WO2008066038A1 - Method of using cosmetic and cosmetic - Google Patents

Abstract

It is intended to provide a method of using a cosmetic which provides an excellent immediate effect and is capable of significantly confirming an effect such as improvement of wrinkles, lift-up effect, improvement of clearness, hair growth or antiinflammation; and a cosmetic which can be prepared as an oil-based cosmetic while maintaining a moisturizing effect which is exhibited by a polysaccharide of white wood ear fungus and further can exhibits the above effect after a pressure treatment. The method of using a cosmetic of the invention comprises subjecting a cosmetic to a pressure treatment at 50 to 190 MPa for 15 minutes or longer while heating, and applying the cosmetic after the pressure treatment to the skin or hair within 8 hours after the pressure treatment. Further, the cosmetic of the invention is prepared by blending a polysaccharide of white wood ear fungus with polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether.

Description

 Specification

 How to use cosmetics and cosmetics

 Technical field

 [0001] The present invention relates to a method for using cosmetics, and more particularly, to a method for applying cosmetics, and cosmetics such as skin care cosmetics.

 Background art

 [0002] Skin care cosmetics such as lotions, creams, and emulsions are cosmetics that are applied directly to the skin (skin) of the human body. After applying skin care cosmetics, makeup cosmetics are applied as necessary. The

As such cosmetics, by treating a semi-finished cosmetic product or a finished cosmetic product for a certain period of time with an ultra-high pressure (3,000 kgf / cm ² or more), “cosmetics that stretch against the skin” and “shitsu” For example, it has a smooth, full-bodied feel, is less sticky, and is well-familiar to the skin ”·“ Moistness • Long-lasting moisturizing effect, long-lasting makeup, etc. It has been proposed to promote / improve the basic / essential functions / characteristics of cosmetics! /, Etc. (see Patent Document 1).

[0003] In addition, the white jellyfish polysaccharide extracted from the fruit body of white jellyfish is useful as a skin care cosmetic since it has an excellent moisturizing effect.

 For example, cosmetics containing water-soluble polysaccharides extracted from fruit bodies of white jellyfish and water-soluble polymers with nonionic derivative powers such as polyethylene glycolate, polyethylene oxide, and copolymers of ethylene glycololene and propyleneglycolole are proposed. (See Patent Document 2).

 Patent Document 1: Japanese Patent No. 2969365

 Patent Document 2: JP-A-2005-330257

 Disclosure of the invention

 Problems to be solved by the invention

[0004] However, although the cosmetics described in Patent Document 1 can improve and improve the basic and essential functions of the cosmetics-properties, , Regarding the effect of improving the transparency and the hair-growth effect, the immediate effect is insufficient, and it is difficult to check these effects remarkably.

 On the other hand, the white jellyfish polysaccharide is highly soluble in water, so it only dissolves in the water-soluble polymers exemplified above, and when it is prepared as an oily cosmetic such as make-up cosmetic, it does not dissolve or disperse uniformly. A malfunction occurs. Further, when the white jellyfish polysaccharide is used after being treated with ultrafine particles, the dispersibility is improved and the function as a dynamic polymer is reduced. Moreover, the white jellyfish polysaccharide does not dissolve in a hydrophobic solvent as it is, so that it is still difficult to prepare it as an oily cosmetic.

 [0005] Further, when using a white jellyfish polysaccharide as a skin care cosmetic, further improvement of the moisturizing effect is desired, and in particular, the improvement of wrinkle and the moisturizing effect when applied after pressure treatment are desired. Improvement is desired.

 The object of the present invention is excellent in immediate effect, skin firmness improvement effect, wrinkle improvement effect, lift-up effect, skin transparency improvement effect, skin moisturizing effect, whitening effect (skin color improvement effect), Hair growth effect (hair thickness improvement effect), hair gloss improvement effect, pore improvement effect, skin texture improvement effect, acne improvement effect, and anti-inflammatory effect can be remarkably confirmed It is to provide a method for using cosmetics.

 [0006] Another object of the present invention is that it can be prepared as an oily cosmetic while retaining the moisturizing effect expressed by the white jellyfish polysaccharide, and further, improves wrinkles after pressurization and moisturizes. It is to provide a cosmetic that can further improve the effect.

 Means for solving the problem

[0007] In order to achieve the above object, the method of using the cosmetic composition of the present invention comprises a cosmetic composition of 50 to 190M.

It is characterized by applying pressure treatment for 15 minutes or more with Pa, and applying the cosmetic after pressure treatment to the skin or hair within 8 hours after the pressure treatment.

 In the method for using a cosmetic according to the present invention, it is preferable that the cosmetic is heated to 10 to 50 ° C. in the pressure treatment.

[0008] In order to achieve the other objects described above, the cosmetic of the present invention is characterized by a white jellyfish polysaccharide and polio. The cosmetic of the present invention is preferably subjected to a pressure treatment at 50 to 190 MPa for 15 minutes or more,

Used to apply to skin or hair within 8 hours.

 The invention's effect

 [0009] In the method of using the cosmetic of the present invention, first, the cosmetic is pressure-treated at 50 to 190 MPa for 15 minutes or more. Then, the pressure-treated cosmetics improve skin firmness, wrinkle improvement effect, lift-up effect, skin transparency improvement effect, skin moisturizing effect, whitening effect, hair growth effect, hair gloss improvement It becomes an active state capable of imparting effects, pore improvement effect, skin texture improvement effect, double acne improvement effect, and anti-inflammatory effect.

 [0010] In the method of using the cosmetic of the present invention, the cosmetic is then applied to the skin or hair within 8 hours after the pressure treatment. Then, the applied cosmetic penetrates into the skin or hair while maintaining the active state. For this reason, the skin or hair is infused with active cosmetics to improve skin wrinkles, lift-up effect, transparency improvement effect, whitening effect, hair growth effect, anti-inflammatory effect, anti-acne effect, etc. Since the various effects described above appear immediately, these effects can be confirmed remarkably.

 [0011] Further, according to the cosmetic of the present invention, it can be prepared as an oily cosmetic while maintaining the moisturizing effect expressed by the white jellyfish polysaccharide. Furthermore, according to the cosmetics of the present invention, wrinkle improvement effect after pressure treatment, moisturizing effect, elasticity improvement effect, lift-up effect, pore improvement effect, skin texture improvement effect, transparency improvement Effects, hair growth effects, and hair shine improvement effects can be obtained.

 Brief Description of Drawings

 FIG. 1 is an image processing diagram in the vicinity of a head shot taken in Evaluation Test Example 4.

 FIG. 2 is an image processing diagram showing the three-dimensional curved surface shape of the face measured in Evaluation Test Example 4.

[Fig. 3] (a) to (c) are image processing diagrams of optical micrographs of damaged hair photographed for sensory evaluation of the degree of improvement in hair thickness with V and deviation.

 [FIG. 4] An image processing diagram of a photograph in the vicinity of the eyes taken for evaluation of the improvement of wrinkles!

 FIG. 5 is an image processing diagram of a half-face photograph taken in the evaluation of the improvement degree of pores.

FIG. 6 is an image processing diagram of a half-face photograph taken in the evaluation of the improvement in texture. [Fig. 7] (a) and (b) are image processing diagrams of a sample photograph taken in turbidity measurement.

 Embodiments of the Invention

[0013] Hereinafter, first, the method for using the cosmetic of the present invention will be described in detail.

 In the method of using the cosmetic according to the present invention, first, the cosmetic is pressure-treated at 50 to 190 MPa for 15 minutes or more.

 In the method for using the cosmetic of the present invention, the cosmetic does not include a semi-finished cosmetic product in the middle of manufacture, but includes only a finished cosmetic product after manufacture. In other words, the cosmetic of the present invention is intended for the pressure treatment of a finished cosmetic product after production, which is not related to the presence or absence of the pressure treatment during the production.

 [0014] Examples of such cosmetics include skin care cosmetics that are applied directly to the skin of a human body (including the face and body) to give the skin a smooth, moist feeling. included.

 Examples of skin care cosmetics include facial cleansing foams, lotions, creams, milky lotions, jewels, massages, beauty liquids (essences), lotions, knocks, sunscreens, and Siebin Grossions. In addition, the cosmetics of the present invention are mainly applied to the scalp for the purpose of hair cosmetics to be applied to hair such as tonics, shampoos, rinses and hair creams, hair loss prevention and hair growth promotion, for example, hair growth. Hair-growth cosmetics such as hair and hair-care agents, and hair dyes such as hair colors and hair manicures, and cosmetics containing powders such as liquid foundation and cream foundation are also included.

[0015] The cosmetic used in the method of using the cosmetic of the present invention is not particularly limited, but various dosage forms such as liquid, cream, jelly, emulsion, sol and gel are available. Can be appropriately selected. In addition, when the cosmetic is in a form capable of measuring the average particle diameter, such as powder, slurry, emulsion (including micelles), and dispersion, the average before pressure treatment is used. The particle diameter is preferably, for example, 0.;! To 10 m, and further 1 to 5 m as the median diameter. The median diameter can be measured by, for example, a laser diffraction / scattering type particle size distribution measuring apparatus. In addition, the above-described cosmetic has a viscosity (26 ° C) before pressure treatment of, for example, 0.1 to 50 Pa's (26 ° C), or 0.5 to 30 Pa-s ( 26 ° C) is preferred. Viscosity can be measured with a B-type viscometer (Brookfield viscometer) at 26 ° C.

[0016] Further, the cosmetic used in the method of using the cosmetic of the present invention contains a high molecular compound capable of imparting elasticity such as, for example, white jellyfish polysaccharide, carboxybule polymer, agar, collagen, and the like! /, The power S is suitable. If such a polymer compound is contained! /, The wrinkle improvement and the lift-up effect can be further improved. Note that the blending ratio of such a polymer compound is, for example, 0.001 to;% by weight with respect to the total amount of the cosmetic.

 [0017] The pressure treatment of the cosmetic is not particularly limited, and a known press method such as a direct pressure press method or an isotropic pressure press method may be used according to the dosage form or the treatment amount. Is possible. Preferably, an isotropic pressure pressing method (CIP), more preferably, an isostatic pressing method can be used. When pressure treatment is performed by a CIP method such as a hydrostatic pressure press method, for example, first, cosmetics are enclosed in a flexible bag (such as a heat seal bag), and then the flexible material in which the cosmetics are sealed. The functional bag is put into a pressure medium tank of a known isotropic pressure press machine (for example, a water tank of an isostatic press machine) and then pressed.

 [0018] In the pressure treatment, the cosmetic is applied at 50 to 190 MPa, preferably 70 to 150 MPa, more preferably 85 to 125 MPa for 15 minutes or more, preferably 20 minutes or more, usually 60. For example, the pressure is increased for 15 to 60 minutes, preferably 20 to 60 minutes, more preferably 25 to 50 minutes, and then returned to normal pressure. When the pressure is less than the lower limit or when the time is shorter than the lower limit, it is difficult to obtain sufficient effects of the present invention on the skin and hair because the average particle size of the cosmetic is too large. It becomes. On the other hand, when the pressure exceeds the above upper limit, the average particle size of the cosmetic (when the average particle size can be measured, the same applies hereinafter) becomes too small. It becomes difficult to obtain an immediate effect. In addition, even if the time has passed for 60 minutes or longer, no change in the effect is recognized, so the upper limit of the time is preferably 60 minutes from the economical viewpoint.

[0019] In the pressure treatment, the cosmetic is preferably heated to 10 to 50 ° C, more preferably 30 to 50 ° C, and particularly preferably 30 to 40 ° C. In the pressure treatment, if the cosmetic is heated in the above temperature range, the immediate effect of the excellent effect of the present invention described later is improved. That's the power S. If the cosmetic is heated at a temperature exceeding the above upper limit, the cosmetic condition may change, making it unsuitable for use.

[0020] The heating is performed, for example, by installing a heater such as a jacket heater on a known press machine (such as the above-described hydrostatic press machine) so that the temperature of the cosmetic is within the above temperature range. Set the heating temperature in the heater.

 By the pressure treatment as described above, the above cosmetics can improve the wrinkles, lift-up effect, transparency improvement effect, hair growth effect, anti-inflammatory effect, anti-acne effect, whitening effect, etc. It will be in the active state which can provide the effect of. The active state is a state in which a cluster of water molecules and component particles that have changed due to the pressure treatment can develop a self-restoring force to restore the state before the pressure treatment.

 [0021] In other words, the cosmetic after pressure treatment has an average particle size and viscosity that are reduced compared to the cosmetic before pressure treatment. For example, the cosmetic of the present invention has an average particle size of When the measurement is possible, the average particle diameter (median diameter) before the pressure treatment is, for example,;! ~ 80% smaller, preferably 10-50% smaller. More specifically, as the media diameter, if it is arranged, it will be in the form of 0.0 |; 10 111, or 0.05-5 111. Further, the viscosity (26 ° C) of the cosmetic material after the pressure treatment is, for example, 5 to 50% lower, preferably 10 to 30% lower. More specifically, for example, 0.5 to 5 Pa ′ s (26 ° C.) and 1 to 3 Pa ′ s (26 ° C.).

 [0022] In such a state, the cosmetic of the present invention gradually increases to an average particle diameter (median diameter) or viscosity before pressure treatment by self-restoring force immediately after application to the skin or hair. Restores (or changes more than that) to give the skin and hair firmness (tension, elasticity), thereby improving wrinkles, lift-up effect, transparency improvement effect, whitening effect The above-mentioned various effects such as hair-growth effect, anti-inflammatory effect, and anti-acne effect can be imparted.

[0023] Next, in the method of using the cosmetic of the present invention, the cosmetic after the pressure treatment is applied to the skin within 8 hours, preferably within 3 hours, more preferably within 1 hour after the pressure treatment. Or apply to hair.

If it is not applied within the above time, the active state of the cosmetic of the present invention will disappear. In other words, before the cosmetic of the present invention is applied to the skin or hair, it is restored to the state before the pressure treatment (or the state where the active state disappears more than that), and the excellent It becomes difficult to obtain an effect.

 [0024] The skin to which the cosmetic is applied is not particularly limited, and may be any part of the human skin.

 In order to apply the cosmetic of the present invention to the skin, the cosmetic after the pressure treatment may be applied to the skin by a method of normally applying the cosmetic. For example, the cosmetic after the pressure treatment is peeled off. Apply directly to the skin. The amount of application is not particularly limited, and if it is for one person, it is, for example, about 0.;! To 2 g although it depends on the size of the face.

 [0025] The hair to which the cosmetic is applied is not particularly limited, but is mainly scalp hair. In order to apply the cosmetic of the present invention to the hair, the cosmetic after pressure treatment is usually applied to the cosmetic. For example, the cosmetic after pressure treatment is applied directly to the hair.

 In this way, when the cosmetic is applied to the skin or hair within the above time after the pressure treatment, the cosmetic penetrates into the skin or hair while maintaining the activated state described above, The condition inside the hair is restored to the state before the pressure treatment, and the state changes more than that). For example, an emulsion in an activated state is in a state where the average particle diameter is gradually increased in viscosity. Then, the skin or hair swells due to the self-restoring power of the cosmetics, and is given a skin and hair. As a result, the effect of improving skin wrinkles, such as stretching of the hair wrinkles, and skin firmness are improved (skin Effects such as lift-up effect, transparency improvement effect that improves skin transparency by improving moisture retention, hair growth effect that enhances hair growth and promotes hair growth, rough skin after shaving (redness Anti-inflammatory effect that protects skin from troubles such as itchiness).

 [0026] Such an effect is manifested immediately after the cosmetic is applied to the skin or hair, and thereafter, after the cosmetic is maintained for a certain period of time in the active state described above, the active state of the cosmetic is When disappearing, the above effect disappears. More specifically, the above effect is manifested, for example, within 3 hours immediately after the cosmetic is applied to the skin or hair, and the duration of the effect is, for example, about 2 weeks at the longest. .

[0027] Next, the cosmetic of the present invention will be described in detail. The cosmetic of the present invention comprises a white jellyfish polysaccharide, polyoxybutylene polyoxyethylene,

 A white jellyfish polysaccharide is obtained by extracting a fruit body of a white jellyfish using water and / or a water-soluble solvent (for example, alcohols such as ethanol and propanol, and darikols such as ethylene glycol and propylene glycol) as an extraction solvent. You can get power S.

 [0028] Shiroki Fuku (Shiraki;) ^, 'Tremella mciiormis' is a mushroom belonging to the genus Shiroki Fuku genus, whose fruit body is jelly, shrinks when dry and revenges when wet.

 The extraction method is not particularly limited, and a known method is used. For example, 0.1 to 30 parts by weight of a white jellyfish fruit body is immersed in 100 parts by weight of the extraction solvent and extracted at room temperature to 100 ° C. for 0.5 to 24 hours. Thereafter, the white jellyfish polysaccharide is obtained by filtration or centrifugation.

 [0029] The white jellyfish polysaccharide thus obtained is a natural plant polysaccharide (natural plant polymer) having mannose in the main chain and xylose and glucuronic acid in the side chain. It is an acidic heteropolysaccharide containing at least% by weight. Its average molecular weight is approximately 1 million or more.

 Such a white jellyfish polysaccharide is commercially available, and such a commercially available product can also be used. Examples of commercially available products include “Tremoyist-TP” (manufactured by Nippon Seika Co., Ltd.).

 [0030]

 It is an alkylene oxide derivative of glycerin, specifically, polyoxypropylene, polyoxyethylene and polyoxybutylene force S, block copolymerization or random copolymerization with glyceryl ether. Preferably, polyoxypropylene, polyoxyethylene and polyoxybutylene are block-copolymerized in that order with glyceryl ether.

 [0031]

For example, using glycerin as an initiator, propylene oxide, ethylene oxide and It can be obtained by sequential addition polymerization of butylene oxide. In the Nore, the ratio of each component is, for example, 2 to 8 mol parts of polyoxypropylene (propylene oxide) and 5 to 11 mol of polyoxyethylene (ethylene oxide) per 1 mol part of glyceryl ether (glycerin). Parts, polyoxybutylene (butylene oxide); The average molecular weight (GPC method; standard polystyrene conversion) is, for example, 500 to 1400, preferably 776 to 1124. It is marketed and such a commercial item can also be used. Examples of commercially available products include “WILBRIDE (R) S-753” (manufactured by NOF Corporation). For example, from! To 200 parts by weight, preferably from 10 to 100 parts by weight, based on 100 parts by weight of the white jellyfish polysaccharide.

[0033] The cosmetic of the present invention can be formulated into various dosage forms such as liquid, cream, jelly, emulsion, sol and gel. In order to prepare the cosmetic of the present invention, different power depending on the dosage form, for example, a white jellyfish polysaccharide and a polyoxygenous component are blended in a water-soluble solvent.

[0034] Examples of the water-soluble solvent include water, for example, alcohols such as ethanol, propanol, and isopropanol. These may be used alone or in combination. Preferably, hydropower S is used.

 The blending ratio of each component varies depending on the dosage form. For example, for 100 parts by weight of the water-soluble solvent, for example, 0.000;! To 1 part by weight, preferably 0.01 to 0.2. The ether is, for example, 0.;! To 20 parts by weight, preferably; !! to 10 parts by weight.

[0035] In addition to the above ingredients, the cosmetic of the present invention can be blended with other moisturizing agents for improving the moisturizing property within a range that does not impair the excellent effects of the present invention. Such humectants include, for example, nonionic water-soluble polymers (eg, polyethylene glycol Nore, polyethylene oxide, copolymers of ethylene oxide and propylene oxide, etc.), anionic water-soluble polymers (eg, hyaluronic acid, xanthan gum, chondroitin sulfate, polyglutamic acid, polyaspartic acid, carboxymethyl cellulose), phosphorus Lipid (for example, phosphatidylcholine, phosphatidylethanolamine, phosphatidinoreserin, phosphatidinoreinositole, soy lecithin, egg yolk lecithin, castor lecithin, etc.), ceramide, polyhydric alcohol, monosaccharide, amino acids, betaine, urea, natural extract, Vitamins are listed. The mixing ratio of such a humectant is appropriately selected.

 [0036] Further, in the cosmetic of the present invention, in addition to the above components, known additives can be blended within a range that does not inhibit the excellent effects of the present invention. Examples of such additives include surfactants, antioxidants, UV absorbers, preservatives, bactericides, chelating agents, pH adjusters, exfoliating agents, anti-inflammatory agents, refreshing agents, and fragrances. Is mentioned. The blending ratio of such additive is appropriately selected.

 [0037] The cosmetic of the present invention contains a white jellyfish polysaccharide and polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether. In this way, by combining the highly water-soluble! / White jellyfish polysaccharide with polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether, various cosmetics such as aqueous cosmetics and oily cosmetics are compatible. be able to. Therefore, for example, the cosmetic of the present invention can be prepared as an oily cosmetic even though it contains a white jellyfish polysaccharide. Can exhibit excellent moisturizing effect

Yes

[0038] Therefore, the cosmetics of the present invention include, for example, facial cleansing foams, lotions, creams, milky lotions, gels, massages, beauty liquids (essences), lotions, knocks, sunscreens, shaving lotions, etc. Skin care cosmetics such as tonics, shampoos, rinses, hair creams, etc., hair cosmetics applied to hair such as tonics, shampoos, rinses, hair creams, etc. Hair growth and hair nourishing cosmetics applied to the scalp of hair, such as hair coloring, hair manicure and other hair coloring, such as lipstick, lip gloss, teak, concealer, foundation, mascara, eyeliner, eye shadow, deodorant Makeup cosmetics such as sunscreens and hair tics, It can be widely prepared as an oily cosmetic.

[0039] Furthermore, if the cosmetic of the present invention is applied to the skin or hair after the pressure treatment, the effect of improving wrinkles, moisturizing effect, improving elasticity, lift-up effect, improving pores, improving transparency Improving effect, hair-growth effect, and hair shine improvement effect can be expressed immediately. Next, the method for applying the cosmetic of the present invention to the skin or hair after pressure treatment will be described in detail.

 [0040] In this method, the cosmetic of the present invention is pressure-treated at 50 to 190 MPa for 15 minutes or more, and the cosmetic after pressure treatment is applied to the skin or hair within 8 hours after the pressure treatment. . When used in this method, the cosmetic of the present invention is in a form capable of measuring the average particle diameter, such as powder, slurry, emulsion (including micelles), and dispersion. For example, the average particle size before the pressure treatment is preferably 0.;! To lO ^ m, more preferably 1 to 5 m as a median size. The median diameter can be measured by, for example, a laser diffraction / scattering particle size distribution measuring apparatus. In addition, the cosmetic composition of the present invention has a viscosity (26 ° C) before pressure treatment, for example, 0.1 to 50 Pa's (26 ° C), and further 0.5 to 30 Pa's (26 ° C). C) is preferred. Viscosity can be measured with a B-type viscometer (Brookfield viscometer) at 26 ° C.

 [0041] The pressure treatment of the cosmetic is not particularly limited, and a known press method such as a direct pressure press method or an isotropic pressure press method may be used depending on the dosage form, the treatment amount, and the like. Is possible. Preferably, an isotropic press method, more preferably an isostatic press method can be used. The specific method of the pressure treatment by the hydrostatic pressure press method is the same as described above.

 In the pressure treatment, the cosmetic is applied at 50 to 190 MPa, preferably 70 to 150 MPa, more preferably 85 to 125 MPa for 15 minutes or more, preferably 20 minutes or more, usually 60 minutes or less. For example, pressurize for 15 to 60 minutes, preferably 20 to 60 minutes, more preferably 25 to 50 minutes, and then return to normal pressure. If the pressure or pressurization time during the pressurization process is out of the above range, the same problem as described above will occur.

[0042] Further, in the pressure treatment, the cosmetic is preferably heated to 10 to 50 ° C, more preferably 30 to 50 ° C, and particularly preferably 30 to 40 ° C. Effects obtained when the temperature during pressure treatment is set in the above range, problems that occur when the lower limit is not reached, and The pressure treatment method is the same as described above.

 By the pressure treatment as described above, the cosmetic of the present invention is in an active state capable of imparting the above-described various effects such as wrinkle improvement, lift-up effect, transparency improvement effect, hair growth effect and the like. . The active state is as described above.

 [0043] The average particle diameter after the pressure treatment of the cosmetic of the present invention is reduced with respect to the cosmetic before the pressure treatment. For example, the cosmetic of the present invention has an average particle diameter of When the measurement is possible, the average particle diameter (median diameter) before pressurization is, for example,! ~ 80% smaller, preferably 10-50% smaller More specifically, the median diameter is in the form of {circle around (0.0)}; 10 111; Further, the viscosity (26 ° C) of the cosmetic after the pressure treatment is, for example, 5 to 50% lower, preferably 10 to 30% lower, and more specifically, for example, 0.5 to 5 Pa 's (26 ° C), and !! to 3 Pa' s (26 ° C).

 [0044] The effects of the cosmetic of the present invention in such a state are as described above.

 Next, in this method, the cosmetic after the pressure treatment is applied to the skin or hair within 8 hours, preferably within 3 hours, more preferably within 1 hour after the pressure treatment. The troubles that occur when not applied within the above time are the same as described above.

[0045] Regarding the skin and hair to which the cosmetic of the present invention is applied, the application method and application amount to the skin, and the application method to the hair are all the same as described above. Thus, when the cosmetic of the present invention is applied to the skin or hair within the above time after the pressure treatment, the cosmetic of the present invention maintains the above-mentioned activated state while maintaining the above-mentioned activated state. Penetration into the skin and the inside of the hair or restoration to the state before the pressure treatment (or more changes). For example, an emulsion in an activated state is in a state where the average particle size gradually increases in viscosity. Then, the skin or hair swells due to the self-restoring power of the cosmetic, and is added with water and skin. As a result, the effect of improving skin wrinkles such as stretching of the hair wrinkles and the skin elasticity are improved (the skin is improved). Effect), for example, lift-up effect, transparency improvement effect that improves skin transparency by improving moisture retention, hair growth effect that promotes hair growth while adding gloss to hair, rough skin after shaving (redness, itching, etc. The anti-inflammatory effect that protects the skin from troubles) is expressed.

[0046] Such an effect is manifested immediately after the cosmetic is applied to the skin or hair, and then, after the cosmetic is maintained for a certain period of time in the active state described above, the active state of the cosmetic is When disappearing, the above effect disappears. More specifically, the above effect is manifested, for example, within 3 hours immediately after the cosmetic is applied to the skin or hair, and the duration of the effect is, for example, about 2 weeks at the longest. .

 Example

 [0047] Hereinafter, the present invention will be described more specifically with reference to formulation examples, evaluation test examples, examples and the like. However, the present invention is not limited to these descriptions.

 Formulation Example 1 (Preparation of emulsion)

[0048] [Table 1]

table"!

 Formulation Example 1: Emulsion>

 Ingredients Amount

 Component name

 Number (% by weight)

 1 Cetyl alcohol 1.00

 2 Sara beeswax 0.50

 3 Hydrogenated lanolin 2.00

 4 screen 5.00

 5 Hohono Oil 3.00

 6 Glycerin 5.00

 7 1, 3 Butylene glycol 5.00

 8 POE (10) mono-succinic acid ester 1.50

 9 Glyce Mouth Monostearate 1.00

 10 Carboxyvinyl polymer (1 wt% aqueous solution) 15.00

 11 Potassium hydroxide 0.10

 12 Paraben 0.25

 13 Tocolol acetate 0.20

 14 ε-Aminocaproic acid 0.10

 15 Purified water 60.35

Mouth 100.00 [0049] In the above formulation, cetyl alcohol, white beeswax, hydrogenated lanolin, squalene, jojoba oil and polyoxyethylene (hereinafter referred to as POE) (10) monooleate ester, glycerol monostearate, Noraben and tocopherol acetate were added and dissolved by heating to adjust the temperature to 70 ° C (hereinafter referred to as mixture a). On the other hand, daricerine, 1,3-butylene glycol, and carboxybule polymer (1 wt% aqueous solution) were added to purified water, dissolved by heating, and adjusted to 70 ° C (hereinafter referred to as mixture b). Subsequently, the mixture b was added to the mixture a and emulsified, and the emulsified particles were made uniform with a homomixer (hereinafter referred to as the mixture A). Further, potassium hydroxide previously dissolved in a part of purified water was added to the mixture A, stirred uniformly, and ε-aminocaproic acid was added during cooling to obtain an emulsion.

 [0050] Evaluation Test Example 1 (Pressure treatment and evaluation of emulsion: pressure change)

 (Pressure treatment)

 After putting 2 g of the emulsion of Formulation Example 1 into a small-capacity heat seal bag (Uniback A-4, produced by Nihonsha Co., Ltd.) and degassing, heat seal device (Desktop vacuum sealer for business use SQ-202, Sharp Corporation) And manufactured). The sealed small-capacity heat-sink bag is put together in the large-capacity heat-seal bag (Uniback F-4, manufactured by Nihon Co., Ltd.) for the number of times measured in each of the evaluation test examples described later, and the heat-seal device (same as above) Was used to seal a large-capacity heat seal bag, which was used as a sample.

 [0051] Thus, for each sample consisting of the emulsion of Formulation Example 1, when the processing pressure is less than lOOMPa, the hydrostatic press (water tank capacity: 8L, design pressure: max. 100MPa, design temperature: max. 75 ° C, body (Material: SUS630) When the processing pressure exceeds lOOMPa, press machine using cold isostatic pressing (CIP) (pressure tank capacity: 10L, design pressure: 0 to 500MPa, design temperature : 0-100 ° C). In addition, each sample should have a milk temperature of 32. The pressure was set to C, and pressure treatment was performed at 40 MPa, 50 MPa, 90 MPa, 130 MPa, 150 MPa, and 200 MPa for 30 minutes.

 [0052] Next, after 15 minutes from the end of the pressure treatment, an emulsion was applied to the face of each paneler and subjected to the following sensory evaluation. The results are shown in Table 2.

 (Sensory test)

6 healthy persons in their 30s to 60s (4 males and 2 females) are panelists. The face was washed with a commercially available face-washing foam, and moisture was wiped off with a towel. Next, each sample 0. Ig after the pressure treatment and each sample 0. Ig before the pressure treatment were applied to the face in the left and right half. From the application of the sample to the next morning, sensory evaluation was performed by self-assessment regarding the evaluation items described later.

 [0053] In Evaluation Test Example 1 and Evaluation Test Examples 2 and 3 to be described later, sensory evaluation was performed on the degree of improvement in skin firmness and the degree of improvement in skin wrinkles. In the sensory evaluation, the evaluation of each panelist is “best” (score: +3), “good” (score: +2), “slightly good” (score: +1), “no change” for each evaluation item. ”(Score: ± 0),“ slightly bad ”(score: 1),“ bad ”(score: 2) and“ worst ”(score: 3). Table 2 shows the number of panelists who made the evaluation for each evaluation level. Also, taking into account the level of evaluation and the number of panelists who performed the evaluation, we comprehensively judged whether there was any effect on the evaluation items. The method for determining the presence or absence of this effect was the same in the following evaluation test examples 2 and 3.

[0054] [Table 2]

[0055] Evaluation Test Example 2 (Emulsion pressure treatment and evaluation: change over time)

 Set each sampnore that has the emulsion power of Formulation Example 1 so that the temperature of the emulsion is 32 ° C, and pressurize each time for 10 minutes, 15 minutes, 30 minutes, 60 minutes, and 24 hours at a pressure of 90 MPa. Processed. After 15 minutes from the end of the pressure treatment, a sample was applied to the face of each paneler and subjected to the same sensory evaluation as in Evaluation Test Example 1. The results are shown in Table 3.

[0056] [Table 3] Intertemporal pressure treatment δ

 Hours 24 60

 Skin improvement degree skin

Good (3) 0+ Good (1) +

 Strange (0)

 Ya (and evil) 1+

 Tohei 8 14/18 18/1

 Efficacy Effectiveness Effectiveness Effectiveness Effectiveness Extremely extreme effect

 R o o o ο ο o Skin Improvement Degree> Too ο o ο ο

 Good () 3 0+ Somewhat good () 1+

 o ο o weird o (0) ο ο ο

 Slightly bad () 1- δ 8/8 Ql / Qi

 Total score 14/18 18/18

 + + + +

•

[0057] Evaluation Test Example 3 (Emulsion pressure treatment and evaluation: temperature change)

 Set each sample of the emulsion of Formulation Example 1 so that the temperature of the emulsion is 25 ° C 28 ° C 30 ° C 35 ° C 40 ° C 45 ° C 50 ° C and 55 ° C. Pressurized with pressure for 30 minutes. After 15 minutes from the end of the pressure treatment, a sample was applied to the face of each paneler and subjected to the same sensory evaluation as in Evaluation Test Example 1. The results are shown in Table 4.

[0058] [Table 4]

Evaluation Test Example 4 (Emulsion pressure treatment and evaluation: appearance evaluation)

Each sample consisting of the emulsion of Formulation Example 1 was set so that the temperature of the emulsion was 32 ° C., and pressurized at a pressure of 90 MPa for 30 minutes. After 15 minutes from the end of the pressurization process, apply the sample to the face of one paneler, and before the application and after each application, 1 hour, 3 hours and 5 hours, I took a photo of the neighborhood. The results are shown in Fig. 1. [0060] Also, at the same time as taking a picture near the eyes, before use (before application), after 1 hour of use (after 1 hour of application), and after 24 hours of use (after 24 hours of application), Each three-dimensional curved surface shape was measured.

 For 3D curved surface shape measurement, use the 3D shape measuring device "TRiDY-F" (manufactured by JFE Technoresearch Co., Ltd.), fix the paneler's jaw and forehead with a fixture, and then click the measurement button to measure. Started. Figure 2 shows the measurement results.

 [0061] In FIG. 2, in the enlarged view before and after use, the contour line after 1 hour of use is denser than the contour line before use, and thus a lift-up effect is exhibited after 1 hour of use. I found out.

 Evaluation Test Example 5 (Emulsion pressure treatment and evaluation: average particle size, viscosity)

 Each sample consisting of the emulsion of Formulation Example 1 was set so that the temperature of the emulsion was 32 ° C., and pressurized at a pressure of 90 MPa for 30 minutes. The average particle size and viscosity of the emulsion were measured before pressing and after 15 minutes, 1 hour, 2 hours, 3 hours and 24 hours from the end of the pressing process. The temperature of the emulsion at the time of viscosity measurement was 26 ° C. The results are shown in Table 5.

 [0062] For measurement of the average particle size, a sample prepared by diluting an emulsion with distilled water to 0.5% by weight was used. The average particle size is measured with a laser diffraction / scattering particle size distribution measuring instrument “LA-920 type” (manufactured by Horiba, Ltd.), and both the transmittance of laser light and tungsten light is measured in the sample measurement section. The amount was set to 70 to 95%, and the measurement was started after the transmittance was stabilized. The measurement result was a median diameter.

 [0063] [Table 5] Table 5

 Evaluation Test Example 5: Pressurization and Evaluation of Emulsion (Formulation Example 1)>

 Average particle size Viscosity (26 ° C)

 (Pa-s)

 Before pressure treatment 2.1913 1.10

 From pressure treatment

 After 15 minutes 2.145 1.05

 After 1 hour 2.168 1.08

 After 2 hours 2.415 1.31

 After 3 hours 2.845 1.48

After 24 hours 2.980 1.55 [0064] Formulation Example 2 (Preparation of Facial Wash Form A)

[0065] [Table 6] Table 6

 <Prescription Example 2: Face Wash Form A>

 Ingredients Amount

 Component name

 Number (% by weight)

 1 Steared rice cake 12.00

 2 Myristic acid 14.00

 3 Lauric acid 5.00

 4 Skull 1.00

 5 Potassium hydroxide 5.00

 6 Sorbitol 70 wt% aqueous solution 15.00

 7 Glycerin 10.00

 8 1, 3-Butylene glycol 10.00

 9 POE (20) Glyce Mouth Monostearate 2.00

 10 EDTA 0.10

 11 Fragrance 0.10

 12 Purified water 25.80

 + 100.00

[0066] In the above formulation, stearic acid, myristic acid, lauric acid, squalane and sorbitol 70% by weight aqueous solution, glycerin, 1,3-butylene glycol, POE (20) glycerol monostearate 80. Dissolve by heating. Kept at C. In advance, lithium hydroxide was dissolved in purified water, and the mixture of the dissolved components was added to the mixture and neutralized while stirring. After completion of the neutralization reaction, EDTA and a fragrance were added, and the mixture was cooled with stirring to obtain a face-washing foam A.

 [0067] Evaluation Test Example 6 (Pressurizing treatment and evaluation of face-wash form A)

 A sample was obtained in the same manner as the pressure treatment of Evaluation Test Example 1 except that the face washing foam A2g of Formulation Example 2 was used in place of the emulsion 2g of Formulation Example 1.

In this way, each sample consisting of the face-washing foam A of Formulation Example 2 was set so that the temperature force of the face-washing foam A was ¾2 ° C, and was pressurized at a pressure of 90 MPa for 30 minutes. Next, after 15 minutes from the end of the pressurization process, facial cleansing form A was applied to the face of each panel, and an evaluation test was performed. The same sensory evaluation as in Test Example 1 was performed.

[0068] As a result of the sensory evaluation, all of them showed the best evaluation in terms of improvement in skin firmness and skin wrinkle.

 Formulation Example 3 (Preparation of lotion)

[0069] [Table 7] Table 7

 <Prescription Example 3: Lotion>

 Ingredients Amount

 Component name

 Number (Ritsuka. / O)

 1 1, 3 Butylene glycol 5.00

 2 Glycerin 5.00

 3 Screen 0.10

 4 POE (20) sorbitan monolaurate 0.50

 5 POE (15) lauryl alcohol ether 0.50

 6 Ethanol 10.00

 7 Tocopherol acetate 0.10

 8 Paraben 0.15

 9 Aloe extract 1.00

 10 Fragrance 0.10

 11 Purified water 77.55

 Total 100.00

[0070] In the above formulation, 1,3-butylene glycol, glycerin, and aloe extract were added to purified water and dissolved (hereinafter referred to as mixture c). On the other hand, squalene, PO E (20) sorbitan monolaurate, POE (15) lauryl alcohol ether, tocopherol acetate, paraben, and fragrance were added to ethanol and dissolved (hereinafter referred to as mixture d). Next, the mixture d was added to the mixture c and solubilized to obtain a lotion.

 [0071] Evaluation Test Example 7 (Pressure treatment and evaluation of lotion)

 A sample was obtained in the same manner as the pressure treatment of Evaluation Test Example 1 except that 2 g of the skin lotion of Formulation Example 3 was used instead of 2 g of the emulsion of Formulation Example 1.

Thus, each sample made of the skin lotion of Formulation Example 3 was set so that the temperature of the skin lotion was 32 ° C., and was pressurized for 30 minutes at a pressure of 90 MPa. Next, after 15 minutes from the end of the pressure treatment, lotion was applied to the face of each paneler, and the same sensory evaluation as in Evaluation Test Example 1 was performed. It was used for.

 [0072] As a result of the sensory evaluation, all of them showed the best evaluation in terms of improvement in skin firmness and skin wrinkle improvement.

 Formulation Example 4 (Preparation of Cream A)

[0073] [Table 8] Table 8

 <Formulation Example 4: Cream A>

 Ingredients Amount

 Component name

 Number (% by weight)

 1 Stearyl alcohol 6.00

 2 Stearic acid 2.00

 3 Hydrogenated lanolin 4.00

 4 screen 10.00

 5 Cetyl octanoate 10.00

 6 Diglycerin 3.00

 7 1,3 Butylene glycol 7.00

 8 POE (25) Cetyl alcohol ether 3.00

 9 Monosoxalic acid 2.00

 10 Norraben 0.25

 11 Tocopherol acetate 0.20

 12 Collagen (0.1 wt./. Aqueous solution) 1.00

 13 Purified water 51.55

 Total 100.00

[0074] In the above formulation, stearyl alcohol, stearic acid, hydrogenated lanolin, squalane, cetyl octanoate and POE (25) cetyl alcohol ether, monostearic acid ester, paraben, tocopherol acetate were added and dissolved by heating. The temperature was adjusted to ° C (hereinafter referred to as mixture e). On the other hand, diglycerin and 1,3-butylene glycol were added to purified water, dissolved by heating, and adjusted to 70 ° C (hereinafter referred to as mixture f). Subsequently, the mixture f was added to the mixture e for emulsification, the emulsified particles were homogenized with a homomixer, and collagen (0.1 wt% aqueous solution) was added during cooling to obtain cream A.

 [0075] Evaluation Test Example 8 (Pressure treatment and evaluation of cream A)

A sample was obtained in the same manner as in the pressure treatment of Evaluation Test Example 1 except that 2 g of the cream A of Formulation Example 4 was used instead of 2 g of the emulsion of Formulation Example 1. Thus, each sample consisting of the cream of Formulation Example 4 was set so that the temperature of the cream was 32 ° C., and was pressurized for 30 minutes at a pressure of 90 MPa. Next, after 15 minutes from the end of the pressurizing treatment, it was applied to the face of each paneler and subjected to the same sensory evaluation as in Evaluation Test Example 1.

 [0076] As a result of the sensory evaluation, all of them showed the best evaluation in terms of the improvement of skin firmness and the improvement of skin wrinkles.

 Formulation Example 5 (Preparation of Giel)

[0077] [Table 9]

Table 9

 <Prescription Example 5: Di: Le>

 Compounding amount

 Component name

 Number (% by weight)

 1 Dipropylene glycol 6.00

 2 PEG 1 500 2.00

 3 Carboxyvinyl polymer 0.50

 4 POE (15) O'Reil Arce Luthel 1.00

 5 Potassium hydroxide 0.25

 6 Paraben 0.15

 7 Tocopherol acetate 0.10

 8 Hyaluronic acid 0.10

 9 Purified water 89.90

 100.00

Based on the above formulation, carboxybulbomer was added to purified water and dissolved uniformly (hereinafter referred to as mixture g). Next, dipropylene glycol, PEG 1500, POE (15) oleyl alcohol ether, paraben, and tocopherol acetate were added to the mixture g to make it uniform (hereinafter referred to as mixture h). Further, potassium hydroxide previously dissolved in purified water was added to the mixture h, and the mixture was uniformly stirred and neutralized (hereinafter referred to as mixture i). Then, mix i in advance. Diels were obtained by adding hyaluronic acid that was uniformly dissolved in water to make it uniform.

[0079] Evaluation test example 9 (pressurization treatment and evaluation of jewel)

 A sample was obtained in the same manner as the pressure treatment of Evaluation Test Example 1 except that 2 g of Giel of Formulation Example 5 was used instead of 2 g of the emulsion of Formulation Example 1.

 In this way, each sample consisting of the jewels of Formulation Example 5 was subjected to pressure treatment at a pressure of 90 MPa for 30 minutes while setting the temperature of the jewels to be 32 ° C. After 15 minutes from the end of the pressure treatment, it was applied to the face of each paneler and subjected to the same sensory evaluation as in Evaluation Test Example 1.

[0080] As a result of the sensory evaluation, all of them showed the best evaluation in terms of the improvement of skin firmness and the improvement of skin wrinkles.

 Formulation Example 6 (Preparation of serum A)

[0081] [Table 10]

Table 1 0

 <Prescription Example 6: Essence A>

 Ingredients Amount

 Component name

 Number (% by weight)

 1 Sorbi! LE 8.00

 2 1, 3-Butylene glycol 5.00

 3 PEG 1 500 7.00

 4 Hiaryrelon 0.10 0.10

 5 Ethanol 7.00

 6 POE 5) oleyl alcohol ether 1.00

 7 Olive oil 0.10

 8 Queen Seed 0.10

 9 Tocopherol acetate 0.10

 10 Paraben 0.15

 11 Purified water 71.45

 π 100.00

In the above formulation, sorbitol, 1,3-butylene glycol, ΡΕG 1500, hyaluronic acid and quince seed were added to purified water and dissolved uniformly (hereinafter referred to as mixture j and To do). On the other hand, POE oleyl alcohol ether, olive oil, tocopherol acetate and paraben were added to ethanol and dissolved uniformly (hereinafter referred to as mixture k). Subsequently, the mixture k was added to the mixture j and mixed uniformly to obtain a cosmetic liquid A.

[0083] Evaluation Test Example 10 (Coating and evaluation of serum A)

 A sample was obtained in the same manner as the pressure treatment of Evaluation Test Example 1 except that the cosmetic liquid A2g of Formulation Example 6 was used instead of the emulsion 2g of Formulation Example 1.

 In this way, each sample consisting of the cosmetic liquid A of Formulation Example 6 was set so that the temperature of the cosmetic liquid A was 32 ° C., and was pressurized for 30 minutes at a pressure of 90 MPa. After 15 minutes from the end of the pressurizing treatment, it was applied to the face of each paneler and subjected to the same sensory evaluation as in Evaluation Test Example 1.

[0084] As a result of the sensory evaluation, all of them showed the best evaluation in terms of improvement in skin firmness and skin wrinkle.

 Formulation Example 7 (Preparation of Hair Cream A)

[0085] [Table 11]

table"

 <Prescription Example 7: Hair Cream A>

 Ingredients Amount

 Component name

 Number (% by weight)

 1 Liquid paraffin 10.00

 2 Petrolatum 15.00

 3 Sara honey bees 2.00

 4 Olive oil 5.00

 5 Tokovol acetate 0.20

 6 Paraben 0.20

 7 Purified water 62.05

 8 Carboxyvinyl polymer 0.15

 9 Glycerin 5.00

 10 Potassium hydroxide 0.10

 11 Fragrance 0.30

Mouth § + 100.00 [0086] In the above formulation, liquid paraffin, petrolatum, white beeswax, olive oil, tocopherol acetate and paraben were heated and dissolved to adjust to 70 ° C (hereinafter referred to as mixture 1). Carboxybule polymer and glycerin were added to purified water, dissolved by heating, and adjusted to 70 ° C (hereinafter referred to as mixture m). Next, the mixture m was added to the mixture 1 and emulsified, and the emulsified particles were homogenized with a homomixer (hereinafter referred to as the mixture n). Furthermore, potassium hydroxide previously dissolved in purified water was added to the mixture n, and the mixture was cooled with uniform stirring (hereinafter referred to as a mixture). Then, the mixture o was cooled with stirring, and a fragrance was added at 50 ° C. to obtain a hair tarme.

 [0087] Evaluation Test Example 11 (Pressure treatment and evaluation of hair cream A)

 A sample was obtained in the same manner as the pressure treatment of Evaluation Test Example 1, except that the hair cream A2g of Formulation Example 7 was used instead of the emulsion 2g of Formulation Example 1.

 In this way, a sample consisting of hair cream A of Formulation Example 7 was set so that the temperature of hair cream A was 32 ° C., and pressure-treated at a pressure of 90 MPa for 30 minutes. After 15 minutes from the end of the pressurization treatment, it was applied to the hair of each paneler and subjected to sensory evaluation.

[0088] Formulation Example 8 (Preparation of hair restorer A)

[0089] [Table 12]

Table 1 2

 Prescription Example 8: Hair restorer A>

 Ingredients Amount

 Component name

 Number (% by weight)

 1 Ethanol 60.00

 2 Glycerin 3.00

 3 Assembly extract 1.00

4 Vitamin B ₆ 0.50

 5 Tocophere acetate mouthpiece 0.20

 6 PO E (20) sorbitan monolaurate 0.50

 7 Fragrance 0.30

 8 Purified water 34.50

 = 4- 100.00

[0090] In the above formulation, glycerin, assembly extract, vitamin Β6, tocopherol acetate, ΡΟΕ (20) sorbitan monolaurate and fragrance are added to ethanol and dissolved, and then purified water is added to dissolve and hair growth Agent was obtained.

 Evaluation Test Example 12 (Pressure treatment and evaluation of hair restorer A)

 A sample was obtained in the same manner as in the pressure treatment of Evaluation Test Example 1 except that the hair restorer A2 g of Formulation Example 8 was used instead of 2 g of the emulsion of Formulation Example 1.

[0091] Thus, the sample comprising the hair restorer A of Formulation Example 8 was set so that the temperature of the hair restorer A was 32 ° C, and was pressurized for 30 minutes at a pressure of 90 MPa. After 15 minutes from the end of the pressurization treatment, it was applied to the scalp of each paneler and subjected to sensory evaluation. As a result, all of them improved the gloss of hair and the effect of promoting hair growth.

 Formulation Example 9 (Preparation of serum B)

[0092] [Table 13] Table 1 3

 <Prescription Example 9: Essence B>

 Ingredients Amount

 Component name

 Number

 1 Glyceryl monostearate 0.70

 2 Sorbitan sesquioleate 1.20

 3 Stearic acid 0.30

 4 Ceramide 0.05

 5 Skulang 3.50

 6 Glycyrrhetinic acid ester 0.05

 7 Cholesteryl hydroxystearate1.00

 8 Meadow foam oil 6.00

 9 Jojoba oil 3.50

 Lauroyl glutamic acid

 10 1.00

 Di (octyldodecyl novitos 亍 aril nobehenyl)

 11 Sorbitan sesquioleate 0.50

 12 Polyglycerin condensed fatty acid ester 1.00

 13 d— (5— 卜 Coferrole 0.15

 14 Raven 0.20

 15 Purified water 56.85

 16 Agar 0.25

 17 Sucrose fatty acid ester 0.20

 18 1 3 Butylene gel recall 6.00

 19 Glycerin 4.50

 20 Trimethylglucin 1.50

 POB (3) POE (8) POP (5) Glyceryl Tell

 21 1.00

 (`` Wilbride S-753J)

 22 White jellyfish polysaccharide (1% aqueous solution) 10.00

 23 Silicone resin 0.05

 24 Hyaluronic acid (0.5% aqueous solution) 0.50

 ^-100.00

[0093] In the above compounding recipe, component numbers;! To 14 were mixed, dissolved by heating, and adjusted to 80C. On the other hand, after adding component number 1623 to component number 15, dissolving by heating, adjusting this to 80 ° C, adding the mixture of component numbers;!-14, and emulsifying, then homogenizer. The emulsified particles were made uniform while stirring. Subsequently, the emulsion was cooled to 50 ° C., component number 24 was mixed, and the mixture was stirred and cooled to 40 ° C. to prepare cosmetic liquid B.

[0094] Evaluation Test Example 13 (Pressurization treatment and evaluation of serum B) (Pressure treatment)

 A sample was obtained in the same manner as the pressure treatment of Evaluation Test Example 1 except that the cosmetic liquid B2g of Formulation Example 9 was used in place of the emulsion 2g of Formulation Example 1.

 In this way, each sample consisting of the cosmetic liquid B of Formulation Example 9 was subjected to pressure treatment under the following conditions (i) to (iii).

 (i) The treatment time was fixed at 30 minutes, the treatment temperature was fixed at 32 ° C, and the treatment pressure was set at 40, 50, 90, 150, 190 and 200 MPa.

 (ii) The treatment pressure was fixed at 90 MPa, the treatment temperature was fixed at 32 ° C, and the treatment time was set to 10 minutes, 15 minutes, 30 minutes, 60 minutes and 24 hours.

 (iii) The processing pressure is fixed at 90 MPa, the processing time is fixed at 30 minutes, and the processing temperatures are 25, 28, 30, 35, 40, 45, 50 and 55. Each temperature of C was set.

 [0095] Next! /, On the sample pressure-treated under the conditions (i) to (iii) above! /,

 (1) lift-up effect, (2) improvement in hair thickness, (3) improvement in hair gloss, (4) improvement in pores, (5) improvement in skin texture, and (6) skin A sensory evaluation was conducted on the degree of improvement in transparency.

 (1) Lift-up effect

 Five women in their 40s to 50s were panelists, and the face of each paneler was washed with a commercially available face-wash foam, and the moisture was wiped off with a towel. Next, apply 2 g of the cosmetic liquid BO. 2 in Formulation Example 9 that has been subjected to the prescribed pressure treatment to the left or right face of each paneler, and leave nothing on the other face. And left until the next day. The next day, the skin condition of each panel was observed and sensory evaluation of the lift-up effect was performed.

[0096] The lift-up effect was evaluated in the same manner as in Evaluation Test Example 4 by taking a photograph of the vicinity of each paneler's head and measuring the three-dimensional curved surface shape as described above. In other words, the contour line force around the eyes is observed to see if it is denser than before applying the serum, and to what extent the change is, and “improvement” (+2), “slightly improvement” (+ 1), “No change” (± 0), “Slightly worse” (—1), and “Deteriorated” (1 2). In addition, the scores of the five panelists were totaled to comprehensively evaluate the lift-up effect. The overall evaluation criteria are “no effect” when the total score is less than 10% of the full score (10 points), 10% or more “Slightly effective” when less than 40%, “effective” when 40% or more and less than 80%, and “very effective” when 80% or more. The evaluation results are shown in Tables 14 to 16:

[Table 14]

sS§. '¾ 律 眯 ¾ 律 体

Table 15]

Table 15

 Evaluation test example 13 (1) (ii): Pressurization treatment and evaluation of essence B (formulation example 9): Change over time> Treatment pressure: 90 MPa. Treatment temperature: 32¾

 Processing time Pressure treatment 10 minutes 15 minutes 30 minutes ― 60 minutes _ 24 hours None _ Lift up effect>

 Improved (+2) 0 0 5 5 4 0 Slightly improved (+1) 1 2 0 0 1 1 No change (± 0) 4 3 0 0 0 4 Slightly degraded (-1) 0 0 0 0 0 0 Degraded (- 2) 0 0 0 0 0 0 Total score 1/10 2/10 10/10 10/10 9/10 1/10

Slightly quite abandoned Extremely somewhat effective Effective Effective Active Effective Effective

[0100] From Table 14, the lift-up effect is extremely effective when the pressure of the pressure treatment is 50 190 MPa. If the pressure is outside the above range, the lift-up effect will be slightly reduced. I got it. From Table 15 and Table 16, the lift-up effect is extremely effective when the processing time force for pressure treatment is ¾0 minutes or more, and extremely effective when the processing temperature is 2850 ° C. I found out that

[0101] (2) Improvement of hair thickness As the hair, human hair (Burelux Co., Ltd., 250 g, 30 cm) obtained by bleaching (hereinafter referred to as damaged hair) was fixed on a glass slide. Next, the surface state and thickness of the damaged hair were photographed with an optical microscope (BX60, manufactured by Olympus Corporation) and measured. Next, the hair on the slide glass was coated with the cosmetic liquid B of Formulation Example 9 that had been subjected to a predetermined pressure treatment, and left for 24 hours. After standing, the surface condition and thickness of the hair on the slide glass were photographed and measured with an optical microscope (BX60) in the same manner as before application, and compared with the measurement results before application of serum. Tables 17 to 19 show the difference (mm) between the measurement result of the diameter (mm) of the damaged hair and the measurement result before applying the cosmetic liquid.

[Table 17]

D

 Table 1 7

 Evaluation test example 13 (2) (i): Pressurization treatment and evaluation of serum B (formulation example 9): Pressure change> Treatment time: 30 minutes, Treatment temperature: 32¾

 Processing pressure (MPa) Pressure treatment

 Not applied

40 50 90 150 190 200 None

 <Improvement of hair thickness>

 Damaged hair thickness (mm) 0.085 0.090 0.095 0.095 0.095 0.085 0.085 0.080 Increase after treatment (mm) 0.005 0.010 0.015 0.015 0.015 0.005 0.005 ―

Slightly effective Extremely extremely Slightly effective Yes Effective Effective Effective Effective Yes

Table 1 8

 <Evaluation test example 13 (2) (ii): Pressurization and evaluation of serum B (formulation example 9): change over time> Processing pressure: 90 MPa. Processing temperature: 32 ° C

 Processing time Pressure treatment

 Not applied

10 minutes 15 minutes 30 minutes 60 minutes 24 hours None Degree of improvement in hair thickness>

Damaged hair thickness (mm) 0.085 0.090 0.095 0.095 0.095 0.085 0.080 Increase after treatment (mm) 0.005 0.010 0.015 0.015 0.015 0.005 ― Slightly effective Extremely extremely slightly effective Yes Active Effective Effective Effective

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[0105] Regarding the effect of improving hair thickness, from Table 17, it is effective when the pressure of the pressure treatment is 50 to 190 MPa, and if it is out of the above range, the extent of the effect of improving hair thickness The power was slightly lower. Moreover, the hair thickness improvement effect is effective (effective) from Table 18 and Table 19 when the treatment time is 15 minutes or more, and when the treatment temperature is 30 to 50 ° C. It was found to be extremely effective.

[0106] Further, images of damaged hair taken with an optical microscope are shown in Figs. 3 (a) to 3 (c). Fig. 3 (a) ~ All images shown in Fig. 3 (c) have the same magnification. The diameter of the damaged hair is 0.080 mm when the serum is not applied (Fig. 3 (a)), and when the serum is applied without pressure treatment (Fig. 3 (b)). 0.085 mm, when applying a cosmetic liquid that has been subjected to pressure treatment (treatment pressure 90 MPa, treatment temperature 32 ° C, treatment time 30 minutes) (Fig. 3 (c)), At once.

 [0107] (3) Improvement of hair gloss

 As hair, normal hair (Buelux Co., Ltd., human hair black hair, 20g, 15cm) and bundling damaged hair (bleached from the above normal hair) were used. After the bundle was washed with water, the moisture was gently wiped off. Next, the essence B of Formulation Example 9, which had been subjected to a predetermined pressure treatment, was applied to each bundle of hairs and allowed to stand for 24 hours. After standing, the hair bundle was washed again with water, thoroughly wiped off moisture, and then dried with a dryer. After drying, sensory evaluation was performed on the degree of gloss of the hair bundle.

 [0108] The evaluation of the degree of improvement of gloss was performed by visual judgment of five specialist referees based on the gloss of normal hair to which no cosmetic liquid was applied. Also, as a result of visual judgment, gloss improvement is “very high” (+3), “high” (+2), “slightly high” (+1), “no change” (± 0), “slightly low” “(1)”, “less” (1), and “very few” (1 3). In addition, the scores of the five referees were totaled to comprehensively evaluate the effect of improving hair gloss. The overall evaluation criteria are “no effect” if the total score is less than 10% of the full score (15 points), “somewhat effective” if the total score is 10% or more and less than 40%, 40% or more When it was less than 80%, “effective”, and when it was 80% or more, “very effective”. The evaluation results are shown in Tables 20-22.

[0109] [Table 20] Table 20

 Evaluation test example 13 (3) (i): Pressurization and evaluation of serum B (formulation example 9): Pressure change> Processing time: 30 minutes. Processing temperature: 32 ° C

 Processing pressure (MPa) Pressure treatment D¾2

 Improvement of hair gloss> 40 50 90 150 190 200 None

[Normal hair]

 Very high (+3) 0 0 0 0 0 0 0 High (+2) 0 2 5 5 5 0 0 Slightly high (+1) 2 3 0 0 0 2 2 No change (± 0) 3 0 0 0 0 3 3 Slightly less (-1) 0 0 0 0 0 0 0 Less (-2) 0 0 0 0 0 0 0 Very few (-3) 0 0 0 0 0 0 0 Total score 2/15 7/15 10 / 15 10/15 10/15 2/15 2/15 Overall evaluation Somewhat effective Effective Effective Effective Effective Somewhat effective Somewhat effective

[Damaged hair]

Very high (+3) 0 1 3 2 1 0 0 High (+2) 0 3 2 3 4 0 0 Slightly high (+1) 2 1 0 0 0 2 2 No change (± 0) 3 0 0 0 0 3 3 Slightly less (-1) 0 0 0 0 0 0 0 Less (-2) 0 0 0 0 0 0 0 Very few (-3) 0 0 0 0 0 0 0 Total score 2/15 10/15 13 / 15 12/15 11/15 2/15 2/15 Comprehensive evaluation Somewhat effective Effective Very effective Very effective Effective Somewhat effective Somewhat effective

Evaluation test example 13 (3) (ii): Pressurization treatment and evaluation of essence B (Prescription Example 9): Change over time> Treatment pressure: 90 MPa, Treatment temperature: 32¾ Treatment time Pressure treatment

<Improvement of hair gloss> 10 minutes 15 minutes 30 minutes 60 minutes 24 hours None

[Normal hair]

 Very high (+3) 0 0 0 0 0 0 High (+2) 0 1 4 5 3 0 Slightly high (+1) 2 4 1 0 2 2 No change (± 0) 3 0 0 0 0 3 Slightly low (-1) 0 0 0 0 0 0 Less (-2) 0 0 0 0 0 0 Very little (-3) 0 0 0 0 0 0 Total score 2/15 6/15 9/15 10/5 8 / 15 2/15 Comprehensive evaluation Somewhat effective Effectiveness Effective Effectiveness Somewhat effective

[Damaged hair]

 Very high (+3) 0 0 4 5 2 0 High (+2) 0 2 1 0 3 0 Slightly high (+1) 2 3 0 0 0 2 No change (soil) 3 0 0 0 0 3 Slightly low (-1) 0 0 0 0 0 0 Less (-2) 0 0 0 0 0 0

_ Very few _ (-3) 0 _0 0 0 0 0 _ Total score 2/15 7/15 14/15 15/15 12/15 2/15 Comprehensive evaluation Slightly effective Very effective Very effective Very effective Very effective Somewhat effective

[0112] According to Table 20, the effect of improving hair shine is effective when the pressure of the pressure treatment is 50 to 190 MPa, and if it is outside the above range, the degree of improvement of hair shine is slightly higher. The power that can be lowered has been reduced. In addition, Table 21 and Table 22 show that the effect of improving hair gloss is effective when the treatment time is 15 minutes or more, and is effective when the treatment temperature is 30 50 ° C. Power, ivy.

[0113] (4) Improvement of pores Five women in their 40s to 60s were panelists, and the face of each paneler was washed with a commercially available face-wash foam and wiped with a towel. Next, the state of pores on the face of each panel was photographed with a microscope (Charm Lite Stand III, Moritex Co., Ltd.). After photographing, the face of each paneler was applied with the beauty liquid B of Formulation Example 9 that had been subjected to a predetermined pressure treatment, and was left until the next day. On the next day, the state of the pores on the face of each paneler was photographed again with the above-mentioned microscope, and the sensory evaluation of the improvement degree of the pores was performed by comparing with the photograph before applying the cosmetic liquid.

 [0114] The comparison of the condition of the pores was conducted by five specialist referees, and the condition of the pores was “improved” (+ 2), “slightly improved” (+1), “no change” (± 0), The evaluation was made on a five-point scale (“1”) and “Deteriorated” (1 2). In addition, for the evaluation of each panel, the scores of the five panelists were totaled, and the scores obtained by each panel were totaled to comprehensively evaluate the pore improvement effect. For example, if all five referees rated “Improved” for one paneler, the paneler's score would be (+ 2) X 5 = 10 points. Since there are five panelists, the total score of all panelists is a maximum of 50 points.

 [0115] The overall evaluation criteria are “no effect” when the total score (50 points) of 5 panelists is less than 10%, and when the score is 10% or more and less than 40% “Slightly effective”, “effective” when 40% or more and less than 80%, and “very effective” when 80% or more. The results are shown in Tables 23-25.

[0116] [Table 23]

Table 23

 Evaluation test example 13 (4) (i): Pressurization treatment and evaluation of serum B (Prescription Example 9): Pressure change> Treatment time: 30 minutes, Treatment temperature: 32 ° C

 Processing pressure (MPa) Pressure treatment

40 50 90 150 190 200 None

<Improvement of pores>

Paneler 1 0 5 10 8 10 7 2 Paneler 2 4 10 7 10 6 10 1 Paneler 3 3 7 10 9 9 6 1 Paneler 4 3 8 10 10 10 9 1 Paneler 5 4 5 10 7 10 5 0 Total score 14/50 35/50 47/50 44/50 45/50 37/50 5/50 Comprehensive evaluation Slightly effective Effective Very effective Extremely effective Extremely effective Effective slightly

Table 24

 <Evaluation test example 13 (4) (ii): Pressurization treatment and evaluation of essence B (Prescription example 9): Change over time> Treatment pressure: 90 MPa, treatment temperature: 32 ° C Treatment time Pressure treatment

10 minutes 15 minutes 30 minutes 60 minutes 24 hours None Improvement of pores>

Paneler 1 1 6 10 8 10 2 Paneler 2 0 7 7 10 9 1 Paneler 3 4 4 10 9 8 1 Paneler 4 4 7 10 9 10 1 Paneler 5 5 7 10 10 10 0 Total score 14/50 31/50 47 / 50 46/50 47/50 5/50 Comprehensive evaluation Somewhat effective Effective Very effective Very effective Very effective Somewhat effective

B iSi¾uton (c

[0119] From Table 23, the effect of improving pores is effective when the pressure of the pressure treatment is 50 ~; L 90MPa. If the pressure is out of the above range, the improvement effect of pores is slightly reduced. I understood it. From Table 24 and Table 25, it can be seen that the pore improvement effect is effective when the treatment time is 15 minutes or more, and extremely effective when the treatment temperature is 30 50 C. Tsutsu.

[0120] (5) Improvement of skin texture The sensory evaluation of the degree of improvement in skin texture was performed using photographs taken before and after the application of the cosmetic liquid, taken by sensory evaluation of the improvement degree of pores.

 The comparison of skin texture was conducted by five specialist referees. The skin texture was “improved” (+2), “slightly improved” (+1), “no change” (± 0) , “Slightly worsened” (1) and “Deteriorated” (1 2) were evaluated in 5 grades (the score in Katsuko is rated). In addition, for the evaluation of each paneler, the scores of the five panelists were totaled, and the scores obtained by each paneler were added together to comprehensively evaluate the effect of improving skin texture. The overall evaluation criteria are “No effect” when the total score of the five panelists is less than 10% of the full score (50 points), “Slightly effective” when the total score is 10% or more and less than 40%. ”,“ Effective ”when 40% or more and less than 80%, and“ Very effective ”when 80% or more. The results are shown in Tables 26-28.

[Table 26]

Table 26

Evaluation test example 13 (5) (i): Pressurization treatment and evaluation of serum B (formulation example 9): Pressure change> Treatment time: 30 minutes, Treatment temperature: 32 ^D C

 Processing pressure (MPa) Pressure treatment

40 50 90 150 190 200 None Improvement of skin texture>

Paneler 1 0 7 10 10 10 5 2 Paneler 2 1 10 8 10 9 8 1 Paneler 3 3 8 10 7 8 6 1 Paneler 4 3 10 10 6 5 7 1 Paneler 5 5 5 7 10 10 5 0 Total score 12/50 40/50 45/50 43/50 42/50 31 no 50 5/50 Overall evaluation Somewhat effective Very effective Very effective Very effective Very effective Very effective Effective slightly

Table 27

 Evaluation test example 13 (5) (ii): Pressurization treatment and evaluation of essence B (Prescription example 9): Change over time> Treatment pressure: 90 MPa, Treatment temperature: 32¾ Treatment time Pressure treatment

10 minutes 15 minutes 30 minutes 60 minutes 24 hours None Improvement of skin texture>

Paneler 1 0 6 10 10 8 2 Paneler 2 0 6 8 8 10 1 Paneler 3 3 4 10 10 10 1 Paneler 4 5 5 10 8 8 1 Paneler 5 5 6 7 6 7 0 Total score 13/50 27/50 45 / 50 42/50 43/50 5/50 Overall evaluation Somewhat effective Effective Very effective Very effective Extremely effective Somewhat effective

s s s s

τ

 ^ G

[0124] From Table 26, the improvement effect of skin texture is extremely effective when the pressure of the pressure treatment is 50 to 190MPa. I was convinced that the degree was slightly lower. In addition, according to Table 27 and Table 28, the effect of improving skin texture is effective when the treatment time is 15 minutes or more, and the treatment temperature is 30 to 50. It was found to be extremely effective when C.

[0125] (6) Improvement of skin transparency Five women in their 30s to 60s were panelists, and the face of each paneler was washed with a commercially available face-washing foam, and the moisture was wiped off with a towel. Next, the L value was measured with a spectrocolorimeter (CD100, manufactured by Yokogawa M & C Co., Ltd.) at the portion of the right face of each panel where the spots were not worrisome. After the measurement, the cosmetic solution BO. 2 g of Prescription Example 9 that had been subjected to the predetermined pressure treatment was evenly applied to the right face. 6 hours after application of serum, L value at the same location as before application is measured with the above spectrocolorimeter, and L value before application is subtracted from L value after 6 hours from application. Asked.

 [0126] As a result, by using the cosmetic liquid B of Prescription Example 9, even when no pressure treatment was performed, the conditions of the pressure treatment were any of those shown in (i) to (iii) of Evaluation Test Example 13 Even if the conditions are the same, the force with a certain degree of improvement in the degree of improvement in skin transparency, the treatment pressure force S50 ~ 190MPa, the treatment time is 15 minutes or more, the treatment temperature When the temperature was 30 ° C or higher and 50 ° C or lower, the degree of improvement in skin transparency was extremely good.

 [0127] Formulation Example 10 (Preparation of whitening emulsion)

[0128] [Table 29]

Table 29

 Example 10: Whitening emulsion>

 Ingredients Amount

 Component name

 Number (% by weight)

 1 Beeswah 0.5

 2 Petrolatum 2.0

 3 Skull Run 8.0 8.0

 4 Sorbitan Sesquioleate 0.8

 5 Polyoxyethylene oleyl ether (20E.O.) 1.2

 6 d— 5 Tocopherol 1.0

 7 Arbutin 2.0

 8 1 3—Butylene glycol 7.0

 9 Carboxyvinyl polymer 0.2

 10 Potassium hydroxide 0.1

 11 Purified water balance

 12 Preservatives, antioxidants 璽

 13 Ethanol 7.0

 Mouth p 屮 100.0

[0129] In the above-mentioned formulation, component numbers;! To 5 are mixed and dissolved by heating, 80. Adjusted to C. On the other hand, the component numbers 6 to 12 are mixed and dissolved by heating, 80. While adjusting to C, add the mixture of component numbers;! ~ 5 to this and emulsify, then 50 with stirring. Cooled to C. Then mix ingredient number 13 while adjusting the mixture to 50 ° C. A whitening emulsion was prepared by stirring and cooling to C.

[0130] Evaluation Test Example 14 (Pressure treatment and evaluation of emulsion for whitening) (Pressure treatment)

 A sample was obtained in the same manner as in the pressure treatment of Evaluation Test Example 1 except that 2 g of the whitening emulsion of Formulation Example 10 was used instead of 2 g of the emulsion of Formulation Example 1.

 Thus, each sample consisting of the whitening emulsion of Prescription Example 10 was subjected to pressure treatment under the following conditions (i) to (iii).

 (i) The treatment time was fixed at 30 minutes, the treatment temperature was fixed at 32 ° C, and the treatment pressure was set at 40, 50, 90, 150, 190 and 200 MPa.

 (ii) The treatment pressure was fixed at 90 MPa, the treatment temperature was fixed at 32 ° C, and the treatment time was set to 10 minutes, 15 minutes, 30 minutes, 60 minutes and 24 hours.

 (iii) The processing pressure is fixed at 90 MPa, the processing time is fixed at 30 minutes, and the processing temperatures are 9, 10, 20, 30, 40, 45, 50 and 55, respectively. Each temperature of C was set.

 [0131] Next, a sensory evaluation of the whitening effect was performed on the samples subjected to the pressure treatment under the conditions (i) to (iii).

 (Evaluation of whitening effect)

 20 females in their 20s to 50s were panelists, and each panelist used the whitening emulsion for one week, and then the whitening effect before the start of use and after one week had passed (improved skin color) The degree of whitening was observed, and the sensory evaluation was performed.

 [0132] The evaluation was as follows: “Improved very much” (+ 3), “Improved” (+ 2), “Slightly improved” (+1), “No change” (± 0) , “Slightly worsened” (1), “Deteriorated” (1 2), and “Very worse” (1 3). In addition, 20 panelists' self-scoring scores were added together to comprehensively evaluate the skin color improvement effect. The overall evaluation criteria are “No effect” when the total score is less than 10% of the full score (60 points), “Slightly effective” when the total score is 10% or more and less than 40%, 40% or more When it was less than 80%, “effective”, and when it was 80% or more, “very effective”. The results are shown in Tables 30-32.

[0133] [Table 30]

Table 30

 <Evaluation Test Example 14 (i): Pressurization and Evaluation of Whitening Emulsion (Formulation Example 10): Pressure Change> Processing Time: 30 min. Processing Temperature: 32¾

 Processing pressure (MPa) Pressure treatment

40 50 90 50 90 200 None

<Improvement of skin tone>

 Very improved (+3) 0 2 13 13 13 0 0 Improved (+2) 0 6 5 6 5 5 0 Slightly improved (+1) 7 8 2 1 2 6 6 No change (± 0) 8 4 0 0 0 9 8 Slightly worsened (-1) 5 0 0 0 0 0 6 Worse (-2) 0 0 0 0 0 0 0 Very worse (-3) 0 0 0 0 0 0 0 Total score 2 / 60 26/60 51/60 52/60 51/60 16/60 0/60

 Very very very slightly

Overall evaluation No effect Effective No effect Effective Active Effective Effective

Table 31

 <Evaluation Test Example 14 (ii): Pressurization and Evaluation of Whitening Emulsion (Formulation Example 10): Change over Time> Processing Pressure: 90 MPa, Processing Temperature: 32 C

 Processing time Pressure treatment

10 minutes 15 minutes 30 minutes 60 minutes 2 hours None

<Improvement of skin tone>

Very improved (+3) 0 1 13 15 15 0 Improved (+2) 0 6 5 5 5 0 Slightly improved (+1) 6 10 2 0 0 6 No change (Sat.) 8 3 0 0 0 8 Slightly worsened (-1) 6 0 0 0 0 6 Deteriorated (_2) 0 0 0 0 0 0 Very worse (-3) 0 0 0 0 0 0 Total score 0/60 25/60 51/60 55/60 55/60 0/60 Total S parity No effect No effect Very effective Very effective Very effective No effect

[0136] According to Table 30, the whitening effect (degree of improvement in skin color) is effective when the pressure of the pressure treatment is 50 MPa or more, and when it exceeds 190 MPa, the degree of whitening may be slightly reduced. Wow, ivy. Also, the whitening effect (improvement level of skin color) is effective when the processing time is 15 minutes or more and effective when the processing temperature is 10 50 C from Table 31 and Table 32. I was strong.

[0137] Formulation Example 11 (Preparation of serum C) [0138] [Table 33]

Table 33

 Prescription Example 11: Essence C>

 Ingredients Amount

 Component name

 (Wt%)

 1 Salicylic acid 0.2

 2 Skull Run 8.0

 3 Petrolatum 2.0

 4 low 0.5

 5 Sorbitan Sesquioleate 0.8

 6 Polyoxyethylene glycol ether (20E.O.) 1.2

 7 Carboxyvinyl polymer 0.2

 8 Potassium hydroxide 0.1

 9 Ethanol 7.0

 10 Preservatives and antioxidants

 11 Purified water balance

 100.0

[0139] In the above compounding recipe, component numbers;! To 6 were mixed, melted by heating, and adjusted to 80C. On the other hand, component numbers 7 8 10 and 11 are mixed, melted by heating, adjusted to 80 ° C., and added to emulsify the mixture of component numbers:! To 6 and then stirred to 50 ° Cooled to C. Then, while adjusting the mixture to 50 ^e C, Component No. 9 was mixed, and the mixture was stirred and cooled to 40 ° C. to prepare cosmetic liquid C. [0140] Evaluation Test Example 15 (Coating and evaluation of serum C)

 (Pressure treatment)

 A sample was obtained in the same manner as the pressure treatment of Evaluation Test Example 1 except that the cosmetic liquid C2g of Formulation Example 11 was used instead of the emulsion 2g of Formulation Example 1.

 In this way, each sample comprising the cosmetic liquid C of Prescription Example 11 was subjected to pressure treatment under the following conditions (i) to (iii).

 (i) The treatment time was fixed at 30 minutes, the treatment temperature was fixed at 32 ° C, and the treatment pressure was set at 40, 50, 90, 150, 190 and 200 MPa.

 (ii) The treatment pressure was fixed at 90 MPa, the treatment temperature was fixed at 32 ° C, and the treatment time was set to 10 minutes, 15 minutes, 30 minutes, 60 minutes and 24 hours.

 (iii) The processing pressure is fixed at 90 MPa, the processing time is fixed at 30 minutes, and the processing temperatures are 9, 10, 20, 30, 40, 45, 50 and 55, respectively. Each temperature of C was set.

 [0141] Next, the samples subjected to pressure treatment under the above conditions (i) to (iii) were subjected to a sensory evaluation of the degree of improvement in acne!

 (Evaluation of degree of improvement of acne)

 A panel of 15 women in their 20s and 30s who have blowouts on their faces. Each panelist uses serum C for one week, and then before using it for one week. The state of the face after the lapse was observed, and sensory evaluation of the degree of improvement of acne was performed. For serum C, apply pressure treatment to the left face, apply pressure treatment to the right face, and observe and contrast the left and right faces during sensory evaluation. .

[0142] Evaluation criteria for improvement of acne are “significantly effective” when the acne disappears (+3), and “effective” when the acne is significantly reduced compared to the beginning (+3). + 2), “Slightly effective” (+1) when wrinkles were reduced compared to the start, and “No change” (± 0) when there was no change compared to the start. In addition, when the amount of millet is slightly increased compared to the beginning, it is “slightly worse” (1), and when the amount of double is increased compared to the beginning, it is “deteriorated” (1). In the case where the number of acne was significantly increased, it was rated as “significantly worse” (1), and was rated on a 7-point scale (the score in Katsuko is rated). In addition, the scores of 15 panelists who were self-scored were totaled, and the improvement effect of acne was comprehensively evaluated. The overall evaluation standard is that the total score is less than 10% of the full score (45 points). `` No effect '' when full, `` Slightly effective '' when 10% or more and less than 40%, 40

“Effective” when the percentage is above 80% and below 80%, and “very effective” when the percentage is above 80%. The results are shown in Table 3436.

[0143] [Table 34]

WISΦΪI «s ΕΪS¾ 1S οεΜi« isΏaa A_s ._..- ..

 0 £

[0144] [Table 35]

Table 35

 <Evaluation test example 15 (ίί) .. Pressurization treatment and evaluation of serum C (Prescription example 11): change over time> Treatment pressure: 90 MPa, treatment temperature: 32 ° C

 Processing time Pressure treatment

10 minutes 15 minutes 30 minutes 60 minutes 24 hours None

<Degree of improvement of millet>

 Remarkably valid (+3) 0 2 15 15 15 0 Valid (+2) 0 10 0 0 0 0 Slightly valid (+1) 7 3 0 0 0 3 No change (± 0) 8 0 0 0 0 12 Slightly worse (-1) 0 0 0 0 0 0 Deterioration (-2) 0 0 0 0 0 0 Significant deterioration (-3) 0 0 0 0 0 0 Total score 7/45 29/45 45/45 45/45 45 / 45 3/45

 Slightly very extremely

Overall evaluation Effective Not effective Effective Effective Active Effective

Jie Ji

1 difficulty ¾ ;? <~ si>

 鄭 n-ri

I

[0146] From Table 34, the improvement effect of acne is effective when the pressure of the pressure treatment is 50 to 190MPa, and the degree of improvement effect of acne is slightly lower if the above range is exceeded. To become a power, I got. Also, according to Table 35 and Table 36, the improvement effect of acne is effective when the processing time is 15 minutes or more, and is extremely effective when the processing temperature is 20 to 50 ° C. I understood.

[0147] Formulation Example 12 (Preparation of anti-inflammatory emulsion) [0148] [Table 37]

Table 37

 <Prescription Example 12: Anti-inflammatory emulsion>

 Ingredients Amount

 Component name

 Number (% by weight)

 1 Beeswah 0.5

 2 Petrolatum 2.0

 3 Skull Run 8.0

 4 Sorbitan sesquioleate 0.8

 5 Polyoxyethylene olefin ether (20E.O.) 1.2

 6 d— 5— 卜 Kofue Mouth 1.0

 7 Stearyl glycyrrhetinate 0.5

 8 1, 3 Butylene glycol 7.0

 9 Carboxyvinyl polymer 0.2

 10 Potassium hydroxide 0.1

 11 Purified water balance

 12 Preservatives, antioxidants Suitable summer

 13 Ethanol 7.0

 Mouth 100.0

[0149] In the above formulation, component numbers 1 to 5 were mixed, dissolved by heating, and adjusted to 80 ° C. On the other hand, component Nos. 6 to 12 were mixed, dissolved by heating, adjusted to 80 ° C, emulsified by adding the mixture of component Nos. 1 to 5, and then stirred up to 50 ° C. Cooled down. Thereafter, while adjusting the mixture to 50 ° C, Component No. 13 was mixed, stirred to 40 ° C and cooled to obtain an anti-inflammatory emulsion. [0150] Evaluation Test Example 16 (Pressure treatment and evaluation of anti-inflammatory emulsion)

 (Pressure treatment)

 A sample was obtained in the same manner as the pressure treatment of Evaluation Test Example 1 except that 2 g of the anti-inflammatory emulsion of Formulation Example 12 was used instead of 2 g of the emulsion of Formulation Example 1.

 Thus, each sample comprising the anti-inflammatory emulsion of Prescription Example 12 was subjected to pressure treatment under the following conditions (i) to (iii).

 (i) The treatment time was fixed at 30 minutes, the treatment temperature was fixed at 32 ° C, and the treatment pressure was set at 40, 50, 90, 150, 190 and 200 MPa.

 (ii) The treatment pressure was fixed at 90 MPa, the treatment temperature was fixed at 32 ° C, and the treatment time was set to 10 minutes, 15 minutes, 30 minutes, 60 minutes and 24 hours.

 (iii) The processing pressure is fixed at 90 MPa, the processing time is fixed at 30 minutes, and the processing temperatures are 9, 10, 20, 30, 40, 45, 50 and 55, respectively. Each temperature of C was set.

 [0151] Next, a sensory evaluation of the anti-inflammatory effect was performed on the samples that were pressure-treated under the conditions (i) to (iii).

 (Evaluation of anti-inflammatory effect)

 Panels consisted of 10 men with sensitive skin shaving with a razor every day, and each paneler used anti-inflammatory latex after shaving with a razor, and then 30 minutes after shaving. The state of the face (redness and itchiness) was observed, and sensory evaluation of the anti-inflammatory effect (improvement of the inflammatory state) was performed. The anti-inflammatory emulsion is applied to the left face with the pressure treatment applied, and applied to the right face with the non-pressure treatment applied, and the left and right faces are observed during sensory evaluation. Contrast.

[0152] The evaluation was based on anti-inflammatory effects: “significantly effective” (+3), “effective” (+2), “somewhat effective” (+1), “no change” (± 0), In addition, the evaluation was made on a five-point scale (rating in Katsuko): “Deterioration” (—1). In addition, the scores from the self-scoring of 10 panelists were totaled to comprehensively evaluate the effect of improving the inflammatory condition. The overall evaluation criteria are “No effect” when the total score is less than 10% of the full score (60 points), “Slightly effective” when the total score is 10% or more and less than 40%, 40 “Effective” when the percentage is above 80% and below 80%, and “very effective” when the percentage is above 80%.

 40 50 90 150 190 200 None

<Improvement of inflammation>

Remarkably effective (+3) 0 2 7 6 5 0 0 Effective (+2) 0 5 3 2 3 0 0 Slightly effective (+1) 2 3 0 2 2 3 0 No change (± 0) 6 0 0 0 0 6 9 Deterioration (-1) 2 0 0 0 0 1 1 Total score 0/30 19/30 27/30 24/30 23/30 2/30 -1/30 Overall evaluation No effect No effect 'L " _ Effective No effect No effect

Table 39

 <Evaluation Test Example 16 (ii): Pressurization and evaluation of anti-inflammatory emulsion [Formulation Example 12]: Change over time> Processing pressure: 90 MPa, Processing temperature: 32 ° C Processing time Pressurizing

10 minutes 15 minutes 30 minutes 60 minutes 24 hours None

<Improvement of inflammation>

Remarkably effective (+3) 0 0 7 6 7 0 Effective (+2) 0 1 3 4 3 0 Slightly effective (+1) 0 1 0 0 0 0 No change (± 0) 8 8 0 0 0 9 Deterioration (-1) 2 0 0 0 0 1 Total score -2/30 3/30 27/30 26/30 27/30 -1/30 Overall evaluation No effect Somewhat effective Very effective Very effective Very effective No effect

[0156] From Table 38, it was found that the anti-inflammatory effect was effective when the pressure of the pressure treatment was 50 to 190 MPa. In addition, Table 39 and Table 40 show that it is effective when the treatment time is 15 minutes or more, and extremely effective when the treatment temperature is 20 to 50 ° C.

 Formulation Example 13 (Preparation of Cream B)

[0157] [Table 41] Actual component name comparison example comparison proportional proportion ratio 1 generation number 321 minutes

[0158] In the above formulation, the creams of Example 1 and Comparative Example 13 were formulated. Specifically, first, component numbers 1 to 12 were mixed, dissolved by heating, and adjusted to 70 ° C. Separately, component number 13 was mixed with component number 13, dissolved by heating, and adjusted to 70 ° C. Thereafter, the mixture of component numbers;! To 12 and the mixture of component numbers 13 to 15 were mixed, emulsified with a homomixer, and then cooled to prepare a cream.

In Table 1, “POB” is an abbreviation for polyoxybutylene, and rpQEj is polyoxybutene. It is an abbreviation for tylene, and “POP” is an abbreviation for polyoxypropylene. In addition, the numerical value written in “katsuko” after “POB”, “PO E” or “POP” indicates the number of moles (the same applies hereinafter). In addition, wilyl ether (glycerin 1 mol part, POB3 monole part, POE8 monole part, POP 5 mol part, manufactured by NOF Corporation), and white jellyfish polysaccharide is Tremoist TP (manufactured by Nippon Seika Co., Ltd.) ( The same applies below).

[0160] Evaluation Test Example 17 (Evaluation of cream)

 (Pressure treatment)

 2g each of cream B from Formulation Example 13 is placed in a small-capacity heat-sealed bag (Uniback A-4, manufactured by Nihonsha Co., Ltd.), degassed, and then heat-sealed (Desktop vacuum sealer for business use SQ-202, Sharp Sealing was performed using The sealed small-capacity heat seal bag is put together into the large-capacity heat paper bag (Uniback F—4, manufactured by Production Japan Co., Ltd.) for the number of times of measurement in each evaluation test example to be described later. The same as above) was used to seal a large-capacity heat seal bag, which was used as a sample.

[0161] Thus, each sample consisting of Cream B of Formulation Example 13 was subjected to a hydrostatic press (water tank capacity:

 8L, design pressure: max. 100MPa, design temperature: max. 75 ° C, body material: SUS630), set the cream temperature to 32 ° C, pressurize for 30 minutes at 90MPa pressure I managed.

 Next, for each sample after pressure treatment, the following sensory evaluations (1) and (2) were performed.

Yes

 [0162] (1) Improvement level of wrinkles

 After 15 minutes from the end of the pressure treatment, 2 g of the cream BO. In this way, the state of eye contact before application and after 3 hours from application was observed with the naked eye and photographs to evaluate the degree of wrinkles. Figure 4 shows photographs taken before and 3 hours after application. In addition, since it is necessary to compare the Example and the Comparative Example with the same person, each measurement was performed at intervals of 30 days.

[0163] From FIG. 4, it was found that when the cream B of Example 1 was applied, the wrinkle improvement was more remarkable than when the cream B of Comparative Examples 1 to 3 was applied. (2) Moisturizing effect

 The cream BO.02g of the prescription example 13 was uniformly applied to the inside part of the upper arm of a healthy male at 2 cm × 2 cm square. SKICON-200 type skin surface moisture measuring device after 10 minutes, 20 minutes, 30 minutes, 1 hour, 4 hours and 24 hours from application

 <3 瞓 ^ 2

The amount of water (unit: 11 S (micro Siemens)) was measured. The results are shown in Table 42. The moisture content is measured five times for each measurement item and shown as the average value.

[Table 42]

Table 42

 10 minutes later 20 minutes later 30 minutes later 1 hour later 4 hours later 24 hours later

elapsed time

[0165] From Table 42, it was found that the moisturizing effect when the cream B of Example 1 was applied was significantly better than the moisturizing effect when the cream B of Comparative Example 13 was applied. It was. Formulation Example 14 (Preparation of serum D)

[0166] [Table 43]

[0167] Cosmetic liquid D of Example 2 and Comparative Example 45 was prepared using the above-mentioned formulation. Specifically, first, component number 36 was mixed and heated to 80 ° C. to dissolve the mixture. on the other hand Ingredient Nos. 1, 2 and 7-; 12 were mixed and heated to 80 ° C. to dissolve the mixture. Next, the mixture of component numbers 3 to 6 was mixed with the mixture of component numbers 1, 2 and 7 to 12 and stirred at high speed for 1 minute with a homomixer, and then air-cooled to 60 ° C with slow stirring. . Thereafter, Component No. 13 was mixed, and water-cooled to 35 ° C with slow stirring to prepare Beauty Liquid D.

 [0168] Evaluation Test Example 18 (Evaluation of serum D)

 A sample was obtained in the same manner as the pressure treatment of Evaluation Test Example 17 except that the cosmetic liquid D2g of Formulation Example 14 was used instead of Cream B2g of Formulation Example 13.

 In this way, each sample consisting of the cosmetic liquid D of Prescription Example 14 was set so that the temperature of the cosmetic liquid D was 32 ° C., and pressurized at a pressure of 90 MPa for 30 minutes.

[0169] Next, for each sample after the pressure treatment, the following sensory evaluations (1) to (3) were performed.

 (1) Improvement of elasticity and lift-up effect

 Panelists were five healthy women in their 40s and 60s. In each panel, wash the face with a commercially available face wash foam, wipe off the moisture with a towel, and then apply DOG 2g of Prescription Example 14 uniformly on one half face, and the other half face The sample was left uncoated until the next day. The next day, the condition of the skin was observed, and the sensory evaluation was performed for the degree of improvement of the elasticity and the lift-up effect. In the sensory evaluation, the skin condition before and after the test was compared and scored based on the following evaluation criteria. The results are shown in Table 44.

 5: Improved 4: Slightly improved 3: No change 2: Slightly deteriorated 1: Deteriorated

[0170] [Table 44]

* Vs¾ls- </ sw.

 s s

 χ s ^ τ s

 s

 T s ^

(2) Improvement of pores, improvement of texture

Panelists were five healthy women in their 40s and 60s. In each panel, wash the face with a commercially available face wash foam, wipe off the moisture with a towel, and then apply DOG 2g of Prescription Example 14 uniformly on one half face, and the other half face The sample was left uncoated until the next day. And the state of the skin was evaluated the next day. In the evaluation, a microscope (Char m Lite Stand III: Moritex Co., Ltd.) was used to photograph pores and textures, and beauty. The state before and after application | coating of a liquid was compared. In the comparison method, five specialist referees evaluated the improvement in pores and improvement in texture based on the following evaluation criteria, and the average value was used as the evaluation result. The results are shown in Table 4550.

[0172] Further, photographs before and after application of cosmetic liquid D are shown in Fig. 5 (evaluation of pores) and Fig. 6 (evaluation of texture).

 2: Improved 1: Slightly improved w Improved 0: Unchanged 1 1: Slightly degraded 1 2: Deteriorated

 «* SiiΐIS st ()! F α Vs

[0173] [Table 45]

 e W 矚 * ftfffr

* ¾f s o Ό

[] 0175 Table 46

 <Evaluation Test Example 18 (2): Evaluation of Essence D (Prescription Example 14)>

 Improvement of ridges> Referee

 Total score Average value Standard deviation

 [Comparative Example 4] 1 2 3 4 5

 / Neller 1 1 1 1 1 1 5 1.0 0

 2 0 1 1 0 1 3 0.6 0.547723

 3 1 1 1 1 1 5 1.0 0

 4 1 1 1 1 1 5 1.0 0

 | l

 5 1 0 0 0 0 1 0.2 0.447214

 4 4 4 3 4 Total: 19

 Average value I 0.8 0.8 0.8 0.6 0.8 Overall average value: 0.76

 Standard deviation 0.45 0.45 0.45 0.55 0.45 Overall standard deviation: 0.44

] 0 ¾71] 464

[] 0 [¾176] 48

 Table 47

 <Evaluation Test Example 18 (2): Evaluation of Essence D (Prescription Example 14)>

 Improvement of the pores> Refri

 Total score Average value Standard deviation

[Comparative Example 5] 1 2 3 4 5

 Paneler 1 1 1 1 1 1 5 1.0 0

2 1 1 0 1 0 3 0.6 0.547723

3 1 1 1 1 1 5 1.0 0

4 1 1 1 1 1 5 1.0 0

5 0 1 1 1 1 4 0.8 0.447214 Total score 4 5 4 5 4 Total: 22

Average 0.8 1.0 0.8 1.0 0.8 Overall average: 0.88 Standard deviation 0.45 0.00 0.45 0.00 0.45 Overall standard deviation: 0.33

[] (^ S4

 Table 48

 <Evaluation Test Example 18 (2): Essence D (Evaluation of Prescription Example 14>)

 Improvement level> Referee

 ― Total score Average value Standard deviation

[Example 2] 1 2 3 4 5

 Paneler 1 2 1 2 2 2 9 1.8 0.447214

2 2 2 1 1 2 8 1.6 0.547723

3 2 2 2 2 2 10 2.0 0

4 1 2 1 1 1 6 1.2 0.447214

5 1 2 1 1 1 6 1.2 0.447214 Total score 8 9 7 7 8 Total: 39

Average 1.6 1.8 1. 1.4 1.6 Overall average: 1.56 Standard deviation 0.55 0.45 0.55 0.55 0.55 Overall standard deviation: 0.51

[] [Temporary]

 Table 49

 <Evaluation Test Example 18 (2): Evaluation of Essence D (Prescription Example 14)>

 Improvement level> Referee

 Total score Average value Standard deviation

[Comparative Example 4] 1 2 3 4 5

 Paneler 1 1 1 1 1 1 5 1.0 0

2 0 0 1 0 1 2 0.4 0.547723

3 1 1 0 1 1 4 0.8 0.447214

4 1 1 1 1 1 5 1.0 0

5 0 0 1 0 0 1 0.2 0.447214 Total score 3 3 4 3 4 Total: 17

Average 0.6 0.6 0.8 0.6 0.8 Overall average: 0.68 Standard deviation 0.55 0.55 0.45 0.55 0.45 Overall standard deviation: 0.48

¾〇9

[0Π9] Further, as can be seen from the portion surrounded by circles in FIG. 5, in Comparative Examples ⁴ and 5, it was observed that the pores were opened, but in Example 2, the pores were centered. It was observed that the textured line extended and the pores became smaller.

Further, in FIG. 6, in Comparative Examples 4 and 5, the texture line is not observed so much, but in Example ² , it was observed that the texture extends radially around the pores.

[0180] (3) Improvement of transparency Panelists were five healthy women in their 40s and 60s. In each panel, after washing the face with a commercially available face wash foam and wiping off moisture with a towel, apply the beauty liquid DO. 2g of Prescription Example 14 evenly on the face, immediately after application, 3 hours after application, At each time point 6 hours after application, the transparency (L value) was measured. In the measurement of transparency, a spectrocolorimeter CD100 (manufactured by Yokogawa M & C Co., Ltd.) was used to measure the L value of the portion of each panel where the spots were not worrisome. The measured value was determined as the value obtained by measuring the L value at the same location as before coating with the above spectrocolorimeter and subtracting the L value before coating from the L value after each time elapsed from coating.

 [0181] Also, based on the above results, the evaluation of improvement in transparency was evaluated in light of the following criteria I to IV. The results are shown in Table 51.

 I: L value difference 1.5 or more

 II: Difference in L value 1.0 or more and less than 1.5 Improvement is seen

 111 丄 Difference between 0.5 and 1.0 Less than 0

 IV: Difference in L value Less than 0.5 No change

[0182] [Table 51]

Table 51

 Evaluation Test Example 18 (3): Evaluation of serum D (Prescription Example 14)>

<Improvement of transparency> Example 2 Comparative example 4 Comparative example 5

[Immediately after]

 L value: Paneler 1 1 0.83 0.18 0.76 Paneler 2 3.43 0.32 0.77 Paneler 3 1 0.22 0.03-0.19 Paneler 4 1 0.31 0.50 1 0.41 Paneler 5 0.68 0.41 1 0.42 Average 0.55 0.288 0.102

[After 3 hours]

 U: Paneler 1 0.47 0.28 0.31 Paneler 2 4.41 0.21 0.64 Paneler 3 1 0.20 0.75 0.00 Paneler 4 1 0.20 0.99 1 0.54 Paneler 5 0.52 0.72 0.93 Average 1.00 0.59 0.268

[After 6 hours]

 Threshold: Paneler 1 1.15 071 1 0.30 Paneler 2 4.16 1.88 0.71 Paneler 3 0.42 ― 0.02 0.70 Paneler 4 0.33 1 0.50 0.05 Paneler 5 1.60 1 0.77 1 0.78 Average 1.532 0.26 0.076

[Judgment]

 Immediately 111 IV IV

After 3 hours II III IV

After 6 hours I IV IV

[0183] Formulation Example 15 (Preparation of Facial Wash Form B)

[0184] [Table 52] Table 52

 <Prescription Example 15: Facial cleansing foam B> Unit: Weight "½"

 Ingredient number Component name Blending amount

 1 Stearic acid 12.00

 2 Myristic acid 14.00

 3 Lauric acid 5.00

 4 Skull 1.00

 5 Sorbitol 70 wt% aqueous solution 15.00

 6 Glycerin 10.00

 7 1, 3-Butylene glycol 10.00

 8 POE (20) Glyce Mouth Monostearate 1.00

 POB (3) POE (8) POP (5) Glyceryl ether

 9 0.10

 (`` Wilbright S-753J)

 10 Purified water 26.69

 11 Potassium hydroxide 5.00

 12 EDTA 0.10

 13 Fragrance 0.10

 14 White Jellyfish Polysaccharide 0.01

[0185] A face-wash foam wrinkle was prepared in the above-mentioned formulation. Specifically, first, component numbers 1 to 9 are mixed and dissolved by heating. Adjusted to C. Separately, component number 11 was dissolved in component number 10, and the mixture of component numbers 1 to 9 was added to the mixture while stirring to neutralize it. After completion of the neutralization reaction, the face washing foam B was prepared by further adding component numbers 12 to 14 and cooling with stirring.

[0186] Formulation Example 16 (Preparation of Hair Cream B) 53]

Table 53

<Formulation Example 16: Hair cream B> unit: weight ^_0/0

 Ingredient number Component name Blending amount

 1 Liquid paraffin 5.00

 2 Petrolatum 10.00

 3 Sara honey bees 2.00

 4 Olive oil 5.00

 5 Tokovol acetate 0.20

 6 Noraben 0.20

 7 POE (25) Cetyl alcohol ether 3.00

 8 Glycerol monostearate2.00

 POB (3) POE (8) POP (5) Glyceryl ether

 9 20.00

 (`` Wilbright S-753J)

 10 Purified water 45.50

 11 White jellyfish polypod 1.00

 12 Carboxyvinyl polymer 0.10

 13 Glycerin 5.00

 14 Potassium hydroxide 0.70

 15 Fragrance 0.30

 . f + 100.00

Hair cream B was prepared in the above formulation. Specifically, the ingredients Nos. 1 to 9 are mixed and dissolved by heating. Adjusted to C. Separately, add component numbers 11 to 13 to component number 10 and dissolve by heating. Adjusted to C. Then, the mixture of component numbers 1 to 13 was added to the mixture of component numbers 10 to 13 and emulsified, and the emulsified particles were unified with a homomixer. After that, add component number 14 dissolved in component number 10 to this, Cooled with uniform stirring, and then added ingredient number 15 to prepare hair cream B o

 [0189] Formulation Example 17 (Preparation of hair restorer B)

[0190] [Table 54]

Table 54

 Formulation Example 17: Hair restorer B> Unit:% by weight

 Ingredient number Component name Blending amount

 1 Ethanol 60.00

 2 Glycerin 3.00

 3 Assembly extract 1.00

4 Vitamin B ₆ 0.50

 5 Tocopherol acetate 0.20

 6 POE (20) sorbitan monolaurate 1.00

 7 Fragrance 0.30

 POB (3) POE (8) POP (5) Glyceryl ether

 8 10.00

 (Γ Wil Bright S-753J)

 9 White jellyfish polysaccharide 0.10

 10 Purified water 23.90

 t + 00.00

Hair restorer B was prepared in the above formulation. Specifically, component number 1 8 was mixed and dissolved by heating, and then dissolved in component number 10 and component number 10 Ingredient No. 9 was added and dissolved uniformly to prepare hair restorer B

 Formulation Example 18 (Preparation of serum E)

[Table 55]

 ¾ 9 s¾ 瓣 ¾

In the above formulation, Example 3 and Comparative Examples 6 to 12 cosmetic liquid E was prepared. Specifically, first, components No .:! To 16 were dissolved by heating and kept at 80C. Add the ingredient No. 18 25 to the ingredient No. 17 and dissolve it by heating. ~; After the mixture of 16 was added and emulsified, the emulsified particles were made uniform while stirring with a homomixer. Next, the emulsion was cooled to 50 ° C., the component No. 26 was added, and the mixture was stirred and cooled to 40 ° C., thereby preparing cosmetic liquid E.

[0194] Evaluation Test Example 19 (Evaluation of serum E)

 A sample was obtained in the same manner as the pressure treatment of Evaluation Test Example 17 except that the cosmetic liquid E2g of Formulation Example 18 was used instead of Cream B2g of Formulation Example 13. It should be noted that cosmetic liquid E of Example 3 in Formulation Example 18 has the same composition as Cosmetic Liquid B shown as Formulation Example 9.

 In this way, each sample consisting of the cosmetic liquid E of Formulation Example 18 was set so that the temperature of the cosmetic liquid E was 32 ° C., and was pressurized for 30 minutes at a pressure of 90 MPa.

[0195] Next, the following sensory evaluations (1) to (6) were performed on each sample after the pressure treatment.

 (1) Degree of improvement of the wrinkle 'Resistance of elasticity' Lift-up effect

 Panelists were five healthy women in their 40s and 50s. In each panel, the face was washed with a commercially available face-washing foam, and the moisture was wiped off with a towel. Then, the cosmetic liquid E0.2 of prescription example 18 was applied to either the left or right face, and nothing was applied to the other face and left until the next day. The next day, each paneler's facial skin condition was observed, and sensory evaluations were made regarding the improvement of wrinkles, the improvement of the skin, the improvement of lift and the lift-up effect. In the sensory evaluation, the skin condition before and after the test was compared and scored based on the following evaluation criteria.

 5: Improved 4: Slightly improved 3: No change 2: Slightly deteriorated 1: Deteriorated

 In addition, the test was carried out on both the above samples that had been subjected to pressure treatment (hydrostatic pressure press) (after 15 minutes from the end of the caloric pressure treatment) and those that had not been subjected to pressure treatment. . Table 56 shows the results of the improvement of the seeds, Table 57 shows the results of the improvement of (2) and (2), and Table 58 shows the results of the lift-up effect.

[0196] [Table 56] 3 Table 56

 []

 <Evaluation Test Example 19 (1): Evaluation of Essence E (Prescription Example 18)>

 Example 3 Comparative Example 6 Comparative Example 7 Comparative Example 8 Comparative Example 9 Comparative Example 10 Comparative Example 1 1 Comparative Example 12

<Degree of improvement of shii>

 (With pressure treatment)

 Paneler 1 5 4 5 4 4 4 4 4 Paneler 2 5 4 4 4 4 3 3 3 Paneler 3 5 4 4 4 4 3 4 3 Paneler 4 4 4 4 4 4 3 3 3 Panel 1 5 5 4 4 4 3 3 3 3 Total score 24/25 20/25 21/25 20/25 19/25 16/25 17/25 16/25

(No pressure treatment)

Paneler 1 5 4 4 4 4 3 3 3 Paneler 2 4 4 4 3 3 2 2 2 Paneler 3 5 4 4 4 3 3 2 2 Paneler 4 4 3 3 3 3 2 2 2 Paneler 5 4 4 3 3 2 2 3 2 Total score 22/25 19/25 18/25 17/25 15/25 12/25 12/25 11/25

Table 57

 <Evaluation Test Example 19 (1): Evaluation of Essence E (Prescription Example 18)>

 Example 3 Comparative Example 6 Comparative Example 7 Comparative Example 8 Comparative Example 9 Comparative Example 10 Comparative Example 1 1 Comparative Example 12

<Degree of improvement>

(With pressure treatment)

 Paneler 1 5 4 5 4 4 4 3 3 Paneler 2 5 4 4 3 4 3 4 3 Paneler 3 5 4 4 4 3 4 4 3 Paneler 4 5 4 4 4 4 3 3 3 Paneler 5 5 4 4 3 4 3 4 4 Total score 25/25 20/25 21/25 18/25 19/25 17/25 18/25 16/25

(No processing)

Paneler 1 5 4 4 4 3 2 3 2 Paneler 2 4 4 4 3 3 2 2 2 Paneler 3 4 4 4 3 3 2 2 2 Paneler 4 5 4 4 4 3 3 3 2 Neller 5 4 3 4 3 3 3 3 2 Total score 22/25 19/25 20/25 17/25 15/25 12/25 13/25 0/25

Shun rnsiΙ¾¾fi lwllkk5iv ΛΘ_¾ 一 _ ..

 Comparison Example Comparison Example Example Comparison Example Example Comparison Comparison Ratio 3 Case Proportional 16 Comparison 0982111

 Effect)

Heat treatment (pressure)

 Panera 1

 Panera 2

 ε /

 Panera 4 ー

 Panera 5 ー

 / 90 93/02 9Z612 / 3ZZ / 91 /

 Mosquito (no pressure)

 Panera 1

 Panera 2

 Panera 3

 Panera 4 ー

 Panera 5 ー

 ^ ^ έ 卜 ZRZ 9SH ..

A

 ψ

From Table 56 58, in the cosmetic liquid of Example 3 containing both the white jellyfish polysaccharide (white jellyfish extract) and wilbright (polyoxy,, 'chille, polyoxyethylene polyoxypropylene glyceryl ether), There were many testers who felt a higher effect regarding the improvement of the elasticity and the lift-up effect. In addition, this tendency became even more prominent by applying pressure treatment to the serum. On the other hand, the comparative essence containing either white jellyfish extract and wilbright has improved wrinkle improvement, firmness improvement and Regarding the toe-up effect, the subject felt a slight effect. However, in the comparative essence that did not contain both white jellyfish extract and wilbright, no improvement was observed in the wrinkles, firmness and lift-up effect.

 [0200] (2) Moisturizing effect

 The serum EO.02g of Prescription Example 18 was uniformly applied to the inside part of the upper arm of a healthy male at 2cm x 2cm square. After application, 10 minutes, 20 minutes, 30 minutes, 1 hour, 4 hours and 24 hours, the skin surface horn layer moisture content measuring device SKICON-200 (made by IBS Co., Ltd.) The water content (unit: a S (micro Siemens)) was measured. The results are shown in Table 59. The moisture content is measured five times for each measurement item and shown as the average value.

[0201] [Table 59]

Table 59

 <Evaluation Test Example 19 (2): Evaluation of Essence E (Prescription Example 18)>

 elapsed time

 [Moisturizing effect] 10 minutes 20 minutes 30 minutes 1 hour 4 hours 24 hours

 (With pressure treatment)

 Example 3 55.4 99.0 110.8 89.4 87.2 83.0

 Comparative Example 6 31.6 33.6 35.8 31.4 29.8 29.4

 Comparative Example Ί 29.8 33.8 36.2 32.2 30.4 31.6

 Comparative Example 8 30.2 31.6 36.8 31.2 32.0 31.2

 Comparative Example 9 29.6 30.6 34.0 27.8 28.2 27.8

 Comparative Example 10 31.2 32.2 35.2 28.6 29.2 29.0

 Comparative Example 11 28.4 30.6 32.6 27.0 29.4 29.0

 Comparative Example 12 29.6 30.8 32.2 28.2 29.2 29.8

 (No pressure treatment)

 Example 3 41.6 84.2 97.6 81.8 82.4 81.2

 Comparative Example 6 29.6 31.4 32.4 28.6 29.2 30.2

 Comparative Example 7 29.8 30.0 30.6 28.2 28.8 29.4

 Comparative Example 8 28.8 29.2 29.8 28.4 28.2 29.4

 Comparative Example 9 28 4 29.2 30.2 28.6 28.2 28.6

 Comparative Example 10 28.8 29.6 30.2 28.2 29.4 29.8

 Comparative Example 11 28.8 29.8 30.4 28.6 29.2 29.8

 Comparative Example 12 27.8 28.4 29.2 28.2 28.8 28.2

[0202] From Table 59 :: The essence of Example 3 containing both extract and wilbright (polyoxybutylene polyskin ethyl ester) was moisturized regardless of whether or not it was pressurized. The effect was high. On the other hand, a white fungus extract, in the serums of Comparative Examples ⁶ to ¹ 2 does not include either one or both of the Will Bright, sufficient moisturizing effect is not obtained.

[0203] (3) Improvement degree of pores' Improvement degree of texture Panelists were five healthy women in their 40s and 60s. In each panel, after washing the face with a commercially available face wash foam and wiping off moisture with a towel, apply the cosmetic liquid E0.2 g of Prescription Example 18 uniformly to the left or right face, and The side face was left uncoated until the next day. And the state of the skin was evaluated the next day. In the evaluation, a microscope (Charm Lite Stand III: Moritex Co., Ltd.) was used to photograph the pores and texture, and the state before and after application of the serum was compared. In the comparison method, the improvement of pores and the improvement of texture were evaluated based on the following evaluation criteria by five expert referees, and the average value was used as the evaluation result. The results are shown in Table 60 and Table 61.

2: Improved 1: Slightly improved 0: No change 1: Slightly deteriorated 2: Deteriorated [Table 60]

Table 60

 [] [0205]

 <Evaluation Test Example 19 (3): Evaluation of Essence E (Prescription Example 18)>

 Example 3 Comparative Example 6 Comparative Example 7 Comparative Example 8 Comparative Example 9 Comparative Example 10 Comparative Example 1 1 Comparative Example 12

<Improvement of pores>

 (With pressure treatment)

 Paneler 1 9 9 8 5 5 5 5 5 Paneler 2 8 7 7 3 3 1 5 5 Paneler 3 10 5 5 5 5 4 3 4 Paneler 4 6 9 6 5 5 5 4 0 Neller 5 10 5 3 1 4 1 0 1 Total score 43/50 35/50 29/50 19/50 22/50 6/50 17/50 15/50

(No pressure treatment)

Paneler 1 8 8 8 6 5 5 5 5 Paneler 2 6 5 6 6 2 1 4 5 Paneler 3 6 5 5 5 5 3 1 2 Paneler 4 5 7 5 1 5 5 4 0 Paneler 5 10 5 3 1 1 2 0- 2 Total score 35/50 30/50 27/50 19/50 18/50 16/50 14/50 10/50

Comparative Example Comparative Example Comparative Example Proportional Proportional Proportional Ratio Ratio 12198310761

 Improvement degree texture>

 There is processing (pressure)

)

 -

 -Panella 5-

 / S / εε / Ma

From Table 60 and Table 61,

The cosmetic liquid of Example 3 containing both (oxyethylene polyoxypropylene glyceryl ether) was highly effective in improving pores and texture regardless of the presence or absence of pressure treatment. On the other hand, in the cosmetic solution of the comparative example containing either white jellyfish extract or wilbright, the subject felt a slight effect for improving pores and texture. However, comparison without both white jellyfish extract and wilbright The cosmetic liquid of the example did not improve pores or texture.

 [0207] (4) Improvement of transparency

 Panelists were five healthy women in their 30s and 60s. In each panel, the face was washed with a commercially available face-washing foam, the moisture was wiped off with a towel, and then 2 g of essence liquid EO. Furthermore, at 6 hours after application, the transparency (L value) of each panel was measured. In the measurement of transparency, a spectrocolorimeter CD100 (manufactured by Yokogawa M & C Co., Ltd.) was used, and the L value of the part where the spots were not noticeable on the starboard of each panel was measured. The measured value was obtained by measuring the L value at the same location as before coating with the above spectrocolorimeter and subtracting the L value before coating from the L value 6 hours after coating.

 [0208] Further, based on the above results, the evaluation for improvement in transparency was judged in light of the judgment criteria I to IV in "(3) Improvement of transparency" in Evaluation Test Example 18. The results are shown in Table 62.

[0209] [Table 62]

I — I

 Ό I

[0210] From Table 62, white jellyfish extract and

 All of the cosmetic liquids of Example 3 containing both the polyoxypropylene glyceryl ether and the polyoxypropylene glyceryl ether were highly effective in improving the transparency, regardless of the presence or absence of the pressure treatment. On the other hand, the essence of Comparative Example 6 12 that did not contain either one or both of the extract of the white jellyfish extract and wilbright did not provide a sufficient improvement effect.

[0211] (5) Improvement of hair thickness As the hair, human hair (Burelux Co., Ltd., 250 g, 30 cm) obtained by bleaching (hereinafter referred to as damaged hair) was fixed on a glass slide. Next, the surface state and thickness of the damaged hair were photographed with an optical microscope (BX60, manufactured by Olympus Corporation) and measured. Next, the cosmetic solution E of Formulation Example 18 that had been subjected to a predetermined pressure treatment was applied to the hair on the slide glass and left for 24 hours. After standing, the surface condition and thickness of the hair on the slide glass were photographed and measured with an optical microscope (BX60) in the same manner as before coating, and compared with the measurement results before applying the serum. Table 63 shows the difference (mm) between the measurement result of the damaged hair diameter (mm) and the measurement result before applying the serum.

[Table 63]

In addition, the photographed image of damaged hair by an optical microscope is as shown in FIGS. 3 (a) to 3 (C). The diameter of the damaged hair is 0.080 mm when the cosmetic liquid (Cosmetic liquid B of prescription example 9 or cosmetic liquid E of prescription example 18) is not applied (Fig. 3 (a)). When a cosmetic liquid that has not been subjected to pressure treatment was applied (Fig. 3 (b)), it was 0.085mm and was subjected to pressure treatment (treatment pressure 90MPa, treatment temperature 32 ° C, treatment time 30 minutes). When the cosmetic liquid was applied (Figure 3 (c)), it was 0.095 mm. [0214] (6) Improvement of hair gloss

 As hair, normal hair (Buelux Co., Ltd., human hair black hair, 20g, 15cm) and bundling damaged hair (bleached from the above normal hair) were used. After the bundle was washed with water, the moisture was gently wiped off. Next, the essence E of Formulation Example 18 that had been subjected to a predetermined pressure treatment was applied to each bundle of hairs and allowed to stand for 24 hours. After standing, the hair bundle was washed again with water, thoroughly wiped off moisture, and dried with a dryer. After drying, sensory evaluation was performed on the degree of gloss of the hair bundle.

 [0215] The evaluation was made by visual judgment of five specialist referees based on the gloss of normal hair to which no serum was applied. Also, as a result of visual judgment, gloss improvement is “very high” (+3), “high” (+2), “slightly high” (+1), “does not change” (± 0), “slightly low” (1), “Small” (1), and “Very few” (1) were rated in 7 levels (in Katsuko's score). In addition, the scores of five referees were summed up to comprehensively evaluate the effect of improving hair gloss. The overall evaluation criteria are “no effect” when the total score is less than 10% of the full score (15 points), “somewhat effective” when the total score is 10% or more and less than 40%, 40% or more When it was less than 80%, it was “effective”, and when it was 80% or more, it was “very effective”. The evaluation results are shown in Table 64 and Table 65.

[0216] [Table 64]

Table 64

 <Evaluation Test Example 19 (6): Evaluation of Essence EC Prescription Example 18)>

 (With pressure treatment)

Improvement of hair gloss> Example 3 Comparative example 6 Comparative example 7 Comparative example 8 Comparative example 9 Comparative example 10 Comparative example 11 Comparative example 12

[Normal hair]

 Very much (+3) 4 0 0 0 0 0 0 0 More (+2) 1 3 2 1 0 0 0 0 Slightly more (+1) 0 2 2 3 3 2 0 0 No change (Sat.) 0 0 1 1 2 3 2 4 Slightly less (-1) 0 0 0 0 0 0 3 1 Less (-2) 0 0 0 0 0 0 0 0 Very few (-3) 0 0 0 0 0 0 0 0 Total score 14/15 8/15 6/15 5/5 3/15 2/15 -3/15 -1/15 Comprehensive evaluation Very effective Effective Effective slightly effective Effective slightly effective Not effective Ineffective

[Damaged hair]

Very high ( ⁺³ ) 5 1 0 0 0 0 0 0 High (+2) 0 3 2 2 0 0 0 0 Slightly high (+1) 0 1 3 2 2 1 1 0 No change (± 0) 0 0 0 1 3 3 2 2 Slightly less (-1) 0 0 0 0 0 1 2 3 Less (-2) 0 0 0 0 0 0 0 0 Very few (-3) 0 0 0 0 0 0 0 0 Total score 15/15 10/15 7/15 6/15 2/15 0/15 -1/15 -3/15 Overall evaluation Extremely effective Effective Effective Effective Effective Somewhat ineffective Ineffective Ineffective

Evaluation Test Example 20 (Evaluation of solubility of white jellyfish polysaccharide)

 (1) Visual observation

0.110 parts by weight of active ingredients of white jellyfish polysaccharide (trade name: Tremoist), Nikkor BC-20TX (Boroxyethylene cetyl ether (20Ε · O.)) 5.00 parts by weight, and scranium 0.15 A total of 100 parts by weight of cosmetic was prepared by blending parts by weight with 94.75 parts by weight of water (this is referred to as Comparative Sample 1). [0219] Nikkor BC—Instead of 20TX (polyoxyethylene cetyl ether (20Ε · Ο.)), Nikkorole PBC34 (polyoxyethylene (5) polyoxypropylene (8) cetinoreate nore) 5.00 parts by weight Except for the above, a cosmetic was prepared in the same manner as Comparative Sample 1 (this was referred to as Comparative Sample 2).

 On the other hand, instead of Nikkor BC-20mm and Nikkor PBC34, Willbride S-7

A cosmetic was prepared in the same manner as Comparative Sample 1 except that 00 parts by weight was added (this is referred to as Sample 1).

 [0220] Visual observation of the above samples revealed that in Comparative Samples 1 and 2, the cosmetics were cloudy and were suspensions. On the other hand, in Sample 1, the cosmetic was not cloudy and showed a good dissolved state. In other words, it was found that the white jellyfish polysaccharide is sufficiently dissolved in the oily medium when it coexists with polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether.

 [0221] (2) Measurement of turbidity

 For sample 1 and comparative samples 1 and 2, the absorbance of the specimen at a wavelength of 650 nm was measured with a spectrophotometer (manufactured by Shimadzu Corporation, UV-2450), and turbidity was measured. In measuring the turbidity, first, an aqueous suspension in which kuto soil (manufactured by Wako Pure Chemical Industries, Ltd.) was dispersed at a concentration of 100 mg / L was designated as turbidity 100. Further, the water suspension was diluted and the absorbance was measured, and a calibration curve showing the relationship between absorbance and turbidity was prepared. The turbidity of the beauty solution of each sample is a value calculated based on the calibration curve. The turbidity indicates that the closer the value is to 0, the higher the transparency.

 [0222] As a result of the above measurement, the turbidity of sample 1 was 35, whereas the turbidity of comparative sample 1 was 185, and the turbidity of comparative sample 2 was 225. That is, it was found that the white jellyfish polysaccharide and the existing sample 1 had a much lower turbidity and higher transparency than the comparative samples 1 and 2.

[0223] In addition, as shown in Fig. 7 (a), the above measurement results show that the turbidity of sample 1 (35 degrees) is determined by placing the cosmetic of sample 1 in a transparent container. Change the thickness (thickness) to 5cm When the bottom of the container was visually observed from the top of the cosmetic, the numbers printed on the bottom of the container (size: 11 points, font: century) were easily visible. On the other hand, the turbidity of comparative sample 1 (185 degrees) and the turbidity of comparative sample 2 (225 degrees), as shown in Fig. 7 (a) and Fig. 7 (b), The numbers were completely unreadable.

 [0224] From the above results, it can be understood that the white jellyfish polysaccharide can be dissolved in both an aqueous medium and an oily medium by coexisting with polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether. Tsutsu.

 Evaluation Test Example 21 (Evaluation of change over time in particle diameter after pressure treatment)

 (1) Evaluation of differences due to formulation

 (Pressure treatment)

 Instead of Cream B2g in Formulation Example 13, Example 3 in Formulation Example 18 and the cosmetic liquid E2g in Comparative Examples 6-9 and 12 were used in the same manner as the pressure treatment in Evaluation Test Example 17 Got a sampnore.

 [0225] Thus, among the cosmetic liquid E of Prescription Example 18, each sample consisting of Example 3 and Comparative Examples 6 to 9 and 12 was set so that the temperature of the cosmetic liquid E would be 32 ° C, and 90 MPa The pressure was applied for 30 minutes.

 (Observation over time)

 The average particle size of serum B was measured before pressurization and after the lapse of 15 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 8 hours and 24 hours from the end of the pressure treatment. The results are shown in Table 66 and Table 67.

 [0226] For the measurement of the average particle size, a sample prepared by diluting cosmetic liquid E with distilled water to 0.5% by weight was used. The average particle size is measured with a laser diffraction / scattering type particle size distribution measuring instrument “LA-920 type” (manufactured by Horiba, Ltd.). The amount was set to 70 to 95%, and the measurement was started after the transparency was stabilized. The measurement result was a median diameter.

 [0227] (Sensory evaluation)

As a sensory evaluation after pressure treatment for each sample, the evaluation test example 19 (1)

First ¾ 967l

Table 66

 <Evaluation Test Example 21 (1): Evaluation of Beauty Liquid E (Formulation Example 18)> Processing pressure: 90 MPa, processing time: 30 minutes, processing temperature 32 ° C

 Change in particle diameter (ju m) over time Sensory evaluation

 Elapsed time after pressure treatment

 Before treatment 15 minutes Time 2 hours 3 hours 4 hours 8 hours 24 hours Improvement effect Effect

 Example 3 2.19 2.11 2.14 2.42 2.80 2.85 2.98 2.97 AA AA

 Comparative Example 6 2.64 2.62 270 2.84 2.90 2.80 2.81 2.82 A A

 Comparative Example 7 3.50 3.45 3.48 3.51 3.53 3.54 3.54 3.53 A A

 Comparative example 8 3.53 3.50 3.55 3.60 3.60 3.61 3.61 3.61 A A

 Comparative Example 9 2.70 2.66 2.71 2.85 2.95 2.94 2.94 2.93 A A

 Comparative Example 10 2.35 2.35 2.33 2.32 2.32 2.32 2.33 2.33 A— A—

 Comparative Example 11 3.08 3.08 3.07 3.07 3.07 3.07 3.08 3.08 A— A—

 Comparative Example 12 3.31 3.35 3.40 3.41 3.41 3.42 3.42 3.42 A- A-

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[0230] In Table 66, “AA” is extremely effective, “A” is effective, “A—” is somewhat effective, and “B” indicates no effect.

 As shown in Table 66 and Table 67, among the cosmetic liquid E of Formulation Example 18, for the formulation of Example 3, both the decrease in particle size due to pressurization and the subsequent restoration of the particle size were significant. there were. In addition, the effect of improving wrinkles and the lift-up effect were extremely good.

[0231] On the other hand, for the formulations of Comparative Examples 6 to 9 and 12, the decrease in the particle size due to pressurization, Although later restoration of particle size was observed, it was not as marked as in Example 3. The improvement effect and lift-up effect of shii were relatively good.

 (2) Evaluation of differences due to pressure conditions

 (Pressure treatment)

 In the prescription example 18, the cosmetic liquid E2g of Example 3 is put into a small-capacity heat seal bag (UNIPACK A-4, manufactured by Nippon Nihonsha), deaerated, and then heat sealed (desktop vacuum sealer for business use) SQ-202, manufactured by Sharp Corporation) was used for sealing. The sealed small-capacity heat-seal bag is packed into the large-capacity heat-seal bag (Yunipak F-4, manufactured by Nihon Shokuhin Co., Ltd.) for the number of measurements, and using the heat-seal device A large-capacity heat seal bag was sealed and used as a sample.

 [0232] Thus, when each sample consisting of Essence Liquid E of Example 3 has a processing pressure of lOOMPa or less, a hydrostatic press (water tank capacity: 8L, design pressure: max. 100MPa, design temperature: max. 75 ° C) When the processing pressure exceeds lOOMPa, press machine using cold isostatic pressing (CIP) (pressure tank capacity: 10L, design pressure: 0-50 OMPa, (Design temperature: 0 to 100 ° C.) Further, each sample was set so that the temperature of the emulsion was 32 ° C., and pressurized at a pressure of 90 MPa for 30 minutes.

 [0233] (Observation over time)

 The average particle size of serum E was measured before pressurization and after 15 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 8 hours and 24 hours from the end of the pressure treatment. The method for measuring the average particle size is the same as the method for measuring the average particle size in Evaluation Test 21 (1). The measurement results are shown in Table 68 and Table 69.

 [0234] (Sensory evaluation)

 As the sensory evaluation after the pressure treatment on the sample, sensory evaluation was performed in the same manner as in “Test improvement” and “lift-up effect” in Evaluation Test Example 19 (1). The results are also shown in Table 68.

[0235] [Table 68]

Table 68

 Evaluation test example 21 (2): Evaluation of Example 3 of serum E (formulation example 18)> Processing time: 30 minutes, processing temperature 32¾

 Temporal change of particle size (Xim) Sensory evaluation Elapsed time after pressure treatment

 Processing pressure 15 minutes 1 hour 2 hours 3 hours 4 hours 8 hours 24 hours Improvement effect Effect

90 Pa 2.19 2.11 2.14 2.42 2.80 2.85 2.98 2.97 AA AA

150 MPa 3.14 3.00 3.05 3.02 3.02 3.02 3.12 3.12 A A

200 MPa 3.14 3.04 3.06 3.06 3.07 3.06 3.08 3.08 A— A—

300 MPa 3.01 2.15 2.15 2.14 2.14 2.13 2.10 2.10 B B

500 MPa 3,01 2.03 2.03 2.02 2.02 2.02 2.02 2.02 BB

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In Table 68, “AA” is extremely effective, “A” is effective, “A—” is somewhat effective, and “B” indicates no effect.

As shown in Table 68 and Table 69, when the treatment pressure for the cosmetic liquid E of Example 3 is 90 MPa, the particle diameter of the cosmetic liquid E is significantly reduced by pressurization, and the particle diameter is reduced. It was possible to restore over time. Even when the treatment pressure was 150 MPa, the particle size of Essence E could be reduced by pressurization, and the particle size could be restored over time. . In all cases, after 8 hours have elapsed from the end of the pressurization process, the particle size of serum E becomes larger than that immediately after the end of the pressurization process (after 15 minutes), and almost no change has occurred. It is in a state that does not become. Therefore, from this result, it was found that the pressure-treated cosmetic is preferably applied to the skin or hair within 8 hours after the pressure treatment.

 [0238] On the other hand, when the treatment pressure was 200, 300, and 500 MPa, the recovery of the particle size over time after the pressure treatment was not observed. Therefore, from this result, it was found that if the degree of pressurization during pressurization is too large, the effect of restoring the particle size over time cannot be obtained. Although the above invention has been provided as an exemplary embodiment of the present invention, this is merely an example and should not be interpreted in a limited manner. Modifications of the present invention apparent to those skilled in the art to which the invention belongs will fall within the scope of the following claims. Industrial applicability

[0239] The method of using the cosmetic composition of the present invention is suitable as a skin care cosmetic composition for obtaining effects such as wrinkle improvement, lift-up effect, transparency enhancement effect, hair growth effect, anti-inflammatory effect and the like. is there. Further, the cosmetic of the present invention is suitable, for example, as an oily cosmetic that retains the moisturizing effect expressed by the white jellyfish polysaccharide, specifically, as a makeup cosmetic or a skin care cosmetic containing the white jellyfish polysaccharide. It is. Moreover, the cosmetic of the present invention is a skin care cosmetic for obtaining effects such as wrinkle improvement, lift-up effect, transparency improvement effect, hair growth effect, anti-inflammatory effect, etc., through a predetermined pressure treatment. Is preferred.

Claims

The scope of the claims

 [1] Cosmetics characterized in that the cosmetic is pressure-treated at 50 to 190 MPa for 15 minutes or more, and the cosmetic after pressure treatment is applied to the skin or hair within 8 hours after the pressure treatment. How to use the fee.

 [2] The method of using a cosmetic according to claim 1, wherein in the pressure treatment, the cosmetic is heated to 10 to 50 ° C. A cosmetic comprising glyceryl ether.

[4] The cosmetic according to claim 3, which is used for application to skin or hair within 8 hours after pressurizing at 50 to 190 MPa for 15 minutes or more.