CN103222936B - Dermatologic preparation composition containing Semen Nelumbinis extract - Google Patents
Dermatologic preparation composition containing Semen Nelumbinis extract Download PDFInfo
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- CN103222936B CN103222936B CN201210120486.3A CN201210120486A CN103222936B CN 103222936 B CN103222936 B CN 103222936B CN 201210120486 A CN201210120486 A CN 201210120486A CN 103222936 B CN103222936 B CN 103222936B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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Abstract
The present invention relates to the Dermatologic preparation compositions containing germination Semen Nelumbinis extract, specifically, being related to containing the germination Semen Nelumbinis extract using sub-sigmaritical extraction method extraction, it is possible to provide the Dermatologic preparation composition of significant skin moisture-keeping power improvement.
Description
Technical field
The present invention relates to the Dermatologic preparation compositions containing Semen Nelumbinis extract, specifically, being related to extracting containing lotus seeds
Object, it is possible to provide the Dermatologic preparation composition of significant skin moisturization.
Background technology
Recently in order to solve a variety of chemical substances to the side effect of skin and play skin moisturization, largely develops and contain
There are the Dermatologic preparation compositions such as the cosmetics of natural goods.For this purpose, the present inventor does not make a variety of for the natural goods that the public knows
It is studied for skin preparations for extenal use, to study its application possibility.
Lotus attracts attention.Lotus is that multiple positions such as its root, stem, leaf, fruit are used as food or Chinese medicine to use for a long time,
Therefore it is that a safety has obtained the plant of certification, and its price is very cheap, is had the advantage that as cosmetics.In herbal guiding principle
Described in mesh, lotus can strong human body, prevent various diseases, body is slim and graceful when long-term use, can extend the service life.In pharmacological property book on Chinese herbal medicine
It records, lotus can treat the short wind of the vital organs of the human body, can especially treat the heart, spleen, the short wind of kidney and stomach void, and can
The big qi and blood for mending 12 passages through which vital energy circulates strong can be healthy and strong, and black hair when rice and lotus are cooked congee together when eating, long-lived.Lotus flower is mainly as ornamental
With, but its purposes is not widely studied, and especially leaf contains alkaloid and tannic acid, is used as convergence and hemostat,
It is civil to be additionally operable to treatment bed-wetting.Subterranean stem is also referred to as lotus rhizome, makes containing asparagus fern door acid, edible and as nourishing antasthenic
With.Fruit and seed are effective to gynaecological disease.
It is previous to carry out the research of the cosmetic composition using lotus, but do not carried out the cosmetics group using lotus seeds
Close the research of object.In addition, common lotus extract is to be not separated by the positions such as flower, stem, root, but entirety extracts, so its
Extraction effect is bad, needs to add the other materials in addition to lotus and carrys out supplementary result, so preparation process is complicated.
Patent document：KR published patent the 2011-0115047th
Invention content
The present inventor has found that Semen Nelumbinis extract can be provided to skin safe and be filled by the way that various experiments are repeated
The moistening effect divided, it was found that the extract of the lotus seeds of germination compares the extract for the lotus seeds not germinateed with more outstanding
Moistening effect, and there is more significant moistening effect using the Semen Nelumbinis extract of subcritical method extraction, thus complete this hair
It is bright.
Therefore, the purpose of the present invention is to provide contain germination Semen Nelumbinis extract to have good skin as active ingredient
The Dermatologic preparation composition of moistening effect.
Further it is an object to which the Semen Nelumbinis extract extracted using sub-sigmaritical extraction method is contained as active ingredient
Have and the Dermatologic preparation composition with good skin moisturization.
In order to achieve the above objectives, the present invention provides the Dermatologic preparation composition containing germination Semen Nelumbinis extract.
In addition, in order to assign more good moisture-keeping function to skin, the present invention, which provides to contain, utilizes sub-sigmaritical extraction method
The Dermatologic preparation composition of the Semen Nelumbinis extract of extraction.
The Semen Nelumbinis extract or extracted using the lotus seeds of sub-sigmaritical extraction method extraction that the composition of the present invention contains germination
Object, it is possible to provide more good skin moisturization.
Moreover, the composition of the present invention other than skin moisturization, also there is skin aging to prevent effect, anti-oxidant
Effect, skin elasticity increase effect, wrinkle of skin improvement, the complexion improvement improved by blood circulation, pore and receive
Contracting effect, skin irritatin alleviation effects, dynamic equilibrium improvement effect, elastic improvement, acne improvement, sebum reduce effect
Fruit, skin resurfacing effect, skin wastes cleaning effect, cutin improvement, skin tightening effect, regulating effect etc..
Therefore, composition of the invention can be widely used in cosmetics or field of medicaments.
Description of the drawings
Fig. 1 shows the present invention to face containing Semen Nelumbinis extract, germination Semen Nelumbinis extract, subcritical Semen Nelumbinis extract and Asia
The composition of boundary's germination Semen Nelumbinis extract, the increase of moisture when compared with without containing the wherein composition of any one
Rate.
Fig. 2 indicates facing containing Semen Nelumbinis extract, germination Semen Nelumbinis extract, subcritical Semen Nelumbinis extract and Asia for the present invention
The composition of boundary's germination Semen Nelumbinis extract, TEWL (transepidermal water when compared with without containing the wherein composition of any one
Shunting is lost) measurement result.
Specific implementation mode
The present invention relates to contain Dermatologic preparation composition of the Semen Nelumbinis extract as active ingredient.In addition, the present invention relates to
And Dermatologic preparation composition, wherein Semen Nelumbinis extract contain the supply source as essential fatty acid contain physiological activity object
The gamma-Linolenic acid (γ-linolenic acid) of matter, to provide skin lasting good moistening effect.
Specifically, the Semen Nelumbinis extract used in the present invention is extracted from the seed of lotus flower, preferably germinate
It is extracted in lotus seeds.The lotus seeds of germination state are compared with before germination, containing more to active ingredient necessary to biological phenomena, because
This can provide stronger effect.
Above-mentioned germination lotus seeds can germinate to obtain by the way that lotus seeds to be impregnated to culture in the clean water of 20-25 DEG C of temperature.
At this point, lotus seeds preferably germinate on shell after cut.It is preferred that after impregnating in water, 1-2 water is replaced daily, is cultivated 7-10 days.In vain
It is preferably placed in place of natural lighting.
The preparation method of the Semen Nelumbinis extract used in the present invention is not particularly limited, which includes：It is soaked from lotus seeds
Go out, fried leachate either part or all of concentrate being concentrated to give of its leachate or by its concentrate
The chemical substance itself of the dry stoste prepared and the performance main effect contained in extracting solution.
Specifically, Semen Nelumbinis extract is preferably by sub-sigmaritical extraction method (Subcritical Water Extraction)
Extraction.In the super critical extraction used in the past, the density of supercritical fluid is similar with liquid, viscosity and diffusion coefficient and gas
It is similar.Therefore, it using supercritical fluid as Extraction solvent in use, be easy in the fine pores for penetrating into plant, obtains
Molecular density appropriate is extracted after surrounding the molecule of required substance, obtains the extract of required substance by this method.At this point, can
The substance that supercriticality is used as Extraction solvent is made to first have to meet nontoxicity, and because supercriticality is height
Temperature/high pressure so cannot have explosion hazard, and needs as Extraction solvent to have good solvability.As long as meeting
Above-mentioned condition, any substance can be made supercritical fluid and extract.
On the other hand, the subcritical technology used in the present invention is to be used as solvent in the state of no more than critical point
Extraction solvent obtains effect identical with means of supercritical extraction so according to which kind of solvent selected.It is used as solvent in the present invention
Water.In addition, supercritical carbon dioxide cannot extract polar substances, so needing together to make using organic solvent as secondary solvent
With, but subcritical water has extraordinary extraction performance, and the variation range of operating condition is wide, can implement apolar substance
And the extraction of polar substances.Moreover, when being extracted using subcritical water, reaction can also be hydrolyzed.
According to said extracted method, solid or semisolid reagent is utilized into the dielectric constant of the water of different temperatures and pressure
The variation of (dielectric constant, e), extracts Semen Nelumbinis extract in a short time.Therefore, Semen Nelumbinis extract is utilized
Sub-sigmaritical extraction method extracts, so comparing common solvent extraction method, extraction rate is fast, and is used as Extraction solvent
Water, so without residual organic solvent or heavy metal, to human body and environmentally friendly.On the other hand, it because being low temperature process, can protect
The activity of extract is held, also can extract thermal denaturation substance, technique itself advantageously reduces the separation number of extract, and saves
Preparation expense, the recyclable use of solvent.In addition, according to the extraction conditions of temperature and pressure, may be selected to obtain utility.
The Semen Nelumbinis extract using sub-sigmaritical extraction method used in the present invention is specifically prepared in the following manner.By lotus seeds profit
With sub-critical extraction device in 50-200MPa, preferably under the pressure of 100MPa, lotus seeds, effective component extracting are decomposed.Pressure is small
When 50MPa, cannot abundant effective component extracting, and pressure be more than 200MPa when, relatively high pressure, active ingredient extracted amount increase
And less, so being extracted under the pressure of above range.After extraction, one is filtered in the filter with 1.2 μm of holes
It is secondary, filter in the filter with 0.45 μm of hole primary, primary, removal is filtered in the filter with 0.2 μm of hole
Foreign matter and microorganism obtain subcritical Semen Nelumbinis extract.
In the composition of the present invention, the total amount of relative combination, the lotus of the above-mentioned germination containing 0.01-95.0 weight %
Seed extract preferably comprises 5.0-95.0 weight %, more preferably 10.0-90.0 weight %.This is because above-mentioned active ingredient
Content less than 0.01 weight % when, cannot obtain effect of the ingredient to skin, and when more than 95.0 weight %, cannot be further
Improvement effect reduces its raw material efficiency.
The composition of the present invention is Dermatologic preparation composition, specifically can be used as Hydra skin preparations for extenal use combination
Object, the composition strengthen skin barrier performance, the differentiation of induced skin keratinocyte.Therefore, act effectively as can prevent or
Improve the Dermatologic preparation composition of xerodermia or chronic eczema etc. because caused by epidermal differentiation is incomplete.In addition, it is possible to provide
Skin aging prevents effect, antioxidant effect, skin elasticity from increasing effect, wrinkle of skin improvement, changing by blood circulation
Kind complexion improvement, pore contractive effect, skin irritatin alleviation effects, dynamic equilibrium improvement effect, skin elasticity improve
Effect, acne improvement, skin resurfacing effect, sebum minimizing effect, skin wastes cleaning effect, cutin improvement, skin
Skin tightening effect, regulating effect etc., make skin integrally obtain improvement.
The Dermatologic preparation composition of the present invention is in the form of cosmetics when carrying out dosage form, can be made into soft toner,
Astringent lotion, nutrition toner, eye cream, nourishing cream, massage cream, facial cleanser, foaming mousse cleanser, clean water, powder, essence or facial mask
Etc. forms, dosage form be not particularly limited.The composition of the present invention can contain fatty material, organic solvent, lytic agent, concentration
Agent, gelling agent, softening agent, antioxidant, suspending agent, stabilizer, foaming agent (foaming agent), aromatic, surface-active
Agent, water, ionic or nonionic emulsifier, filler, metal ion disintegrant, chelating agent, preservative agent, vitamin, blocking
It is common arbitrary in agent, wetting agent, required oil, dyestuff, pigment, hydrophily or lipophile activating agent, lipid vesicle and cosmetics
Usually used adjuvant in the cosmeceutical or dermatology of other compositions.The content of above-mentioned adjuvant be cosmeceutical or
Usually used amount in dermatology.In addition, the composition of the present invention can contain skin and absorb rush for skin improvement effects
Into substance.
The composition of the present invention can be pharmaceutical compositions.Above-mentioned pharmaceutical compositions further contain preservative, stabilize
The adjuvant and other treatment of agent, hydrating agents or emulsification promoter, the salt for adjusting osmotic pressure and/or the pharmacies such as buffer
Upper useful substance.
The composition and effect further illustrated the present invention below by embodiment.These embodiments are intended merely to help to this
It's not limited to that for the understanding of invention, scope of the invention and range.
The common Semen Nelumbinis extract of comparative example
The lotus seeds for state of not germinateing are put into the solvent of 70 weight % Purified Waters and 30 weight % ethyl alcohol, are transferred at 25 DEG C
It sets 6 hours, extracts active constituent.After extraction, filtered once, in the mistake with 1 μm of hole in the filter with 3 μm of holes
Primary, elimination foreign matter is filtered in filter, and sterilizing filter, elimination microorganism is finally utilized to obtain common Semen Nelumbinis extract.
The germination Semen Nelumbinis extract of embodiment 1
The lotus seeds for the state of germinateing are put into the solvent of 70 weight % Purified Waters and 30 weight % ethyl alcohol, are placed at 25 DEG C
6 hours, extract active constituent.After extraction, filtered once, in the filtering with 1 μm of hole in the filter with 3 μm of holes
Primary, elimination foreign matter is filtered in device, and sterilizing filter, elimination microorganism is finally utilized to obtain germination Semen Nelumbinis extract.
2 subcritical Semen Nelumbinis extract of embodiment
The lotus seeds for state of not germinateing are utilized into sub-critical extraction device, 4 hours effective component extractings at 40 DEG C, 20MPa.
It after extraction, filters once, is filtered in the filter with 0.45 μm of hole once in the filter with 1.2 μm of holes,
It is filtered in the filter with 0.2 μm of hole once, eliminates foreign matter and microorganism, obtain subcritical Semen Nelumbinis extract.
3 subcritical germination Semen Nelumbinis extract of embodiment
The lotus seeds for the state of germinateing are utilized into sub-critical extraction device, 4 hours effective component extractings at 40 DEG C, 20MPa.It carries
It after taking, filters once, is filtered in the filter with 0.45 μm of hole once in the filter with 1.2 μm of holes,
It is filtered in filter with 0.2 μm of hole once, eliminates foreign matter and microorganism, obtain subcritical germination Semen Nelumbinis extract.
1 moisture of skin vitality of test example measures
Moisture of skin variable quantity and vitality when being applied 1 time to measure, preparation example 1- prepared by the composition of according to the form below 1
3 and comparison preparation example 1-2, evaluates their moisture incrementss using hydro-tester (comeometer).
Table 1
(unit：Weight %)
First, 30 years old or more women 25 is selected, after both sides forearm is cleaned using circulating water, from wrist to 5 centimetres
Position indicates experiment position with the circle of 1.5cm diameters.Subject is keeping 23 ± 1 DEG C and 45 ± 5%RH of constant temperature-humidity room
After interior waiting 30 minutes, using moisture teller (CM825, Courage＆Khazaka, Germany), water is measured with following methods
Divide content.
The assay method of moisture teller
The degree of ionization that amount of moisture in skin epidermis is measured to moisture using sensor after being quantized, calculates
Thus amount of moisture measures moisturizing power.
1, the probe of moisture teller is placed in the skin part for preparing to measure.
2, probe pressing on the skin, by sensor, shows the skin pricktest content of numeralization on picture
(capacitance)。
3, change measurement site, measurement is repeated.
4, it after measuring every time, is measured again after wiping sensor with low dirt cleansing tissue.
Then, same amount of preparation example 1-3 and comparison preparation example 1-2, which is respectively applied, in the experiment position of both sides forearm makes its suction
After receipts, the water of experiment position is measured when being waited for 30 minutes, 1 hour, 2 hours, 4 hours, 6 hours in constant temperature-humidity room respectively
Divide content.When moisture increment rate is coating preparation example 1-3 and comparison preparation example 1-2, the calculating number compared with coating before
Value, average result are shown in table 2 and Fig. 1.
Table 2
| Before coating | 30 minutes | 1 hour | 2 hours | 4 hours | 6 hours | |
| Control group (no coating) | 26.2 | 26.11 | 26.21 | 26.15 | 26.19 | 26.17 |
| Preparation example 1 | 26.34 | 51.99 | 44.63 | 43.39 | 41.13 | 40.58 |
| Preparation example 2 | 26.12 | 51.85 | 44.72 | 43.27 | 41.59 | 39.98 |
| Preparation example 3 | 26.08 | 53.77 | 50.48 | 49.64 | 46.21 | 45.69 |
| Compare preparation example 1 | 26.05 | 48.13 | 43.17 | 39.53 | 38.52 | 33.63 |
| Compare preparation example 2 | 25.92 | 49.95 | 43.54 | 42.87 | 40.25 | 36.14 |
The case where can be seen that the preparation example 1-3 of Semen Nelumbinis extract of the coating containing germination from above-mentioned table 2 and Fig. 1, compares
The prescription of the primary comparison preparation example 1 of coating, can confirm and keep further amounts of moisture to skin.In addition, the preparation example 1-3 of the present invention
The case where, compared to the comparison preparation example 2 for applying common Semen Nelumbinis extract, it can confirm the amount of moisture to last much longer.In particular,
Using it is subcritical germination Semen Nelumbinis extract preparation example 3 the case where, as shown in Figure 1, can confirm with higher than preparation example 1 and prepare
The good moisture of skin vitality of the sum of the effect of example 2.
2 skin moisturization of test example measures
In order to measure long-term skin moisture-keeping power improvement, TEWL (being lost in through transepidermal water) is measured.At this point, using with
1 identical preparation example 1-3 of above-mentioned test example and comparison preparation example 1-2, is tested.
First, the women 30 for selecting 30 years old or more, preparation example 1-3 and comparison preparation example 1-2 is for 4 weeks twice daily
Coated in both sides face, before application, coating after 2 weeks, apply after 4 weeks when, constant temperature and humidity condition (24 DEG C, relative humidity
40%) under, TEWL is measured with following methods.
TEWL assay methods
The moisture of skin evaporation capacity of unit of account area and time passes the amount of moisture of evaporation by temperature and moisturizing electronics
Sensor reads and quantizes, and thus measures the moisturizing power of skin.
1, environmental condition：Stable temperature and humidity is kept, measurement person and subject are only left.At this point, cutting off as far as possible
Air flows.
2, the detector of TEWL is placed on to the measurement site of subject.
It when detector 3, being placed on measurement site, puts down gently, avoids that skin is applied excessive power and generates trace, with ground
Keep an angle of 90 degrees degree.
4, by certain time, the value when TEWL numerical value of skin keeps stablizing measures about 1-3 minutes.
5, the handle of detector is held far as far as possible, and the body temperature of measurement person is avoided to pass to detector.
6, the water evaporation quantity (g/m of unit of account area and time2/h)。
Compare moisturizing power by the TEWL of measurement, the results are shown in Fig. 2.Figure it is seen that the case where preparation example 1-3,
Compared to comparison preparation example 1-2, it can confirm and significantly reduce water evaporation quantity.After 2 weeks, using the comparison system of common Semen Nelumbinis extract
When standby example 2, moisture of skin amount is reduced to about 70%；When using preparation example 1-3 of the invention, moisture of skin keeps 80% or more.
In particular, using it is subcritical germination Semen Nelumbinis extract preparation example 3 when, after 4 weeks, can still keep about 85% skin water
Point, it can confirm good skin moisture-keeping power.
The subjective efficiency evaluation of test example 3
After terminating above-mentioned test example 1 and test example 2, using subject as object, questionnaire, investigation dry skin situation have been formulated
The subjective idea whether improved.Questionnaire inquires that skin is tight, improvement of itch, dermatoglyph and entirety, to system
Standby example 1-3 and comparison preparation example 1-2 are scored with 1 to 10 score.
Table 3
| The tight improvement of skin | Itch improves | Dermatoglyph improves | It is comprehensive to improve | |
| Preparation example 1 | 7 | 6 | 7 | 7 |
| Preparation example 2 | 7 | 6 | 7 | 7 |
| Preparation example 3 | 8 | 8 | 9 | 8 |
| Compare preparation example 1 | 5 | 3 | 4 | 3 |
| Compare preparation example 2 | 5 | 5 | 6 | 5 |
As can be seen from Table 3, the position of coating preparation example 1-3 shows tight skin, itch, dermatoglyph and entirety
On obtained good improvement.But the answer of subject is that when applying comparison preparation example 1-2, do not have to all items
Feel to be obviously improved effect.
Claims (3)
1. purposes of the lotus seeds sub-critical extraction object as active ingredient in preparing skin moisture-keeping preparation composition for external use of germinateing.
2. purposes according to claim 1, wherein the germination lotus seeds sub-critical extraction object contains gamma-Linolenic acid.
3. purposes according to claim 1, wherein the total amount of relative combination, the germination lotus seeds sub-critical extraction object
Content be 10-90 weight %.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2012-0009468 | 2012-01-31 | ||
| KR1020120009468A KR101833274B1 (en) | 2012-01-31 | 2012-01-31 | External composition for skin containing Nelumbo nucifera seed extract |
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| CN103222936A CN103222936A (en) | 2013-07-31 |
| CN103222936B true CN103222936B (en) | 2018-09-14 |
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| CN201210120486.3A Active CN103222936B (en) | 2012-01-31 | 2012-04-23 | Dermatologic preparation composition containing Semen Nelumbinis extract |
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| SG11201805445SA (en) * | 2016-09-13 | 2018-07-30 | Amorepacific Corp | External use skin preparation composition for anti-anging containing germinated glycine gracilis extract as active ingredient |
| KR101908977B1 (en) * | 2017-01-09 | 2018-10-17 | 주식회사 아미코스메틱 | A cosmetic composition for pore-minimizing and sebum control comprising lens esculenta, ceratonia siliqua, nelumbo nucifera and chenopodium quinoa extract |
| CN108358772A (en) * | 2017-12-20 | 2018-08-03 | 湖北工业大学 | A kind of preparation method and applications of spirulina gamma-Linolenic acid extract |
| CN115607489A (en) * | 2022-10-09 | 2023-01-17 | 皓雨(广州)化妆品制造有限公司 | Cosmetic raw material containing germination secretion and preparation method of secretion |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5925348A (en) * | 1996-02-23 | 1999-07-20 | Medical Doctor's Research Institute, Inc. | Methods utilizing compositions containing sacred lotus (methyltransferase) to treat aging skin |
| CN101606980A (en) * | 2008-06-18 | 2009-12-23 | 湖北汇特生物医药技术有限公司 | The application of antimicrobial and antiphlogistic activity composition in lotus (lotus) fruit (Semen Nelumbinis) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005041996A1 (en) * | 2003-10-03 | 2005-05-12 | GREEN MEADOWS RESEARCH, LLC A & L Goodbody | Lotus and methyl donors |
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2012
- 2012-01-31 KR KR1020120009468A patent/KR101833274B1/en active IP Right Grant
- 2012-04-23 CN CN201210120486.3A patent/CN103222936B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5925348A (en) * | 1996-02-23 | 1999-07-20 | Medical Doctor's Research Institute, Inc. | Methods utilizing compositions containing sacred lotus (methyltransferase) to treat aging skin |
| CN101606980A (en) * | 2008-06-18 | 2009-12-23 | 湖北汇特生物医药技术有限公司 | The application of antimicrobial and antiphlogistic activity composition in lotus (lotus) fruit (Semen Nelumbinis) |
Non-Patent Citations (1)
| Title |
|---|
| 亚临界萃取技术在提取花椒籽油中的应用研究;朱刚等;《粮油食品科技》;20101231;第18卷(第4期);第24-26页 * |
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| CN103222936A (en) | 2013-07-31 |
| KR20130088311A (en) | 2013-08-08 |
| KR101833274B1 (en) | 2018-03-02 |
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