CN104490628A - Natural skin-whitening nourishing after-bath lotion and preparation method thereof - Google Patents
Natural skin-whitening nourishing after-bath lotion and preparation method thereof Download PDFInfo
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Abstract
The invention provides a natural skin-whitening nourishing after-bath lotion and a preparation method thereof. the natural skin-whitening nourishing after-bath lotion is prepared from the following raw materials in percentage by weight: 0.25-2.5 percent of ellagic acid, 0.03-0.3 percent of vitamin E, 0.025-0.25 percent of vitamin C, 0.03-0.3 percent of azelaic acid, 0.01-0.1 percent of ferulic acid, 0.5-1.0 percent of licoflavone, 2-8 percent of glycerinum, 1-6 percent of propylene glycol, 10-15 percent of lecithin, 0.02-3 percent of ethyl alcohol, 8-16 percent of tween-60, 2-5 percent of tween-80, 1-4 percent of polyoxyethylene sorbitan monooleate, 0.03-0.3 percent of essence and the balance of deionized water. The natural skin-whitening nourishing after-bath lotion is safe without irritation, can be used for effectively inhibiting the growth, the generation and the accumulation of skin melanin, removing stains and chloasma, and effectively preventing skin oxidation and repairing the problem skin, has good permeability, and is high in bioavailability.
Description
Technical field
The present invention relates to a emulsion and preparation method thereof, particularly a natural whiting nourishes rear emulsion of bath and preparation method thereof.
Background technology
In the season such as spring, autumn, winter of drying, under the impact in season, nutrient structure in skin can change, dry air also can fight for the moisture in skin, special skin has tension sensation after having a bath, and streaks meeting adularescent vestige, also can itch once in a while with fingernail, even also can play Rhizoma Euonymus, or occur dry and cracked situation.In the past, woman's skin protection often more focuses on " face-saving project ", but but extends to whole body skin from top to bottom now, and after bath, emulsion is the indispensable skin care item of female friend, and for easily dry position, the rear emulsion of bath can improve rapidly the situation of skin hydropenia.Consumption to be increased at positions such as cervical region, elbow, knee, ankles especially, give external moistening to skin, shower sensitivity can be alleviated and provocable skin.Along with growth in the living standard, people not only require to moisten moisturizing to emulsion after bath, more wish that it can add other effect, and emulsion is mostly moist moisturizing series products after bath in the market, and Nails is always U.S. with whitening skin, after therefore having natural whiting nourishing bath, the Study and Development of emulsion will have wide market prospect.
Summary of the invention
Main purpose of the present invention is for the deficiencies in the prior art, provides a kind of natural whiting to nourish the rear emulsion of bath.
For achieving the above object, the present invention adopts following technical scheme:
A kind of natural whiting nourishes the rear emulsion of bath, is prepared: 0.25-2.5% ellagic acid, 0.03-0.3% vitamin E by the raw material of following mass percentage content, 0.025-0.25% vitamin C, 0.03-0.3% azelaic acid, 0.01-0.1% ferulic acid, 0.5-1.0% licoflavone, 2-8% glycerol, 1-6% propylene glycol, 10-15% lecithin, 0.02-3% ethanol, 8-16% polysorbate60,2-5% Tween 80,1-4% polyoxyethylene monooleate, 0.03-0.3% essence, deionized water surplus.Each raw material components is commercially available prod above.
Preferably, a kind of natural whiting provided by the invention nourishes the rear emulsion of bath, prepared by the raw material of following mass percentage content: 0.5-2.0% ellagic acid, 0.1-0.25% vitamin E, 0.05-0.2% vitamin C, 0.05-0.25% azelaic acid, 0.025-0.075% ferulic acid, 0.6-0.8% licoflavone, 3-7% glycerol, 2-5% propylene glycol, 11-14% lecithin, 0.08-2% ethanol, 10-14% polysorbate60,3-4% Tween 80,2-3% polyoxyethylene monooleate, 0.05-0.25% essence, deionized water surplus.
More preferably, a kind of natural whiting provided by the invention nourishes the rear emulsion of bath, is prepared: 1% ellagic acid by the raw material of following mass percentage content, 0.18% vitamin E, 0.1% vitamin C, 0.15% azelaic acid, 0.05% ferulic acid, 0.7% licoflavone, 5% glycerol, 4% propylene glycol, 12% lecithin, 0.95% ethanol, 12% polysorbate60,3% Tween 80,2.5% polyoxyethylene monooleate, 0.15% essence, deionized water surplus.
Preferably, essence is wherein derived from plant essence, such as Fructus Citri Limoniae essence, lavandula angustifolia essence, rose essence, Mint Essence etc.
Preferably, vitamin E wherein, vitamin C are derived from extracted form natural plant and obtain.
The present invention also provides a kind of natural whiting to nourish the preparation method of the rear emulsion of bath, and the method includes the steps of:
(1) by 0.25-2.5% ellagic acid, 0.03-0.3% vitamin E, 0.025-0.25% vitamin C, 0.03-0.3% azelaic acid, 0.01-0.1% ferulic acid and the mixing of 0.5-1.0% licoflavone, add deionized water and 0.03-3% ethanol dissolves;
(2) by 10-15% lecithin heating for dissolving, by the mixing of above-mentioned solution wherein, then 2-8% glycerol is added, 1-6% propylene glycol, 8-16% polysorbate60,2-5% Tween 80 and 1-4% polyoxyethylene monooleate mix and blend;
(3) then add 0.03-0.3% essence, and supply residue deionized water, pour 100mpa in high pressure homogenizer into, carry out high pressure homogenizing, take out after emulsion is extremely transparent, cooling, obtain whitening and nourish the rear emulsion of bath.
The comprehensive active substance at utmost retaining each composition, and the simplicity of processing technique, the consideration of cost control each side, preferably, in step (1), mixing carries out in the temperature range of 15-25 DEG C, more preferably at room temperature carries out.
Preferably, in step (1), the amount adding deionized water accounts for the 5-15% of the total consumption of ionized water, most preferably accounts for 10%.
Preferably, in step (1), ethanol used is industrial alcohol, more preferably uses food stage ethanol.
Preferably, in step (2), lecithin is heated to 30-60 DEG C of dissolving, is more preferably heated to 35-55 DEG C and dissolves, most preferably dissolve at 50 DEG C, too high, can destroy its effective ingredient, the too low then solute effect of temperature is very poor.
Preferably, in step (3), carry out high pressure homogenize being greater than under 1.5 atmospheric conditions, be preferably greater than 2 atmospheric pressure, most preferably under 2 atmospheric conditions, carry out high pressure homogenize.
In formula of the present invention, with the addition of nucleus ellagic acid, ellagic acid is a kind of natural polyphenol component be extensively present in various plant tissue, is extensively present in nature various plants and fruit.For skin whitening, restraint of tyrosinase is active, blocks melanin and generates, and has the effect of antioxidation, whitening and light speckle; Also can avoid external injury by available protecting.
Azelaic acid has potent antibacterial sterilizing function, and has the smooth skin effect of whitening, energy pore refining, and eliminate pox scar pox print, treatment acne, effectively nurse one's health sebaceous gland excessive secretion.
Ferulic acid has effect that is vigorous and graceful and protection skin, has stronger antioxidant activity, has protective effect to DNA.
The activity of licoflavone energy restraint of tyrosinase, can suppress again dopachrome change and the oxidasic activity of DHICA, also can scavenging activated oxygen, to skin, the nutritious moisture-keeping function of hair, and has repair to the skin of damage, hair.
Vitamin E is antioxidant, and free radical resisting is oxidized, can effectively to free radical resisting, LPO inhibitor, eliminating chloasma; The activity of restraint of tyrosinase, thus reduce melanin generation; Eliminate the too much oxygen-derived free radicals caused by the extraneous factor such as ultraviolet, air pollution, play and delay photoaging, prevention sunburn and suppress the effects such as sunburn generation.
Vitamin C is antioxidant, and protection health avoids the threat of free radical, for antibody and collagen are formed; tissue repairing, the metabolism of phenylalanine, tyrosine, folic acid, the utilization of ferrum, carbohydrate; the synthesis of fat, protein, maintains immunologic function, hydroxylation and hydroxytryptamine; keep the complete of blood vessel, promote that the institutes such as nonheme iron absorption are required, also have antioxidation simultaneously; free radical resisting; the formation of restraint of tyrosinase, thus reach whitening, effect of light speckle.
Glycerol, propylene glycol then contribute good water conservation, moisturizing and dilution, dispersion effect in formula of the present invention.Lecithin, ethanol, polysorbate60, Tween 80, stable, dispersed, ductility that polyoxyethylene monooleate is then system play extraordinary contribution, and the use of said components, by realizing the equiprobable mechanism of better osmotic effect, creates the effect of Synergistic between each component of emulsion after making whitening of the present invention nourish bath.
Compared with prior art, after the natural whiting prepared by the present invention nourishes bath, emulsion has following beneficial effect:
1, functional component of the present invention all derives from Chinese medicine extract, natural, and safety is non-stimulated, reduces irritated incidence rate, and has good protective effect to responsive skin;
2, emulsion whitening effect of the present invention is good, and have the growth effectively suppressing dermal melanin, the generation of check melanin and the beneficial effect of accumulation, have good result to skin-whitening;
3, there is excellent antioxidant characteristic, effectively can prevent skin oxidative and repair problem skin;
4, mottle and chloasma are had to good desalination, remove effect;
5, there is excellent water-retaining property, effectively prevent skin from chapping, keratinization, the problems such as the drying of skin can be prevented;
6, the red swelling of the skin caused allergy, keratinization have certain repairing effect;
7, by whitening, nourishing composition and the compatibility repairing composition, penetration enhancement composition, synergistic function is served between each composition, each component for skin permeability is better, active substance utilization rate is higher, effective ingredient has powerful permeability, may penetrate into atomic little space, and nutrient can rapidly by skin efficient absorption, can be used for the reparation of skin after taking a shower, and there is the multi-efficiencies such as natural whiting effect.
Detailed description of the invention
Following examples further illustrate content of the present invention, but should not be construed as limitation of the present invention.Without departing from the spirit and substance of the case in the present invention, the amendment do the inventive method, step or condition or replacement, all belong to scope of the present invention.
If do not specialize, the conventional means that technological means used in embodiment is well known to those skilled in the art, raw material used in embodiment is commercially available, wherein ellagic acid, vitamin E, vitamin C, azelaic acid, ferulic acid, licoflavone, glycerol, propylene glycol, lecithin, ethanol, polysorbate60, Tween 80, polyoxyethylene monooleate, essence, deionized water is commercially available obtaining, and described in be producer by conventional method extract obtain.
Embodiment 1
Whitening nourish bath after emulsion components and mass percentage content as follows: 1g ellagic acid, 0.18g vitamin E, 0.1g vitamin C, 0.15g azelaic acid, 0.05g ferulic acid, 0.7g licoflavone, 5g glycerol, 4g propylene glycol, 12g lecithin, 0.95g ethanol, 12g polysorbate60,3g Tween 80,2.5g polyoxyethylene monooleate, 0.15g essence, deionized water 58.22g.
Concrete preparation method is as follows: first, by the ellagic acid of above-mentioned formula, and vitamin E, vitamin C, azelaic acid, ferulic acid and licoflavone mixing, add deionized water and ethanol dissolves; Then, lecithin is heated to 50 DEG C of dissolvings, by the mixing of above-mentioned solution wherein, then adds glycerol, propylene glycol, polysorbate60, Tween 80 and polyoxyethylene monooleate mix and blend; Finally add essence (mint aroma), and supply residue deionized water, pour 100mpa in high pressure homogenizer into, carry out high pressure homogenizing, take out after emulsion is extremely transparent, cooling, obtain whitening and nourish the rear liposome emulsion of bath.
Embodiment 2
In the present embodiment natural whiting nourish bath after emulsion components and mass percentage content as follows: 2.0g ellagic acid, 0.1g vitamin E, 0.2g vitamin C, 0.05g azelaic acid, 0.075g ferulic acid, 0.6g licoflavone, 7g glycerol, 2g propylene glycol, 14g lecithin, 0.08g ethanol, 14g polysorbate60,3g Tween 80,3g polyoxyethylene monooleate, 0.05g essence, deionized water 53.845g, its preparation method is with embodiment 1.
Embodiment 3
Under in the present embodiment, natural whiting nourishes the rear emulsion components of bath and mass percentage content: 0.5g ellagic acid, 0.25g vitamin E, 0.05g vitamin C, 0.25g azelaic acid, 0.025g ferulic acid, 0.8g licoflavone, 3g glycerol, 5g propylene glycol, 11g lecithin, 2g ethanol, 10g polysorbate60,4g Tween 80,2g polyoxyethylene monooleate, 0.25g essence, deionized water 60.875g, its preparation method is with embodiment 1.
Embodiment 4 whitening effect is tested
1, experiment in vitro
The rear emulsion of bath is nourished in the whitening that laboratory sample: A1-A3 is respectively embodiment 1-3; B1: matched group 1 (the rear emulsion of bath is nourished in commercially available whitening); B2: matched group 2 (2% hydroquinone cream); B3 matched group 3 (deionized water).
Experimental cell: people source epidermal melanocytes
Experimental technique: after getting 1mg each sample deionized water dissolving, with sample injector, sample liquid being added growth has in the aperture of the Tissue Culture Plate of adherent melanocyte, be placed in incubator to cultivate, after 3 days, counting cells number is to judge the inhibition of sample to melanocyte.
Evaluation index: the inhibition grown melanocyte with 100 points of full marks evaluations, 0 is divided into unrestraint, and more than 60 points is significant effective suppression, and experimental result is as table 1.
The rear external whitening effect of emulsion of bath is nourished in table 1 whitening of the present invention
| Sample | To the inhibition of melanocyte growth |
| A1 | 86 |
| A2 | 83 |
| A3 | 82 |
| B1 | 75 |
| B2 | 90 |
| B3 | 0 |
After test result shows the obtained whitening nourishing bath of the embodiment of the present application 1-3, emulsion check melanin Growth of Cells is obvious, can the generation of effective check melanin, and emulsion suppresses not obvious to melanocyte after commercially available whitening bath, after natural whiting of the present invention nourishing bath is described, emulsion has obvious white-skinned face function; Deionized water does not in contrast have white-skinned face function; Whitening effect is it is preferred that hydroquinone, but hydroquinone has very large hazardness to human body, is forbidden for cosmetics by European Union.
2, human body whitening and speckle dispelling test
Laboratory sample: A1: the rear emulsion of bath is nourished in the whitening of embodiment 1; A2: the rear emulsion of bath is nourished in the whitening of embodiment 2; A3: the rear emulsion of bath is nourished in the whitening of embodiment 3; B1: matched group 1 (the rear emulsion of bath is nourished in commercially available whitening); B2:(deionized water).
Experimental procedure: select 10 experimenters, be divided into 5 groups, observes skin color, gloss, uses above-mentioned five groups of samples respectively, continues 7 days, observes skin color, gloss giving a mark.
Evaluation index: whether whitening evaluation index comprises whitening skin degree and improve, and whether mottle, chloasma have desalination etc., comprehensively improve index with 100 points of full marks evaluations, experimental result is as table 2.
Table 2 whitening effect is tested
| Sample | Evaluation result (full marks 100 points) |
| A1 | 95 |
| A2 | 91 |
| A3 | 90 |
| B1 | 81 |
| B2 | 45 |
Can find out discovery from experimental result, compare with the commercially available prod of matched group, the whitening of the application is nourished the whitening and speckle dispelling effect of bathing rear emulsion and is obtained remarkable improvement.
Embodiment 5 antiallergic is tested
1, zoopery
Cutaneous Anaphylaxis model is set up: after 7%DNGB acetone soln sensitization 2 weeks, and with 0.1%DNGB (1 week 1 time, continue 4 weeks) for Cavia porcellus ear sensitization, after the 48h at every turn excited, local swelling is reacted.Complete after exciting 48h and can be observed incrustation, the visible hyperplasia of dermal pathology after 72h, skin keratin.
Antiallergic test procedure:
Emulsion (A1-A3) after the whitening nourishing bath that test specimen: embodiment 1-3 is obtained, matched group 2 groups, is respectively commercially available whitening and nourishes the rear emulsion (B1) of bath and deionized water (B2).
Every 12h smears Cutaneous Anaphylaxis model Cavia porcellus ear's allergic skin affected part, one day twice, totally 3 days, observed result.Result display is as table 3.
The zoopery of table 3 antiallergic
| Sample | Result |
| A1 | Illing skin symptom is alleviated as seen |
| A2 | Illing skin symptom is alleviated as seen |
| A3 | Illing skin symptom is alleviated as seen |
| B1 | Illing skin symptom is slightly alleviated |
| B2 | Illing skin symptom is slightly alleviated |
2, human experimentation
Emulsion (containing effective ingredient) after the whitening nourishing bath that laboratory sample: A: embodiment 1-3 is obtained,
Experimental procedure: scalp sample being acted on respectively experimenter's (tested number 50), and skin of neck and hard of hearing skin, after 10 minutes, observe the skin of experimenter, experimental result is as table 4.
The zoopery of table 4 antiallergic
| Sample | Scalp | Skin of neck | Ear's skin |
| A1 | Without anaphylaxis | Without anaphylaxis | Without anaphylaxis |
| A2 | Without anaphylaxis | Without anaphylaxis | Without anaphylaxis |
| A3 | Without anaphylaxis | Without anaphylaxis | Without anaphylaxis |
Go out from the experimental results, the rear emulsion of bath is nourished in whitening of the present invention, and natural gentleness is non-stimulated to skin, uses completely reliable.
Embodiment 6 ductility test
After natural whiting nourishes bath, emulsion skin ductility is tested
Emulsion (A1-A3) after the whitening nourishing bath that test sample: embodiment 1-3 is obtained, emulsion (B1) after commercially available bath.
Method of testing: spread upon respectively on plastic plate by sample, smear their ductility of test with finger, emulsion extends apart from longer, proves that its quality is salubriouser, easily absorbs.
Test result shows, and the whitening of three groups of embodiment 1-3 is nourished the rear emulsion of bath and extended distance all than the obvious length of matched group, illustrates that its quality is salubriouser, easily absorbs.
From effect test, Beauty of Product white effect of the present invention is better, although whitening effect scoring is slightly lower than hydroquinone, but in view of hydroquinone due to toxic and side effects forbid by various countries using in cosmetics, product of the present invention then has good safety, in general, product of the present invention is emulsion after a kind of natural whiting nourishing bath of excellence.
Although above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (4)
1. natural whiting nourishes the rear emulsion of bath, is prepared: 0.25-2.5% ellagic acid, 0.03-0.3% vitamin E by the raw material of following mass percentage content, 0.025-0.25% vitamin C, 0.03-0.3% azelaic acid, 0.01-0.1% ferulic acid, 0.5-1.0% licoflavone, 2-8% glycerol, 1-6% propylene glycol, 10-15% lecithin, 0.02-3% ethanol, 8-16% polysorbate60,2-5% Tween 80,1-4% polyoxyethylene monooleate, 0.03-0.3% essence, deionized water surplus.
2. natural whiting according to claim 1 nourishes the rear emulsion of bath, it is characterized in that, prepared by the raw material of following mass percentage content: 0.5-2.0% ellagic acid, 0.1-0.25% vitamin E, 0.05-0.2% vitamin C, 0.05-0.25% azelaic acid, 0.025-0.075% ferulic acid, 0.6-0.8% licoflavone, 3-7% glycerol, 2-5% propylene glycol, 11-14% lecithin, 0.08-2% ethanol, 10-14% polysorbate60,3-4% Tween 80,2-3% polyoxyethylene monooleate, 0.05-0.25% essence, deionized water surplus.
3. natural whiting according to claim 1 nourishes the rear emulsion of bath, it is characterized in that, is prepared: 1% ellagic acid by the raw material of following mass percentage content, 0.18% vitamin E, 0.1% vitamin C, 0.15% azelaic acid, 0.05% ferulic acid, 0.7% licoflavone, 5% glycerol, 4% propylene glycol, 12% lecithin, 0.95% ethanol, 12% polysorbate60,3% Tween 80,2.5% polyoxyethylene monooleate, 0.15% essence, deionized water surplus.
4. prepare the method that the arbitrary described natural whiting of claim 1-3 nourishes the rear emulsion of bath, comprise the following steps:
(1) by the ellagic acid of described content proportioning, vitamin E, vitamin C, azelaic acid, ferulic acid and licoflavone mixing, add deionized water and ethanol dissolves;
(2) by the lecithin heating for dissolving of described content proportioning, by the mixing of above-mentioned solution wherein, then the glycerol of described content proportioning is added, propylene glycol, polysorbate60, Tween 80 and polyoxyethylene monooleate mix and blend;
(3) then add essence, and supply residue deionized water, pour 100mpa in high pressure homogenizer into, carry out high pressure homogenizing, take out after emulsion is extremely transparent, cooling, obtain whitening and nourish the rear emulsion of bath.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104825382A (en) * | 2015-05-26 | 2015-08-12 | 成都肤格特商贸有限公司 | Biotechnology skin-whitening cosmetics |
| CN107440996A (en) * | 2017-09-04 | 2017-12-08 | 山东美貌化妆品股份有限公司 | A kind of skin care item containing B B-complex and preparation method thereof |
| CN107854328A (en) * | 2017-10-16 | 2018-03-30 | 上海怡硕净化科技有限公司 | A kind of PA4 efficiently highlights skin care item |
| CN108542819A (en) * | 2018-05-25 | 2018-09-18 | 深圳市佑惑生物科技有限公司 | A kind of biology skin lightening facial mask liquid and preparation method thereof |
| CN109044871A (en) * | 2018-10-19 | 2018-12-21 | 湖南御家化妆品制造有限公司 | A kind of composition and its preparing the application in antioxidation cosmetic product |
| CN109793684A (en) * | 2019-03-22 | 2019-05-24 | 云南省农业科学院花卉研究所 | A kind of face cream and preparation method thereof |
| CN112237560A (en) * | 2020-10-28 | 2021-01-19 | 广州品赫化妆品有限公司 | Whitening composition containing emblic leafflower fruits and application thereof |
| CN114869795A (en) * | 2022-03-29 | 2022-08-09 | 上海肤徕生物高科技有限公司 | Preparation method of whitening composition for improving solubility of active components, product and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104825382A (en) * | 2015-05-26 | 2015-08-12 | 成都肤格特商贸有限公司 | Biotechnology skin-whitening cosmetics |
| CN107440996A (en) * | 2017-09-04 | 2017-12-08 | 山东美貌化妆品股份有限公司 | A kind of skin care item containing B B-complex and preparation method thereof |
| CN107854328A (en) * | 2017-10-16 | 2018-03-30 | 上海怡硕净化科技有限公司 | A kind of PA4 efficiently highlights skin care item |
| CN108542819A (en) * | 2018-05-25 | 2018-09-18 | 深圳市佑惑生物科技有限公司 | A kind of biology skin lightening facial mask liquid and preparation method thereof |
| CN109044871A (en) * | 2018-10-19 | 2018-12-21 | 湖南御家化妆品制造有限公司 | A kind of composition and its preparing the application in antioxidation cosmetic product |
| CN109044871B (en) * | 2018-10-19 | 2021-08-17 | 湖南御家化妆品制造有限公司 | Composition and application thereof in preparation of antioxidant cosmetics |
| CN109793684A (en) * | 2019-03-22 | 2019-05-24 | 云南省农业科学院花卉研究所 | A kind of face cream and preparation method thereof |
| CN112237560A (en) * | 2020-10-28 | 2021-01-19 | 广州品赫化妆品有限公司 | Whitening composition containing emblic leafflower fruits and application thereof |
| CN114869795A (en) * | 2022-03-29 | 2022-08-09 | 上海肤徕生物高科技有限公司 | Preparation method of whitening composition for improving solubility of active components, product and application thereof |
| CN114869795B (en) * | 2022-03-29 | 2024-01-26 | 上海肤徕生物高科技有限公司 | Preparation method of whitening composition, product and application thereof |
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Application publication date: 20150408 |