CN115025007A - Polypeptide anti-wrinkle essence and preparation method thereof - Google Patents
Polypeptide anti-wrinkle essence and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/895—Polysiloxanes containing silicon bound to unsaturated aliphatic groups, e.g. vinyl dimethicone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention discloses polypeptide anti-wrinkle essence and a preparation method thereof. Polypeptide anti-wrinkle essence, which comprises: cyclopenta-dimethylsiloxane, dimethicone/vinyl dimethicone crosspolymer, dimethicone, hydrogenated polyisobutylene, polyglyceryl-4laurate, PEG-6caprylic/capric glycerides, water, tripeptide-1, acetyl hexapeptide-8, pentapeptide-3, tocopherol, C30-45 alkyl methicone, C30-45 olefins, silica, ascorbyl tetraisopalmitate, squalane, and fragrance. The invention also provides a preparation method of the polypeptide anti-wrinkle essence.
Description
Technical Field
The invention relates to the field of skin care products, and in particular relates to polypeptide anti-wrinkle essence and a preparation method thereof.
Background
The essence in the prior art has a common effect on resisting wrinkles and is high in component cost. Because the anti-wrinkle functional components are mostly water-soluble substances, and the capsule skin care product mainly contains grease, the addition amount of the anti-wrinkle functional substances in the existing capsule product is small, and a good anti-wrinkle effect is difficult to achieve.
The peptide is a raw material which is generally accepted to have the anti-wrinkle effect, is formed by condensing amino of one amino acid and carboxyl of another amino acid, is insoluble in oil, and is difficult to be added into an oily capsule skin care product.
Disclosure of Invention
Based on the above, the invention aims to provide a polypeptide anti-wrinkle essence and a preparation method thereof.
In a first aspect, a polypeptide anti-wrinkle essence comprises: cyclopentadimethylsiloxane, dimethicone/vinyl dimethicone crosspolymer, dimethicone, hydrogenated polyisobutylene, polyglycerol-4 laurate, PEG-6caprylic/capric glycerides, water, tripeptide-1, acetyl hexapeptide-8, pentapeptide-3, tocopherol, C30-45 alkyl methicone, C30-45olefin, silica, ascorbyl tetraisopalmitate, squalane, and fragrance.
In one embodiment, the above technical solution comprises, by mass: cyclopentasiloxane 79.02%, dimethicone/vinyl dimethicone crosspolymer 10.73%, dimethicone 1.5%, hydrogenated polyisobutene 2.5425%, polyglycerol-4 laurate 0.24%, PEG-6caprylic/capric glycerides 0.15%, water 0.06%, tripeptide-10.0006%, acetyl hexapeptide-80.0063%, pentapeptide-30.0006%, tocopherol 2%, C30-45 alkyl methicone 0.75%, C30-45 alkene 0.75%, silica 1.05%, ascorbyl tetraisopalmitate 0.5%, squalane 0.5%, and fragrance 0.2%.
In a second aspect, a method for preparing a polypeptide anti-wrinkle essence is provided, which is used for preparing the polypeptide anti-wrinkle essence and comprises the following steps:
adding part of cyclopentadimethyl siloxane into an emulsifying pot, stirring, heating, adding a mixture of cyclopentadimethyl siloxane and polydimethylsiloxane, C30-45 alkyl polymethyl siloxane and C30-45olefin, and stirring until the cyclopentadimethyl siloxane and the polydimethylsiloxane are dissolved;
adding the rest cyclopentadimethylsiloxane and the polydimethylsiloxane/vinyl polydimethylsiloxane cross-linked polymer into an emulsifying pot, and uniformly stirring and homogenizing;
cooling, adding hydrogenated polyisobutene, polyglycerol-4 laurate, PEG-6caprylic/capric glycerides, water, tripeptide-1, acetyl hexapeptide-8, pentapeptide-3, tocopherol, ascorbyl tetraisopalmitate, squalane and essence, and stirring and homogenizing uniformly;
adding silica, stirring and homogenizing uniformly;
filtering and discharging to obtain the polypeptide anti-wrinkle essence.
In one embodiment of the technical scheme, part of cyclopentadienyldimethylsiloxane is put into an emulsifying pot, stirred at the stirring speed of 10-20 revolutions per minute and heated to 70 ℃.
In one embodiment, the mixture of cyclopentadimethylsiloxane and polydimethylsiloxane, C30-45 alkyl polymethylsiloxane and C30-45olefin are added and stirred until the mixture is dissolved, wherein the stirring speed is 1800-2300 rpm, and the stirring time is 5 min.
In one embodiment of the technical scheme, the rest cyclopentadimethylsiloxane and the polydimethylsiloxane/vinyl polydimethylsiloxane cross-linked polymer are added into an emulsifying pot and stirred uniformly, wherein the stirring speed is 10-20 rpm, and the homogenizing speed is 1800 plus one 2300 rpm.
In one embodiment of the technical scheme, the temperature is reduced to 45 ℃ or below, hydrogenated polyisobutene, polyglycerol-4 laurate, PEG-6caprylic/capric glycerides, water, tripeptide-1, acetyl hexapeptide-8, pentapeptide-3, tocopherol, ascorbyl tetraisopalmitate, squalane and essence are added, and the mixture is stirred and homogenized uniformly, wherein the stirring speed is 10-20 revolutions per minute.
In one embodiment, silica is added and stirred uniformly, wherein the stirring speed is 10-20 rpm, and the homogenizing speed is 1800-.
In one embodiment of the above technical solution, the preparation method further comprises: and sampling and detecting the prepared polypeptide anti-wrinkle essence, and transferring the material body to a standing room.
In one embodiment, the preparation method further comprises: the polypeptide anti-wrinkle essence can be filled into capsules, and the pelleting temperature is controlled at 38-48 ℃.
In one embodiment of the above technical solution, the preparation method further comprises: drying the mixture by capsules at the drying temperature of 21-25 ℃ and the relative humidity of less than or equal to 45 percent;
selecting the capsules, and packaging to obtain the finished product.
Compared with the prior art, the polypeptide anti-wrinkle essence disclosed by the invention is based on cyclopentadimethylsiloxane and polydimethylsiloxane/vinyl polydimethylsiloxane cross-linked polymerization, is smooth in skin feel, free of greasy feel, fast to absorb and capable of bringing better experience feel; acetyl hexapeptide-8, tripeptide-1 and pentapeptide-3 are adopted, so that the tea is rich in various high-activity polypeptides, multiple targets block nerve signal conduction formed by wrinkles, dynamic fine lines can be quickly faded, a V face can be tightly shaped, and the problems of texture processes such as eye lines, raised lines, statutory lines and the like can be safely solved; the adopted tocopherol (vitamin E) and ascorbyl tetraisopalmitate have certain effect of removing free radicals, and reduce the oxidation of the free radicals to the collagen structure, thereby achieving the effect of resisting wrinkles. The polypeptide anti-wrinkle essence disclosed by the invention has the characteristics of quick anti-wrinkle effect, easiness in absorption and no greasiness.
For a better understanding and practice, the invention is described in detail below with reference to the accompanying drawings.
Drawings
Fig. 1 is a block diagram illustrating an exemplary process for preparing the polypeptide anti-wrinkle essence of the present invention.
Detailed Description
The terms of orientation of up, down, left, right, front, back, top, bottom, and the like, referred to or may be referred to in this specification, are defined relative to their configuration, and are relative concepts. Therefore, it may be changed according to different positions and different use states. Therefore, these and other directional terms should not be construed as limiting terms.
The implementations described in the exemplary embodiments below are not intended to represent all implementations consistent with the present disclosure. Rather, they are merely examples of implementations consistent with certain aspects of the present disclosure.
The terminology used in the present disclosure is for the purpose of describing particular embodiments only and is not intended to be limiting of the disclosure. As used in this disclosure, the singular forms "a", "an", and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It should also be understood that the term "and/or" as used herein refers to and encompasses any and all possible combinations of one or more of the associated listed items.
In a first aspect, a polypeptide anti-wrinkle essence comprises: cyclopentadimethylsiloxane (CYCLOPENTASILOXANE), DIMETHICONE/VINYL DIMETHICONE CROSSPOLYMER (DIMETHICONE/vinyldimethicone cross-linked polymer), DIMETHICONE (DIMETHICONE), HYDROGENATED POLYISOBUTENE (HYDROGENATED POLYISOBUTENE), polyglycerol-4 LAURATE (POLYGLYCERYL-4LAURATE), PEG-6CAPRYLIC/capric glycerides (PEG-6 caprilic/CAPRIC GLYCERIDES), water (AQUA), tripeptide-1 (TRIPEPTIDE-1), ACETYL HEXAPEPTIDE-8 (ACETYL HEXAPEPTIDE-8), PENTAPEPTIDE-3 (PENTAPEPTIDE-3), TOCOPHEROL (tocophenol), C30-45 ALKYL polymethylsiloxane (C30-45 ALKYL METHICONE), C30-45OLEFIN (C30-45OLEFIN), SILICA (SILICA), ASCORBYL TETRAISOPALMITATE (ASCORBYL TETRAISOPALMITATE), SQUALANE (SQUALANE), and essence (AROMA).
Wherein cyclopentadimethylsiloxane (CYCLOPENTASILOXANE), DIMETHICONE/VINYL DIMETHICONE CROSSPOLYMER (DIMETHICONE/VINYL DIMETHICONE cross polymer), DIMETHICONE (DIMETHICONE), C30-45 ALKYL METHICONE (C30-45 ALKYL METHICONE), C30-45 alkene (C30-45OLEFIN) and SQUALANE (SQUALANE) are used as emollients.
HYDROGENATED POLYISOBUTENE (HYDROGENATED POLYISOBUTENE), polyglycerol-4 LAURATE (polyglycerol-4 LAURATE), PEG-6CAPRYLIC/capric glycerides (PEG-6 caprilic/CAPRIC GLYCERIDES), water (AQUA), tripeptide-1 (TRIPEPTIDE-1), ACETYL HEXAPEPTIDE-8 (ACETYL HEXAPEPTIDE-8), PENTAPEPTIDE-3 (PENTAPEPTIDE-3), and ASCORBYL TETRAISOPALMITATE (ASCORBYL TETRAISOPALMITATE) as skin conditioners.
TOCOPHEROL (tocophenol) is used as antioxidant.
SILICA (SILICA) as a thickener.
Perfume (AROMA) as fragrance.
The invention is based on cyclopentadecyldimethylsiloxane and polydimethylsiloxane/vinyl polydimethylsiloxane cross-linked polymerization, has smooth skin feel, no greasy feel and quick absorption, and can bring better experience.
Acetyl hexapeptide-8 is an N-terminal mimetic of the neurotensin SNAP25 and therefore competes for binding at SNAP25 to form a SNAP protein complex, the normally SNAP25 bound SNAP triggers the release of acetylcholine between nerve synapses, allowing neurotransmission to proceed, and acetyl hexapeptide-8 binding results in instability of the SNAP complex, affecting neurotransmitter release, also blocking muscle contraction, preventing the formation of wrinkles and fine lines. Meanwhile, the acetyl hexapeptide-8 has the characteristic of higher safety because subcutaneous muscle refraction is not required.
The tripeptide-1 has extremely strong permeability, acts on the epidermis layer and the dermis layer of the skin, promotes the generation of fibroblasts, and stimulates the combination of glycoprotein of an extracellular matrix structure; removing lipid peroxidation by-products, and removing and preventing cellulite; the anti-free radical can make the skin more moist; promoting the synthesis of hyaluronic acid; enhancing levels of core proteoglycans and basement membrane glycans; promoting wound recovery and tissue regeneration, strengthening dermis to make skin thicker and firmer, relieving wrinkles, resisting ultraviolet irradiation, and reducing skin injury.
The invention adopts acetyl hexapeptide-8, tripeptide-1 and pentapeptide-3, is rich in various high-activity polypeptides, blocks nerve signal conduction formed by wrinkles at multiple target points, can quickly fade dynamic fine lines, tightly moulds a V face, and safely solves the problems of texture processes such as eye lines, raising lines, statutory lines and the like.
The invention adopts tocopherol (vitamin E) and ascorbyl tetraisopalmitate, has certain effect of eliminating free radicals, reduces the oxidation of the free radicals to the collagen structure, and achieves the anti-wrinkle effect.
Examples
The polypeptide anti-wrinkle essence comprises the following components in percentage by mass: cyclopentasiloxane 79.02%, dimethicone/vinyl dimethicone crosspolymer 10.73%, dimethicone 1.5%, hydrogenated polyisobutene 2.5425%, polyglycerol-4 laurate 0.24%, PEG-6caprylic/capric glycerides 0.15%, water 0.06%, tripeptide-10.0006%, acetyl hexapeptide-80.0063%, pentapeptide-30.0006%, tocopherol 2%, C30-45 alkyl methicone 0.75%, C30-45 alkene 0.75%, silica 1.05%, ascorbyl tetraisopalmitate 0.5%, squalane 0.5%, and fragrance 0.2%.
The embodiment of the invention is based on 79.02% of cyclopentadimethylsiloxane and 10.73% of polydimethylsiloxane/vinyl polydimethylsiloxane crosslinked polymer, has smooth skin feel, no greasy feel and quick absorption, and can bring better experience.
The embodiment of the invention adopts 0.0063% of acetyl hexapeptide-8, 0.0006% of tripeptide-1 and 0.0006% of pentapeptide-3, is rich in various high-activity polypeptides, can block nerve signal conduction formed by wrinkles by multiple targets, can quickly fade dynamic fine lines, tightly mould V faces, and safely solve the problems of texture processes such as eye lines, head raising lines, stature lines and the like. In the amount added, a slight decrease in the texture was observed after 15 minutes.
In the embodiment of the invention, 2% of tocopherol (vitamin E) and 0.5% of ascorbyl tetraisopalmitate are adopted, so that the effect of removing free radicals is achieved to a certain extent, the oxidation of the free radicals to a collagen structure is reduced, and the anti-wrinkle effect is achieved. Through DPPH free radical clearance test, the invention can reach more than 70% free radical clearance.
In a second aspect, a method for preparing a polypeptide anti-wrinkle essence for preparing the polypeptide anti-wrinkle essence of the above embodiments includes:
101, putting part of cyclopentadimethyl siloxane into an emulsifying pot, stirring, heating, adding a mixture of cyclopentadimethyl siloxane and polydimethylsiloxane, C30-45 alkyl polymethyl siloxane and C30-45olefin, and stirring until the cyclopentadimethyl siloxane and the polydimethylsiloxane are dissolved.
Preferably, part of cyclopentadimethylsiloxane is put into an emulsifying pot, stirred at the speed of 10-20 r/min and heated to 70 ℃.
The mass percent of the partial cyclopentadecylidene dimethyl siloxane is 27.6 percent. In this example, the commercial product of the raw material is Hajing Polymer materials, Inc., Yunnan Hao Jing, Inc., under the trade name
PF0105。
C30-45 alkyl methicone and C30-45olefin were purchased from Guangdong Han dynasty style New materials Co., Ltd, under the trade name of oil-soluble silicone wax ZQ-050 as raw materials of the mixture.
Further, a mixture of cyclopentadimethylsiloxane and polydimethylsiloxane, C30-45 alkyl polymethylsiloxane and C30-45olefin are added and stirred until the mixture is dissolved, wherein the stirring speed is 1800-2300 rpm, and the stirring time is 5 min.
The mixture of cyclopentadecyldimethylsiloxane and polydimethylsiloxane was 10% by mass, wherein the cyclopentadecyldimethylsiloxane and the polydimethylsiloxane were 8.5% by mass and 1.5% by mass, respectively. In this example, the mixture of cyclopentadimethylsiloxane and polydimethylsiloxane was obtained from Cijing Polymer materials, Inc., Yunnan Kango, under the trade name "Jingjing
SR132。
Before the raw materials are added into the emulsifying pot, the tools used need to be sterilized, and water drops cannot be left on the tools such as the emulsifying pot.
102, adding the rest cyclopentadimethylsiloxane and the polydimethylsiloxane/vinyl polydimethylsiloxane cross-linked polymer into an emulsifying pot, and uniformly stirring and homogenizing.
Adding the rest cyclopentadimethyl siloxane and the polydimethylsiloxane/vinyl polydimethylsiloxane cross-linked polymer into an emulsifying pot, and uniformly stirring, wherein the stirring speed is 10-20 rpm, and the homogenizing speed is 1800 plus material 2300 rpm.
The sum of the mass percentages of the remaining cyclopentadecyldimethylsiloxane and the polydimethylsiloxane/vinyl polydimethylsiloxane crosspolymer was 53.65%, wherein the mass percentages of the remaining cyclopentadecyldimethylsiloxane and the polydimethylsiloxane/vinyl polydimethylsiloxane crosspolymer were 42.92% and 10.73%, respectively.
To this end, the percentages by mass of cyclopentadimethylsiloxane and of the remaining cyclopentadimethylsiloxanes in the mixture of the abovementioned partial cyclopentadimethylsiloxane, cyclopentadimethylsiloxane and polydimethylsiloxane amounting to 79.02%, were added in the abovementioned steps 101 and 102 in a separate step, and they were from different commercial products.
Preferably, the temperature is reduced to 45 ℃ or below, hydrogenated polyisobutene, polyglycerol-4 laurate, PEG-6caprylic/capric glycerides, water, tripeptide-1, acetyl hexapeptide-8, pentapeptide-3, tocopherol, ascorbyl tetraisopalmitate, squalane and essence are added, and the mixture is stirred and homogenized, wherein the stirring speed is 10-20 r/min.
In this example, hydrogenated polyisobutene, polyglycerol-4 laurate, PEG-6caprylic/capric glycerides, water, tripeptide-1, acetyl hexapeptide-8 and pentapeptide-3 were purchased as a mixture from Viqi scientific Co., Ltd, Dongguan, under the trade name of Kovar OA-1.7.
Tocopherol is obtained from Shandong Tian Cheng Biotech Co., Ltd, under the trade name
Natural vitamin E.
Ascorbyl tetraisopalmitate is available from Jiangsu Phoenix biomedical science and technology Limited under the trade name VC-IP.
Squalane is available from Claien chemical technology (Shanghai) Co., Ltd under the trade name plantarens Olive Squalane.
The perfume was purchased from Qihuadun daily perfume perfumes (Shanghai) Co., Ltd, under the trade name FH 3100409.
Preferably, silica is added and stirred uniformly, wherein the stirring speed is 10-20 rpm, and the homogenizing speed is 1800-.
In this example, silica is available from SUNG SAN INC CO., LTD under the trade name ECOZEN SS 38.
And 105, filtering and discharging to obtain the polypeptide anti-wrinkle essence.
And 106, sampling and detecting the prepared polypeptide anti-wrinkle essence, and transferring the material body to a standing room.
and step 109, selecting pills from the capsules, and packaging to obtain finished products. In this process, a prior art multi-channel electronic tablet counter is required.
It should be noted that the production temperature is normal temperature except for the temperature setting explicitly described in the above step.
Compared with the prior art, the polypeptide anti-wrinkle essence disclosed by the invention is based on cyclopentadimethylsiloxane and polydimethylsiloxane/vinyl polydimethylsiloxane cross-linked polymerization, is smooth in skin feel, free of greasy feel, fast to absorb and capable of bringing better experience feel; acetyl hexapeptide-8, tripeptide-1 and pentapeptide-3 are adopted, so that the tea is rich in various high-activity polypeptides, multiple targets block nerve signal conduction formed by wrinkles, dynamic fine lines can be quickly faded, a V face can be tightly shaped, and the problems of texture processes such as eye lines, raised lines, statutory lines and the like can be safely solved; the adopted tocopherol (vitamin E) and ascorbyl tetraisopalmitate have certain effect of eliminating free radicals, and reduce the oxidation of the free radicals to the collagen structure, thereby achieving the anti-wrinkle effect. The polypeptide anti-wrinkle essence disclosed by the invention has the characteristics of quick anti-wrinkle effect, easiness in absorption and no greasiness.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention.
Claims (10)
1. The polypeptide anti-wrinkle essence is characterized by comprising the following components: cyclopentadimethylsiloxane, dimethicone/vinyl dimethicone crosspolymer, dimethicone, hydrogenated polyisobutylene, polyglycerol-4 laurate, PEG-6caprylic/capric glycerides, water, tripeptide-1, acetyl hexapeptide-8, pentapeptide-3, tocopherol, C30-45 alkyl methicone, C30-45olefin, silica, ascorbyl tetraisopalmitate, squalane, and fragrance.
2. The polypeptide anti-wrinkle essence according to claim 1, which comprises, by mass: cyclopentasiloxane 79.02%, dimethicone/vinyl dimethicone crosspolymer 10.73%, dimethicone 1.5%, hydrogenated polyisobutene 2.5425%, polyglycerol-4 laurate 0.24%, PEG-6caprylic/capric glycerides 0.15%, water 0.06%, tripeptide-10.0006%, acetyl hexapeptide-80.0063%, pentapeptide-30.0006%, tocopherol 2%, C30-45 alkyl methicone 0.75%, C30-45 alkene 0.75%, silica 1.05%, ascorbyl tetraisopalmitate 0.5%, squalane 0.5%, and fragrance 0.2%.
3. A preparation method of the polypeptide anti-wrinkle essence is used for preparing the polypeptide anti-wrinkle essence of claim 1 or 2, and comprises the following steps:
adding part of cyclopentadimethyl siloxane into an emulsifying pot, stirring, heating, adding a mixture of cyclopentadimethyl siloxane and polydimethylsiloxane, C30-45 alkyl polymethyl siloxane and C30-45olefin, and stirring until the cyclopentadimethyl siloxane and the polydimethylsiloxane are dissolved;
adding the rest cyclopentadimethylsiloxane and the polydimethylsiloxane/vinyl polydimethylsiloxane cross-linked polymer into an emulsifying pot, and uniformly stirring and homogenizing;
cooling, adding hydrogenated polyisobutene, polyglycerol-4 laurate, PEG-6caprylic/capric glycerides, water, tripeptide-1, acetyl hexapeptide-8, pentapeptide-3, tocopherol, ascorbyl tetraisopalmitate, squalane and essence, stirring and homogenizing;
adding silica, stirring and homogenizing uniformly;
filtering and discharging to obtain the polypeptide anti-wrinkle essence.
4. The method for preparing the polypeptide anti-wrinkle essence according to claim 3, wherein a part of cyclopentadimethylsiloxane is put into an emulsifying pot, stirred at a speed of 10-20 rpm, and heated to 70 ℃.
5. The preparation method of the polypeptide anti-wrinkle essence as claimed in claim 3, wherein the mixture of cyclopentadimethicone and dimethicone, C30-45 alkyl methicone and C30-45olefin are added and stirred until dissolution, wherein the stirring speed is 1800-2300 rpm and the stirring time is 5 min.
6. The method for preparing the polypeptide anti-wrinkle essence as claimed in claim 3, wherein the rest cyclopentadimethylsiloxane and the polydimethylsiloxane/vinyl polydimethylsiloxane cross-linked polymer are added into an emulsifying pot, and the mixture is stirred and homogenized uniformly, wherein the stirring speed is 10-20 rpm, and the homogenizing speed is 1800 and 2300 rpm.
7. The method for preparing the polypeptide anti-wrinkle essence according to claim 3, wherein the temperature is reduced to 45 ℃ or below, hydrogenated polyisobutene, polyglycerol-4 laurate, PEG-6caprylic/capric glycerides, water, tripeptide-1, acetyl hexapeptide-8, pentapeptide-3, tocopherol, ascorbyl tetraisopalmitate, squalane and essence are added, and the mixture is stirred and homogenized, wherein the stirring speed is 10-20 r/min.
8. The method for preparing the polypeptide anti-wrinkle essence as claimed in claim 3, wherein silica is added and the mixture is stirred uniformly, wherein the stirring speed is 10-20 rpm, and the homogenizing speed is 1800-2300 rpm.
9. The preparation method of the polypeptide anti-wrinkle essence according to any one of claims 3 to 8, wherein the preparation method further comprises the following steps: sampling and detecting the prepared polypeptide anti-wrinkle essence, and transferring the material body to a standing room;
the polypeptide anti-wrinkle essence can be filled into capsules, and the pelleting temperature is controlled at 38-48 ℃.
10. The preparation method of the polypeptide anti-wrinkle essence according to claim 9, wherein the preparation method further comprises the following steps: drying in capsule at 21-25 deg.C and relative humidity of 45% or less;
selecting the capsules, and packaging to obtain the finished product.
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| CN202210760519.4A CN115025007A (en) | 2022-06-30 | 2022-06-30 | Polypeptide anti-wrinkle essence and preparation method thereof |
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| CN202210760519.4A Pending CN115025007A (en) | 2022-06-30 | 2022-06-30 | Polypeptide anti-wrinkle essence and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115998640A (en) * | 2022-10-31 | 2023-04-25 | 梅晔生物医药股份有限公司 | Sugar-resistant composition, essence and production method |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106726668A (en) * | 2016-11-19 | 2017-05-31 | 诺斯贝尔化妆品股份有限公司 | A kind of many peptidoliposome raw materials used in cosmetics |
| CN108272744A (en) * | 2018-04-26 | 2018-07-13 | 北京婼薇乐护肤品有限公司 | A kind of capsule Essence and the method for manufacturing the capsule Essence |
| CN111991338A (en) * | 2020-09-25 | 2020-11-27 | 珠海市新高生物科技研究院有限公司 | Formula of roe capsule essence |
| CN112220703A (en) * | 2020-11-12 | 2021-01-15 | 厦门鹰君药业有限公司 | Anti-wrinkle cosmetic composition and preparation method thereof |
| CN112716826A (en) * | 2021-02-26 | 2021-04-30 | 山东科思达美生物科技有限公司 | Polypeptide composition with long-acting wrinkle removing and skin elasticity improving functions |
| CN113440459A (en) * | 2021-03-24 | 2021-09-28 | 广州市迪笙生物科技有限公司 | Anti-wrinkle cream containing acetyl hexapeptide-8 and preparation method thereof |
-
2022
- 2022-06-30 CN CN202210760519.4A patent/CN115025007A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106726668A (en) * | 2016-11-19 | 2017-05-31 | 诺斯贝尔化妆品股份有限公司 | A kind of many peptidoliposome raw materials used in cosmetics |
| CN108272744A (en) * | 2018-04-26 | 2018-07-13 | 北京婼薇乐护肤品有限公司 | A kind of capsule Essence and the method for manufacturing the capsule Essence |
| CN111991338A (en) * | 2020-09-25 | 2020-11-27 | 珠海市新高生物科技研究院有限公司 | Formula of roe capsule essence |
| CN112220703A (en) * | 2020-11-12 | 2021-01-15 | 厦门鹰君药业有限公司 | Anti-wrinkle cosmetic composition and preparation method thereof |
| CN112716826A (en) * | 2021-02-26 | 2021-04-30 | 山东科思达美生物科技有限公司 | Polypeptide composition with long-acting wrinkle removing and skin elasticity improving functions |
| CN113440459A (en) * | 2021-03-24 | 2021-09-28 | 广州市迪笙生物科技有限公司 | Anti-wrinkle cream containing acetyl hexapeptide-8 and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115998640A (en) * | 2022-10-31 | 2023-04-25 | 梅晔生物医药股份有限公司 | Sugar-resistant composition, essence and production method |
| CN115998640B (en) * | 2022-10-31 | 2023-08-22 | 梅晔生物医药股份有限公司 | Sugar-resistant composition, essence and production method |
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