CN106166256B - External medicine composition, preparation with antiallergic itching-relieving efficacies and preparation method thereof - Google Patents
External medicine composition, preparation with antiallergic itching-relieving efficacies and preparation method thereof Download PDFInfo
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- CN106166256B CN106166256B CN201610640795.1A CN201610640795A CN106166256B CN 106166256 B CN106166256 B CN 106166256B CN 201610640795 A CN201610640795 A CN 201610640795A CN 106166256 B CN106166256 B CN 106166256B
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/05—Chlorophycota or chlorophyta (green algae), e.g. Chlorella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/638—Ligustrum, e.g. Chinese privet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9062—Alpinia, e.g. red ginger or galangal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses a kind of external medicine compositions with antiallergic itching-relieving efficacies.Wherein, which is made of the bulk pharmaceutical chemicals that following weight parts match: raspberry 40~70, the fruit of glossy privet 20~40, haematococcus pluvialis 10~40, galanga galangal seed 30~50, oriental cherry 10~20.The present invention, which is verified by experiments, has very strong inhibiting effect to hyaluronidase, illustrates there is good antiallergic effect.The present invention has good antipruritic effect simultaneously.The present invention, which is prepared into skin care formulation, to be had effects that dispel red blood trace on face well.Raw material of the invention obtain be easy, preparation method it is easy, it is green safe, be easy to be received by allergic human population, have a good application prospect and market prospects.
Description
Technical field
The present invention relates to a kind of external medicine composition, specifically a kind of external application Chinese medicine with antiallergic itching-relieving efficacies
Composition and the Chinese materia medica preparation being prepared by the skin care compositions.
Background technique
The variation of environment influences the clothing, food, lodging and transportion -- basic necessities of life of the mankind and the health of the mankind.There are a variety of in the external environment that we live
Influence the factor of skin health, ultraviolet light, electromagnetic radiation as known to us, haze, acid rain, Enviromental pollutants etc..Harm
Factor can cause the problems of skin, most commonly dry skin, allergy, itch etc..In addition, with age,
Skin also aging therewith, the natural moisturizing factor content in cuticula reduce, and lipid level decline makes vitrification moisture
The problems such as ability decline causes water content in cuticula to reduce, and immunity reduces, and also results in dry skin, allergy and itch.
In order to protect the skin from extraneous infringement, research how effective and safe the protection of carry out skin allergy and effectively mitigate or cure skin
The symptoms such as skin itch are becoming one of the hot spot of health care there research.
Muting sensitive, low stimulation skin care grade are pursued by consumer in existing market.Such product is that selection irritation is weaker
Raw material, but the resistance for how effectively increasing skin is alleviated or is avoided because of skin from skin allergy is solved the problems, such as at all
Pruitus malaise symptoms caused by drying, allergy or other reasons are the emphasis of those skilled in the art's research.
In addition, there is many user's skin of face cuticula weaknesses that capillary position is caused to be easier to contact and perceive
External environment variation, to cause red blood trace on face symptom caused by telangiectasias, such user selects skin care item
It is more prudent.How to help red capillary patient to resist environmental stimuli, mitigate or removal red blood trace on face symptom be also this field urgently
Technical problem to be solved.
Summary of the invention
The primary purpose of the present invention is that proposing a kind of Chinese medicine composition with antiallergic itching-relieving efficacies.
Another object of the present invention is to propose a kind of preparation method of above-mentioned Chinese medicine composition.
Invention thinking of the invention are as follows:
The present invention utilizes advanced biotechnology, in conjunction with the theory of traditional Chinese medical science of Chinese tradition, raspberry, the fruit of glossy privet, rain is raw
Haematococcus, galanga galangal seed and oriental cherry are effectively combined in together, form compound, and as active component, are prepared into skin care system
The effect of agent has and inhibits skin allergy, alleviates pruitus and effectively mitigates skin red capillary.
Raspberry: nature and flavor are sweet, sour, warm-natured.Return liver, kidney, bladder meridian.Have effects that supplementing the kidney to control the nocturnal reducing urination, nourish the liver to improve visual acuity.
The major functions: emission and spermatorrhea, enuresis frequent micturition, impotence and premature ejaculation, mesh are secretly dim-sighted.
The fruit of glossy privet: nature and flavor sweet, bitter, cold.Return liver and kidney channel.Have effects that tonify the liver and kidney, improving eyesight and clearind deficient heat.Cure mainly head
It swoons dizzy, poliosis, blurring of vision and fever due to yin deficiency.
Haematococcus pluvialis: the also known as raw haematococcus in lake or lake green blood ball algae are a kind of generally existing green algas, belong to volvox
Mesh, haematococcus section.Our it is now know that this seeds algae is being suitable for that it is widely present in nature under conditions of growth.
Galanga galangal seed: nature and flavor are acrid in flavour and warm in nature.Returns spleen, lung channel.Have effects that cold dispelling eliminating dampness and refresh minds and help digestion.It is mainly used for stomach duct and abdomen
Crymodynia, dyspepsia turgor, vomiting and diarrhea and drinking too much.
Oriental cherry: having effects that good pore refining and Sage Extract, natural vitamin A rich in, B, E, cherry
The drug effect that leaf flavones also has beautifying face and moistering lotion, promotes sugar metabolism.Flowering Cherry Cultivars are quite various, and number is more than 300 kinds or more,
The whole world shares about 150 kinds of wild oriental cherry, and China has more than 50 kinds.The present invention is to Flowering Cherry Cultivars without limitation.
To achieve the purpose of the present invention, the present invention uses following specific technical solution:
A kind of external medicine composition with antiallergic itching-relieving efficacies, wherein the Chinese medicine composition is by following weight parts
The bulk pharmaceutical chemicals of proportion are made:
Raspberry 40~70, the fruit of glossy privet 20~40, haematococcus pluvialis 10~40, galanga galangal seed 30~50, oriental cherry 10~20.
The preferable weight of above-mentioned each bulk pharmaceutical chemicals of external medicine composition are as follows:
Raspberry 50~70, the fruit of glossy privet 30~40, haematococcus pluvialis 25~40, galanga galangal seed 40~50, oriental cherry 15~20.
A kind of preparation method of above-mentioned external medicine composition, wherein the method comprises the following steps:
(1) bulk pharmaceutical chemicals are weighed according to above-mentioned weight and is crushed to 60~80 mesh and be uniformly mixed；
It (2) is the extraction of 60%~95% ethyl alcohol with percent by volume, bulk pharmaceutical chemicals and ethyl alcohol mass volume ratio g/mL are 1:10
~1:20,50 DEG C~70 DEG C are extracted 1~2 hour to obtain extracting solution；
(3) extracting solution that step (2) obtains is cooled to room temperature, the filtering of 80~120 mesh obtains filtrate；
(4) filtrate rotary evaporation ethyl alcohol is concentrated into crude drug concentration is 0.2~0.5g/mL, obtains concentrate；Crude drug concentration is
Crude drug gross mass is divided by obtained by concentrate volume；
(5) 1,3-BDO that original amount of alcohol is added in concentrate is miscible uniformly, and vacuum filtration collects filtrate to obtain the final product.
The preferred volume percentage of ethyl alcohol is 70% in the step (2), bulk pharmaceutical chemicals and ethyl alcohol better quality volume ratio g/
Ml is 1:15.
Vacuum filtration condition is that 0.8~1.5 μm of filter plate is spread in Buchner funnel in the step (5), is filtered by vacuum.
A kind of external application Chinese medicine extract with antiallergic itching-relieving efficacies, wherein the extract is extracted by the above method
It obtains.
Purposes of the above-mentioned Chinese medical extract in the external-use skin care preparation that preparation has antiallergic itching-relieving efficacies.
A kind of skin care formulation with antiallergic itching-relieving efficacies, wherein the skin care formulation is by above-mentioned Chinese medical extract and shield
Skin product field customary adjuvant is made.
A kind of external skin-care composition with antiallergic itching-relieving efficacies, wherein the skin care compositions is by A phase, B phase and C
Phase composition；The A phase, B phase and C phase are composed of the following weight percentages of raw materials respectively:
A kind of preparation method of above-mentioned skin care compositions, wherein described method includes following steps:
(1) xanthan gum in B phase and glycerol are added into water after mixing, it is spare；Allantoin, EDETATE SODIUM, niacinamide are added
Enter in above-mentioned xanthan gum glycerol mixture, heating stirring is to 80~95 DEG C, insulated and stirred 10~40 minutes；
(2) A phase raw material is successively weighed, mixing is warming up to 80~95 DEG C, insulated and stirred 10~40 minutes；
(3) the A phase raw material that step (2) obtains is added in step (1) B phase, is stirred homogeneous 5~15 minutes；
(4) 40 DEG C or less each raw materials of addition C phase are cooled to, are stirred evenly, discharging.
What the above method was prepared is spray, utilizes Chinese medicine composition of the present invention and skin care field routine side
Other dosage forms, such as cream, toner or lotion can also be prepared in method and auxiliary material.Chinese medicine composition of the present invention uses
Alcohol extracting method extracts, and alcohol extracting method is the optimum extracting method that inventor recommends.But it can also be used known in other Chinese pharmacology fields
Extracting method extract, such as water mentions, or even smearing skin can also play described effect after being simply pulverized and mixed, only function
It imitates slightly weak compared with alcohol extracting.
Preparation of the present invention is recommended to use method are as follows: imposes on human skin surface with spray method, gently massage is straight
To absorption.
Beneficial outcomes of the invention:
The present invention, which is verified by experiments, has very strong inhibiting effect to hyaluronidase, illustrates there is good antiallergic function
Effect.The present invention has good antipruritic effect simultaneously.The present invention is prepared into skin care formulation and dispels red blood trace on face with good
The effect of.Easy, preparation method simplicity that raw material of the present invention obtain, it is green safe, it is easy to be received by allergic human population, has fine
Application prospect and market prospects.
Detailed description of the invention
Fig. 1 is the measurement result figure of Chinese medical extract hyaluronic acid enzyme inhibition rate of the present invention；
Fig. 2 is that human body face VISIA image represents figure.
Specific embodiment
Medicinal material used in the present embodiment can be commercially available from China Medicament Group Corp., meet People's Republic of China's medicine
2010 editions standards of allusion quotation.Other raw materials can be obtained by commercially available purchase, and the present invention is shown in Table 1 using the source of raw material, institute of the present invention
Instrument title and producer are shown in Table 2.
Table 1
Table 2
The preparation of the Chinese medicine composition of the present invention of embodiment 1
(1) bulk pharmaceutical chemicals are weighed according to following proportions, is crushed to 60 mesh, mixed；
Raspberry 65g, fruit of glossy privet 35g, haematococcus pluvialis 40g, galanga galangal seed 50g, oriental cherry 20g.
It (2) is the extraction of 95% ethyl alcohol with percent by volume, bulk pharmaceutical chemicals and ethyl alcohol mass volume ratio g/mL are 1:15, and 70 DEG C add
Extracting solution is extracted 1 hour to obtain in thermal agitation；
(3) extracting solution that step (2) obtains is cooled to room temperature, the filtering of 120 mesh obtains filtrate；
(4) filtrate rotary evaporation ethyl alcohol is concentrated into crude drug concentration is 0.5g/mL, obtains concentrate；
(5) 1,3-BDO that original amount of alcohol is added in concentrate is miscible uniformly, and 1.2 μm of filter plates are spread in Buchner funnel
Vacuum filtration collects filtrate to obtain the final product.
The preparation of the Chinese medicine composition of the present invention of embodiment 2
(1) bulk pharmaceutical chemicals are weighed according to following proportions, is crushed to 70 mesh, mixed；
Raspberry 40g, fruit of glossy privet 20g, haematococcus pluvialis 30g, galanga galangal seed 45g, oriental cherry 15g.
It (2) is the extraction of 70% ethyl alcohol with percent by volume, bulk pharmaceutical chemicals and ethyl alcohol mass volume ratio g/mL are 1:10, and 60 DEG C add
Extracting solution is extracted 1.5 hours to obtain in thermal agitation；
(3) extracting solution that step (2) obtains is cooled to room temperature, the filtering of 100 mesh obtains filtrate；
(4) filtrate rotary evaporation ethyl alcohol is concentrated into crude drug concentration is 0.3g/mL, obtains concentrate；
(5) 1,3-BDO that original amount of alcohol is added in concentrate is miscible uniformly, and 1.5 μm of filter plates are spread in Buchner funnel
Vacuum filtration collects filtrate to obtain the final product.
The preparation of the Chinese medicine composition of the present invention of embodiment 3
(1) bulk pharmaceutical chemicals are weighed according to following proportions, is crushed to 80 mesh, mixed；
Raspberry 70g, fruit of glossy privet 40g, haematococcus pluvialis 10g, galanga galangal seed 30g, oriental cherry 10g.
It (2) is the extraction of 60% ethyl alcohol with percent by volume, bulk pharmaceutical chemicals and ethyl alcohol mass volume ratio g/mL are 1:20, and 50 DEG C add
Extracting solution is extracted 2 hours to obtain in thermal agitation；
(3) extracting solution that step (2) obtains is cooled to room temperature, the filtering of 80 mesh obtains filtrate；
(4) filtrate rotary evaporation ethyl alcohol is concentrated into crude drug concentration is 0.2g/mL, obtains concentrate；
(5) 1,3-BDO that original amount of alcohol is added in concentrate is miscible uniformly, and 0.8 μm of filter plate is spread in Buchner funnel
Vacuum filtration collects filtrate to obtain the final product.
The preparation of the spray of the present invention of embodiment 4
Component and dosage are shown in Table 3:
Table 3
Preparation method
(1) xanthan gum in B phase and glycerol are added into water after mixing, it is spare；Allantoin, EDETATE SODIUM, niacinamide are added
Enter in above-mentioned xanthan gum glycerol mixture, heating stirring is to 80 DEG C, 1 DEG C/mim of heating rate, insulated and stirred 20 minutes；
(2) A phase raw material is successively weighed, mixing is warming up to 80 DEG C, 1 DEG C/mim of heating rate, insulated and stirred 20 minutes；
(3) the A phase raw material that step (2) obtains is added in step (1) B phase, is stirred homogeneous 10 minutes；
(4) 40 DEG C of each raw materials of addition C phase are cooled to, 1 DEG C/mim of rate of temperature fall mixes uniformly discharging.
The preparation of the spray of the present invention of embodiment 5
Component and dosage are shown in Table 4:
Table 4
Preparation method
(1) xanthan gum in B phase and glycerol are added into water after mixing, it is spare；Allantoin, EDETATE SODIUM, niacinamide are added
Enter in above-mentioned xanthan gum glycerol mixture, heating stirring is to 90 DEG C, 2 DEG C/mim of heating rate, insulated and stirred 10 minutes；
(2) A phase raw material is successively weighed, mixing is warming up to 90 DEG C, 2 DEG C/mim of heating rate, insulated and stirred 10 minutes；
(3) the A phase raw material that step (2) obtains is added in step (1) B phase, is stirred homogeneous 15 minutes；
(4) 30 DEG C of each raw materials of addition C phase are cooled to, 2 DEG C/mim of rate of temperature fall is stirred evenly, discharging.
The preparation of the spray of the present invention of embodiment 6
Component and dosage are shown in Table 5:
Table 5
Preparation method
(1) xanthan gum in B phase and glycerol are added into water after mixing, it is spare；Allantoin, EDETATE SODIUM, niacinamide are added
Enter in above-mentioned xanthan gum glycerol mixture, heating stirring is to 95 DEG C, 1 DEG C/mim of heating rate, insulated and stirred 40 minutes；
(2) A phase raw material is successively weighed, mixing is warming up to 95 DEG C, 2 DEG C/mim of heating rate, insulated and stirred 40 minutes；
(3) the A phase raw material that step (2) obtains is added in step (1) B phase, is stirred homogeneous 5 minutes；
(4) 35 DEG C of each raw materials of addition C phase are cooled to, 2 DEG C/mim of rate of temperature fall is stirred evenly, discharging.
Efficacy experiments of the present invention
One, antianaphylaxis effect
1, experimental principle
This method inhibits antiallergy effect of method measurement cosmetic material and cosmetic product using hyaluronidase in vitro.
Hyaluronidase is anaphylactoid participant, decomposes intracorporal hyaluronic acid (HA), it is made to become the acid thorn of low molecular weight
Stimulus causes histamine release, and induction body generates condition susceptible, research shows that hyaluronidase and inflammation, allergy have strong correlation
Property, many Claritins play the role of high inhibition hyaluronidase activity.Hyaluronidase can hydrolyze indiscriminately
The Isosorbide-5-Nitrae key between β-N-acetyl-glucosamine and D- glucuronate in bright matter acid, and β-N-acetyl-glucosamine is obtained, β-N- second
Acyl aminoglucose can be condensed the former 2- methyl -3- diacetyl azole derivatives that add lustre to acetylacetone,2,4-pentanedione under alkaline condition, raw
Chromogen is added lustre in concentrated hydrochloric acid ethyl alcohol with p- dimethylaminobenzaldehyde.
2, experiment content
It is carried out using hyaluronidase body outer suppressioning experiment Elson-Morgan method.Take 0.1mL 0.25mmol/L CaCl2
37 DEG C of heat insulating culture 20min of solution and 0.5mL hyaluronic acid enzyme solution；Embodiment 1 is added and prepares Chinese medical extract 0.5mL, continues
37 DEG C of heat insulating culture 20min；0.5mL Sodium Hyaluronate liquid 37 DEG C of heat preservations 30min, room temperature 5min are added；It is added
0.1mL0.4mol/L NaOH solution and 0.5mL acetylacetone,2,4-pentanedione solution, be placed in boiling water bath heat 15min after immediately with ice water into
The cooling 5min of row；Be added Ehrlich's reagent 1.0mL simultaneously be diluted with 3.0mL dehydrated alcohol, place 20min colour developing, with point
Its absorbance value of light photometric determination.Antiallergic activity calculation formula:
In formula: A --- contrast solution ABS value (replaces sample solution with hac buffer)
B --- control blank solution ABS value (replacing sample solution and enzyme solution with hac buffer)
C --- sample solution ABS value
D --- sample blank solution A BS value (replacing enzyme solution with hac buffer)
The length scanning of 450~700nm range is first carried out when experiment to A group sample, to determine maximum absorption wavelength, then
Using deionized water as reference, ABS value measurement is carried out respectively at the maximum absorption wavelength.
The difference of the measured value twice of same sample should be no more than measures the 10% of average value twice.
3, interpretation of result
The measurement result of the hyaluronic acid enzyme inhibition rate of used sample is tested as shown in Figure 1, test concentrations are 1.0%
Aqueous solution, data are average value three times.
Analysis: wherein positive control is dipotassium glycyrrhizinate.Inhibiting rate is found out in effective range by Fig. 1, prepared by embodiment 1
The inhibiting rate of Chinese medical extract (0~100%) in effective range has effects that inhibit hyaluronidase, and bigger effect
Fruit is better (effective range 0~100%).Embodiment 1 prepares extract hyaluronic acid enzyme inhibition rate close to positive control.
Therefore, embodiment 1 prepares Chinese medical extract with antiallergic effect.It is prepared by inventor's embodiment 2, embodiment 3
Chinese medical extract carries out identical experiment, leads to the same conclusion.It is good to illustrate that Chinese medical extract prepared by the present invention has
Antiallergic effect.
Two, itching-relieving efficacies are studied --- and histamine phosphate causes method of itching
1, experimental material
Experimental animal: cavy 32, half male and half female, 350 ± 20g.
Given the test agent: embodiment 1 prepares Chinese medical extract dosage: high dose group 1.0g/Kg；Middle dose group is 0.6g/
Kg；Low dose group is 0.2g/Kg.Model control group: distilled water (1.0g/Kg).
2, experimental method
A. cavy 32 are taken, the instep shaving after testing preceding 1 day right side is randomly divided into 4 groups.I.e. embodiment 1 prepares Chinese medicine and mentions
Take object high dose group, middle dose group, low dose group and model control group.
B. corresponding dosage sample, model control group are uniformly smeared respectively at shaving within continuous 2 days.
C. it tests the 3rd day, precision weighs that histamine phosphate is appropriate, and being made into percent by volume before use with distilled water is
0.01%, 0.02%, 0.03%, 0.04% ... gradient concentration is spare.It will be abraded at instep shaving behind the cavy right side with coarse sandpaper,
Area about 1cm2, part coating 1 time again, after last coating 10min abrasion drip 0.01% histamine phosphate 0.05mL, after
It is every time 0.05mL every 3 minutes according to 0.01%, 0.02%, 0.03%, 0.04% ... progressive concentration.Until there is globefish
Mouse later licks right metapedes, causes to itch finally to occur dripping the histamine phosphate total amount average value taken when cavy turns one's head and licks right metapedes
Threshold.
D. the otherness between each group itch-threshold and comparative group is calculated.
6 cavy histamine phosphate of table causes the influence (x ± s, n=6) of reaction of itching
Note: compared with model control group, p < 0.05 *
As seen from the above table, compared with model group, sample sets have to cavy histamine phosphate cause reaction of itching and significant inhibit to make
With (P < 0.05).Therefore, embodiment 1 prepares Chinese medical extract with good antipruritic effect.Inventor's embodiment 2 is implemented
Spray prepared by Chinese medical extract and embodiment 4 to 6 prepared by example 3 carries out identical experiment, leads to the same conclusion.Explanation
Chinese medical extract prepared by the present invention and spray have good itching-relieving efficacies.
Three, spray prepared by the present invention dispels the experiment of red capillary efficacy assessments
Red blood trace on face, medically also known as facial telangiectasias are the elasticity drops due to facial capillary wall
Low, brittleness enhancing, continuous vessel, non-uniform expansion even rupture cause.
1. experimental method
(1) experimental principle: influence using human body face VISIA image analysis sample to subject's red blood trace on face is sentenced
Disconnected sample goes red capillary effect.
(2) laboratory sample: embodiment 4 prepares spray
(3) Subject Population and testing time: selection has red capillary symptom 30, and recipient site has obvious red capillary disease
Shape, tested period do not smear any drug or cosmetics unrelated with experiment.
(4) mode is smeared: full face sprinkling, once in the morning and once at night.Facial VISIA before and after observation comparison subject's surrounding
Image.
2. experimental result
Before preparing spray surrounding using embodiment 4 to subject by the professional person with skin clinical evaluation experience
Rear face red capillary dispels the observation and analysis of situation, obtains that the results are shown in Table 7.
Judgment criteria:
Obvious removal (effective): treatment face have 70% without red capillary, without sufferings, elasticity well, skin color it is normal,
Partial skin appearance and normal skin are slightly different.
Removal (effective): treatment face have 50% without red capillary, without sufferings, elasticity well, skin color it is normal, part
Skin appearance is slightly different with normal skin.
Invalid: treatment face has 80% or more still to have obvious red capillary symptom, and shade is different or skin shades, and has
Scratchiness.
Table 7
As can be seen from Table 7, for red blood trace on face symptom, effective percentage reaches 70%, wherein obviously removal 9, occupies
The 43% of efficiency.Fig. 2 is that human body face VISIA image represents figure, as shown in Fig. 2, subject is spraying using the preparation of embodiment 4
(right figure) red blood trace on face (box selected areas) is obvious thin out (left figure is before smearing) after agent four weeks, and the colour of skin becomes uniform.It says
Bright embodiment 4, which prepares spray, has improvement skin microcirculation, goes the effect of red capillary.
Inventor prepares extract with embodiment 1,2,3 and embodiment 5,6 prepares spray and equally does above-mentioned test, as a result
With embodiment 4.Illustrate that the present composition has effects that good removal red blood trace on face, improves skin microcirculation.
Claims (10)
1. a kind of external medicine composition with antiallergic itching-relieving efficacies, which is characterized in that the external medicine composition is under
The bulk pharmaceutical chemicals for stating weight are made:
Raspberry 40~70, the fruit of glossy privet 20~40, haematococcus pluvialis 10~40, galanga galangal seed 30~50, oriental cherry 10~20.
2. external medicine composition as described in claim 1, which is characterized in that the external medicine composition is by following weight
The bulk pharmaceutical chemicals of part proportion are made:
Raspberry 50~70, the fruit of glossy privet 30~40, haematococcus pluvialis 25~40, galanga galangal seed 40~50, oriental cherry 15~20.
3. a kind of preparation method of external medicine composition as claimed in claim 1 or 2, which is characterized in that the preparation method step
It is rapid as follows:
(1) bulk pharmaceutical chemicals are weighed according to weight as claimed in claim 1 or 2, is crushed to 60~80 mesh and is uniformly mixed；
(2) it is the extraction of 60%~95% ethyl alcohol with percent by volume, bulk pharmaceutical chemicals and ethyl alcohol mass volume ratio g/mL are 1:10~1:
20,50 DEG C~70 DEG C are extracted 1~2 hour to obtain extracting solution；
(3) extracting solution that step (2) obtains is cooled to room temperature, the filtering of 80~120 mesh obtains filtrate；
(4) filtrate rotary evaporation ethyl alcohol is concentrated into crude drug concentration is 0.2~0.5g/mL, obtains concentrate；
(5) 1,3-BDO that original amount of alcohol is added in concentrate is miscible uniformly, and vacuum filtration collects filtrate to obtain the final product.
4. preparation method as claimed in claim 3, which is characterized in that the percent by volume of ethyl alcohol is in the step (2)
70%, bulk pharmaceutical chemicals and ethyl alcohol mass volume ratio g/ml are 1:15.
5. preparation method as claimed in claim 3, which is characterized in that vacuum filtration condition is in Bu Shi in the step (5)
0.8~1.5 μm of filter plate is spread in funnel, is filtered by vacuum.
6. a kind of external application Chinese medicine extract with antiallergic itching-relieving efficacies, which is characterized in that the external application Chinese medicine extract is by weighing
Benefit require any one of 3 to 5 described in preparation method extract to obtain.
7. use of the external application Chinese medicine extract described in claim 6 in the external-use skin care preparation that preparation has antiallergic itching-relieving efficacies
On the way.
8. a kind of skin care formulation with antiallergic itching-relieving efficacies, which is characterized in that the skin care formulation as described in claim 6 in
Medicament extract and skin care field customary adjuvant are made.
9. a kind of external skin-care composition with antiallergic itching-relieving efficacies, which is characterized in that the external skin-care composition is by A
Phase, B phase and C phase composition；The A phase, B phase and C phase are composed of the following weight percentages of raw materials respectively:
10. a kind of preparation method of external skin-care composition described in claim 9, which is characterized in that the preparation method includes
Following steps:
(1) xanthan gum in B phase and glycerol are added into water after mixing, it is spare；Allantoin, EDETATE SODIUM, niacinamide are added
It states in xanthan gum glycerol mixture, heating stirring is to 80~95 DEG C, insulated and stirred 10~40 minutes；
(2) A phase raw material is successively weighed, mixing is warming up to 80~95 DEG C, insulated and stirred 10~40 minutes；
(3) the A phase raw material that step (2) obtains is added in step (1) B phase, is stirred homogeneous 5~15 minutes；
(4) 40 DEG C or less each raw materials of addition C phase are cooled to, are stirred evenly, discharging.
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| CN104666873A (en) * | 2015-02-17 | 2015-06-03 | 北京工商大学 | Externally applied traditional Chinese medicinal composition with anti-sensitivity, itching relieving and anti-inflammatory effects, preparation and preparation method of externally applied traditional Chinese medicinal composition |
| CN104784312A (en) * | 2015-04-21 | 2015-07-22 | 北京东方淼森生物科技有限公司 | Externally applied traditional Chinese medicine combination with stimulus restraining efficacy and preparation method thereof |
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| CN104666873A (en) * | 2015-02-17 | 2015-06-03 | 北京工商大学 | Externally applied traditional Chinese medicinal composition with anti-sensitivity, itching relieving and anti-inflammatory effects, preparation and preparation method of externally applied traditional Chinese medicinal composition |
| CN104784312A (en) * | 2015-04-21 | 2015-07-22 | 北京东方淼森生物科技有限公司 | Externally applied traditional Chinese medicine combination with stimulus restraining efficacy and preparation method thereof |
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