CN106265134B - Essence and preparation method thereof is repaired in a kind of polypeptide whitening - Google Patents
Essence and preparation method thereof is repaired in a kind of polypeptide whitening Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Abstract
The invention discloses a kind of polypeptide whitenings to repair Essence cosmetics and preparation method thereof, the cosmetics are rich in beauty polypeptide moiety, mainly include following components: hexapeptide -10, tridecanoic peptide -1, carnosine, vitamin C, vitamin E, propylene glycol, glycerol, allantoin, laureth -23, Phenoxyethanol, triethanolamine, ferulic acid, panthenol, hyaluronic acid.Hexapeptide -10, tridecanoic peptide -1, three kinds of beauty polypeptides of carnosine total weight percent 15~30%.Three kinds of beauty polypeptides of the Essence are the important nutritional ingredient of skin and the main functional component of the product.Some researches show that the additions of three kinds of polypeptide moieties can be obviously promoted skin cell proliferation, function that is anti-oxidant and removing free radical, is finally reached the function of repairing skin.
Description
Technical field
The present invention relates to cosmetic fields, and in particular to Essence and preparation method thereof is repaired in a kind of polypeptide whitening.
Background technique
With the development of economy, work, rhythm of life are getting faster, and stress is increasing, in addition undesirable life
Injury of many factors such as habit, adverse circumstances, ultraviolet light, incorrect skin nursing to skin, more and more people all by
It is dry, coarse, do not have elasticity, dim mute, the whole face look tired of the colour of skin, the skins disorder such as coarse, pore is coarse synthtic price index puzzlement,
Although skin care item in the market are very rich, in face of this global question always can not very good solution, usually solution is never
?.
Contain 4%~5% chromatophore in the basal layer cell of human epidermal.The color of human skin is not depend on black
Chromatophore quantity, but depend on quantity, size, distribution and the melanocyte degree of melanosome.Therefore, some whitening compositions
Achieve the effect that whitening by influencing formation, maturation and the transfer of melanosome.
Polypeptide is amino acid composition (50 amino acid hereinafter referred to as polypeptide, 50 amino acid are referred above to albumen), is egg
The intermediate hydrolysate of white matter and the constituent of human body cell.A large number of studies show that not fully water after protein intake
Solution is absorbed in the form of peptide at amino acid, major part, also found simultaneously, amino of the absorbed speed of polypeptide than same composition
Acid is fast.
Polypeptide is mainly endogenous polypeptide or other natural polypeptides, and structure understands, mechanism of action is clear, and quality controls water
It flushes and is bordering on traditional small molecule chemicals, and close to albumen in activity, gathered the excellent of conventional chemicals and albumen
Point.
Polypeptide is protein fragments, and structure is widely present in animal and plant body between amino acid and protein, is adjusted
Save the balance of body.Peptide is the source for studying origin of life, structure function and disease, for studying the cell and tissue of the mankind
Aging, death process is very helpful.
Beauty polypeptide is a kind of polypeptide with beauty functions.The condensation product being made of multiple amino acid is (common at present
Beauty polypeptide is 2-10 amino condensation compound), but because amino acid classes, sequence are different, function is entirely different.
Beauty polypeptide because not injured to human body, effect is obvious, mechanism of action is clear, foreign countries applied more than 20
Year, many big shot products all addition (Estee Lauder, it is fragrant how, Christian Dior, Lancome etc.), and China just starts to walk, and market is answered
Dosage is also seldom, and many products are also all to propagandize；But as State Food and Drug Administration supervises gradually cosmetics
Reinforce, market is bound to gradually standardize.
Beauty polypeptide is because being related to molecular biology, and biochemistry, genetic science, Dermatology and cosmetic science etc. are more
Subject needs long-term, basic and microcosmic in-depth study, while needing to establish complete, accurate appraisement system, so
The application beauty polypeptide that Cosmetics in China market wants extensive, deep also needs a process.
Nearly 400,000,000,000 yuan of China cosmetic retail transaction scale (containing personal care product) in 2015, and be in go up year by year
Trend, annual growth are stablized 8% or so.Since domestic beauty polypeptide is using at the early-stage, and the following beauty polypeptide
Using the trend that will also become cosmetic industry, increase so beauty polypeptide skin care item can become a strength in future
Point.
Summary of the invention
The present invention has comprehensively considered the various factors for causing skin injury and forming melanin, one object of the present invention
It is to propose that Essence is repaired in a kind of polypeptide whitening.The polypeptide whitening repairs Essence using a variety of beauty polypeptides as chief active
Ingredient plays synergistic effect, repairs cell in damaged condition, promotes neonatal cell proliferation, and inhibit the formation of melanin, finally reaches
To the effect of skin whitening.
The present invention to achieve the goals above, using following technical scheme:
A kind of polypeptide whitening reparation Essence cosmetics, weight percentage, including following components:
Preferably, the composition is by mass percentage, including component below:
Preferably, the composition is by mass percentage, including component below:
As further preferably, the hexapeptide -10, tridecanoic peptide -1, three kinds of beauty polypeptides of carnosine total weight percent 15
~20%.
As further preferably, the hexapeptide -10, tridecanoic peptide -1, three kinds of beauty polypeptides of carnosine purity in 95-99%.
Mentioned component of the present invention can be bought on the market, belong to existing product.
Another object of the present invention is to provide the preparation method that Essence cosmetics are repaired in polypeptide whitening.
In order to realize above-mentioned second purpose, using following technical scheme:
The preparation method of Essence cosmetics is repaired in a kind of polypeptide whitening, comprising the following steps:
1) by water, glycerol, propylene glycol, vitamin C, vitamin E, ferulic acid, panthenol and hyaluronic acid, allantoin and laurel
Alcohol polyethers -23 is added in reactor tank, opens stirring, is heated to 75~80 DEG C, is dispersed with stirring uniformly；
2) cooling circulating water is opened, Phenoxyethanol, triethanolamine are added when temperature is down to 45~50 DEG C for stirring cooling
In reactor tank, homogeneous 1 minute, stirring and dissolving was complete；
3) continue stirring to be cooled to lower than 37 DEG C, hexapeptide -10, tridecanoic peptide -1, carnosine are added in reactor tank, homogeneous 2-3
Minute, stirring and dissolving is complete, terminates.
In the present invention, three kinds of beauty polypeptides and injection Vitamin B_6 are main additive.Wherein:
Hexapeptide -10 is a kind of beauty polypeptide synthesized using solid-phase synthesis, its main feature is that with high purity, stingless to human body
Swash, beauty clear mechanism, Argireline can promote damaged cell regeneration, and promote the synthesis of laminin V[1]。
Tridecanoic peptide -1 is a kind of beauty polypeptide synthesized using solid-phase synthesis, its main feature is that with high purity, stingless to human body
Swash, beauty clear mechanism, tridecanoic peptide -1 is a kind of skin conditioner, has good whitening, anti-wrinkle effect[2]。
Carnosine is a kind of beauty polypeptide synthesized using solid-phase synthesis, its main feature is that with high purity, non-stimulated to human body, beautiful
Hold clear mechanism, carnosine has very strong inoxidizability[3], to reduce injury of the oxygen radical to skin, long-time service can be with
It is apparent to inhibit thinning of skin and flexibility decrease, slow down the formation of wrinkle, and there are also repairs to some damages.It is different dense
It is different to Hydroxyl radical-scavenging ability to spend carnosine[4,5], strong free radical ability is removed in concentration increase to be enhanced.10% carnosine is to hydroxyl freedom
Base inhibiting rate reaches 60%.
Vitamin C can restrain chromoplast deposition, not only can effectively prevent blackspot and freckle, moreover it is possible to by extra color
Element excretes, and thoroughly improves the low and deep colour of skin, and enabling skin again becomes pale bright.
Vitamin E has antioxidation, to protect the moisture in sebum and cell membrane protein and skin.It is also
Regeneration and the vigor that can promote human body cell, postpone the ageing process of cell.
It is another object of the present invention to provide the applications that Essence is repaired in polypeptide whitening.
Polypeptide whitening of the present invention repairs Essence and repairs cell in damaged condition in preparation, promotes neonatal cell proliferation,
Inhibit the formation of melanin, the application in the product of skin whitening.Polypeptide whitening of the present invention is repaired Essence and is being prepared
It prevents wrinkle of skin from generating, slows down skin aging, reduce the application in the product that skin lines generate.
Product of the present invention has the advantages that for existing product
1) for aging and skin tired out, it is apparent that aging phenomenon slows down after use, and skin surface it
Microgroove is also reduced.It prevents wrinkle from generating, and skin is made to seem smooth, delicate, soft.
2) damage skin can be made to become more smooth, beautiful white in a short time.
3) it will form a fine film in cortical surface, make it have apparent firming effect, compared with other products, make
With more rapid.After continuous use 14 days, skin damage rate can reduce by 40%, and wrinkle depth can reduce 25%.
Detailed description of the invention
Fig. 1: the situation of change of recipient site melanin content during polypeptide whitening reparation Essence use
Fig. 2: the variation diagram 3:MEXAMETER MXl8 skin of recipient site L* value during polypeptide whitening reparation Essence use
Colour of skin element instrument
Fig. 4: coloration spectrophotometer
Specific embodiment
By following specific embodiments, the present invention is further illustrated, but not as limitation of the invention.
Embodiment 1
Essence is repaired in polypeptide whitening:
The recipe ingredient and weight percentage of Essence are as follows:
| Ascoltin (vitamin C) | 8% |
| Propylene glycol | 3% |
| Glycerol | 3% |
| Allantoin | 0.1% |
| Laureth -23 | 0.5% |
| Alpha-tocopherol (vitamin E) | 1% |
| Phenoxyethanol | 0.2% |
| Triethanolamine | 0.3% |
| Ferulic acid | 0.5% |
| Panthenol | 0.8% |
| Hyaluronic acid | 2% |
| Hexapeptide -10 | 5% |
| Tridecanoic peptide -1 | 5% |
| Carnosine | 5% |
| Water | Surplus |
The preparation method of aforementioned polypeptides whitening reparation Essence, including the following steps: by water, glycerol, propylene glycol, vitamin
C, vitamin E, ferulic acid, panthenol and hyaluronic acid, allantoin and laureth -23 are added in reactor tank, open stirring,
75~80 DEG C are heated to, is dispersed with stirring uniformly；Open cooling circulating water, stirring cooling, when temperature is down to 45~50 DEG C, by benzene
Oxyethanol, triethanolamine are added in reactor tank, and homogeneous 1 minute, stirring and dissolving was complete；Continue stirring to be cooled to lower than 37 DEG C, it will
Hexapeptide -10, tridecanoic peptide -1, carnosine be added reactor tank in, homogeneous 2-3 minutes, stirring and dissolving completely to get.
Embodiment 2- embodiment 5
It is as follows that Essence cosmetics, each component weight percent of embodiment 2- embodiment 5 are repaired in polypeptide whitening:
The preparation method of aforementioned polypeptides whitening reparation Essence, including the following steps: by water, glycerol, propylene glycol, vitamin
C, vitamin E, ferulic acid, panthenol and hyaluronic acid, allantoin and laureth -23 are added in reactor tank, open stirring,
73~78 DEG C are heated to, is dispersed with stirring uniformly；Open cooling circulating water, stirring cooling, when temperature is down to 43~48 DEG C, by benzene
Oxyethanol, triethanolamine are added in reactor tank, and homogeneous 1 minute, stirring and dissolving was complete；Continue stirring to be cooled to lower than 37 DEG C, it will
Hexapeptide -10, tridecanoic peptide -1, carnosine be added reactor tank in, homogeneous 2-3 minutes, stirring and dissolving completely to get.
Essence is repaired in embodiment 6, polypeptide whitening
Essence of the invention, consists of the following compositions:
Essence is repaired in embodiment 7, polypeptide whitening
Essence of the invention, consists of the following compositions:
Essence is repaired in embodiment 8, polypeptide whitening
Essence of the invention, consists of the following compositions:
Essence is repaired in embodiment 9, polypeptide whitening
Essence of the invention, consists of the following compositions:
Experimental example 1
The test of product of the present invention Performance Evaluation is as follows:
One, skin irritation test:
2.5~3kg healthy rabbits 20 are selected, every rabbit back bilateral symmetry selects shaving 3cm at 102, with own control
Test method(s) carries out, and applies 0.5g product of the present invention every time, twice daily, the tested material is given in left or right side at random, observes and records
For 24 hours, after 72h skin reacting phenomenon.
The result shows that: it applies product of the present invention and has no that the local stimulations such as rubefaction, dermexanthesis, water lump are reacted for 24 hours, after 72h, say
It is a safe, non-stimulated, without any adverse reactions product that Essence is repaired in bright polypeptide whitening of the present invention.
Two, efficacy validation of the present invention:
50 volunteers are chosen, are divided into 5 groups, every group of 10 people.Female age in 23-50 one full year of life, face have due to solarization,
Facial lesion caused by dark sore, the stimulation of water laser accunputure etc..Product acts on cheek, once in the morning and once at night, is used continuously one month.
Facial repairing effect description:
Be obviously improved: facial deep lesions are unobvious, and slight damage is obviously reduced, is thin out, and the whole colour of skin obviously highlights；
Moderate improves: facial deep lesions mitigate, and slight damage reduces, the whole colour of skin is highlighted；
Without improvement: indifference before and after use.
As a result: in 50, significantly accounting for 78% using product of the present invention effect, what moderate improved accounts for 22%, in total effectively
Rate is 100%, and whole subjects adverse reaction occur without an example.
Three, clinical evaluation is carried out to 1 Whitening, spot effect of embodiment
The polypeptide whitening provided in this experimental selection embodiment 1 is repaired Essence and is tested.
It selects 30 ages in 23~50 years old healthy women, measures the pigment content and skin color of its cheek, then send out
Put tested cosmetics.Study subject is used continuously polypeptide whitening and repairs Essence sample.The left and right cheek portion of tester, compares
Experiment respectively uses 1 time, application after face cleaning sooner or later daily.Other skin-lightening cosmetics are deactivated during the experiment.Continuous use 7d,
After 14d, 21d, 30d, then measure each efficacy measures.Inquire volunteer using feeling after given the test agent and whether there is or not allergy simultaneously
Phenomenon etc. records itself front and back comparison.Lab coloration system is being utilized using the preceding 1d of cosmetics and using rear 7d, 14d, 21d, 30d
Spectrophotometer of uniting measures the variation of skin color, follow-on test 3 times, is averaged.MEXAMETER MXl8 skin is used simultaneously
Colour of skin element instrument surveys dermal melanin content, follow-on test 3 times, is averaged.Data processing uses sigmastat statistical software
Paired t-test is carried out, there is significant meaning with P < 0.05.
The situation of change of test front and back recipient site dermal melanin content: 30 study subjects of this experiment are equal to sample
There is good tolerance, has no adverse reaction.(data are shown in Table 1) as shown in Figure 1, experimental group using 7d, 14d after sample,
The melanin content of 21d, 30d are before use compared to reduction (P < 0.05).
The situation of change of recipient site melanin content during 1 polypeptide whitening of table reparation Essence use
The situation of change of test front and back recipient site skin coloration L* value: skin coloration L* value is bigger, indicates skin color
It is more shallow.7d after product use, skin coloration L* value just has increased trend, since 14d, is just significantly greater than before testing
Horizontal (P < 0.05) (see Fig. 2,2) data are shown in Table, and the trend gradually increased is presented with the extension of product use time in L* value.
The variation of recipient site L* value during 2 polypeptide whitening of table reparation Essence use
In conclusion the whitening product has significant white-skinned face function, that is, there is bright color and lighten the stain dual
Effect.
In order to save length, the present invention only enumerates the experimental result of section Example, matches substantially in accordance with of the invention
The product just prepared has same or similar beneficial effect with above-described embodiment.
Experimental example 2
Essence stability test result is repaired in polypeptide whitening
Made contain 5% hexapeptide-10,5%0 according to 2660-2004 pairs of QB/T of People's Republic of China's light industry standard
The polypeptide whitening of tripeptides -1,5% carnosine repairs Essence and carries out sense organ, physicochemical property test, and the results are shown in Table 3.It can by table 3
Know, the testing result that Essence water color, turbidity, cold-resistant heat resistant test and pH value are repaired in polypeptide whitening meets middle Chinese
The sense organ of people republic light industry standard 0B/T 2660-2004, physical and chemical index regulation show to add three kinds to polypeptide beauty
The white quality index for repairing Essence is substantially without influence.
Essence Detection of Stability result is repaired in 3 polypeptide whitening of table
| Project | As a result |
| Appearance | Uniform liquid is free from foreign meter |
| Heat-resistant experiment | (40 ± 1) DEG C are kept for 24 hours, preceding without obvious Traits change with test after restoring to room temperature |
| Cold-resistant experiment | (5 ± 1) DEG C are kept for 24 hours, preceding without obvious Traits change with test after restoring to room temperature |
| pH | About 7.0 |
Experimental example 3
By example 1, into example 5, essence liquid product is repaired in polypeptide whitening obtained, is repaired Essence with existing whitening and is produced
Product carry out Experimental comparison, experiment condition are as follows: 50 women of volunteer the age 20-45 years old, use 2 times, continuous use 28 daily
It.Shown in experimental result such as following table (table 4):
Essence is repaired in 4 polypeptide whitening of table and the comparison of Essence is repaired in existing whitening
Experimental result shows that polypeptide whitening of the present invention is repaired the whitening of Essence, repairing effect etc. and is substantially better than now
There is product.
Bibliography
[1] Zhong Xing, Guo Jianwei, Cheng Qiugui win application and latest developments [J] household chemicals section of the peptide in cosmetics
It learns, 2012,35 (11): 35-38
[2]Papini A M.Cosmetics towards peptide-based cosmeceutics[J]
.ChimicaOggi/Che- mistry Today,2010,28(6):3-4
[3] application the 10th south east asia medical cosmetology of [c] of yellow Yadong biologically active polypeptide in medical cosmetology
Academic conference collection of thesis, 2006:14-17
[4] Li Jiaokun, Yao Chengcan, the basis of the biologically active polypeptide skin care item such as yellow Yadong and application [J] days useization
Learn industry, 2002,32 (5): 4 1-43.
[5] Li Chunrong, perhaps faithful and upright, study on the synthesis [J] the South China Normal University of Wang Hui natural N-BETA-Alanyl-L-histidine is learned
Report: natural science edition, 2007,1 (2): 89-92.
Claims (10)
1. Essence is repaired in a kind of polypeptide whitening, which is characterized in that weight percentage, including following components:
2. Essence is repaired in polypeptide whitening according to claim 1, which is characterized in that weight percentage, including
Following components:
3. Essence is repaired in polypeptide whitening according to claim 1, which is characterized in that weight percentage, including
Following components:
4. Essence is repaired in polypeptide whitening according to claim 1, which is characterized in that weight percentage, including
Following components:
5. Essence is repaired in polypeptide whitening according to claim 1, which is characterized in that weight percentage, including
Following components:
6. Essence is repaired in any polypeptide whitening according to claim 1 to 3, which is characterized in that the hexapeptide -10, ten
Tripeptides -1, three kinds of beauty polypeptides of carnosine total weight percent 15~20%.
7. Essence is repaired in any polypeptide whitening described in -5 according to claim 1, which is characterized in that the hexapeptide -10, ten
Tripeptides -1, three kinds of beauty polypeptides of carnosine purity in 95-99%.
8. a kind of method for preparing polypeptide whitening described in claim 1~7 any one claim and repairing Essence, special
Sign is that this method includes the following steps:
1) water, glycerol, propylene glycol, vitamin C, vitamin E, ferulic acid, panthenol and hyaluronic acid, allantoin and laruyl alcohol are gathered
Ether -23 is added in reactor tank, opens stirring, is heated to 75~80 DEG C, is dispersed with stirring uniformly；
2) cooling circulating water is opened, when temperature is down to 45~50 DEG C reaction is added in Phenoxyethanol, triethanolamine by stirring cooling
In tank, homogeneous 1 minute, stirring and dissolving was complete；
3) continue stirring to be cooled to lower than 37 DEG C, hexapeptide -10, tridecanoic peptide -1, carnosine are added in reactor tank, homogeneous 2-3 minutes,
Stirring and dissolving is complete.
9. Essence is repaired in polypeptide whitening described in claim 1 repairs cell in damaged condition in preparation, promote neonatal cell proliferation, suppression
The formation of melanin processed, the application in the product of skin whitening.
It prevents wrinkle of skin from generating in preparation 10. Essence is repaired in polypeptide whitening described in claim 1, slows down skin aging, subtract
The application in product that few skin lines generate.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610152922.3A CN106265134B (en) | 2016-03-17 | 2016-03-17 | Essence and preparation method thereof is repaired in a kind of polypeptide whitening |
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|---|---|---|---|
| CN201610152922.3A CN106265134B (en) | 2016-03-17 | 2016-03-17 | Essence and preparation method thereof is repaired in a kind of polypeptide whitening |
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| CN106265134B true CN106265134B (en) | 2019-02-19 |
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| CN107375005B (en) * | 2017-08-07 | 2021-03-23 | 深圳市维琪医药研发有限公司 | Polypeptide composition with antioxidation and melanin synthesis inhibition functions and application thereof |
| CN108158842B (en) * | 2018-01-24 | 2020-12-18 | 郑州瀛元生物科技有限公司 | Ground beetle polypeptide essence and preparation method thereof |
| CN108635275B (en) * | 2018-07-27 | 2020-08-14 | 北京化工大学 | Antioxidant composition and application thereof in essence |
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| CN113876637A (en) * | 2021-11-15 | 2022-01-04 | 江西灏洋生物科技有限公司 | Anti-sugar repair mask with moisturizing and hydrating effects and preparation method thereof |
| CN114869796B (en) * | 2022-05-06 | 2023-06-13 | 浙江湃肽生物股份有限公司 | Whitening and skin-brightening repair composition containing active polypeptide and application thereof |
| CN115089508A (en) * | 2022-07-08 | 2022-09-23 | 西安惠普生物科技有限公司 | Skin whitening essence containing holothurin and preparation method thereof |
| CN115227600B (en) * | 2022-08-01 | 2023-12-05 | 上海澄穆生物技术有限公司 | Composition with antioxidant whitening function and preparation method and application thereof |
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| ATE84420T1 (en) * | 1986-02-03 | 1993-01-15 | University Patents Inc | METHODS OF STIMULATION OF MELANOCYTES BY LOCAL APPLICATION OF ALPHA-MSH ANALOGUES, AND COMPOSITIONS. |
| CN105030574A (en) * | 2015-06-19 | 2015-11-11 | 周南燕 | Facial care composition |
| CN109966471A (en) * | 2015-08-28 | 2019-07-05 | 宇肽生物(东莞)有限公司 | A kind of peptide composition for skin repair |
| CN105362088B (en) * | 2015-12-22 | 2019-05-17 | 深圳市维琪医药研发有限公司 | A kind of peptide composition for the light spot of whitening skin lightening |
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