CN109846762A - A kind of composition with white-skinned face function and preparation method thereof, application - Google Patents
A kind of composition with white-skinned face function and preparation method thereof, application Download PDFInfo
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Abstract
The present invention relates to cosmetic technical fields more particularly to a kind of composition with white-skinned face function and preparation method thereof, application.On the basis of medicinal material dry weight, the composition with white-skinned face function is made of raw material from the following weight: 1 ~ 20 part of Herba Cistanches, 1 ~ 20 part of Poria cocos, 1 ~ 20 part of Radix Astragali, 1 ~ 20 part of Radix Angelicae Sinensis, 1 ~ 20 part of Rhizoma Chuanxiong.Composition of the invention reaches skin whitening, the more potent whitening function such as facial colour spot reduction by cistanche extracts, tuckahoe extracts, Astragalus Root P.E, the mutual aid collaboration of four kinds of components of angelica extract and Rhizoma Chuanxiong extract, synergy；Preparation process condition is mild, and recovery rate is high, and to equipment without particular/special requirement, preparation cost is low, is conducive to large-scale industrialized production.
Description
Technical field
The present invention relates to cosmetic technical fields more particularly to a kind of with the composition of white-skinned face function and its preparation side
Method, application.
Background technique
If Asia women pursues always the white congealed fat of skin.However since work rhythm is fast, psychological pressure is big, endocrine is lost
Phenomena such as influence of the internal and external factors such as tune, environmental pollution, skin also accordingly will appear obscure, pigmentation, therefore whitening is skin
Skin nurses one of most important theme.
Usually said melanin is primarily referred to as excellent melanocyte and pheomelanin.Modern beauty medicine shows that melanin is to pass through
What a series of oxidation reactions were formed: tyrosinase, dopachrome tautomerase, 5,6- dihydroxy indole carboxylic oxidase this
Under the participation of three kinds of enzyme different phases, the tyrosine in melanocyte generates 5,6- dihydroxy indole carboxylic by series reaction
Acid is to form excellent melanocyte；Intermediate product DOPA meanwhile under the catalysis of cysteine or glutathione, in above-mentioned reaction process
Quinone is converted into cysteinyl dopa or glutathione DOPA, ultimately produces pheomelanin.In turn, melanocyte tissue is by black
Element is transferred in Epidermal basal layer cells, is brought in cuticula with the metabolism of cell, finally with keratinocyte
It falls off.
There are many mechanism of skin-whitening, such as: defence ultraviolet radiation inhibits tyrosinase/DOPA in melanocyte
Interconvertible enzyme and 5,6- dihydroxy indole carboxylic acid oxidative enzymatic activity improve body superoxide dismutase activity and remove extra super oxygen certainly
Updated by base, the transfer of inhibition melanocyte, promotion horn cell etc..
Currently, the whitening additive mechanism used in cosmetic product is more single, mainly to inhibit tyrosine enzyme activity
Property based on, lack number of mechanisms integrated use and in order to develop effect skin-lightening cosmetic more outstanding then need number of mechanisms
Integrated use preferably to achieve the purpose that skin whitening.
Summary of the invention
The present invention provides one kind and is compounded by natural plant extracts to overcome above-mentioned problems of the prior art
Made of the composition with white-skinned face function, dermal melanin can be reduced from number of ways, and there are a variety of benefits to skin
Benefit effect.
The present invention also provides a kind of preparation methods of composition with white-skinned face function, and this method process conditions are mild,
Recovery rate is high, to equipment without particular/special requirement, is conducive to large-scale industrialized production.
The present invention also provides a kind of application of composition with white-skinned face function in cosmetics.
To achieve the goals above, the invention adopts the following technical scheme:
A kind of composition with white-skinned face function, the composition with white-skinned face function includes cistanche extracts, and Poria cocos mentions
Take object, Astragalus Root P.E, angelica extract and Rhizoma Chuanxiong extract.
The present invention passes through cistanche extracts, tuckahoe extracts, Astragalus Root P.E, angelica extract and Rhizoma Chuanxiong extract four
The mutual aid collaboration of kind component, synergy reach skin whitening, the more potent whitening function such as facial colour spot reduction.This hair
The bright composition with white-skinned face function is based on following lightening mechanism research and development gained: ultraviolet light is to cause melanin to generate to decline with skin
The main reason for old, many active constituents in natural plants have good absorption action of ultraviolet radiation, can mitigate ultraviolet light
The radiation injury caused by skin；Endothelin -1 and Vasoactive intestinal constrictor be in the forming process of melanin 2 kinds it is indispensable extracellular
Substance, they are by conjunction with receptor-specific on melanocyte film, promoting melanocyte differen-tiation and activating tyrosinase, naturally
Plant component is safely and effectively endothelin antagonist, can by with endothelin receptor competitive binding, to play inhibition
The effect that melanocyte generates；In addition, the moisturizing ingredient in natural plants has enhancing skin barrier function, extraneous thorn can be resisted
Swash, so that booster action is played to whitening, it is contained by Herba Cistanches, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Astragali, the use of Poria cocos collocation together
Chemical component has effects that tonifying Qi, replenishing and activating blood, to play further under the premise of improving white-skinned face function to skin
Benefiting action.
Each component effect and synergistic effect are as follows in inventive formulation: the representative component echinacoside of Herba Cistanches has antioxygen
Change effect, acteoside has simultaneously to be inhibited tyrosinase activity and antioxidation, plays the function of whitening and anti-aging
Effect.It is rich in ferulic acid this kind cinnamic acid derivative in Radix Angelicae Sinensis and Rhizoma Chuanxiong, there is anti-oxidant, inhibition tyrosinase and resists
Ultraviolet radioactive effect.In addition, ferulic acid or endothelin-receptor antagonists, it can be by being risen with endothelin receptor competitive binding
To the effect for inhibiting melanin to generate.It is rich in polysaccharide component in Herba Cistanches, Poria cocos and Radix Astragali, can be formed in skin surface
Water lock film improves moisture content of skin and reduces percutaneous moisture loss, to play moisturizing and maintenance skin barrier effect, while Fu
Siberian cocklebur can inhibit tyrosinase activity with two kinds of polysaccharide of Radix Astragali, therefore also have white-skinned face function.
Preferably, on the basis of medicinal material dry weight, the composition with white-skinned face function by following parts by weight raw material
It is made: 1 ~ 20 part of Herba Cistanches, 1 ~ 20 part of Poria cocos, 1 ~ 20 part of Radix Astragali, 1 ~ 20 part of Radix Angelicae Sinensis, 1 ~ 20 part of Rhizoma Chuanxiong.
The present invention is based on the comprehensive consideration of various factors synthesis to skin-whitening is influenced, compatibility and association from each component
The same sex, inhibit tyrosinase and resist ultraviolet radioactive, reduce pigment deposition and promote excoriation angularly use it is comprehensive
Formula rate combination, proportioning equalize, compatibility is reasonable, and without adding any preservative, safety in utilization, stability and appearance are dry
It is good, no greasy feeling small to skin irritatin, can rapid osmotic skin, reach skin whitening, it is more potent that facial colour spot is reduced etc.
Whitening function.
A kind of preparation method of the composition with white-skinned face function, comprising the following steps:
(1) raw material is weighed according to said ratio, respectively extracted Herba Cistanches, Poria cocos, Radix Astragali with ethanol water, combined extract
Extracting solution A is obtained, merges the dregs of a decoction and obtains the dregs of a decoction to be recycled；
(2) dregs of a decoction to be recycled that step (1) obtains are added water to cook, is filtered to get filtrate, simultaneously centrifugal filtration must clarify concentration filtrate
Ethanol water is added into clear solution for solution, stands overnight, and next day centrifugal filtration obtains the thick of Herba Cistanches, Poria cocos and Radix Astragali
Polysaccharide extraction liquid is denoted as extracting solution B；The dregs of a decoction are further extracted, the recovery rate of effective extract in medicinal material, the utilization of resources are improved
Rate is high；
(3) Radix Angelicae Sinensis, Rhizoma Chuanxiong are extracted with ethanol water, combined extract obtains extracting solution C；
(4) combined extract A and extracting solution C is concentrated 10 ~ 50 times after filtering, eluent is concentrated 10 ~ 20 times by purifying, elution,
Obtain concentrate；
(5) combined extract B and concentrate are added 1,3-BDO, stand after mixing evenly, supernatant liquor is taken to be centrifuged, obtain
Centrifuged supernatant is to get the composition with white-skinned face function.
Preparation process of the invention is distributed rationally based on each component in the composition with white-skinned face function,
It is rich in polysaccharide component in Herba Cistanches, Poria cocos and Radix Astragali, asafoetide acids cinnamic acid derivative is rich in Radix Angelicae Sinensis and Rhizoma Chuanxiong, therefore is divided
Two batches are extracted and combined extract；Using substep mixing and to the second extraction technique of the dregs of a decoction, then medicinal material can be effectively improved
Recovery rate, resource utilization is high, save the cost.Preferably, the volumetric concentration of ethanol water is 50 in step (1) and (3)
~100%；The additional amount of the ethanol water is 5 ~ 20 times of amounts, and described times of amount is that volume/medicinal material weight of ethanol water is [molten
Liquid product (ml): medicinal material weight (g)].
Preferably, Extracting temperature is 30 ~ 80 DEG C in step (1) and (3)；Extraction time is 1 ~ 3 time；Extracting temperature compared with
Be it is mild, avoid white-skinned face function ingredient susceptible to hydrolysis in medicinal material from decomposing or hydrolyze during the extraction process.
Preferably, being purified in step (4) using macroporous absorbent resin；Eluant, eluent used is body in elution processes
The ethanol water that product concentration is 10 ~ 95%.
Preferably, the volumetric concentration of the ethanol water is 95% in step (2)；The addition of the ethanol water
Amount is 1 ~ 5 times of clear solution volume.
Preferably, the additional amount of the 1,3-BDO is volume after extracting solution B and concentrate merging in step (5)
0.5 ~ 3 times.
A kind of application of the composition with white-skinned face function in cosmetics, the cosmetics are whitening class, nti-freckle class, light
Spot class eliminates melanin class or desalination skin color class cosmetic formulations；The cosmetic formulations be facial cleanser, face cream, facial mask,
Essence, toner, lotion, gel or aqua；It is direct that there is the present invention composition of white-skinned face function also can be used as whitening product
It uses.
Therefore, the invention has the following beneficial effects:
(1) composition of the invention passes through cistanche extracts, tuckahoe extracts, Astragalus Root P.E, angelica extract and Rhizoma Chuanxiong
The mutual aid of four kinds of components of extract cooperates with, synergy, reaches skin whitening, and the more potent whitening such as facial colour spot reduction is made
With；
(2) preparation process condition of the invention is mild, and recovery rate is high, and to equipment without particular/special requirement, preparation cost is low, is conducive to big
Scale industrialization production；
(3) composition with white-skinned face function of the invention has broad application prospects, can be direct directly as whitening product
It uses, it can also application by reasonably combined with other kinds effective component, for all kinds of cosmetics.
Specific embodiment
Below by specific embodiment, the technical solutions of the present invention will be further described.
In the present invention, if not refering in particular to, all devices and raw material is commercially available or the industry is common are following
Method in embodiment is unless otherwise instructed conventional method in that art.
Embodiment 1
(1) raw material is weighed according to quality proportioning in table 1: Herba Cistanches 100g, Poria cocos 100g, Radix Astragali 100g, Radix Angelicae Sinensis 100g, Rhizoma Chuanxiong
100g；It is 100% that Herba Cistanches, Poria cocos, Radix Astragali, which are measured [liquor capacity (ml): medicinal material weight (g)] volumetric concentration with 5 times, respectively
Ethanol water extracts, and Extracting temperature is 30 DEG C；Extraction time is 3 times, and combined extract obtains extracting solution A, merges the dregs of a decoction and obtains
To the dregs of a decoction to be recycled；
(2) dregs of a decoction to be recycled that step (1) obtains are added water to cook, is filtered to get filtrate, simultaneously centrifugal filtration must clarify concentration filtrate
The ethanol water that volumetric concentration is 95% is added into clear solution, stands overnight, next day centrifugal filtration obtains meat desert for solution
The Thick many candies extracting solution of Rong, Poria cocos and Radix Astragali, are denoted as extracting solution B；
(3) Radix Angelicae Sinensis, Rhizoma Chuanxiong are measured into the ethanol water that [liquor capacity (ml): medicinal material weight (g)] volumetric concentration is 100% with 5 times
It extracts, Extracting temperature is 30 DEG C；Extraction time is 3 times, and combined extract obtains extracting solution C；
(4) combined extract A and extracting solution C, after filtering be concentrated 10 times, use macroporous absorbent resin to be purified, eluant, eluent for
Eluent is concentrated 10 times, obtains concentrate by the ethanol water that volumetric concentration is 10%；
(5) combined extract B and concentrate are added 0.5 times of 1,3-BDO, stand after mixing evenly, take supernatant liquor from
The heart obtains centrifuged supernatant to get the composition with white-skinned face function.
Embodiment 2
(1) raw material is weighed according to quality proportioning in table 1: Herba Cistanches 5g, Poria cocos 100g, Radix Astragali 5g, Radix Angelicae Sinensis 5g, Rhizoma Chuanxiong 5g；Respectively
Herba Cistanches, Poria cocos, Radix Astragali are measured into the ethanol water that [liquor capacity (ml): medicinal material weight (g)] volumetric concentration is 50% with 20 times
It extracts, Extracting temperature is 80 DEG C；Extraction time is 1 time, and combined extract obtains extracting solution A, merges the dregs of a decoction and obtains medicine to be recycled
Slag；
(2) dregs of a decoction to be recycled that step (1) obtains are added water to cook, is filtered to get filtrate, simultaneously centrifugal filtration must clarify concentration filtrate
The ethanol water that volumetric concentration is 95% is added into clear solution, stands overnight, next day centrifugal filtration obtains meat desert for solution
The Thick many candies extracting solution of Rong, Poria cocos and Radix Astragali, are denoted as extracting solution B；
(3) Radix Angelicae Sinensis, Rhizoma Chuanxiong are measured into the ethanol water that [liquor capacity (ml): medicinal material weight (g)] volumetric concentration is 50% with 20 times
It extracts, Extracting temperature is 80 DEG C；Extraction time is 1 time, and combined extract obtains extracting solution C；
(4) combined extract A and extracting solution C, after filtering be concentrated 50 times, use macroporous absorbent resin to be purified, eluant, eluent for
Eluent is concentrated 20 times, obtains concentrate by the ethanol water that volumetric concentration is 10 ~ 95%；
(5) combined extract B and concentrate are added 3 times of 1,3-BDO, stand after mixing evenly, supernatant liquor is taken to be centrifuged,
Centrifuged supernatant is obtained to get the composition with white-skinned face function.
Embodiment 3
(1) raw material is weighed according to quality proportioning in table 1: Herba Cistanches 50g, Poria cocos 75g, Radix Astragali 70g, Radix Angelicae Sinensis 75g, Rhizoma Chuanxiong 60g；Point
It is water-soluble that Herba Cistanches, Poria cocos, Radix Astragali the ethyl alcohol that [liquor capacity (ml): medicinal material weight (g)] volumetric concentration is 80% is not measured into 10 times
Liquid extracts, and Extracting temperature is 50 DEG C；Extraction time is 2 times, and combined extract obtains extracting solution A, and the merging dregs of a decoction obtain to be recycled
The dregs of a decoction；
(2) dregs of a decoction to be recycled that step (1) obtains are added water to cook, is filtered to get filtrate, simultaneously centrifugal filtration must clarify concentration filtrate
The ethanol water that volumetric concentration is 95% is added into clear solution, stands overnight, next day centrifugal filtration obtains meat desert for solution
The Thick many candies extracting solution of Rong, Poria cocos and Radix Astragali, are denoted as extracting solution B；
(3) Radix Angelicae Sinensis, Rhizoma Chuanxiong are measured into the ethanol water that [liquor capacity (ml): medicinal material weight (g)] volumetric concentration is 60% with 15 times
It extracts, Extracting temperature is 60 DEG C；Extraction time is 2 times, and combined extract obtains extracting solution C；
(4) combined extract A and extracting solution C, after filtering be concentrated 40 times, use macroporous absorbent resin to be purified, eluant, eluent for
Eluent is concentrated 15 times, obtains concentrate by the ethanol water that volumetric concentration is 50%；
(5) combined extract B and concentrate are added 2 times of 1,3-BDO, stand after mixing evenly, supernatant liquor is taken to be centrifuged,
Centrifuged supernatant is obtained to get the composition with white-skinned face function.
Comparative example 1
Comparative example 1 the difference from embodiment 1 is that, raw material proportioning is different, does not include Herba Cistanches, is shown in Table 1；Remaining step and technique
Condition is identical.
Comparative example 2
Comparative example 2 the difference from embodiment 1 is that, raw material proportioning is different, does not include Poria cocos, and the ratio of Radix Astragali increases, and is shown in Table
1；Remaining step is identical with process conditions.
Comparative example 3
Comparative example 3 the difference from embodiment 1 is that, raw material proportioning is different, and the ratio of Herba Cistanches increases, and is shown in Table 1；Remaining step with
Process conditions are identical.
Comparative example 4
Comparative example 4 is newborn using the whitening of the arbutin containing 2%.
The composition of raw materials table of table 1. embodiment 1-3 and comparative example 1-3
To effect evaluation of the composition of embodiment 1-3 and comparative example 1-4 on clinical pattern, experimental program:
The whitening cream containing 2% arbutin respectively with the composition of embodiment 1-3 and comparative example 1-3 containing 5%, comparative example 4 is every
2 times are applied to the specified region of inboard arm sooner or later for it, detect background values before smearing within the 1st day, the same time detects skin every 1 weeks later
Skin melanin, the results are shown in Table 2.
2. testing result of table
As can be seen from Table 1, comparative example 1-3 and comparative example 4, compared with matrix cream, smearing 5% of the invention has
The composition of white-skinned face function started to show significant difference in the 1st week reduction melanin value about 3.64% or so at the 5th week, and
The whitening effect of the effect whitening cream stronger than the arbutin containing 2% is good, the 7th week most strong, can achieve 12.3%, and more significant
It is better than 2% arbutin (7.07).Therefore, in the evaluation of clinical long-acting whitening, there is whitening function using containing 5% of the invention
The whitening cream of the composition of effect has the whitening effect become apparent.
Embodiment 1 and comparative example 1-3 are compared, it can be clearly seen that in the composition with white-skinned face function of the invention
Four kinds of formulas meet " component+content " (Herba Cistanches 1 ~ 20%, Poria cocos 1 ~ 20%, Radix Astragali 1 ~ 20%, Radix Angelicae Sinensis 1 ~ 20%, Rhizoma Chuanxiong 1 at the same time
~ 20%) in the case where, there can be permanent, significant whitening effect, reduce any component (comparative example 1 and 2) or adjustment
The proportion of any component (comparative example 2 and 3) except formula can cause whitening effect significantly to detract.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the present invention in any form, and is not surpassing
There are also other variations and modifications under the premise of technical solution documented by claim out.
Claims (9)
1. a kind of composition with white-skinned face function, which is characterized in that the composition with white-skinned face function includes Herba Cistanches
Extract, tuckahoe extracts, Astragalus Root P.E, angelica extract and Rhizoma Chuanxiong extract.
2. a kind of composition with white-skinned face function according to claim 1, which is characterized in that using medicinal material dry weight as base
Standard, the composition with white-skinned face function are made of raw material from the following weight: 1 ~ 20 part of Herba Cistanches, 1 ~ 20 part of Poria cocos, yellow
1 ~ 20 part of stilbene, 1 ~ 20 part of Radix Angelicae Sinensis, 1 ~ 20 part of Rhizoma Chuanxiong.
3. a kind of preparation method of the composition with white-skinned face function as claimed in claim 2, which is characterized in that including following
Step:
(1) raw material is weighed according to said ratio, respectively extracted Herba Cistanches, Poria cocos, Radix Astragali with ethanol water, combined extract
Extracting solution A is obtained, merges the dregs of a decoction and obtains the dregs of a decoction to be recycled；
(2) dregs of a decoction to be recycled that step (1) obtains are added water to cook, is filtered to get filtrate, simultaneously centrifugal filtration must clarify concentration filtrate
Ethanol water is added into clear solution for solution, stands overnight, and next day centrifugal filtration obtains the thick of Herba Cistanches, Poria cocos and Radix Astragali
Polysaccharide extraction liquid is denoted as extracting solution B；
(3) Radix Angelicae Sinensis, Rhizoma Chuanxiong are extracted with ethanol water, combined extract obtains extracting solution C；
(4) combined extract A and extracting solution C is concentrated 10 ~ 50 times after filtering, eluent is concentrated 10 ~ 20 times by purifying, elution,
Obtain concentrate；
(5) combined extract B and concentrate are added 1,3-BDO, stand after mixing evenly, supernatant liquor is taken to be centrifuged, obtain
Centrifuged supernatant is to get the composition with white-skinned face function.
4. the preparation method of the composition according to claim 3 with white-skinned face function, which is characterized in that step (1) and
(3) in, the volumetric concentration of ethanol water is 50 ~ 100%；The additional amount of the ethanol water is 5 ~ 20 times of amounts, described times of amount
For volume/medicinal material weight of ethanol water.
5. the preparation method of the composition according to claim 3 or 4 with white-skinned face function, which is characterized in that step (1)
(3) in, Extracting temperature is 30 ~ 80 DEG C；Extraction time is 1 ~ 3 time.
6. the preparation method of the composition according to claim 3 with white-skinned face function, which is characterized in that in step (4),
It is purified using macroporous absorbent resin；Eluant, eluent used is the ethanol water that volumetric concentration is 10 ~ 95% in elution processes.
7. the preparation method of the composition according to claim 3 with white-skinned face function, which is characterized in that in step (2),
The volumetric concentration of the ethanol water is 95%；The additional amount of the ethanol water is 1 ~ 5 times of clear solution volume.
8. the preparation method of the composition according to claim 3 with white-skinned face function, which is characterized in that in step (5),
The additional amount of the 1,3 butylene glycol is 0.5 ~ 3 times of volume after extracting solution B and concentrate merging.
9. a kind of application of the composition with white-skinned face function in cosmetics as claimed in claim 1 or 2.
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