for the collection of production cost, raw material, especially owe abundant manufacturer for natural resources of Chinese medicinal materials, increase its production cost, directly affect Business Economic Benefit.
In addition, the present report about whitening and skin-protecting, often function singleness, whitening simultaneously, moisturizing etc.; And usage limitation, only can be used for external or only can be used for taking orally, effect is also not obvious.
Summary of the invention
One of goal of the invention of the present invention, is the problem for above-mentioned existence, provides a kind of constituent simple, with low cost and have the compositions of whitening, moistening effect concurrently.
The technical solution used in the present invention is such: a kind of whitening skin and preserving moisture skin care compositions, its component is by weight: salvia miltiorrhiza flower a kind of sedge 30-50 part, Pericarpium Citri Reticulatae 20-30 part, Fructus Momordicae 15-25 part, fresh Fructus Mori 10-18 part, Fructus Lycii 5-10 part.
Present inventor is through great many of experiments, adopt salvia miltiorrhiza flower a kind of sedge, Pericarpium Citri Reticulatae, Fructus Momordicae, fresh Fructus Mori and Fructus Lycii as raw material, form new compositions, and determine the proportion that it is suitable, and its whitening, moisturizing texts are verified, prove that its whitening, moisturizing, speckle dispelling texts are obviously better than adopting at least one the effect in fresh Fructus Mori, Fructus Momordicae, Fructus Lycii simultaneously, between compositions of the present invention owing to having adopted following preparation method to there is whitening, moisturizing, anti-ageing synergistic function of waiting for a long time.
In above-mentioned composition of the present invention, labiate Radix Salviae Miltiorrhizae (Salvia miltiorrhiza) is medicinal its dry root mainly, is mainly used in the treatment of cardiovascular disease.In the planting process of Radix Salviae Miltiorrhizae, in order to promote its root growth, the colored a kind of sedge that need to extract out Radix Salviae Miltiorrhizae is extractd in time.After excision, often discarded, especially in Radix Salviae Miltiorrhizae GAP planting base, often discarded a large amount of salvia miltiorrhiza flower a kind of sedge, from Chinese medicine point of theory, the salvia miltiorrhiza flower a kind of sedge in above-mentioned composition is as monarch drug.
Pericarpium Citri Reticulatae in above-mentioned composition is the dry mature skin of rutaceae orange (Citrus reticulata Blanco) and variety thereof, it has regulating qi-flowing for strengthening spleen, in tune, dampness, the effect of reducing phlegm, often be used as medicine, yet there are no for skin protection field, especially as exterior-applied article such as facial film is for skin protection.And the present invention adopts it to coordinate with fresh Fructus Mori etc., as ministerial drug.
Fructus Momordicae (Siraitia grosvenori) in above-mentioned composition is cucurbitaceous plant, and the effect that it has lung moistening, eliminates the phlegm, quenches one's thirst, also has the effect of loosening bowel to relieve constipation.In addition, Fructus Mori (Fructus Mori) are the mature fruit of Moraceae deciduous tree mulberry.Mulberry is planted in a large number in the rural area of breeding silkworms, annual 5-8 month Fructus Mori maturation, then rural area is landed abandonment often after a large amount of Fructus Mori maturation.Because of its effect that there is nourishing YIN and supplementing blood, promotes the production of body fluid and moisturize, also have as health food or be used as medicine.Aspect beauty treatment, it has the effect of hair color, but has no as the report of skin protection, and in compositions of the present invention, selecting fresh Fructus Mori as raw material, may be because fresh Fructus Mori are compared and dried or adopt the dry Fructus Mori of other modes to have the composition of whitening and skin-protecting preferably.And in compositions of the present invention, Fructus Momordicae and Fructus Mori are all as adjuvant drug.
In compositions of the present invention, Fructus Lycii (Lycium barbarum L.) is mainly used in hepatic and renal YIN deficiency, replenishing vital essence to improve eyesight, also have report Fructus Lycii can be for whitening anti-aging, and in compositions of the present invention, adopt Fructus Lycii as making medicine, auxiliary other several components are for whitening, wrinkle removal, moisturizing and the skin etc. that compacts.
As preferred technical scheme, its component is by weight: salvia miltiorrhiza flower a kind of sedge 35-45 part, Pericarpium Citri Reticulatae 25-28 part, Fructus Momordicae 18-20 part, fresh Fructus Mori 12-15 part, Fructus Lycii 6-8 part.
As further preferred technical scheme, its component is by weight: 36 parts of salvia miltiorrhiza flower a kind of sedges, 26 parts of Pericarpium Citri Reticulataes, 19 parts of Fructus Momordicaes, 14 parts of fresh Fructus Mori, 7 parts of Fructus Lyciis.
As preferred technical scheme: described fresh Fructus Mori are purpureal ripe mulberry.Such Fructus Mori are preferably for whitening and skin-protecting.
Two of object of the present invention, is to provide the application of above-mentioned composition, and the technical scheme of employing is: described compositions is made to facial film.
Another kind application as combinations thereof: described compositions is made to oral drugs.
Three of object of the present invention, is to provide a kind of preparation method of above-mentioned whitening skin and preserving moisture skin care compositions, and the technical scheme of employing is: comprise the following steps,
(1) choose and weighing raw materials: choose from fructufy and start to start at the Fructus Mori of 20-50 days, and soak after 0.5-1 in the saline solution that is 5-10% at mass fraction, drain to surface moisture naked eyes invisiblely, obtain fresh Fructus Mori raw material; Choose salvia miltiorrhiza flower a kind of sedge of new excision, after cleaning with clear water, dry to surface moisture naked eyes invisiblely, obtain salvia miltiorrhiza flower a kind of sedge raw material, then choose Pericarpium Citri Reticulatae, Fructus Momordicae and Fructus Lycii, weigh according to described ratio;
(2) comminuted starting materials: the alleged raw material obtaining in step (1) is pulverized together;
(3) extract: the raw material after pulverizing in step (2) is joined in the ethanol that volume fraction is 50-70% and soaked, and add the acetic acid of raw material and total ethanol quality 1-5%, and be aided with ultrasonicly simultaneously, and be heated to 45-50 ℃ and extract, this process amounts to 2-3h, obtains extracting solution;
(4) filtration drying: the extracting solution of gained in step (3) is filtered, get liquid part, carry out lyophilization, to obtain final product.
As preferred technical scheme: the preparation method of described facial film is, on the basis of the compositions of making at said method, add the pharmaceutically acceptable adjuvant of preparing facial film, to obtain final product.
As preferred technical scheme: the preparation method of described oral drugs is, on the basis of the compositions of making at said method, add the pharmaceutically acceptable adjuvant of preparing peroral dosage form, to obtain final product.
In sum, owing to having adopted technique scheme, the invention has the beneficial effects as follows:
First, adopted five kinds of raw materials as constituent, formed relatively simply, material is easy to obtain, with low cost, and by suitable preparation method, has obtained whitening and skin-protecting cooperative synergism effect;
Then, compositions of the present invention has the skin care effect of significant whitening, speckle dispelling, wrinkle removal, moisturizing, the skin that compacts simultaneously;
In addition, effectively utilize for a large amount of discarded salvia miltiorrhiza flower a kind of sedge, fresh Fructus Mori, prevented the wasting of resources, with low cost, produce larger economic benefit and social benefit;
Finally, preparation method of composition of the present invention is simple, is convenient to suitability for industrialized production, is easy to apply.
The specific embodiment
The present invention is described in detail below.
In order to make object of the present invention, technical scheme and advantage clearer, below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not intended to limit the present invention.
Embodiment 1:
A kind of whitening skin and preserving moisture skin care compositions, its component is by weight: 30 parts of salvia miltiorrhiza flower a kind of sedges, 20 parts of Pericarpium Citri Reticulataes, 15 parts of Fructus Momordicaes, 10 parts of fresh Fructus Mori, 5 parts of Fructus Lyciis;
Its preparation method is, comprises the following steps,
(1) choose and weighing raw materials: choose from fructufy and start to start at the Fructus Mori of 45 days, and soak after 0.8h in the saline solution that is 10% at mass fraction, drain to surface moisture naked eyes invisiblely, obtain fresh Fructus Mori raw material; Collect the salvia miltiorrhiza flower a kind of sedge after extracing, after cleaning with clear water, dry to surface moisture naked eyes invisiblely, obtain salvia miltiorrhiza flower a kind of sedge raw material, then choose Pericarpium Citri Reticulatae, Fructus Momordicae and Fructus Lycii, weigh according to described ratio;
(2) comminuted starting materials: the alleged raw material obtaining in step (1) is pulverized together;
(3) extract: it is to soak in 60% ethanol that the raw material after pulverizing in step (2) is joined to volume fraction, and adds the acetic acid of raw material and total ethanol quality 3%, be aided with ultrasonicly simultaneously, and be heated to 50 ℃ and extract, this process amounts to 2.5h, obtains extracting solution;
(4) filtration drying: the extracting solution of gained in step (3) is filtered, get liquid part, carry out lyophilization, to obtain final product.
In addition, the present embodiment, also by the compositions after above-mentioned lyophilization, adds adjuvant to make tablet or facial film.
Wherein, while making facial film, the adjuvant adding is propylene glycol, arabic gum and ethyl hydroxybenzoate.
Using method: while making facial film, the compositions after the above-mentioned lyophilization of every facial film load 2g, every day is each a slice that uses sooner or later, and each applying is no less than 20 minutes.
Make tablet, every containing the compositions 0.5g after above-mentioned lyophilization, taken three times a day, each serving with 2.
According to the situation of skin, external simultaneously and for oral administration or only external or for oral administration.
Embodiment 2:
A kind of whitening skin and preserving moisture skin care compositions, its component is by weight: 50 parts of salvia miltiorrhiza flower a kind of sedges, 30 parts of Pericarpium Citri Reticulataes, 25 parts of Fructus Momordicaes, 18 parts of fresh Fructus Mori, 10 parts of Fructus Lyciis.
Preparation method is identical with embodiment 1.
Embodiment 3:
A kind of whitening skin and preserving moisture skin care compositions, its component is by weight: 35 parts of salvia miltiorrhiza flower a kind of sedges, 25 parts of Pericarpium Citri Reticulataes, 18 parts of Fructus Momordicaes, 12 parts of fresh Fructus Mori, 6 parts of Fructus Lyciis.
Preparation method is identical with embodiment 1.
Embodiment 4:
A kind of whitening skin and preserving moisture skin care compositions, its component is by weight: 45 parts of salvia miltiorrhiza flower a kind of sedges, 28 parts of Pericarpium Citri Reticulataes, 20 parts of Fructus Momordicaes, 15 parts of fresh Fructus Mori, 8 parts of Fructus Lyciis.
Preparation method is identical with embodiment 1.
Embodiment 5:
A kind of whitening skin and preserving moisture skin care compositions, its component is by weight: 36 parts of salvia miltiorrhiza flower a kind of sedges, 26 parts of Pericarpium Citri Reticulataes, 19 parts of Fructus Momordicaes, 14 parts of fresh Fructus Mori, 7 parts of Fructus Lyciis.
Preparation method is identical with embodiment 1.
Wherein, while making facial film, the adjuvant adding is propylene glycol, arabic gum and ethyl hydroxybenzoate.
Using method: while making facial film, the compositions after the above-mentioned lyophilization of every facial film load 2g, every day is each a slice that uses sooner or later, and each applying is no less than 20 minutes.
Make tablet, every containing the compositions 0.5g after above-mentioned lyophilization, taken three times a day, each serving with 2.
Embodiment 6
The experiment of restraint of tyrosinase activity
The skin problems such as skin darkening and freckle, brown patch are all due to dye.Because the main cause of dye is melanin, and restraint of tyrosinase activity is one of cardinal principle of whitening, speckle dispelling.This experiment one side has the effects such as significant whitening, speckle dispelling by experimental verification the application's of mensuration restraint of tyrosinase activity compositions.
1, instrument and reagent
FA1604 electronic analytical balance (the auspicious instrument in Shanghai side)
UVB500 ultraviolet-uisible spectrophotometer (instrument is analysed by Shanghai unit)
Tryrosinase, arbutin are purchased from Jiang Lai bio tech ltd, Shanghai.
2, sample
Adopt the prepared compositions of the embodiment of the present invention 3 as test specimen.
3, method of testing
Getting four test tubes puts on respectively No. 1, No. 2, No. 3, No. 4; With reference to reagent dosage and the concentration of table 1, in vitro add respectively the listed respective reaction liquid of each row at four, jolting is mixed evenly, in 37oC preheating 10min, then respectively in vitro adding respectively tryrosinase solution, in 37oC accurate response 5min, be transferred to rapidly in cuvette, survey absorbance (A) in 475nm place;
4, result is calculated and statistics
Be calculated as follows the suppression ratio to tryrosinase:
Suppression ratio=[1-(A3-A4)/(A1-A2)] × 100%
In formula: A1, A2, A3, A4 represent respectively the absorbance recording in 475nm place after reaction in No. 1, No. 2, No. 3, No. 4 four test tubes in table 1.
Table 1: the composition (unit: ml) of liquid to be measured
To cause the inhibitor concentration (IC50) of tryrosinase vigor decline 50% to characterize effect of inhibitor.The active testing result of restraint of tyrosinase is in table 2.
Table 2: the active testing result of each sample restraint of tyrosinase
Above result shows that the compositions of the embodiment of the present invention 3 has stronger tyrosinase activity to suppress ability, and its activity is better than arbutin.
Meanwhile, carried out contrast experiment
The laboratory sample that this contrast experiment adopts is as follows: (ratio is mass ratio), the quality of each sample of employing equates
36 parts of salvia miltiorrhiza flower a kind of sedges, 26 parts of Pericarpium Citri Reticulataes, 19 parts of Fructus Momordicaes, 14 parts of fresh Fructus Mori, 7 parts of Fructus Lyciis
No. 1: salvia miltiorrhiza flower a kind of sedge; No. 2: Pericarpium Citri Reticulatae; No. 3: Fructus Momordicae; No. 4: fresh Fructus Mori; No. 5: Fructus Lycii; No. 6: Fructus Lycii+Fructus Momordicae (1:1); No. 7: fresh Fructus Mori+Fructus Lycii (1:1); No. 8: fresh Fructus Mori+Fructus Lycii+Fructus Momordicae (1:1:1); No. 9: the compositions of embodiment 1; No. 10: the compositions of embodiment 2; No. 11: the compositions of embodiment 4; No. 12: the compositions of embodiment 5;
Adopt said method to test, experimental result is as table 3:
Table 3: the active testing result of each sample restraint of tyrosinase (unit: mg/ml)
Embodiment 7
To the removing experiment of DPPH free radical
1. instrument and reagent
FA1604 electronic analytical balance (the auspicious instrument in Shanghai side)
UVB500 ultraviolet-uisible spectrophotometer (instrument is analysed by Shanghai unit)
Free radical (DPPH), arbutin are purchased from Jiang Lai bio tech ltd, Shanghai, and ethanol is purchased from Kingsoft, Chengdu reagent company limited.
2. sample
Adopt the prepared compositions of the embodiment of the present invention 3 as test specimen;
3. non-oxidizability experiment
The removing experiment of 3.1 samples to DPPH free radical
The preparation of DPPH solution:
Accurately take DPPH7.88mg, be placed in 100ml volumetric flask, with anhydrous alcohol solution, to scale, obtaining concentration is the DPPH solution of 2 × 10-4mo1/l, and (0～4 ℃) keeps in Dark Place;
The preparation of test liquid:
The extracting solution 40ml that gets compositions of the present invention, is placed in 200ml volumetric flask, with ethanol dilution to scale;
Assay method:
Extracting sample solution 5ml evenly mixes with 2 × 10-4mo1/l DPPH solution 5ml respectively, places in the dark 30min, measures its absorbance A, and calculate its clearance rate with following formula take methanol as blank at 525nm place:
Clearance rate (%)=and 1-(Ai-Aj)/Ac ］ × 100%
In formula: Ac:5ml ethanol adds the absorbance of 5mlDPPH solution;
Ai:5ml liquid to be measured adds the absorbance of 5mlDPPH solution;
Aj:5ml liquid to be measured adds the absorbance of 5ml ethanol;
According to the clearance rate of formula calculating above.
Characterize effect of free radical scavenger to remove the activity concentration (IC50) of DPPH free radical 50%.Radical scavenging activities testing result is in table 4.
Table 4: each sample radical scavenging activities testing result
Result shows that compositions extracting solution of the present invention has stronger DPPH radical scavenging activity, and its activity is better than arbutin.
The laboratory sample that this contrast experiment adopts is as follows: (ratio is mass ratio), the quality of each sample of employing equates
36 parts of salvia miltiorrhiza flower a kind of sedges, 26 parts of Pericarpium Citri Reticulataes, 19 parts of Fructus Momordicaes, 14 parts of fresh Fructus Mori, 7 parts of Fructus Lyciis
No. 1: salvia miltiorrhiza flower a kind of sedge; No. 2: Pericarpium Citri Reticulatae; No. 3: Fructus Momordicae; No. 4: fresh Fructus Mori; No. 5: Fructus Lycii; No. 6: Fructus Lycii+Fructus Momordicae (1:1); No. 7: fresh Fructus Mori+Fructus Lycii (1:1); No. 8: fresh Fructus Mori+Fructus Lycii+Fructus Momordicae (1:1:1); No. 9: the compositions of embodiment 1; No. 10: the compositions of embodiment 2; No. 11: the compositions of embodiment 4; No. 12: the compositions of embodiment 5;
Adopt said method to test, experimental result is as table 5:
Table 5: each sample suppresses the active testing result of tyrosine (unit: μ g/ml)
Above-mentionedly experimental results show that compositions of the present invention has obtained unexpected excellent whitening, freckle effect.
Embodiment 8
Whitening moisturizing clinical experiment
1, experimental subject:
Choose 160 of experimenters, women, the age is between 18-30 year, and living habit be for a long time stay up late, for a long time in the face of computer, skin exists that skin of face is in various degree dry, dimness is pitch-dark, is divided at random four groups, every group of 40 people,
2, laboratory sample and experimental technique
First group of employing " beautiful " whitening and moisturizing facial film, every day is sooner or later respectively once; Second group of facial film that adopts the compositions of the embodiment of the present invention 1 to make, every day is sooner or later respectively once; The 3rd group of facial film that adopts the compositions of the embodiment of the present invention 5 to make, every day is sooner or later respectively once; The 4th group of facial film that first day only adopts the compositions of embodiment 5 to make, sooner or later respectively once, takes the tablet that the compositions of embodiment 5 is made for second day, and morning, noon and afternoon every day respectively once, so replace;
Experimental period: 30 days
3, detecting instrument:
Skinanalysis apparatus (Korea S EHANG, EH-990U), changes and melanin situation of change for detection of the moisture of skin
4, experimental result standard:
Effective: moisture value is between 40-50%, and melanin value is lower than 20
Effective: moisture value is between 20-30%, and melanin value is 20-30
Invalid: moisture value is lower than 20%, and melanin value is more than 30
5, experimental result: as shown in table 6
Table 6 whitening moisturizing clinical experiment result (numerical value unit: people)
As can be seen from Table 6, the whitening skin and preserving moisture effect of compositions of the present invention is remarkable, and adopts external application and mode for oral administration, and effect is more excellent.
Embodiment 9
Skin elasticity, the colour of skin, wrinkle clinical experiment
Choose 20 ages in the 35-45 women in year, there is the symptoms such as poor flexibility in various degree, colour of skin dimness, wrinkle in its skin, the facial film that allows it use the compositions of the embodiment of the present invention 5 to make, every day sooner or later respectively once, by the German CK skin elasticity tester MPA580 of company test skin elasticity, use the depth of the wrinkle of the skin microscope test skin of extra large optical instrument factory, measure skin brightness with Delfin skin Lightening degree tester SkinGlossMeter and change.
As a result, the 5th day that uses from experimenter starts, and 18 experimenters' skin can detect brightness increase in various degree, melanin decline; Since the 12nd day, it was that elasticity strengthens in various degree that whole 19 experimenters' skin can detect, and wrinkle shoals.The 25th day, the brightness of whole 20 experimenters' skin increased obviously, bright shining coloured silk; The 30th day, whole 20 experimenters' skin elasticity obviously strengthened, and wrinkle detail shoals.
Claims (9)
1. a whitening skin and preserving moisture skin care compositions, is characterized in that, its component is by weight: salvia miltiorrhiza flower a kind of sedge 30-50 part, Pericarpium Citri Reticulatae 20-30 part, Fructus Momordicae 15-25 part, fresh Fructus Mori 10-18 part, Fructus Lycii 5-10 part.
2. whitening skin and preserving moisture skin care compositions according to claim 1, is characterized in that, its component is by weight: salvia miltiorrhiza flower a kind of sedge 35-45 part, Pericarpium Citri Reticulatae 25-28 part, Fructus Momordicae 18-20 part, fresh Fructus Mori 12-15 part, Fructus Lycii 6-8 part.
3. whitening skin and preserving moisture skin care compositions according to claim 1, is characterized in that, its component is by weight: 36 parts of salvia miltiorrhiza flower a kind of sedges, 26 parts of Pericarpium Citri Reticulataes, 19 parts of Fructus Momordicaes, 14 parts of fresh Fructus Mori, 7 parts of Fructus Lyciis.
4. whitening skin and preserving moisture skin care compositions according to claim 3, is characterized in that: described fresh Fructus Mori are purpureal ripe mulberry.
5. the application of the whitening skin and preserving moisture skin care compositions described in claim 1 to 4 any one, is characterized in that, described compositions is made to facial film.
6. the application of the whitening skin and preserving moisture skin care compositions described in claim 1 to 4 any one, is characterized in that, described compositions is made to oral drugs.
7. the preparation method of the whitening skin and preserving moisture skin care compositions described in claim 1 to 4 any one, is characterized in that: comprises the following steps,
(1) choose and weighing raw materials: choose from fructufy and start to start at the Fructus Mori of 20-50 days, and soak after 0.5-1 in the saline solution that is 5-10% at mass fraction, drain to surface moisture naked eyes invisiblely, obtain fresh Fructus Mori raw material; Collect the salvia miltiorrhiza flower a kind of sedge after extracing, after cleaning with clear water, dry to surface moisture naked eyes invisiblely, obtain salvia miltiorrhiza flower a kind of sedge raw material, then choose Pericarpium Citri Reticulatae, Fructus Momordicae and Fructus Lycii, weigh according to described ratio;
(2) comminuted starting materials: the alleged raw material obtaining in step (1) is pulverized together;
(3) extract: the raw material after pulverizing in step (2) is joined in the ethanol that volume fraction is 50-70% and soaked, and add the acetic acid of raw material and total ethanol quality 1-5%, and be aided with ultrasonicly simultaneously, and be heated to 45-50 ℃ and extract, this process amounts to 2-3h, obtains extracting solution;
(4) filtration drying: the extracting solution of gained in step (3) is filtered, get liquid part, carry out lyophilization, to obtain final product.
8. application according to claim 5, is characterized in that: the preparation method of described facial film is, on the basis of the compositions that adopts method claimed in claim 7 to make, adds the pharmaceutically acceptable adjuvant of preparing facial film, to obtain final product.
9. application according to claim 6, is characterized in that: the preparation method of described oral drugs is, on the basis of the compositions that adopts method claimed in claim 7 to make, adds the pharmaceutically acceptable adjuvant of preparing peroral dosage form, to obtain final product.
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| CN201510746155.4A CN105232776A (en) | 2014-04-09 | 2014-04-09 | Oral preparation for whitening, moisturizing and skin caring |
| CN201410139278.7A CN103860439B (en) | 2014-04-09 | 2014-04-09 | A kind of whitening skin and preserving moisture skin care compositions and preparation method thereof |
| CN201510745801.5A CN105326686B (en) | 2014-04-09 | 2014-04-09 | A kind of skin whitening, moisturizing facial treatment mask |
| CN201510745954.XA CN105232399B (en) | 2014-04-09 | 2014-04-09 | A kind of preparation method of skin whitening, moisturizing skin care compositions |
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| CN201510746155.4A Division CN105232776A (en) | 2014-04-09 | 2014-04-09 | Oral preparation for whitening, moisturizing and skin caring |
| CN201510745954.XA Division CN105232399B (en) | 2014-04-09 | 2014-04-09 | A kind of preparation method of skin whitening, moisturizing skin care compositions |
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| CN105326686B (en) | 2018-02-09 |
| CN105232776A (en) | 2016-01-13 |
| CN103860439B (en) | 2016-06-29 |
| CN105326686A (en) | 2016-02-17 |
| CN105232399B (en) | 2017-12-08 |
| CN105232399A (en) | 2016-01-13 |
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Effective date of registration: 20160511 Address after: 200444 Shanghai city Baoshan District Fengxiang Road No. 2000 Applicant after: Shanghai Life-Beauty Cosmetics Co., Ltd. Address before: 610066 Sichuan city of Chengdu province Jinjiang District Temple Road No. 22 Building 1, unit 5, No. 505 Applicant before: Zhao Yue |
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