CN105232776A - Oral preparation for whitening, moisturizing and skin caring - Google Patents
Oral preparation for whitening, moisturizing and skin caring Download PDFInfo
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- CN105232776A CN105232776A CN201510746155.4A CN201510746155A CN105232776A CN 105232776 A CN105232776 A CN 105232776A CN 201510746155 A CN201510746155 A CN 201510746155A CN 105232776 A CN105232776 A CN 105232776A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention discloses an oral preparation for whitening, moisturizing and skin caring, and belongs to the field of cosmetics. Effective components of the oral preparation comprise, by weight, 30-50 parts of Salvia miltiorrhiza flower stalks, 20-30 parts of dried orange peel, 15-25 parts of Corsvenor Momordica Fruit, 10-18 parts of fresh mulberry fruit, and 5-10 parts of wolfberry fruit. The oral preparation adopts five raw materials as composition components, so the oral preparation has the advantages of simple composition, easy obtaining of the materials, and low cost, and whitening and skin caring synergistic effects can be achieved through a proper preparation method; and a mask disclosed in the invention has substantial whitening, spot removing, wrinkle removing, moisturizing, skin tightening and skin caring effects; and a large amount of waste Salvia miltiorrhiza flower stalks and fresh mulberry fruits are effectively utilized, so resource wastes are prevented, the cost is low, and large economic and social benefits are generated.
Description
the application is Chinese patent: application number 2014101392787; Denomination of invention: a kind of whitening skin and preserving moisture skin care compositions and preparation method thereof; The divisional application of the applying date: 2014.04.09.
Technical field
The present invention relates to beauty and skin care technical field, particularly relate to a kind of oral formulations for whitening skin and preserving moisture skin protection.
Background technology
Along with improving constantly of expanding economy and living standard, people have had more and more higher requirement to beauty and skin care; On the other hand, along with the increase of life and work pressure and environmental pollution, skin especially skin of face also worse and worse, skin is pitch-dark, xerosis cutis, the phenomenon such as intense darkness without light annoying increasing people, especially modern female.
At present, the product of various whitening and skin-protecting is had.The product of a lot of chemical composition, due to reasons such as its zest, side effect and DeGrains, is applied less.And Chinese herbal medicine is because its composition is natural, and integration of edible and medicinal herbs, no matter as oral administration or external, there is very large advantage as whitening and skin-protecting.A lot of Chinese medicine has the advantage of integration of edible and medicinal herbs, is widely used in slow down aging and skin whitening etc.Such as, Fructus Lycii (
lyciumbarbarumL.) in a lot of polyphenoils of containing, as the rutin etc. of vitamin E, vitamin C, carotene, betanin, flavonoid, they all can suppress the generation of lipid peroxide well, have very strong anti-oxidation function, can play the effect of speckle skin care, slow down aging.
At present, also have a lot of report Chinese herbal medicine being used for whitening and skin-protecting, if publication number is the Chinese patent application of 101797208A, and for example publication number is the Chinese patent application of 101744756A.These current reports, often have the shortcoming of constituent complexity, the constituent being the Chinese patent application of 101744756A as publication number reaches 20 kinds more than, and other existing compositionss are also more than at least seven kinds.Specifically, first, the complicated component of Chinese medicine, much important composition is understood not yet completely, and too much Chinese medicine mixing, complex reaction can occur each other, add the uncertain risk of Chinese medicine, especially for the medicine used for slow down aging and skin whitening or health product, often need long-term taking, thus add the carcinogenic risk of the even pathogenic teratogenesis of side reaction; Secondly, of a great variety, the collection for production cost, raw material also brings difficulty, especially owes abundant manufacturer for natural resources of Chinese medicinal materials, increases its production cost, directly affects Business Economic Benefit.
In addition, the present report about whitening and skin-protecting, often function singleness, can not simultaneously whitening, moisturizing etc.; And usage limitation, only can be used for external or only can be used for taking orally, effect is also not obvious.
Summary of the invention
Goal of the invention of the present invention, is for above-mentioned Problems existing, provides a kind of constituent simple, with low cost and has the oral formulations of whitening, moistening effect concurrently.
The technical solution used in the present invention is such: a kind of oral formulations for whitening skin and preserving moisture skin protection, the component of the effective ingredient of described oral formulations, be by weight: salvia miltiorrhiza flower a kind of sedge 30-50 part, Pericarpium Citri Reticulatae 20-30 part, Fructus Momordicae 15-25 part, fresh Fructus Mori 10-18 part, Fructus Lycii 5-10 part, also comprise the pharmaceutically acceptable adjuvant preparing oral formulations.
Present inventor is through great many of experiments, adopt salvia miltiorrhiza flower a kind of sedge, Pericarpium Citri Reticulatae, Fructus Momordicae, fresh Fructus Mori and Fructus Lycii as raw material, form new compositions, and determine its suitable proportion, and demonstrate its effect such as whitening, moisturizing, prove that the successfuls such as its whitening, moisturizing, speckle dispelling are better than the effect of at least one adopted in fresh Fructus Mori, Fructus Momordicae, Fructus Lycii simultaneously, be namely provided with whitening, moisturizing, anti-ageing synergistic function of waiting for a long time owing to have employed following preparation method between compositions of the present invention.
In above-mentioned composition of the present invention, labiate Radix Salviae Miltiorrhizae (Salviamiltiorrhiza) is its dry root medicinal mainly, is mainly used in the treatment of cardiovascular disease.In the planting process of Radix Salviae Miltiorrhizae, in order to promote its root growth, the colored a kind of sedge to Radix Salviae Miltiorrhizae is extracted out is needed to extract in time.Often discarded after excision, especially in Radix Salviae Miltiorrhizae GAP planting base, often discarded a large amount of salvia miltiorrhiza flower a kind of sedges, from Chinese medicine point of theory, the salvia miltiorrhiza flower a kind of sedge in above-mentioned composition is as monarch drug.
Pericarpium Citri Reticulatae in above-mentioned composition is the dry mature skin of rutaceae orange (CitrusreticulataBlanco) and variety thereof, it has regulating qi-flowing for strengthening spleen, in tune, dampness, the effect of reducing phlegm, often be used as medicine, yet there are no for skin care industry, be especially used for skin protection as exterior-applied article such as facial film.And the present invention adopts it to coordinate with fresh Fructus Mori etc., as ministerial drug.
Fructus Momordicae (Siraitiagrosvenori) in above-mentioned composition is cucurbitaceous plant, and its effect having lung moistening, eliminate the phlegm, quench one's thirst, also has the effect of loosening bowel to relieve constipation.In addition, Fructus Mori (FructusMori) mature fruit that is Moraceae deciduous tree mulberry.The rural area that mulberry is being bred silkworms is planted in a large number, and annual 5-8 month Fructus Mori are ripe, then lands abandonment after a large amount of often Fructus Mori maturation in rural area.Because of its there is nourishing YIN and supplementing blood, the effect of moisturizing of promoting the production of body fluid, also have as health food or be used as medicine.In beauty treatment, it has the effect of hair color, but has no as the report of skin protection, and in the present compositions, selecting fresh Fructus Mori as raw material, may be because fresh Fructus Mori compare the composition drying or adopt the Fructus Mori of other mode dryings to have whitening and skin-protecting preferably.And in the present compositions, Fructus Momordicae and Fructus Mori are all as adjuvant drug.
In the present compositions, Fructus Lycii (LyciumbarbarumL.) is mainly used in hepatic and renal YIN deficiency, replenishing vital essence to improve eyesight, also report Fructus Lycii is had to may be used for whitening anti-aging, and in the present compositions, adopt Fructus Lycii as making medicine, other several components auxiliary are used for whitening, wrinkle removal, moisturizing and the skin etc. that compacts.
As preferred technical scheme, its component is by weight: salvia miltiorrhiza flower a kind of sedge 35-45 part, Pericarpium Citri Reticulatae 25-28 part, Fructus Momordicae 18-20 part, fresh Fructus Mori 12-15 part, Fructus Lycii 6-8 part.
As further preferred technical scheme, its component is by weight: salvia miltiorrhiza flower a kind of sedge 36 parts, Pericarpium Citri Reticulatae 26 parts, Fructus Momordicae 19 parts, fresh Fructus Mori 14 parts, Fructus Lycii 7 parts.
As preferred technical scheme: described fresh Fructus Mori are purpureal ripe mulberry.Such Fructus Mori are preferably for whitening and skin-protecting.
The preparation method of the effective ingredient of the above-mentioned oral formulations for whitening skin and preserving moisture skin protection, the technical scheme of employing is: comprise the following steps,
(1) to choose and weighing raw materials: choose the Fructus Mori of to start at from fructufy 20-50 days, and be, after soaking 0.5-1 in the saline solution of 5-10%, drain to surface moisture naked eyes invisible, obtain fresh Fructus Mori raw material at mass fraction; Choose new salvia miltiorrhiza flower a kind of sedge extractd, dry to surface moisture naked eyes invisible after cleaning with clear water, obtain salvia miltiorrhiza flower a kind of sedge raw material, then choose Pericarpium Citri Reticulatae, Fructus Momordicae and Fructus Lycii, weigh according to described ratio;
(2) comminuted starting materials: the raw material obtained alleged in step (1) is pulverized together;
(3) extract: it is soak in the ethanol of 50-70% that the raw material after pulverizing in step (2) is joined volume fraction, and add the acetic acid of raw material and total ethanol quality 1-5%, be aided with ultrasonic simultaneously, and be heated to 45-50 DEG C and extract, this process amounts to 2-3h, obtains extracting solution;
(4) filtration drying: the extracting solution of gained in step (3) is filtered, gets liquid part, carry out lyophilization, to obtain final product.
As preferred technical scheme: the preparation method of described facial film is, on the basis of the compositions made at said method, add the pharmaceutically acceptable adjuvant preparing facial film, to obtain final product.
As preferred technical scheme: the preparation method of described oral drugs is, on the basis of the compositions made at said method, add the pharmaceutically acceptable adjuvant preparing peroral dosage form, to obtain final product.
In sum, owing to have employed technique scheme, the invention has the beneficial effects as follows:
First, have employed five kinds of raw materials as constituent, composition is relatively simple, and material is easy to obtain, with low cost, and by suitable preparation method, achieves whitening and skin-protecting cooperative synergism effect;
Then, compositions of the present invention has the skin care effect of significant whitening, speckle dispelling, wrinkle removal, moisturizing, the skin that compacts simultaneously;
In addition, a large amount of discarded salvia miltiorrhiza flower a kind of sedge, fresh Fructus Mori are effectively utilized, prevents the wasting of resources, with low cost, create larger economic benefit and social benefit;
Finally, preparation method of composition of the present invention is simple, is convenient to suitability for industrialized production, is easy to apply.
Detailed description of the invention
The present invention is described in detail below.
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with embodiment, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
Embodiment 1:
A kind of whitening skin and preserving moisture skin care compositions, its component is by weight: salvia miltiorrhiza flower a kind of sedge 30 parts, Pericarpium Citri Reticulatae 20 parts, Fructus Momordicae 15 parts, fresh Fructus Mori 10 parts, Fructus Lycii 5 parts;
Its preparation method is, comprises the following steps,
(1) to choose and weighing raw materials: choose the Fructus Mori of to start at from fructufy 45 days, and be, after soaking 0.8h in the saline solution of 10%, drain to surface moisture naked eyes invisible, obtain fresh Fructus Mori raw material at mass fraction; Collect the salvia miltiorrhiza flower a kind of sedge after extracing, dry to surface moisture naked eyes invisible after cleaning with clear water, obtain salvia miltiorrhiza flower a kind of sedge raw material, then choose Pericarpium Citri Reticulatae, Fructus Momordicae and Fructus Lycii, weigh according to described ratio;
(2) comminuted starting materials: the raw material obtained alleged in step (1) is pulverized together;
(3) extract: it is soak in the ethanol of 60% that the raw material after pulverizing in step (2) is joined volume fraction, and adds the acetic acid of raw material and total ethanol quality 3%, is aided with ultrasonic simultaneously, and be heated to 50 DEG C and extract, this process amounts to 2.5h, obtains extracting solution;
(4) filtration drying: the extracting solution of gained in step (3) is filtered, gets liquid part, carry out lyophilization, to obtain final product.
In addition, the present embodiment, also by the compositions after above-mentioned lyophilization, adds adjuvant and makes tablet or facial film.
Wherein, when making facial film, the adjuvant added is propylene glycol, arabic gum and ethyl hydroxybenzoate.
Using method: when making facial film, the compositions after the above-mentioned lyophilization of every sheet facial film load 2g, every day respectively uses a slice sooner or later, and each applying is no less than 20 minutes.
Make tablet, every sheet is containing the compositions 0.5g after above-mentioned lyophilization, taken three times a day, each serving with 2.
According to the situation of skin, can external simultaneously and for oral administration or only external or for oral administration.
Embodiment 2:
A kind of whitening skin and preserving moisture skin care compositions, its component is by weight: salvia miltiorrhiza flower a kind of sedge 50 parts, Pericarpium Citri Reticulatae 30 parts, Fructus Momordicae 25 parts, fresh Fructus Mori 18 parts, Fructus Lycii 10 parts.
Preparation method is identical with embodiment 1.
Embodiment 3:
A kind of whitening skin and preserving moisture skin care compositions, its component is by weight: salvia miltiorrhiza flower a kind of sedge 35 parts, Pericarpium Citri Reticulatae 25 parts, Fructus Momordicae 18 parts, fresh Fructus Mori 12 parts, Fructus Lycii 6 parts.
Preparation method is identical with embodiment 1.
Embodiment 4:
A kind of whitening skin and preserving moisture skin care compositions, its component is by weight: salvia miltiorrhiza flower a kind of sedge 45 parts, Pericarpium Citri Reticulatae 28 parts, Fructus Momordicae 20 parts, fresh Fructus Mori 15 parts, Fructus Lycii 8 parts.
Preparation method is identical with embodiment 1.
Embodiment 5:
A kind of whitening skin and preserving moisture skin care compositions, its component is by weight: salvia miltiorrhiza flower a kind of sedge 36 parts, Pericarpium Citri Reticulatae 26 parts, Fructus Momordicae 19 parts, fresh Fructus Mori 14 parts, Fructus Lycii 7 parts.
Preparation method is identical with embodiment 1.
Wherein, when making facial film, the adjuvant added is propylene glycol, arabic gum and ethyl hydroxybenzoate.
Using method: when making facial film, the compositions after the above-mentioned lyophilization of every sheet facial film load 2g, every day respectively uses a slice sooner or later, and each applying is no less than 20 minutes.
Make tablet, every sheet is containing the compositions 0.5g after above-mentioned lyophilization, taken three times a day, each serving with 2.
Embodiment 6
The experiment of restraint of tyrosinase activity
Skin darkening and the skin problem such as freckle, brown patch are all due to dye.Main cause due to dye is melanin, and restraint of tyrosinase activity is one of the cardinal principle of whitening, speckle dispelling.This experiment has the effects such as significant whitening, speckle dispelling by the compositions of the experimental verification the application measuring restraint of tyrosinase activity on the one hand.
1, instrument and reagent
FA1604 electronic analytical balance (the auspicious instrument in Shanghai side)
UVB500 ultraviolet-uisible spectrophotometer (Shanghai unit analyzer device)
Tryrosinase, arbutin are purchased from Jiang Lai bio tech ltd, Shanghai.
2, sample
The compositions of employing obtained by the embodiment of the present invention 3 is as test specimen.
3, method of testing
Get four test tubes and put on No. 1, No. 2, No. 3, No. 4 respectively; With reference to reagent dosage and the concentration of table 1, the respective reaction liquid listed by each row is in vitro added respectively at four, jolting is mixed evenly, in 37oC preheating 10min, then respectively in vitro tyrosinase solution is being added respectively, in 37oC accurate response 5min, be transferred to rapidly in cuvette, survey absorbance (A) in 475nm place;
4, result calculates and statistics
Be calculated as follows the suppression ratio to tryrosinase:
Suppression ratio=[1-(A3-A4)/(A1-A2)] × 100%
In formula: A1, A2, A3, A4 represent the absorbance recorded in 475nm place after reaction in No. 1, No. 2, No. 3, No. 4 four test tubes in table 1 respectively.
Table 1: the composition (unit: ml) of liquid to be measured
With the effect causing the inhibitor concentration (IC50) of tryrosinase vigor decline 50% to characterize inhibitor.Restraint of tyrosinase Activity determination the results are shown in Table 2.
Table 2: each sample restraint of tyrosinase Activity determination result
Above result shows that the compositions of the embodiment of the present invention 3 has stronger tyrosinase activity rejection ability, and its activity is better than arbutin.
Meanwhile, contrast experiment has been carried out
The laboratory sample that this contrast experiment adopts is as follows: (ratio is mass ratio), the quality of each sample of employing is equal
Salvia miltiorrhiza flower a kind of sedge 36 parts, Pericarpium Citri Reticulatae 26 parts, Fructus Momordicae 19 parts, fresh Fructus Mori 14 parts, Fructus Lycii 7 parts
No. 1: salvia miltiorrhiza flower a kind of sedge; No. 2: Pericarpium Citri Reticulatae; No. 3: Fructus Momordicae; No. 4: fresh Fructus Mori; No. 5: Fructus Lycii; No. 6: Fructus Lycii+Fructus Momordicae (1:1); No. 7: fresh Fructus Mori+Fructus Lycii (1:1); No. 8: fresh Fructus Mori+Fructus Lycii+Fructus Momordicae (1:1:1); No. 9: the compositions of embodiment 1; No. 10: the compositions of embodiment 2; No. 11: the compositions of embodiment 4; No. 12: the compositions of embodiment 5;
Adopt said method to test, experimental result is as table 3:
Table 3: each sample restraint of tyrosinase Activity determination result (unit: mg/ml)
Embodiment 7
The removing of DPPH free radical is tested
1. instrument and reagent
FA1604 electronic analytical balance (the auspicious instrument in Shanghai side)
UVB500 ultraviolet-uisible spectrophotometer (Shanghai unit analyzer device)
Free radical (DPPH), arbutin are purchased from Jiang Lai bio tech ltd, Shanghai, and ethanol is purchased from Kingsoft, Chengdu reagent company limited.
2. sample
The compositions of employing obtained by the embodiment of the present invention 3 is as test specimen;
3. non-oxidizability experiment
3.1 samples are tested the removing of DPPH free radical
The preparation of DPPH solution:
Accurately take DPPH7.88mg, be placed in 100ml volumetric flask, with anhydrous alcohol solution to scale, obtain the DPPH solution that concentration is 2 × 10-4mo1/l, keep in Dark Place (0 ~ 4 DEG C);
The preparation of test liquid:
Get the extracting solution 40ml of compositions of the present invention, be placed in 200ml volumetric flask, with ethanol dilution to scale;
Assay method:
Extracting sample solution 5ml and 2 × 10-4mo1/lDPPH solution 5ml Homogeneous phase mixing, place 30min in the dark respectively, is that blank measures its absorbance A at 525nm place, and calculates its clearance rate with following formula with methanol:
Clearance rate (%)=and 1-(Ai-Aj)/Ac ］ × 100%
In formula: Ac:5ml ethanol adds the absorbance of 5mlDPPH solution;
Ai:5ml liquid to be measured adds the absorbance of 5mlDPPH solution;
Aj:5ml liquid to be measured adds the absorbance of 5ml ethanol;
According to formulae discovery clearance rate above.
Effect of free radical scavenger is characterized with the activity concentration (IC50) removing DPPH free radical 50%.Radical scavenging activities testing result is in table 4.
Table 4: each sample radical scavenging activities testing result
Result shows that compositions extracting solution of the present invention has stronger DPPH radical scavenging activity, and its activity is better than arbutin.
The laboratory sample that this contrast experiment adopts is as follows: (ratio is mass ratio), the quality of each sample of employing is equal
Salvia miltiorrhiza flower a kind of sedge 36 parts, Pericarpium Citri Reticulatae 26 parts, Fructus Momordicae 19 parts, fresh Fructus Mori 14 parts, Fructus Lycii 7 parts
No. 1: salvia miltiorrhiza flower a kind of sedge; No. 2: Pericarpium Citri Reticulatae; No. 3: Fructus Momordicae; No. 4: fresh Fructus Mori; No. 5: Fructus Lycii; No. 6: Fructus Lycii+Fructus Momordicae (1:1); No. 7: fresh Fructus Mori+Fructus Lycii (1:1); No. 8: fresh Fructus Mori+Fructus Lycii+Fructus Momordicae (1:1:1); No. 9: the compositions of embodiment 1; No. 10: the compositions of embodiment 2; No. 11: the compositions of embodiment 4; No. 12: the compositions of embodiment 5;
Adopt said method to test, experimental result is as table 5:
Table 5: each sample suppresses tyrosine activity testing result (unit: μ g/ml)
Above-mentioned experiment proves that compositions of the present invention achieves whitening, the freckle effect of unexpected excellence.
Embodiment 8
Whitening moisturizing clinical experiment
1, experimental subject:
Choose experimenter 160, women, the age 18-30 year between, and living habit be stay up late for a long time, long-time in the face of computer, the skin of face that skin exists in various degree is dry, dull pitch-dark, is divided into four groups at random, often organizes 40 people,
2, laboratory sample and experimental technique
First group of employing " namely beautiful " whitening and moisturizing facial film, every day is sooner or later respectively once; Second group of facial film adopting the compositions of the embodiment of the present invention 1 to make, every day is sooner or later respectively once; The 3rd group of facial film adopting the compositions of the embodiment of the present invention 5 to make, every day is sooner or later respectively once; The facial film that 4th group of first day only adopts the compositions of embodiment 5 to make, sooner or later respectively once, the tablet that the compositions taking embodiment 5 in second day is made, morning, noon and afternoon every day are each once, so replace;
Experimental period: 30 days
3, detecting instrument:
Skinanalysis apparatus (Korea S EHANG, EH-990U), for moisture change and the melanin situation of change of detection of skin
4, experimental result standard:
Effective: moisture value is between 40-50%, and melanin value is lower than 20
Effective: moisture value is between 20-30%, and melanin value is 20-30
Invalid: moisture value is lower than 20%, and melanin value is more than 30
5, experimental result: as shown in table 6
Table 6 whitening moisturizing clinical trial results (numerical value unit: people)
As can be seen from Table 6, the whitening skin and preserving moisture Be very effective of compositions of the present invention, and adopt external application and mode for oral administration, effect is more excellent.
Embodiment 9
Skin elasticity, the colour of skin, wrinkle clinical experiment
Choose the women of 20 ages in 35-45 year, there is the symptom such as poor flexibility, colour of skin dimness, wrinkle in various degree in its skin, the facial film allowing it use the compositions of the embodiment of the present invention 5 to make, every day sooner or later respectively once, skin elasticity is tested with German CK company skin elasticity tester MPA580, by the depth of the wrinkle of the skin microscope test skin of Shang Hai optical instrument factory, measure skin brightness change with Delfin skin brightness tester SkinGlossMeter.
As a result, what use from experimenter starts on the 5th day, and the skin of 18 experimenters can detect brightness increase in various degree, melanin decline; From the 12nd day, the skin of whole 19 experimenters can detect it is that elasticity strengthens in various degree, and wrinkle shoals.25th day, the brightness of the skin of whole 20 experimenters increased obviously, bright shining coloured silk; 30th day, the skin elasticity of whole 20 experimenters obviously strengthened, and wrinkle detail shoals.
Claims (5)
1. the oral formulations for whitening skin and preserving moisture skin protection, it is characterized in that, the component of the effective ingredient of described oral formulations, be by weight: salvia miltiorrhiza flower a kind of sedge 30-50 part, Pericarpium Citri Reticulatae 20-30 part, Fructus Momordicae 15-25 part, fresh Fructus Mori 10-18 part, Fructus Lycii 5-10 part, also comprise the pharmaceutically acceptable adjuvant preparing oral formulations.
2. oral formulations according to claim 1, is characterized in that, the component of its effective ingredient is by weight: salvia miltiorrhiza flower a kind of sedge 35-45 part, Pericarpium Citri Reticulatae 25-28 part, Fructus Momordicae 18-20 part, fresh Fructus Mori 12-15 part, Fructus Lycii 6-8 part.
3. oral formulations according to claim 1, is characterized in that, its component is by weight: salvia miltiorrhiza flower a kind of sedge 36 parts, Pericarpium Citri Reticulatae 26 parts, Fructus Momordicae 19 parts, fresh Fructus Mori 14 parts, Fructus Lycii 7 parts.
4. oral formulations according to claim 1, is characterized in that, described fresh Fructus Mori are purpureal ripe mulberry.
5. oral formulations according to claim 1, is characterized in that, described oral formulations is tablet.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410139278.7A CN103860439B (en) | 2014-04-09 | 2014-04-09 | A kind of whitening skin and preserving moisture skin care compositions and preparation method thereof |
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| CN201410139278.7A Division CN103860439B (en) | 2014-04-09 | 2014-04-09 | A kind of whitening skin and preserving moisture skin care compositions and preparation method thereof |
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| CN105232776A true CN105232776A (en) | 2016-01-13 |
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| CN201410139278.7A Active CN103860439B (en) | 2014-04-09 | 2014-04-09 | A kind of whitening skin and preserving moisture skin care compositions and preparation method thereof |
| CN201510746155.4A Pending CN105232776A (en) | 2014-04-09 | 2014-04-09 | Oral preparation for whitening, moisturizing and skin caring |
| CN201510745954.XA Active CN105232399B (en) | 2014-04-09 | 2014-04-09 | A kind of preparation method of skin whitening, moisturizing skin care compositions |
| CN201510745801.5A Active CN105326686B (en) | 2014-04-09 | 2014-04-09 | A kind of skin whitening, moisturizing facial treatment mask |
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| CN201510745954.XA Active CN105232399B (en) | 2014-04-09 | 2014-04-09 | A kind of preparation method of skin whitening, moisturizing skin care compositions |
| CN201510745801.5A Active CN105326686B (en) | 2014-04-09 | 2014-04-09 | A kind of skin whitening, moisturizing facial treatment mask |
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| CN107616502A (en) * | 2017-09-20 | 2018-01-23 | 北京军秀咨询有限公司 | A kind of cosmetic slimming nutrition and health care capsule |
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| CN106174578A (en) * | 2015-08-21 | 2016-12-07 | 赵月 | Blood fat reducing beauty-care capsule |
| CN105380843A (en) * | 2015-11-18 | 2016-03-09 | 中山市艾丽意素生物科技有限公司 | Natural plant hydrating lotion and preparation method thereof |
| CN107951778B (en) * | 2017-12-22 | 2021-06-04 | 福建中医药大学 | Shower gel composition and preparation method thereof |
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| CN103263536A (en) * | 2013-02-04 | 2013-08-28 | 四川逢春制药有限公司 | Skin-whitening freckle-removing anti-aging composite and preparation method and application thereof |
| CN103316150A (en) * | 2013-06-21 | 2013-09-25 | 四川逢春制药有限公司 | Composition for preventing aging and whitening skin as well as preparation method and application thereof |
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| JP4754671B2 (en) * | 1999-11-30 | 2011-08-24 | 花王株式会社 | Cosmetics |
| JPWO2004007511A1 (en) * | 2002-07-15 | 2005-11-10 | 株式会社ホソダＳｈｃ | Mangosteen extract |
| JP2008106025A (en) * | 2006-10-23 | 2008-05-08 | Up Great:Kk | Cosmetic |
| CN103027860A (en) * | 2011-09-29 | 2013-04-10 | 庞来祥 | Wolfberry nourishing sleeping mask and preparation method thereof |
| CN102366478B (en) * | 2011-11-14 | 2013-04-03 | 四川逢春制药有限公司 | Composition for whitening skin and resisting senescence, preparation method and application thereof |
| CN102793642B (en) * | 2012-08-28 | 2014-01-15 | 广州丹奇日用化工厂有限公司 | Skin care product composition |
| CN102846520A (en) * | 2012-08-31 | 2013-01-02 | 青岛康泰鑫环保科技有限公司 | Oil-controlling facial cleanser |
| CN103599424B (en) * | 2013-10-21 | 2015-09-02 | 张霞 | A kind of Chinese medicine composition for skin whitening |
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| CN103263536A (en) * | 2013-02-04 | 2013-08-28 | 四川逢春制药有限公司 | Skin-whitening freckle-removing anti-aging composite and preparation method and application thereof |
| CN103316150A (en) * | 2013-06-21 | 2013-09-25 | 四川逢春制药有限公司 | Composition for preventing aging and whitening skin as well as preparation method and application thereof |
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| CN107616502A (en) * | 2017-09-20 | 2018-01-23 | 北京军秀咨询有限公司 | A kind of cosmetic slimming nutrition and health care capsule |
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| Publication number | Publication date |
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| CN105232399A (en) | 2016-01-13 |
| CN105326686B (en) | 2018-02-09 |
| CN105326686A (en) | 2016-02-17 |
| CN103860439A (en) | 2014-06-18 |
| CN103860439B (en) | 2016-06-29 |
| CN105232399B (en) | 2017-12-08 |
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Application publication date: 20160113 |