JP2015214511A - Chemical composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a chemical composition available as cosmetics exerting excellent wrinkle/stain removing effect and whitening effect, hair restoring agents which may exert a high restoring effect by using only once even to the hair with a large degree of damage, skin care lotions which exhibit excellent wrinkle/stain removing effect, whitening effect, sunburn prevention effect, and dermatitis improving effect, highly practical hair tonic which exhibits sufficient hair growth effect by short-term use, liquid for permanent wave which can effectively give gloss, tension, and moisture to the hair by reducing the hair damages and adverse influences to the skin, and the like.SOLUTION: A chemical composition is prepared by mixing propolis, glycerin, aromatic, amino acid (a mixture of L-cysteine, L-arginine, L-tryptophan, L-lysine (hydrochloride), and L-aspartic acid), absorbable hyaluronic acid, fucoidan, and purified water at a given ratio, and sufficiently stirring.

Description

  The present invention relates to cosmetics such as skin creams, lotions, skin lotions, and emulsions, and more particularly to cosmetics that can exhibit excellent wrinkle / stain removal effects and whitening effects. The present invention also relates to a hair repair agent for repairing hair damage caused by chemical treatment of hair (permanent treatment, bleaching treatment, hair dyeing treatment, etc.) or heating. Furthermore, the present invention relates to lotions such as creams, lotions, and emulsions used for skin care, and more specifically, excellent wrinkle and stain removal effects, whitening effects, sun protection effects, dermatitis improvement effects It is related with the lotion for skin care which can express. In addition, the present invention provides a permanent liquid capable of imparting luster, firmness and moisture to the hair while suppressing damage to the hair when the hair is permanently treated, and changing the shape of the hair and decolorizing the hair. Alternatively, it can be added to the hair treatment agent for coloring, and when the hair is treated with the hair treatment agent, the hair conditioner can be used to suppress hair damage and give the hair gloss, firmness and moisture. It is about.

  Anti-aging agents such as vitamin C, vitamin E, SOD (superoxide dismutase), catalase, and anti-glycyrrhizic acid, etc. as cosmetics to prevent facial skin aging and develop wrinkle and stain removal effects and whitening effects Inflammatory agents, various UV absorbers, α-hydroxycarboxylic acid, placenta extract, cell activation components such as γ-amino-β-hydroxybutyric acid, extracellular matrix components such as collagen, elastin, hyaluronic acid, moisturizing urea, etc. Those containing an agent or the like are known. In addition, as disclosed in Patent Document 1, one containing a physiologically active ingredient has been proposed.

  In addition, the so-called permanent liquid for applying permanent to hair imparts a wave to hair or corrects curly hair and hair by oxidizing after reducing the hair. Cuticle peeling, split hair, broken hair, broken hair, porous hair, carbonized hair, and the like are easily damaged. In addition, permanent treatment by heating the hair is liable to damage the hair. Therefore, a restorative agent for repairing damaged hair has been developed. As a composition used for the restorative agent, a hair restorative agent containing hydrolyzed keratin and inositol hexaphosphate has been developed as disclosed in Patent Document 2. Has been.

  On the other hand, as a skin care lotion to prevent facial skin aging and develop wrinkle / stain removal and whitening effects, vitamin C, vitamin E, SOD (superoxide dismutase), catalase and other antioxidants, glycyrrhizic acid Anti-inflammatory agents such as, various UV absorbers, α-hydroxycarboxylic acid, placental extract, cell activation components such as γ-amino-β-hydroxybutyric acid, extracellular matrix components such as collagen, elastin, hyaluronic acid, urea A material containing a moisturizing agent or the like is known. In addition, as disclosed in Patent Document 3, one containing a physiologically active ingredient has been proposed.

  In addition, conventional hair restorers include those expected to have a hair growth action by inhibiting the activation of male hormones or increasing blood flow in capillaries, and such hair restorers include those having 5 to 5 carbon atoms. An aliphatic monohydric alcohol having an odd carbon chain length of 25, or an esterified or etherified product thereof is known as an active ingredient. In addition, as a hair restoration agent for the purpose of supplying nutrition to the hair root, promoting blood circulation, cell activation, etc., as in Patent Document 4, those containing pentadecanoic acid glyceride as the main component, carpronium chloride, adenosine, minoxidil, etc. The thing which has as a main component is also known.

  On the other hand, the liquid for applying permanent to the hair (so-called permanent liquid) is to oxidize after reducing the hair, thereby imparting waves to the hair or correcting curly hair or crushed hair. . However, since the perm solution exposes the hair to severe conditions such as reduction and oxidation, it tends to cause damage to the hair such as cuticle peeling, split ends, and broken hair. In addition, bleaching agents for decolorizing the hair are decolorized mainly by decomposing the melanin pigment in the hair by an oxidizing action by an oxidizing agent such as hydrogen peroxide. Like, it can damage your hair. Hair dyes, on the other hand, cause hair coloring by allowing the dye precursor to penetrate into the hair and oxidizing and polymerizing the dye precursor. Similarly, it may lead to hair damage. In addition, these hair treatment agents such as perm liquids, bleaching agents, and hair coloring agents may adversely affect the skin, such as rashes, by chemical action. In order to eliminate the damage to the hair and the adverse effects on the skin caused by such a hair treatment agent, as disclosed in Patent Document 5, a method of using a damage preventing component such as a protein hydrolyzate in combination with the hair treatment agent has been developed.

JP 2009-120521 A JP-A-10-175824 JP 2009-120521 A JP-A-6-40857 JP 2003-55169 A

  However, it cannot be said that the above-mentioned conventional cosmetics have sufficient wrinkle / stain removal effect and whitening effect. Further, when the amount used is increased in order to develop a sufficient wrinkle / smear removing effect and whitening effect, irritation to the skin becomes stronger, and in some cases, the skin may be inflamed.

  In addition, the conventional hair repairing agent such as Patent Document 2 exhibits a certain degree of repairing effect on hair with a low degree of damage, but cannot exhibit a sufficient repairing effect on hair with a large degree of damage. There is a problem that.

  On the other hand, the conventional skin care lotion as disclosed in Patent Document 3 does not necessarily have sufficient wrinkle / scratch removal effect and whitening effect. In addition, when the amount used is increased in order to exhibit a sufficient wrinkle / smear removing effect and whitening effect, irritation to the skin becomes stronger, and in some cases, the skin may become inflamed.

  Moreover, the conventional hair restorer like patent document 4 is still not enough in the hair-growth effect (especially the effect based on a short-term use).

  In addition, the hair treatment agent containing an ingredient for preventing damage such as protein hydrolyzate as described in Patent Document 5 can alleviate the hair damage such as cuticle peeling, split hair, and cut hair, and adverse effects on the skin to some extent. Although possible, it is difficult to say that the effect is sufficient.

  The object of the present invention is to solve the problems of the above-mentioned conventional cosmetics and to exhibit an excellent wrinkle / smear removing effect and whitening effect, and also less irritation to the skin even if the amount used is increased. The object is to provide highly safe cosmetics.

  In addition, the object of the present invention is to solve the problems of the above-mentioned conventional hair repairing agents, and to make epoch-making hair that can exhibit a high repairing effect by using once even for hair with a large degree of damage. It is to provide a repair agent.

  Furthermore, the object of the present invention is to solve the problems of the conventional skin care lotion and not only have an excellent wrinkle / stain removal effect and whitening effect, but also an anti-sun effect, dermatitis (atopic dermatitis, etc.) It is to provide a skin care lotion with high practicality that also exhibits an improvement effect.

  In addition, an object of the present invention is to provide a highly practical hair restorer that exhibits a sufficient hair-growth effect when used for a short period of time.

  In addition, the object of the present invention is to solve the problems of the above-mentioned conventional perm solution, suppress damage to the hair and adverse effects on the skin, and effectively impart luster, firmness and moisture to the hair. Another object of the present invention is to provide a practical permanent liquid that can be manufactured at low cost. Furthermore, the object of the present invention is to eliminate the problems of the conventional hair treatment agent described above, and by adding to the hair treatment agent, suppressing damage to the hair and adverse effects on the skin, the hair is glossy, firm and moisturized. An object of the present invention is to provide a practical hair conditioner that can be effectively applied and can be produced at low cost.

  Among the present inventions, the invention described in claim 1 is a chemical composition that can be used as a cosmetic, a hair repair agent, a skin care lotion, a hair restorer, a perm solution, or a hair conditioner, comprising a propolis, an amino acid It is characterized by containing.

  The invention described in claim 2 is characterized in that, in the invention described in claim 1, at least a part of the amino acid is cystine bound to hydrolyzed keratin by platinum.

  The invention described in claim 3 is a cosmetic comprising propolis and an amino acid.

  The invention described in claim 4 is the invention described in claim 3, wherein the amino acid is arginine, cysteine, cystine, lysine, threonine, aspartic acid, GABA, or a derivative thereof, or 2 It is characterized by being a mixture of seeds or more.

  The invention described in claim 5 is characterized in that, in the invention described in claim 3 or claim 4, at least a part of cystine is bound to hydrolyzed keratin by platinum. is there.

  The invention described in claim 6 is the invention described in any one of claims 3 to 5, wherein silver ions, zinc ions, titanium ions, or one or more heavy metal ions thereof are used. It is characterized by mixing.

  The invention described in claim 7 is characterized in that in the invention described in any of claims 3 to 6, it contains hyaluronic acid.

  The invention described in claim 8 is characterized in that in the invention described in any of claims 3 to 7, fucoidan is contained.

  The invention described in claim 9 is characterized in that, in the invention described in any one of claims 3 to 8, the addition ratio of propolis to amino acid is 0.1% or more and less than 100%. is there.

  The invention described in claim 10 is a hair repairing agent for repairing damage caused by chemical treatment of hair, and is characterized by containing propolis.

  The invention described in claim 11 is the invention described in claim 10, characterized by containing fucoidan.

  The invention described in claim 12 is characterized in that it contains an amino acid or a derivative thereof in the invention described in claim 10 or claim 11.

  The invention described in claim 13 is the invention described in any one of claims 10 to 12, characterized by containing hyaluronic acid or a derivative thereof.

  The invention described in claim 14 is the invention described in any one of claims 10 to 13, wherein the amino acid is one or more of cysteine, cystine, lysine, arginine or a derivative thereof. It is characterized by being a mixture.

  The invention described in claim 15 is characterized in that, in the invention described in any one of claims 14, at least a part of cystine is bonded to hydrolyzed keratin by platinum.

  The invention described in claim 16 is a lotion such as cream, lotion, milky lotion and the like used for skin care, characterized in that it contains propolis and amino acids.

  The invention described in claim 17 is the invention described in claim 16, wherein the amino acid is one of cysteine, cystine, arginine, lysine or a derivative thereof, or a mixture of two or more thereof. It is characterized by being.

  The invention described in claim 18 is characterized in that in the invention described in claim 16 or claim 17, at least a part of cystine is bound to hydrolyzed keratin by platinum. is there.

  The invention described in claim 19 is characterized in that in the invention described in any of claims 16 to 18, it contains hyaluronic acid.

  The invention described in claim 20 is characterized in that in the invention described in any of claims 16 to 19, fucoidan is contained.

  The invention described in claim 21 is characterized in that, in the invention described in any of claims 16 to 20, the addition ratio of propolis to amino acid is 5% or more and less than 20%.

  The invention described in claim 22 is a hair restorer characterized by containing a propolis and an amino acid.

  The invention described in claim 23 is characterized in that, in the invention described in claim 22, at least a part of the amino acid is cystine bound to hydrolyzed keratin by platinum.

  The invention described in claim 24 is a permanent solution for changing the shape of the hair by attaching it to the hair, to which propolis and cystine or acetylcysteine combined with hydrolyzed keratin by platinum are added. It is characterized by this.

  In the invention described in claim 25, in the invention described in claim 24, an amino acid formed by mixing one or more of arginine, cysteine, cystine, lysine or derivatives thereof is added. It is characterized by being.

  The invention described in claim 26 is a hair conditioner added to a hair treatment agent for changing the shape of hair, decolorizing or coloring the hair, and hydrolyzed keratin by propolis and platinum. Is added with cystine or acetylcysteine bound to the. The hair treatment agent includes a perm solution, a bleaching agent, a hair dye (a hair coloring agent or a hair dye), a treatment, a conditioner, and the like.

  The cosmetic according to the present invention has an excellent wrinkle removing effect, skin beautification, and whitening effect. In addition, even when used for a long period of time, the skin is not damaged and safety is high.

  In addition, according to the hair repairing agent according to the present invention, a high repairing effect can be achieved by using once for hair with a large degree of damage, and there is no split hair, porous hair, carbonized hair, etc., and gloss and firmness. It is possible to repair certain hair.

  On the other hand, the lotion for skin care according to the present invention has excellent wrinkle removing action, skin beautification and whitening action. In addition, it is possible to effectively prevent sunburn by simply applying it thinly on the face and limbs, which is effective in suppressing the onset of skin cancer and improving the symptoms of skin cancer. In addition, it has an excellent effect in improving the symptoms of dermatitis (atopic dermatitis and the like).

  In addition, the hair restorer according to the present invention can exhibit excellent hair growth / hair growth / hair growth effect without adversely affecting the scalp and the like by simply using and applying it to the scalp and the like for a short period of time.

  On the other hand, the permanent solution according to the present invention has good ridge coverage when the hair is permanently treated, and can suppress damage to the hair and impart sufficient gloss, firmness and moisture to the hair.

  In addition, the hair conditioner according to the present invention, when treating the hair with a hair treatment agent (permanent treatment, decoloring or coloring treatment), just adding to the hair treatment agent, suppressing damage to the hair, Sufficient luster, firmness and moisture can be given to the hair. That is, when the hair conditioner according to the present invention is added to the permanent solution, the ridge is improved, and the hair is glossy, firm and moist, and can be made supple. Moreover, when the hair conditioner according to the present invention is added to the hair dye, it can be finished in a good state with no color spots. Furthermore, when the hair conditioner according to the present invention is added to a bleaching agent or a hair dye, irritation to the skin during decolorization or hair dyeing can be suppressed. In addition, when the hair conditioner according to the present invention is added to a treatment or conditioner, the hair can be maintained in a supple state with gloss, firmness and moisture over a long period of time. In addition, once the hair is dried, it is possible to further impart luster, firmness and moisture to the hair by applying heat again with an iron or the like.

[Embodiment of Cosmetics]
Hereinafter, embodiments of the cosmetic according to the present invention will be described in detail. In the following description, “˜” relating to the content and addition amount of each component basically means a numerical value on the left side or more and less than a numerical value on the right side. The cosmetic according to the present invention is characterized by containing a propolis and an amino acid. In addition, Propolis as used in the present invention (a chemical composition usable as a cosmetic, hair repair agent, skin care lotion, hair restorer, perm solution, hair conditioner) refers to various substances secreted by plants. It is a sticky substance that honeybees collect and use for nesting, so-called bee crabs. The cosmetic according to the present invention preferably contains an extraction solution (ethanol solution or the like) having a solid content concentration of 10% to 30% in an amount of 0.01 to 15% by mass, and 3.0 to 10% by mass. (Thus, the solid content concentration is preferably 0.001% to 4.5% by mass, more preferably 0.3% to 3.0% by mass. ). As the propolis extraction solution, it is most preferable to use an extraction solution having a solid concentration of about 20%. If the added amount of propolis is less than the above range (solid content concentration is less than 0.001% by mass), it is not preferable because sufficient wrinkle / stain removal effect, skin beautification / whitening effect cannot be obtained. If the added amount exceeds the above-mentioned range (solid content concentration exceeds 4.5% by mass), it is uneconomical, the feeling of stickiness when applied to the skin is increased, and the odor of cosmetics is increased. Since it becomes defective, it is not preferable.

  Further, the cosmetic according to the present invention needs to contain an amino acid. Such amino acids include alanine, arginine, asparagine, aspartic acid, cysteine (or cystine), glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine (also referred to as lysine), methionine, phenylalanine, proline, serine, threonine. , Tryptophan, tyrosine, valine, GABA (γ-aminobutyric acid), 21 types of amino acids, L-type amino acids, or derivatives thereof such as hydrochloride, sulfate, etc. can be used. Arginine, cysteine ( Or cystine), lysine, threonine, aspartic acid, GABA, or a mixture of two or more of these derivatives, the hair can be efficiently polished, It becomes possible to add moisture Since preferred. In addition, it is preferable to use a mixture of cysteine, arginine, and lysine because a very high wrinkle / stain removal effect and skin / whitening effect can be obtained. Moreover, as an amino acid used with the propolis in the cosmetics according to the present invention, cysteine (L-cysteine), arginine (L-arginine), lysine (L-lysine), or a hydrochloride thereof (or one or two of them) Use of a combination of at least seeds is preferable because an extremely high wrinkle / smear removing effect and a skin beautifying / whitening effect can be obtained.

  Furthermore, when cystine is used as an amino acid, dispersibility of cystine in cosmetics is improved (precipitated) if at least a part (or all) of the cystine is bound to hydrolyzed keratin by platinum. This is preferable because “paste” on the skin is improved. The platinum in the present invention is a so-called platinum (platinum) nanocolloid in which platinum (platinum) is made into ultrafine particles down to the nano level (parts of 1 billion to 3 parts per billion). In the production of cosmetics, it is preferable to use cystine (hereinafter referred to as improved cystine) conjugated with hydrolyzed keratin by such platinum (via platinum). Platinum in such improved cystine exhibits a high antioxidant effect, and contributes to the effect of removing wrinkles / stains, skin beautification / whitening by interacting with propolis and cystine (or other amino acids).

  Moreover, when using the above-described improved cystine, the content of the cystine is not particularly limited, but is preferably 0.005 to 5% by mass in terms of solid content, and 0.01 to 2% by mass More preferably. If the content of the improved cystine is less than 0.005% by mass, it is not preferable because sufficient wrinkle / stain removal effect, skin beautification / whitening effect cannot be obtained, and the content of the improved cystine is 5% by mass. Exceeding this is not preferable because it is uneconomical and may irritate the skin.

  Further, when the above-described improved cystine is used, when the content of the cystine is adjusted within a range of 10% to 200% (weight ratio in terms of solid content) with respect to the added amount of propolis, higher antioxidant is achieved. Since it is possible to exert a very good wrinkle / stain removal effect, skin beautification / whitening effect by interacting with propolis, it is preferable to adjust it within the range of 20% to 100%. It is particularly preferable to adjust within the range of 30% to 70%.

  Furthermore, when the above-described improved cystine is used, the amount of platinum (platinum nanocolloid) added to cystine is adjusted within the range of 0.01% to 1.0% (weight ratio in terms of solid content). It is preferable because the dispersibility of cystine is good, and it is more preferable to adjust within the range of 0.1% to 0.5%, particularly when adjusted to within the range of 0.2% to 0.3%. preferable. In addition, when improved cystine is used, the dispersibility of cystine in cosmetics can be improved by adjusting the content of cystine to hydrolyzed keratin within the range of 1% to 50% (weight ratio in terms of solid content). Since it becomes favorable, it is preferable to adjust within the range of 3% to 25%, more preferable to adjust within the range of 5% to 10%. Further, when improved cystine is used, the cystine is preferably used as an aqueous solution having a solid content concentration of 1 to 5% by mass, and most preferably used as an aqueous solution having a solid content concentration of 2% by mass.

  As amino acids to be contained in cosmetics, acetylcysteine (N-acetyl-L-cystein), N, N′-bisacetylcystine (N, N′-diacetylcystine (N, N ′) -diacetyl-L-cystine)), N-acetyl-L-cystine, and cysteic-acid can be used. Among them, acetylcysteine is used to remove wrinkles and stains. The skin beautifying / whitening effect is very good, which is preferable.

  The cosmetic according to the present invention preferably contains 0.05 to 10% by mass, more preferably 0.1 to 5% by mass of the above-described amino acid (or a derivative thereof) as a whole. If the content of the amino acid or its derivative is below the above range, it is not preferable because a synergistic effect with propolis cannot be obtained, and sufficient wrinkle / stain removal effect, skin beautification / whitening effect cannot be obtained. If the content of the derivative exceeds the above-mentioned range, it is not preferable because it is not economical and may cause irritation to the skin.

  Furthermore, the cosmetic according to the present invention can contain heavy metal ions as an antibacterial component. As such heavy metal ions, various types of ions can be used. Silver ions, zinc ions, titanium ions, or one of them, or a mixture of two or more thereof can be highly wrinkled. It is preferable because it can provide a stain removal effect, a skin beautifying / whitening effect. In addition, the use of composite metal ions of silver ions, zinc ions, and titanium ions is more preferable because the effect of removing wrinkles and stains and the effect of beautifying and whitening the skin are further improved. The content of heavy metal ions is not particularly limited, but is preferably 0.1 to 10% by mass, and more preferably 0.5 to 5% by mass. If the content of heavy metal ions is below the above range, it is not preferable because sufficient wrinkle / stain removal effect, skin beautification / whitening effect cannot be obtained, and if the content of heavy metal ions exceeds the above range, In addition to being uneconomical, there is a possibility that the skin irritation may be strengthened.

  On the other hand, the addition ratio of propolis (pure component) to amino acid in the cosmetic according to the present invention is not particularly limited, but when the addition ratio is 0.1% or more and less than 100%, the synergy between propolis and amino acid Since higher wrinkle / stain removal effect and skin beautification / whitening effect can be obtained, it is preferably 5% to 50%, more preferably 10% to 30%.

  In addition to the essential components propolis and amino acids, the cosmetics according to the present invention include components usually used in cosmetics such as oily components, synthetic or natural surfactants, moisturizers, A sticking agent, antiseptic / bactericidal agent, powder component, ultraviolet absorber, antioxidant, pigment, fragrance and the like can be appropriately blended as necessary. In addition, the cosmetics according to the present invention include various alcohols, fermented alcohols, glycols (such as butyl glycol), extracts extracted from plants, preservatives, fragrances, viscosity modifiers, pH adjusters as necessary. Etc. can also be added.

  Examples of oil components include olive oil, jojoba oil, castor oil, soybean oil, rice oil, rice germ oil, coconut oil, palm oil, cacao oil, meadow foam oil, sheer butter, tea tree oil, avocado oil, macadamia nut oil Plant-derived fats and oils such as plant-derived squalane; animal-derived fats and oils such as mink oil and turtle oil; waxes such as beeswax, carnauba wax, rice wax and lanolin; carbonization such as liquid paraffin, petrolatum, paraffin wax and squalane Hydrogen; fatty acids such as myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, cis-11-eicosenoic acid; higher alcohols such as lauryl alcohol, cetanol, stearyl alcohol; isopropyl myristate, isopropyl palmitate, oleic Butyl, 2-ethylhexyl glycerides, etc. can be suitably used synthetic esters and synthetic triglycerides, such as higher fatty octyldodecyl (octyl stearate dodecyl).

  Examples of the surfactant include polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, Nonionic surfactants such as polyoxyethylene sorbitol fatty acid esters; fatty acid salts, alkyl sulfates, alkylbenzene sulfonates, polyoxyethylene alkyl ether sulfates, polyoxyethylene fatty amine sulfates, polyoxyethylene alkyl phenyl ether sulfates , Polyoxyethylene alkyl ether phosphates, α-sulfonated fatty acid alkyl ester salts, polyoxyethylene alkyl phenyl ether phosphates, etc. Nonionic surfactant: quaternary ammonium salt, primary to tertiary fatty amine salt, trialkylbenzylammonium salt, alkylpyridinium salt, 2-alkyl-1-alkyl-1-hydroxyethylimidazolinium salt, N N, N-dimethyl-N-alkyl-N-carboxymethylammoniobetaine, N, N, N-trialkyl-N-, N, N-dimethyl-N-alkyl-N-carboxymethylammoniobetaine Amphoteric surfactants such as alkylene ammoniocarboxybetaine and N-acylamidopropyl-N ′, N′-dimethyl-N′-β-hydroxypropylammoniosulfobetaine can be used.

  In addition, as emulsifiers and emulsifiers, stevia derivatives such as enzyme-treated stevia, lecithin and derivatives thereof, lactic acid bacteria fermented rice, lactic acid bacteria fermented rice, lactic acid bacteria fermented cereals (wheat, legumes, miscellaneous grains, etc.), juzairo (Rhamnaceae zizyphus joazeiro) An extract or the like can also be blended.

  Examples of the humectant include glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, polyethylene glycol, sorbitol, xylitol, sodium pyrrolidonecarboxylate, and sugars such as trehalose, lactic acid bacteria fermented rice, mucopoly Sugars (for example, hyaluronic acid and its derivatives, chondroitin and its derivatives, heparin and its derivatives, etc.), elastin and its derivatives, collagen and its derivatives, NMF related substances, lactic acid, urea, higher fatty acid octyldodecyl, seaweed extract, seaweed extract Examples include extracts, seafood-derived collagen and derivatives thereof, various amino acids and derivatives thereof.

  Examples of the thickener include brown algae, green algae or red algae-derived components such as alginic acid, agar, carrageenan and fucoidan; beech extract; polysaccharides such as pectin, locust bean gum and aloe polysaccharide; xanthan gum, tragacanth gum, guar gum and the like Gums such as carboxymethylcellulose, hydroxyethylcellulose, etc .; synthetic polymers such as polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, acrylic acid / methacrylic acid copolymer; hyaluronic acid and derivatives thereof; polyglutamic acid and derivatives thereof Etc. can be used suitably.

  Examples of the antiseptic / bactericidal agent include urea; paraoxybenzoates such as methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, and butyl paraoxybenzoate; phenoxyethanol, dichlorophene, hexachlorophene, chlorhexidine hydrochloride, chloride Benzalkonium, salicylic acid, ethanol, undecylenic acid, phenols, jamal (imidazodenyl urea), 1,2-pentanediol, various essential oils, bark dry matter and the like can be suitably used.

  Examples of powder components include sericite, titanium oxide, talc, kaolin, bentonite, zinc oxide, magnesium carbonate, magnesium oxide, zirconium oxide, barium sulfate, silicic anhydride, mica, nylon powder, polyethylene powder, silk powder, Cellulose powder, powder of cereals (rice, wheat, corn, millet, etc.), powder of beans (soybean, red beans, etc.), etc. can be suitably used.

  Examples of the UV absorber include ethyl paraaminobenzoate, ethylhexyl paradimethylaminobenzoate, amyl salicylate and derivatives thereof, 2-ethylhexyl paramethoxycinnamate, octyl cinnamate, oxybenzone, 2,4-dihydroxybenzophenone, 2-hydroxy- 4-methoxybenzophenone-5-sulfonate, 4-tertiarybutyl-4-methoxybenzoylmethane, 2- (2-hydroxy-5-methylphenyl) benzotriazole, urocanic acid, ethyl urocanate, aloe extract, etc. It can be used suitably.

  As the antioxidant, for example, butylhydroxyanisole, butylhydroxytoluene, propyl gallate, vitamin E and its derivatives, beech extract, rice extract and the like can be suitably used.

  Furthermore, it is possible to add a moisturizing agent (moisture adjusting agent) such as hyaluronic acid (especially absorption hyaluronic acid, for example, hydroxypropyltrimonium hyaluronate) to the cosmetic according to the present invention, if necessary. It is. In addition, when adding hyaluronic acid to the cosmetics according to the present invention, the addition amount is not particularly limited, but is preferably 0.005 to 5% by mass from the viewpoint of skin moisturizing property and economic efficiency, It is more preferable in it being 0.05-2 mass%.

  In addition, when the fucoidan (a dietary fiber that is a kind of sulfated polysaccharide and is abundant in mucilage of brown algae such as kelp and seaweed) is added to the cosmetic according to the present invention, an antibacterial action prevents wrinkles and stains, It is preferable because the skin beautifying and whitening action is further improved. Although the amount of fucoidan added is not particularly limited, it is preferably 0.005 to 5% by mass from the viewpoints of wrinkle / stain removal, skin beautification / whitening and economic efficiency, and is 0.05 to 2% by mass. More preferably.

  In the production of the cosmetic according to the present invention, the production method is not particularly limited, but the raw material or a mixture of raw materials is heated within a temperature range of 30 ° C to 100 ° C as necessary. Is preferred.

[Example A: Examples of cosmetics]
Hereinafter, the cosmetics according to the present invention will be described in more detail with reference to examples. However, the present invention is not limited to the embodiments of the examples, and may be appropriately changed without departing from the spirit of the present invention. It is possible. Moreover, the evaluation methods of physical properties and characteristics in the examples are as follows. In the following sensory evaluations, the average stage (◎, ○, Δ, ×) of the evaluation results for the three subjects was used as the final evaluation result.

<Wrinkle removal and stain removal effect>
The cosmetics prepared in each Example and Comparative Example were used for 3 subjects (all in their 50s) by the following methods (1) to (4), and the use was made for a certain period (1 week). Repeated over.
(1) Application of a predetermined amount (about 5.0 g) of cosmetics to the face (application by hand)
(2) Sufficient rubbing into the skin (3) Holding for about 10 hours (4) Removal by a prior application using a commercial soap And, as described above, the face of each subject after repeated use of cosmetics The skin condition was sensory-evaluated in the following four stages.
○: A sufficient reduction effect is observed in the corners of the eyes, wrinkles on the forehead and skin spots.
Δ: Slight reduction effect is observed in the corners of the eyes, wrinkles of the forehead and skin spots.
×: Almost alleviating effect is not seen in the corners of the eyes, wrinkles of the forehead and skin spots

<Whitening effect>
The change in the skin color of the face of each subject after repeating the use of the cosmetic as described above over a certain period of time was subjected to sensory evaluation in the following four stages.
○: Sufficient whitening is observed on the skin of the entire face.
(Triangle | delta): Slight whitening is recognized by the skin of the whole face.
X: Whitening is not recognized in the skin of the whole face.

<Skin irritation>
When the use of the cosmetic as described above was repeated for a certain period, the skin irritation of each subject was sensory-evaluated in the following four stages.
○: No irritation to skin.
Δ: Slight irritation is felt.
X: A strong stimulus is felt.

<Smell of cosmetics>
The odor felt by the subject when the use of the cosmetic as described above was repeated over a certain period was sensory-evaluated in the following three stages.
○: No particular bad odor is felt.
Δ: A slight odor is felt.
X: A bad smell is felt.

<Solution uniformity>
The uniformity of the solutions of the cosmetics obtained in the examples and comparative examples was sensory-evaluated by the following three stages by visual observation.
A: There is no precipitate at all.
○: Some precipitate is observed.
Δ: Many precipitates are observed.

[Example A-1]
<Preparation of cosmetics>
The cosmetics of Example A-1 were obtained by mixing the following components. When producing cosmetics, the propolis solution and glycerin are mixed and stirred, while an amino acid is mixed and stirred in purified water heated to about 70 ° C., and the mixture is cooled to room temperature. Then, absorption hyaluronic acid was blended and stirred. Thereafter, after adding heavy metal ions to the resulting mixed aqueous solution of amino acid and absorption hyaluronic acid, the heavy metal ion-containing solution was mixed with the mixed solution of propolis solution and glycerin and stirred.

<Ingredients of cosmetics>
Propolis solution (20% by mass extract (ethanol solution)): 1.0% by mass (concentration of pure components of propolis = 0.2% by mass)
・ Glycerin: 70% by mass
-Fragrance: 0.2% by mass
・ Heavy metal ion ・ Composite ion of silver ion, zinc ion and titanium ion: 10,000 ppm
・ Amino acid ・ L-cysteine: 0.2% by mass
・ L-arginine: 0.2% by mass
L-threonine: 0.1% by mass
L-lysine (hydrochloride): 0.1% by mass
L-aspartic acid: 0.1% by mass
Absorbing hyaluronic acid (hydroxypropyltrimonium hyaluronate): 5.0% by mass
・ Fucoidan: 5.0% by mass
・ Purified water: remaining amount

  Thereafter, the above-described method is used for the three subjects with cosmetics for a certain period (one week), and the above-mentioned “wrinkle removal / smear removal effect”, “whitening effect”, “skin irritation” and Four items of “smell of cosmetics” were evaluated. The evaluation results are shown in Table 1 together with the composition of the cosmetic.

[Examples A-2 and A-3]
Example A-2 was prepared in the same manner as in the preparation of the cosmetic of Example A-1, except that when the cosmetic was prepared, the mixing ratio of heavy metal ions was changed to 5,000 ppm and 20,000 ppm, respectively. , A-3 cosmetics were prepared (the weight ratio (residual amount) of purified water was changed in accordance with the mixing ratio of heavy metal ions). And after using the cosmetics of those Examples A-2 and A-3 by the same method as in Example A-1, they were evaluated in the same manner as in Example A-1. The evaluation results are shown in Table 1 together with the composition of the cosmetic.

[Examples A-4 and A-5]
When preparing the cosmetics, the heavy metal ions were changed to silver ions and zinc ions, respectively, in the same manner as in the preparation of the cosmetics of Example A-1, and in Examples A-4 and A-5. A cosmetic was prepared. Then, the cosmetics of Examples A-4 and A-5 were evaluated in the same manner as in Example A-1 after being used for subjects in the same manner as in Example A-1. The evaluation results are shown in Table 1 together with the composition of the cosmetic.

[Examples A-6 to A-8]
When preparing cosmetics, the amino acids to be added were L-cysteine only, L-arginine only, and L-lysine (hydrochloride), respectively, and the mixing ratio thereof was changed to 0.7% by mass. The cosmetics of Examples A-6 to A-8 were prepared in the same manner as in the preparation of the cosmetic of Example A-1. Then, the cosmetics of Examples A-6 to A-8 were evaluated in the same manner as in Example A-1 after being used for subjects in the same manner as in Example A-1. The evaluation results are shown in Table 1 together with the composition of the cosmetic.

[Examples A-9 to A-12]
When preparing cosmetics, the mixing ratio of propolis (concentration of pure components of propolis) was changed to 0.025 mass%, 0.25 mass%, 0.5 mass%, and 2.5 mass%, respectively. The makeup of Example A-1 except that the concentration of the pure component of propolis was changed to 0.005% by mass, 0.05% by mass, 0.1% by mass, and 0.5% by mass, respectively. The cosmetics of Examples A-9 to A-12 were prepared in the same manner as the preparation of the materials. Then, the cosmetics of Examples A-9 to A-12 were evaluated in the same manner as in Example A-1 after being used for subjects in the same manner as in Example A-1. The evaluation results are shown in Table 1 together with the composition of the cosmetic.

[Example A-13]
<Preparation of cosmetics>
The cosmetics of Example A-13 were obtained by mixing the following components.

<Ingredients of cosmetics>
Propolis solution (20% by mass extract (ethanol solution)): 1.0% by mass (concentration of pure components of propolis = 0.2% by mass)
-Fragrance: 0.2% by mass
・ Dispersant: 3.0% by mass
-Aqueous solution of improved cystine (ie, cystine bound to hydrolyzed keratin by platinum) (aqueous solution having a cystine solid content concentration of 2.0%): 5.0% by mass
・ Other amino acids ・ L-arginine: 0.3% by mass
L-lysine (hydrochloride): 0.1% by mass
-Sodium hyaluronate: 30.0% by mass
Absorbing hyaluronic acid (hydroxypropyltrimonium hyaluronate): 3.0% by mass
・ Fucoidan: 3.0% by mass
-Preservative (ethoxydiglycol, phenoxyethanol, methylparaben, propylparaben, butylparaben, ethylparaben mixed solution): 0.1% by mass
・ Glycerin: 30.0% by mass
・ Purified water: remaining amount

  And after using for the test subject the cosmetics of obtained Example A-13 by the method similar to Example A-1, it evaluated similarly to Example A-1. The evaluation results are shown in Table 1 together with the composition of the cosmetic.

[Examples A-14 to A-16]
When preparing the cosmetic, the mixing ratio of the aqueous solution of improved cystine was changed to 3.0% by mass, 7.0% by mass, and 10.0% by mass, respectively (ie, the pure component of the improved cystine Example A-14 to Example A-13 were carried out in the same manner as in the preparation of the cosmetic of Example A-13 except that the concentrations were changed to 0.06% by mass, 0.14% by mass, and 0.2% by mass, respectively. A-16 cosmetic was prepared. And after using the cosmetics of those Examples A-14 to A-16 in the same manner as in Example A-1, they were evaluated in the same manner as in Example A-1. The evaluation results are shown in Table 1 together with the composition of the cosmetic.

[Example A-17]
Except for mixing 0.3 mass% of acetylcysteine in place of the improved cystine aqueous solution when preparing the cosmetic, the preparation of Example A-17 was the same as the preparation of the cosmetic of Example A-13. A cosmetic was prepared. And after using the cosmetics of Example A-17 for a test subject by the method similar to Example A-1, it evaluated similarly to Example A-1. The evaluation results are shown in Table 1 together with the composition of the cosmetic.

<Comparative Example A-1>
A cosmetic of Comparative Example A-1 was prepared in the same manner as the preparation of the cosmetic of Example A-1, except that no propolis was added when preparing the cosmetic. And after using the cosmetics of the comparative example A-1 to a test subject by the method similar to Example A-1, it evaluated similarly to Example A-1. The evaluation results are shown in Table 1 together with the composition of the cosmetic.

<Comparative Example A-2>
A cosmetic of Comparative Example A-2 was prepared in the same manner as the preparation of the cosmetic of Example A-1, except that no heavy metal ions were added when preparing the cosmetic. And after using the cosmetics of the comparative example A-2 by the test subject by the method similar to Example A-1, it evaluated similarly to Example A-1. The evaluation results are shown in Table 1 together with the composition of the cosmetic.

<Comparative Example A-3>
A cosmetic of Comparative Example A-3 was prepared in the same manner as the preparation of the cosmetic of Example A-1, except that no amino acid was added when preparing the cosmetic. And after using the cosmetics of the comparative example A-3 for a test subject by the method similar to Example A-1, it evaluated similarly to Example A-1. The evaluation results are shown in Table 1 together with the composition of the cosmetic.

  From Table 1, when the cosmetics of Examples A-1 to A-12 containing propolis, amino acids and heavy metal ions are used for a certain period of time, both the wrinkle removal / scratch removal effect and the whitening effect are good. Therefore, it can be seen that there is little irritation to the skin and the odor of the cosmetics is not worrisome during use. Moreover, even when the cosmetics of Examples A-13 to A-17 containing propolis and improved cystine (or acetylcysteine) are used for a certain period of time, both the wrinkle removal / scratch removal effect and the whitening effect are obtained. It is good and shows little irritation to the skin. On the other hand, when the cosmetics of Comparative Examples A-1 to A-3 that do not contain any of propolis, amino acids and heavy metal ions are used over a certain period, It can be seen that the stain removal effect and the whitening effect cannot be obtained, the skin is irritated, and the odor is felt during use.

[Embodiment of hair repair agent]
The hair restoration agent according to the present invention is characterized by containing propolis. The hair restoration agent according to the present invention preferably contains 0.5 to 15.0% by mass of an extraction solution (ethanol solution or the like) having a solid content concentration of 10% to 30%. -5.0% by mass is more preferable, and 2.0-4.0% by mass is particularly preferable (the solid content concentration is 0.05% by mass to 4.5% by mass). It is preferable to contain 0.1 to 1.5% by mass, and it is particularly preferable to contain 0.2 to 1.2% by mass). As the propolis extraction solution, it is most preferable to use an extraction solution having a solid concentration of about 20%. If the addition amount of propolis is less than the above range (if the solid content concentration is less than 0.05% by mass), it is not preferable because a sufficient effect of repairing hair damage cannot be obtained. Exceeding the above range (solid content concentration exceeding 4.5% by mass) is uneconomical and the hair feels sticky, making it difficult to clean the hair and the odor of the hair repair agent is poor. This is not preferable.

  In addition, the hair repair agent according to the present invention may contain an amino acid or a derivative thereof as necessary. Examples of amino acids or derivatives thereof include alanine, arginine, asparagine, aspartic acid, cysteine (or cystine), lysine (or lysine), glutamine, glutamic acid, and derivatives thereof such as hydrochloride and sulfate. , Cysteine, lysine, arginine, or a mixture of two or more thereof is preferable because it can efficiently impart gloss, firmness and moisture to the hair in a small amount. . In addition, when cysteine (L-cysteine), lysine (L-lysine), arginine (L-arginine), or a combination of two or more of these hydrochlorides is used, the hair is glossy and firm. It is more preferable because it can impart moisture.

  Further, when cystine is used as an amino acid, if at least a part (or all) of the cystine is the above-described improved cystine, dispersibility of cystine in the hair repair agent is improved, and “paste” on the scalp is improved. "Is preferable because it is excellent. Platinum (platinum nanocolloid) in such improved cystine exhibits a high antioxidant effect, and contributes to the effect of giving luster, firmness and moisture to the hair by interaction with propolis and cystine (or other amino acids). .

  Moreover, when using improved cystine, content of the said cystine is not specifically limited, It is preferable to make it contain 0.005-5 mass% in conversion of solid content, and make it contain 0.01-2 mass% Is more preferable. If the content of the improved cystine is less than 0.005% by mass, the effect of imparting luster, firmness and moisture to the hair becomes insufficient, which is not preferable, and the content of the improved cystine is 5% by mass. Exceeding this is not preferable because it is uneconomical and may increase irritation to the scalp.

  Further, when improved cystine is used, when the content of the cystine is adjusted within the range of 3% to 100% (weight ratio in terms of solid content) with respect to the added amount of propolis, a higher antioxidant effect is obtained. It is preferable because it exerts an effect of imparting luster, firmness and moisture to the hair by interacting with propolis, and is preferably adjusted within the range of 5% to 40%, more preferably 10% to 30%. It is particularly preferable to adjust within this range.

  Furthermore, when using improved cystine, adjusting the amount of platinum (platinum nanocolloid) added to cystine within the range of 0.01% to 1.0% (weight ratio in terms of solid content) This is preferable because the dispersibility of cystine becomes favorable, and it is more preferable to adjust in the range of 0.1% to 0.5%, and particularly preferable to adjust in the range of 0.2% to 0.3%. . In addition, when improved cystine is used, the dispersibility of cystine in the hair restoration agent can be adjusted by adjusting the content of cystine to hydrolyzed keratin within a range of 1% to 50% (weight ratio in terms of solid content). Is preferable, and it is more preferable to adjust in the range of 3% to 25%, and particularly preferable to adjust in the range of 5% to 10%. Further, when improved cystine is used, the cystine is preferably used as an aqueous solution having a solid content concentration of 1 to 5% by mass, and most preferably used as an aqueous solution having a solid content concentration of 2% by mass.

  As amino acids to be contained in the hair repair agent, acetylcysteine (N-acetyl-L-cystein), N, N′-bisacetylcystine (N, N′-diacetylcystine (N, N ′) -diacetyl-L-cystine)), N-acetyl-L-cystine, and cysteic-acid can be used. Among them, acetylcysteine is very small in quantity. It is preferable because it can efficiently impart gloss, firmness and moisture to the hair.

  The hair repair agent according to the present invention preferably contains 0.05 to 10% by mass, more preferably 0.1 to 5% by mass, of the above-described amino acid or derivative thereof as a whole. If the content of the amino acid or derivative thereof is below the above range, it is not preferable because a synergistic effect with propolis cannot be obtained, and sufficient hair damage preventing effect, gloss, firmness and moisturizing effect cannot be obtained. If the content of the amino acid or its derivative exceeds the above range, it is not preferable because it is uneconomical and may damage the hair.

  On the other hand, the addition ratio of propolis to amino acid in the hair restoration agent according to the present invention is not particularly limited, but if the addition ratio is 0.5 to 2,000%, the synergy between propolis and amino acid greatly increases. A good hair damage prevention effect, gloss, elasticity and moisturizing effect can be obtained, and it is preferably 20 to 500%, more preferably 30 to 90%.

  Furthermore, the hair restoration agent according to the present invention includes various alcohols, fermented alcohols, glycols (such as butyl glycol), extracts extracted from plants, preservatives, fragrances, viscosity modifiers, and pH adjusters as necessary. Etc. can also be added.

  Further, when fucoidan (a dietary fiber that is a kind of sulfated polysaccharide and is contained in a large amount of mucilage of brown algae such as kelp and seaweed) is added to the hair repair agent according to the present invention, hair damage can be effectively repaired. Furthermore, it is more preferable because it can efficiently impart gloss, firmness and moisture to the hair. Although the addition amount of fucoidan is not particularly limited, the hair restoration agent according to the present invention preferably contains 0.1 to 15% by mass, and more preferably 1 to 6% by mass. If the content of fucoidan is less than 0.1% by mass, synergy with propolis cannot be obtained, and sufficient hair repairing effect, gloss, firmness and moisturizing effect cannot be obtained. If the content exceeds 15% by mass, it is not preferable because it is uneconomical and the finish of the hair after treatment becomes sticky.

  In addition, a moisturizing agent (moisture adjusting agent) such as hyaluronic acid (particularly high molecular hyaluronic acid) or the like can be added to the hair restoration agent according to the present invention as necessary. In addition, when adding hyaluronic acid to the hair restoration agent according to the present invention, the addition amount is not particularly limited, but 0.005 to 5% by mass is preferable from the viewpoint of moisture retention and economical efficiency of the hair. 0.05 to 3% by mass is more preferable. In addition, when adding hyaluronic acid to the hair restoration agent according to the present invention, it is preferable to use a mixture of polymeric hyaluronic acid and sodium hyaluronate, and the mixing ratio is 30 parts by weight: 70 parts by weight. -70 weight part: It is more preferable in it being in the range of 30 weight part.

  In the production of the hair restoration agent according to the present invention, the production method is not particularly limited, but if necessary, the raw material or a mixed liquid of the raw materials is heated within a temperature range of 30 ° C to 100 ° C. It is preferable to do this.

[Example B: Example of hair restoration agent]
Hereinafter, the hair restoration agent according to the present invention will be described in more detail by way of examples. However, the hair restoration agent of the present invention is not limited to the embodiments of the examples and does not depart from the spirit of the present invention. Thus, it can be changed as appropriate. Moreover, the evaluation methods of physical properties and characteristics in the examples are as follows. In the following sensory evaluations, the average stage (◎, ○, Δ, ×) of the evaluation results for the three subjects was used as the final evaluation result.

<Repair degree of hair damage>
Select 3 subjects with large damage (damage) of hair, such as split ends, and carefully apply the hair repair agent obtained in Examples and Comparative Examples to the hair of those subjects by a predetermined amount (about 20 g). It was applied (so as to spread over the entire hair), allowed to stand for about 10 minutes, then heated at about 50 ° C. for 15 minutes and left to cool for 2 minutes. Thereafter, the hair was washed to sufficiently remove the hair repair agent and dried with a dryer. Then, the degree of restoration of the hair after drying was subjected to sensory evaluation in the following four stages by a beautician. (The final evaluation result was an intermediate value between the evaluation results of the three subjects.)
A: Hair damage (cuticle peeling, split ends, broken hair, etc.) has been repaired, and the hair has sufficient luster, firmness and moisture.
○: Damage to the hair is generally repaired, and the hair is glossy, firm and moist.
(Triangle | delta): The damage of hair is not repaired so much and gloss, firmness, and moisture are hardly seen in hair.
X: Hair damage is hardly repaired, and no gloss, firmness or moisture is seen on the hair.

<Solution uniformity>
The uniformity of the solution of the hair repair agent obtained in the examples and comparative examples was visually evaluated in the following three stages.
A: There is no precipitate at all.
○: Some precipitate is observed.
Δ: Many precipitates are observed.

[Example B-1]
<Preparation of hair restoration agent>
The hair restoration agent of Example B-1 was obtained by mixing and stirring the following components. Specifically, L-cysteine, L-lysine hydrochloride and L-arginine were mixed and stirred in purified water heated to about 80 ° C. (solution A), while propolis, glycerin and butyl glycol were mixed and stirred ( Solution B). Thereafter, the solutions A and B and fucoidan were mixed and stirred, and the mixture was reheated to about 70 ° C., then cooled to room temperature, mixed with hyaluronic acid and fragrance, and stirred, Example B -1 hair repair agent was obtained.

<Ingredients for hair restoration agent>
Amino acids L-cysteine: 0.7% by mass
L-lysine hydrochloride: 0.7% by mass
L-arginine: 0.7% by mass
Propolis (ethanol extract with a solid content of 20%): 3.0% by mass (solid content 0.6% by mass)
・ Glycerin: 50% by mass
-Butyl glycol: 20.0 mass%
・ Fucoidan: 10.0% by mass
Hyaluronic acid (a mixture of high molecular weight hyaluronic acid and sodium hyaluronate in a weight ratio of 1: 1): 2.0% by mass
-Fragrance: 0.5% by mass
・ Purified water: remaining amount

  And the repair degree of the damage of hair was evaluated by the above-mentioned method using the obtained hair restoration agent of Example B-1. The evaluation results are shown in Table 2 together with the composition of the hair repair agent.

[Examples B-2 and B-3]
The hair restoration agents of Examples B-2 and B-3 were the same as Example B-1, except that the amino acids to be added were changed to L-cysteine 0.1% by mass and 0.7% by mass, respectively. Got. And the repair degree of the damage of hair was evaluated by the method similar to Example B-1 using each obtained hair restoration agent. The evaluation results are shown in Table 2 together with the composition of the hair repair agent.

[Examples B-4 and B-5]
The hairs of Examples B-4 and B-5 were the same as Example B-1, except that the amino acids to be added were changed to L-lysine hydrochloride 0.1% by mass and 0.7% by mass, respectively. A repair agent was obtained. And the repair degree of the damage of hair was evaluated by the method similar to Example B-1 using each obtained hair restoration agent. The evaluation results are shown in Table 2 together with the composition of the hair repair agent.

[Example B-6]
A hair restoration agent of Example B-6 was obtained in the same manner as in Example B-1, except that the amino acids to be added were changed to 2.1% by mass of tryptophan. And the repair degree of the damage of hair was evaluated by the method similar to Example B-1 using the obtained hair restoration agent. The evaluation results are shown in Table 2 together with the composition of the hair repair agent.

[Examples B-7 and B-8]
The same as Example B-1 except that the addition amount of propolis was changed to 0.5 mass% (solid content 0.1 mass%) and 5.0 mass% (solid content 1.0 mass%), respectively. The hair restoration agent of Example B-7 and B-8 was obtained by the method. And the repair degree of the damage of hair was evaluated by the method similar to Example B-1 using each obtained hair restoration agent. The evaluation results are shown in Table 2 together with the composition of the hair repair agent.

[Examples B-9 and B-10]
Except having changed the addition amount of fucoidan into 2.0 mass% and 20.0 mass%, respectively, the hair restoration agent of Example B-9 and B-10 was obtained by the method similar to Example B-1. . And the repair degree of the damage of hair was evaluated by the method similar to Example B-1 using each obtained hair restoration agent. The evaluation results are shown in Table 2 together with the composition of the hair repair agent.

[Examples B-11 and B-12]
Except having changed the addition amount of hyaluronic acid into 0.1 mass% and 5.0 mass%, respectively, the hair restoration agent of Example B-11 and B-12 was obtained by the same method as Example B-1. It was. And the repair degree of the damage of hair was evaluated by the method similar to Example B-1 using each obtained hair restoration agent. The evaluation results are shown in Table 2 together with the composition of the hair repair agent.

[Example B-13]
<Preparation of hair restoration agent>
The hair restoration agent of Example B-13 was obtained by mixing and stirring the following components. That is, propolis, glycerin and butyl glycol were mixed in purified water heated to about 80 ° C. and stirred. Thereafter, the mixed solution was reheated to about 70 ° C., cooled to room temperature, mixed with a fragrance, and stirred to obtain a hair restorative of Example B-13.

<Ingredients for hair restoration agent>
Propolis (ethanol extract with a solid content of 20%): 3.0% by mass (solid content 0.6% by mass)
・ Glycerin: 50% by mass
-Butyl glycol: 20.0 mass%
-Fragrance: 0.5% by mass
・ Purified water: remaining amount

  And the repair degree of the damage of hair was evaluated by the method similar to Example B-1 using the obtained hair restoration agent of Example B-13. The evaluation results are shown in Table 2 together with the composition of the hair repair agent.

[Example B-14]
<Preparation of hair restoration agent>
The hair restoration agent of Example B-14 was obtained by mixing and stirring the following components. That is, propolis, glycerin and butyl glycol were mixed in purified water heated to about 80 ° C. and stirred. Thereafter, fucoidan is mixed and stirred in the mixed solution, reheated to about 70 ° C., cooled to room temperature, mixed with fragrance, and stirred to obtain the hair restoration agent of Example B-14. It was.

<Ingredients for hair restoration agent>
Propolis (ethanol extract with a solid content of 20%): 3.0% by mass (solid content 0.6% by mass)
・ Glycerin: 50% by mass
-Butyl glycol: 20.0 mass%
・ Fucoidan: 10.0% by mass
-Fragrance: 0.5% by mass
・ Purified water: remaining amount

  And the repair degree of the damage of hair was evaluated by the method similar to Example B-1 using the obtained hair repair agent of Example B-14. The evaluation results are shown in Table 2 together with the composition of the hair repair agent.

[Example B-15]
<Preparation of hair restoration agent>
The hair restoration agent of Example B-15 was obtained by mixing the following components.

<Ingredients for hair restoration agent>
-Aqueous solution of improved cystine (ie, cystine bound to hydrolyzed keratin by platinum) (aqueous solution having a cystine solid content concentration of 2.0%): 3.0% by mass
Amino acid L-lysine (hydrochloride): 0.1% by mass
Propolis solution (20% by mass extract (ethanol solution)): 2.0% by mass (concentration of pure components of propolis = 0.4% by mass)
・ Dispersant: 3.0% by mass
-Fragrance: 0.2% by mass
・ Glycerin: 30.0% by mass
・ Fucoidan: 3.0% by mass
・ Purified water: remaining amount

  And after using the obtained hair restoration agent of Example B-15 for a test subject by the method similar to Example B-1, it evaluated similarly to Example B-1. The evaluation results are shown in Table 2 together with the composition of the hair repair agent.

[Examples B-16 to B-18]
When preparing the hair restoration agent, the mixing ratio of the improved cystine aqueous solution was changed to 1.5% by mass, 6.0% by mass, and 9.0% by mass, respectively (ie, the pure component of the improved cystine) Example B- was prepared in the same manner as in the preparation of the hair restoration agent of Example B-15, except that the concentrations were changed to 0.03% by mass, 0.12% by mass, and 0.18% by mass, respectively. 16-B-18 hair restoration agents were prepared. And after using the hair restoration agent of those Examples B-16-B-18 to a test subject by the method similar to Example B-1, it evaluated similarly to Example B-1. The evaluation results are shown in Table 2 together with the composition of the hair repair agent.

[Example B-19]
Example B- was prepared in the same manner as in the preparation of the hair restoration agent of Example B-15, except that 0.3% by mass of acetylcysteine was mixed in place of the improved cystine aqueous solution when preparing the hair restoration agent. Nineteen hair repair agents were prepared. And after using the hair restoration agent of Example B-19 by the test subject by the method similar to Example B-1, it evaluated similarly to Example B-1. The evaluation results are shown in Table 2 together with the composition of the hair repair agent.

[Comparative Example B-1]
<Preparation of hair restoration agent>
The hair restoration agent of Comparative Example B-1 was obtained by mixing and stirring the following components at room temperature.

<Ingredients for hair restoration agent>
Hydrolyzed keratin: 20.0% by mass
・ Inosit hexaphosphoric acid: 0.2% by mass
Dipropylene glycol: 5.0% by mass
・ Pooxyethylene hydrogenated castor oil: 1.0% by mass
-Fragrance: 0.2% by mass
・ Purified water: remaining amount

  And the repair degree of the damage of hair was evaluated by the method similar to Example B-1 using the obtained hair restoration agent of Comparative Example B-1. The evaluation results are shown in Table 2 together with the composition of the hair repair agent.

[Comparative Example B-2]
<Preparation of hair restoration agent>
The hair restoration agent of Comparative Example B-2 was obtained by mixing and stirring the following components. That is, glycerin and butyl glycol were mixed in purified water heated to about 80 ° C. and stirred. Thereafter, fucoidan is mixed and stirred in the mixed solution, reheated to about 70 ° C., cooled to room temperature, mixed with fragrance, and stirred to obtain the hair restoration agent of Comparative Example B-2. It was.

<Ingredients for hair restoration agent>
・ Glycerin: 50% by mass
-Butyl glycol: 20.0 mass%
・ Fucoidan: 10.0% by mass
-Fragrance: 0.5% by mass
・ Purified water: remaining amount

  And the repair degree of the damage of hair was evaluated by the method similar to Example B-1 using the obtained hair restoration agent of comparative example B-2. The evaluation results are shown in Table 2 together with the composition of the hair repair agent.

[Comparative Example B-3]
<Preparation of hair restoration agent>
The hair restoration agent of Comparative Example B-3 was obtained by mixing and stirring the following components. That is, L-cysteine, L-lysine hydrochloride and L-arginine were mixed and stirred in purified water heated to about 80 ° C. (solution A), while glycerin and butyl glycol were mixed and stirred (solution B). ). Thereafter, the solutions A and B and fucoidan are mixed and stirred, and the mixed solution is reheated to about 70 ° C., then cooled to room temperature, mixed with fragrance, and stirred, whereby Comparative Example B-3. A hair repair agent was obtained.

<Ingredients for hair restoration agent>
Amino acids L-cysteine: 0.7% by mass
L-lysine hydrochloride: 0.7% by mass
L-arginine: 0.7% by mass
・ Glycerin: 50% by mass
-Butyl glycol: 20.0 mass%
・ Fucoidan: 10.0% by mass
-Fragrance: 0.5% by mass
・ Purified water: remaining amount

  And the repair degree of the damage of hair was evaluated by the method similar to Example B-1 using the obtained hair restoration agent of Comparative Example B-3. The evaluation results are shown in Table 2 together with the composition of the hair repair agent.

  From Table 2, the hair repair agent according to the present invention (Examples B-1 to B-19) is excellent in the repair function of hair having large damage such as split ends, and imparts gloss, firmness and moisture to the hair. I understand that I can do it. On the other hand, it turns out that the hair repair agent of Comparative Examples 1-3 which does not use propolis or the like can hardly exhibit the repair function of hair with a big damage.

[Skincare lotion embodiment]
The skin care lotion according to the present invention is characterized by containing a propolis and an amino acid. The skin care lotion according to the present invention preferably contains 0.01 to 15% by mass of an extraction solution (ethanol solution or the like) having a solid content concentration of propolis of 10% to 30%, preferably 3.0 to 10%. More preferably, it is contained (the solid content concentration is preferably 0.001% to 4.5% by mass, more preferably 0.3% to 3.0% by mass). preferable). As the propolis extraction solution, it is most preferable to use an extraction solution having a solid concentration of about 20%. When the amount of propolis added falls below the above range (when the solid content concentration falls below 0.001% by mass), sufficient wrinkle / stain removal effect, skin beautification / whitening effect, sun protection effect, dermatitis improvement effect Is not preferable, and if the amount of propolis added exceeds the above range (if the solid content concentration exceeds 4.5% by mass), it is uneconomical and the sticky feeling when applied to the skin It is not preferable because it becomes high and the odor of the lotion for skin care becomes poor.

  Further, the skin care lotion according to the present invention needs to contain an amino acid. Such amino acids include alanine, arginine, asparagine, aspartic acid, cysteine (or cystine), glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine (also referred to as lysine), methionine, phenylalanine, proline, serine, threonine. , Tryptophan, tyrosine, valine, gaba (γ-aminobutyric acid), 21 types of amino acids, L-type amino acids, or derivatives thereof such as hydrochloride, sulfate, etc. can be used, cysteine, arginine, A mixture of one or more of lysine, threonine, aspartic acid, gabba, or derivatives thereof can efficiently remove wrinkles and stains, make skin beautiful and whiten in a small amount. Effect, sun protection, dermatitis improvement It is preferable because it is possible to exert an effect. In addition, it is preferable to use a mixture of cysteine, arginine, and lysine because a very high wrinkle / stain removal effect, skin beautification / whitening effect, sun protection effect, and dermatitis improvement effect can be obtained. Moreover, as an amino acid used with propolis in the skin care lotion according to the present invention, cysteine (L-cysteine), arginine (L-arginine), lysine (L-lysine), or a hydrochloride thereof (or one of them or Use of a combination of two or more types is preferable because an extremely high wrinkle / stain removal effect, skin beautification / whitening effect, sunburn preventing effect, and dermatitis improving effect can be obtained.

  Further, when cystine is used as an amino acid, if at least a part (or all) of the cystine is the above-described improved cystine, the dispersibility of cystine in the skin care lotion is improved, and the “paste” is applied to the skin. "Is preferable because it is excellent. Platinum (platinum nanocolloid) in such improved cystine exhibits a high antioxidant effect, and by interacting with propolis and cystine (or other amino acids), the effect of removing wrinkles / stains, beautifying skin / whitening, Contributes to sunburn prevention and dermatitis improvement.

  Moreover, when using improved cystine, content of the said cystine is not specifically limited, It is preferable to make it contain 0.005-5 mass% in conversion of solid content, and make it contain 0.01-2 mass% Is more preferable. If the content of the improved cystine is less than 0.005% by mass, a sufficient wrinkle / stain removal effect, skin beautification / whitening effect, sunburn prevention effect, and dermatitis improvement effect cannot be obtained. When the content of cystine exceeds 5% by mass, it is not preferable because it is uneconomical and may cause irritation to the skin.

  Moreover, when using improved cystine, if the content of the cystine is adjusted within a range of 10% to 200% (weight ratio in terms of solid content) with respect to the added amount of propolis, a higher antioxidant effect is obtained. Demonstrating and interacting with propolis makes it possible to develop a very good wrinkle / stain removal effect, skin beautification / whitening effect, sun protection effect, and dermatitis improvement effect, preferably 20% to 100% It is more preferable to adjust within this range, and it is particularly preferable to adjust within the range of 30% to 70%.

  Furthermore, when using improved cystine, adjusting the amount of platinum (platinum nanocolloid) to cystine within the range of 0.01% to 1.0% (weight ratio in terms of solids) This is preferable because the dispersibility of cystine becomes favorable, and it is more preferable to adjust in the range of 0.1% to 0.5%, and particularly preferable to adjust in the range of 0.2% to 0.3%. . In addition, when improved cystine is used, dispersibility of cystine in a lotion for skin care can be adjusted by adjusting the content of cystine to hydrolyzed keratin within a range of 1% to 50% (weight ratio in terms of solid content). Is preferable, and it is more preferable to adjust in the range of 3% to 25%, and particularly preferable to adjust in the range of 5% to 10%. Further, when improved cystine is used, the cystine is preferably used as an aqueous solution having a solid content concentration of 1 to 5% by mass, and most preferably used as an aqueous solution having a solid content concentration of 2% by mass.

  The amino acids contained in the skin care lotion include acetylcysteine (N-acetyl-L-cystein), N, N′-bisacetylcystine (N, N′-diacetylcystine (N, N '-diacetyl-L-cystine)), N-acetyl-L-cystine, and cysteic-acid can be used. Among them, acetylcysteine is used to remove wrinkles and stains. The effect, skin beautification / whitening effect, sunburn preventing effect and dermatitis improving effect are very good, which is preferable.

  The skin care lotion according to the present invention preferably contains 0.05 to 10% by mass, more preferably 0.1 to 5% by mass of the above-mentioned amino acid (or a derivative thereof) as a whole. If the content of amino acids or derivatives thereof is below the above range, synergy with propolis cannot be obtained, and sufficient wrinkle / stain removal effect, skin beautification / whitening effect, sun protection effect, dermatitis improvement effect Since it cannot be obtained, it is not preferable. If the content of the amino acid or its derivative exceeds the above range, it is not preferable because it is not economical and may cause skin inflammation.

  On the other hand, the addition ratio of the propolis (pure component) to the amino acid in the skin care lotion according to the present invention is not particularly limited, but if the addition ratio is 0.1% or more and less than 100%, the synergistic action of the propolis and the amino acid The higher wrinkle / stain removal effect, skin beautification / whitening effect, sunburn prevention effect, and dermatitis improvement effect are preferable, and 3% to 30% is more preferable, and 5% to 20% is preferable. Particularly preferred.

  Furthermore, it is preferable to add a plant extract to the skin care lotion according to the present invention for the purpose of moisturizing, antibacterial, blood circulation promotion and anti-corruption. As the plant extract, various types can be used, but it is preferable to use a clara leaf extract, a ginger root extract (a ginger extract), a senkyu extract, a ginger extract (a ginger root extract), or a ginseng root extract. In particular, when Clara leaf extract is added, in addition to the effects of moisturizing, blood circulation promotion, antibacterial, antioxidant, skin astringency, antipruritic, etc., effects such as whitening, sunburn prevention, and skin repair after sunburn are also obtained. Therefore, the addition of ginger root extract is preferable because it can provide effects such as blood circulation promotion, antibacterial, antioxidant, antipruritic and the like, and the addition of senkyu extract provides effects such as anti-inflammatory, sedation, blood circulation promotion, etc. Preferably, the addition of Toki extract is preferable because it can be expected to have a whitening effect and an antitumor effect in addition to the effects of moisturizing, peripheral vasodilation, blood circulation promotion, anti-inflammatory, anti-allergy, tonic, analgesia, etc. Addition of peach leaf extract is preferable because it provides effects such as moisturizing, antibacterial, antioxidant, anti-inflammatory, skin convergence, and alleviation of irritation. Addition of ginseng root extract promotes metabolism. Preferred other operational effects such as blood circulation, anti-wrinkle, so also obtained effects such as skin roughness preventing.

  In addition, the above-mentioned plant extracts can be used alone, but when used in a mixture of two or more, the moisturizing, antibacterial, blood circulation promotion, Since it becomes possible to express effects, such as prevention of corruption, it is preferable. In addition, although the addition amount of a plant extract is not specifically limited, It is preferable to add 0.1-5 mass% in total of solid content, and it is more preferable to add 0.5-3 mass%. If the added amount of the plant extract is less than 0.1% by mass, it is not preferable because sufficient moisturizing, antibacterial, blood circulation promotion, anti-corrosion effect, etc. cannot be obtained, and conversely, the added amount of the plant extract exceeds 5% by mass. This is not preferable because it is not economical and the appearance and odor of the skin care lotion may be poor.

  Further, the skin care lotion according to the present invention includes, in addition to propolis and amino acids, which are essential components, components commonly used in skin care lotions, such as oily components, synthetic or natural product surfactants, moisturizers. Preservatives (antibacterial / bactericidal agents), powder components, ultraviolet absorbers, antioxidants, pigments, fragrances and the like can be appropriately blended as necessary. In addition, various alcohols, fermented alcohols, glycols (such as butyl glycol), thickeners (viscosity modifiers), pH adjusters, etc. may be added to the skin care lotion according to the present invention as necessary. Is also possible.

  The oily component, surfactant, emulsifier and emulsifying aid, moisturizer, thickener, antiseptic / bactericidal agent, powder component, ultraviolet absorber, and antioxidant are included in the cosmetic according to the present invention described above. The same ones that can be used can be used.

  Furthermore, a moisturizing agent (moisture adjusting agent) such as hyaluronic acid (particularly high-molecular hyaluronic acid) or the like can be added to the skin care lotion according to the present invention as necessary. In addition, when adding hyaluronic acid, the addition amount is not particularly limited, but 0.005 to 5% by mass is preferable from the viewpoint of skin moisture retention and economy, and 0.05 to 3% by mass. Is more preferable. In addition, when adding hyaluronic acid, it is preferable to use a mixture of polymeric hyaluronic acid and sodium hyaluronate, and the mixing ratio is 30 parts by weight: 70 parts by weight to 70 parts by weight: 30 parts by weight. It is more preferable that it is within the range.

  In addition, fucoidan (a dietary fiber and seaweed extract, which is a kind of sulfated polysaccharide, and is abundant in brown algae mucilage such as kelp and seaweed) is added to the skin care lotion according to the present invention. It is preferable because the stain removing action, skin beautification / whitening action, sunburn preventing effect, and dermatitis improving effect are further improved. The amount of fucoidan added is not particularly limited, but it is preferably 0.005 to 5% by mass from the viewpoints of wrinkle / smear removing action, skin beautification / whitening action, sunburn preventing effect, dermatitis improving effect and economic efficiency. 0.05 to 2% by mass is more preferable.

  Furthermore, the skin care lotion according to the present invention preferably contains heavy metal ions as an antibacterial component. As such heavy metal ions, various types of ions can be used. Silver ions, zinc ions, titanium ions, or one of them, or a mixture of two or more thereof can be highly wrinkled. This is preferable because it is effective in removing stains, making skin beautiful and whitening, preventing sunburn, and improving dermatitis. In addition, it is more preferable to use a composite metal ion of silver ion, zinc ion and titanium ion because the wrinkle / stain removal effect, skin beautification / whitening effect, sun protection effect and dermatitis improvement effect will be even better. . The content of heavy metal ions is not particularly limited, but is preferably 0.1 to 10% by mass, and more preferably 0.5 to 5% by mass. If the content of heavy metal ions is below the above range, it is not preferable because sufficient wrinkle / stain removal effect, skin beautification / whitening effect, sun protection effect, dermatitis improvement effect cannot be obtained, and content of heavy metal ions However, if it exceeds the above range, it is not preferable because it is uneconomical and may induce skin irritation.

  In the production of the skin care lotion according to the present invention, the production method is not particularly limited, but if necessary, the raw material or a mixed liquid of the raw materials is heated within a temperature range of 30 ° C to 100 ° C. It is preferable to do this.

[Example C: Example of lotion for skin care]
Hereinafter, the skin care lotion according to the present invention will be described in more detail by way of examples. However, the skin care lotion of the present invention is not limited to the embodiments of the examples, and does not depart from the spirit of the present invention. Thus, it can be changed as appropriate. Moreover, the evaluation methods of physical properties and characteristics in the examples are as follows. In the following sensory evaluation, the average stage (◯, Δ, ×) of the evaluation results for the three subjects was used as the final evaluation result.

<Wrinkle removal and stain removal effect>
The skin care lotion prepared in each example and comparative example was used for 3 subjects (all in their 50s) by the following methods (1) to (4), and the use was performed for a certain period (1 week). It repeated over.
(1) Applying a predetermined amount (about 5.0g) of skin care lotion to the face (application by hand)
(2) Sufficient rubbing into skin (3) Holding for about 10 hours (4) Removal by prior application using commercially available soap And the face of each subject after repeated use of skin care lotion as described above The skin condition of was subjected to sensory evaluation in the following four stages.
○: A sufficient reduction effect is observed in the corners of the eyes, wrinkles on the forehead and skin spots.
Δ: Slight reduction effect is observed in the corners of the eyes, wrinkles of the forehead and skin spots.
×: Almost alleviating effect is not seen in the corners of the eyes, wrinkles of the forehead and skin spots

<Whitening effect>
Changes in skin color on the face of each subject after repeating the use of the skin care lotion prepared in each Example and Comparative Example (use by the method of (1) to (4) above) over a certain period of time The sensory evaluation was performed in the following four stages.
○: Sufficient whitening is observed on the skin of the entire face.
(Triangle | delta): Slight whitening is recognized by the skin of the whole face.
X: Whitening is not recognized in the skin of the whole face.

<Anti-sun effect>
The skin care lotion prepared in each example and comparative example was applied to a part of the face (one side cheek) by a predetermined amount (about 0.04 g / cm ² ), and then for a predetermined time (about 5 hours). Then, the face was exposed to sunlight, and then the part where the skin care lotion was applied and the part where the skin care lotion was not applied were visually observed, and the tanned state was subjected to sensory evaluation in the following three stages.
○: A clear difference (color difference) was observed between the tanned state of the application part of the skin care lotion and the tanned state of the non-application part.
(Triangle | delta): Some difference was looked at by the sunburn state of the application part of the lotion for skin care, and the sunburn state of the non-application part.
X: No difference was found between the tanned state of the application part of the skin care lotion and the tanned state of the non-application part.

<Improvement effect of dermatitis>
The skin care lotion prepared in each example and comparative example was used repeatedly over a period of time for investigators with atopic dermatitis disease (inflammation twice a day for approximately one week). It was applied enough to the intense part). Thereafter, sensory evaluation of the improved state of atopic dermatitis was visually performed in the following four stages.
○: Significant improvement effect was observed in the symptoms of the affected area.
(Triangle | delta): Some improvement effect was seen by the symptom of the affected part.
X: The improvement effect was not seen in the symptom of the affected part.

<Odor of skincare lotion>
The odor felt by the subject when the use of the skin care lotion as described above was repeated over a certain period of time was sensory evaluated in the following three stages.
○: No particular bad odor is felt.
Δ: A slight odor is felt.
X: A bad smell is felt.

<Solution uniformity>
The uniformity of the compositions of the skin care lotions obtained in the examples and comparative examples was visually evaluated in the following three stages.
A: High uniformity.
○: Slightly separated substances are observed.
Δ: Many separated substances are observed.

[Example C-1]
<Preparation of skin care lotion>
The skin care lotion of Example C-1 was obtained by mixing the following components. In other words, amino acids (L-cysteine (hydrochloride), L-arginine, L-lysine (hydrochloride)) are mixed and stirred in purified water heated to about 80 ° C. (solution A), propolis, butyl glycol The glycerin was mixed and stirred (solution B). Thereafter, the solutions A and B, the plant extract and fucoidan are mixed and stirred, and the mixture is reheated to about 70 ° C., then cooled to room temperature, and hyaluronic acid, a fragrance, and a preservative are mixed and stirred. Thus, a skin care lotion of Example C-1 was obtained.
<Ingredients for skin care lotion>
Propolis solution (20% by mass extract (ethanol solution)): 1.0% by mass (concentration of pure components of propolis = 0.2% by mass)
・ Butyl glycol: 5.0% by mass
・ Glycerin: 79.8% by mass
-Fragrance: 0.2% by mass
-Fucoidan (seaweed extract): 3.0% by mass
・ Plant extract (1.0% by mass)
・ Clara leaf extract: 0.2% by mass
・ Ginger root extract: 0.2% by mass
-Senkyu extract: 0.2% by mass
・ Touki extract: 0.2% by mass
・ Ginseng root extract: 0.2% by mass
・ Amino acid (2.1% by mass)
L-cysteine (hydrochloride): 0.7% by mass
L-arginine: 0.7% by mass
L-lysine (hydrochloride): 0.7% by mass
Hyaluronic acid (a mixture of high-molecular hyaluronic acid and sodium hyaluronate in a weight ratio of 1: 1): 3.0% by mass
・ Preservative (0.1% by mass)
・ Methylparaben: 0.025% by mass
・ Ethylparaben: 0.025% by mass
・ Propylparaben: 0.025% by mass
・ Butylparaben: 0.025 mass%
・ Purified water: remaining amount

  After that, using the skin care lotion for the three subjects by the above method, the above-mentioned “wrinkle removal / smear removal effect”, “whitening effect”, “sunburn prevention effect”, “dermatitis improvement effect” And four items of “smelling skin care lotion” were evaluated. The evaluation results are shown in Table 3 together with the composition of the skin care lotion.

[Examples C-2 to C-4]
When preparing a skin care lotion, the amino acids to be added are L-cysteine only, L-arginine only, and L-lysine (hydrochloride), respectively, and the mixing ratio thereof is changed to 3.0% by mass. The skin care lotions of Examples C-2 to C-4 were prepared in the same manner as in the preparation of the skin care lotion of Example C-1, except that the amount of the remaining purified water was changed according to the change. Prepared. And after using those skin care lotions of Examples C-2 to C-4 in the same manner as in Example C-1, they were evaluated in the same manner as in Example C-1. The evaluation results are shown in Table 3 together with the composition of the skin care lotion.

[Examples C-5 to C-8]
When preparing a lotion for skin care, the mixing ratio of propolis (concentration of pure components of propolis) was changed to 0.025 mass%, 0.25 mass%, 0.5 mass%, and 2.5 mass%, respectively. (That is, the concentration of the pure component of propolis was changed to 0.005% by mass, 0.05% by mass, 0.1% by mass, and 0.5% by mass, respectively, and the remaining purified water was adjusted accordingly. The skin care lotions of Examples C-5 to C-8 were prepared in the same manner as the preparation of the skin care lotion of Example C-1. And after using the lotion for skin care of those Examples C-5 to C-8 to a subject by the method similar to Example C-1, it evaluated similarly to Example C-1. The evaluation results are shown in Table 3 together with the composition of the skin care lotion.

[Examples C-9 to C-11]
When the skin care lotion was prepared, the plant extract, hyaluronic acid and fucoidan were not added (the amount of the remaining purified water was increased by those amounts), respectively. In the same manner as in the preparation, skin care lotions of Examples C-9 to C-11 were prepared. And after using these skin care lotions of Examples C-9 to C-11 on subjects in the same manner as in Example C-1, they were evaluated in the same manner as in Example C-1. The evaluation results are shown in Table 3 together with the composition of the skin care lotion.

[Example C-12]
<Preparation of skin care lotion>
A skin care lotion of Example C-12 was obtained by mixing the following components.

<Ingredients for skin care lotion>
Propolis solution (20% by mass extract (ethanol solution)): 1.0% by mass (concentration of pure components of propolis = 0.2% by mass)
-Fragrance: 0.1% by mass
・ Dispersant: 1.5% by mass
Amino acid L-arginine: 0.1% by mass
L-lysine (hydrochloride): 0.1% by mass
-Aqueous solution of improved cystine (ie, cystine bound to hydrolyzed keratin by platinum) (aqueous solution having a cystine solid content concentration of 2.0%): 5.0% by mass
・ Sodium hyaluronate: 10.0% by mass
Absorbing hyaluronic acid (hydroxypropyltrimonium hyaluronate): 3.0% by mass
-Fucoidan: 20.0 mass%
・ Glycerin: 30.0% by mass
-Preservative (ethoxydiglycol, phenoxyethanol, methylparaben, propylparaben, butylparaben, ethylparaben mixed solution): 0.1% by mass
・ Kitasan gum: 0.1% by mass
・ Purified water: remaining amount

  The obtained skin care lotion of Example C-12 was evaluated in the same manner as in Example C-1 after being used for the subject in the same manner as in Example C-1. The evaluation results are shown in Table 3 together with the composition of the skin care lotion.

[Embodiments C-13 to C-15]
When preparing the skin care lotion, the mixing ratio of the improved cystine aqueous solution was changed to 3.0% by mass, 7.0% by mass, and 10.0% by mass, respectively (ie, the pure component of the improved cystine) Example C- was prepared in the same manner as in the preparation of the skin care lotion of Example C-12, except that the concentrations were changed to 0.06% by mass, 0.14% by mass, and 0.2% by mass, respectively. 13-C-15 skin care lotions were prepared. And after using the lotion for skin care of those Examples C-13-C-15 to a test subject by the method similar to Example C-1, it evaluated similarly to Example C-1. The evaluation results are shown in Table 3 together with the composition of the skin care lotion.

[Example C-16]
Example C- was prepared in the same manner as in the preparation of the skin care lotion of Example C-12, except that 0.3% by mass of acetylcysteine was mixed in place of the improved cystine aqueous solution when preparing the skin care lotion. Sixteen skin care lotions were prepared. Then, the skin care lotion of Example C-16 was evaluated in the same manner as in Example C-1 after being used for the subject in the same manner as in Example C-1. The evaluation results are shown in Table 3 together with the composition of the skin care lotion.

<Comparative Example C-1>
When preparing the skin care lotion, comparison was made in the same manner as the preparation of the skin care lotion of Example C-1, except that no propolis was added (the amount of the remaining purified water was increased by that amount). The skin care lotion of Example C-1 was prepared. And after using the skin care lotion of the comparative example C-1 to a test subject by the method similar to Example C-1, it evaluated similarly to Example C-1. The evaluation results are shown in Table 3 together with the composition of the skin care lotion.

<Comparative Example C-2>
When preparing a skin care lotion, a comparison was made in the same manner as in the preparation of the skin care lotion of Example C-1, except that no amino acid was added (the amount of the remaining purified water was increased by that amount). The skin care lotion of Example C-2 was prepared. And after using the lotion for skin care of the comparative example C-2 to a test subject by the method similar to Example C-1, it evaluated similarly to Example C-1. The evaluation results are shown in Table 3 together with the composition of the skin care lotion.

  From Table 3, when the skin care lotions of Examples C-1 to C-11 containing propolis and amino acids were used for the subjects, both the wrinkle removing / bleaching effect and the whitening effect were good, the sun protection effect and the skin It is effective in improving the flames, and it can be seen that the odor of the skin care lotion is not a concern when used. In addition, when the skin care lotion of Examples C-12 to C-16 containing propolis and improved cystine (or acetylcysteine) was used for the test subject, both the wrinkle removal / scratch removal effect and the whitening effect were extremely good. It has an effect of preventing sunburn and improving dermatitis. Moreover, it can be seen that the odor of the lotion for skin care is not a concern during use. On the other hand, when using the skin care lotion of Comparative Examples C-1 and C-2 containing no propolis or amino acids, good wrinkle removal / smear removal effect, whitening effect cannot be obtained, It can be seen that an effect of preventing sunburn or improving dermatitis is desired.

[Embodiment of hair restorer]
The hair restorer according to the present invention is characterized by containing a propolis and an amino acid. The hair restorer according to the present invention preferably contains 0.01 to 15% by mass of an extraction solution (ethanol solution or the like) having a solid content concentration of propolis of 10% to 30%, preferably 3.0 to 10% by mass. It is more preferable to contain (So, as solid content concentration, it is preferable to contain 0.001 mass%-4.5 mass%, and it is more preferable to contain 0.3 mass%-3.0 mass%) . As the propolis extraction solution, it is most preferable to use an extraction solution having a solid concentration of about 20%. If the amount of propolis added is less than the above range (the solid content concentration is less than 0.001% by mass), a sufficient hair growth effect (hair growth effect, hair nourishing effect) cannot be obtained. If the amount added exceeds the above range (if the solid content concentration exceeds 4.5% by mass), it is uneconomical and the feeling of stickiness when applied to the skin is high, and the odor of the hair restorer is poor. This is not preferable.

  Further, the hair restorer according to the present invention needs to contain an amino acid. Such amino acids include alanine, arginine, asparagine, aspartic acid, cysteine (or cystine), glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine (also referred to as lysine), methionine, phenylalanine, proline, serine, threonine. , Tryptophan, tyrosine, valine, GABA (γ-aminobutyric acid), 21 types of amino acids, L-type amino acids, or derivatives thereof such as hydrochloride, sulfate, etc. can be used. Arginine, cysteine ( Or cystine), lysine, threonine, aspartic acid, gabba, or a mixture of two or more of these derivatives, a good hair growth effect (hair growth effect, (Hair nourishing effect) Arbitrariness. In addition, it is preferable to use a mixture of cysteine, arginine, and lysine because a very high hair-growth effect (hair growth effect, hair-growth effect) can be obtained. Moreover, as an amino acid used with the propolis in the hair restorer which concerns on this invention, cysteine (L-cysteine), arginine (L-arginine), lysine (L-lysine), or those hydrochlorides (or one or two of them) Use of a combination of at least species is preferable because extremely high hair-growth effects (hair growth effect, hair nourishing effect) can be obtained.

  Further, when cystine is used as an amino acid, if at least a part (or all) of the cystine is the above-described improved cystine, dispersibility of cystine in the hair restorer is improved, and “paste” on the scalp is achieved. Is preferable because it becomes favorable. Platinum (platinum nanocolloid) in such improved cystine exhibits a high antioxidant effect, and contributes to the hair-growth effect by interaction with propolis and cystine (or other amino acids).

  Moreover, when using improved cystine, content of the said cystine is not specifically limited, It is preferable to make it contain 0.005-5 mass% in conversion of solid content, and make it contain 0.01-2 mass% Is more preferable. When the content of the improved cystine is less than 0.005% by mass, a sufficient hair-growth effect cannot be obtained, which is not preferable. When the content of the improved cystine exceeds 5% by mass, it is uneconomical. Since there is a possibility that the stimulation to the scalp may be strengthened, it is not preferable.

  Moreover, when using improved cystine, if the content of the cystine is adjusted within a range of 10% to 200% (weight ratio in terms of solid content) with respect to the added amount of propolis, a higher antioxidant effect is obtained. Demonstrating and interacting with propolis provides a very good hair damage prevention effect, which is preferable when adjusted within the range of 30% to 170%, more preferably within the range of 50% to 140%. Particularly preferred.

  Furthermore, in the case of using improved cystine, if the amount of platinum (platinum nanocolloid) added to cystine is adjusted within the range of 0.01% to 1.0% (weight ratio in terms of solid content), Therefore, the dispersibility of cystine is preferable, and it is more preferable to adjust within the range of 0.1% to 0.5%, and particularly preferable to adjust within the range of 0.2% to 0.3%. In addition, when improved cystine is used, the dispersibility of cystine in the hair restorer can be improved by adjusting the content of cystine to hydrolyzed keratin within the range of 1% to 50% (weight ratio in terms of solid content). Since it becomes favorable, it is preferable to adjust within the range of 3% to 25%, more preferable to adjust within the range of 5% to 10%. Further, when improved cystine is used, the cystine is preferably used as an aqueous solution having a solid content concentration of 1 to 5% by mass, and most preferably used as an aqueous solution having a solid content concentration of 2% by mass.

  As amino acids to be contained in the hair restorer, acetylcysteine (N-acetyl-L-cystein), N, N'-bisacetylcystine (N, N'-diacetylcystine (N, N'-) diacetyl-L-cystine)), N-acetyl-L-cystine, and cysteic-acid can be used. Among them, acetylcysteine is very efficient in a small amount. Therefore, it is preferable because the hair growth effect can be expressed.

  The hair restorer according to the present invention preferably contains 0.05 to 10% by mass, and more preferably 0.1 to 5% by mass of the above-mentioned amino acid (or a derivative thereof) as a whole. If the content of the amino acid or its derivative is below the above range, synergism with propolis cannot be obtained, and sufficient hair growth effects (hair growth effect, hair nourishing effect) cannot be obtained. If the content of the derivative exceeds the above-mentioned range, it is not preferable because it is not economical and may cause irritation to the skin.

  On the other hand, the addition ratio of the propolis (pure component) to the amino acid in the hair restorer according to the present invention is not particularly limited, but if the addition ratio is 0.1% or more and less than 100%, the synergy between the propolis and the amino acid A higher hair-growth effect (hair growth effect, hair-restoration effect) is obtained, preferably 5% to 50%, more preferably 10% to 30%.

  In addition to the essential ingredients propolis and amino acids, the hair restorer according to the present invention includes components usually used in hair restorers, such as oily components, synthetic or natural surfactants, moisturizers, A sticking agent, antiseptic / bactericidal agent, powder component, ultraviolet absorber, antioxidant, pigment, fragrance and the like can be appropriately blended as necessary. In addition, for the hair restorer according to the present invention, various alcohols, fermented alcohols, glycols (such as butyl glycol), extracts extracted from plants, preservatives, fragrances, viscosity modifiers, pH adjusters, as necessary. Etc. can also be added.

  The oily component, surfactant, emulsifier and emulsification aid, moisturizer, thickener, antiseptic / disinfectant, powder component, ultraviolet absorber, antioxidant, The same ones that can be used for skin care lotions can be used.

  Furthermore, it is possible to add a moisturizing agent (moisture adjusting agent) such as hyaluronic acid (particularly absorption hyaluronic acid, for example, hydroxypropyltrimonium hyaluronate) to the hair restorer according to the present invention, if necessary. It is. In addition, when adding hyaluronic acid to the hair restorer according to the present invention, the addition amount is not particularly limited, but 0.005 to 5% by mass is preferable from the viewpoint of moisture retention and economical efficiency of the skin, It is more preferable in it being 0.05-2 mass%.

  In addition, it is preferable to add fucoidan to the hair-restoring agent according to the present invention because the hair-restoring effect (hair growth effect, hair-restoring effect) is further improved by antibacterial action. Although the addition amount of fucoidan is not particularly limited, it is preferably 0.005 to 5% by mass from the viewpoint of hair growth action (hair growth action, hair nourishing action) and economy, and is 0.05 to 2% by mass. And more preferred.

  In the production of the hair restorer according to the present invention, the production method is not particularly limited, but the raw material or a mixed liquid of the raw materials is heated within a temperature range of 30 ° C to 100 ° C as necessary. Is preferred.

[Example D: Example of hair restorer]
Hereinafter, the hair restorer according to the present invention will be described in more detail by way of examples.However, the hair restorer of the present invention is not limited to the embodiments of the examples, and does not depart from the spirit of the present invention. It can be changed as appropriate. Moreover, the evaluation methods of physical properties and characteristics in the examples are as follows. In the following sensory evaluations, the average stage (◎, ○, Δ, ×) of the evaluation results for the three subjects was used as the final evaluation result.

<Hair restoration effect>
The hair restorer prepared in each Example and Comparative Example was used for 3 subjects (all men in their 50s) by the following methods (1) to (4), and the use was performed for a certain period (1 week). It repeated over.
(1) After washing and drying the hair, apply a predetermined amount (about 5.0 g) of hair growth agent to the scalp (by hand)
(2) Sufficient rubbing of the hair preparation into the scalp (3) Holding for about 24 hours And, after repeating the use of the hair restorer as described above, the condition of each subject's hair is sensory evaluated in the following three stages did.
○: Hair loss decreased and hair increased.
Δ: Hair loss slightly decreased and hair increased slightly.
X: Reduction in hair loss and increase in hair cannot be recognized.

<Skin irritation>
When the use of the hair-restoring agent as described above was repeated over a certain period, the skin irritation of each subject was subjected to sensory evaluation in the following four stages.
○: No irritation to the scalp.
Δ: Slight irritation is felt.
X: A strong stimulus is felt.

<Odor of hair restorer>
The odor felt by the subject when the use of the hair restorer as described above was repeated over a certain period of time was sensory-evaluated in the following three stages.
○: No particular bad odor is felt.
Δ: A slight odor is felt.
X: A bad smell is felt.

<Solution uniformity>
The uniformity of the hair restorer solution obtained in the examples and comparative examples was sensory-evaluated by the following three stages by visual observation.
A: There is no precipitate at all.
○: Some precipitate is observed.
Δ: Many precipitates are observed.

[Example D-1]
<Preparation of hair restorer>
The hair growth agent of Example D-1 was obtained by mixing the following components.

<Ingredients for hair restorer>
Propolis solution (20% by mass extract (ethanol solution)): 0.25% by mass (concentration of pure components of propolis = 0.05% by mass)
-Fragrance: 0.05% by mass
・ Dispersant: 0.5% by mass
-Aqueous solution of improved cystine (ie, cystine bound to hydrolyzed keratin by platinum) (aqueous solution having a cystine solid content concentration of 2.0%): 3.0% by mass
Amino acid L-arginine: 0.1% by mass
L-lysine (hydrochloride): 0.1% by mass
-Sodium hyaluronate: 5.0% by mass
Absorption type hyaluronic acid (hydroxypropyltrimonium hyaluronate): 1.5% by mass
・ Fucoidan: 2.5% by mass
・ Glycerin: 2.5% by mass
-Antiseptic (mixed solution of ethoxydiglycol, phenoxyethanol, methylparaben, propylparaben, butylparaben, ethylparaben): 0.3% by mass
・ Purified water: remaining amount

  After that, the above-mentioned method is used for three subjects with a hair restoration agent for a certain period (one week), and the above three items of “hair restoration effect”, “stimulation to skin” and “scent of hair restoration agent”. Was evaluated. The evaluation results are shown in Table 4 together with the composition of the hair restorer.

[Examples D-2 to D-4]
When preparing the hair restorer, the mixing ratio of the improved cystine aqueous solution was changed to 1.0% by mass, 2.0% by mass, and 4.0% by mass, respectively (ie, the pure component of the improved cystine Except for changing the concentrations to 0.02% by mass, 0.04% by mass, and 0.08% by mass, respectively) A hair restorer of D-4 was prepared. And after using the hair restorer of those Examples D-2 to D-4 to a test subject by the method similar to Example D-1, it evaluated similarly to Example D-1. The evaluation results are shown in Table 4 together with the composition of the hair restorer.

[Example D-5]
The hair restoration of Example D-5 was carried out in the same manner as in the preparation of the hair restoration agent of Example D-1, except that 0.05% by mass of cysteine was mixed instead of the improved cystine aqueous solution when preparing the hair restoration agent. An agent was prepared. And after using the hair restorer of the Example D-5 to a test subject by the method similar to Example D-1, it evaluated similarly to Example D-1. The evaluation results are shown in Table 4 together with the composition of the hair restorer.

[Example D-6]
When preparing the hair restorer, the same procedure as in Example D-6 was repeated except that 0.1% by mass of acetylcysteine was mixed instead of the aqueous solution of improved cystine. A hair restorer was prepared. And after using the hair restorer of the example D-6 to a test subject by the method similar to Example D-1, it evaluated similarly to Example D-1. The evaluation results are shown in Table 4 together with the composition of the hair restorer.

<Comparative Example D-1>
When preparing the hair restorer, the hair restorer of Comparative Example D-1 was prepared in the same manner as the preparation of the hair restorer of Example D-1, except that no propolis was added. And after using the hair restorer of the comparative example D-1 to a test subject by the method similar to Example D-1, it evaluated similarly to Example D-1. The evaluation results are shown in Table 4 together with the composition of the hair restorer.

<Comparative Example D-2>
When preparing the hair restorer, a hair restorer of Comparative Example D-3 was prepared in the same manner as the preparation of the hair restorer of Example D-1, except that no amino acid was added. And after using the hair restorer of the comparative example D-3 to a test subject by the method similar to Example D-1, it evaluated similarly to Example D-1. The evaluation results are shown in Table 4 together with the composition of the hair restorer.

  From Table 4, when the hair restorer of Examples D-1 to D-6 containing propolis and amino acids (improved cystine, cysteine, acetylcysteine) is used for a subject over a certain period, the hair restorer effect is good. Therefore, it can be seen that there is little irritation to the skin and the odor of the hair restorer is not anxious at the time of use. On the other hand, when the hair restorer of Comparative Examples 1 and 2 that does not contain any of propolis and amino acids is used for a certain period of time, a good hair restorer effect cannot be obtained, It can be seen that there is an irritating or bad smell when used.

[Embodiments of permanent liquid and hair conditioner]
Hereinafter, embodiments of the permanent solution and the hair conditioner according to the present invention will be described in detail. The permanent liquid and the hair conditioner according to the present invention are characterized by containing propolis and improved cystine or acetylcysteine. The perm solution according to the present invention preferably contains 0.01 to 15% by mass of an extraction solution (ethanol solution or the like) having a solid content concentration of 10% to 30%, and 3.0 to 10% by mass. (Thus, the solid content concentration is preferably 0.001% to 4.5% by mass, more preferably 0.3% to 3.0% by mass. ). As the propolis extraction solution, it is most preferable to use an extraction solution having a solid concentration of about 20%. If the added amount of propolis is below the above range (solid content concentration is less than 0.001% by mass), it is not preferable because sufficient hair damage preventing effect, gloss, firmness and moisturizing effect cannot be obtained. If the added amount of propolis exceeds the above range (the solid content concentration exceeds 4.5% by mass), it is uneconomical and the feeling of stickiness of the hair becomes high, making it difficult to clean the hair. This is not preferable because the odor of the perm liquid becomes poor.

  Moreover, it is preferable to contain 0.01-10 mass% of extraction solutions whose solid content concentration of propolis is 10%-30% in the permanent liquid and hair conditioner which concern on this invention, and 1.0-5 More preferably, it is contained (the solid content concentration is preferably 0.001% to 3.0% by mass, more preferably 0.1% to 1.5% by mass). preferable). As the propolis extraction solution, it is most preferable to use an extraction solution (such as an ethanol solution) having a solid concentration of about 20%. If the added amount of propolis is below the above range (solid content concentration is less than 0.001% by mass), it is not preferable because sufficient hair damage preventing effect, gloss, firmness and moisturizing effect cannot be obtained. If the added amount of propolis exceeds the above range (the solid content concentration exceeds 3.0% by mass), it is uneconomical and the feeling of stickiness of the hair becomes high, making it difficult to clean the hair. It is not preferable.

  In addition, the permanent liquid and the hair conditioner according to the present invention may contain an amino acid other than improved cystine or a derivative thereof as necessary. Examples of amino acids or derivatives thereof include alanine, arginine, asparagine, aspartic acid, cysteine (or cystine), glutamine, glutamic acid, or derivatives thereof such as hydrochloride, sulfate, and the like. Arginine, cysteine, lysine (Or lysine), threonine, tryptophan, or a mixture of two or more of them can efficiently impart luster, firmness and moisture to the hair in a small amount. Therefore, it is preferable. In addition, it is more preferable to use a mixture of threonine, cysteine, and arginine because gloss, elasticity and moisture can be imparted to the hair very efficiently. In addition, cysteine (L-cysteine), arginine (L-arginine), or a hydrochloride thereof (or one or a combination of two or more thereof) is used as an amino acid to be used with propolis in the perm solution according to the present invention. When used, it is more preferable because it can impart gloss, firmness and moisture to the hair very efficiently.

  Furthermore, it is preferable to use improved cystine together with propolis because the dispersibility of cystine in the perm solution or hair conditioner is improved and the “paste” on the scalp is improved. Platinum (platinum nanocolloid) in the improved cystine exhibits a high antioxidant effect, and contributes to the effect of preventing damage to hair by interacting with propolis and cystine (or other amino acids).

  Moreover, although content of improved cystine is not specifically limited, It is preferable to contain 0.005-5 mass% in conversion of solid content, and it is more preferable to contain 0.01-2 mass%. If the content of the improved cystine is less than 0.005% by mass, it is not preferable because a sufficient effect of preventing damage to the hair cannot be obtained. If the content of the improved cystine exceeds 5% by mass, it is uneconomical. In addition, there is a possibility that the scalp may be strongly stimulated, which is not preferable.

  In addition, when the content of improved cystine is adjusted within the range of 0.5% to 50% (weight ratio in terms of solid content) with respect to the added amount of propolis, it exhibits a higher antioxidant effect, Since the effect of preventing damage to hair is very good due to the interaction, it is preferable to adjust within the range of 1% to 30%, and more preferable to adjust within the range of 3% to 10%.

  Furthermore, when the amount of platinum (platinum nanocolloid) added to the improved cystine is adjusted within the range of 0.01% to 1.0% (weight ratio in terms of solid content), cystine in the permanent liquid or hair conditioner Therefore, it is more preferable to adjust within the range of 0.1% to 0.5%, and particularly preferable to adjust within the range of 0.2% to 0.3%. In addition, when the content of improved cystine with respect to hydrolyzed keratin is adjusted within the range of 1% to 50% (weight ratio in terms of solid content), dispersibility of cystine in the perm solution or hair conditioner is good. Therefore, it is preferable to adjust within the range of 3% to 25%, and more preferable to adjust within the range of 5% to 10%. Further, the improved cystine is preferably used as an aqueous solution having a solid content concentration of 1 to 5% by mass, and most preferably used as an aqueous solution having a solid content concentration of 2% by mass.

  In addition, as an amino acid to be contained in the perm solution or hair conditioning agent together with (or instead of) the improved cystine, acetylcysteine (N-acetyl-L-cystein), N, N ′ -Use bisacetylcystine (N, N'-diacetyl-L-cystine), N-acetyl-L-cystine, cysteic-acid Among them, it is preferable to use acetylcysteine because it can impart gloss, firmness and moisture to hair very efficiently with a small amount.

  The permanent liquid according to the present invention preferably contains 0.05 to 10% by mass, more preferably 0.1 to 5% by mass of the above-mentioned amino acid or derivative thereof as a whole. If the content of the amino acid or its derivative is below the above range, synergy with propolis cannot be obtained, and it is not preferable because sufficient hair damage prevention effect, gloss, firmness and moisturizing effect cannot be obtained, If the content of the amino acid or derivative thereof exceeds the above range, it is not preferable because it is uneconomical and may damage hair.

  Moreover, it is preferable to contain 0.3-15 mass% of the above-mentioned amino acid or its derivative (s) in the hair conditioner which concerns on this invention, and it is more preferable to contain 0.5-7 mass%. If the content of the amino acid or its derivative is below the above range, synergy with propolis cannot be obtained, and it is not preferable because sufficient hair damage prevention effect, gloss, firmness and moisturizing effect cannot be obtained, If the content of the amino acid or derivative thereof exceeds the above range, it is not preferable because it is uneconomical and may damage hair.

  On the other hand, the addition ratio of propolis to amino acid in the perm solution according to the present invention is not particularly limited, but if the addition ratio is 0.5 to 2,000%, it is very good due to the synergistic effect of propolis and amino acid. It is preferable because the effect of preventing damage to hair and the effect of imparting luster, firmness and moisture can be obtained, and more preferably 20 to 500%.

  In addition, the ratio of the propolis to the amino acid in the hair conditioner according to the present invention is not particularly limited, but if the ratio is 0.5 to 2,000%, the permanent action is caused by the synergistic effect of the propolis and the amino acid. In addition to being good, the effect of preventing damage to the hair and the effect of imparting gloss, firmness and moisture can be obtained, and it is more preferably 100 to 500%.

  Moreover, it is necessary to contain urea in the permanent liquid and hair conditioner according to the present invention. That is, the permanent liquid according to the present invention needs to contain 0.5 to 20% by mass of urea, more preferably 1 to 10% by mass, and more preferably 3 to 7% by mass. Particularly preferred. If the urea content is less than 0.5% by mass, synergism with propolis cannot be obtained, and sufficient hair damage preventing effect, gloss, firmness and moisturizing effect cannot be obtained. If the content exceeds 20% by mass, it is not preferable because it is uneconomical and may promote damage to the hair.

  Furthermore, when fucoidan (a dietary fiber that is a kind of sulfated polysaccharide and is abundant in mucilage of brown algae such as kelp and seaweed) is added to the permanent liquid and hair conditioner according to the present invention, the hair is very efficient. In particular, it is more preferable because it can give gloss, firmness and moisture. The amount of fucoidan added is not particularly limited, but the permanent liquid according to the present invention preferably contains 0.1 to 15% by mass, more preferably 1 to 6% by mass. If the content of fucoidan is less than 0.1% by mass, synergy with propolis cannot be obtained, and sufficient hair damage preventing effect, gloss, firmness and moisturizing effect cannot be obtained. If the content exceeds 15% by mass, it is not preferable because it is uneconomical and the finish of the hair after treatment becomes sticky.

  Furthermore, the permanent liquid and hair conditioner according to the present invention include various alcohols, fermented alcohols, glycols (such as butyl glycol), extracts extracted from plants, preservatives, fragrances, viscosity modifiers as necessary. It is also possible to add a pH adjusting agent or the like. Furthermore, a moisturizing agent (moisture adjusting agent) such as hyaluronic acid (particularly high molecular hyaluronic acid) or the like can be added to the permanent liquid and hair conditioning agent according to the present invention as necessary. In addition, when adding hyaluronic acid to the permanent liquid and hair conditioner according to the present invention, the amount of addition is not particularly limited, but if it is 0.005 to 5% by mass, the moisture retention and economic efficiency of the hair From the viewpoint of, it is more preferable that it is 0.05-2 mass%.

  Furthermore, in the permanent liquid according to the present invention, it is possible to add amines such as isopropanolamine and triethanolamine, if necessary, in order to make the degree of permanent application better. Triethanolamine is more preferable because it can maintain a state of less irritation to the skin. Moreover, it is also possible to use AMPD (2-amino-2-methyl-1,3-propanediol) instead of triethanolamine. The addition amount of amines and AMPD is not particularly limited, but it is preferably 1 to 10% by mass because it causes less irritation to the skin. In addition, various shampoos (so-called protective shampoos and the like) can be added to the permanent liquid according to the present invention.

  Furthermore, the hair conditioner according to the present invention can be added to various hair treatment agents such as perm solution, hair coloring agent, bleaching agent, shampoo, treatment, conditioner and the like. In addition, the addition amount to the hair treatment agent of the hair conditioner according to the present invention is not particularly limited, but the addition amount is preferably 1 to 40% by mass, and more preferably 5 to 20% by mass. If the amount of hair conditioner added to the hair treatment agent is below the above range, it is not preferable because sufficient hair damage preventing effect, gloss, firmness and moisturizing effect cannot be obtained. If the amount added to the hair treatment agent exceeds the above range, it is not preferable because it is uneconomical and the feeling of stickiness of the hair becomes high, making it difficult to clean the hair.

  In addition, the method of applying permanent treatment to the hair using the permanent liquid according to the present invention is not particularly limited, and a digital permanent with heating at around 100 ° C. or a straight permanent using an iron heated at around 180 ° C. In addition, various methods such as air wave, creep perm, aqua perm, water perm (moist perm), and system curl can be used.

  In the production of the permanent liquid and hair conditioner according to the present invention, the production method is not particularly limited, but the raw material or the mixed liquid of the raw materials is heated at a temperature of 30 ° C. to 100 ° C. as necessary. Heating within the range is preferred.

[Examples E and F: Examples of perm solution and hair conditioner]
Hereinafter, the permanent liquid and the hair conditioner according to the present invention will be described in more detail with reference to examples. However, the present invention is not limited to the embodiments of the examples and does not depart from the spirit of the present invention. Thus, it can be changed as appropriate. Moreover, the evaluation methods of physical properties and characteristics in the examples are as follows. In the following sensory evaluations, the average stage (◎, ○, Δ, ×) of the evaluation results for the three subjects was used as the final evaluation result.

<Damage to hair>
Perm was applied to the hair of three subjects by the method described later, and the damaged state of the hair after perm was subjected to sensory evaluation in the following four stages by a beautician.
A: No damage to the hair such as exfoliation of the cuticle, split ends, and cut hairs, and the hair has sufficient luster, firmness and moisture.
○: Hair damage such as cuticle peeling, split ends and cut hair is hardly seen, and the hair has gloss, firmness and moisture.
Δ: Cuticle peeling, split hairs, broken hairs and other hair damages are observed, and the hairs are not glossy, firm or moist.
X: Many damages to the hair such as peeling of the cuticle, split ends, and cut hairs were observed, and there was almost no gloss, firmness or moisture on the hair.

<Decolorization of hair>
Perm was applied to the hair of three test subjects by the method described later, and the decolored state of the hair after perm was subjected to sensory evaluation in the following three stages by a hairdresser.
○: No decolorized part is seen in the hair.
(Triangle | delta): A decoloring part is scattered on hair.
X: Many decoloring parts are seen in the hair.

<Degree of perm>
The condition of the ridges (waves) of the hair after the perm of three subjects was sensorially evaluated by the hairdresser in the following three stages.
A: The degree of perm is very good.
○: Perm is sufficiently applied.
Δ: Perm is weak.
X: Perm is very weak.

<Skin irritation>
The sensory evaluation of the skin irritation felt by the subjects when the permanent hair was applied to the hair of three subjects was evaluated in the following three stages.
○: I hardly feel any irritation.
Δ: Slight irritation is felt.
X: I feel pain.

<Perm liquid smell>
Sensory evaluation of the odor of the perm solution with the permanent applied to the subject was performed in the following three stages.
A: No bad odor is felt.
○: Not particularly bad smell.
Δ: A slight odor is felt.
X: A bad smell is felt.

<State after hair dyeing>
After the hair of three test subjects was dyed with a hair dye by the method described later, the state of the hair after dyeing was subjected to sensory evaluation in the following three stages by a hairdresser.
◯: No cuticle peeling, split hair, broken hair, or other hair damage was observed, and the hair had gloss, firmness and moisture.
Δ: Cuticle peeling, split hairs, broken hairs, and other damage to the hair are observed, and the hair is not glossy, firm, or moist.
X: Many damages to the hair such as peeling of the cuticle, split ends, and cut hairs were observed, and there was almost no gloss, firmness or moisture on the hair.

<Dyed hair spots>
After the hair of three subjects was dyed with a hair dye, the hair dyeing state of the hair after dyeing was subjected to sensory evaluation in the following three stages by a hairdresser.
○: There is no dyed spots, and the dyeing is neatly and uniformly.
Δ: Slightly dyed spots are observed.
X: Many dyed spots are seen.

<Solution uniformity>
The uniformity of the solution of the perm solution and the hair conditioner obtained in the Examples and Comparative Examples was sensory evaluated by the following three stages by visual observation.
A: There is no precipitate at all.
○: Some precipitate is observed.
Δ: Many precipitates are observed.

[Example E-1]
<Preparation of perm solution>
The perm liquid of Example E-1 was obtained by mixing the following components.

<Perm liquid component>
-Aqueous solution of improved cystine (ie, cystine bound to hydrolyzed keratin by platinum) (aqueous solution having a cystine solid content concentration of 2.0%): 3.0% by mass
Amino acid L-arginine: 0.1% by mass
L-lysine (hydrochloride): 0.1% by mass
・ Amizole: 2.0% by mass
-Sodium hyaluronate: 3.0% by mass
・ Glutamic acid-based amino acid: 4.0% by mass
・ Glycerin: 5.0% by mass
・ Dispersant: 6.0% by mass
Propolis solution (20% by mass extract (ethanol solution)): 5.0% by mass (concentration of pure components of propolis = 1.0% by mass)
-Fragrance: 0.2% by mass
-Preservative (ethoxydiglycol, phenoxyethanol, methylparaben, propylparaben, butylparaben, ethylparaben mixed solution): 0.2% by mass
-Academia oil: 3.0% by mass
・ Purified water: remaining amount

  After that, after the prepared perm solution of Example E-1 is attached to the hair, the hairstyle is prepared without applying shampooing, as it is blown with a dryer, and with heat of about 80 ° C. applied by an iron or a heating rod. The hair was given a permanent shape. After that, after washing the hair with a commercially available shampoo and drying the hair by applying heat of about 80 ° C. with a dryer, the condition after the permanent, the degree of perm, the stimulation to the hair according to the above evaluation criteria. The decolorization state of the hair was evaluated. The evaluation results are shown in Table 5 together with the composition of the permanent solution.

[Examples E-2 to E-4]
When preparing the perm solution, the mixing ratio of the improved cystine aqueous solution was changed to 1.0% by mass, 5.0% by mass, and 7.0% by mass, respectively (ie, the pure component of the improved cystine Example E-2 to Example E-1 were carried out in the same manner as in the preparation of the permanent solution of Example E-1, except that the concentrations were changed to 0.02% by mass, 0.1% by mass, and 0.14% by mass, respectively. A perm solution of E-4 was prepared. And after using the permanent solution of those Examples E-2 to E-4 to a test subject by the method similar to Example E-1, it evaluated similarly to Example E-1. The evaluation results are shown in Table 5 together with the composition of the permanent solution.

[Example E-5]
When preparing the perm solution, the same procedure as in Example E-1 was performed except that 0.3% by mass of acetylcysteine was mixed instead of the aqueous solution of improved cystine. A perm solution was prepared. And after using the perm | liquid of the Example E-5 to a test subject by the method similar to Example E-1, it evaluated similarly to Example E-1. The evaluation results are shown in Table 5 together with the composition of the permanent solution.

[Comparative Example E-1]
<Preparation of perm solution>
A liquid having the following composition was prepared as the first agent.
L-cysteine hydrochloride: 4.85% by mass
N-acetyl-L-cysteine: 2.35% by mass
・ Isopropanolamine: 2.50% by mass
・ Sodium carbonate: 2.50 mass%
L-arginine: 0.10% by mass
-Trisodium edetate: 0.10% by mass
・ Polyoxyethylene sorbitan monooleate (20E.O.): 1.20% by mass
-Fragrance: 0.80% by mass
Palm oil fatty acid amidopropyl betaine: 2.02% by mass
・ Purified water: remaining amount

Moreover, the liquid of the following compositions was prepared as a 2nd agent.
・ Sodium bromate: 4.00% by mass
-Sodium monohydrogen phosphate: 0.10% by mass
・ Sodium dihydrogen phosphate: 0.10% by mass
Palm oil fatty acid amidopropyl betaine: 0.50% by mass
・ Sodium benzoate: 0.30% by mass
・ Polyoxyethylene sorbitan monooleate (20E.O.): 0.30% by mass
-Fragrance: 0.20% by mass
-Aminoethylpropylsiloxane-Dimethylsiloxane: 0.10% by mass
..Polyoxyethylene lauryl ether: 0.01% by mass
・ Purified water: remaining amount

  Then, the prepared first agent is attached to the subject's hair in the same manner as in Example 1, and the hair is heated. Then, the prepared second agent is attached to the subject's hair, and then the hair is removed. Washed and dried. And the state after a permanent was evaluated by the evaluation criteria similar to Example E-1. The evaluation results are shown in Table 5 together with the composition of the permanent solution.

<Comparative Example E-2>
Propolis was not mixed when the perm solution was prepared (the mixing ratio of purified water was changed in accordance with the change). And otherwise, a permanent solution of Comparative Example E-2 was obtained in the same manner as Example E-1. Thereafter, using the prepared permanent solution of Comparative Example E-2, the hair was permanently treated in the same manner as in Example E-1, and the hair was washed and dried. And the above-mentioned evaluation criteria evaluated the state after permanent, the degree of perm application, the stimulation to the hair, the decolored state of the hair, and the like. The evaluation results are shown in Table 5 together with the composition of the permanent solution.

<Comparative Example E-3>
When preparing the permanent solution, a permanent solution of Comparative Example E-3 was obtained in the same manner as Example E-1, except that 0.3% by mass of cysteine was mixed instead of the improved cystine. Thereafter, using the prepared permanent liquid of Comparative Example E-3, the hair was permanently treated in the same manner as in Example E-1, and the hair was washed and dried. And the above-mentioned evaluation criteria evaluated the state after permanent, the degree of perm application, the stimulation to the hair, the decolored state of the hair, and the like. The evaluation results are shown in Table 5 together with the composition of the permanent solution.

  From Table 5, the perm liquids according to the present invention (Examples E-1 to E-5) are ordinary perm liquids (Comparative Examples E-1 and E-2) containing no propolis or improved cystine (or acetylcysteine). Compared with), it is understood that the skin is not stimulated during permanent, damage to the hair after permanent is suppressed, and gloss, firmness and moisture can be imparted to the hair. In addition, it can be seen that the perm liquids (Examples E-1 to E-5) according to the present invention have good solution uniformity.

[Example F-1]
<Preparation of hair conditioner>
The following components were mixed at room temperature to obtain hair conditioner A.
-Aqueous solution of improved cystine (ie, cystine bound to hydrolyzed keratin by platinum) (aqueous solution having a cystine solid content concentration of 2.0%): 3.0% by mass
Amino acid L-arginine: 0.1% by mass
L-lysine (hydrochloride): 0.1% by mass
・ Amizole: 1.0% by mass
Propolis solution (20% by mass extract (ethanol solution)): 5.0% by mass (concentration of pure components of propolis = 0.05% by mass)
-Fragrance: 0.2% by mass
-Antiseptic (mixed solution of ethoxydiglycol, phenoxyethanol, methylparaben, propylparaben, butylparaben, ethylparaben): 0.3% by mass
-Academia oil: 3.0% by mass
Amino acid anionic surfactant (25% by mass aqueous solution): 4.0% by mass
・ Dispersant: 6.0% by mass
・ Glycerin: 2.5% by mass
-Sodium hyaluronate: 5.0% by mass
・ Purified water: remaining amount

<Preparation of hair dye>
A liquid having the following composition was prepared as the first hair dye.
・ 28% by mass ammonia water: 3.0% by mass
・ Ethanolamine: 1.5% by mass
-Ammonium bicarbonate: 0.3% by mass
-Paraphenylenediamine: 0.1% by mass
-Paraaminophenol: 0.2% by mass
・ Paraaminoorthocresol: 0.4% by mass
Decylglucoside: 4.0% by mass
・ Laureth-11 Na acetate: 4.0% by mass
・ Laureth-20: 2.0% by mass
・ Myristyl alcohol: 0.2% by mass
Propylene glycol: 4.0% by mass
・ Ethanol: 9.5% by mass
-Fragrance: 0.5% by mass
・ Purified water: remaining amount

Moreover, the liquid of the following compositions was prepared as a 2nd hair dye.
・ 35% by mass hydrogen peroxide solution: 16.3% by mass
・ Cocole glutamate Na: 0.5% by mass
・ Cetanol: 0.5% by mass
-Etidronic acid: 0.1% by mass
48% by weight aqueous sodium hydroxide solution: PH = 3.5 Adjustable amount Purified water: remaining

  Then, in a room temperature room, the 40% by mass of the first hair dye and 60% by mass of the second hair dye obtained as described above were placed in a squeeze foamer container (a nylon container with an internal volume of 150 ml, Yamato Seisakusho). To obtain a mixed hair dye. Thereafter, the modified hair dye of Example F-1 was prepared by adding the aforementioned hair conditioner A so as to have a mixing ratio of 10% by weight with respect to the mixed hair dye.

<Application of hair dye>
Then, the modified hair dye was discharged in the form of foam and adhered to the hair, and 80 g was adhered to the entire hair while repeating the work of foaming again for 2 seconds at the adhered portion. After that, the lathering operation was performed again for 15 seconds, and after standing for a certain time (20 minutes), the hair was rinsed, shampooed and rinsed, and then the hair was dried. And the above-mentioned evaluation criteria evaluated the state after hair dyeing, the hair spot, and the irritation | stimulation to skin. The evaluation results are shown in Table 6.

[Examples F-2 to F-4]
When preparing the hair conditioner, the mixing ratio of the improved cystine aqueous solution was changed to 1.0 mass%, 5.0 mass%, and 7.0 mass%, respectively (that is, the pure cystine Example F was carried out in the same manner as in the preparation of the hair dye of Example F-1, except that the component concentrations were changed to 0.02% by mass, 0.1% by mass, and 0.14% by mass, respectively. -2 to F-4 hair dyes were prepared. And after using the hair dye of those Examples F-2 to F-4 to a test subject by the method similar to Example F-1, it evaluated similarly to Example F-1. The evaluation results are shown in Table 6 together with the composition of the hair conditioner.

[Example F-5]
Example F was prepared in the same manner as in the preparation of the hair dye of Example F-1, except that 0.3% by mass of acetylcysteine was mixed in place of the improved cystine aqueous solution when preparing the hair conditioner. A hair dye of −5 was prepared. Then, the hair dye of Example F-5 was evaluated in the same manner as Example F-1 after being used for the subject in the same manner as in Example F-1. The evaluation results are shown in Table 6 together with the composition of the hair conditioner.

<Comparative Example F-1>
When preparing the hair conditioner, the hair dye of Comparative Example F-1 was prepared in the same manner as the hair dye of Example F-1, except that no propolis was added. And after using the hair dye of the comparative example F-1 to a test subject by the method similar to Example F-1, it evaluated similarly to Example F-1. The evaluation results are shown in Table 6 together with the composition of the hair conditioner.

<Comparative Example F-2>
A hair dye of Comparative Example F-2 was prepared in the same manner as the preparation of the hair dye of Example F-1, except that no improved cystine was added when preparing the hair conditioner. And after using the hair dye of the comparative example F-2 for a test subject by the method similar to Example F-1, it evaluated similarly to Example F-1. The evaluation results are shown in Table 6 together with the composition of the hair conditioner.

<Comparative Example F-3>
Comparative Example F- was prepared in the same manner as in the preparation of the hair dye of Example F-1, except that 0.3% by mass of cysteine was mixed in place of the improved cystine aqueous solution when preparing the hair conditioner. Three hair dyes were prepared. And after using the hair dye of the comparative example F-3 for a test subject by the method similar to Example F-1, it evaluated similarly to Example F-1. The evaluation results are shown in Table 6 together with the composition of the hair conditioner.

  From Table 6, when a hair conditioner containing propolis and improved cystine (or acetylcysteine) was added to the hair dye (Examples F-1 to F-5), propolis or improved cystine (or It can be seen that the hair conditioner containing no acetylcysteine) is added to the hair dye (Comparative Examples F-1 and F-2), and there are few hair spots on the hair and the hair can be uniformly dyed. Moreover, it turns out that the hair conditioner (Examples E-1 to E-5) according to the present invention has good solution uniformity.

  Since the cosmetic according to the present invention exhibits excellent effects as described above, it can be suitably used as various cosmetics such as skin creams, lotions, lotions, and emulsions. Moreover, since the hair restoration agent which concerns on this invention has the outstanding effect as mentioned above, it can be used suitably as a restoration agent for restoring hair with great damage such as split ends. On the other hand, since the skin care lotion according to the present invention has excellent effects as described above, it is effective in removing wrinkles and stains, whitening, preventing sunburn, skin cream for improving symptoms of dermatitis, lotion, and emulsion. It can be suitably used as various skin care lotions. Moreover, since the hair restorer which concerns on this invention has the outstanding effect as mentioned above, it can be used suitably as a hair restorer (hair growth agent, hair nourishing agent) for men or women. On the other hand, since the permanent liquid according to the present invention exhibits excellent effects as described above, it can be suitably used as a permanent liquid that does not damage the hair. Further, since the hair conditioner according to the present invention has excellent effects as described above, it is an auxiliary agent to be added to hair treatment agents such as perm solution, bleaching agent, hair dye, shampoo, treatment, conditioner and the like. Can be suitably used.

Claims (26)

A chemical composition that can be used as a cosmetic, hair repair agent, skin care lotion, hair restorer, perm solution, hair conditioner,
A chemical composition comprising a propolis and an amino acid.   The cosmetic composition according to claim 1, wherein at least a part of the amino acid is cystine bound to hydrolyzed keratin by platinum.   A cosmetic comprising propolis and an amino acid.   4. The amino acid is one obtained by mixing one or two or more of arginine, cysteine, cystine, lysine, threonine, aspartic acid, GABA, or a derivative thereof. Cosmetics.   The cosmetic according to claim 3 or 4, wherein at least a part of cystine is bound to hydrolyzed keratin by platinum.   The cosmetic according to any one of claims 3 to 5, wherein silver ions, zinc ions, titanium ions, or one or more heavy metal ions thereof are mixed.   Hyaluronic acid is contained, Cosmetics in any one of Claims 3-6 characterized by the above-mentioned.   The cosmetic according to any one of claims 3 to 7, comprising fucoidan.   The cosmetic according to any one of claims 3 to 8, wherein the addition ratio of propolis to amino acid is 0.1% or more and less than 100%.   A hair repair agent for repairing damage caused by chemical treatment of hair, comprising a propolis.   The hair repair agent according to claim 10, comprising fucoidan.   The hair repair agent according to claim 10 or 11, comprising an amino acid or a derivative thereof.   The hair repair agent according to any one of claims 10 to 12, comprising hyaluronic acid or a derivative thereof.   The hair repair according to any one of claims 10 to 13, wherein the amino acid is one of cysteine, cystine, lysine, arginine or a derivative thereof, or a mixture of two or more thereof. Agent.   The hair repair agent according to claim 14, wherein at least a part of cystine is bound to hydrolyzed keratin by platinum. It is a lotion such as cream, lotion, milky lotion used for skin care,
A skin care lotion characterized by containing a propolis and an amino acid.   The lotion for skin care according to claim 16, wherein the amino acid is one of cysteine, cystine, arginine, lysine or a derivative thereof, or a mixture of two or more thereof.   The lotion for skin care according to claim 16 or 17, wherein at least a part of cystine is bound to hydrolyzed keratin by platinum.   The lotion for skin care according to any one of claims 16 to 18, comprising hyaluronic acid.   The lotion for skin care according to any one of claims 16 to 19, comprising fucoidan.   The lotion for skin care according to any one of claims 16 to 20, wherein the addition ratio of propolis to amino acid is 5% or more and less than 20%.   A hair restorer containing propolis and amino acids.   The hair restoring agent according to claim 22, wherein at least a part of the amino acid is cystine bound to hydrolyzed keratin by platinum. A permanent solution for changing the shape of the hair by attaching it to the hair,
A permeic solution, characterized in that propolis and cystine or acetylcysteine combined with hydrolyzed keratin by platinum are added.   The perm solution according to claim 24, wherein an amino acid formed by mixing one or more of arginine, cysteine, cystine, lysine, or derivatives thereof is added. A hair conditioner to be added to a hair treatment agent for changing the shape of the hair or decolorizing or coloring the hair,
A hair conditioner characterized by the addition of propolis and cystine or acetylcysteine bound to hydrolyzed keratin by platinum.