CN105596273B - Clear Virgin's milk liquid of a kind of Shu Run and preparation method thereof - Google Patents

Clear Virgin's milk liquid of a kind of Shu Run and preparation method thereof Download PDF

Info

Publication number
CN105596273B
CN105596273B CN201510829840.3A CN201510829840A CN105596273B CN 105596273 B CN105596273 B CN 105596273B CN 201510829840 A CN201510829840 A CN 201510829840A CN 105596273 B CN105596273 B CN 105596273B
Authority
CN
China
Prior art keywords
weight portions
extract
weight
glycerol
emulsion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201510829840.3A
Other languages
Chinese (zh)
Other versions
CN105596273A (en
Inventor
何廷刚
艾勇
朱思阳
邵珠广
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hua An Tang biotech Group Co., Ltd.
Original Assignee
City Flower An Tang Bio Tech Ltd Guangzhou
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by City Flower An Tang Bio Tech Ltd Guangzhou filed Critical City Flower An Tang Bio Tech Ltd Guangzhou
Priority to CN201510829840.3A priority Critical patent/CN105596273B/en
Publication of CN105596273A publication Critical patent/CN105596273A/en
Application granted granted Critical
Publication of CN105596273B publication Critical patent/CN105596273B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin

Abstract

The invention belongs to cosmetic technical field, clear Virgin's milk liquid of specifically related to a kind of Shu Run and preparation method thereof, emulsion of the present invention includes Glycyrrhiza glabra L. root extract, macadimia nut oil, artemia extract, Tremella extract, fragrant citrus berry extract, Sensiva SC50.The whitening composition of the present invention is by screening acquisition, above-mentioned whitening composition is added in cosmetic base, can be very good to reduce the Mai Laning values and Mai Laning contents of skin, absolutely prove that emulsion of the present invention has and suppress melanic effect well, i.e., with good whitening function；In addition, citric acid and sodium citrate are added in whitening emulsion, it is ensured that emulsion intercalation method.

Description

Clear Virgin's milk liquid of a kind of Shu Run and preparation method thereof
Technical field
The invention belongs to cosmetic technical field, and in particular to clear Virgin's milk liquid of a kind of Shu Run and preparation method thereof.
Background technology
Skin-whitening and nursing are the themes of cosmetics, and the cosmetics with skin-whitening and skin-care function are most smooth One of cosmetics of pin.Modern scientific research proves that skin aging is an extremely complex process, by the shadow of many factors Ring, wherein it is two big principal elements that melanic generation and free radical cause the degeneration of elastic fibers of skin.Melanic formation Process is：L-Tyrosine (tyrosine) in human body skin melanocyte is oxidized under the catalytic action of tryrosinase and generates DOPA (dopa) and DOPA quinone (dopaquinone), it is rearranged after further oxidation generate dopachrome (dopachrome), 5, 6- dihydroxy indoles (5,6-dihydroxyindole), istain (indole-5,6-quinone), final synthesis of melanin (melanin).The principal element of melanic formation is affected to have：The quantity of melanocyte, the activity of tryrosinase, oxygen freedom The content of the content and L-Tyrosine of base.Wherein, L-Tyrosine is aminoacid needed by human, and its content is controlled by human body itself 's.So, melanic formation to be controlled, can only pass through to control the quantity of melanocyte, the activity of tryrosinase and oxygen certainly By the content of base.So, from a safety viewpoint for, the approach of skin-whitening and skin nursing mainly has the following aspects： One is by suppressing dermal melanin cell propagation, reducing the quantity that melanocyte is generated；Two is by suppressing skin black The catalysis activity of key enzyme-tryrosinase that element is generated, reaches whitening purpose so as to reduce melanic generating rate；Three is logical Cross sun-proof, prevent injury (tanned and sunburn) of the sunlight middle-ultraviolet lamp to skin, slow down skin aging；Four is by using antioxygen Agent removes the oxygen-derived free radicals in skin, slows down melanin and generates and slow down skin aging.At present, the management of China's skin-lightening cosmetic There is larger defect with technology, the phenomenon of addition is very serious in violation of rules and regulations, have even using the contrabands such as aminomercuric chloride as The peroxide such as whitening agent or addition hydrogen peroxide is bleached, and is caused many beauty accidents for many years, or even is disfeatured, to consumption Person causes very big injury, has caused the great attention of country and consumer.In recent years, the whitening used in cosmetics Agent mainly has hydroquinone (hydroquinone), L-AA (vitamin C), kojic acid, superoxide dismutase (SOD) and arbutin etc. Compound.But these whitening agents have many defects, the zest of such as hydroquinone is very big, and vitamin C and SOD are very unstable Fixed, kojic acid also has certain zest and property easy to change, and arbutin acts on single and effect on driving birds is not good etc..So exploitation is with good Safety, stability, inhibition are obvious, the good natural whitening agent of cost performance, it has also become current medicine and cosmetic industry One of main direction of studying, with extraordinary development prospect.Natural materials be applied to cosmetics can reach skin treating and Skin protection double effects, and there is the characteristic such as vdiverse in function, widely applicable, safe, thus be increasingly subject to pay attention to.Patent of invention CN102225039A disclose it is a kind of containing Radix Glycyrrhizae, Cortex Moutan, Fructus Atriplicis Sibiricae, Rhizoma Polygonati, Herba Leonuri whitening Chinese medicament compositionss, the Chinese medicine Compositionss carry out extraction preparation using decocting method.Patent of invention CN101612105 disclose one kind by the Pseudobulbus Bletillae (Rhizoma Bletillae), in vain hold back, Cortex Mori The whitening and skin-protecting Chinese medicine composition of the extract composition of skin, Poria, Fructus Atriplicis Sibiricae, the Rhizoma Atractylodis Macrocephalae, Fructus Amomi Rotunduss, the Radix Paeoniae Alba, Herba Pyrolae and Radix Angelicae Sinensis Thing and preparation method thereof, said composition adopt soak extraction and the method for anion exchange resin separation and concentration to prepare.Patent of invention CN101732223A disclose it is a kind of by Aloe, Faeces Passeriss, lead a cow in vain, Poria, Semen Ginkgo core, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae, the Rhizoma Atractylodis Macrocephalae, Nidus collocaliae, Semen Coicis, Radix Gentianae, Radix Angelicae Sinensis, the pure Chinese medicine active white skin care solution of Semen Ginkgo composition, the Chinese medicine composition are extracted using decocting method Prepare.Patent of invention CN101804185A discloses a kind of containing Radix Bupleuri, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Fructus Corni, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Chuanxiong, Fructus Persicae The freckle removal traditional Chinese medicinal composition of core, Bombyx Batryticatus, Roast Rhizoma Zingiberis Recens, Herba Menthae and Radix Glycyrrhizae Preparata, the Chinese medicine composition employ super using carbon dioxide Critical abstraction technique is extracted.During above-mentioned Chinese medicine composition adds cosmetic base, although skin-lightening cosmetic thorn can be solved Sharp property, the problem of stability, but these cosmetic appearances are poor, and whitening effect needs longer time, therefore, further study More preferable skin-lightening cosmetic is developed, it is significant.
The content of the invention
For these reasons, applicant obtains a kind of new emulsion through years of researches, in the emulsion containing whitening into Point, whitening composition includes：Glycyrrhiza glabra L. root extract, macadimia nut oil, artemia extract, Tremella extract, Citrus junos fruit are extracted Thing, Sensiva SC50.The present invention whitening composition be by screen obtain, add in cosmetic base above-mentioned whitening into Point, can be very good to reduce the Mai Laning values and Mai Laning contents of skin, absolutely prove that emulsion of the present invention has suppression well Melanic effect is made, i.e., with good whitening function；In addition, citric acid and sodium citrate are added in whitening emulsion, it is ensured that Emulsion intercalation method.
What the present invention was achieved through the following technical solutions.
A kind of emulsion, the emulsion include whitening composition, and wherein whitening composition is：Glycyrrhiza glabra L. root extract, Australia are hard Fruit oil, artemia extract, Tremella extract, fragrant citrus berry extract, Sensiva SC50.
Wherein Glycyrrhiza glabra L. root extract 1-3 weight portions, macadimia nut oil 0.5-1.5 weight portion, artemia extract 0.0001 weight portion, Tremella extract 0.04-0.06 weight portions, 0.000003 weight portion of fragrant citrus berry extract, ethylhexyl are sweet Oily 0.1-0.3 weight portions.
The emulsion includes：1,3 butylene glycol, glycine betaine, 1,2- pentanediols, squalane, polydimethylsiloxane, spermaceti Stearyl alcohol, glycerol, sucrose stearate, sucrose distearate, isononyl isononanoate, 1,2- hexanediol, two (lauramide paddy Glutamine) L-Lysine sodium salt, many acyl group adipate esters -2, caprylyl glycol of double-two glycerol, PEG-45 stearates, beta glucan, ethyl Hexyl glycerol, tocopherol, arginine, polyacrylic acid, hydrolyzed vegetable protein, adenosine triphosphate, sodium chondroitin sulfate, xanthan gum, Hydrolecithin, platinum powder, sodium citrate, citric acid, denatonium benzoate, licorice root extract, macadimia nut oil, artemia are extracted Thing, Tremella extract, fragrant citrus berry extract.
The emulsion includes：1,3 butylene glycol 6-8 weight portions, glycine betaine 4-6 weight portions, 1,2- pentanediol 2-4 weight portions, Squalane 2-4 weight portions, polydimethylsiloxane 2-4 weight portions, cetearyl alcohol 2-3 weight portions, glycerol 1.5-2.5 weight Part, sucrose stearate 0.5-1.5 weight portions, sucrose distearate 0.5-1.5 weight portions, isononyl isononanoate 0.5-0.7 Weight portion, 1,2- hexanediol 0.6-0.8 weight portions, two (lauramide glutamine) L-Lysine sodium salt 0.04-0.06 weight portions, Many -2 0.4-0.6 weight portions of acyl group adipate ester of double-two glycerol, caprylyl glycol 0.07-0.08 weight portions, PEG-45 stearates 0.2-0.4 weight portions, beta glucan 0.001-0.002 weight portions, Sensiva SC50 0.1-0.3 weight portions, tocopherol 0.05- 0.15 weight portion, arginine 0.1-0.3 weight portions, polyacrylic acid 0.1-0.3 weight portions, hydrolyzed vegetable protein 0.002-0.003 Weight portion, adenosine triphosphate 0.002-0.003 weight portion, sodium chondroitin sulfate 0.002-0.003 weight portions, xanthan gum 0.04- 0.06 weight portion, hydrolecithin 0.04-0.06 weight portions, 0.0000002 weight portion of platinum powder, 0.01 weight portion of sodium citrate, 0.003 weight portion of citric acid, 0.00002 weight portion of denatonium benzoate, Glycyrrhiza glabra L. root extract 1-3 weight portions, macadimia nut Seed oil 0.5-1.5 weight portions, 0.0001 weight portion of artemia extract, Tremella extract 0.04-0.06 weight portions, Citrus junos fruit are extracted 0.000003 weight portion of thing.
The preparation method of the emulsion is：
(1) water intaking, glycerol, hydrolecithin, 1,3 butylene glycol, glycine betaine, xanthan gum, polyacrylic acid, ethylhexyl are sweet Oil, tocopherol, 1,2- hexanediol, caprylyl glycol, two (lauramide glutamine) L-Lysine sodium salt, add water phase pot, are heated to 65- After 70 DEG C, stir, in suction vacuum emulsifying machine；
(2) squalane, polydimethylsiloxane, cetearyl alcohol, macadimia nut seed oil, sucrose stearate, sucrose are taken Distearate, isononyl isononanoate, many acyl group adipate esters -2 of double-two glycerol, PEG-45 stearates, tocopherol, add Oil phase pot, is heated to 65-70 DEG C, stirs, in suction vacuum emulsifying machine；
(3) start is uniformly mixed, 30 minutes, 1000rpm/ point, stops stirring, is cooled to 40 DEG C；Add water, sweet Oil, 1,2- hexanediol, 1,2- pentanediols, beta glucan, arginine, 1,3 butylene glycol, hydrolyzed vegetable protein, adenosine triphosphate, Sodium chondroitin sulfate, artemia extract, Tremella extract, platinum powder, sodium citrate, fragrant citrus berry extract, Glycyrrhiza glabra L. root are extracted Thing, citric acid, denatonium benzoate, continue to stir, are cooled to room temperature；Fill, obtains final product.
The Glycyrrhiza glabra L. root extract, macadimia nut oil, artemia extract, Tremella extract and fragrant citrus berry extract exist Prepare the application in skin-lightening cosmetic.
Glycyrrhiza glabra L. (GLYCYRRHIZA GLABRA) root extract, purchased from OLI Enterprises, lot number 2014082703。
Macadimia nut (MACADAMIA TERNIFOLIA) oil, purchased from Northstar Lipids, lot number MNOCBFCL3500608。
Tremella (TREMELLA FUCIFORMIS) extract, purchased from brightness text, lot number 150801.The artemia (ARTEMIA) extract, purchased from ISP, lot number 5001912450.
Fragrant citrus (CITRUS JUNOS) berry extract, purchased from ICHIMARU, lot number 150934。
Specific embodiment
The present invention is elaborated with reference to example.Following examples are not limited to protection scope of the present invention.
Following tests, are on the basis of repeatedly creative test, for claimed content of the invention, the knot for carrying out By property test.
First, screening test
Test 1 group：Glycyrrhiza glabra L. root extract 2g, macadimia nut oil 1g.
Test 2 groups：Glycyrrhiza glabra L. root extract 2g, macadimia nut oil 1g, Tremella extract 0.05g.
Test 3 groups：Glycyrrhiza glabra L. root extract 2g, macadimia nut oil 1g, artemia extract 0.0001g, Tremella extract 0.05g, fragrant citrus berry extract 0.000003g, Sensiva SC50 0.2g.
Test 4 groups：Glycyrrhiza glabra L. root extract 2g, macadimia nut oil 1g, artemia extract 0.001g, Tremella extract 0.05g, fragrant citrus berry extract 0.00003g, Sensiva SC50 0.2g.
Test 5 groups：Glycyrrhiza glabra L. root extract 2g, macadimia nut oil 1g, artemia extract 0.1g, Tremella extract 0.05g, fragrant citrus berry extract 0.3g, Sensiva SC50 0.2g.
Test specimen is prepared：1,3 butylene glycol 5g is taken, add water 5g, mixing is complete.1 group of raw material of test is taken, is added above-mentioned molten In agent, mixing is complete, standby；2 groups -5 groups of test is tested, compound method is ibid.
Test method：Take human body skin threedimensional model test box (MEL-300B).According to the test operation flow process by three-dimensional Model is moved in 6 porocyte culture plates, maintains culture medium (EPI-100LLMM) to be placed in 37 DEG C with long-term, 5%CO2Lower calorstat After preculture 1 hour, the test specimen of different tests group is added, and addition respectively prepares 100 μ L of test specimen to horny layer side, Blank group adds the 1,3 butylene glycol aqueous solution (50%) of equivalent.Basal layer side maintains culture medium to continue culture using long-term.2 days Or the interval of 3 days exchanges the culture that culture medium and tested material are carried out 16 days altogether.After culture, skin histology is washed with PBS (-) buffering Afterwards, the Mai Laning values of different groups are tested using MX18 (manufacture of Courage+Khazaka companies).
Result of the test：It is shown in Table 1.
The Mai Laning values of 1 different tests group of table
Test group Mai Laning values (a.u.)
Blank group 493.2±1.9
Test 1 group 389.1±0.8**
Test 2 groups 374.5±0.7**
Test 3 groups 302.1±1.2***
Test 4 groups 312.7±0.8***
Test 5 groups 305.4±1.0***
Note：Compare * * P with blank group<0.01, * * * P<0.001.
Conclusion (of pressure testing)：Known Mai Laning values are lower, illustrate to suppress melanic ability stronger；Above-mentioned test data shows, 1 group is tested () after Glycyrrhiza glabra L. root extract and macadimia nut oil combination to can be very good to suppress melanin, add Tremella to extract After thing, whitening effect is not improved, but adds micro artemia extract and fragrant citrus berry extract and Sensiva SC50 Afterwards, Mai Laning values are substantially reduced and (compare P with blank group<0.001), but by the amount of artemia extract and fragrant citrus berry extract increase Afterwards, the melanic ability that suppresses further is not improved, therefore, applicant have determined that the compositionss of 3 groups of test are whitening composition.
2nd, checking test
Test 1 group：1,3 butylene glycol 6g, glycine betaine 4g, 1,2- pentanediol 2g, squalane 2g, polydimethylsiloxane 2g, Cetearyl alcohol 2g, glycerol 1.5g, sucrose stearate 0.5g, sucrose distearate 0.5g, isononyl isononanoate 0.5g, 1, The many acyl group adipate esters of 2- hexanediol 0.6g, two (lauramide glutamine) L-Lysine sodium salt 0.04g, double-two glycerol -2 0.4g, caprylyl glycol 0.07g, PEG-45 stearate 0.2g, beta glucan 0.001g, Sensiva SC50 0.1g, tocopherol 0.05g, arginine 0.1g, polyacrylic acid 0.1g, hydrolyzed vegetable protein 0.002g, adenosine triphosphate 0.002g, chondroitin sulfate Sodium 0.002g, xanthan gum 0.04g, hydrolecithin 0.04g, platinum powder 0.0000002g, sodium citrate 0.01g, citric acid 0.003g, denatonium benzoate 0.00002g, Glycyrrhiza glabra L. root extract 1g, macadimia nut seed oil 0.5g, artemia extract 0.0001g, Tremella extract 0.04g, fragrant citrus berry extract 0.000003g.
Preparation method：(1) fetch water 55g, glycerol 0.7g, hydrolecithin, 1,3 butylene glycol 3g, glycine betaine, xanthan gum, poly- Acrylic acid, Sensiva SC50, tocopherol 0.02g, 1,2- hexanediol 0.3g, caprylyl glycol, two (lauramide glutamine) rely Propylhomoserin sodium, adds water phase pot, after being heated to 65-70 DEG C, stirs, in suction vacuum emulsifying machine；
(2) squalane, polydimethylsiloxane, cetearyl alcohol, macadimia nut seed oil, sucrose stearate, sucrose are taken Distearate, isononyl isononanoate, many acyl group adipate esters -2 of double-two glycerol, PEG-45 stearates, tocopherol 0.03g, Oil phase pot is added, 65-70 DEG C is heated to, is stirred, in suction vacuum emulsifying machine；
(3) start is uniformly mixed, 30 minutes, 1000rpm/ point, stops stirring, is cooled to 40 DEG C；Add water 5g, sweet Oily 0.8g, 1,2- hexanediol 0.3g, 1,2- pentanediol, beta glucan, arginine, 1,3 butylene glycol 3g, hydrolyzed vegetable protein, three Adenosine phosphate, sodium chondroitin sulfate, artemia extract, Tremella extract, platinum powder, sodium citrate, fragrant citrus berry extract, light fruit are sweet Grass roots extract, citric acid, denatonium benzoate, continue to stir, are cooled to room temperature；Fill, obtains final product.
Test 2 groups：1,3 butylene glycol 7g, glycine betaine 5g, 1,2- pentanediol 3g, squalane 3g, polydimethylsiloxane 3g, Cetearyl alcohol 2.5g, glycerol 2g, sucrose stearate 1g, sucrose distearate 1g, isononyl isononanoate 0.6g, 1,2- oneself It is glycol 0.7g, two (lauramide glutamine) L-Lysine sodium salt 0.05g, many -2 0.5g of acyl group adipate ester of double-two glycerol, pungent Glycol 0.075g, PEG-45 stearate 0.3g, beta glucan 0.0015g, Sensiva SC50 0.2g, tocopherol 0.1g, essence Propylhomoserin 0.2g, polyacrylic acid 0.2g, hydrolyzed vegetable protein 0.0025, adenosine triphosphate 0.0025g, sodium chondroitin sulfate 0.0025g, xanthan gum 0.05g, hydrolecithin 0.05g, platinum powder 0.0000002g, sodium citrate 0.01g, citric acid 0.003g, denatonium benzoate 0.00002g, Glycyrrhiza glabra L. root extract 2g, macadimia nut seed oil 1g, artemia extract 0.0001g, Tremella extract 0.05g, fragrant citrus berry extract 0.000003g.
Preparation method：(1) fetch water 62g, glycerol 1g, hydrolecithin, 1,3 butylene glycol 3.5g, glycine betaine, xanthan gum, poly- Acrylic acid, Sensiva SC50, tocopherol 0.05g, 1,2- hexanediol 0.35g, caprylyl glycol, two (lauramide glutamine) rely Propylhomoserin sodium, adds water phase pot, after being heated to 65-70 DEG C, stirs, in suction vacuum emulsifying machine；
(2) squalane, polydimethylsiloxane, cetearyl alcohol, macadimia nut seed oil, sucrose stearate, sucrose are taken Distearate, isononyl isononanoate, many acyl group adipate esters -2 of double-two glycerol, PEG-45 stearates, tocopherol 0.05g, Oil phase pot is added, 65-70 DEG C is heated to, is stirred, in suction vacuum emulsifying machine；
(3) start is uniformly mixed, 30 minutes, 1000rpm/ point, stops stirring, is cooled to 40 DEG C；Add water 9g, sweet Oily 1g, 1,2- hexanediol 0.35g, 1,2- pentanediol, beta glucan, arginine, 1,3 butylene glycol 3.5g, hydrolyzed vegetable protein, Adenosine triphosphate, sodium chondroitin sulfate, artemia extract, Tremella extract, platinum powder, sodium citrate, fragrant citrus berry extract, light fruit Licorice root extract, citric acid, denatonium benzoate, continue to stir, are cooled to room temperature；Fill, obtains final product.
Test 3 groups：1,3 butylene glycol 8g, glycine betaine 6g, 1,2- pentanediol 4g, squalane 4g, polydimethylsiloxane 4g, Cetearyl alcohol 3g, glycerol 2.5g, sucrose stearate 1.5g, sucrose distearate 1.5g, isononyl isononanoate 0.7g, 1, The many acyl group adipate esters of 2- hexanediol 0.8g, two (lauramide glutamine) L-Lysine sodium salt 0.06g, double-two glycerol -2 0.6g, caprylyl glycol 0.08g, PEG-45 stearate 0.4g, beta glucan 0.002g, Sensiva SC50 0.3g, tocopherol 0.15g, arginine 0.3g, polyacrylic acid 0.3g, hydrolyzed vegetable protein 0.003g, adenosine triphosphate 0.003g, chondroitin sulfate Sodium 0.003g, xanthan gum 0.06g, hydrolecithin 0.06g, platinum powder 0.0000002g, sodium citrate 0.01g, citric acid 0.003g, denatonium benzoate 0.00002g, Glycyrrhiza glabra L. root extract 2g, macadimia nut seed oil 1g, artemia extract 0.0001g, Tremella extract 0.05g, fragrant citrus berry extract 0.000003g.
Preparation method：(1) fetch water 70g, glycerol 1.2g, hydrolecithin, 1,3 butylene glycol 4g, glycine betaine, xanthan gum, poly- Acrylic acid, Sensiva SC50, tocopherol 0.07g, 1,2- hexanediol 0.4g, caprylyl glycol, two (lauramide glutamine) rely Propylhomoserin sodium, adds water phase pot, after being heated to 65-70 DEG C, stirs, in suction vacuum emulsifying machine；
(2) squalane, polydimethylsiloxane, cetearyl alcohol, macadimia nut seed oil, sucrose stearate, sucrose are taken Distearate, isononyl isononanoate, many acyl group adipate esters -2 of double-two glycerol, PEG-45 stearates, tocopherol 0.08g, Oil phase pot is added, 65-70 DEG C is heated to, is stirred, in suction vacuum emulsifying machine；
(3) start is uniformly mixed, 30 minutes, 1000rpm/ point, stops stirring, is cooled to 40 DEG C；Addition water 11g, Glycerol 1.3g, 1,2- hexanediol 0.4g, 1,2- pentanediol, beta glucan, arginine, 1,3 butylene glycol 4g, hydrolyzed vegetable protein, Adenosine triphosphate, sodium chondroitin sulfate, artemia extract, Tremella extract, platinum powder, sodium citrate, fragrant citrus berry extract, light fruit Licorice root extract, citric acid, denatonium benzoate, continue to stir, are cooled to room temperature；Fill, obtains final product.
Blank group：1,3 butylene glycol 7g, glycine betaine 5g, 1,2- pentanediol 3g, squalane 3g, polydimethylsiloxane 3g, Cetearyl alcohol 2.5g, glycerol 2g, sucrose stearate 1g, sucrose distearate 1g, isononyl isononanoate 0.6g, 1,2- oneself It is glycol 0.7g, two (lauramide glutamine) L-Lysine sodium salt 0.05g, many -2 0.5g of acyl group adipate ester of double-two glycerol, pungent Glycol 0.075g, PEG-45 stearate 0.3g, beta glucan 0.0015g, Sensiva SC50 0.2g, tocopherol 0.1g, essence Propylhomoserin 0.2g, polyacrylic acid 0.2g, hydrolyzed vegetable protein 0.0025, adenosine triphosphate 0.0025g, sodium chondroitin sulfate 0.0025g, xanthan gum 0.05g, hydrolecithin 0.05g, platinum powder 0.0000002g, sodium citrate 0.01g, citric acid 0.003g, denatonium benzoate 0.00002g.
Preparation method：(1) fetch water 62g, glycerol 1g, hydrolecithin, 1,3 butylene glycol 3.5g, glycine betaine, xanthan gum, poly- Acrylic acid, Sensiva SC50, tocopherol 0.05g, 1,2- hexanediol 0.35g, caprylyl glycol, two (lauramide glutamine) rely Propylhomoserin sodium, adds water phase pot, after being heated to 65-70 DEG C, stirs, in suction vacuum emulsifying machine；
(2) take squalane, polydimethylsiloxane, cetearyl alcohol, sucrose stearate, sucrose distearate, different The different nonyl ester of n-nonanoic acid, many acyl group adipate esters -2 of double-two glycerol, PEG-45 stearates, tocopherol 0.05g, add oil phase pot, plus Heat stirs, in suction vacuum emulsifying machine to 65-70 DEG C；
(3) start is uniformly mixed, 30 minutes, 1000rpm/ point, stops stirring, is cooled to 40 DEG C；Add water 9g, sweet Oily 1g, 1,2- hexanediol 0.35g, 1,2- pentanediol, beta glucan, arginine, 1,3 butylene glycol 3.5g, hydrolyzed vegetable protein, Adenosine triphosphate, sodium chondroitin sulfate, platinum powder, sodium citrate, citric acid, denatonium benzoate, continue to stir, are cooled to room Temperature；Fill, obtains final product.
Checking test 1：According to a screening test is tested, the Mai Laning values of different groups are determined.
Result of the test：It is shown in Table 2.
The Mai Laning values of 2 different emulsions of table compare
Test group Mai Laning values (a.u.)
Blank group 477.9±1.1
Test 1 group 309.8±1.0***
Test 2 groups 304.1±1.4***
Test 3 groups 312.4±0.9***
Note：Compare * * P with blank group<0.01, * * * P<0.001.
Checking test 2：Mai Laning assays
The quantitative approach of Mai Laning is operated by following procedure：Take skin after above-mentioned test, with tweezers by skin peeling after, put Implement in the 1.0%SDS solution (containing 10mMTris-HCl, 0.05mM EDTA, pH6.8) for entering 450 μ L ultrasound it is broken after, add Plus the 20 μ L of pronase e solution of 5mg/mL, heat 12 hours under the conditions of 45 DEG C.In the 500mM Na for adding 50 μ L2CO3With The 30%H of 10 μ L2O2After be placed in 80 DEG C under the conditions of heat 30 minutes.After cooling, the chloroform of 100 μ L is added：Methanol (2：1) mix Liquid is stirred, and its 100 μ L spectrogrph of supernatant is taken after centrifugation in 10 minutes carries out measurement when wavelength is 405nm.Simultaneously Standard curve is equally measured and is made as standard sample by the use of synthesis Mai Laning (SIGMA), and establishing criteria curve is to skin Contained Mai Laning in skin tissue is carried out quantitatively.
Result of the test：It is shown in Table 3.
3 Mai Laning content quantitative results of table
Note：Compare * * P with blank group<0.01.
Conclusion (of pressure testing)：Above-mentioned test shows, emulsion of the present invention has and suppresses melanic effect well.
3rd, stability test
Test 1 group：1,3 butylene glycol 7g, glycine betaine 5g, 1,2- pentanediol 3g, squalane 3g, polydimethylsiloxane 3g, Cetearyl alcohol 2.5g, glycerol 2g, sucrose stearate 1g, sucrose distearate 1g, isononyl isononanoate 0.6g, 1,2- oneself It is glycol 0.7g, two (lauramide glutamine) L-Lysine sodium salt 0.05g, many -2 0.5g of acyl group adipate ester of double-two glycerol, pungent Glycol 0.075g, PEG-45 stearate 0.3g, beta glucan 0.0015g, Sensiva SC50 0.2g, tocopherol 0.1g, essence Propylhomoserin 0.2g, polyacrylic acid 0.2g, hydrolyzed vegetable protein 0.0025, adenosine triphosphate 0.0025g, sodium chondroitin sulfate 0.0025g, xanthan gum 0.05g, hydrolecithin 0.05g, platinum powder 0.0000002g, sodium citrate 0.01g, citric acid 0.003g, denatonium benzoate 0.00002g, Glycyrrhiza glabra L. root extract 2g, macadimia nut seed oil 1g, artemia extract 0.0001g, Tremella extract 0.05g, fragrant citrus berry extract 0.000003g.
Preparation method：(1) fetch water 62g, glycerol 1g, hydrolecithin, 1,3 butylene glycol 3.5g, glycine betaine, xanthan gum, poly- Acrylic acid, Sensiva SC50, tocopherol 0.05g, 1,2- hexanediol 0.35g, caprylyl glycol, two (lauramide glutamine) rely Propylhomoserin sodium, adds water phase pot, after being heated to 65-70 DEG C, stirs, in suction vacuum emulsifying machine；
(2) squalane, polydimethylsiloxane, cetearyl alcohol, macadimia nut seed oil, sucrose stearate, sucrose are taken Distearate, isononyl isononanoate, many acyl group adipate esters -2 of double-two glycerol, PEG-45 stearates, tocopherol 0.05g, Oil phase pot is added, 65-70 DEG C is heated to, is stirred, in suction vacuum emulsifying machine；
(3) start is uniformly mixed, 30 minutes, 1000rpm/ point, stops stirring, is cooled to 40 DEG C；Add water 9g, sweet Oily 1g, 1,2- hexanediol 0.35g, 1,2- pentanediol, beta glucan, arginine, 1,3 butylene glycol 3.5g, hydrolyzed vegetable protein, Adenosine triphosphate, sodium chondroitin sulfate, artemia extract, Tremella extract, platinum powder, sodium citrate, fragrant citrus berry extract, light fruit Licorice root extract, citric acid, denatonium benzoate, continue to stir, are cooled to room temperature；Fill, obtains final product.
Test 2 groups：1,3 butylene glycol 7g, glycine betaine 5g, 1,2- pentanediol 3g, squalane 3g, polydimethylsiloxane 3g, Cetearyl alcohol 2.5g, glycerol 2g, sucrose stearate 1g, sucrose distearate 1g, isononyl isononanoate 0.6g, 1,2- oneself It is glycol 0.7g, two (lauramide glutamine) L-Lysine sodium salt 0.05g, many -2 0.5g of acyl group adipate ester of double-two glycerol, pungent Glycol 0.075g, PEG-45 stearate 0.3g, beta glucan 0.0015g, Sensiva SC50 0.2g, tocopherol 0.1g, essence Propylhomoserin 0.2g, polyacrylic acid 0.2g, hydrolyzed vegetable protein 0.0025, adenosine triphosphate 0.0025g, sodium chondroitin sulfate 0.0025g, xanthan gum 0.05g, hydrolecithin 0.05g, platinum powder 0.0000002g, denatonium benzoate 0.00002g, light fruit are sweet Grass roots extract 2g, macadimia nut seed oil 1g, artemia extract 0.0001g, Tremella extract 0.05g, fragrant citrus berry extract 0.000003g。
Preparation method：(1) fetch water 62g, glycerol 1g, hydrolecithin, 1,3 butylene glycol 3.5g, glycine betaine, xanthan gum, poly- Acrylic acid, Sensiva SC50, tocopherol 0.05g, 1,2- hexanediol 0.35g, caprylyl glycol, two (lauramide glutamine) rely Propylhomoserin sodium, adds water phase pot, after being heated to 65-70 DEG C, stirs, in suction vacuum emulsifying machine；
(2) squalane, polydimethylsiloxane, cetearyl alcohol, macadimia nut seed oil, sucrose stearate, sucrose are taken Distearate, isononyl isononanoate, many acyl group adipate esters -2 of double-two glycerol, PEG-45 stearates, tocopherol 0.05g, Oil phase pot is added, 65-70 DEG C is heated to, is stirred, in suction vacuum emulsifying machine；
(3) start is uniformly mixed, 30 minutes, 1000rpm/ point, stops stirring, is cooled to 40 DEG C；Add water 9g, sweet Oily 1g, 1,2- hexanediol 0.35g, 1,2- pentanediol, beta glucan, arginine, 1,3 butylene glycol 3.5g, hydrolyzed vegetable protein, Adenosine triphosphate, sodium chondroitin sulfate, artemia extract, Tremella extract, platinum powder, fragrant citrus berry extract, Glycyrrhiza glabra L. root are carried Thing, denatonium benzoate are taken, is continued to stir, is cooled to room temperature；Fill, obtains final product.
Test method：Emulsion is taken, 40 DEG C of storage 24h is placed in, 24h is deposited in room temperature, then at -5 DEG C of storage 24h, follow successively Ring 3 times, has seen whether whether layering, oil slick, color and luster change.
Conclusion (of pressure testing)：It is shown in Table 4.
4 stability test result of table
Group Whether it is layered Whether oil slick Whether color and luster changes
Test 1 group It is no It is no It is no
Test 2 groups Have Have It is no
Conclusion (of pressure testing)：After citric acid and sodium citrate are added without in emulsion, emulsion produces layering after cold cycling With oil slick phenomenon, and test 1 group do not produce such phenomenon, absolutely prove that emulsion prescription stability of the present invention is preferable.
Prepare embodiment
Embodiment 1
1,3 butylene glycol 6g, glycine betaine 4g, 1,2- pentanediol 2g, squalane 2g, polydimethylsiloxane 2g, cetearyl alcohol Alcohol 2g, glycerol 1.5g, sucrose stearate 0.5g, sucrose distearate 0.5g, isononyl isononanoate 0.5g, 1,2- hexanediol 0.6g, two (lauramide glutamine) L-Lysine sodium salt 0.04g, many -2 0.4g of acyl group adipate ester of double-two glycerol, caprylyl glycol 0.07g, PEG-45 stearate 0.2g, beta glucan 0.001g, Sensiva SC50 0.1g, tocopherol 0.05g, arginine 0.1g, polyacrylic acid 0.1g, hydrolyzed vegetable protein 0.002g, adenosine triphosphate 0.002g, sodium chondroitin sulfate 0.002g, xanthan Glue 0.04g, hydrolecithin 0.04g, platinum powder 0.0000002g, sodium citrate 0.01g, citric acid 0.003g, denatonium benzoate 0.00002g, Glycyrrhiza glabra L. root extract 1g, macadimia nut seed oil 0.5g, artemia extract 0.0001g, Tremella extract 0.04g, fragrant citrus berry extract 0.000003g.
Preparation method：(1) fetch water 55g, glycerol 0.7g, hydrolecithin, 1,3 butylene glycol 3g, glycine betaine, xanthan gum, poly- Acrylic acid, Sensiva SC50, tocopherol 0.02g, 1,2- hexanediol 0.3g, caprylyl glycol, two (lauramide glutamine) rely Propylhomoserin sodium, adds water phase pot, after being heated to 65-70 DEG C, stirs, in suction vacuum emulsifying machine；
(2) squalane, polydimethylsiloxane, cetearyl alcohol, macadimia nut seed oil, sucrose stearate, sucrose are taken Distearate, isononyl isononanoate, many acyl group adipate esters -2 of double-two glycerol, PEG-45 stearates, tocopherol 0.03g, Oil phase pot is added, 65-70 DEG C is heated to, is stirred, in suction vacuum emulsifying machine；
(3) start is uniformly mixed, 30 minutes, 1000rpm/ point, stops stirring, is cooled to 40 DEG C；Add water 5g, sweet Oily 0.8g, 1,2- hexanediol 0.3g, 1,2- pentanediol, beta glucan, arginine, 1,3 butylene glycol 3g, hydrolyzed vegetable protein, three Adenosine phosphate, sodium chondroitin sulfate, artemia extract, Tremella extract, platinum powder, sodium citrate, fragrant citrus berry extract, light fruit are sweet Grass roots extract, citric acid, denatonium benzoate, continue to stir, are cooled to room temperature；Fill, obtains final product.
Embodiment 2
1,3 butylene glycol 7g, glycine betaine 5g, 1,2- pentanediol 3g, squalane 3g, polydimethylsiloxane 3g, cetearyl alcohol Alcohol 2.5g, glycerol 2g, sucrose stearate 1g, sucrose distearate 1g, isononyl isononanoate 0.6g, 1,2- hexanediol 0.7g, two (lauramide glutamine) L-Lysine sodium salt 0.05g, many -2 0.5g of acyl group adipate ester of double-two glycerol, caprylyl glycol 0.075g, PEG-45 stearate 0.3g, beta glucan 0.0015g, Sensiva SC50 0.2g, tocopherol 0.1g, arginine 0.2g, polyacrylic acid 0.2g, hydrolyzed vegetable protein 0.0025, adenosine triphosphate 0.0025g, sodium chondroitin sulfate 0.0025g, Huang Virgin rubber 0.05g, hydrolecithin 0.05g, platinum powder 0.0000002g, sodium citrate 0.01g, citric acid 0.003g, benzene first ground that Ammonium 0.00002g, Glycyrrhiza glabra L. root extract 2g, macadimia nut seed oil 1g, artemia extract 0.0001g, Tremella extract 0.05g, fragrant citrus berry extract 0.000003g.
Preparation method：(1) fetch water 62g, glycerol 1g, hydrolecithin, 1,3 butylene glycol 3.5g, glycine betaine, xanthan gum, poly- Acrylic acid, Sensiva SC50, tocopherol 0.05g, 1,2- hexanediol 0.35g, caprylyl glycol, two (lauramide glutamine) rely Propylhomoserin sodium, adds water phase pot, after being heated to 65-70 DEG C, stirs, in suction vacuum emulsifying machine；
(2) squalane, polydimethylsiloxane, cetearyl alcohol, macadimia nut seed oil, sucrose stearate, sucrose are taken Distearate, isononyl isononanoate, many acyl group adipate esters -2 of double-two glycerol, PEG-45 stearates, tocopherol 0.05g, Oil phase pot is added, 65-70 DEG C is heated to, is stirred, in suction vacuum emulsifying machine；
(3) start is uniformly mixed, 30 minutes, 1000rpm/ point, stops stirring, is cooled to 40 DEG C；Add water 9g, sweet Oily 1g, 1,2- hexanediol 0.35g, 1,2- pentanediol, beta glucan, arginine, 1,3 butylene glycol 3.5g, hydrolyzed vegetable protein, Adenosine triphosphate, sodium chondroitin sulfate, artemia extract, Tremella extract, platinum powder, sodium citrate, fragrant citrus berry extract, light fruit Licorice root extract, citric acid, denatonium benzoate, continue to stir, are cooled to room temperature；Fill, obtains final product.
Embodiment 3
1,3 butylene glycol 8g, glycine betaine 6g, 1,2- pentanediol 4g, squalane 4g, polydimethylsiloxane 4g, cetearyl alcohol Alcohol 3g, glycerol 2.5g, sucrose stearate 1.5g, sucrose distearate 1.5g, isononyl isononanoate 0.7g, 1,2- hexanediol 0.8g, two (lauramide glutamine) L-Lysine sodium salt 0.06g, many -2 0.6g of acyl group adipate ester of double-two glycerol, caprylyl glycol 0.08g, PEG-45 stearate 0.4g, beta glucan 0.002g, Sensiva SC50 0.3g, tocopherol 0.15g, arginine 0.3g, polyacrylic acid 0.3g, hydrolyzed vegetable protein 0.003g, adenosine triphosphate 0.003g, sodium chondroitin sulfate 0.003g, xanthan Glue 0.06g, hydrolecithin 0.06g, platinum powder 0.0000002g, sodium citrate 0.01g, citric acid 0.003g, denatonium benzoate 0.00002g, Glycyrrhiza glabra L. root extract 2g, macadimia nut seed oil 1g, artemia extract 0.0001g, Tremella extract 0.05g, Fragrant citrus berry extract 0.000003g.
Preparation method：(1) fetch water 70g, glycerol 1.2g, hydrolecithin, 1,3 butylene glycol 4g, glycine betaine, xanthan gum, poly- Acrylic acid, Sensiva SC50, tocopherol 0.07g, 1,2- hexanediol 0.4g, caprylyl glycol, two (lauramide glutamine) rely Propylhomoserin sodium, adds water phase pot, after being heated to 65-70 DEG C, stirs, in suction vacuum emulsifying machine；
(2) squalane, polydimethylsiloxane, cetearyl alcohol, macadimia nut seed oil, sucrose stearate, sucrose are taken Distearate, isononyl isononanoate, many acyl group adipate esters -2 of double-two glycerol, PEG-45 stearates, tocopherol 0.08g, Oil phase pot is added, 65-70 DEG C is heated to, is stirred, in suction vacuum emulsifying machine；
(3) start is uniformly mixed, 30 minutes, 1000rpm/ point, stops stirring, is cooled to 40 DEG C；Addition water 11g, Glycerol 1.3g, 1,2- hexanediol 0.4g, 1,2- pentanediol, beta glucan, arginine, 1,3 butylene glycol 4g, hydrolyzed vegetable protein, Adenosine triphosphate, sodium chondroitin sulfate, artemia extract, Tremella extract, platinum powder, sodium citrate, fragrant citrus berry extract, light fruit Licorice root extract, citric acid, denatonium benzoate, continue to stir, are cooled to room temperature；Fill, obtains final product.
Prepare embodiment including but not limited to above-mentioned.

Claims (2)

1. a kind of emulsion, it is characterised in that emulsion includes：1,3 butylene glycol 6-8 weight portions, glycine betaine 4-6 weight portions, 1,2- penta It is glycol 2-4 weight portions, squalane 2-4 weight portions, polydimethylsiloxane 2-4 weight portions, cetearyl alcohol 2-3 weight portions, sweet Oily 1.5-2.5 weight portions, sucrose stearate 0.5-1.5 weight portions, sucrose distearate 0.5-1.5 weight portions, different n-nonanoic acid Different nonyl ester 0.5-0.7 weight portions, 1,2- hexanediol 0.6-0.8 weight portions, two (lauramide glutamine) L-Lysine sodium salt 0.04- Many -2 0.4-0.6 weight portions of acyl group adipate ester of 0.06 weight portion, double-two glycerol, caprylyl glycol 0.07-0.08 weight portions, PEG- 45 stearate 0.2-0.4 weight portions, beta glucan 0.001-0.002 weight portions, Sensiva SC50 0.1-0.3 weight portions, Tocopherol 0.05-0.15 weight portions, arginine 0.1-0.3 weight portions, polyacrylic acid 0.1-0.3 weight portions, hydrolyzed vegetable protein 0.002-0.003 weight portions, adenosine triphosphate 0.002-0.003 weight portion, sodium chondroitin sulfate 0.002-0.003 weight portions, Xanthan gum 0.04-0.06 weight portions, hydrolecithin 0.04-0.06 weight portions, 0.0000002 weight portion of platinum powder, sodium citrate 0.01 weight portion, 0.003 weight portion of citric acid, 0.00002 weight portion of denatonium benzoate, Glycyrrhiza glabra L. root extract 1-3 weight Part, macadimia nut seed oil 0.5-1.5 weight portions, 0.0001 weight portion of artemia extract, Tremella extract 0.04-0.06 weight Part, 0.000003 weight portion of fragrant citrus berry extract.
2. a kind of emulsion according to claim 1, it is characterised in that the preparation method of emulsion is：
(1) water intaking, glycerol, hydrolecithin, 1,3 butylene glycol, glycine betaine, xanthan gum, polyacrylic acid, Sensiva SC50, life Phenol, 1,2- hexanediol, caprylyl glycol, two (lauramide glutamine) L-Lysine sodium salt are educated, water phase pot is added, is heated to 65-70 DEG C Afterwards, stir, in suction vacuum emulsifying machine；
(2) squalane, polydimethylsiloxane, cetearyl alcohol, macadimia nut seed oil, sucrose stearate, sucrose two are taken hard Fat acid ester, isononyl isononanoate, many acyl group adipate esters -2 of double-two glycerol, PEG-45 stearates, tocopherol, add oil phase Pot, is heated to 65-70 DEG C, stirs, in suction vacuum emulsifying machine；
(3) start is uniformly mixed, 30 minutes, 1000rpm/ point, stops stirring, is cooled to 40 DEG C；Add water, glycerol, 1, 2- hexanediol, 1,2- pentanediols, beta glucan, arginine, 1,3 butylene glycol, hydrolyzed vegetable protein, adenosine triphosphate, chrondroitin Sodium sulfate, artemia extract, Tremella extract, platinum powder, sodium citrate, fragrant citrus berry extract, Glycyrrhiza glabra L. root extract, Fructus Citri Limoniae Acid, denatonium benzoate, continue to stir, are cooled to room temperature；Fill, obtains final product.
CN201510829840.3A 2015-11-24 2015-11-24 Clear Virgin's milk liquid of a kind of Shu Run and preparation method thereof Active CN105596273B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510829840.3A CN105596273B (en) 2015-11-24 2015-11-24 Clear Virgin's milk liquid of a kind of Shu Run and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510829840.3A CN105596273B (en) 2015-11-24 2015-11-24 Clear Virgin's milk liquid of a kind of Shu Run and preparation method thereof

Publications (2)

Publication Number Publication Date
CN105596273A CN105596273A (en) 2016-05-25
CN105596273B true CN105596273B (en) 2017-03-29

Family

ID=55977011

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201510829840.3A Active CN105596273B (en) 2015-11-24 2015-11-24 Clear Virgin's milk liquid of a kind of Shu Run and preparation method thereof

Country Status (1)

Country Link
CN (1) CN105596273B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107550745A (en) * 2017-08-31 2018-01-09 北京明弘科贸有限责任公司 A kind of anticorrosive composite and its application
CN108272644A (en) * 2018-03-05 2018-07-13 广州市白云采妮化妆品厂 A kind of microemulsion and preparation method thereof helping active matter uniformly penetrating
CN108743504A (en) * 2018-07-26 2018-11-06 湖南慕她生物科技发展有限公司 A kind of plant acid whitening freckle-removing cream and its production technology
CN111773151B (en) * 2020-07-06 2023-01-10 广东职业技术学院 Whitening and freckle-removing antioxidant emulsion and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102406581A (en) * 2011-11-28 2012-04-11 天津郁美净集团有限公司 Skin protecting composite with function of tightening skin
CN104688666A (en) * 2015-03-13 2015-06-10 石桂源 Skin tendering regenerating mask with cordyceps sinensis and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102406581A (en) * 2011-11-28 2012-04-11 天津郁美净集团有限公司 Skin protecting composite with function of tightening skin
CN104688666A (en) * 2015-03-13 2015-06-10 石桂源 Skin tendering regenerating mask with cordyceps sinensis and preparation method thereof

Also Published As

Publication number Publication date
CN105596273A (en) 2016-05-25

Similar Documents

Publication Publication Date Title
CN103284940B (en) Saccharomycetes fermented traditional Chinese medicine composition, as well as preparation method and application thereof
CN110731922B (en) Enhanced hair loss prevention and hair growth promoting composition
CN105395458B (en) Herbal composition and application thereof
WO2015135313A1 (en) Borojo skin care product and use thereof for natural moisturizing, anti-ageing, anti-uv, anti-anaphylaxis and whitening
CN105596273B (en) Clear Virgin&#39;s milk liquid of a kind of Shu Run and preparation method thereof
CN109453087B (en) Whitening skin-penetrating lotion, preparation method thereof and whitening cosmetic additive
WO2021031750A1 (en) Mixed birch sap and application thereof in skin care cosmetic composition
CN103520081A (en) External skin care product capable of adjusting skin immunity and delaying skin aging
CN105381007B (en) External medicine composition, preparation with white-skinned face function and its preparation method and application
CN103565730A (en) Scented tea whitening skin-moistening cream and preparation method thereof
CN106132390A (en) The Melanin inhibitor being made up of D pantothenylol and the skin-lightening cosmetic containing this Melanin inhibitor
CN104027293A (en) Whitening cosmetic and preparation method thereof
CN104013560B (en) A kind of whitening Chinese medicament compositions and the application in cosmetics thereof
CN109528603A (en) Lightening compositions, whitening brightening cream comprising lightening compositions and preparation method thereof
CN103025307B (en) Chicoric acid and derivant are used for the purposes for adjusting cutaneous pigmentation
CN101849899A (en) Chinese medicinal compound extract and cosmetics comprising same as active ingredient
CN109330954B (en) Whitening skin brightening lotion, preparation method thereof and tyrosinase inhibitor
CN109276529A (en) A kind of lightening compositions and the whitening lotion comprising the composition
CN109833221A (en) A kind of anti-ageing aging facial treatment milk of eye and preparation method thereof
CN109260067A (en) A kind of myogenic honey of the ferment filtrate containing Ganoderma Sinense and preparation method thereof
CN104435630A (en) Traditional Chinese medicine composition with whitening and anti-aging effects and preparation method and application of extract thereof
CN110433122A (en) A kind of composition and its application in the skin care item for preparing light speckles, beautification and white
CN106474016A (en) A kind of scalp topical composition and scalp tonic liquid
CN105326779B (en) A kind of whitening curry and preparation method thereof
CN108670933A (en) Have both moisturizing, the skin care compositions of whitening and anti-aging and its application

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CP01 Change in the name or title of a patent holder
CP01 Change in the name or title of a patent holder

Address after: Panyu District Hualong Town Guangzhou city Guangdong province 511434 Liu Wai Street No. 13 (No. 1 building)

Patentee after: Hua An Tang biotech Group Co., Ltd.

Address before: Panyu District Hualong Town Guangzhou city Guangdong province 511434 Liu Wai Street No. 13 (No. 1 building)

Patentee before: City flower An Tang bio tech ltd, Guangzhou