CN108904708A - A kind of pure Chinese herbal medicine extract and its preparation method and application with moisture-keeping efficacy - Google Patents
A kind of pure Chinese herbal medicine extract and its preparation method and application with moisture-keeping efficacy Download PDFInfo
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- CN108904708A CN108904708A CN201811068271.5A CN201811068271A CN108904708A CN 108904708 A CN108904708 A CN 108904708A CN 201811068271 A CN201811068271 A CN 201811068271A CN 108904708 A CN108904708 A CN 108904708A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9741—Pteridophyta [ferns]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention belongs to the technical field of biological medicine more particularly to a kind of pure Chinese herbal medicine extracts and its preparation method and application with moisture-keeping efficacy.The present invention provides a kind of pure Chinese herbal medicine extracts, are prepared by following raw material is extracted：Dendrobium nobile, ginseng, Radix Astragali, radix polygonati officinalis, Selaginella tamariscina and green plum.The invention also discloses the preparation methods of the pure Chinese herbal medicine extract, include the following steps：The dendrobium nobile, the ginseng, the Radix Astragali, the radix polygonati officinalis, the Selaginella tamariscina and the green plum are milled by step 1, obtain mixture；The mixture is mixed with extracting solution and is extracted and separating treatment by step 2, obtains pure Chinese herbal medicine extract.The present invention can effectively solve that moistening effect existing for existing natural moisturizer is bad, color is deep, stability is poor and the bad technological deficiency of existing skin care item ingredients.
Description
Technical field
The invention belongs to the technical field of biological medicine more particularly to a kind of pure Chinese herbal medicine extracts with moisture-keeping efficacy
And its preparation method and application.
Background technique
Skin is the organ that human body is directly contacted with the external world, is easy to be influenced by extraneous dry air, ultraviolet light, makes skin
Skin is damaged, dry water shortage.Skin water shortage, cytoplasm are reduced, and skin follows the string and reparative regeneration speed slows down, and can go out
The skin problems such as existing shrivelled, wrinkle.And after skin aging, stratum corneum barrier is weak, and such vicious circle leads to barrier reparation
Always it is in a backward condition.Therefore, moisturizing is the basis that cosmetics play other effects.
Moisturizer used in cosmetics can be divided into three categories according to moisturizing mechanism at present：One, sealer, predominantly ester
Class can form one layer of oil film in skin surface, prevent moisture of skin from scattering and disappearing, including dimethyl siloxane, sher butter etc.；
Two, water absorbing agent absorbs moisture in air, prevents moisture from evaporating, including the polyalcohols such as glycerol, propylene glycol, butanediol；Three, it is bionical
Agent, external source performance supplement the ingredient, including ceramide, lactic acid, hyaluronic acid etc. of stratum corneum barrier structure or function.
From the point of view of the development trend of current domestic and international market raw material, using the Chinese herbal medicine extract with moisture-keeping efficacy as function
Energy property ingredient, has been to be concerned by more and more people, and the natural mild moisturizer of development is the demand of significant market.For example, from
The avenabeta glucosan extracted in α-mannosan for extracting in tremella, oat is all bionical dose often added in moisturizing cosmetic
Class moisturizing raw material.The ingredient that it is good that stability is made in the Chinese herbal medicine extract of Saccharideisomerate is added in cosmetics, assigns and producing
The good moisture-keeping efficacy of product is another advantage of moisturizer, and the trend of current cosmetic industry development.
Existing Chinese herbal medicine moisturizing class skin care item still have following aspect problem：One, there are many natural moisturizer on the market, but
It is that action principle is single, so that the moistening effect generated is limited, compounding is needed to can be only achieved outstanding moistening effect.Such as publication number
For 106727164 A of CN patent while being added to dendrobium candidum extract, also added Sodium Hyaluronate and carboxymethyl
Chitosan is to improve its moisture-retaining capacity；Beta glucan is added in 106491428 A of CN.Two, natural moisturizer is universal
In the presence of the problems such as such as color is deep, stability is bad, bad with existing skin care item ingredients.Due to these deficiencies, Chinese medicine is protected
Humectant can only add a little, and dosage is small can not to play its real effect.Such as adding for 106619394 A Chinese herbal medicine extract of CN
Adding as 0.02%~4%, CN, 101961298 A Chinese herbal medicine extract additive amount is 0.05%~2.5%.Three, guarantor on the market
Humectant is mainly macromolecular moisturizing materials, has effect to be but difficult to be absorbed, is easy to produce sticky sense, this is that skin care item should avoid
's.Four, its is ionic relatively strong for the moisture-keeping efficacy object for declaring pure Chinese medicine most of at present, easily leads to product system in application process
Collapse, this is in daily use chemicals industrial application pure Chinese medicine one urgent problem to be solved of moisturizer.
Summary of the invention
In view of this, the main object of the present invention is to provide, a kind of easy Transdermal absorption, effect is comprehensive, stability is good, no
Generate greasy feeling, ionic small pure natural moisturizer.
The present invention provides a kind of pure Chinese herbal medicine extracts, are prepared by following raw material is extracted：Dendrobium nobile, ginseng, Huang
Stilbene, radix polygonati officinalis, Selaginella tamariscina and green plum.
It should be noted that pure Chinese herbal medicine extract is by dendrobium nobile, ginseng, Radix Astragali, radix polygonati officinalis, Selaginella tamariscina and six kinds of green plum natural plants
Object is extracted to be formed, and has the function of that total care skin especially prevents skin water loss.Chinese medicine think skin moisturizing and
Moisturizing and three spleen, lung, kidney internal organs have substantial connection；The spleen being the foundation of acquired constitution, source of generating QI and blood.Spleen and stomach function is normal, qi and blood
Vigorous, human body can just have sufficient moisture, and skin is possible to reach and make moist.Lung plays the role of a surname and send out respectful drop, if lung function mistake
Often, the ability of defeated cloth aqueous is lost, body cannot normally be supported moist.The main water of kidney is that water is dirty, separating clear and excreting turbid,
Clear person returns to lung by the rising gasification of yang-energy in kidney, then by the lung spreading whole body, maintains intracorporal normal water liquid measure.So
Moisturizing moisturizing will support outside internal body, interior tune, work along both lines, and skin water could really be kept to moisten.
Preferably, the mass percent of the raw material is：
Dendrobium nobile 10%~50%；
Ginseng 5%~40%；
Radix Astragali 5%~40%；
Radix polygonati officinalis 5%~40%；
Selaginella tamariscina 1%~30%；
Green plum 1%~30%.
Preferably, the mass percent of the raw material is：
Dendrobium nobile 20%~40%；
Ginseng 10%~20%；
Radix Astragali 10%~20%；
Radix polygonati officinalis 10%~20%；
Selaginella tamariscina 2%~10%；
Green plum 2%~10%.
More preferably, the dendrobium nobile is specially fresh dendrobium candidum, and the mass percent of dendrobium candidum is 25%-30%.
Wherein, dendrobium nobile returns stomach, kidney channel, reinforcing stomach reg fluid, nourishing Yin and clearing heat.Most important functional component first is that dendrobium nobile in dendrobium nobile
Polysaccharide.The stem of dendrobium nobile is the main extract part of dendrobium polysaccharide, in order to extract polysaccharide to greatest extent, needs to do after harvesting
It is extracted before dry, in case polysaccharide is consumed as nutriment.In addition, dendrobium candidum contains the superoxide dismutase of greater activity
Enzyme, peroxidase, catalase etc., and the metal ion generated to catalysis free radical has chelation, has relatively strong
Oxidation resistance.Fresh dendrobium candidum is low compared with other dendrobium nobile water content, and fresh weight polyoses content is up to 15%, is that extraction dendrobium nobile is more
The preferred raw material of sugar.
More preferably, the mass percent of the ginseng is 20%-25%.
Wherein, Ginseny spleen invigorating, lung, the heart channel of Hang-Shaoyin, reinforce the spleen to benefit the lung, promoting production of body fluid and inducing sedation of the mind.Ginseng is described as " King of Herbs ", " enriching yin from ancient times
Mend life, strengthen the body resistance to consolidate the constitution " superfine product.Ginseng contains a variety of saponins and polysaccharide component, and leachate can by skin slow-absorbing and invariably
Good stimulation is adjustable the water and oil balance of skin, prevents skin dehydration, hardening, corrugation；The total glycosides of ginseng can significantly improve skin antioxygen
Change enzyme activity and reinforcing fiber activity, adjust skin metabolism, improve blood circulation, skin can be made full of elasticity, make cell
It is reborn.Rb-1 in ginsenoside has absorption enhancement effect, and moisture-keeping efficacy is enable to go deep into skin.
More preferably, the mass percent of the Radix Astragali is 20%.
Wherein, Radix Astragali return lung, the spleen channel, invigorating qi for consolidating superficies, inducing diuresis for removing edema.Glycine betaine in Radix Astragali is imitated with good moisturizing
Fruit, and the ingredients such as general flavone and Total saponin have significant antioxidant activity, can inhibit the generation of free radical and remove internal mistake
Surplus free radical, and then extend cell survival.
More preferably, the mass percent of the radix polygonati officinalis is 15%.
Wherein, radix polygonati officinalis attaches to the lung and stomach meridians, and nourishing yin to moisten dryness promotes the production of body fluid to quench thirst.Wherein radix polygonati officinalis mucopolysaccharide, radix polygonati officinalis Fructooligosaccharides, which have, lives
Skin, water holding, moisturizing effect.Fragrant solomonseal rhizome polyoses can significantly improve the performance of keeping humidity of pure Chinese herbal medicine extract of the present invention, in low humidity
(40%) under the conditions of, the hydroscopicity of fragrant solomonseal rhizome polyoses is higher than polyethylene glycol 10000, glycerol, and moisturizing efficiency can maintain 16 hours.
More preferably, the mass percent of the Selaginella tamariscina is 10%.
Wherein, Selaginella tamariscina, alias " Herba Selaginellae ", after dry many years, imposing moisture can restore as usual, to have extremely strong
Drought-resistant ability.The reason is that the washiness in Selaginella tamariscina is to combine water to exist.Main active trehalose is of the invention
The moisturizing monomer of pure Chinese herbal medicine extract.The evaporation of moisture on the skin can be effectively reduced in Selaginella tamariscina, and has the effect of skin-active,
Flesh can be enabled to moisten bright.
More preferably, the mass percent of the green plum is 5%.
Wherein, green plum contains more than 10 acid ingredients and vitamin, predominantly citric acid, malic acid, and wherein citric acid contains
Amount is significantly larger than other fruit.Citric acid, which has, to be promoted skin cell metabolism, anti-aging, inhibits melanin production etc. to make
With.Plum extract has good facilitation to the generation of collagen, can allow skin that bright full state is presented；
Additionally has the function of antiallergic antibacterial, suitable for sensitive flesh moisturizing nursing.
Specifically, dendrobium nobile is dendrobium candidum.
The invention also discloses the preparation methods of the pure Chinese herbal medicine extract, include the following steps：
The dendrobium nobile, the ginseng, the Radix Astragali, the radix polygonati officinalis, the Selaginella tamariscina and the green plum are milled by step 1, obtain
To mixture；
The mixture is mixed with extracting solution and is extracted and separating treatment by step 2, obtains pure Chinese herbal medicine extract.
Preferably, being extracted as heating extraction described in step 2, room temperature is extracted or low temperature extracts.
Wherein, the temperature that low temperature extracts is 0-20 DEG C.
Specifically, preparation method of the invention, includes the following steps：By the dendrobium nobile, the ginseng, the Radix Astragali, institute
Radix polygonati officinalis, the Selaginella tamariscina and green plum milling are stated, adds 10~30 times of deionized water soaking and stirrings in medicinal powder after being pulverized
30 minutes or more, be pumped into after mixing in microjet extractor, extracted under the conditions of 0~20 DEG C, obtain extracting solution, by extracting solution into
After row centrifugation, by the multistage UF membrane of obtained centrifugate, pure Chinese herbal medicine extract is obtained.
Preferably, the extracting solution is the aqueous solution of water and lower alcohol or lower alcohol.
Preferably, the partial size of the mixture is 50 mesh.
Preferably, the separating treatment is multistage membrane separation.
Specifically, the membrane aperture of the multistage membrane separation is respectively 1 μm, 0.45 μm and 100nm.
It should be noted that multistage membrane separation has purification, Multistage Membranes separation is based on molecular sieve principle, finally
Orientation obtains the identical molecular substance of size in a certain range, can reach salt moisture by the substance that multistage membrane separation technique separates
From effect, obtain small-molecule substance, be easy to be absorbed by the skin so that pure Chinese herbal medicine extract of the invention easily absorb and without glutinous
Soapy feeling.
The present invention also provides the pure Chinese herbal medicine extracts to prepare the application in skin care item.
Preferably, the skin care item are selected from one of creme, lotion, aqua, gel, facial mask and lotion or more
Kind.
The invention also discloses a kind of skin care item, including the pure Chinese herbal medicine extract.
Preferably, the additive amount of the pure Chinese herbal medicine extract is 0.1%~50% according to mass percentage.
The present invention is chosen suitable medicinal material and plays its benefit with Chinese medicine tradition prescription thinking prescription according to " monarch " principle
Kidney moistening lung and invigorating the spleen maximum effect, and gained knowledge and proved using modern biotechnology.Skin is especially prevented with total care skin
The function of skin water loss, the present invention are to take dendrobium nobile, ginseng, Radix Astragali for main ingredient, kidney tonifying moistening lung and invigorating the spleen, nourishing Yin and promoting production of body fluid；It is aided with jade
Bamboo, nourishing Yin and moistening dryness, blood-enrich moisten and support skin；It is equipped with Selaginella tamariscina and green plum again, active cell vigor promotes cell metabolism,
Oil-water balance and skin health are maintained, keeps the permanent water of skin tender, moist.Raw material contains dendrobium polysaccharide, super oxygen after extracting
The total glycosides of compound mutase, peroxidase, catalase, ginseng, glycine betaine, astragalus flavonid, total saponins in astragalus, radix polygonati officinalis are viscous
The tens of kinds of compounds such as polysaccharide, radix polygonati officinalis Fructooligosaccharides, Selaginella tamariscina trehalose, citric acid, malic acid and vitamin, can play good
Skin care effect.With modern biology angle, the present invention passes through skin using dendrobium nobile and ginseng extract as bionical dose in moisturizer
After skin absorbs, it can be allowed to not volatile in conjunction with the free water in skin, and the Rb-1 in ginsenoside makees with absorption enhancement
With the problem of moisturizer effect floats on surface has been solved perfectly；Radix Astragali, radix polygonati officinalis, spikemoss extract are as the water suction in moisturizer
Agent absorbs the moisture in air, while can also prevent the moisture loss in skin.This compounding is synergistic, moisturizing
Significant effect is better than independent extract.
It has the following advantages compared with the prior art：
One, water absorbing agent and bionical dose are combined, a variety of active ingredients is synergistic.Mucopolysaccharide tool in dendrobium nobile and radix polygonati officinalis
There is good absorption moisture function；The trehalose in glycine betaine, Selaginella tamariscina in Radix Astragali can in conjunction with the hydrogen in hydrone, point
It is intertwined to form reticular structure between son, there is good film forming, prevent moisture loss；Organic acid and vitamin in green plum
Skin nutrition is given, the hydrophilic ability of keratoprotein is improved；Saponin(e in last ginseng has the effect of promoting skin to absorb.This six
Taste medicinal material, complements each other, and maximizes moisture-keeping efficacy.
Two, other than the moisture-keeping efficacy on basis, there are also Herba Dendrobii extracts, the sweet tea of Radix Astragali for pure Chinese herbal medicine extract of the invention
Dish alkali, plum extract, therefore, pure Chinese herbal medicine extract of the invention is also with anti-oxidant, anti-aging function.The present invention
Pure Chinese herbal medicine extract with excellent moisturizing add antioxidation, can just have excellent anti-aging effects.
Three, pure Chinese herbal medicine extract of the invention extracts mainly small-molecule substance, is easy to be absorbed by the skin, therefore
Pure Chinese herbal medicine extract of the invention has salubrious skin sense, easily absorb and without glutinous soapy feeling, and it is ionic small, be suitable for big portion
The wet class daily chemical products of code insurance.
Four, pure Chinese herbal medicine extract of the invention is formed using all natural Chinese herbal medicine is extracted, ionic small, is compared
In synthetics, the present invention have it is safer, the advantages of having no toxic side effect.
Five, the simple process of pure Chinese herbal medicine extract of the invention, preparation process there is no calorifics, chemically, biology
Property variation.It has good stability, multiple types cosmetics can be made an addition to without there is the problems such as Precipitation.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described.
Fig. 1 is the photo that subject does not smear sample in the embodiment of the present invention 12；
Fig. 2 is photo comparison's figure that subject smears 1 hour skin of sample in the embodiment of the present invention 12；
Fig. 3 is photo comparison's figure that subject smears 2 hours skin of sample in the embodiment of the present invention 12；
Fig. 4 is photo comparison's figure that subject smears 4 hours skin of sample in the embodiment of the present invention 12.
Specific embodiment
The present invention provides a kind of pure Chinese herbal medicine extract and its preparation method and application with moisture-keeping efficacy, for solving
Moistening effect existing for certainly existing natural moisturizer is bad, color is deep, stability is poor, bad with existing skin care item ingredients
Technological deficiency.
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation
Example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common
Technical staff's every other embodiment obtained without making creative work belongs to the model that the present invention protects
It encloses.
Wherein, raw material used in following embodiment is commercially available or self-control.
Embodiment 1
The embodiment of the present invention provides the first pure Chinese herbal medicine extract, is made of following mass percent component：Iron sheet stone
Dry measure used in former times 50%, ginseng 20%, Radix Astragali 10%, radix polygonati officinalis 10%, Selaginella tamariscina 5% and green plum 5%.
Specific preparation method includes the following steps：
(1) it pre-processes：Medicinal material is weighed according to the above component, and is ground into 50 mesh powder；Each medicinal material is mixed and is incorporated in water
Soaking and stirring 30 minutes, obtain medicinal material mixed liquor；
(2) it extracts：By in medicinal material mixture pump in a subtle way efflux extracting tank, extract 3 times, every time 2 hours；
(3) it separates：It is centrifuged using horizontal centrifuge, collects clarified solution；Room temperature carries out more driven by pressure
Grade UF membrane, membrane aperture is respectively 1 μm, 0.45 μm and 100nm.It collects filtrate and is refining to obtain the pure medium-height grass of the first active
Medicament extract.
Embodiment 2
The present embodiment provides second of pure Chinese herbal medicine extracts, are made of following mass percent component：Dendrobium candidum
20%, ginseng 10%, Radix Astragali 20%, radix polygonati officinalis 40%, Selaginella tamariscina 5%, green plum 5%.
Specific preparation method includes the following steps：
(1) it pre-processes：Medicinal material is weighed according to the above component, and is ground into 50 mesh powder；Each medicinal material is mixed and is incorporated in water
Soaking and stirring 30 minutes, obtain medicinal material mixed liquor；
(2) it extracts：By in medicinal material mixture pump in a subtle way efflux extracting tank, extract 3 times, every time 2 hours；
(3) it separates：It is centrifuged using horizontal centrifuge, collects clarified solution；Room temperature carries out more driven by pressure
Grade UF membrane, membrane aperture is respectively 1 μm, 0.45 μm and 100nm.It collects filtrate and is refining to obtain the pure medium-height grass of active second
Medicament extract.
Embodiment 3
The present embodiment provides the third pure Chinese herbal medicine extracts, are made of following mass percent component：Dendrobium candidum
10%, ginseng 20%, Radix Astragali 15%, radix polygonati officinalis 20%, Selaginella tamariscina 30% and green plum 5%.
Specific preparation method includes the following steps：
(1) it pre-processes：Medicinal material is weighed according to the above component, and is ground into 50 mesh powder；Each medicinal material is mixed and is incorporated in water
Soaking and stirring 30 minutes, obtain medicinal material mixed liquor；
(2) it extracts：By in medicinal material mixture pump in a subtle way efflux extracting tank, extract 3 times, every time 2 hours；
(3) it separates：It is centrifuged using horizontal centrifuge, collects clarified solution；Room temperature carries out more driven by pressure
Grade UF membrane, membrane aperture is respectively 1 μm, 0.45 μm and 100nm.It collects filtrate and is refining to obtain the third active pure medium-height grass
Medicament extract.
Embodiment 4
The present embodiment provides the 4th kind of pure Chinese herbal medicine extracts, are made of following mass percent component：Dendrobium candidum
30%, ginseng 20%, Radix Astragali 20%, radix polygonati officinalis 15%, Selaginella tamariscina 10% and green plum 5%.
Specific preparation method includes the following steps：
(1) it pre-processes：Medicinal material is weighed according to component, and is ground into 50 mesh powder；Mixed be incorporated in water of each medicinal material is impregnated
Stirring 30 minutes, obtains medicinal material mixed liquor；
(2) it extracts：By in medicinal material mixture pump in a subtle way efflux extracting tank, extract 3 times, every time 2 hours；
(3) it separates：It is centrifuged using horizontal centrifuge, collects clarified solution；Room temperature carries out more driven by pressure
Grade UF membrane, membrane aperture is respectively 1 μm, 0.45 μm and 100nm.It collects filtrate and is refining to obtain the 4th kind of active pure medium-height grass
Medicament extract.
Embodiment 5
The present embodiment provides the 5th kind of pure Chinese herbal medicine extracts, are made of following mass percent component：Dendrobium candidum
25%, ginseng 25%, Radix Astragali 20%, radix polygonati officinalis 15%, Selaginella tamariscina 10%, green plum 5%.Specific preparation method includes the following steps：
(1) it pre-processes：Medicinal material is weighed according to the above component, and fine crushing at 50 mesh powder；Each medicinal material is mixed and is incorporated in 70%
Soaking and stirring 30 minutes in ethyl alcohol, obtain medicinal material mixed liquor；
(2) it extracts：By in medicinal material mixture pump in a subtle way efflux extracting tank, extracts 3 times, 2 hours every time, obtain active extraction
Object；
(3) it is concentrated：Activity extract is concentrated under reduced pressure, the 5th kind of active pure Chinese herbal medicine extract is obtained.
Embodiment 6
The present embodiment provides the first lotions with moisture-keeping efficacy, are calculated by mass percentage, the specific steps are that：
Component A：Methyl glucoside semi-rigid acid esters 2.8%, cetostearyl alcohol 3%, ethylhexyl palmitate 2%, two
Methylsiloxane 1.5%, jojoba oil 2.5%；
B component：Deionized water (surplus to 100%), EDETATE SODIUM 0.05%；
Component C：Phenoxyethanol 0.5%, triethanolamine 0.25%, the 4th kind of pure Chinese herbal medicine extract 5%；
Specific preparation method：A phase, B heat phase are weighed to 80 DEG C~85 DEG C；A is added to B phase, is stirred evenly, homogeneous 3
Minute, it is stirred for 20 minutes；C phase is added after being cooled to 45 DEG C to stir evenly.
Embodiment 7
The present embodiment provides the first facial masks with moisture-keeping efficacy, are calculated by mass percentage, the specific steps are that：
Component A：Deionized water (surplus to 100%), 1.3- butanediol 20%, glycerol 32%, hydroxyethyl cellulose 1.2%
With reed fragrant plant oil 0.8%；
B component：Phenoxyethanol 0.5%, the 5th kind of pure Chinese herbal medicine extract 5%.
Specific preparation method：A phase dispersing and dissolving is weighed, is stirred at room temperature 30 minutes；A phase is warming up to 75 DEG C again and is stirred for 20
Minute；B phase is added after being cooled to 45 DEG C to stir evenly.
Comparative example 1
This comparative example provides the comparative example of the first herbal composite, is made of following mass percent component：Radix polygonati officinalis
40%, Radix Astragali 40%, Selaginella tamariscina 10%, green plum 4%, dendrobium candidum 5% and ginseng 1%.Preparation method is the same as embodiment 1.
Comparative example 2
This comparative example provides the comparative example of second of herbal composite, is made of following mass percent component：Iron sheet
Dendrobium nobile 30%, ginseng 20%, Radix Astragali 20%, radix polygonati officinalis 15%, Selaginella tamariscina 10%, aloe 5%.Preparation method is the same as embodiment 1.
Embodiment 8
The 4th kind of pure Chinese herbal medicine extract moisturizing test of embodiment 4 is present embodiments provided, specific step is as follows：
Principle：Weight method carry out moisturizing test, using drier setting constant-temperature constant-humidity environment (25 ± 2 DEG C of temperature, humidity 28
± 2%), evaluation is under drying condition environment, the ability of the holding moisture of the 4th kind of pure Chinese herbal medicine extract.
Instrument, reagent：Hygrometer, saturation calcium chloride solution.
Weight method moisturizing test one：Under the conditions of 25 DEG C, saturation calcium chloride solution is put into drier bottom, uses hygrometer
Measurement prepares the dry environment that humidity environment is 28%.The crystallising dish that placed a certain amount of sample is put into drier and is carried out
Moisturizing test.The crystallising dish that sample will be placed with every 12 hours takes out weighing, each sample take three it is parallel.Measurement front and back sample
Weight difference calculate moisturizing rate：Weight before moisturizing rate (%)=1- (weight before weight-test when test)/test.
Sample：Experimental group is the 4th kind of pure Chinese herbal medicine extract of 5% mass percent；Control group is 0.5% mass hundred
Divide the Sodium Hyaluronate of ratio；Blank group is water.Experimental result is shown in Table 1.
Moisturizing test result under 1 low-moisture conditions of table
| Initial average output value | 12h average value | Average value for 24 hours | 48h average value | 72h average value | |
| Experimental group | 25.11 | 23.85 | 21.34 | 12.55 | 8.78 |
| Control group | 25.23 | 21.69 | 18.16 | 10.34 | 6.30 |
| Blank group | 25.09 | 21.32 | 14.05 | 8.02 | 4.26 |
The unit of table 1：Gram.
Interpretation of result：Under low-humidity environment, the moisture that experimental group has lost 65% after 72 hours is lower than control group
75%, the 83% of blank group, the 4th kind of pure Chinese herbal medicine extract for illustrating embodiment 4 under low humidity conditions, still have good
Moisture holding capacity.
Embodiment 9
The 5th kind of pure Chinese herbal medicine extract moisturizing test of embodiment 5 is present embodiments provided, specific step is as follows：
Principle：Weight method carry out moisturizing test, using drier setting constant-temperature constant-humidity environment (25 ± 2 DEG C of temperature, humidity 80
± 2%), evaluation is under wet condition environment, the ability of the absorption moisture of the 5th kind of pure Chinese herbal medicine extract.
Instrument, reagent：Hygrometer, saturated ammonium sulfate solution.
Weight method moisturizing test two：Under the conditions of 25 DEG C, saturated ammonium sulfate solution is put into drier bottom, uses hygrometer
Measurement prepares the dry environment that humidity environment is 80%.The crystallising dish that placed a certain amount of sample is put into drier and is carried out
Moisturizing test.The crystallising dish that sample will be placed with every 12 hours takes out weighing, each sample take three it is parallel.Measurement front and back sample
Weight difference calculate inhale moisturizing rate：Weight before hydroscopicity (%)=(weight before weight-test when test)/test.
Sample：Experimental group is the embodiment 5 of 5% mass percent；Control group is the hyaluronic acid of 0.5% mass percent
Sodium；Blank group is water, and experimental result is shown in Table 2
Moisturizing test result under 2 high humidity of table
The unit of table 2：Gram.
Interpretation of result：Under high humidity environment, control group and blank group are all being lost moisture with slow speed, and test
Group, after having spent first 24 hours, the later period starts slowly to moisturize.Illustrate that the 5th kind of pure Chinese herbal medicine of embodiment 5 is extracted
Object has good wettability power.
Embodiment 10
The herbal composite of pure Chinese herbal medicine extract and comparative example 1 and 2 to above-described embodiment 1 to 5 carries out low humidity guarantor
Wet and high humidity moisturizing test, by the herbal composite pure water of the pure Chinese herbal medicine extract of embodiment 1 to 5 and comparative example 1 and 2
After being diluted to 5%, one, two methods are tested by the weight method moisturizing of above-described embodiment 8 and embodiment 9 and carry out 48 hours compliance test results,
The results are shown in Table 3.
3 48 hours weighing moisturizing test results of table
The unit of table 3：Gram.
As can be seen from Table 3, compared to comparative example 1 and comparative example 2, the pure Chinese herbal medicine extract of the embodiment of the present invention 1~5 is equal
With under the conditions of low humidity (28%) water lock moisturizing, absorb water moistening effect under the conditions of high humidity (80%).
Embodiment 11
The present embodiment is the keratoderma hydration rate of testing example 6, and specific step is as follows：
Principle：Moisture content using capacitance method measurement human skin keratinocyte's layer is that the dielectric based on water He other substances is normal
Number significant difference, according to the difference of keratoderma moisture content, the skin pricktest capacitance measured is different, and parameter can represent skin
Moisture content.
Test environment conditions：20 DEG C~22 DEG C, humidity 40%~60%.
Instrument：German Courage+Khazaka skin hydration measuring instrument CM 825.
Subject：25 people.
Subject's condition：Between 18~50 years old age；The basic value of forearm test zone capacitance method moisture of skin analyzer
Between 15~45；Without serious systemic disease；No active anaphylactic disease；Without the high sensitive subjects of constitution.
Reagent and material：Dried noodle paper handkerchief, emgloves, pipettor.
Prepare before test：Subject's both hands inner forearm is carried out measured zone and is marked, Experimental Area at least 3cm × 3cm, often
At least 1cm is spaced between a test zone.It sits quietly in standard compliant room 20 minutes before formal measurement, keeps loosening.
Measurement：(experimental group is the lotion of embodiment 6 to test sample；Matrix group is the lotion with embodiment 6, and difference is
Remove the 4th kind of pure Chinese herbal medicine extract in embodiment 6 in component C；Blank group is pure water) list is carried out by the dosage of 2mg/cm2
Sample is spread evenly across trial zone using emgloves by secondary coating.Each region is measured in parallel at least 3 times.First measure each survey
The initial value for trying region, then measures the moisture content of skin in tested region after setting time.Setting time is one hour, two small
When, three hours.Test result is shown in Table 4.
4 keratoderma hydration rate testing result of table
| Initial average output value | 0h average value | 1h average value | 2h average value | 3h average value | |
| Experimental group | 23.7% | 50.0% | 41.0% | 38.9% | 36.2% |
| Matrix group | 25.0% | 41.2% | 28.6% | 27.0% | 26.1% |
| Blank group | 23.0% | 29.8% | 24.4% | 24.2% | 23.7% |
Interpretation of result：The lotion (containing the 4th kind of pure Chinese herbal medicine extract) of experimental group, that is, embodiment 6 keeps skin water to contain
The ability of amount is substantially better than matrix group and blank group, illustrates that the lotion of embodiment 6 keeps the ability of skin water content to be substantially better than
The matrix group and water of emulsion components are contained only, there is outstanding moisture-keeping efficacy.
Embodiment 12
The present embodiment is the performance that the alleviation of the first pure Chinese herbal medicine extract of testing example 1 has dry skin, peels,
Specific step is as follows：
Sample：Experimental group is the first pure Chinese herbal medicine extract of embodiment 1；Blank group is pure water.
Subject：Totally 10 people 18 years old~45 years old, has dry skin, has slight decortication；No serious systemic disease is lacked without immune
Sunken or autoimmune disease person；No active anaphylactia person；Previously to skin-care cosmetics without severe allergy person；Nearly 1
Hormone medicine and immunosuppressor person are not used in a month.
Test environment：Temperature is 25 DEG C ± 1 DEG C；Humidity is 50% ± 5%.
Test method：It takes pictures and records when not smearing sample, in inner forearm for selecting 5cm × 5cm test area,
Single application is carried out by the dosage of 2mg/cm2, sample is spread evenly across trial zone using emgloves.Test area is divided into a left side
Blank group is smeared on right two parts, the left side (A) of Fig. 1-Fig. 4, and experimental group is smeared on the right (B) of Fig. 1-Fig. 4.It takes pictures simultaneously after 1 hour
Record effect is primary, takes pictures after 2 hours and records second of result, take pictures after 4 hours and record result third time.Test result
Such as attached drawing 1- attached drawing 4, Fig. 1 is skin when not smearing sample, and Fig. 2 is to smear 1 hour skin of sample, and Fig. 3 is to smear sample 2
The skin of hour, Fig. 4 are to smear 4 hours skin of sample.
Interpretation of result：From attached drawing 1- attached drawing 4 this it appears that having smeared the first pure Chinese herbal medicine extract of embodiment 1
Dry skin phenomenon afterwards has obtained great alleviation, and can maintain four hours, and the area B of Fig. 1-Fig. 4 has dry skin journey
It spends lighter than the area A.
Embodiment 13
The present embodiment is the skin elasticity performance of the facial mask of testing example 7, and specific step is as follows：
Principle：Principle is stretched based on suction, generates a negative pressure for one spy of skin inspiration in tested skin surface
In fixed test probe, the depth that skin is sucked into test probe is measured by a contactless optic testing system.
Include the transmitter and receiver of light in test probe, emits light and to receive the ratio between light directly proportional to the depth for being inhaled into skin.
Skin elasticity is judged by the size (indicating with parameter R) of skin retraction after measurement vacuum suction, and R value indicates skin closer to 1
Elasticity is better, can be with the elastic property of this analyzing skin.
Subject：20 people.
Subject's condition：Between 18~50 years old age；Without the high sensitive subjects of constitution.
Reagent and material：Dried noodle paper handkerchief, emgloves, pipettor.
Instrument：German Courage+Khazaka skin elasticity tester MPA-580.
Test parameter：Constant negative pressure mode；Cycle-index 3 times, each 2s, previous second constant negative pressure, the latter second is eliminated negative
Pressure.
Prepare before test：Subject's both hands inner forearm is carried out measured zone and is marked, Experimental Area at least 3cm × 3cm, often
At least 1cm is spaced between a test zone.
Measurement：(experimental group is the facial mask of embodiment 7 to test sample；Matrix group is with embodiment 7, and difference is to remove real
Apply the 5th kind of pure Chinese herbal medicine extract of B component in example 7；Blank group is pure water) single application is carried out by the dosage of 2mg/cm2.
Sample is spread evenly across trial zone using emgloves, is gently patted until absorbing.Daily using once, adhere to using two weeks
Afterwards, measurement result.Probe vertical is touched region to be measured to start to test, until test loop terminates to remove probe.It is each to be measured
Region takes be measured at 3 three points.Test result is shown in Table 5.
5 skin elasticity testing inspection result of table
| R2 mean value | R5 mean value | R7 mean value | |
| Before test： | |||
| Experimental group | 0.8019 | 0.7993 | 0.5670 |
| Matrix group | 0.8207 | 0.8224 | 0.6121 |
| Blank group | 0.8056 | 0.8101 | 0.5907 |
| After test： | |||
| Experimental group | 0.8819 | 0.8632 | 0.6211 |
| Matrix group | 0.8266 | 0.8429 | 0.6310 |
| Blank group | 0.8014 | 0.8149 | 0.6009 |
| Increasing value： | |||
| Experimental group | 0.0997 | 0.0799 | 0.0954 |
| Matrix group | 0.0071 | 0.0249 | 0.0308 |
| Blank value | -0.0052 | 0.0059 | 0.0172 |
Wherein, the parameter and meaning of Courage+Khazaka skin elasticity tester MPA-580 are as follows：
Uf --- the maximum tension amount of skin when negative pressure；
0.1s after Ue --- constant negative pressure is added on skin, the amount of tension of skin；
Ur --- cancel 0.1s after negative pressure, the amount of tension of skin；
Ua --- the recovery value of skin when from cancellation negative pressure to constant negative pressure next time；
R2 --- elastic total amount (Ua/Uf) represents skin elasticity entire change；
R5 --- net bullet amount (Ur/Ue) represents the quick variation of skin elasticity；
R7 --- resilient portion amount of elasticity (Ur/Uf) represents the consolidation degree of skin.
Interpretation of result：It can analyze and obtain from list data, used the skin of experimental group, three elastic parameters all increase
About 9.17%；And the incrementss of matrix group and blank group only have 2.1% and 0.6%.It can be concluded that the facial mask of embodiment 7 has increasing
The effect of adding skin elasticity.
According to the above experiment it is found that pure Chinese herbal medicine extract of the invention made according to the rule of Chinese medicine combination drug it is various
Traditional Chinese medicinal components synergistic combination achievees the effect that synergy, the final each component synergy for realizing pure Chinese herbal medicine extract
Effect.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation.It should be pointed out that for those skilled in the art, without departing from the principle of the present invention, also
Other improvements can be made, these improvement also should be regarded as protection scope of the present invention.
Claims (10)
1. a kind of pure Chinese herbal medicine extract, which is characterized in that be prepared by following raw material is extracted：Dendrobium nobile, ginseng, Radix Astragali,
Radix polygonati officinalis, Selaginella tamariscina and green plum.
2. pure Chinese herbal medicine extract according to claim 1, which is characterized in that the mass percent of the raw material is：
Dendrobium nobile 10%~50%；
Ginseng 5%~40%；
Radix Astragali 5%~40%；
Radix polygonati officinalis 5%~40%；
Selaginella tamariscina 1%~30%；
Green plum 1%~30%.
3. pure Chinese herbal medicine extract according to claim 1, which is characterized in that the mass percent of the raw material is：
Dendrobium nobile 20%~40%；
Ginseng 10%~20%；
Radix Astragali 10%~20%；
Radix polygonati officinalis 10%~20%；
Selaginella tamariscina 2%~10%；
Green plum 2%~10%.
4. a kind of preparation method of pure Chinese herbal medicine extract described in claims 1 to 3 any one, which is characterized in that including
Following steps：
The dendrobium nobile, the ginseng, the Radix Astragali, the radix polygonati officinalis, the Selaginella tamariscina and the green plum are milled by step 1, are mixed
Close object；
The mixture is mixed with extracting solution and is extracted and separating treatment by step 2, obtains pure Chinese herbal medicine extract.
5. the preparation method of pure Chinese herbal medicine extract according to claim 4, which is characterized in that extracted described in step 2
It is extracted for heating extraction, room temperature or low temperature extracts.
6. the preparation method of pure Chinese herbal medicine extract according to claim 4, which is characterized in that the separating treatment is more
Grade membrane separation.
7. pure Chinese herbal medicine extract described in claims 1 to 3 any one is preparing the application in Moisturizer.
8. application according to claim 7, which is characterized in that the skin care item are selected from creme, lotion, aqua, gel, face
One of film and lotion are a variety of.
9. a kind of skin care item, which is characterized in that including the pure Chinese herbal medicine extract as described in claims 1 to 3 any one.
10. skin care item according to claim 9, which is characterized in that according to mass percentage, the pure Chinese herbal medicine is extracted
The additive amount of object is 0.1%~50%.
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