CN104435630A - Traditional Chinese medicine composition with whitening and anti-aging effects and preparation method and application of extract thereof - Google Patents
Traditional Chinese medicine composition with whitening and anti-aging effects and preparation method and application of extract thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition with whitening and anti-aging effects and a preparation method and application of an extract thereof. The traditional Chinese medicine composition disclosed by the invention is prepared from the following ingredients in percentage by weight: 1-30% of radix asparagi, 1-30% of evening primrose, 3-50% of chaenomeles lagenaria, 3-50% of pomegranate peel, 1-30% of giant knotweed rhizome, 3-40% of herba selaginellae, 2-30% of cynomorium songaricum and 2-40% of oldenlandia diffusa. The extract of the traditional Chinese medicine composition disclosed by the invention plays roles in inhibiting melanocytes, inhibiting tyrosinase and resisting free radicals and ultraviolet rays, can be used for effectively inhibiting the generation of skin melanin, and has excellent whitening and anti-aging effects. The composition does not contain chemically-synthesized substances, is free from toxic or side effects, is low in skin irritation and stable in nature, and is safe and reliable.
Description
Technical field
The present invention relates to a kind of composite Chinese medicine composition, the extract of this Chinese medicine composition has whitening anti-aging effect, can be applied in skin-whitening anti-aging cosmetics, belong to field of fine chemical.
Background technology
Skin-whitening and defying age are the themes of cosmetics, and the cosmetics with skin-whitening and anti-senescence function are one of best-selling cosmetics.Modern scientific research proves, skin aging is a very complicated process, is subject to the impact of many factors, and wherein melanic generation and free radical cause the degeneration of elastic fibers of skin to be two large principal elements.Melanic forming process is: the tyrosine in human body skin melanocyte is oxidized generation DOPA and DOPA quinone under the catalytic action of tryrosinase, dopachrome, 5 is generated through resetting laggard oxidation step, 6-dihydroxy indole, istain, final synthesis of melanin.
The principal element affecting melanic formation has: the quantity of melanocyte, the activity of tryrosinase, the content of oxygen-derived free radicals and the content of tyrosine.Wherein, tyrosine is the aminoacid of needed by human, and its content is controlled by human body self.So, melanic formation be controlled, can only by controlling the content of the quantity of melanocyte, the activity of tryrosinase and oxygen-derived free radicals.So from the angle of safety, the approach of skin-whitening and skin nursing mainly contains the following aspects: one is by suppressing dermal melanin cell proliferation, reduces the quantity that melanocyte generates; Two is the catalytic activitys by the key enzyme-tryrosinase suppressing dermal melanin to generate, thus reduces melanic generating rate to reach whitening object; Three is by sun-proof, prevents sunlight middle-ultraviolet lamp to the injury (tanned and sunburn) of skin, slows down skin aging; Four is the oxygen-derived free radicals by using in antioxidant removal skin, slows down melanin and generates and delay skin aging.
Free radical is the key factor causing skin aging, and air pollution, pressure, medicine etc. all can make health produce free radical, and ultraviolet is the major inducing factor of skin free radical.Free radical contains the molecule of one or more unpaired electron or a part for molecule, has the tendency of pairing.Therefore most of free radical is all very active, has the chemism of height.Under normal circumstances, the free radical in human body is among the continuous dynamic equilibrium produced and remove.But free radical produces too much or removed slow, and it, by attacking life macromolecule material and various cell, can cause the various damages of body, accelerates the senescence process of body, shows change old and feeble gradually, as age pigment deposit, skin is wrinkling.Therefore, while whitening, strengthen free radical resisting extremely important.
At present, all there is larger defect in the management of China's skin-lightening cosmetic and technology, the phenomenon of adding in violation of rules and regulations is very serious, what have even bleaches using contrabands such as aminomercuric chlorides as peroxide such as whitening agent or interpolation hydrogen peroxide, cause many beauty treatment accidents for many years, even disfeature, cause very large injury to consumer, caused the great attention of country and consumer.In recent years, the whitening agent used in cosmetics mainly contains the compounds such as hydroquinone (hydroquinone), L-AA (vitamin C), kojic acid, superoxide dismutase (SOD) and arbutin.But these whitening agents also exist many defects, the zest as hydroquinone is very large, and vitamin C and SOD are very unstable, and kojic acid also has certain zest and sex chromosome mosaicism easy to change, the single and poor effect of arbutin effect etc.So exploitation has good safety, stability, inhibition is obvious, and the natural whiting agent that cost performance is good, has become one of main direction of studying of current medicine and cosmetic industry, had extraordinary development prospect.Natural materials is applied to cosmetics can reach skin treating and defying age double effects, and has diverse in function, the characteristic such as widely applicable, safe, thus day by day comes into one's own.As patent of invention CN102225039A discloses a kind of whitening Chinese medicament compositions containing Radix Glycyrrhizae, Cortex Moutan, Fructus Atriplicis Sibiricae, Rhizoma Polygonati, Herba Leonuri, this Chinese medicine composition adopts decocting method to carry out extraction preparation.Patent of invention CN101612105 disclose a kind of by the Pseudobulbus Bletillae (Rhizoma Bletillae), hold back in vain, Cortex Mori, Poria, Fructus Atriplicis Sibiricae, the Rhizoma Atractylodis Macrocephalae, Fructus Amomi Rotundus, the Radix Paeoniae Alba, Herba Pyrolae and Radix Angelicae Sinensis the whitening anti-aging Chinese medicine composition that forms of extract and preparation method thereof, said composition adopts the method preparation of soak extraction and anion exchange resin separation and concentration.Patent of invention CN101732223A disclose a kind of by Aloe, Faeces Passeris, lead a cow in vain, pure Chinese medicine whitening anti-aging liquid that Poria, Semen Ginkgo core, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae, the Rhizoma Atractylodis Macrocephalae, Nidus collocaliae, Semen Coicis, Radix Gentianae, Radix Angelicae Sinensis, Semen Ginkgo form, this Chinese medicine composition adopts decocting method to carry out extractions to prepare.Patent of invention CN101804185A discloses a kind of freckle removal traditional Chinese medicinal composition containing Radix Bupleuri, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Fructus Corni, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Chuanxiong, Semen Persicae, Bombyx Batryticatus, Roast Rhizoma Zingiberis Recens, Herba Menthae and Radix Glycyrrhizae Preparata, and this Chinese medicine composition have employed and adopts carbon dioxide supercritical fluid extraction technology to extract.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition, the extract energy restraint of tyrosinase activity of this Chinese medicine composition, check melanin cytoactive, absorb the effect of ultraviolet and scavenging free radicals, there is skin-whitening and antidotal function, and there is the advantages such as stable in properties, zest be little.
To achieve the object of the present invention, present invention employs following technical scheme:
There is a Chinese medicine composition for whitening anti-aging function, it is characterized in that the component comprising following percentage by weight:
The extract of above-mentioned Chinese medicine composition adopts following preparation method to obtain: the Radix Asparagi in above-mentioned Chinese medicine composition, Radix Oenotherae erythrosepalae, Fructus Chaenomelis, Pericarpium Granati, Rhizoma Polygoni Cuspidati, Herba Selaginellae, Herba Cynomorii, Herba Hedyotidis Diffusae are pulverized, mix homogeneously after sieving, add Extraction solvent, heating and refluxing extraction 1 ~ 3 time, merge extractive liquid, with activated carbon decolorizing, filtration, filtrate, through being evaporated to extractum shape, to obtain final product.Described Extraction solvent is water, ethanol, ethanol water.
Another object of the present invention is used in skin-whitening and anti-aging cosmetics by the extract of this Chinese medicine composition, makes stable in properties, respond well whitening anti-aging cosmetics.
The application of extract in preparation whitening anti-aging cosmetics of above-mentioned Chinese medicine composition, it is characterized in that the extract containing above-mentioned Chinese medicine composition in whitening anti-aging cosmetics, its consumption is 0.05 ~ 20%, and preferable amount is 0.5 ~ 10%.Except containing except above-mentioned Chinese medicine composition, the usual composition that applicable cosmetics use suitably can be added as required, as matrix components such as wetting agent, emollient, water, emulsifying agents.
The dosage form of whitening anti-aging cosmetics is not particularly limited, and can be solution, emulsion, paste, powdery, spray etc.
Beneficial effect of the present invention: the extract of Chinese medicine composition of the present invention has check melanin cell, restraint of tyrosinase, free radical resisting and uvioresistant effect, can effectively suppress dermal melanin to generate, has excellent whitening and anti-aging effects.Said composition is not containing the material of chemosynthesis, and have no side effect, skin irritation is little, and stable in properties is safe and reliable.In addition, except whitening effect, because said composition contains plurality of Chinese active component, have the function of activating blood circulation to dissipate blood stasis, can be skin directly provides and nourishes the nutrition composition in its normal physiological processes, promotes skin metabolism, improve the health of skin, there is good skin effect.
Detailed description of the invention
Below by way of specific embodiment, the present invention is further illustrated, but these embodiments are just in order to illustrate, are not limitations of the present invention.
The preparation of embodiment 1 Chinese medicine composition (I) and extract thereof
Get Radix Asparagi, Radix Oenotherae erythrosepalae, Fructus Chaenomelis, Pericarpium Granati, Rhizoma Polygoni Cuspidati, Herba Selaginellae, Herba Cynomorii, each 100g of Herba Hedyotidis Diffusae, pulverize, cross mix homogeneously after 40 mesh sieves, add the ethanol water 6.4kg that mass fraction is 95%, heating and refluxing extraction 60min, repeat extraction 3 times, merge extractive liquid, with activated carbon decolorizing, filtration, filtrate, through being evaporated to extractum shape, to obtain final product.
The preparation of embodiment 2 Chinese medicine composition (II) and extract thereof
Get Radix Asparagi 50g, Radix Oenotherae erythrosepalae 80g, Fructus Chaenomelis 100g, Pericarpium Granati 150g, Rhizoma Polygoni Cuspidati 70g, Herba Selaginellae 60g, Herba Cynomorii 90g, Herba Hedyotidis Diffusae 150g, pulverize, cross mix homogeneously after 40 mesh sieves, add the ethanol water 7.5kg that mass fraction is 70%, heating and refluxing extraction 90min, repeat extraction 2 times, merge extractive liquid, with activated carbon decolorizing, filtration, filtrate, through being evaporated to extractum shape, to obtain final product.
The preparation of embodiment 3 Chinese medicine composition (III) and extract thereof
Get Radix Asparagi 60g, Radix Oenotherae erythrosepalae 100g, Fructus Chaenomelis 60g, Pericarpium Granati 120g, Rhizoma Polygoni Cuspidati 90g, Herba Selaginellae 80g, Herba Cynomorii 100g, Herba Hedyotidis Diffusae 90g, pulverize, cross mix homogeneously after 40 mesh sieves, add the ethanol water 7kg that mass fraction is 50%, heating and refluxing extraction 60min, repeat extraction 3 times, merge extractive liquid, with activated carbon decolorizing, filtration, filtrate, through being evaporated to extractum shape, to obtain final product.
Embodiment 4 whitening anti-aging effect assessment experimental technique and result
1, the preparation of sample
The extract of above-described embodiment Chinese medicine composition is dissolved in dimethyl sulfoxine, is made into the sample solution that concentration is 0.1%, test below carrying out.Simultaneously with arbutin sample in contrast.
2, restraint of tyrosinase vigor effect assessment test
By table 1 accurately pipette samples solution, pH value be 6.8 phosphate buffered solution (PBS) and mass fraction be 0.1% DOPA solution, abundant mixing, after hatching 5min in 30 DEG C, add the tyrosinase solution that activity is 110U/mL, 10min is hatched again at 30 DEG C, be transferred to rapidly in cuvette, survey absorbance at 475nm place.Use kojic acid, hydroquinone, ascorbic acid, arbutin thing in contrast.
Table 1
By the relative inhibition (I, be called for short suppression ratio, lower same) of formula (1) calculation sample to tryrosinase.
In formula: A
1, A
2, A
3, A
4be respectively the absorbance of 1 group ~ 4 groups of solution.
3, B16 cell test in check melanin cell
By B16 melanoma cell with 1 × 10
5the density of individual/mL is inoculated in 96 orifice plates, every hole 90 μ L, CO
2after hatching 24 hours in incubator, every hole adds sample solution.Set up the blank group of culture medium and cell simultaneously.
Be placed in by culture plate after incubator hatches 72 hours, abandoning supernatant, PBS washing twice, then every hole adds 0.5mL trypsin digestion cell 3min, and every hole adds 2mL maintenance medium and stops digestion.After mixing, often kind of concentration is taken out 0.5mL and is made cell counting.All the other cell suspension are with 2500r/min centrifugalize 5min, and abandoning supernatant, adds NaOH solution in precipitation, and heating makes melanin dissolve, and select 490nm wavelength to measure absorbance under enzyme-linked immunosorbent assay instrument.By formula (2) calculation sample to B16 cell suppression ratio (I ').
In formula: A
5for medicine hole absorbance; P
1for medicine porocyte density; A
6for control wells absorbance; P
2for control wells cell density.
4, Hydroxyl radical-scavenging effect assessment test
2mmol/L FeSO is added successively in 25mL color comparison tube
43mL, 1mmol/L H
2o
23mL, shakes up, and then adds 6mmol/L salicylic acid 3mL, shakes up, take out after 37 DEG C of heating in water bath 15min, survey its absorbance A
o.Then add certain density analyte sample fluid 0.2mL, 0.4mL, 0.6mL, 0.8mL, 1.0mL respectively, and then add distilled water 0.8mL, 0.6mL, 0.4mL, 0.2mL, 0mL respectively, shake up, continue heating in water bath 15min, take out and survey its absorbance A
x.As stated above, add each liquid as shown in table 2, do not add salicylic acid, shake up, heating in water bath 15min, measured value A
xo.
Table 2
Free radical scavenging activity (D) is calculated by formula (3).
The free clearance rate of hydroxyl (%)=A
o-(A
x-A
xo)/A
o* 100 (3)
A in formula
ofor the light absorption value of blank; A
xfor adding the light absorption value of sample; A
xofor not adding developer H
2o
2solution background absorption value
5, uvioresistant effect assessment test
Test according to People's Republic of China (PRC) light industry standard QB/T2334-1997 (cosmetics middle-ultraviolet lamp absorbent qualitative determination-ultraviolet spectrophotometry).By sample solution with 95% ethanol dilution to 100mL, then within the scope of 280 ~ 400nm, scan every 10nm, determine the absorbance under each wavelength, and calculate mean light absorbency.
6, experimental result
The experiment of whitening anti-aging effect assessment is shown in Table 3.
Table 3
Experimental result shows, the extract of Chinese medicine composition of the present invention can restraint of tyrosinase activity and check melanin synthesize effectively, and have scavenging free radicals and anti-ultraviolet function, these functions are all better than whitening agent---arbutin conventional at present simultaneously.
The preparation of embodiment 5 whitening anti-aging breast
Table 4 provides the whitening anti-aging breast formula of the extract containing Chinese medicine composition, and the consumption of each material represents with mass fraction.
Table 4
The preparation method of whitening anti-aging breast: each for component A material (extract except Chinese medicine composition) is added to the water, is heated to 85 DEG C and makes it dissolve, obtained aqueous phase.Separately B component is mixed post-heating to 85 DEG C melting, add component C before emulsifying, dispersed with stirring is obtained oil phase evenly.B component and component C are slowly added in component A under stirring, homogenizing process, adds extract and the D component of Chinese medicine composition in time being cooled to 50 DEG C, continues slowly to stir, and is cooled to room temperature, can packs after ageing 24h.
The preparation of embodiment 6 whitening anti-aging elite dew
Table 5 provides the whitening anti-aging elite dew formula containing Chinese medicine composition, and the consumption of each material represents with mass fraction.
Table 5
The preparation method of whitening anti-aging elite dew: deionized water is heated to 85 DEG C, adds hydroxyethyl-cellulose, stirring and dissolving is even, adds 1,3 butylene glycol.When stirring is cooled to 50 DEG C, add other compositions, continue to stir, be cooled to 38 DEG C, be whitening anti-aging elite dew.
Claims (2)
1. one kind has the Chinese medicine composition of whitening anti-aging effect, it is characterized in that by weight percentage, composed of the following components: Radix Asparagi 1 ~ 30%, Radix Oenotherae erythrosepalae 1 ~ 30%, Fructus Chaenomelis 3 ~ 50%, Pericarpium Granati 3 ~ 50%, Rhizoma Polygoni Cuspidati 1 ~ 30%, Herba Selaginellae 3 ~ 40%, Herba Cynomorii 2 ~ 30%, Herba Hedyotidis Diffusae 2 ~ 40%; The extract of above-mentioned Chinese medicine composition adopts following preparation method to obtain: the Radix Asparagi in above-mentioned Chinese medicine composition, Radix Oenotherae erythrosepalae, Fructus Chaenomelis, Pericarpium Granati, Rhizoma Polygoni Cuspidati, Herba Selaginellae, Herba Cynomorii, Herba Hedyotidis Diffusae are pulverized, mix homogeneously after sieving, add Extraction solvent, heating and refluxing extraction 1 ~ 3 time, merge extractive liquid, with activated carbon decolorizing, filtration, filtrate, through being evaporated to extractum shape, to obtain final product; Described Extraction solvent is water, ethanol, ethanol water.
2. the whitening anti-aging cosmetics of the extract containing Chinese medicine composition described in claim 1, it is characterized in that: the extract containing Chinese medicine composition according to claim 1 in these whitening anti-aging cosmetics, its consumption is 0.05-20%, and preferable amount is 0.5 ~ 10%.
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Cited By (8)
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| CN107375186A (en) * | 2017-09-04 | 2017-11-24 | 山东美貌化妆品股份有限公司 | A kind of skin care item containing compound fruit extract and preparation method thereof |
| CN109330917A (en) * | 2018-11-15 | 2019-02-15 | 广东轻工职业技术学院 | A kind of essential oil composition having both whitening anti-aging moisture-keeping efficacy and application |
| CN110236997A (en) * | 2019-06-20 | 2019-09-17 | 佛山市普达美生物医药科技有限公司 | A kind of composition and preparation method thereof with whitening function |
| CN112494414A (en) * | 2020-12-21 | 2021-03-16 | 现代百朗德生物科技(江苏)有限公司 | Traditional Chinese medicine compound with whitening and anti-aging effects and preparation method thereof |
| CN113143824A (en) * | 2021-05-07 | 2021-07-23 | 广州易和生物科技有限公司 | Composition with whitening effect and preparation method thereof |
| CN114209641A (en) * | 2021-12-23 | 2022-03-22 | 广州远想生物科技股份有限公司 | Plant compound composition for fading pigments and preparation method thereof |
| CN116509773A (en) * | 2023-06-15 | 2023-08-01 | 广州若诗生物科技有限公司 | Composition with multiple skin care effects and application thereof |
| CN117547497A (en) * | 2023-12-31 | 2024-02-13 | 武汉森澜生物科技有限公司 | Whitening and anti-aging composition for inhibiting tyrosinase activity and application thereof |
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| CN107375186A (en) * | 2017-09-04 | 2017-11-24 | 山东美貌化妆品股份有限公司 | A kind of skin care item containing compound fruit extract and preparation method thereof |
| CN109330917A (en) * | 2018-11-15 | 2019-02-15 | 广东轻工职业技术学院 | A kind of essential oil composition having both whitening anti-aging moisture-keeping efficacy and application |
| CN109330917B (en) * | 2018-11-15 | 2021-06-01 | 广州天芝丽实业有限公司 | Essential oil composition with whitening, anti-aging and moisturizing effects and application thereof |
| CN110236997A (en) * | 2019-06-20 | 2019-09-17 | 佛山市普达美生物医药科技有限公司 | A kind of composition and preparation method thereof with whitening function |
| CN110236997B (en) * | 2019-06-20 | 2022-06-21 | 佛山市普达美生物医药科技有限公司 | Composition with whitening effect and preparation method thereof |
| CN112494414B (en) * | 2020-12-21 | 2022-11-15 | 现代百朗德生物科技(江苏)有限公司 | Traditional Chinese medicine compound with whitening and anti-aging effects and preparation method thereof |
| CN112494414A (en) * | 2020-12-21 | 2021-03-16 | 现代百朗德生物科技(江苏)有限公司 | Traditional Chinese medicine compound with whitening and anti-aging effects and preparation method thereof |
| CN113143824A (en) * | 2021-05-07 | 2021-07-23 | 广州易和生物科技有限公司 | Composition with whitening effect and preparation method thereof |
| CN114209641A (en) * | 2021-12-23 | 2022-03-22 | 广州远想生物科技股份有限公司 | Plant compound composition for fading pigments and preparation method thereof |
| CN114209641B (en) * | 2021-12-23 | 2023-05-12 | 广州远想生物科技股份有限公司 | Plant compound composition for fading pigment and preparation method thereof |
| CN116509773A (en) * | 2023-06-15 | 2023-08-01 | 广州若诗生物科技有限公司 | Composition with multiple skin care effects and application thereof |
| CN116509773B (en) * | 2023-06-15 | 2024-06-07 | 广州若诗生物科技有限公司 | Composition with multiple skin care effects and application thereof |
| CN117547497A (en) * | 2023-12-31 | 2024-02-13 | 武汉森澜生物科技有限公司 | Whitening and anti-aging composition for inhibiting tyrosinase activity and application thereof |
| CN117547497B (en) * | 2023-12-31 | 2024-04-09 | 武汉森澜生物科技有限公司 | Whitening and anti-aging composition for inhibiting tyrosinase activity and application thereof |
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Effective date of registration: 20190409 Address after: 510670 Building 502, G11, 31 Kefeng Road, Luogang District, Guangzhou City, Guangdong Province Co-patentee after: Guangzhou Zhihui Biotechnology Co., Ltd. Patentee after: Guangzhou Huibiao Testing Technology Center Address before: 510663 Building 502, G11, 31 Kefeng Road, Luogang District, Guangzhou City, Guangdong Province Patentee before: Guangzhou Huibiao Testing Technology Center |
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