CN109350578A - Beautifying liquid and preparation method thereof and tyrosinase inhibitor - Google Patents
Beautifying liquid and preparation method thereof and tyrosinase inhibitor Download PDFInfo
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- CN109350578A CN109350578A CN201811604675.1A CN201811604675A CN109350578A CN 109350578 A CN109350578 A CN 109350578A CN 201811604675 A CN201811604675 A CN 201811604675A CN 109350578 A CN109350578 A CN 109350578A
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9722—Chlorophycota or Chlorophyta [green algae], e.g. Chlorella
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- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The present invention provides a kind of beautifying liquid and preparation method thereof and tyrosinase inhibitor.The beautifying liquid includes tyrosinase inhibitor, and in terms of the gross mass of the beautifying liquid, the additional amount of the tyrosinase inhibitor is 0.01-6%；The tyrosinase inhibitor includes ginseng extract and dendrobium candidum extract.The formula of beautifying liquid of the invention is mild, can effectively inhibit the activity of tyrosinase, to play the role of whitening.Tyrosinase enzyme inhibitor of the invention is excellent to the inhibiting effect of tyrosinase activity and without side-effects to human body.
Description
Technical field
The present invention relates to a kind of beautifying liquid and preparation method thereof and tyrosinase inhibitors, belong to cosmetic field.
Background technique
" skin whitening " is the eternal topic and pursuit of the vast women that likes to be beautiful.Research and development, safety and the function of Skin whitening care cosmetics
Effect property evaluation nature becomes researcher, operator and consumer's focus of attention.The color of skin is mainly by skin pigment
Content and publication determine that melanin is most important determinant.Melanocyte in skin generates melanin, melanin
Grain is shifted by the dendritic protrusion of melanocyte to horn cell, is transferred to the melanin granule of horn cell on epidermal cell
Row is to cuticula, so that cutaneous color or formation color spot, finally fall off with cuticula and drained.
In addition, ultraviolet irradiation can also enable melanin generate variation, a kind of substance for protecting skin is generated, then black
Element moving layer by layer via cell metabolism again, has arrived skin epidermis, forms color spot that we are seen and the colour of skin is irregular etc.
Skin problem.
Inhibit tyrosinase activity or block tyrosinase generation black currently, general skin-whitening agents mainly pass through
The route of synthesis of pigment, so that the production for reducing melanin has the function that whitening.Such skin-whitening agents mainly have arbutin,
Quinhydrones and derivative, L-AA and derivative, kojic acid and its derivative, Vitamin C Ethyl Ether and its derivative, nicotinoyl
Amine, Trenaxmine, benzenediol and its derivative etc..But but, if largely mixing these substances, sometimes in use feeling and
It is led to the problem of in safety.As irritation of the quinhydrones to skin is very big；Kojic acid is easy to change and also has certain stimulation to skin
Property；Arbutin acts on single and ineffective etc..
As people increase skin health attention rate, develop with safety and stability, effect is obvious and cost performance is high
Natural whitening agent, it has also become one of the main direction of studying of current medicine and cosmetic industry has extraordinary development prospect.
Summary of the invention
Problems to be solved by the invention
In view of in the prior art, quinhydrones is very big to the irritation of skin；Kojic acid is easy to change and also has to skin certain
Irritation；The problems such as arbutin effect is single and ineffective, present invention firstly provides a kind of tyrosinase enzyme inhibitors.This hair
Bright tyrosinase enzyme inhibitor is excellent to the inhibiting effect of tyrosinase activity and without side-effects to human body.
Further, the present invention also provides a kind of beautifying liquids, and formula is mild, can effectively inhibit the work of tyrosinase
Property, to play the role of whitening.
Further, the present invention also provides a kind of easy to operate, preparation methods for the beautifying liquid that raw material is easily obtained.
The solution to the problem
The present invention provides a kind of beautifying liquid comprising tyrosinase inhibitor, it is described in terms of the gross mass of the beautifying liquid
The additional amount of tyrosinase inhibitor is 0.01-6%；The tyrosinase inhibitor includes that ginseng extract and dendrobium candidum mention
Take object.
Beautifying liquid according to the present invention, wherein the beautifying liquid further includes moisturizer, emulsifier, chelating agent, pH adjusting
Agent, skin conditioning agent and Shu Min agent；Wherein, in terms of the gross mass of the beautifying liquid, the additional amount of the moisturizer is 0.01-
20%, the additional amount of the emulsifier is 0.01-0.5%；The additional amount of pH adjusting agent is 0.01-1%；The skin conditioning agent
Additional amount be 0.01-5%；The additional amount of the Shu Min agent is 0-5%；The additional amount of the chelating agent is 0.01-1%.
Beautifying liquid according to the present invention, wherein the moisturizer include propylene glycol, butanediol, 1,2- pentanediol, panthenol,
One of dipropylene glycol, glycerol, glycerol polymethacrylates, glycerine polyacrylate, Sodium Hyaluronate, trehalose or two
Kind or more combination.
Beautifying liquid according to the present invention, wherein the emulsifier includes glycerol alcohol ether -25PCA isostearate, PEG-10
Campesterol, isosteareth -20, sorbitan sesquioleate, laureth -7, -3 methyl two of polyglycereol are hard
The group of one or more of resin acid ester, PEG/PPG-10/1 dimethyl silicone polymer, polyglyceryl-3 diisostearate
It closes.
Beautifying liquid according to the present invention, wherein the chelating agent includes tetra- sodium of EDETATE SODIUM and/or EDTA；And/or
The pH adjusting agent includes citric acid, sodium lactate, sodium citrate, sodium hydroxide, potassium hydroxide, triethanolamine, ammonia
The combination of one or more of methylpropanol, arginine.
Beautifying liquid according to the present invention, wherein the skin conditioning agent includes that allantoin, sea lettuce extract, phaeodactylum tricornutum refer to
Algae extract, bulk kelp extract, chlorella tunning, Hydrolyzed Collagen, brown alga extract, Herba Visci leaf extract
The combination of one or more of object, cogongrass rhizome extractive, Radix et Caulis Opuntiae Dillenii extract；And/or
The Shu Min agent includes bisabolol, ginger-root extract, aloe vera extract, Gotu Kola P.E, dent
The combination of one or more of amaranth extract, evening primrose oil, leaf of Herba Andrographitis extract, hamamelis water.
Beautifying liquid according to the present invention, wherein in the U.S. solution, in terms of the gross mass of the tyrosinase inhibitor,
The additional amount of the ginseng extract is 0.3-80%, and the additional amount of the dendrobium candidum extract is 20-99.7%；
Preferably, the mass ratio of the ginseng extract and the dendrobium candidum extract is 1:0.1~100, preferably
1:0.5~90, more preferably 1:1~75, further preferably 1:2~60 are still more preferably 1:3~55, further
Preferably 1:3.5~50.
The present invention also provides a kind of tyrosinase inhibitors comprising: ginseng extract and dendrobium candidum extract,
In, in terms of the gross mass of the tyrosinase inhibitor, the additional amount of the ginseng extract is 0.3-80%, the iron sheet stone
The additional amount of dry measure used in former times extract is 20-99.7%.
Tyrosinase inhibitor according to the present invention, wherein the ginseng extract and the dendrobium candidum extract
Mass ratio is 1:0.1~100, preferably 1:0.5~90, more preferably 1:1~75, further preferably 1:2~60, more into one
Step is preferably 1:3~55, much further preferably from 1:3.5~50.
The present invention also provides a kind of preparation methods of beautifying liquid according to the present invention comprising: by each of the beautifying liquid
The step of component mixes.
The effect of invention
Tyrosinase enzyme inhibitor of the invention is excellent to the inhibiting effect of tyrosinase activity and without side-effects to human body.
Further, the formula of beautifying liquid of the invention is mild, can effectively inhibit the activity of tyrosinase, to play
The effect of whitening.
Further, the preparation method of beautifying liquid of the invention is easy to operate, and raw material is easily obtained, and can give birth in batches
It produces.
Detailed description of the invention
Fig. 1 shows logarithm mass concentration-tyrosinase inhibition rate pass of the ginseng extract of comparative example 1-5 of the present invention
System's figure；
Fig. 2 shows logarithm mass concentration-tyrosinase inhibition rates of the dendrobium candidum extract of comparative example 6-9 of the present invention
Relational graph；
Fig. 3 shows logarithm mass concentration-tyrosinase inhibition rate of the tyrosinase inhibitor of 1-7 of the embodiment of the present invention
Relational graph.
Fig. 4 shows the content and interaction of ginseng extract in the tyrosinase inhibitor of 1-7 of the embodiment of the present invention
The relational graph of coefficient.
Fig. 5 shows the comparison diagram of the melanin change rate of Application Example 1-8 of the present invention and Comparison study example 1-2.
Specific embodiment
It will be detailed below various exemplary embodiments, feature and aspect of the invention.Dedicated word " example herein
Property " mean " being used as example, embodiment or illustrative ".Here as any embodiment illustrated by " exemplary " should not necessarily be construed as
Preferred or advantageous over other embodiments.
In addition, in order to better illustrate the present invention, numerous details is given in specific embodiment below.
It will be appreciated by those skilled in the art that without certain details, the present invention equally be can be implemented.In other example,
Method well known to those skilled in the art, means, equipment and step are not described in detail, in order to highlight master of the invention
Purport.
First embodiment
First embodiment of the invention provides a kind of tyrosinase inhibitor, comprising: ginseng extract and dendrobium candidum
Extract.Tyrosinase inhibitor of the invention can be good at inhibiting the activity of tyrosinase, in cosmetics in use, special
It is not in beautifying liquid in use, having excellent whitening effect.
Ginseng (Panax ginseng C.A.Meyer) is Araliaceae (Araliaceae) herbaceos perennial, ginseng
It is one of the resources of medicinal plant of Changbai Mountain most potentiality to be exploited.
Chemical component there are many containing in ginseng, such as: ginsenoside, panaxan, ginseng protein and polypeptide etc..Wherein,
Ginsenoside (Ginsenoside) is a kind of steroid compound, is with dammarane type, with Fourth Ring in chemical structure
Triterpene is the triterpenoid saponin of primary structure.Ginsenoside is one of the representative active constituent in ginseng, is widely present in ginseng
In platymiscium.Panaxan is other a kind of effective active composition of ginseng, is good natural effective component.Panaxan
With small-molecule chemical therapeutic agent use in conjunction, destruction of the chemotherapeutic agent to human immune system can be repaired and reduce,
Play the effect of Synergy and attenuation.
Ginseng extract can be used as a kind of natural additive for Cosmetic Manufacture.Ginsenoside has anti-oxidant, anti-purple
The effects of outside line, protection skin, be one of the physiological activator in ginseng.Ginsenoside can also stimulate skin fibroblasts
Activity, promote collagen synthesis, so that skin is tended to rejuvenation, so that the process of delay skin aging, plays its anti-aging
Effect, and increase SOD content and activity in skin simultaneously in a certain range.Content of ginsenoside is higher in ginseng extract
When, DPPH (1,1- diphenyl -2- trinitrophenyl-hydrazine) free radical can be removed.
Dendrobium candidum (Dendrobium officinale) is the perennial herbaceous plant that grows nonparasitically upon another plant of orchid family Dendrobium.Iron sheet stone
The emplastic of the stem of dry measure used in former times is mainly water-soluble polysaccharide, and the water-soluble polysaccharide of dendrobium candidum is a kind of immunopotentiator.
Dendrobium candidum extract original of the invention is from the stem of dendrobium candidum.In general, dendrobium candidum not only can be with
It moisturizes the skin, enhance skin elasticity, reducing wrinkle of skin and prevent skin aging.Dendrobium candidum extract can also help to eliminate tired
Labor, stress of releiving, regains one's strength of body, brain tonic salubrity.In addition dendrobium candidum extract can also boost metabolism and enhance machine
Energy effect has moistening lung, gut purge heat, effect of tonifying lung void.
The present invention uses the combination of ginseng extract and dendrobium candidum extract, and the two has synergistic effect, can be into one
Step plays the role of inhibiting tyrosinase activity.In the present invention, in terms of the gross mass of the tyrosinase inhibitor, the people
The additional amount of conopsea extraction is 0.3-80%, and the additional amount of the dendrobium candidum extract is 20-99.7%.
In the present invention, it is preferred to the mass ratio of the ginseng extract and the dendrobium candidum extract be 1:0.1~
100, preferably 1:0.5~90, more preferably 1:1~75, further preferably 1:2~60, still more preferably for 1:3~
55, much further preferably from 1:3.5~50.When the mass ratio of ginseng extract and dendrobium candidum extract within the above range
When, can further have synergistic effect, the excellent effect inhibited tyrosinase activity.
Second embodiment
Second embodiment of the present invention provides a kind of beautifying liquid, the tyrosinase comprising first embodiment of the invention
Inhibitor, in terms of the gross mass of the beautifying liquid, the additional amount of the tyrosinase inhibitor is 0.01-6%, preferably 0.1-
5%；Such as the additional amount of tyrosinase inhibitor may is that 0.5%, 1%, 2%, 3%, 4%, 4.5% etc..The present invention passes through
Tyrosinase inhibitor of the invention is added, the activity of tyrosinase is able to suppress, to play excellent whitening effect.Work as junket
When the additional amount of propylhomoserin enzyme inhibitor is between 0.01-6%, reduced using melanin content in the skin after beautifying liquid.This hair
The bright tyrosinase inhibitor of the invention by addition, is able to suppress the activity of tyrosinase, to play excellent whitening effect
Fruit.
In addition to tyrosinase inhibitor, beautifying liquid of the invention further includes moisturizer, emulsifier, chelating agent, pH adjusting
Agent, skin conditioning agent and Shu Min agent.The formula composition of beautifying liquid of the invention is mild, and tyrosinase of the invention can be made to inhibit
The effect of agent, is not fully exerted.Specifically:
In terms of the gross mass of the beautifying liquid, the additional amount of the moisturizer is 0.01-20%.When the additional amount of moisturizer
In 0.01-20%, moisture-keeping function can be played.The effect of in order to enable moisturizer, further plays, moisturizing of the invention
3% the additional amount of agent can be 1-18%, can be 3-16%, can be 5-14%, can be 6-12%, such as: 2%,
6%, 8%, 10%, 12%, 15%, 17%, 19% etc..
In the present invention, the moisturizer include propylene glycol, butanediol, 1,2- pentanediol, panthenol, dipropylene glycol, glycerol,
The combination of one or more of glycerol polymethacrylates, glycerine polyacrylate, Sodium Hyaluronate, trehalose.
In terms of the gross mass of the beautifying liquid, the additional amount of the emulsifier is 0.01-0.5%.Such as: it can be
0.05-0.4% can be 0.1-0.3% etc..When the emulsifier of the application is less than 0.01%, cause to emulsify insufficient make
The system of obtaining is unstable；When emulsifier is greater than 0.5%, certain influence will cause to the stability of product.
The emulsifier includes glycerol alcohol ether -25PCA isostearate, PEG-10 campesterol, isosteareth -
20, sorbitan sesquioleate, laureth -7, polyglycereol-3-methyl distearate, PEG/PPG-10/1 poly- two
The combination of one or more of methylsiloxane, polyglyceryl-3 diisostearate.
The present invention uses glycerol alcohol ether -25PCA isostearate as emulsifier, can moisturize the skin, can be in skin
Surface forms oiliness protective film, reduces the injury of outer bound pair skin, keeps whitening skin water tender.
In terms of the gross mass of the beautifying liquid, the additional amount of the skin conditioning agent is 0.01-5%.Specifically, described
The additional amount of skin conditioning agent can be 0.1-4%, can be 0.3-3%, can be 0.5-2% etc..When skin conditioning agent
When additional amount is less than 0.01%, corresponding effect can not be played.
The skin conditioning agent includes allantoin, sea lettuce extract, Phaeodactylum tricornutum extract, bulk kelp extract, bead
Algae tunning, Hydrolyzed Collagen, brown alga extract, Herba Visci leaf extract, cogongrass rhizome extractive, cactus are extracted
The combination of one or more of object.
Wherein, sea lettuce extract is the active constituent that extracts in the thallus of Ulvaceae plant sea lettuce or U. pertusa.Sea lettuce
Contain a variety of unsaturated fatty acids, aldehyde (such as citral) ingredient in extract.Sea lettuce extract have sterilization, moistening skin-care it
Effect.
Wherein, allantoin can reduce the adhesion strength of corneocyte, accelerate epidermal cell to update, enhance the reparation of skin
Ability, and its degree of safety is high.
Wherein, bulk kelp is the mass propagation by macroalgal cells, and bulk kelp extract is the activity extracted from bulk kelp
Ingredient, the natural plant protein with high-content.Bulk kelp extract has effects that supplement cytotrophy, the work of effective moisturizing
With.
In terms of the gross mass of the beautifying liquid, the additional amount of the Shu Min agent is 0-5%.Specifically, the Shu Min agent
Additional amount can be 0.1-4%, can be 0.5-3%, can be 0.6-2% etc..It can according to need, be properly added Shu Min
Agent.
The Shu Min agent includes bisabolol, ginger-root extract, aloe vera extract, Gotu Kola P.E, dent
The combination of one or more of amaranth extract, evening primrose oil, leaf of Herba Andrographitis extract, hamamelis water.
Wherein, hamamelis water has excellent anti-inflammatory, and anti-anaphylaxis is releived and convergent effect, while holding there are also good
Outlet capacity.
In terms of the gross mass of the beautifying liquid, the additional amount of pH adjusting agent is 0.01-1%.By adding pH adjusting agent, make
The pH value of beautifying liquid human skin preferably.Preferably, the additional amount of pH adjusting agent of the invention can be 0.03-0.8%,
It can be 0.05-0.5%, can be 0.06-0.3% etc..When the additional amount of pH adjusting agent is greater than 1% or less than 0.01%
When, it cannot obtain the suitable beautifying liquid of pH value.In the present invention, the pH adjusting agent includes citric acid, sodium lactate, citric acid
The combination of one or more of sodium, sodium hydroxide, potassium hydroxide, triethanolamine, aminomethyl propanol, arginine.
Beautifying liquid of the invention can also be properly added antioxidant and chelating agent.In general, with the beautifying liquid
Gross mass meter, the additional amount of the antioxidant is 0-2%；The additional amount of the chelating agent is 0.01-1%.The antioxygen
Agent can be one of vitamin E, tocopherol acetate, Butylated Hydroxytoluene, lycopene, ascorbic acid ethylether etc. or two
Kind or more combination.The chelating agent can be tetra- sodium of EDETATE SODIUM and/or EDTA etc..
In addition, also including preservative and aromatic in beautifying liquid of the invention.In terms of the gross mass of the beautifying liquid, institute
The additional amount for stating preservative is 0.01-1.5%；The additional amount of the aromatic is 0.01-1%.The preservative may include
The combination of one or more of Phenoxyethanol, methyl hydroxybenzoate, Nipasol, benzyl alcohol, benzoic acid and its salt.The virtue
Pastil can be essence etc..
U.S. solution of the invention can not only play the role of whitening, and it has effects that certain importing, be easy quilt
Percutaneous absorption, the effect that enhancing skin absorbs skin care item promote the absorption for promoting skin to subsequent maintenance.It is more in its formula
Kind ingredient can bring skin nutrition abundant, keep skin delicacy soft and smooth.
Third embodiment
Third embodiment of the present invention provides a kind of preparation method of the beautifying liquid of second embodiment, including by institute
The step of stating each component mixing of cosmetics.
Specifically, by taking beautifying liquid as an example, the preparation method of the beautifying liquid the following steps are included:
1, stirring is added in Jiang Shui, moisturizer, chelating agent, part preservative, pH adjusting agent, partial skin conditioner raw material
Pot, is stirred and heated to 75-85 DEG C；
2, it is cooled to 40-50 DEG C, emulsifier is added, aromatic, tyrosinase inhibitor, remaining skin conditioning agent, remains
Remaining preservative, Shu Min agent, the antioxidant being optionally present stir evenly；
3, it is cooled to 30-40 DEG C, is discharged after the assay was approved, stands 12-48 hours；
4, it after the assay was approved, dispenses, pack, then examine, warehousing finished products.
Embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and should not be taken as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is
It can be with conventional products that are commercially available.
Comparative example 1-5
Take ginseng extract as tyrosinase inhibitor.It is 6.8 by the pH that ginseng extract is dissolved in 5 groups of different volumes
In phosphate buffer, the test solution of 5 groups of various concentrations is obtained.Wherein, the logarithm mass concentration of ginseng extract such as the following table 2 institute
Show.
Comparative example 6-9
Take dendrobium candidum extract as tyrosinase inhibitor.Dendrobium candidum extract is dissolved in 4 groups and comparative example 1-4
In the phosphate buffer that the pH of corresponding volume is 6.8, the test solution of 4 groups with comparative example 1-4 corresponding concentration is obtained.Wherein, iron
The logarithm mass concentration of skin Herba Dendrobii extract is as shown in table 2 below.
Embodiment 1-7
Take ginseng extract and dendrobium candidum extract as tyrosinase inhibitor.By ginseng extract and dendrobium candidum
Extract 2:1 in mass ratio (embodiment 1), 1:1 (embodiment 2), 1:2 (embodiment 3), 15:85 (embodiment 4), 5:95 (are implemented
Example 5), 2:98 (embodiment 6), 7:68 (embodiment 7) mixing after, obtain tyrosinase inhibitor.By embodiment 1-5,7 junket ammonia
Sour enzyme inhibitor is dissolved in respectively in the phosphate buffer that the pH of 5 groups and comparative example 1-5 corresponding volume is 6.8, by the junket of embodiment 6
Propylhomoserin enzyme inhibitor is dissolved in the pH of 4 groups and comparative example 1-4 corresponding volume respectively in 6.8 phosphate buffer.Embodiment 1-7 is equal
The test solution of 5 groups available (or 4 groups) and comparative example 1-5 (or comparative example 1-4) corresponding concentration.Wherein, tyrosinase presses down
In preparation, the content (quality %) of ginseng extract and dendrobium candidum extract as shown in table 1 below, pair of tyrosinase inhibitor
Number mass concentration is as shown in table 3 below.
Table 1
Testing in vitro
Tyrosinase activity is measured with being catalyzed the tyrosinase vigor of L-3,4 dihydroxyphenylalanine generation DOPA quinone.Specifically:
1 test tube is taken, is added substrate L-3,4 dihydroxyphenylalanine solution 0.4mL (1.0mg/mL), and adds the phosphate buffer that pH is 6.8
After 2.4mL, 30 DEG C of water-bath heat preservation 10min, the amount that tyrosinase is then added is 0.2mL (250U/mL), obtains reaction solution 1.
1 test tube is taken, the amount that tyrosinase is added is 0.2mL (250U/mL), and adds the phosphate buffer that pH is 6.8
2.8mL obtains reaction solution 2.
Substrate L-3,4 dihydroxyphenylalanine solution 0.4mL (1.0mg/mL) is added in 43 test tubes respectively, is then respectively adding 2.4mL's
The test solution of comparative example 1-9 and embodiment 1-7, after 30 DEG C of water-baths keep the temperature 10min, the amount that tyrosinase is then added is
0.2mL (250U/mL), obtains reaction solution 3.
The test solution of the comparative example 1-9 and embodiment 1-7 of 2.4mL is added in 43 test tubes respectively, and adds pH and is
After 6.8 phosphate buffer 0.4mL, 30 DEG C of water-bath heat preservation 10min, the amount that tyrosinase is then added is 0.2mL (250U/
ML), reaction solution 4 is obtained.
L-3,4 dihydroxyphenylalanine is converted red product DOPA quinone by enzymatic reaction, there is absorption maximum at 475nm.Reading is opened from mixing
Absorbance A when beginning 1min at 475nm475, the speed of enzymatic reaction A per minute475Value added indicate.It measures above-mentioned
Absorbance A of the reaction solution when reaction starts 1min at 475nm, and the inhibition to tyrosinase activity is calculated as follows
Rate.Wherein, the mass concentration of the tyrosinase inhibitor in table is whole quality of the tyrosinase inhibitor in test system
Concentration.
Inhibiting rate=[1- (A3-A4)/(A1-A2)] × 100%
In formula: A1Not add tyrosinase inhibitor, only containing substrate when absorbance；
A2Absorbance not add tyrosinase inhibitor, and when not adding substrate；
A3To contain tyrosinase inhibitor and absorbance when substrate；
A4Absorbance to contain tyrosinase inhibitor, and when not adding substrate.
It calculates separately to obtain ginseng extract (comparative example 1-5) and dendrobium candidum extract (comparative example 6-9) is respective right
The inhibiting rate of tyrosinase activity.And logarithm mass concentration-tyrosinase inhibition rate relational graph is combined, conversion acquires ginseng and mentions
Corresponding mass concentration (the IC when inhibiting rate of object being taken to be 50%50A) with the inhibiting rate of dendrobium candidum extract be 50% when it is corresponding
Mass concentration (IC50B), the results are shown in Table 2.
Table 2
Then the inhibiting rate of the tyrosinase of the tyrosinase inhibitor of embodiment 1-7 is measured.And combine logarithm quality dense
Degree-tyrosinase inhibition rate relational graph, conversion acquires ginseng extract and the generation of dendrobium candidum extract compound action is equivalent
When inhibiting rate (50%), the mass concentration (IC of ginseng extract50a), ginseng extract and dendrobium candidum extract compound action
When generating equivalent inhibiting rate (50%), the mass concentration ((IC of dendrobium candidum extract50b), the results are shown in Table 3.
The effect of the compound action of ginseng extract and dendrobium candidum extract can be commented with interaction coefficient γ
Valence, concrete outcome are as shown in table 3.
γ=IC50a/IC50A+IC50b/IC50B
Wherein, IC50AThe inhibiting rate for indicating ginseng extract corresponding mass concentration when being 50%；
IC50BThe inhibiting rate for indicating dendrobium candidum extract corresponding mass concentration when being 50%；
IC50aWhen indicating that ginseng extract and dendrobium candidum extract compound action generate equivalent inhibiting rate (50%), ginseng
The mass concentration of extract；
IC50bWhen indicating that ginseng extract and dendrobium candidum extract compound action generate equivalent inhibiting rate (50%), iron sheet
The mass concentration of Herba Dendrobii extract.
Wherein, γ=1 indicates that ginseng extract and dendrobium candidum extract show as simple additive effect；γ < 1 is people
Conopsea extraction and dendrobium candidum extract show as synergistic effect, and γ value is smaller, and synergistic effect is stronger；γ > 1 is ginseng extraction
Object and dendrobium candidum extract show as antagonistic effect, and γ value is bigger, and antagonistic effect is bigger.
Table 3
As can be seen from Table 3, the interaction coefficient in tyrosinase inhibitor of the invention is less than 1, and its phase interaction
It can be below 0.6 with coefficient value, it might even be possible to 0.5 hereinafter, therefore ginseng extract and dendrobium candidum extract can be with tables
It is now excellent synergistic effect.
Application Example 1-8
According to the content (mass percent) of each component in the beauty formula of liquid of the Application Example 1-8 in the following table 4-5, and
Beautifying liquid is prepared according to following production craft steps.Production craft step is as follows:
1, agitated kettle is added in A, B phase raw material, is stirred and heated to 82-85 DEG C；
2,42 DEG C are cooled to, C, D phase is added and stirs evenly；
3,37 DEG C are cooled to, is discharged after the assay was approved, stands 24 hours；
4, it after the assay was approved, dispenses, pack, then examine, warehousing finished products.
Note: A, B, C, D, E, F phase in technique is respectively,
A phase: water；
B phase: butanediol, 1,2- pentanediol, dipropylene glycol, Sodium Hyaluronate, allantoin, glycerol, panthenol, citric acid, sea
Algae sugar, sodium citrate, EDETATE SODIUM, glycerol polymethacrylates, methyl hydroxybenzoate；
C phase: glycerol alcohol ether -25PCA isostearate, essence；
D phase: ginseng extract, dendrobium candidum extract, sea lettuce extract, bulk kelp extract, hamamelis water, benzene first
Alcohol.
Wherein, butanediol, 1,2- pentanediol, dipropylene glycol, Sodium Hyaluronate, glycerol, panthenol, trehalose, the poly- first of glycerol
Base acrylate is moisturizer；
Citric acid, sodium citrate are pH adjusting agent；EDETATE SODIUM is chelating agent；
Glycerol alcohol ether -25PCA isostearate is emulsifier；Hamamelis water is Shu Min agent；
Ginseng extract, dendrobium candidum extract are tyrosinase inhibitor；
Sea lettuce extract, bulk kelp extract, allantoin are skin conditioning agent；
Methyl hydroxybenzoate, benzyl alcohol are preservative；Essence is aromatic.
In the present invention, ginseng extract, manufacturer: Zhan Hong Biotechnology Co., Ltd of Quzhou City；
Dendrobium candidum extract, manufacturer: Zhan Hong Biotechnology Co., Ltd of Quzhou City.
Table 4
Comparison study example 1-2
According to the content (mass percent) of each component in the beauty formula of liquid of the Comparison study example 1-2 in the following table 5, and press
According to method identical with Application Example 1-8, beautifying liquid is prepared.
Table 5
White-skinned face function test
The test method of dermal melanin change rate: by measure specific wavelength illumination on human skin after reflection
Measure the content to determine melanin in skin.It is respectively tri- kinds of 568nm, 660nm and 880nm that the transmitter of probe, which issues wavelength,
The light of wavelength is radiated at skin surface, and recipient measures the light of skin reflex, and measures the amount for the light being absorbed by the skin, so as to
To obtain the change rate of dermal melanin.
The test of dermal melanin change rate is tested using the detector for pigment of CK company of Germany, wherein skin is black
The test probe MX 18 of pigment is made of light source emitter and receiver, to the pressure of skin when having spring separately to keep detection
It is constant.The measurement range of probe is 0-999, and measurement numerical value is higher, it may be said that the content of melanin is higher in bright skin.
Number of subjects is 33 people, and the test period is 4 weeks, and beautifying liquid and the application of Application Example 1-8 is chosen in test
The beautifying liquid of comparative example 1-2 is applied to the different zones of inner forearm sooner or later daily, (Day1) and use before measurement experiment respectively
Volume reflection of the skin in the tested region of (Day28) after the illumination of specific wavelength is at 28 days to determine containing for melanin in skin
Amount, and then the change rate of melanin is characterized, the result of the change rate of specific melanin is as shown in Figure 5.
As seen from Figure 5, the change rate of the melanin of the Application Example 1-8 of the application is larger, i.e. melanin content
It reduces, therefore, uses ginseng extract and dendrobium candidum extract as tyrosinase inhibitor, it being capable of whitening effect skin.
In addition, in the Application Example 6-8 of the application, since the content of ginseng extract is higher, melanin content drop
It is low less.
In the Comparison study example 1-2 of the application, extracted in single use ginseng extract or single use dendrobium candidum
When object is as tyrosinase inhibitor, melanin content change rate is small, and melanin content reduces less, and whitening effect is poor.
The above embodiment of the present invention be only to clearly illustrate example of the present invention, and not be to the present invention
Embodiment restriction.For those of ordinary skill in the art, it can also make on the basis of the above description
Other various forms of variations or variation.There is no necessity and possibility to exhaust all the enbodiments.It is all of the invention
Made any modifications, equivalent replacements, and improvements etc., should be included in the protection of the claims in the present invention within spirit and principle
Within the scope of.
Claims (10)
1. a kind of beautifying liquid, which is characterized in that including tyrosinase inhibitor, in terms of the gross mass of the beautifying liquid, the junket
The additional amount of propylhomoserin enzyme inhibitor is 0.01-6%；The tyrosinase inhibitor includes that ginseng extract and dendrobium candidum extract
Object.
2. beautifying liquid according to claim 1, which is characterized in that the beautifying liquid further includes moisturizer, emulsifier, chelating
Agent, pH adjusting agent, skin conditioning agent and Shu Min agent；Wherein, in terms of the gross mass of the beautifying liquid, the additional amount of the moisturizer
For 0.01-20%, the additional amount of the emulsifier is 0.01-0.5%；The additional amount of pH adjusting agent is 0.01-1%；The skin
The additional amount of skin conditioner is 0.01-5%；The additional amount of the Shu Min agent is 0-5%；The additional amount of the chelating agent is
0.01-1%.
3. beautifying liquid according to claim 2, which is characterized in that the moisturizer includes propylene glycol, butanediol, 1,2- penta
Glycol, panthenol, dipropylene glycol, glycerol, glycerol polymethacrylates, glycerine polyacrylate, Sodium Hyaluronate, in trehalose
A combination of one or more.
4. beautifying liquid according to claim 2 or 3, which is characterized in that the emulsifier includes glycerol alcohol ether -25PCA different
Stearate, PEG-10 campesterol, isosteareth -20, sorbitan sesquioleate, laureth -7, gather it is sweet
Oily -3 methyl distearates, PEG/PPG-10/1 dimethyl silicone polymer, one in polyglyceryl-3 diisostearate
Kind or two or more combinations.
5. according to the described in any item beautifying liquids of claim 2-4, which is characterized in that the chelating agent include EDETATE SODIUM and/
Or tetra- sodium of EDTA；And/or
The pH adjusting agent includes citric acid, sodium lactate, sodium citrate, sodium hydroxide, potassium hydroxide, triethanolamine, aminomethyl
The combination of one or more of propyl alcohol, arginine.
6. according to the described in any item beautifying liquids of claim 2-5, which is characterized in that the skin conditioning agent include allantoin,
Sea lettuce extract, Phaeodactylum tricornutum extract, bulk kelp extract, chlorella tunning, Hydrolyzed Collagen, brown alga are extracted
The combination of one or more of object, Herba Visci leaf extract, cogongrass rhizome extractive, Radix et Caulis Opuntiae Dillenii extract；And/or
The Shu Min agent includes that bisabolol, ginger-root extract, aloe vera extract, Gotu Kola P.E, purslane mention
Take the combination of one or more of object, evening primrose oil, leaf of Herba Andrographitis extract, hamamelis water.
7. beautifying liquid according to claim 1-6, which is characterized in that in the U.S. solution, with the tyrosine
The gross mass meter of enzyme inhibitor, the additional amount of the ginseng extract are 0.3-80%, the addition of the dendrobium candidum extract
Amount is 20-99.7%；
Preferably, the mass ratio of the ginseng extract and the dendrobium candidum extract is 1:0.1~100, preferably 1:0.5
~90, more preferably 1:1~75, further preferably 1:2~60 are still more preferably 1:3~55, much further preferably from
1:3.5~50.
8. a kind of tyrosinase inhibitor characterized by comprising ginseng extract and dendrobium candidum extract, wherein with institute
The gross mass meter of tyrosinase inhibitor is stated, the additional amount of the ginseng extract is 0.3-80%, and the dendrobium candidum extracts
The additional amount of object is 20-99.7%.
9. tyrosinase inhibitor according to claim 8, which is characterized in that the ginseng extract and the iron sheet stone
The mass ratio of dry measure used in former times extract is 1:0.1~100, preferably 1:0.5~90, more preferably 1:1~75, further preferably 1:2
~60, it is still more preferably 1:3~55, much further preferably from 1:3.5~50.
10. a kind of preparation method of beautifying liquid according to claim 1-7 characterized by comprising will be described
The step of each component mixing of beautifying liquid.
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Effective date of registration: 20220824 Address after: No.23 Xianke Er Road, Huadong Town, Huadu District, Guangzhou City, Guangdong Province 510800 Patentee after: GUANGZHOU KENENG COSMETIC RESEARCH Co.,Ltd. Patentee after: GUANGDONG DANZ GROUP Co.,Ltd. Address before: No.23, Xianke 2nd Road, Huadong Town, Huadu District, Guangzhou City, Guangdong Province, 510890 Patentee before: GUANGZHOU KENENG COSMETIC RESEARCH Co.,Ltd. Patentee before: GUANGZHOU BAIYUN LIANJIA FINE CHEMICAL PLANT Patentee before: GUANGDONG DANZ GROUP Co.,Ltd. |