CN112386506A - Skin care gel containing peptide-alcohol liposome compound and preparation method thereof - Google Patents
Skin care gel containing peptide-alcohol liposome compound and preparation method thereof Download PDFInfo
- Publication number
- CN112386506A CN112386506A CN201910756007.9A CN201910756007A CN112386506A CN 112386506 A CN112386506 A CN 112386506A CN 201910756007 A CN201910756007 A CN 201910756007A CN 112386506 A CN112386506 A CN 112386506A
- Authority
- CN
- China
- Prior art keywords
- alcohol
- hyaluronic acid
- skin care
- lipid
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000002502 liposome Substances 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title abstract description 13
- 150000001875 compounds Chemical class 0.000 title abstract description 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 63
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 61
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 58
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 58
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 30
- 239000000126 substance Substances 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 15
- 150000002632 lipids Chemical class 0.000 claims abstract description 15
- 239000002904 solvent Substances 0.000 claims abstract description 12
- 239000007853 buffer solution Substances 0.000 claims abstract description 10
- 239000003973 paint Substances 0.000 claims abstract description 4
- 239000000243 solution Substances 0.000 claims description 37
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 28
- 238000003756 stirring Methods 0.000 claims description 28
- 229920001184 polypeptide Polymers 0.000 claims description 19
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 16
- WSGCRSMLXFHGRM-DEVHWETNSA-N (2s)-2-[[(2s)-6-amino-2-[[(2s,3r)-2-[[(2s,3r)-2-[[(2s)-6-amino-2-(hexadecanoylamino)hexanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]hexanoyl]amino]-3-hydroxypropanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(O)=O WSGCRSMLXFHGRM-DEVHWETNSA-N 0.000 claims description 15
- 239000012452 mother liquor Substances 0.000 claims description 15
- 239000006185 dispersion Substances 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 11
- -1 sphingomyelin Chemical compound 0.000 claims description 10
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims description 9
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 229940083466 soybean lecithin Drugs 0.000 claims description 9
- 241000530268 Lycaena heteronea Species 0.000 claims description 8
- 238000009210 therapy by ultrasound Methods 0.000 claims description 8
- 239000008367 deionised water Substances 0.000 claims description 7
- 229910021641 deionized water Inorganic materials 0.000 claims description 7
- 229940075507 glyceryl monostearate Drugs 0.000 claims description 7
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims description 7
- 239000008055 phosphate buffer solution Substances 0.000 claims description 7
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 6
- 238000003760 magnetic stirring Methods 0.000 claims description 6
- 239000011259 mixed solution Substances 0.000 claims description 5
- MVORZMQFXBLMHM-QWRGUYRKSA-N Gly-His-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)CN)CC1=CN=CN1 MVORZMQFXBLMHM-QWRGUYRKSA-N 0.000 claims description 4
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
- JQWAHKMIYCERGA-UHFFFAOYSA-N (2-nonanoyloxy-3-octadeca-9,12-dienoyloxypropoxy)-[2-(trimethylazaniumyl)ethyl]phosphinate Chemical compound CCCCCCCCC(=O)OC(COP([O-])(=O)CC[N+](C)(C)C)COC(=O)CCCCCCCC=CCC=CCCCCC JQWAHKMIYCERGA-UHFFFAOYSA-N 0.000 claims description 3
- LODWEXDBRZBADB-XEVVZDEMSA-N (2s)-6-amino-2-[[(2s)-2-[[(2s)-6-amino-2-(hexadecanoylamino)hexanoyl]amino]-3-methylbutanoyl]amino]hexanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(O)=O LODWEXDBRZBADB-XEVVZDEMSA-N 0.000 claims description 3
- KMACPCJUCHVVGP-FNRPHRCSSA-N (4S)-4-acetamido-5-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-carboxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid Chemical compound OC(=O)CC[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(N)=O KMACPCJUCHVVGP-FNRPHRCSSA-N 0.000 claims description 3
- AJLNZWYOJAWBCR-OOPVGHQCSA-N (4s)-4-acetamido-5-[[(2s)-1-[[(2s)-1-[[(2s)-5-amino-1-[[(2s)-1-[[(2s)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-car Chemical compound OC(=O)CC[C@H](NC(C)=O)C(=C)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O AJLNZWYOJAWBCR-OOPVGHQCSA-N 0.000 claims description 3
- BIABMEZBCHDPBV-MPQUPPDSSA-N 1,2-palmitoyl-sn-glycero-3-phospho-(1'-sn-glycerol) Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCCCC BIABMEZBCHDPBV-MPQUPPDSSA-N 0.000 claims description 3
- KILNVBDSWZSGLL-UHFFFAOYSA-O 2-[2,3-di(hexadecanoyloxy)propoxy-hydroxyphosphoryl]oxyethyl-trimethylazanium Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-UHFFFAOYSA-O 0.000 claims description 3
- BYUQATUKPXLFLZ-UIOOFZCWSA-N CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(O)=O)CC1=CN=CN1 Chemical compound CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(O)=O)CC1=CN=CN1 BYUQATUKPXLFLZ-UIOOFZCWSA-N 0.000 claims description 3
- 101800001147 Octapeptide 1 Proteins 0.000 claims description 3
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 3
- 239000007983 Tris buffer Substances 0.000 claims description 3
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims description 3
- 229940095094 acetyl hexapeptide-8 Drugs 0.000 claims description 3
- 108010006338 acetyl-glutamyl-glutamyl-methionyl-glutaminyl-arginyl-argininamide Proteins 0.000 claims description 3
- 235000012000 cholesterol Nutrition 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 239000007973 glycine-HCl buffer Substances 0.000 claims description 3
- 229940093441 palmitoyl oligopeptide Drugs 0.000 claims description 3
- 229940094912 palmitoyl tripeptide-5 Drugs 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 3
- 229920000053 polysorbate 80 Polymers 0.000 claims description 3
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 3
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 3
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 3
- 239000010413 mother solution Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 11
- 230000035699 permeability Effects 0.000 abstract description 8
- 239000000463 material Substances 0.000 abstract description 4
- 230000005611 electricity Effects 0.000 abstract description 3
- CEVCTNCUIVEQOY-STXHBLNNSA-N fumagillol Chemical compound C([C@@H](O)[C@H](C1[C@]2(C)[C@H](O2)CC=C(C)C)OC)C[C@@]21CO2 CEVCTNCUIVEQOY-STXHBLNNSA-N 0.000 abstract description 3
- 231100000957 no side effect Toxicity 0.000 abstract description 3
- 230000003068 static effect Effects 0.000 abstract description 3
- 210000003491 skin Anatomy 0.000 description 64
- 239000000499 gel Substances 0.000 description 55
- 230000037317 transdermal delivery Effects 0.000 description 9
- 210000004207 dermis Anatomy 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 230000006872 improvement Effects 0.000 description 6
- 210000002950 fibroblast Anatomy 0.000 description 5
- 210000000434 stratum corneum Anatomy 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 239000012466 permeate Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 108010075016 Ceruloplasmin Proteins 0.000 description 2
- 102100023321 Ceruloplasmin Human genes 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 235000019437 butane-1,3-diol Nutrition 0.000 description 2
- 150000003904 phospholipids Chemical class 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 description 1
- 206010001488 Aggression Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 101001054921 Homo sapiens Lymphatic vessel endothelial hyaluronic acid receptor 1 Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102100026849 Lymphatic vessel endothelial hyaluronic acid receptor 1 Human genes 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000016571 aggressive behavior Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000012292 cell migration Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 230000009881 electrostatic interaction Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a skin care gel containing peptide-alcohol liposome compound and a preparation method thereof, comprising the skin care gel containing the peptide-alcohol liposome compound, which is characterized in that: the paint comprises the following components in percentage by weight: 0.1-10% of active peptide, 15-30% of lipid, 1-3% of emulsifier, 50-65% of buffer solution and 10-20% of hyaluronic acid substance; the balance of solvent and water; the invention adopts alcohol liposome as the load material, thus realizing larger load of the skin-care active peptide component; the principle of acting force by static electricity is adopted to realize effective combination of hyaluronic acid gel and alcohol liposome, and the hyaluronic acid gel has good stability, remarkably improves the permeability and the utilization rate of active peptide, and improves the product effect; the components used in the whole formula have good biological compatibility and no side effect.
Description
Technical Field
The invention relates to the field of skin care products, in particular to a skin care gel containing a peptide-alcohol liposome compound and a preparation method thereof.
Background
The peptide is small molecular protein, which is formed by connecting amino acids with a certain sequence through amido bonds, 2 amino acids are called as dycepin, 3 amino acids are called as tripper, and the like; in the skin care process, peptides play important roles, such as cell proliferation, cell migration, pigment formation, protein synthesis and regulation; with the further understanding of the microstructure and the care mechanism of the skin, the application of various peptides in skin care can promote the skin care functions of collagen generation, free radical oxidation resistance, inflammation diminishing and repair and the like.
Research shows that the skin care effect of the active peptide mainly passes through two ways: firstly, the transmission process of neurotransmitter is blocked, and the contraction of muscles is reduced through the signal regulation effect, so that the skin care effect is achieved; secondly, the synthesis of protein in the skin is promoted, so that the skin recovers elasticity and plump and becomes plump.
However, whether the active peptide can play a role or not is critical to the absorption of the skin, and the peptide needs to penetrate through the cell membrane of the stratum corneum and can enter the dermis so as to be absorbed by the skin; since our skin is a natural barrier against external aggressions, the peptide ingredients of cosmetics are blocked on the skin surface, so that the absorption amount of the peptide is limited, and the skin care requirement is difficult to meet.
Therefore, the transdermal delivery preparation based on the nanometer material can significantly improve the permeability and utilization efficiency of the peptide, and is becoming a new focus for the development of skin care products.
Gels are a new form of formulation that is absorbed by skin penetration; when the preparation is used, the active peptide reaches the dermis layer in a pore mode and a mode of penetrating through the stratum corneum and the epidermis layer and plays the effects of protecting and repairing the skin in the dermis layer, and the process is simple, convenient and effective, so the preparation is particularly suitable for skin-care products.
At present, the nano alcohol liposome is a transdermal delivery nano material with excellent performance, and can remarkably entrap active peptides and permeate into a dermis and fibroblasts, so that the permeability and the utilization efficiency of the active peptides are improved.
However, how to effectively utilize alcohol lipid bodies for skin care is a great challenge.
Disclosure of Invention
The invention aims to provide a skin care gel containing peptide-alcohol liposome compound, which improves the permeability and utilization efficiency of peptide in a skin care product; in addition, the invention also provides a preparation method of the skin care gel, and the method can effectively realize the fusion of all substances in the skin care gel and improve the skin care capability of the skin care gel.
In order to achieve the purpose, the invention provides the following technical scheme:
a skin care gel comprising a peptide-alcohol liposome complex, characterized by: the paint comprises the following components in percentage by weight: 0.1-10% of active peptide, 15-30% of lipid, 1-3% of emulsifier, 50-65% of buffer solution and 10-20% of hyaluronic acid substance; the balance of solvent and water.
In a further improvement, the active peptide is one or a mixture of more of ceruloplasmin, acetyl hexapeptide-8, acetyl glutamyl heptapeptide-3, acetyl octapeptide-1, palmitoyl hexapeptide-19, palmitoyl oligopeptide, palmitoyl tripeptide-5 and palmitoyl pentapeptide-3.
In a further improvement, the lipid is one or more of cholesterol, dipalmitoyl lecithin, soybean lecithin, egg yolk lecithin, sphingomyelin, phosphatidylcholine and dipalmitoyl phosphatidylglycerol.
In a further improvement, the emulsifier is one or a mixture of tween 80 and glyceryl monostearate.
In a further improvement, the hyaluronic acid substance is one or a mixture of more of hyaluronic acid, sodium hyaluronate and hyaluronic acid derivatives.
In a further improvement, the buffer solution is one or a mixture of phosphate buffer solution, Tris buffer solution or glycine-HCl buffer solution.
In a further improvement, the solvent is one or a mixture of ethanol, ethylene glycol, propylene glycol, isopropanol, 1, 3-butanediol and glycerol.
The preparation method of the skin care gel comprises the following steps:
firstly, wrapping active polypeptide into alcohol liposome, and the specific method is as follows: 1. adding a proper amount of active polypeptide into a proper amount of water to disperse and dissolve the active polypeptide to obtain an active polypeptide dissolving solution; 2. adding a proper amount of lipid and emulsifier into a solvent, stirring to mutually dissolve the lipid and emulsifier to obtain an alcohol-lipid solution; 3. adding the solution of the polypeptides in the step (1) into the solution of the alcohol lipid in the step (2), and fully stirring to mix the solution of the polypeptides, wherein the stirring speed is 100-600 rpm, and the continuous stirring time is 0.5-3H; 4. carrying out ultrasonic treatment on the mixed solution in the step (3) at the temperature of 20-40 ℃ for 10-30 minutes, and controlling the particle size of the alcohol-lipid to be 50-200 nm through ultrasonic treatment; adjusting the pH value to 7.0-7.5 to obtain the active polypeptide-alcohol lipid dispersion liquid.
Step two, preparing the hyaluronic acid gel, which comprises the following specific steps: and (3) injecting the hyaluronic acid substance into deionized water, and carrying out magnetic stirring for 0.5-1H at a stirring speed of 100-300 rpm to fully and uniformly disperse the hyaluronic acid substance, so as to obtain the hyaluronic acid gel mother liquor.
Step three, preparing the skin care gel, which comprises the following specific steps: and (3) adding the hyaluronic acid gel mother liquor obtained in the second step into the active polypeptide-alcohol-lipid dispersion liquid obtained in the first step, magnetically stirring for 0.5-1H at the stirring speed of 100-300 rpm, and adjusting the viscosity of the hyaluronic acid gel mother liquor to 3000-12000 mpa.s to obtain the skin care gel containing the peptide-alcohol-lipid compound, which can be directly sprayed or smeared.
Compared with the prior art, the invention has the beneficial effects that: the invention adopts alcohol liposome as the load material, thus realizing larger load of the skin-care active peptide component; the principle of acting force by static electricity is adopted to realize effective combination of hyaluronic acid gel and alcohol liposome, and the hyaluronic acid gel has good stability, remarkably improves the permeability and the utilization rate of active peptide, and improves the product effect; the components used in the whole formula have good biological compatibility and no side effect.
Detailed Description
The present invention will be further described with reference to the following examples.
A skin care gel comprising a peptide-alcohol liposome complex, characterized by: the paint comprises the following components in percentage by weight: 0.1-10% of active peptide, 15-30% of lipid, 1-3% of emulsifier, 50-65% of buffer solution and 10-20% of hyaluronic acid substance; the balance of solvent and water.
Further, the active peptide is one or a mixture of more of ceruloplasmin, acetyl hexapeptide-8, acetyl glutamyl heptapeptide-3, acetyl octapeptide-1, palmitoyl hexapeptide-19, palmitoyl oligopeptide, palmitoyl tripeptide-5 and palmitoyl pentapeptide-3.
Further, the lipid is one or more of cholesterol, dipalmitoyl lecithin, soybean lecithin, egg yolk lecithin, sphingomyelin, phosphatidylcholine and dipalmitoyl phosphatidylglycerol.
Further, the emulsifier is one or a mixture of two of tween 80 and glyceryl monostearate.
Further, the hyaluronic acid substance is one or a mixture of more of hyaluronic acid, sodium hyaluronate and hyaluronic acid derivatives.
Further, the buffer solution is one or more of phosphate buffer solution, Tris buffer solution or glycine-HCl buffer solution.
Further, the solvent is one or more of ethanol, ethylene glycol, propylene glycol, isopropanol, 1, 3-butanediol and glycerol.
The preparation method of the skin care gel comprises the following steps:
firstly, wrapping active polypeptide into alcohol liposome, and the specific method is as follows: 1. adding a proper amount of active polypeptide into a proper amount of buffer solution to disperse and dissolve the active polypeptide to obtain an active polypeptide dissolving solution; 2. adding a proper amount of lipid and emulsifier into a solvent, stirring to mutually dissolve the lipid and emulsifier to obtain an alcohol-lipid solution; 3. adding the solution of the polypeptides in the step (1) into the solution of the alcohol lipid in the step (2), and fully stirring to mix the solution of the polypeptides, wherein the stirring speed is 100-600 rpm, and the continuous stirring time is 0.5-3H; 4. carrying out ultrasonic treatment on the mixed solution in the step (3) at the temperature of 20-40 ℃ for 10-30 minutes, and controlling the particle size of the alcohol-lipid to be 50-200 nm through ultrasonic treatment; adjusting the pH value to 7.0-7.5 to obtain the active polypeptide-alcohol lipid dispersion liquid.
Step two, preparing the hyaluronic acid gel, which comprises the following specific steps: and (3) injecting the hyaluronic acid substance into deionized water, and carrying out magnetic stirring for 0.5-1H at a stirring speed of 100-300 rpm to fully and uniformly disperse the hyaluronic acid substance, so as to obtain the hyaluronic acid gel mother liquor.
Step three, preparing the skin care gel, which comprises the following specific steps: and (3) adding the hyaluronic acid gel mother liquor obtained in the second step into the active polypeptide-alcohol-lipid dispersion liquid obtained in the first step, magnetically stirring for 0.5-1H at the stirring speed of 100-300 rpm, and adjusting the viscosity of the hyaluronic acid gel mother liquor to 3000-12000 mpa.s to obtain the skin care gel containing the peptide-alcohol-lipid compound, which can be directly sprayed or smeared.
The following two active polypeptide skin care products are described in detail, and the following embodiments adopt parts by weight and volume of each substance component.
First embodiment, skin care gel containing blue copper peptide-alcohol liposome mixture is prepared
The required raw materials are as follows: (1) active peptide: selecting 10 mg of blue copper peptide; (2) lipid: selecting 120 mg of soybean lecithin; (3) and an emulsifier: selecting 5 mg of glycerin monostearate; (4) and buffer solution: selecting 4 ml of phosphate buffer solution; (5) hyaluronic acid substance: selecting 80 mg of hyaluronic acid; (6) and deionized water: 3 ml of water; (7) and a solvent: 2 ml of ethanol is selected.
The preparation method comprises the following specific steps:
the first step is to prepare the alcohol-lipid dispersion liquid coated with the bluecopper peptides, and the specific method is as follows:
1. adding 120 mg of soybean lecithin and 5 mg of glyceryl monostearate into 2 ml of ethanol, and stirring until the soybean lecithin and the glyceryl monostearate are mutually dissolved to obtain an alcohol-lipid solution; 2. adding 10 mg of blue copper peptide into 4 ml of phosphate buffer solution, and stirring to fully dissolve the blue copper peptide to obtain an active peptide dissolving solution; 3. pouring the active peptide dissolved solution in the step (2) into the alcohol-lipid solution in the step (1), and stirring for 30 minutes to fully mix the active peptide dissolved solution and the alcohol-lipid solution; 4. and (4) carrying out ultrasonic treatment on the mixed solution in the step (3) at the temperature of 20 ℃ for 10 minutes, and adjusting the pH value to 7.0 to obtain the active polypeptide-alcohol lipid dispersion liquid.
In the step, the power of the ultrasound is controlled at 300W; the grain diameter of the alcohol ester is controlled to be 80 nm.
Secondly, preparing hyaluronic acid gel mother liquor, which comprises the following specific steps:
and (3) injecting 80 mg of hyaluronic acid into 3 ml of deionized water solution, and carrying out magnetic stirring for 4H to fully dissolve and age the hyaluronic acid so as to obtain the hyaluronic acid gel mother liquor.
Step three, preparing the skin care gel, which comprises the following specific steps: taking 3 ml of hyaluronic acid gel mother liquor obtained in the second step, and taking 4 ml of active polypeptide-alcohol lipid dispersion liquid obtained in the first step; adding the active polypeptide-alcohol lipid dispersion liquid into the hyaluronic acid gel mother liquid, performing magnetic stirring for 1H, and adjusting the viscosity to 4000mpa.s to obtain the skin-care gel capable of being directly sprayed.
The skin care gel is a skin care gel for transdermal delivery.
The using method comprises the following steps: spraying the prepared skin care gel on the skin, and after 15 minutes, fully absorbing the solution; the gel can quickly permeate into the skin, can deliver more bluecopper peptides into the dermis layer of the skin than the use of the transparent acid gel, and can effectively improve the permeability and the utilization rate of the bluecopper peptides.
Second embodiment, preparation of skin care gel containing palmitoyl pentapeptide-3-ol liposome mixture
The required raw materials are as follows: (1) active peptide: selecting 20 mg of palmitoyl pentapeptide-3; (2) lipid: selecting 100 mg of soybean lecithin; (3) and an emulsifier: selecting 2 mg of glycerin monostearate; (4) and buffer solution: selecting 3 ml of phosphate buffer solution; (5) hyaluronic acid substance: selecting 120 mg of hyaluronic acid; (6) and deionized water: 2 ml of water; (7) and a solvent: ethanol 1.5 ml is selected.
The preparation method comprises the following specific steps:
firstly, preparing an alcohol-lipid dispersion liquid entrapping palmitoyl pentapeptide-3, which comprises the following specific steps:
1. adding 100 mg of soybean lecithin and 2 mg of glyceryl monostearate into 1.5 ml of ethanol, and stirring until the soybean lecithin and the glyceryl monostearate are mutually dissolved to obtain an alcohol-lipid solution; 2. adding 20 mg of palmitoyl pentapeptide-3 into 3 ml of phosphate buffer solution, and stirring to fully dissolve the palmitoyl pentapeptide-3 to obtain a palmitoyl pentapeptide-3 dissolved solution; 3. pouring the palmitoyl pentapeptide-3 dissolved solution in the step (2) into the alcohol-lipid solution in the step (1), and stirring for 30 minutes to fully mix the palmitoyl pentapeptide-3 dissolved solution and the alcohol-lipid solution; 4. and (4) carrying out ultrasonic treatment on the mixed solution in the step (3) at the temperature of 20 ℃ for 15 minutes, and adjusting the pH value to 7.2 to obtain the palmitoyl pentapeptide-3-containing alcohol lipid dispersion liquid.
In the step, the power of the ultrasound is controlled at 300W; the grain diameter of the alcohol ester is controlled to be 100 nm.
Secondly, preparing hyaluronic acid gel mother liquor, which comprises the following specific steps:
and (3) injecting 120 mg of hyaluronic acid into 2 ml of deionized water solution, and carrying out magnetic stirring for 5H to fully dissolve and age the hyaluronic acid so as to obtain the hyaluronic acid gel mother liquor.
Step three, preparing the skin care gel, which comprises the following specific steps: taking 2 ml of hyaluronic acid gel mother liquor obtained in the second step, and taking 3 ml of alcohol-lipid dispersion liquid containing palmitoyl pentapeptide-3 obtained in the first step; adding the alcohol-lipid dispersion containing palmitoyl pentapeptide-3 into the hyaluronic acid gel mother liquor, magnetically stirring for 1H, and adjusting the viscosity to 9000mpa.s to obtain the skin-care gel capable of being directly smeared.
The skin care gel is a skin care gel for transdermal delivery.
The using method comprises the following steps: the prepared skin care gel is smeared on the skin, and after 15 minutes, the solution is fully absorbed; the gel can rapidly permeate into the skin, can deliver more palmitoyl pentapeptide-3 into the dermis layer of the skin than the transparent acid gel, and can effectively improve the permeability and the utilization rate of palmitoyl pentapeptide-3.
The invention adopts alcohol liposome as the load material, thus realizing larger load of the skin-care active peptide component; the principle of acting force by static electricity is adopted to realize effective combination of hyaluronic acid gel and alcohol liposome, and the hyaluronic acid gel has good stability, remarkably improves the permeability and the utilization rate of active peptide, and improves the product effect; the components used in the whole formula have good biological compatibility and no side effect.
In the present invention, the hyaluronic acid gel plays an increasingly important role in transdermal delivery due to its good biocompatibility, physicochemical properties and specific ligand-receptor physiological functions.
Firstly, hyaluronic acid is a glycosaminoglycan, naturally exists in skin extracellular matrix, has good biocompatibility, and has excellent functions of protecting and modifying skin; secondly, the hyaluronic acid has special water absorption performance and hydrophilic-hydrophobic amphoteric structure, not only has good moisturizing performance, but also can reduce the barrier function of stratum corneum through hydration, thereby effectively promoting the skin care activity peptide to penetrate the stratum corneum for transdermal delivery; and finally, the hyaluronic acid gel has entrapping performance in a space grid structure under a certain concentration, can form a composite structure with phospholipid of the nano liposome through electrostatic interaction, realizes the synergistic delivery of the hyaluronic acid gel and the phospholipid, and obviously improves the transdermal delivery performance.
At present, transdermal delivery is researched and proved that a large number of hyaluronic acid receptors are arranged on the surfaces of fibroblasts in the skin, so that hyaluronic acid can be actively gathered on the surfaces of the fibroblasts, targeted gathering of active peptides on the surfaces of the fibroblasts is realized, and the functions of skin care and repair are realized by fully utilizing the effects of the active peptides on the fibroblasts.
In addition, hyaluronic acid and alcohol liposome are combined through electrostatic action to form transdermal delivery skin care gel, so that synergistic permeation of hyaluronic acid and alcohol liposome is realized, the resistance of the active peptide passing through the skin is reduced, the active peptide enters a dermis layer at an accelerated speed, the permeation performance of the skin care active peptide is obviously improved, meanwhile, the alcohol liposome is subjected to targeted aggregation on the surface of a fiber cell and enters a large amount of cells, and the active peptide is promoted to enter the cells to improve the utilization efficiency of the active peptide.
The invention uses ethosome to deliver the active peptide through skin, so that the active peptide is better absorbed by the skin, the wrinkle removing effect of the facial skin can be achieved in a short time, and the skin can be conditioned in the using process to achieve the skin care effect.
The present invention is not limited to the above-described embodiments, and those skilled in the art will be able to make various modifications without creative efforts from the above-described conception, and fall within the scope of the present invention.
Claims (8)
1. A skin care gel comprising a peptide-alcohol liposome complex, characterized by: the paint comprises the following components in percentage by weight: 0.1-10% of active peptide, 15-30% of lipid, 1-3% of emulsifier, 50-65% of buffer solution and 10-20% of hyaluronic acid substance; the balance of solvent and water.
2. The skin care gel containing peptide-alcohol liposome complex as claimed in claim 1, wherein: the active peptide is one or more of blue copper peptide, acetyl hexapeptide-8, acetyl glutamyl heptapeptide-3, acetyl octapeptide-1, palmitoyl hexapeptide-19, palmitoyl oligopeptide, palmitoyl tripeptide-5 and palmitoyl pentapeptide-3.
3. The skin care gel containing peptide-alcohol liposome complex as claimed in claim 1, wherein: the lipid is one or more of cholesterol, dipalmitoyl lecithin, soybean lecithin, egg yolk lecithin, sphingomyelin, phosphatidylcholine, and dipalmitoyl phosphatidylglycerol.
4. The skin care gel containing peptide-alcohol liposome complex as claimed in claim 1, wherein: the emulsifier is one or a mixture of tween 80 and glyceryl monostearate.
5. The skin care gel containing peptide-alcohol liposome complex as claimed in claim 1, wherein: the hyaluronic acid substance is one or a mixture of more of hyaluronic acid, sodium hyaluronate and hyaluronic acid derivatives.
6. The skin care gel containing peptide-alcohol liposome complex as claimed in claim 1, wherein: the buffer solution is one or a mixture of a phosphate buffer solution, a Tris buffer solution or a glycine-HCl buffer solution.
7. The skin care gel containing peptide-alcohol liposome complex as claimed in claim 1, wherein: the solvent is one or more of ethanol, ethylene glycol, propylene glycol, isopropanol, 1.3-butanediol and glycerol.
8. The method of skin care gel containing peptide-alcohol liposome complex according to any one of claims 1-7, comprising the steps of:
firstly, wrapping active polypeptide into alcohol liposome, and the specific method is as follows: 1. adding a proper amount of active polypeptide into a proper amount of water to disperse and dissolve the active polypeptide to obtain an active polypeptide dissolving solution; 2. adding a proper amount of lipid and emulsifier into a solvent, stirring to mutually dissolve the lipid and emulsifier to obtain an alcohol-lipid solution; 3. adding the solution of the polypeptides in the step (1) into the solution of the alcohol lipid in the step (2), and fully stirring to mix the solution of the polypeptides, wherein the stirring speed is 100-600 rpm, and the continuous stirring time is 0.5-3H; 4. carrying out ultrasonic treatment on the mixed solution in the step (3) at the temperature of 20-40 ℃ for 10-30 minutes, and controlling the particle size of the alcohol-lipid to be 50-200 nm through ultrasonic treatment; adjusting the pH value to 7.0-7.5 to obtain active polypeptide-alcohol lipid dispersion liquid;
step two, preparing the hyaluronic acid gel, which comprises the following specific steps: injecting a hyaluronic acid substance into deionized water, and carrying out magnetic stirring for 0.5-1H at a stirring speed of 100-300 rpm to fully and uniformly disperse the hyaluronic acid substance, so as to obtain a hyaluronic acid gel mother solution;
step three, preparing the skin care gel, which comprises the following specific steps: and (3) adding the hyaluronic acid gel mother liquor obtained in the second step into the active polypeptide-alcohol-lipid dispersion liquid obtained in the first step, magnetically stirring for 0.5-1H at the stirring speed of 100-300 rpm, and adjusting the viscosity of the hyaluronic acid gel mother liquor to 3000-12000 mpa.s to obtain the skin care gel containing the peptide-alcohol-lipid compound, which can be directly sprayed or smeared.
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