CN106726668A - A kind of many peptidoliposome raw materials used in cosmetics - Google Patents
A kind of many peptidoliposome raw materials used in cosmetics Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
A kind of many peptidoliposome raw materials used in cosmetics, comprising by carnosine, palmityl tripeptides 1, palmityl tetrapeptide 7, Matrixyl 4, acetyl group hexapeptide 8, lecithin (and) propane diols and the alcohol malates of two C12 13.For sensitiveness skin, compacted skin and reparation wrinkle functional cosmetics, reaches and releives and improve skin sensitivity, promotes collagen and hyaluronic acid synthesis, and maintenance skin is damaged, with effect of the skin with reparation deep wrinkles of compacting.
Description
Technical field
The present invention relates to cosmetic technical field, specifically one kind is with carnosine, palmityl tripeptides -1, palmityl four
Peptide -7, Matrixyl -4, Argireline are main raw material, with C12-13 alcohol malate solubilising, use lecithin
(and) the lipid encapsulation body that is wrapped up of propane diols, it is mainly used in improving sensitiveness skin problem, compact and skin and repair wrinkle
Functional cosmetics.
Background technology
Skin be covered in one of whole body surface it is important and be a maximum organ, it is human internal organs
With the Protector of tissue, meanwhile, be also internal, spirit and the effector organ of surrounding environment, to the healthy and beauty of human body
Play particularly important effect.
With the economy of high density population and social activities, a large amount of fine particles (PM2.5) will necessarily be discharged, once discharge
More than atmospheric air circulation ability and carrying degree, continued accumulation is caused municipal pollution by fine particle concentration.It is commonly exposed to air friendship
The women of logical pollution particle environment higher, pollutant combines fragrant acceptor (causing fragrant receptor activation), cause skin aging and
The expression of pigmentation related gene, and produce oxidative stress to cause scytitis.Recent research is also pointed out the interior of China
Relation between air pollution and skin premature aging, correspondingly, is being based respectively on Beijing (n=400) and Taizhou (n=1000)
Two independent queues in, discovery with fossil fuel cook and skin coarse groove generate between it is significantly correlated.Produced in skin big
The pollution molecule of amount, and serious infringement skin surface, the natural regeneration ability of serious obstruction skin, cause sensitiveness skin patient
It is more and more.
Whether one skin care of people is proper and living environment has much relations, in skin nursing and beauty scientific progress
Epoch, the skin of human body is protected and repaired using effective feature skin protection cosmetics, be sensitiveness skin, skin damage and
The fine wrinkles for Time fleets past producing, it is reasonably particularly important from a suitable cosmetics.Therefore, exploitation has reparation flesh
Skin is damaged, and compact skin and reparation wrinkle, moreover it is possible to which the cosmetics for being adapted to sensitiveness crowd are very important.
The content of the invention
The purpose of the present invention is：A kind of composition of many peptidoliposome raw materials used in cosmetics is provided, for quick
Perceptual skin, compacts and skin and repairs wrinkle functional cosmetics, reaches that to releive and improves skin sensitive, promote collagen with
Hyaluronic acid synthesizes, and maintenance skin is damaged, the effect with compact skin and reparation deep wrinkles.
What the present invention was realized in：A kind of many peptidoliposome raw materials used in cosmetics, comprising by carnosine, palm
Acyl tripeptides -1, palmityl tetrapeptide -7, Matrixyl -4, Argireline, C12-13 alcohol malate, lecithin (and) third
Glycol.
A kind of described many peptidoliposome raw materials used in cosmetics, it is characterized in that：Its weight
For：
Carnosine content range is 0.002-0.01g,
The content range of palmityl tripeptides -1 is 0.0002-0.01g,
The content range of palmityl tetrapeptide -7 is 0.0001-0.01g,
The content range of Matrixyl -4 is 0.006-0.01g,
Argireline content range is 0.05-0.1g,
Two C12-13 alcohol malate content ranges 1000-10000g
Lecithin (and) content of propylene glycol scope 30000-95000g.
A kind of described many peptidoliposome raw materials used in cosmetics, it is characterized in that：
Its preparation method is according to the following steps：
(1) preparation of phosphatide inclusion enclave (oil)：
A phases：
C12-13 alcohol malates,
Palmityl tripeptides -1,
Palmityl tetrapeptide -7, Matrixyl -4,
B phases：
Lecithin (and) propane diols,
Production technology：At ambient temperature, A is mixed it is transparent, under high velocity agitation add B phases in, be sufficiently stirred for
It is even；
(2) finished product
A phases：Water,
Carnosine,
Argireline,
B phases：Phosphatide inclusion enclave (oil),
At ambient temperature, A is mixed it is transparent, under high velocity agitation add B phases in, stir.
A kind of described many peptidoliposome raw materials used in cosmetics, it is characterized in that：Many peptidoliposomes are former
Material is made up of liposome technology, with splendid intermiscibility and stability, for lotion, moisturizing lotion, skin cream, essence
In magnificent liquid and mask product, can be suspended or dispersed in formula system, the polypeptide active thing of liposome is extremely easy to by skin
Absorb, can releive and improve skin, promote collagen and hyaluronic acid synthesis, maintenance skin is damaged, compact skin with repair
Multiple deep wrinkles.
Carnosine is a kind of multi-functional anti-aging cosmetics raw material, with powerful oxidation resistance, can comprehensively prevent each
Damage of the environmental oxidation factor to cell is planted, significantly delays the aging and degeneration of cell.Experiment in vitro shows that carnosine can recover thin
The activity of born of the same parents' hepatocuprein (SOD), recovers the ability of its scavenging activated oxygen, reaches the effect of protection skin cell；
The content of cell MDA (MDA) is reduced, destruction of the oxidative damage to cell membrane can be reduced, there is obvious protection to cell membrane
Effect；Recover catalase (CAT) activity, the ability of its catalytic decomposition hydrogen peroxide can be strengthened, it is to avoid cell is oxidized broken
It is bad；Effectively suppress the overexpression of (MMP-1) albumen of cellular metal stromatin enzyme -1, reduce its degraded to collagen and make
With, the normal configuration of skin corium is thus kept, slow down the aging of skin.
Palmityl tripeptides -1 come from the fragment on I-type collagen chain, to skin cell renewal, repair, collagen egg
White synthesis has obvious regulation and control and facilitation.This fragment modified by palmityl after its fat-soluble reinforcement, can preferably by skin
Skin absorbs, and reaches the effect of firm skin.Testing in vitro shows that palmityl tripeptides -1 are used in combination with other polypeptides can be significantly
Promote the synthesis of collagen and hyaluronic acid in fibroblast so that skin largely synthesizes collagen, increase skin
Moisturizing power, maintenance deep wrinkles, skin compacts and young；Being used in combination with anti-inflammatory polypeptide can significantly recover to damage thin by ultraviolet
The vigor of born of the same parents, has good action in the ultraviolet maintenance skin health state aspect that damages of Antagonistic Environment.Clinical trial shows, palmityl
The mixed polypeptide of tripeptides -1 is to anti-wrinkle effect is significant.It is used in combination with palmityl tetrapeptide -7, can effectively facilitate fibroblast
The synthesis of middle collagen and hyaluronic acid, crease-resistant, anti-inflammatory, the effect is significant of antiallergic.
Palmityl tetrapeptide -7 is derived from a fragment in immunoglobulin lgG, and this fragment is more held after being modified by palmityl
Easily be absorbed by the skin, and the level of inflammatory factor interleukin (IL-6) can be significantly reduced, it have eliminate skin potential inflammation,
The effect of antiallergic, produces to mitigating wrinkle, and recovering skin vigor has remarkable efficacy.Testing in vitro shows, palmityl tetrapeptide -7
The injury that can reduce inflammation the inhibitory action of relevant inflammatory factors to skin, the intensification especially reduced inflammation to wrinkle
Effect；Also there is restitution to ultraviolet damaging cells.Clinical trial shows that palmityl tetrapeptide -7 is used in combination with other polypeptides
When to anti-wrinkle effect is significant.It is used in combination with palmityl tripeptides -1, can effectively facilitate in fibroblast collagen and
The synthesis of hyaluronic acid, crease-resistant, anti-inflammatory, the effect is significant of antiallergic.
Matrixyl -4 is I-type collagen precursor sequence fragment, it can in intense stimulus extracellular matrix (ECM) into
The growth of fibrocyte, so as to stimulate the synthesis of I and type III collagen and fibrin and hyaluronic acid.As signal
Peptide, collagen generation in its significant stimulation dermal layer of the skin, particular for deep wrinkles effect is significant.Testing in vitro shows,
The recovery of the ultraviolet damaging cells of Matrixyl -4 pairs, the rush synthesized to I-type collagen, fibronectin bletilla hyaluronic acid
Enter effect, delay the process of skin ageing.Clinical trial shows that Matrixyl -4 is in wrinkle depth, wrinkle roughness, wrinkle
Streakline closeness aspect is all significantly improved effect.
Argireline is one of earliest and most widely used crease-resistant polypeptide.Similar to creotoxin, it can smooth or
Reduce and the expression line for causing is shunk by facial muscles expression, especially near the eyes, the position that the expression muscle such as forehead and the corners of the mouth is concentrated.
Research shows that Argireline participates in competition Protein S NAP-25 and melting the site of bubble complex, is allowed to effectively discharge god
Through mediator, contraction of muscle is reduced, reduce and improve wrinkle.Clinical trial shows that Argireline is in wrinkle roughness, wrinkle
Closeness aspect is significantly improved effect.
More than in addition to 5 kinds of compositions, also comprising the customary adjuvant needed for preparing cosmetics, including as emollient, emulsifying agent
With oiliness (phase) component of antioxidant, such as White Mineral Oil, shea butter, jojoba seed oil, octanoic acid/certain herbaceous plants with big flowers acid glycerol three ester, poly- two
Methylsiloxane, cetostearyl alcohol, isononyl isononanoate, tetradecylic acid, stearic acid etc., cocoyl glucoside, the smooth stearic acid of sorb
Ester, Glyceryl stearate citrate, Butylated Hydroxytoluene etc.；Water phase components, mainly there is water, glycerine, propane diols, butanediol, Chinese life
Glue, Carbomer, potassium hydroxide etc.；Surfactant has anion, such as benign and nonionic surface active agent, laureth
Sodium sulfovinate, sodium lauroyl sarcosine, Cocoamidopropyl betaine, sodium methyl cocoyl taurate etc.；Superfatting agent, such as
The acid of PEG-7 sodium cocoglyceryls, isostearic acid sodium lactate, silicone emulsion etc.；Preservative, such as methyl hydroxybenzoate, Nipasol, double (hydroxyls
Methyl) imidazolidinyl urea, methylisothiazolinone, Phenoxyethanol, Chlorphenesin etc.；Other effective active things, such as niacinamide, dimension
Raw element E, allantoin, bisabolol, yeast extract etc.；Sun-screening agent raw material, such as ethylhexyl methoxy cinnamate, Hu Moliu
Ester, Octocrilene, Phenylbenzimidazolesulfonic acid etc..
Specific embodiment
With reference to embodiment, the invention will be further described.
A kind of many peptidoliposome raw materials used in cosmetics, comprising by carnosine, palmityl tripeptides -1, palmityl four
Peptide -7, Matrixyl -4, Argireline, lecithin (and) propane diols, two C12-13 alcohol malates.By weight
Calculate
(1) phosphatide inclusion enclave (oil)
B phases：Lecithin (and) propane diols 95000g；
Production technology：
At ambient temperature, A is mixed it is transparent, under high velocity agitation add B phases in, stir.
(2) many peptidoliposome raw materials
Material name：Weight
A phases：Water 70000g,
Carnosine 0.01g,
Argireline 0.1g,
B phases：(1) phosphatide inclusion enclave (oil) 30000g,
At ambient temperature, A is mixed it is transparent, under high velocity agitation add B phases in, stir.
Example one：
The soft and moist water of moisturizing
The percentage by weight of formula：
(B) propane diols 5%, Phenoxyethanol 0.3%,
Sensiva SC50 0.2%,
(C) Cremophor RH40 0.1%, essence 0.03%,
(D) many peptidoliposome raw materials 1%,
Production technology：
1st, A (water phase) is stirred and heated to 90 DEG C, is incubated 10 minutes, be well mixed, open cooling.
2nd, 40 DEG C are being cooled to, the B and component C of homogeneous transparent will be pre-mixed, be slowly added to be sufficiently stirred in A (water phase)
Uniformly；
3rd, D component raw materials are sequentially added to stir, is discharged.
Example two：
Moisturiser
Formulation weight percentage：
A (water phase) deionized water to 100,
EDETATE SODIUM 0.05%, glycerine 5%,
Carbomer 0.35%, hyaluronic acid 0.03%,
(B)
(C)
Phenoxyethanol 0.5%, Sensiva SC50 0.2%,
Potassium hydroxide 0.1%, essence 0.03%,
Many peptidoliposome raw materials 2%,
Production technology：
1st, A (water phase) is stirred and heated to 85 DEG C, is incubated 10 minutes, be well mixed；
2nd, B (oil phase) is stirred and heated to 85 DEG C, is incubated 10 minutes, be well mixed；
3rd, A (water phase) is pumped into emulsion tank, then well mixed B (oil phase) is slowly added to carry out closing phase homogenized milk
Change；After insulation 10 minutes, stirring cooling；
4th, 40 DEG C are cooled in emulsion tank, component C raw material is added according to this, stir discharging.
Example three：
Humidity-preserving type mildy wash
The percentage by weight of formula：
A (water phase) deionized water to 100,
EDETATE SODIUM 0.05%, laureth sodium sulfovinate 5%,
Carbomer 0.35%, hyaluronic acid 0.03%,
(B)
(C)
Phenoxyethanol 0.5%, Sensiva SC50 0.2%,
Potassium hydroxide 0.1%, essence 0.03%,
Many peptidoliposome raw materials 0.1%
Production technology：
1st, A (water phase) is stirred and heated to 85 DEG C, is incubated 10 minutes, be well mixed；
2nd, B (oil phase) is stirred and heated to 85 DEG C, is incubated 10 minutes, be well mixed；
3rd, A (water phase) is pumped into emulsion tank, then well mixed B (oil phase) is slowly added to carry out closing phase homogenized milk
Change；After insulation 10 minutes, stirring cooling；
4th, 40 DEG C are cooled in emulsion tank, component C raw material is added according to this, stir discharging.
Example four：
Moisturizing eye cream
The percentage by weight of formula：
Production technology：
1st, A (water phase) is stirred and heated to 85 DEG C, is incubated 10 minutes, be well mixed；
2nd, B (oil phase) is stirred and heated to 85 DEG C, is incubated 10 minutes, be well mixed；
3rd, A (water phase) is pumped into emulsion tank, then well mixed B (oil phase) is slowly added to carry out closing phase homogenized milk
Change；After insulation 10 minutes, stirring cooling；
4th, 40 DEG C are cooled in emulsion tank, component C raw material is added according to this, stir discharging.
A kind of technical combinations of many peptidoliposome raw materials contained in cosmetics of present invention offer are applied to cosmetics three
Large effect：(1) powerful oxidation resistance, can comprehensively prevent damage of the various environmental oxidation factors to cell, effectively suppress thin
The overexpression of born of the same parents' metallo-matrix proteases -1 (MMP-1) albumen, reduces its degradation to collagen, thus keeps true
The normal configuration of cortex, significantly delays the aging and degeneration of cell；(2) collagen and thoroughly can be effectively facilitated in fibroblast
The synthesis of bright matter acid, repairs skin and damages, and crease-resistant, anti-inflammatory, the effect is significant of antiallergic, sensitiveness skin are applicable；(3) can smooth or
Reduce and the expression line for causing is shunk by facial muscles expression, especially near the eyes, the position that the expression muscle such as forehead and the corners of the mouth is concentrated.
Research shows, effect is significantly improved in terms of wrinkle roughness, wrinkle closeness.
Above-described is only preferred embodiments of the invention.It should be pointed out that for the ordinary skill of this area
For personnel, without departing from the principles of the present invention, some improvement and modification can also be made, this is also considered as of the invention
Protection domain.
Claims (4)
1. a kind of many peptidoliposome raw materials used in cosmetics, comprising by carnosine, palmityl tripeptides -1, palmityl tetrapeptide -
7th, Matrixyl -4, Argireline, lecithin (and) propane diols and two C12-13 alcohol malates.
2. a kind of many peptidoliposome raw materials used in cosmetics according to claim 1, it is characterised in that：Its weight
Part matches：
Carnosine content range is 0.002-0.01g,
The content range of palmityl tripeptides -1 is 0.0002-0.01g,
The content range of palmityl tetrapeptide -7 is 0.0001-0.01g,
The content range of Matrixyl -4 is 0.006-0.01g,
Argireline content range is 0.05-0.1g,
Two C12-13 alcohol malate content ranges 1000-10000g
Lecithin (and) content of propylene glycol scope 30000-95000g.
3. a kind of many peptidoliposome raw materials used in cosmetics according to claim 2, it is characterised in that：
Its preparation method is according to the following steps：
(1) preparation of phosphatide inclusion enclave (oil)：
A phases：
C12-13 alcohol malates, palmityl tripeptides -1,
Palmityl tetrapeptide -7, Matrixyl -4,
B phases：
Lecithin (and) propane diols,
Production technology：At ambient temperature, A is mixed it is transparent, under high velocity agitation add B phases in, stir；
(2) finished product
A phases：Water, carnosine, Argireline,
B phases：Phosphatide inclusion enclave (oil),
At ambient temperature, A is mixed it is transparent, under high velocity agitation add B phases in, stir.
4. a kind of many peptidoliposome raw materials used in cosmetics according to claim 1 and 2, it is characterised in that：It is many
Peptidoliposome raw material is made up of liposome technology, with splendid intermiscibility and stability, for lotion, milky lotion
Liquid, skin cream in Essence and mask product, can be suspended or dispersed in formula system, the polypeptide active thing of liposome
It is extremely easy to be absorbed by the skin, can releives and improve skin, promote collagen and hyaluronic acid synthesis, maintenance skin is damaged,
Compact skin and reparation deep wrinkles.
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| CN115025007A (en) * | 2022-06-30 | 2022-09-09 | 广州长生康生物科技有限公司 | Polypeptide anti-wrinkle essence and preparation method thereof |
| CN115813806A (en) * | 2022-12-07 | 2023-03-21 | 广州真如化妆品有限公司 | Lip and cheek dual-purpose liquid with effects of enlarging lips and firming apple muscles and preparation method thereof |
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