CN110151572A - A kind of Chinese medicine compound prescription extraction composition and its application in cosmetics - Google Patents
A kind of Chinese medicine compound prescription extraction composition and its application in cosmetics Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine compound prescriptions to extract composition and its application in cosmetics, component including following parts by weight: 2~10 parts of Salvia root P.E, 2~10 parts of Rhizoma Chuanxiong extract, 2~10 parts of angelica extract, 2~10 parts of radix paeoniae alba extraction, 2~10 parts of ginseng extract, 1~10 part of beta glucan, 2~5 parts of vitamin B5, 2~5 parts of glycine betaine, Cer NS~5 part, 0.1~5 part of compound essential oil, fuller olefinic carbon 60 .1~3 part, 0.1~2 part of tetrahydro methylpyrimidine carboxylic acid, 0.1~1 part of bisabolol, 0.1~0.3 part of xanthan gum, 0.01~0.1 part of macromolecular hyaluronic acid, 0.01~0.1 part of micromolecule hyaluronic acid, it can be applied to facial cleanser, shower cream, lotion, frost, in the cosmetics such as Essence and facial mask , there is anti-aging, desalination microgroove, light spot, moisturizing, moisturizing, repair the multiple efficacies such as stratum corneum barrier function is impaired.
Description
Technical field
The invention belongs to Chinese medicine and cosmetic technical fields.Specifically, be a kind of Chinese medicine compound prescription extract composition and its
Application in cosmetics.
Background technique
Currently on the market and has no lack of all kinds of skin-protection products and remove the operation on skin such as wrinkle, laser therapy, but for
Most of general populations often carry out skin care without the time, and existing since operating pressure is big, rhythm of life is fast
Anti-aging product quality it is irregular, adverse reaction is commonplace so that have source is natural, adverse reaction is small and has
Chinese herbal medicine with a long history at beautifying and anti-aging field new lover.Traditional Chinese medicine possesses long history in China, in clinic
It is upper very widely used, but only seldom advocate natural cosmetics brand at present and be related to using Chinese medical extract, traditional Chinese medicine is precious
Library is not fully developed.It is especially not high with the Chinese medical extracts availability such as Radix Salviae Miltiorrhizae, Radix Paeoniae Alba.Market is with more typical anti-ageing ingredient
Retinol etc., but due to certain irritation and toxic side effect, it can be effective using the addition of natural Chinese traditional medicines ingredient
Solve the problems, such as this.
For the anti-aging cosmetics of traditional Chinese medicine ingredients, existing patent document CN105326780A(anti aging effect
Cosmetic and preparation method thereof, 2016.02.17) it discloses by dendrobium candidum, Radix Paeoniae Alba, the bletilla striata, ginkgo, Poria cocos, Rhizoma Chuanxiong, dried orange peel, pellet
Ginseng, Radix Curcumae, Caulis Spatholobi, Schisandra chinensis, purple perilla, Semen Cuscutae etc. are through having the change of anti-senescence function prepared by decoction, filtering, concentration
Cosmetic.And a kind of pure natural promoting blood circulation ageing-resistant skin care composition of existing patent document CN106473980A(and its in cosmetics
In application, 2017.03.08) it is disclosed with resveratrol, maritime pine bark/bud extract, borneol, Sodium Hyaluronate, thorn five
Add extract, coconut oil PEG-10 lipid, walnut oil, curcumin, angelica extract, Folium Artemisiae Argyi extract, lamp stand tree extractive,
The cosmetics that ivy extract, salvia miltiorrhiza flower/leaf/root extract and Cortex Magnoliae Officinalis tree extract are used as additive, the cosmetics
It is effective against free radical, delay skin aging and the microcirculation for improving skin tissue.
For above-mentioned anti-aging cosmetics, the traditional Chinese medicine ingredients used avoid the chemistry of irritation and toxic side effect
The addition of synthetic such as retinol, improves the security performance of cosmetics, however as people to cosmetic industry demand not
It is disconnected to increase, for the cosmetics for being only limitted to senile-resistant efficacy, have been unable to meet current increasingly diversified market development.?
Studies have found that specific effect is played to skin although can incorporate in skin care item by the extract of raw material of Chinese herbal medicine,
But since Chinese herbal medicine extract component is complicated, mechanism of action multiplicity exists simultaneously extensive interaction, therefore, has to realize
The cosmetics of comprehensive Chinese medicine value, not only need with traditional theory of traditional Chinese medical science, it is also necessary to right in conjunction with modern science and technology
Its further investigation can just obtain.
Summary of the invention
The purpose of the present invention is to provide a kind of Chinese medicine compound prescriptions to extract composition and its application in cosmetics, by having
The Chinese medical extract of medicinal herb components and other Multifunctional matters are used in compounding to form Chinese medicinal compound extract, can be applied to wash one's face
In the cosmetics such as milk, shower cream, lotion, frost, Essence and facial mask, there is anti-aging, desalination microgroove, light spot, moisturizing, guarantor
It is wet, repair the multiple efficacies such as stratum corneum barrier function is impaired.
The present invention is achieved through the following technical solutions: a kind of Chinese medicine compound prescription extraction composition, including following parts by weight
Component: 2~10 parts of Salvia root P.E, 2~10 parts of Rhizoma Chuanxiong extract, 2~10 parts of angelica extract, 2~10 parts of radix paeoniae alba extraction,
2~10 parts of ginseng extract, 1~10 part of beta glucan, 2~5 parts of vitamin B5,2~5 parts of glycine betaine, Cer NS~5
Part, 0.1~5 part of compound essential oil, fuller olefinic carbon 60 .1~3 part, 0.1~2 part of tetrahydro methylpyrimidine carboxylic acid, 0.1~1 part of bisabolol,
0.1~0.3 part of xanthan gum, 0.01~0.1 part of macromolecular hyaluronic acid, 0.01~0.1 part of micromolecule hyaluronic acid.
Wherein, Salvia root P.E be using Lamiaceae plant Radix Salviae Miltiorrhizae as raw material, after extraction separation and purification, acquisition containing plant it is more
The solution of kind effective component, mainly based on tanshinone IIA, tanshinone ⅡB, Cryptotanshinone.
Rhizoma Chuanxiong extract is using umbelliferae Rhizoma Chuanxiong as raw material, and after extraction separation and purification, acquisition has containing plant is a variety of
The solution for imitating ingredient, mainly based on ligustrazine, ferulic acid.
Angelica extract is using umbelliferae angelica as raw material, and after extraction separation and purification, acquisition has containing plant is a variety of
The solution for imitating ingredient, mainly based on river volatile oil, sucrose, vitamin B12 and retinoid substance.
Radix paeoniae alba extraction is using ranunculaceae plant Radix Paeoniae Alba as raw material, after extraction separation and purification, the ingredient containing mass efficient of acquisition
Powder, mainly based on Paeoniflorin.
Ginseng extract is using the root of Araliaceae ginseng as raw material, after extraction separation and purification, acquisition containing plant it is a variety of
The solution of effective component, mainly with ginsenoside, volatile oil, amino acid, peptides, glucose, vitamin B1, B2, niacin, pantothenic acid
Based on.
Beta glucan is a kind of non-starch polysaccharide for being present in oat endosperm and gluten cell wall, and by monomer pyrans
Glucose, got up a kind of high molecular polymer to be formed by glucosides key connection, and has unique straight-chain molecular structure, is had
Long-acting moisturizing, the wrinkle resistant effect of antiallergic.
Vitamin B5 is a kind of wetting agent of good good penetrability, is widely used in all kinds of skin care item at present.
Glycine betaine is a spin-off of amino acid, and content is higher in plant or shellfish biology, is being used for cosmetics
When, it can be reduced the viscous glutinous sense of glycerol in skin-protection product, can also have the function of stable foam in cleaning products.
Ceramide is to extract to obtain from the good quality wheat containing abundant ceramide, is a kind of comprehensive anti-aging
Agent.
The compound essential oil that olibanum, myrrh, santal are extracted can be used in compound essential oil, have it is anti-ageing, go wrinkle, light spot, guarantor
Wet, moist effect.
Fullerene is known anti-ageing ingredient, and oxidation resistance is ascorbic 125 times.Scientific investigations showed that fowler
Alkene can act on skin ageing source, resist ultraviolet light, and repair damage, prevent wrinkle from generating, and the solution colour of skin is low and deep, and pore is thick
The aging phenomena such as big.
Tetrahydro methylpyrimidine carboxylic acid is a kind of resistance to compression that effect is distinguished protection molecule, and a kind of multi-functional activity at
Point, having prevents cell light aging, long-acting moisturizing, improves wrinkle, repairs and make aging or impaired skin regeneration.
Bisabolol is the active skull cap components extracted from chamomile (chamomile), and having reduces product stimulation, is improved
The anti-irritant ability of skin, the effect repaired impaired skin, mitigate acne, can be used for various skin-protection products, sun-proof production
Product, child care products, whitening product, anti-aging product, anti-acne product etc..
Xanthan gum has the polyol of more side chain linear structures, and hydroxyl can combine with hydrone, formed compared with
Stable reticular structure, and viscosity with higher at very low concentrations, thickening effect is significant, therefore, also has and protrudes
High viscosity and water solubility, in this application, xanthan gum is used as efficient emulsion stabilizer.
Macromolecular hyaluronic acid be made of the disaccharide repetitive unit of N-acetylglucosamine and glucuronic acid it is viscous
Polysaccharose substance, molecular weight are 100 ten thousand to 170 ten thousand, are widely present in animal tissue cell's interstitial and vitreum.
The molecular weight of micromolecule hyaluronic acid is 280,000 to 800,000, and when being used cooperatively with other components, small molecule is transparent
Matter acid is permeable to skin corium, promotes blood circulation, and improves absorption of the skin to nutriment, absorb molecular weight 1,000,000 with
Under.
Further, 2 parts of Salvia root P.E, 2 parts of Rhizoma Chuanxiong extract, 2 parts of angelica extract, 2 parts of radix paeoniae alba extraction, ginseng
2 parts of extract, 8 parts of beta glucan, 1 part of vitamin B5,1 part of glycine betaine, Cer NS part, 1 part of compound essential oil, fullerene 1
Part, 0.3 part of tetrahydro methylpyrimidine carboxylic acid, 0.5 part of bisabolol, 0.1 part of xanthan gum, 0.05 part, small point of macromolecular hyaluronic acid
0.05 part of sub- hyaluronic acid.
A kind of Chinese medicine compound prescription extracts application of the composition in cosmetics, and Chinese medicine compound prescription extraction composition is applied to
In facial cleanser, shower cream, lotion, frost, Essence and facial mask.
Compared with prior art, the present invention have the following advantages that and the utility model has the advantages that
(1) it is formed involved in the present composition by being matched in proportion by traditional Chinese medicine ingredients Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Radix Paeoniae Alba, ginseng
Compound extract is applied in cosmetics, avoids using chemical industry synthesis substance, mild non-stimulated outer, also have moisturizing, brilliant white,
Sterilization, moisturizing, anti-aging, smooth, tender and other effects.
(2) to guarantee that the compound extract of traditional Chinese medicine ingredients is preferably applied in cosmetics, and skin is promoted to absorb, passed through
By the compound extract of traditional Chinese medicine ingredients, with beta glucan, vitamin, glycine betaine, ceramide, compound essential oil, fullerene, tetrahydro
The multifunctional agents such as methylpyrimidine carboxylic acid, bisabolol, xanthan gum, macromolecular hyaluronic acid, micromolecule hyaluronic acid compounding makes
With more stable compared with the anti-ageing effect of cosmetics of same type traditional Chinese medicine ingredients, permanence operation is best.
Specific embodiment
The present invention is described in further detail below with reference to embodiment, embodiments of the present invention are not limited thereto.
Embodiment 1:
The present embodiment is related to a kind of Chinese medicine compound prescription extraction composition.
2 parts of Salvia root P.E, 2 parts of Rhizoma Chuanxiong extract, 10 parts of angelica extract, 10 parts of radix paeoniae alba extraction, ginseng are taken respectively
10 parts of extract, 10 parts of beta glucan, 3 parts of vitamin B5,5 parts of glycine betaine, Cer NS part, 3 parts of compound essential oil, fullerene
3 parts, 2 parts of tetrahydro methylpyrimidine carboxylic acid, 1 part of bisabolol, 0.3 part of xanthan gum, 0.1 part of macromolecular hyaluronic acid, small molecule it is saturating
Bright 0.01 part of matter acid, after mixing, buff is obtained, extracts composition in the watery Chinese medicine compound prescription of stiff.
Embodiment 2:
The present embodiment is related to a kind of Chinese medicine compound prescription extraction composition.
10 parts of Salvia root P.E, 10 parts of Rhizoma Chuanxiong extract, 2 parts of angelica extract, 2 parts of radix paeoniae alba extraction, ginseng are taken respectively
2 parts of extract, 1 part of beta glucan, 5 parts of vitamin B5,2 parts of glycine betaine, 5 parts of ceramide, 5 parts of compound essential oil, fullerene
0.1 part, it is 0.1 part of tetrahydro methylpyrimidine carboxylic acid, 0.1 part of bisabolol, 0.1 part of xanthan gum, 0.01 part of macromolecular hyaluronic acid, small
0.1 part of molecular weight hyaluronic acid, after mixing, buff is obtained, extracts composition in the watery Chinese medicine compound prescription of stiff.
Embodiment 3:
The present embodiment is related to a kind of Chinese medicine compound prescription extraction composition.
2 parts of Salvia root P.E, 2 parts of Rhizoma Chuanxiong extract, 2 parts of angelica extract, 2 parts of radix paeoniae alba extraction, ginseng is taken to mention respectively
Take 2 parts of object, 8 parts of beta glucan, 1 part of vitamin B5,1 part of glycine betaine, Cer NS part, 1 part of compound essential oil, 1 part of fullerene,
0.3 part of tetrahydro methylpyrimidine carboxylic acid, 0.5 part of bisabolol, 0.1 part of xanthan gum, 0.05 part of macromolecular hyaluronic acid, small molecule are saturating
Bright 0.05 part of matter acid, after mixing, buff is obtained, extracts composition in the watery Chinese medicine compound prescription of stiff.
In the component that above-described embodiment 1-3 is related to, Salvia root P.E is the dry root and rhizome for taking Lamiaceae plant Radix Salviae Miltiorrhizae
Powder is beaten, then is obtained with propylene glycol refluxing extraction；Rhizoma Chuanxiong extract is that the dry rhizome of umbelliferae is taken to beat powder, then with the third two
Alcohol reflux extraction obtains；Angelica extract is to take the dry root of umbelliferae to beat powder, then obtained with propylene glycol refluxing extraction
It arrives；Radix paeoniae alba extraction is to take the dry root of ranunculaceae plant Chinese herbaceous peony to beat powder, then obtained with propylene glycol refluxing extraction；Ginseng extracts
Object is to take the dry root of Araliaceae ginseng to beat powder, then obtained with propylene glycol refluxing extraction；Beta glucan is purchased from Guangzhou beauty
Virtuous Biotechnology Co., Ltd, lot number MY19021504；Vitamin B5 is purchased from Guangzhou Mei Yi Biotechnology Co., Ltd, lot number
MY19030801；Glycine betaine is purchased from Guangzhou Mei Yi Biotechnology Co., Ltd, lot number MY19010204；Ceramide is purchased from Shanghai
Ao Li Chemical Industry Science Co., Ltd, lot number 2019022601；Compound essential oil is to take olive subject plant Boswellia carterii and congener tree
The resin of skin exudation, is made olibanum essential oil with the way of distillation, takes olive subject plant Chinese violet tree or the dry resin of Ha Didingshu, distills
Legal system obtains myrrh essential oil, and the heartwood of sandalwood plants santal is taken to beat powder, and the way of distillation extracts sandalwood essential oil, olibanum essential oil, myrrh essence
Oil and sandalwood essential oil mix up to compound essential oil；Fullerene is purchased from manufacturer: Mitsubishi business Co., Ltd, importer: wide
Dong Kesuo Chemical Co., Ltd., lot number 190121；Tetrahydro methylpyrimidine carboxylic acid is purchased from Shandong You Suo Chemical Industry Science Co., Ltd, batch
Number 079215009092；Bisabolol is purchased from Ke Naiou trade (Shanghai) Co., Ltd. Guangzhou Branch, lot number
S201704250241A；Xanthan gum is purchased from Shandong You Suo Chemical Industry Science Co., Ltd, lot number 079215004200；Macromolecular is transparent
Matter acid is purchased from Bloomage Freda Biopharm Co., Ltd., lot number 1812102；Micromolecule hyaluronic acid is purchased from the prosperous Fu Ruidasheng of China
Object Pharmaceuticals Ltd, lot number 1812153.
It chooses the Chinese medicine compound prescription that above-described embodiment 3 is related to and extracts the following verification test of composition progress:
(1) inhibit the measurement of tyrosinase vigor
It is loaded according to following table (table 1), tyrosinase is not added, 1% arbutin is compared into as one group of sample and is placed in solution
In 37 DEG C of water-baths after constant temperature 10min, its absorbance value is measured under 475nm, and be compared with 1% arbutin.
Table 1
| Blank control (ml) | Blank (ml) | Sample controls (ml) | Experimental group (ml) | |
| Sample | —— | —— | 1 | 1 |
| L-tyrosine | 1 | 1 | 1 | 1 |
| Tyrosinase | —— | 0.5 | —— | 0.5 |
| PBS(Ph=6.8) | 2 | 1.5 | 1 | 0.5 |
| Total amount | 3 | 3 | 3 | 3 |
Sample is calculated to the relative inhibition of tyrosinase according to formula (1).
Inhibiting rate=[(A1-A2)-(A3-A4)]/(A1-A2) formula (1)
The absorbance that A1, A2, A3, A4 are 1 group to 4 groups in formula (1).
(2) measurement of ultra-oxygen anion free radical scavenging effect
4.5 milliliters of Tris-HC1 buffer of 0.05mol/L pH=8.2 are taken, 20min is preheated in 25 DEG C of water-baths and is being added
The neck benzenetriol solution of 1mL sample and 0.4mL 25mmol/L after mixing, reacts 5min in 25 DEG C of water-baths, 8molL is added
HC11.0mL terminate reaction.Make reference with Tris-HCI buffer, absorbance value is surveyed at 299nm.Blank control is tried with 1mL
The solvent of sample substitutes sample.Clearance rate (D) is calculated according to formula (2).
Clearance rate (%)=[1-(B2/B1)] × 100%, B1 is the absorbance value of blank control in formula, and B2 is the suction of cosmetics
Shading value.
(3) Scavenging activity of hydroxy radical is measured
2mmol/L FeSO4,3mL are sequentially added in 25mL colorimetric cylinder, 1lmol/L H202mL shakes up, is subsequently added into
6mmol/L salicylic acid 3mL, shakes up, and takes out after 37 DEG C of heating water bath 15min, measures absorbance;It is separately added into certain density
Prepare liquid shakes up, and continues heating water bath 15min, takes out and measures its absorbance.Following formula (3) is prepare liquid to carboxylic free radical (OH)
Clearance rate
Clearance rate (%)=[C1-C2-(C1-C3)] formula of/C1 × 100% (3)
C1 is the absorbance value of reaction system before not adding cosmetics in formula；C2 is the absorbance value that drug removes system after OH；C3
For system absorbance value after blank control clearance rate.
Anti-senescence function evaluation experimental is as shown in table 2 below:
The experiment of 2 anti-aging result of table
| Experimental project | Inhibiting rate (%) |
| Inhibit tyrosinase vigor | 85.6 |
| To superoxide anion scavenging effect | 71.5 |
| To Hydroxyl Radical Scavenging | 81.6 |
Comparative example 1:
2 parts of Salvia root P.E, 5 parts of Rhizoma Chuanxiong extract, 5 parts of angelica extract, 2 parts of radix paeoniae alba extraction, ginseng extract 3 are taken respectively
Part, after mixing, obtain the mixed liquor of Chinese medicinal compound extract.
Verification test is carried out to the mixed liquor that comparative example 1 obtains according to the above method, anti-senescence function evaluation experimental is as follows
Shown in table 3:
The experiment of 3 anti-aging result of table
| Experimental project | Inhibiting rate (%) |
| Inhibit tyrosinase vigor | 76.9 |
| To superoxide anion scavenging effect | 62.4 |
| To Hydroxyl Radical Scavenging | 75.9 |
Comparative example 2:
10 parts of beta glucan, 3 parts of vitamin B5,5 parts of glycine betaine, Cer NS part, 3 parts of compound essential oil, fullerene 3 are taken respectively
Part, 2 parts of tetrahydro methylpyrimidine carboxylic acid, 1 part of bisabolol, 0.3 part of xanthan gum, 0.1 part of macromolecular hyaluronic acid, small molecule are transparent
0.01 part of matter acid, after mixing, obtains anti-ageing composition.
Verification test, anti-senescence function evaluation experimental are carried out to the anti-ageing composition that comparative example 2 obtains according to the above method
It is as shown in table 4 below:
The experiment of 4 anti-aging result of table
| Experimental project | Inhibiting rate (%) |
| Inhibit tyrosinase vigor | 82.3 |
| To superoxide anion scavenging effect | 68.7 |
| To Hydroxyl Radical Scavenging | 80.1 |
Above-mentioned comparative example 1, comparative example of the comparative example 2 as embodiment 3, anti-aging evaluation experimental the result shows that, adopt
After being compounded with Chinese medical extract with other Multifunctional matters, the more single Chinese medical extract of anti-aging effects or single multi-functional object
The effect of matter is stronger, it is possible thereby to prove, synergistic effect is played after compounding.
Embodiment 4:
The present embodiment is related to a kind of Chinese medicine compound prescription and extracts application of the composition in cosmetics facial cleanser.
Chinese medicine compound prescription described in embodiment 3 is extracted into composition, facial cleanser is prepared by cold emulsification method processed.
Verification test is carried out to the facial cleanser that embodiment 4 obtains according to the above method, anti-senescence function evaluation experimental is as follows
Shown in table 5:
The experiment of 5 anti-aging result of table
| Experimental project | Inhibiting rate (%) |
| Inhibit tyrosinase vigor | 53.1 |
| To superoxide anion scavenging effect | 44.9 |
| To Hydroxyl Radical Scavenging | 60.5 |
Embodiment 5:
The present embodiment is related to a kind of Chinese medicine compound prescription and extracts application of the composition in cosmetics shower cream.
Chinese medicine compound prescription described in embodiment 3 is extracted into composition, shower cream is prepared by heat creams method.
Verification test is carried out to the shower cream that embodiment 5 obtains according to the above method, anti-senescence function evaluation experimental is as follows
Shown in table 6:
The experiment of 6 anti-aging result of table
| Experimental project | Inhibiting rate (%) |
| Inhibit tyrosinase vigor | 52.1 |
| To superoxide anion scavenging effect | 47.9 |
| To Hydroxyl Radical Scavenging | 55.5 |
Embodiment 6:
The present embodiment is related to a kind of Chinese medicine compound prescription and extracts application of the composition in cosmetic emulsion.
Chinese medicine compound prescription described in embodiment 3 is extracted into composition, lotion is prepared by heat creams method.
Verification test, anti-senescence function evaluation experimental such as the following table 7 are carried out to the lotion that embodiment 6 obtains according to the above method
It is shown:
The experiment of 7 anti-aging result of table
| Experimental project | Inhibiting rate (%) |
| Inhibit tyrosinase vigor | 79.3 |
| To superoxide anion scavenging effect | 66.1 |
| To Hydroxyl Radical Scavenging | 73.2 |
Embodiment 7:
The present embodiment is related to a kind of Chinese medicine compound prescription and extracts application of the composition in cosmetics face cream.
Chinese medicine compound prescription described in embodiment 3 is extracted into composition, face cream is prepared by heat creams method.
Verification test, anti-senescence function evaluation experimental such as the following table 8 are carried out to the face cream that embodiment 7 obtains according to the above method
It is shown:
The experiment of 8 anti-aging result of table
| Experimental project | Inhibiting rate (%) |
| Inhibit tyrosinase vigor | 77.1 |
| To superoxide anion scavenging effect | 64.9 |
| To Hydroxyl Radical Scavenging | 70.5 |
Embodiment 8:
The present embodiment is related to a kind of Chinese medicine compound prescription and extracts application of the composition in cosmetics Essence.
Chinese medicine compound prescription described in embodiment 3 is extracted into composition, Essence is prepared by mixed method.
Verification test is carried out to the Essence that embodiment 8 obtains according to the above method, anti-senescence function evaluation experimental is as follows
Shown in table 9:
The experiment of 9 anti-aging result of table
| Experimental project | Inhibiting rate (%) |
| Inhibit tyrosinase vigor | 84.2 |
| To superoxide anion scavenging effect | 69.7 |
| To Hydroxyl Radical Scavenging | 81.3 |
Embodiment 9:
The present embodiment is related to a kind of Chinese medicine compound prescription and extracts application of the composition in cosmetic mask.
Chinese medicine compound prescription described in embodiment 3 is extracted into composition, facial mask is prepared by mixed method.
Verification test, anti-senescence function evaluation experimental such as following table are carried out to the facial mask that embodiment 9 obtains according to the above method
Shown in 10:
The experiment of 10 anti-aging result of table
| Experimental project | Inhibiting rate (%) |
| Inhibit tyrosinase vigor | 82.8 |
| To superoxide anion scavenging effect | 69.5 |
| To Hydroxyl Radical Scavenging | 80.6 |
Comparative example 3:
Take 2 parts of Salvia root P.E, 2 parts of Rhizoma Chuanxiong extract, 2 parts of angelica extract, seven white powder (Rhizoma Atractylodis Macrocephalae, the root of Dahurain angelica, Radix Paeoniae Alba, white respectively
Liana, the bletilla striata, PORIA ALBA, the mixing of larva of a silkworm with batrytis equal proportion) 2 parts, 8 parts of beta glucan, 2 parts of PORIA ALBA, 1 part of vitamin B5, glycine betaine
1 part, it is Cer NS part, 1 part of compound essential oil, 0.5 part of bisabolol, 0.1 part of xanthan gum, 0.05 part of macromolecular hyaluronic acid, small
It 0.05 part of molecular weight hyaluronic acid, after mixing, obtains Chinese medicine compound prescription and extracts composition.
Verification test is carried out to the composition that comparative example 3 obtains according to the above method, anti-senescence function evaluation experimental is as follows
Shown in table 11:
The experiment of 11 anti-aging result of table
| Experimental project | Inhibiting rate (%) |
| Inhibit tyrosinase vigor | 85.2 |
| To superoxide anion scavenging effect | 72.1 |
| To Hydroxyl Radical Scavenging | 81.8 |
By above-mentioned composition, lotion is prepared by heat creams method.Anti-aging verification test, anti-aging function are carried out to it
Energy evaluation experimental is as shown in table 12 below:
The experiment of 12 anti-aging result of table
| Experimental project | Inhibiting rate (%) |
| Inhibit tyrosinase vigor | 84.5 |
| To superoxide anion scavenging effect | 70.2 |
| To Hydroxyl Radical Scavenging | 81.9 |
Comparative example 4:
3 parts of Rhizoma Chuanxiong extract, 3 parts of angelica extract, 3 parts of radix paeoniae alba extraction, 3 parts of ginseng extract, beta glucan 8 are taken respectively
Part, 1 part of vitamin B5,1 part of glycine betaine, 1 part of compound essential oil, 2 parts of fullerene, 0.1 part of xanthan gum, macromolecular hyaluronic acid
0.05 part, 0.05 part of micromolecule hyaluronic acid after mixing, obtain Chinese medicine compound prescription and extract composition.
Verification test is carried out to the composition that comparative example 4 obtains according to the above method, anti-senescence function evaluation experimental is as follows
Shown in table 13:
The experiment of 13 anti-aging result of table
| Experimental project | Inhibiting rate (%) |
| Inhibit tyrosinase vigor | 82.2 |
| To superoxide anion scavenging effect | 68.7 |
| To Hydroxyl Radical Scavenging | 78.5 |
By above-mentioned composition, Essence is prepared by mixed method.Anti-aging verification test, anti-senescence function are carried out to it
Evaluation experimental is as shown in table 14 below:
The experiment of 14 anti-aging result of table
| Experimental project | Inhibiting rate (%) |
| Inhibit tyrosinase vigor | 83.1 |
| To superoxide anion scavenging effect | 68.2 |
| To Hydroxyl Radical Scavenging | 77.9 |
Comparative example 5:
Take respectively 2 parts of Salvia root P.E, 2 parts of angelica extract, 2 parts of radix paeoniae alba extraction, 8 parts of beta glucan, 1 part of vitamin B5,
1 part of glycine betaine, Cer NS part, 1 part of compound essential oil, 1 part of fullerene, 0.3 part of tetrahydro methylpyrimidine carboxylic acid, bisabolol 0.5
Part, 0.1 part of xanthan gum, 0.05 part of macromolecular hyaluronic acid, 0.05 part of micromolecule hyaluronic acid, after mixing, obtain buff, are in
The watery Chinese medicine compound prescription of stiff extracts composition.
Verification test is carried out to the composition that comparative example 5 obtains according to the above method, anti-senescence function evaluation experimental is as follows
Shown in table 15:
The experiment of 15 anti-aging result of table
| Experimental project | Inhibiting rate (%) |
| Inhibit tyrosinase vigor | 83.5 |
| To superoxide anion scavenging effect | 66.2 |
| To Hydroxyl Radical Scavenging | 79.5 |
By above-mentioned composition, face cream is prepared by heat creams method.Anti-aging verification test, anti-aging function are carried out to it
Energy evaluation experimental is as shown in table 16 below:
The experiment of 16 anti-aging result of table
| Experimental project | Inhibiting rate (%) |
| Inhibit tyrosinase vigor | 81.5 |
| To superoxide anion scavenging effect | 63.8 |
| To Hydroxyl Radical Scavenging | 78.8 |
Above-mentioned comparative example 3, the comparative example of comparative example 4, comparative example 5 as embodiment 3, have modified the Chinese medicine preparation group of component
Object is closed, when carrying out the test of anti-aging result, inhibiting rate decline, and in the application process of cosmetic emulsion, anti-ageing effect
Fruit decline.
Take the Essence of the lotion (experimental group 1) of above-described embodiment 6, the face cream (experimental group 2) of embodiment 7, embodiment 8
Essence (the experiment of the facial mask (experimental group 4) of (experimental group 3), embodiment 9, the lotion (experimental group 5) of comparative example 3, comparative example 4
Group 6), the face cream of comparative example 5 (experimental group 7), pure water (blank control) by standard QB/T4256-2011 carry out skin moisture content
(MMV) it tests.Test subject is sat quietly 30min in constant temperature and humidity room, is taken inboard arm partial skin (4cm*4cm), is used respectively
The moisture of the skin of Corneometer CM825 moisture of skin test probe test；With same way respectively by above-mentioned experiment
Group cosmetics are pasted on skin 15min, and test a moisture at regular intervals, record moisture content of skin.Experimental result ginseng
It see the table below 17.
17 human skin moisture content table of table
Take the Essence (experiment of the lotion (experimental group 1) of above-described embodiment 6, the face cream (experimental group 2) of embodiment 7, embodiment 8
Group 3), the Essence (experimental group 6) of the lotion (experimental group 5) of the facial mask of embodiment 9 (experimental group 4), comparative example 3, comparative example 4,
The face cream (experimental group 7) of comparative example 5 carries out stratum corneum barrier function and repairs evaluation experimental.
Experimental method: selecting the age at 25-40 years old, and face skin has obvious red, the symptoms such as itch, do volunteer and is total to
70, every group each 10, after cosmetics to be tested, TEWL(is carried out through epidermis dehydration to its skin) test.Experiment knot
Fruit is referring to the following table 18 .1 to table 18.7.
Tables of data (one) is evaluated in 18.1 stratum corneum barrier function reparation of table
Tables of data (two) are evaluated in 18.2 stratum corneum barrier function reparation of table
Tables of data (three) are evaluated in 18.3 stratum corneum barrier function reparation of table
Tables of data (four) are evaluated in 18.4 stratum corneum barrier function reparation of table
Tables of data (five) are evaluated in 18.5 stratum corneum barrier function reparation of table
Tables of data (six) are evaluated in 18.6 stratum corneum barrier function reparation of table
Tables of data (seven) are evaluated in 18.7 stratum corneum barrier function reparation of table
Based on upper table 17, table 18.1 to table 18.7 it is recognised that the cosmetics for being respectively related to embodiment 6-9 carry out moisture of skin
Content (MMV) and the measurement through epidermis dehydration (TEWL), the makeup that moistening effect is apparently higher than comparative example 3, comparative example 4 is related to
Product, and the cosmetics that embodiment 6-9 is related to also have effects that repairing stratum corneum barrier function is damaged.
The above is only presently preferred embodiments of the present invention, not does limitation in any form to the present invention, it is all according to
According to technical spirit any simple modification to the above embodiments of the invention, equivalent variations, protection of the invention is each fallen within
Within the scope of.
Claims (3)
1. a kind of Chinese medicine compound prescription extracts composition, it is characterised in that: the component including following parts by weight: Salvia root P.E 2~
10 parts, 2~10 parts of Rhizoma Chuanxiong extract, 2~10 parts of angelica extract, 2~10 parts of radix paeoniae alba extraction, 2~10 parts of ginseng extract,
1~10 part of beta glucan, 2~5 parts of vitamin B5,2~5 parts of glycine betaine, Cer NS~5 part, 0.1~5 part of compound essential oil,
It is fuller olefinic carbon 60 .1~3 part, 0.1~2 part of tetrahydro methylpyrimidine carboxylic acid, 0.1~1 part of bisabolol, 0.1~0.3 part of xanthan gum, big
0.01~0.1 part of molecular weight hyaluronic acid, 0.01~0.1 part of micromolecule hyaluronic acid.
2. a kind of Chinese medicine compound prescription according to claim 1 extracts composition, it is characterised in that: including following parts by weight
Component: 2 parts of Salvia root P.E, 2 parts of Rhizoma Chuanxiong extract, 2 parts of angelica extract, 2 parts of radix paeoniae alba extraction, 2 parts of ginseng extract, β-
Dextran 8 part, 1 part of vitamin B5,1 part of glycine betaine, Cer NS part, 1 part of compound essential oil, 1 part of fullerene, tetrahydro methyl are phonetic
0.3 part of pyridine carboxylic acid, 0.5 part of bisabolol, 0.1 part of xanthan gum, 0.05 part of macromolecular hyaluronic acid, micromolecule hyaluronic acid 0.05
Part.
3. a kind of Chinese medicine compound prescription according to claim 1 extracts application of the composition in cosmetics, it is characterised in that: will
The Chinese medicine compound prescription is extracted composition and is applied in facial cleanser, shower cream, lotion, frost, Essence and facial mask.
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