CN110433122A - A kind of composition and its application in the skin care item for preparing light speckles, beautification and white - Google Patents
A kind of composition and its application in the skin care item for preparing light speckles, beautification and white Download PDFInfo
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- CN110433122A CN110433122A CN201910859344.0A CN201910859344A CN110433122A CN 110433122 A CN110433122 A CN 110433122A CN 201910859344 A CN201910859344 A CN 201910859344A CN 110433122 A CN110433122 A CN 110433122A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
The present invention relates to cosmetic technical field more particularly to a kind of composition and its applications in the skin care item for preparing light speckles, beautification and white.Composition provided by the invention includes: ginsenoside, arbutin, albiflorin, oleanolic acid, Rhizoma Atractylodis Macrocephalae extract, bletilla striata extract, angelica extract.The composition, which passes through, the synergistic effect such as inhibits tyrosinase activity, removes DPPH free radical, replenishes qi to invigorate the spleen, and reduces dermal melanin index level, reduces dermal melanin and generates, and alleviation cutaneous pigmentation improves the colour of skin to achieve the effect that whitening spot-removing.
Description
Technical field
The present invention relates to cosmetic technical field more particularly to a kind of composition and its in the skin care item for preparing light speckles, beautification and white
In application.
Background technique
From ancient times to the present, the pale skin of health is always the target that Nails are pursued, whitening product also Asia always
The theme of area's cosmetics, wide market.Currently, up to thousand kinds of whitening and skin-protecting product available on the market, according to raw material
Source can be divided mainly into chemical classes, natural plant kind and biological species.Chemical classes whitening agent directly destroys melanocyte mostly and reaches
To whitening effect, effect is obvious but cytotoxicity is larger, and security risk is uncontrollable.Although biological species whitening agent safe source, effect
Fruit is ideal, but due to the limitation of its technology, there are production cycle length, low output, it is at high cost the problems such as.And it is natural
Plant whitening agent is cheap and easy to get, safety is good, whitening spot-removing effect is good, by the increasingly favor of R&D and production and consumer,
It is also research hotspot in recent years.
The colour of skin of people is by the distribution content and optical fiber of pigments all kinds of in skin in factors such as the absorption scatterings of skin surface
It determines, wherein the content of melanocyte and distribution are to determine the principal element of skin color.Melanocyte is that the enzyme of phenolic substance was aoxidizing
The general name of the high score daughter cell formed in journey, the approach formed are as follows: tyrosine → DOPA → DOPA quinone → DOPA mostly element → bis-
Oxyindole → melanin, DOPA quinone can also form brown pigment under the action of glutathione or cysteine.Wherein, initially
The reaction of tyrosine formation dopamine is the fast control stage that melanin is formed, and tyrosinase is rate-limiting enzyme, therefore inhibits junket ammonia
Phytase activity can effectively reduce the effect of generation of melanin is to reach whitening.In addition, blood follows unsmooth or blood in skin corium
Pipe fullness degree not enough also results in the obscure tarnish of skin.
Based on this, the present invention is using the good active Chinese medical extract of biological safety as raw material, from melanocyte formation basic theory,
Based on Traditional Chinese medical theory, in conjunction with the research achievement of modern Chinese herbal medicine effective component, by improving skin blood circulation, inhibiting
The approach such as tyrosinase and anti-oxidation protection play Whitening, spot effect with the thinking of multicomponent multiple target effect, to reach
Improve the effect of the colour of skin, healthy whitening.
Summary of the invention
In view of this, the technical problem to be solved in the present invention is that providing a kind of composition and its preparing light speckles, beautification and white
Application in skin care item, the composition has good tyrosinase activity activity inhibition, and has good free radical
Elimination effect, and it is non-stimulated to skin safe.
Composition provided by the invention, comprising: ginsenoside, arbutin, albiflorin, oleanolic acid, Rhizoma Atractylodis Macrocephalae extract, white
Splendid achnatherum extract, angelica extract.
In the embodiment of the present invention, the composition is grouped as by the group of following mass parts:
In the embodiment of the present invention, the ginsenoside is ginseng diol type saponin(e.
In some embodiments, the composition is grouped as by the group of following mass parts:
In some specific embodiments, the composition is grouped as by the group of following mass parts:
In some specific embodiments, the composition is grouped as by the group of following mass parts:
In some specific embodiments, the composition is grouped as by the group of following mass parts:
In some specific embodiments, the composition is grouped as by the group of following mass parts:
Application of the composition of the present invention in preparation removing free radical, the skin care item inhibited tyrosinase activity.
The free radical of composition removing of the present invention is DPPH free radical.
The present invention also provides a kind of skin care item of light speckles, beautification and white comprising composition of the present invention.
In the skin care item, the mass fraction of the composition is 1.35%~50%.
In some embodiments, the mass fraction of composition is 20.5%~32.5% in skin care item of the present invention.
In the skin care item, including following mass fraction:
In skin care item of the present invention:
The emulsifier is Tween-80, lecithin, polyethylene glycol -600, soybean lecithin, the pungent capric acid glycerol of polyethylene glycol
Ester, Arlacel-83, polyoxyethylene (40) rilanit special, polyoxyethylene (60) rilanit special, Bo Luosha
At least one of nurse 188；
The assistant for emulsifying agent is dehydrated alcohol, ethylene glycol, 1,2-PD, glycerine, polyethylene glycol -400, polyglycerol ester
At least one of；
The thickening stabilizing agent is alginic acid, in pectin, carbomer, sodium carboxymethylcellulose, Arabic gum, tragacanth
It is at least one；
The moisturizer is glycerine, butanediol, hexylene glycol, pentanediol, caprylic/capric triglyceride, sorbierite, urine
At least one of element, Sodium Hyaluronate, isopropyl palmitate, chondroitin sulfate, panthenol, polysaccharides.
In some embodiments, the composition is grouped as by the group of following mass fraction:
In some embodiments, the composition is grouped as by the group of following mass fraction:
In some embodiments, the composition is grouped as by the group of following mass fraction:
In some embodiments, the composition is grouped as by the group of following mass fraction:
It further include preservative and pH adjusting agent in skin care item of the present invention；
Wherein preservative is Phenoxyethanol；
PH adjusting agent is selected from sodium citrate, sodium lactate or lactic acid；
The pH value of the skin care item is 6.5~6.8.
The preparation method of skin care item of the present invention, comprising:
By ginsenoside, arbutin, Rhizoma Atractylodis Macrocephalae extract, emulsifier, assistant for emulsifying agent, thickener, moisturizer, preservative and go
Ionized water mixing is heated to 40~50 DEG C of dissolutions, is A phase；
Saualane and coconut oil are mixed and are preheated to 50~55 DEG C of obtained oil phase substrate, by albiflorin, oleanolic acid, white
Splendid achnatherum extract, angelica extract are dissolved in the oil phase substrate, are B phase；
The B phase is cooled to 40 DEG C, is mixed with the A, high-pressure homogeneous 10~15 circulations are rear to adjust pH to 6.5
~6.8, the skin care item are made.
In the present invention, the high-pressure homogeneous pressure is 500bar~900bar.
Composition provided by the invention includes: ginsenoside, arbutin, albiflorin, oleanolic acid, Rhizoma Atractylodis Macrocephalae extract, white
Splendid achnatherum extract, angelica extract.Through laser doppler technology, tyrosine enzyme activity Inhibition test and DPPH etc. it is experimentally confirmed that the group
Closing object can be by improving skin blood circulation, inhibiting the approach such as tyrosinase and anti-oxidation protection, with multicomponent multiple target effect
Thinking play Whitening, spot effect.Cooperate with multiple target effect specifically:
1. promoting blood recycles.Theory of traditional Chinese medical science thinks that the healthy colour of skin should be " white thin,tough silk wraps up in cinnabar ", i.e. " white touched with red ".When
Subcutaneous blood, which recycles unsmooth or insufficiency of vital energy and blood, will lead to dim complexion and pigmentation.Panoxadiol type saponin(e, the bletilla striata, Rhizoma Atractylodis Macrocephalae and
The extracts such as Radix Angelicae Sinensis can be effectively improved skin microcirculation, increase the erythrocyte number in unit time inner skin blood vessel, improve blood
Lactoferrin content makes skin become ruddy, furthermore the improvement of microcirculation, not only can be fibroblast and collagen egg in skin
It is white that sufficient nutrition is provided, the removing of various metabolites is also helped, skin metabolism is improved, improves the colour of skin.
2. reducing melanin production.The route of synthesis of melanin is it is found that inhibiting the activity of tyrosinase is to reduce black life
At effective means.The expression of p-p38 and p-JNK in MAPK signal path can be effectively suppressed in panoxadiol type saponin(e, up-regulation
The expression of p-ERK inhibits melanin production；Panoxadiol type saponin(e and bletilla striata extract can significantly lower tyrosinase, TRP -1
The expression of equal albumen, inhibits melanin production.
3. oxidation and removing free radicals.Ultraviolet light in daylight, which can induce, to be generated oxygen radical and then promotes TYR enzyme
Expression, promote melanin generate.The extracts such as Rhizoma Atractylodis Macrocephalae, the bletilla striata, Radix Angelicae Sinensis are remarkably improved DPPH radicals scavenging in the present invention
Rate；Rb1 and Rg1 in panoxadiol type saponin(e can substantially reduce the deposition of malondialdehyde (MDA), restore because of family
The horn cell that the irradiation of outer ultraviolet light (UVB) causes oxidation impaired, improves antioxidant activity, enhances skin self-regeneration and anti-ageing
Change effect.
4. nanosizing technique promotees to absorb.It joined emulsifier and assistant for emulsifying agent in the present invention, pass through component proportion and high pressure
The technique of homogeneous, is prepared oil-in-water type (O/W) Submicron Emulsion, and average grain diameter is less than 1000nm, polydispersity coefficient PDI < 0.2,
There is more preferable transdermal absorption factor compared with conventional emulsions, particle diameter distribution is uniform, good product stability, and preparation process is easy, is suitable for industry
Metaplasia produces.
Specific embodiment
The present invention provides a kind of composition and its application in the skin care item for preparing light speckles, beautification and white, those skilled in the art
Member can use for reference present disclosure, be suitably modified realization of process parameters.In particular, it should be pointed out that all similar substitutions and modifications
Apparent to those skilled in the art, they are considered as being included in the present invention.Method and application of the invention
Be described by preferred embodiment, related personnel obviously can not depart from the content of present invention, in spirit and scope it is right
Methods herein and application are modified or appropriate changes and combinations, carry out implementation and application the technology of the present invention.
The test material that the present invention uses is all common commercially available product, can all be bought in market.
Wherein, Rhizoma Atractylodis Macrocephalae extract is for the drying of compositae plant Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz.
The decocting of rhizome or alcohol reflux extract, extract method are ultrasonic extraction, and effective component is mainly atractylone, hinesol etc.
Volatile oil, atractylodes lactone, amino acid and polysaccharide component.
Bletilla striata extract is the dry tuber of orchid bletilla striata Bletilla striata (Thunb.) Reichb.f.
Decocting or alcohol reflux extract, extract method are ultrasonic extraction, and effective component is mainly bibenzyl, luxuriant and rich with fragrance class and its derivative
Object discusses volatile oil and polysaccharide, starch etc..
Angelica extract is the decocting of the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels
Or alcohol reflux extract, extract method are ultrasonic extraction, effective component is mainly that Ligustilide, butylidenephthalide etc. are waved
Hair oil, organic acid, polysaccharide and flavones ingredient.
Below with reference to embodiment, the present invention is further explained:
Embodiment 1
By panoxadiol type saponin(e 3g, arbutin 1g, Rhizoma Atractylodis Macrocephalae extract 3.5g, Cremophor RH40 3g, dehydrated alcohol
2g, trehalose 1.5g, glycerol 10g, 1,2 propylene glycol 5g, Phenoxyethanol 0.8g, which are added in 49.2g deionized water, to be dissolved, and must be combined
A；
Combination A is heated to 45 DEG C, stirring is to being completely dissolved；
5g saualane and the mixing of 3g coconut oil are preheated to 50 DEG C of mixing oil phase substrate；
Albiflorin 3.5g, oleanolic acid 2g, bletilla striata extract 4g, angelica extract 3.5g are dissolved in the miscella phase of preheating
In matrix, stirring is completely dissolved, and must combine B；
Combination A is added in B phase when being cooled to 40 DEG C, stir to two-phase mixtures, be placed in high pressure homogenizer 900bar homogeneous 10
Circulation, obtains homogeneous mutually soluble liquids；
Sodium citrate adjust pH to 6.5 to get；
It is 335nm, PDI < 0.1 that nano particle size instrument, which measures the compound average grain diameter,.
Embodiment 2
By panoxadiol type saponin(e 8.5g, arbutin 2.4g, Rhizoma Atractylodis Macrocephalae extract 2g, Cremophor RH603.5g, poly- second
- 400 3g of glycol, trehalose 2g, glycerol 8g, hyaluronic acid 5g, Phenoxyethanol 0.5g, which are added in 39.6g deionized water, to be dissolved, and is obtained
Combine A；
Combination A is heated to 50 DEG C, stirring is to being completely dissolved；
10g saualane and the mixing of 2g coconut oil are preheated to 55 DEG C of mixing oil phase substrate；
Albiflorin 3g, oleanolic acid 4g, bletilla striata extract 2.5g, angelica extract 4g are dissolved in the miscella phase base of preheating
In matter, stirring is completely dissolved, and must combine B；
Combination A is added in B phase when being cooled to 40 DEG C, stir to two-phase mixtures, be placed in high pressure homogenizer 500bar homogeneous 15
Circulation, obtains homogeneous mutually soluble liquids；
Sodium lactate adjust pH to 6.5 to get.
Embodiment 3
By panoxadiol type saponin(e 7g, Rhizoma Atractylodis Macrocephalae extract 6g, F68 5g, tween-80 1g, ethylene glycol 2.5g, pectin
1.5g, glycerol 6g, hexylene glycol 6g, Phenoxyethanol 0.5g, which are added in 33g deionized water, to be dissolved, and A must be combined；
Combination A is heated to 50 DEG C, stirring is to being completely dissolved；
9g saualane and the mixing of 3g coconut oil are preheated to 55 DEG C of mixing oil phase substrate；
Albiflorin 5g, oleanolic acid 5g, bletilla striata extract 5g, angelica extract 5.5g are dissolved in the miscella phase base of preheating
In matter, stirring is completely dissolved, and must combine B；
Combination A is added in B phase when being cooled to 40 DEG C, stir to two-phase mixtures, be placed in high pressure homogenizer 800bar homogeneous 12
Circulation, obtains homogeneous mutually soluble liquids；
Sodium citrate adjust pH to 6.5 to get.
Embodiment 4
By panoxadiol type saponin(e 5.5g, arbutin 6g, F68 3g, lecithin 2g, dehydrated alcohol 3g, Arabic gum
0.5g, pectin 1g, panthenol 1g, isopropyl palmitate 3g, Phenoxyethanol 0.8g, which are added in 46.7g deionized water, to be dissolved, and must be combined
A；
Combination A is heated to 45 DEG C, stirring is to being completely dissolved；
9g saualane and the mixing of 3g coconut oil are preheated to 50 DEG C of mixing oil phase substrate；
Albiflorin 6.5g, oleanolic acid 2.5g, bletilla striata extract 4g, angelica extract 2.5g are dissolved in the miscella of preheating
In phase matrix, stirring is completely dissolved, and must combine B；
Combination A is added in B phase when being cooled to 40 DEG C, stir to two-phase mixtures, be placed in high pressure homogenizer 600bar homogeneous 15
Circulation, obtains homogeneous mutually soluble liquids；
Newborn acid for adjusting pH to 6.5 to get.
Embodiment 5
Select 4 big ears of New Zealand white, example 1-4 is prepared gained whitening and answered by preserved skin using itself left and right sides method of comparison
The skin irritation test requirement that object is issued by National Laboratory Drug Administration is closed, reference preparation is sterile saline.
It is continuous to smear 2 weeks using same position multiple dosing mode, referring to skin wound repair standards of grading, pierced
Swash intensity evaluation.
The results show that 4 experimental animals occur without erythema, without oedema.Experimental group with compare cell mean without conspicuousness
Difference.Products obtained therefrom of the present invention is without skin irritation.
Embodiment 6
L-tyrosine, tyrosinase solution and phosphate buffer are prepared respectively, inhibit test (method referring to tyrosine activity
Referring to Chen Q X, Song K K, Wang Q, et al.Inhibitory effects of Mush-room Tyrosinase
by Some Alkylbenzaldehydes.Journal of Enzyme Inhibition and Medicinal
Chemistry, 2003,18 (6): 491-496) measure the tyrosinase inhibitor that Examples 1 to 4 prepares gained whitening compound
Rate.The results show that under same dosage, the inhibitory activity against tyrosinase of 1~No. 4 sample is followed successively by 36.4%, 33.2%,
27.3%, 24.5%.
Through statistical analysis:
The ability that Examples 1 and 2 resulting composition inhibits tyrosinase activity does not have significant difference；
The ability that the resulting composition of embodiment 3 and 4 inhibits tyrosinase activity does not have significant difference,
For embodiment 3 or 4, the composition of Examples 1 to 2, which has, more significantly to be inhibited tyrosinase activity
Ability (p < 0.05), it was demonstrated that gained whitening compound all has good tyrosinase activity inhibiting effect.
Embodiment 7
Select DPPH free radical scavenging activity measuring method (method referring to SEONG S.H., SEOG G.L., YONG C.,
et al.Antioxidant activity of crude extract and pure compounds of Acer
Ginnala Mix. [J] Bull Korean Chem Soc, 2001,25 (3): 389-391) evaluation Examples 1 to 4 preparation gained
The antioxidation in vitro performance of whitening compound.Make the result shows that same lower 4 samples of dosage all have good radicals scavenging
With Examples 1 to 4 sample free radical scavenging activity is followed successively by 39.5%, 38.2%, 28.4%, 30.6%.
Through statistical analysis, for embodiment 3 or 4, the tool of composition made from full constituent formulation Example 1~2
There is more significant radicals scavenging effect (p < 0.05).
The above is only the preferred embodiment of the present invention, it is noted that those skilled in the art are come
It says, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications also should be regarded as
Protection scope of the present invention.
Claims (10)
1. a kind of composition characterized by comprising ginsenoside, arbutin, albiflorin, oleanolic acid, Rhizoma Atractylodis Macrocephalae extract,
Bletilla striata extract and angelica extract.
2. composition according to claim 1, which is characterized in that be grouped as by the group of following mass parts:
3. composition according to claim 1 or 2, which is characterized in that the ginsenoside is ginseng diol type saponin(e.
4. the skin care item that the described in any item compositions of claims 1 to 3 are removed free radical, inhibited tyrosinase activity in preparation
In application.
5. a kind of skin care item of light speckles, beautification and white, which is characterized in that including the described in any item compositions of claims 1 to 3.
6. skin care item according to claim 5, which is characterized in that the mass fraction of the composition be 1.35%~
50%.
7. skin care item according to claim 5, which is characterized in that including following mass fraction:
8. skin care item according to claim 7, which is characterized in that
The emulsifier is Tween-80, lecithin, polyethylene glycol -600, soybean lecithin, polyethylene glycol Glycerin, mixed triester with caprylic acid capric acid, takes off
Water sorbitol sesquioleate, polyoxyethylene (40) rilanit special, polyoxyethylene (60) rilanit special, PLURONICS F87
At least one of (F68)；
The assistant for emulsifying agent is dehydrated alcohol, ethylene glycol, 1,2-PD, glycerine, polyethylene glycol -400, in polyglycerol ester extremely
Few one kind；
The thickening stabilizing agent be alginic acid, pectin, carbomer, sodium carboxymethylcellulose, Arabic gum, in tragacanth at least
It is a kind of；
The moisturizer be glycerine, butanediol, hexylene glycol, pentanediol, caprylic/capric triglyceride, sorbierite, urea, thoroughly
At least one of bright matter acid sodium, isopropyl palmitate, chondroitin sulfate, panthenol, polysaccharides.
9. skin care item according to claim 7 or 8, which is characterized in that further include preservative and pH adjusting agent；
Wherein preservative is Phenoxyethanol；
PH adjusting agent is selected from sodium citrate, sodium lactate or lactic acid；
The pH value of the skin care item is 6.5~6.8.
10. the preparation method of any one of claim 5~9 skin care item characterized by comprising
By ginsenoside, arbutin, Rhizoma Atractylodis Macrocephalae extract, emulsifier, assistant for emulsifying agent, thickener, moisturizer, preservative and deionization
Water mixing is heated to 40~50 DEG C of dissolutions, is A phase；
Saualane and coconut oil mixing are preheated to 50~55 DEG C of obtained oil phase substrate, albiflorin, oleanolic acid, the bletilla striata are mentioned
It takes object, angelica extract to be dissolved in the oil phase substrate, is B phase；
The B phase is cooled to 40 DEG C, is mixed with the A, high-pressure homogeneous 10~15 circulations, rear adjusting pH to 6.5~
6.8, the skin care item are made.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110755333A (en) * | 2019-12-03 | 2020-02-07 | 吉林省强参生物技术有限公司 | Composition and application thereof in preparing skin care product for preventing blue light and resisting aging |
| CN111557882A (en) * | 2020-07-02 | 2020-08-21 | 吉林省强参生物技术有限公司 | Composition and application thereof in preparing anti-aging skin care product |
| CN112957291A (en) * | 2021-02-19 | 2021-06-15 | 杭州市红十字会医院 | Skin-whitening and anti-aging skin-care composition |
| CN116056684A (en) * | 2020-07-30 | 2023-05-02 | 联合利华知识产权控股有限公司 | Personal care compositions comprising atractylenolide-I or a source of atractylenolide-I |
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| CN116056684A (en) * | 2020-07-30 | 2023-05-02 | 联合利华知识产权控股有限公司 | Personal care compositions comprising atractylenolide-I or a source of atractylenolide-I |
| CN112957291A (en) * | 2021-02-19 | 2021-06-15 | 杭州市红十字会医院 | Skin-whitening and anti-aging skin-care composition |
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